Page last updated: 2024-08-05 15:41:58

uncoupling protein inhibitor

Any inhibitor that acts on uncoupling protein.

ChEBI ID: 145437

Members (3)

MemberDefinitionClass
genipinGenipin
guanosine diphosphateA purine ribonucleoside 5'-diphosphate resulting from the formal condensation of the hydroxy group at the 5' position of guanosine with pyrophosphoric acid.GDP
guanosine triphosphateGTP

Research

Studies (17,416)

TimeframeStudies, Drugs with This Role(%)All Drugs %
pre-19905,677 (32.60)18.7374
1990's4,831 (27.74)18.2507
2000's3,529 (20.26)29.6817
2010's2,618 (15.03)24.3611
2020's761 (4.37)2.80

Study Types

Publication TypeStudies, Drugs with this Role (%)All Drugs (%)
Trials30 (0.15%)5.53%
Reviews952 (4.74%)6.00%
Case Studies36 (0.18%)4.05%
Observational1 (0.00%)0.25%
Other19,056 (94.92%)84.16%

Protein Targets (53)

Potency Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
67.9K proteinVaccinia virusPotency28.183811
aldehyde dehydrogenase 1 family, member A1Homo sapiens (human)Potency2.818411
arylsulfatase AHomo sapiens (human)Potency21.331311
Fumarate hydrataseHomo sapiens (human)Potency15.848911
phosphopantetheinyl transferaseBacillus subtilisPotency14.125411
polyproteinZika virusPotency15.848911
regulator of G-protein signaling 4Homo sapiens (human)Potency0.597311
survival motor neuron protein isoform dHomo sapiens (human)Potency14.125411
TDP1 proteinHomo sapiens (human)Potency5.311322
thioredoxin reductaseRattus norvegicus (Norway rat)Potency29.934922

Inhibition Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase 9Homo sapiens (human)IC5076.500012
4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase 9Homo sapiens (human)Ki79.300012
4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT5Homo sapiens (human)IC5067.000011
4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT6Homo sapiens (human)IC50125.260015
72 kDa type IV collagenaseHomo sapiens (human)IC50125.260015
Alpha-(1,3)-fucosyltransferase 7Homo sapiens (human)IC50125.260015
CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1Homo sapiens (human)IC50125.260015
Disintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)IC50200.000011
GABA theta subunitRattus norvegicus (Norway rat)IC5067.000011
Gamma-aminobutyric acid receptor subunit alpha-1Rattus norvegicus (Norway rat)IC5067.000011
Gamma-aminobutyric acid receptor subunit alpha-2Rattus norvegicus (Norway rat)IC5067.000011
Gamma-aminobutyric acid receptor subunit alpha-3Rattus norvegicus (Norway rat)IC5067.000011
Gamma-aminobutyric acid receptor subunit alpha-4Rattus norvegicus (Norway rat)IC5067.000011
Gamma-aminobutyric acid receptor subunit alpha-5Rattus norvegicus (Norway rat)IC5067.000011
Gamma-aminobutyric acid receptor subunit alpha-6Rattus norvegicus (Norway rat)IC5067.000011
Gamma-aminobutyric acid receptor subunit beta-1Rattus norvegicus (Norway rat)IC5067.000011
Gamma-aminobutyric acid receptor subunit beta-2Rattus norvegicus (Norway rat)IC5067.000011
Gamma-aminobutyric acid receptor subunit beta-3Rattus norvegicus (Norway rat)IC5067.000011
Gamma-aminobutyric acid receptor subunit deltaRattus norvegicus (Norway rat)IC5067.000011
Gamma-aminobutyric acid receptor subunit epsilonRattus norvegicus (Norway rat)IC5067.000011
Gamma-aminobutyric acid receptor subunit gamma-1Rattus norvegicus (Norway rat)IC5067.000011
Gamma-aminobutyric acid receptor subunit gamma-2Rattus norvegicus (Norway rat)IC5067.000011
Gamma-aminobutyric acid receptor subunit gamma-3Rattus norvegicus (Norway rat)IC5067.000011
Gamma-aminobutyric acid receptor subunit piRattus norvegicus (Norway rat)IC5067.000011
MatrilysinHomo sapiens (human)IC50125.260015
Tyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)IC50500.000011
Tyrosine-protein phosphatase non-receptor type 11Homo sapiens (human)IC50500.000011
Tyrosine-protein phosphatase non-receptor type 2Homo sapiens (human)IC50500.000011

Activation Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
2-dehydropantoate 2-reductaseEscherichia coli K-12Kd263.000012
Chain A, ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 3Mus musculus (house mouse)Kd0.024011
Chain A, Elongation factor 2Saccharomyces cerevisiae (brewer's yeast)Kd3.900011
Chain A, Elongation Factor GThermus thermophilus HB8Kd11.000011
Chain A, ELONGATION FACTOR TU (EF-TU)Bos taurus (cattle)Kd1.000011
Chain A, Eukaryotic peptide chain release factor GTP-binding subunitSchizosaccharomyces pombe (fission yeast)Kd3.800011
Chain A, Guanine nucleotide-binding protein G(i), alpha-1 subunitHomo sapiens (human)Kd1.200011
Chain A, interferon-inducible GTPaseMus musculus (house mouse)Kd0.640014
Chain A, ras-related C3 botulinum toxin substrate 1 isoform Rac1bHomo sapiens (human)Kd0.001612
Chain A, Uracil PhosphoribosyltransferaseToxoplasma gondiiKd465.000011
Chain B, Uracil PhosphoribosyltransferaseToxoplasma gondiiKd465.000011
Chain C, Uracil PhosphoribosyltransferaseToxoplasma gondiiKd465.000011
P2Y purinoceptor 6Homo sapiens (human)EC5045.000011
Ras-related protein Rab-7aHomo sapiens (human)Kd0.217348