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ChEBI ID: 145515
| Member | Definition | Class |
|---|---|---|
| bicuculline | A benzylisoquinoline alkaloid that is 6-methyl-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinoline which is substituted at the 5-pro-S position by a (6R)-8-oxo-6,8-dihydrofuro[3,4-e][1,3]benzodioxol-6-yl group. A light-sensitive competitive antagonist of GABAA receptors. It was originally identified in 1932 in plant alkaloid extracts and has been isolated from Dicentra cucullaria, Adlumia fungosa, Fumariaceae, and several Corydalis species. | bicuculline |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 1,588 (26.29) | 18.7374 |
| 1990's | 1,847 (30.57) | 18.2507 |
| 2000's | 1,705 (28.22) | 29.6817 |
| 2010's | 816 (13.51) | 24.3611 |
| 2020's | 85 (1.41) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 3 (0.05%) | 5.53% |
| Reviews | 65 (1.04%) | 6.00% |
| Case Studies | 1 (0.02%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 6,184 (98.90%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| chromobox protein homolog 1 | Homo sapiens (human) | Potency | 79.4328 | 1 | 1 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 25.1189 | 1 | 1 |
| geminin | Homo sapiens (human) | Potency | 2.3109 | 1 | 1 |
| importin subunit beta-1 isoform 1 | Homo sapiens (human) | Potency | 70.7946 | 1 | 1 |
| snurportin-1 | Homo sapiens (human) | Potency | 70.7946 | 1 | 1 |
| thioredoxin reductase | Rattus norvegicus (Norway rat) | Potency | 70.7946 | 1 | 1 |