Page last updated: 2024-12-06

porphine

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

Porphine is a macrocyclic organic compound that forms the basis of the porphyrin class. It is a key component of many important biological molecules, including heme, chlorophyll, and vitamin B12. Porphine itself is not found naturally, but its derivatives are essential for life.

Porphine is a planar molecule with a central cavity that can bind metal ions. This ability to coordinate metals is what makes porphyrins so important in biology. For example, heme, which is a porphyrin derivative, binds iron and is the active component of hemoglobin, the molecule that transports oxygen in the blood. Chlorophyll, another porphyrin derivative, binds magnesium and is essential for photosynthesis.

The synthesis of porphine involves a complex series of reactions that can be challenging to carry out in the laboratory. However, porphyrins can be synthesized by a variety of methods, including the condensation of pyrrole derivatives and the oxidation of tetrapyrroles.

Porphine is studied extensively because of its importance in biology and its potential applications in medicine. For example, porphyrins are being investigated as photosensitizers in photodynamic therapy, a cancer treatment that uses light to activate a drug. Porphyrins are also being studied as catalysts in organic chemistry.

The synthesis of porphine involves the condensation of four pyrrole molecules with four formaldehyde molecules. This reaction is typically carried out in the presence of acid, which promotes the formation of the porphine ring.

The structure of porphine is highly conjugated, meaning that it contains a network of alternating single and double bonds. This conjugation gives porphine its characteristic intense color and its strong absorption of light in the visible region of the electromagnetic spectrum.

The central cavity of porphine can bind a variety of metal ions, including iron, cobalt, nickel, copper, and zinc. This ability to coordinate metals is what makes porphyrins so important in biology. For example, heme, which is a porphyrin derivative, binds iron and is the active component of hemoglobin, the molecule that transports oxygen in the blood. Chlorophyll, another porphyrin derivative, binds magnesium and is essential for photosynthesis.'

porphine: structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID66868
CHEBI ID174230
CHEBI ID8337
SCHEMBL ID611755
SCHEMBL ID15809
MeSH IDM0278614

Synonyms (30)

Synonym
pentaporphyrin i
CHEBI:174230
21,22-dihydroporphyrin
(5z,10z,14z,19z)-21,23-dihydroporphyrin
porphine
21,22,23,24-tetraazapentacyclo[16.2.1.1<3,6>.1<8,11>.1<13,16>]tetracosa-1(21),2,4,6,8(23),9,11,13,15,17,19-undecaene
CHEBI:8337
21h,23h-porphin
21h,23h-porphine
101-60-0
porphyrin
C05113
2,10-dimethoxy-6a-aporphine-1,9-diol
unii-604bgd9j5b
604bgd9j5b ,
einecs 202-958-7
porphine [mi]
SCHEMBL611755
RKCAIXNGYQCCAL-UHFFFAOYSA-N
SCHEMBL15809
DTXSID6059235
hydroporphyrin
J-000449
2,10-dimethoxy-6alpha-aporphine-1,9-diol
delta-isoboldine
doi:10.14272/rkcaixngyqccal-cevvszfksa-n.1
10.14272/RKCAIXNGYQCCAL-CEVVSZFKSA-N.1
a porphyrin
porphyrin-
23h-porphyrin

Research Excerpts

Compound-Compound Interactions

ExcerptReferenceRelevance
"An assessment study is presented about energy decomposition analysis (EDA) in combination with DFT including revised dispersion correction (DFT-D3) with Slater-type orbital (STO) basis set."( The assessment and application of an approach to noncovalent interactions: the energy decomposition analysis (EDA) in combination with DFT of revised dispersion correction (DFT-D3) with Slater-type orbital (STO) basis set.
Chen, L; Feng, H; Gao, W; Xuan, X, 2012
)
0.38
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Pathways (7)

PathwayProteinsCompounds
Transport of small molecules39295
ABC-family proteins mediated transport7711
Mitochondrial ABC transporters46
Disease1278231
Disorders of transmembrane transporters10243
ABC transporter disorders5710
Defective ABCB6 causes MCOPCB703

Research

Studies (79)

TimeframeStudies, This Drug (%)All Drugs %
pre-19906 (7.59)18.7374
1990's3 (3.80)18.2507
2000's30 (37.97)29.6817
2010's35 (44.30)24.3611
2020's5 (6.33)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 43.45

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be strong demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index43.45 (24.57)
Research Supply Index4.39 (2.92)
Research Growth Index5.50 (4.65)
Search Engine Demand Index62.74 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (43.45)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (1.25%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other79 (98.75%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]