Menkes Kinky Hair Syndrome

An inherited disorder of copper metabolism transmitted as an X-linked trait and characterized by the infantile onset of HYPOTHERMIA, feeding difficulties, hypotonia, SEIZURES, bony deformities, pili torti (twisted hair), and severely impaired intellectual development. Defective copper transport across plasma and endoplasmic reticulum membranes results in copper being unavailable for the synthesis of several copper containing enzymes, including PROTEIN-LYSINE 6-OXIDASE; CERULOPLASMIN; and SUPEROXIDE DISMUTASE. Pathologic changes include defects in arterial elastin, neuronal loss, and gliosis. (From Menkes, Textbook of Child Neurology, 5th ed, p125)

Synonym
Menkes Kinky Hair Syndrome

Excerpt	Reference
"Menkes kinky hair syndrome is an X-linked neurodegenerative disorder, causing tissue-specific increases in copper and metallothionein content."	( Karin, M; O'Toole, C; Packman, S; Palmiter, RD, 1987)

Excerpt	Reference
"In the untreated infant with Menkes Kinky Hair Syndrome, copper concentrations in brain and liver are deficient, while excessive copper accumulates in other tissues."	( Garnica, AD, 1984)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	205 (33.72)	23.3326
1990's	164 (26.97)	12.5806
2000's	124 (20.39)	18.1394
2010's	103 (16.94)	28.8240
2020's	12 (1.97)	9.53

Drug	Relationship Strength	Studies	Trials
ammonium hydroxide	low	1	0
carnitine	low	1	0
catechol	low	3	0
chlorine	low	1	0
salicylic acid	low	3	0
3,4-dihydroxyphenylacetic acid	low	3	0
lactic acid	low	5	0
glutaric acid	low	1	0
hydrogen carbonate	low	1	0
dihydroxyphenylalanine	low	4	0
nickel	low	1	0
pqq cofactor	low	1	0
putrescine	low	1	0
pyridoxal	low	1	0
pyruvic acid	low	3	0
spermidine	low	1	0
spermine	low	1	0
uric acid	low	1	0
urea	low	1	0
vanilmandelic acid	medium	6	1
mercaptoethanol	low	1	0
aminopropionitrile	low	1	0
p-chloromercuribenzoic acid	low	3	0
homovanillic acid	low	5	0
carbonyl cyanide m-chlorophenyl hydrazone	low	2	0
clioquinol	low	1	0
disulfiram	medium	4	1
valproic acid	low	1	0
fentanyl	low	1	0
iodoacetamide	low	1	0
2-propanol	low	3	0
nocodazole	low	1	0
ethylmaleimide	low	1	0
pamidronate	medium	1	1
phenobarbital	low	1	0
carbamylhydrazine	low	1	0
sevoflurane	low	2	0
hydroxyproline	low	3	0
penicillamine	low	5	0
serine	low	1	0
lysine	low	1	0
cyanides	low	1	0
carbostyril	low	1	0
edetic acid	low	2	0
tyrosine	low	1	0
leucine	low	4	0
methionine	low	1	0
phenylalanine	low	1	0
colchicine	low	1	0
cycloheximide	low	2	0
histidine	low	44	0
tryptophan	low	1	0
arginine	low	1	0
taurocholic acid	low	1	0
nitrilotriacetic acid	low	1	0
cupric acetate	low	1	0
ditiocarb	low	2	0
cyclopentane	low	1	0
hydrazine	low	3	0
methoxyhydroxyphenylglycol	low	4	0
dicyclohexylcarbodiimide	low	1	0
ethylnitrosourea	low	1	0
arsenic trioxide	low	1	0
d-alpha tocopherol	low	2	0
tocopherols	low	1	0
dithiothreitol	low	1	0
manganese	low	3	0
mercury	low	1	0
molybdenum	low	5	0
silver	low	5	0
cadmium	low	15	0
chromium	low	1	0
cupric chloride	low	11	0
phosphine	low	1	0
copper sulfate	low	4	0
fluorine	low	1	0
cadmium chloride	low	1	0
trolamine salicylate	low	1	0
dihydroxyethyldithiocarbamate	low	1	0
transferrin	low	1	0
glutamic acid	low	1	0
remifentanil	low	1	0
cuprous chloride	low	1	0
1,7-phenanthroline	low	1	0
3,4-dihydroxyphenylglycol	low	4	0
homocysteine	low	1	0
droxidopa	low	2	0
cobalt	low	3	0
deoxypyridinoline	low	1	0
6-hydroxydopa quinone	low	1	0
proline	low	1	0
copper bis(histidinate)	low	27	0
bathocuproine disulfonate	low	1	0
biotin	low	1	0
elesclomol	low	3	0
elastin	low	10	0
ouabain	low	1	0
inositol 3-phosphate	low	1	0
digitoxin	low	1	0
sodium arsenite	low	1	0
hydroxylysine	low	2	0
tryptophan tryptophylquinone	low	1	0
cystine	low	1	0
dimethyldithiocarbamate	low	1	0
brefeldin a	low	2	0
arsenic	low	2	0
sulfur	low	1	0
cysteine	low	7	0
phosphorus	low	1	0
neuromedin c	low	1	0
selenium	low	6	0
bafilomycin a1	low	1	0
i(3)so3-galactosylceramide	low	1	0
staurosporine	low	1	0
phosphocreatine	low	1	0
2-phenylbenzothiazole	low	1	0
acid phosphatase	low	1	0
desmosine	low	1	0
oligonucleotides	low	1	0
c-peptide	low	1	0
calpain	low	1	0
4,4-difluoro-4-bora-3a,4a-diaza-s-indacene	low	1	0
piperidines	low	1	0
ascorbic acid	low	3	0
tetracycline	low	1	0
salicylates	low	1	0
lysine tyrosylquinone	low	1	0
vitamin b 12	low	1	0
metallothionein	low	50	0

Protein Targets (854)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	14	0	0	14
geminin	21	0	0	21
lamin isoform A-delta10	19	0	0	19
Guanine nucleotide-binding protein G	1	0	0	1
hypoxia-inducible factor 1 alpha subunit	8	0	0	8
RAR-related orphan receptor gamma	20	0	0	20
GLI family zinc finger 3	15	0	0	15
AR protein	22	0	0	22
aldehyde dehydrogenase 1 family, member A1	15	0	0	15
retinoic acid nuclear receptor alpha variant 1	22	0	0	22
retinoid X nuclear receptor alpha	15	0	0	15
estrogen nuclear receptor alpha	30	0	0	30
peroxisome proliferator-activated receptor delta	13	0	0	13
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	13	0	0	13
activating transcription factor 6	12	0	0	12
v-jun sarcoma virus 17 oncogene homolog (avian)	14	0	0	14
Histone H2A.x	12	0	0	12
thyroid hormone receptor beta isoform a	8	0	0	8
heat shock protein beta-1	8	0	0	8
nuclear factor erythroid 2-related factor 2 isoform 1	21	0	0	21
Voltage-dependent calcium channel gamma-2 subunit	11	0	0	11
Glutamate receptor 2	12	2	1	15
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	12	0	0	12
Chain A, HADH2 protein	8	0	0	8
Chain B, HADH2 protein	8	0	0	8
Chain A, JmjC domain-containing histone demethylation protein 3A	7	0	0	7
Chain A, 2-oxoglutarate Oxygenase	10	0	0	10
Chain A, Protocatechuate 3,4-dioxygenase	0	0	1	1
Chain M, Protocatechuate 3,4-dioxygenase	0	0	1	1
Olfactory receptor class A-like protein 1	0	0	1	1
Luciferase	12	0	0	12
endonuclease IV	4	0	0	4
thioredoxin reductase	19	0	0	19
RGS12	2	0	0	2
phosphopantetheinyl transferase	13	0	0	13
NFKB1 protein, partial	8	0	0	8
GLS protein	13	0	0	13
TDP1 protein	17	0	0	17
Microtubule-associated protein tau	13	0	0	13
Thrombopoietin	11	0	0	11
alkaline phosphatase, intestinal	0	0	1	1
thioredoxin glutathione reductase	8	0	0	8
apical membrane antigen 1, AMA1	4	0	0	4
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	7	0	0	7
thyroid stimulating hormone receptor	12	0	0	12
hypothetical protein, conserved	4	0	0	4
regulator of G-protein signaling 4	10	0	0	10
euchromatic histone-lysine N-methyltransferase 2	27	0	0	27
Bloom syndrome protein isoform 1	9	0	0	9
lysosomal alpha-glucosidase preproprotein	2	0	0	2
peripheral myelin protein 22 isoform 1	9	0	0	9
alkaline phosphatase, tissue-nonspecific isozyme isoform 1 preproprotein	0	1	0	1
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	9	0	0	9
intestinal alkaline phosphatase precursor	0	1	0	1
chromobox protein homolog 1	15	0	0	15
guanine nucleotide-binding protein G(i) subunit alpha-1 isoform 1	2	0	0	2
DNA polymerase beta	4	0	0	4
flap endonuclease 1	10	0	0	10
DNA polymerase iota isoform a (long)	9	0	0	9
M-phase phosphoprotein 8	8	0	0	8
alkaline phosphatase, germ cell type preproprotein	0	0	1	1
POsterior Segregation	0	0	1	1
muscarinic acetylcholine receptor M1	10	0	0	10
Prolyl 4-hydroxylase subunit alpha-1	0	3	0	3
Sodium-dependent noradrenaline transporter	0	2	1	3
Zinc finger protein mex-5	0	0	1	1
ATP-dependent phosphofructokinase	14	0	0	14
ATAD5 protein, partial	13	0	0	13
Lysyl oxidase homolog 2	0	1	0	1
arylsulfatase A	7	0	0	7
Protein-lysine 6-oxidase	0	2	0	2
Protein-lysine 6-oxidase	0	1	0	1
Lysyl oxidase homolog 2	0	1	0	1
Lysyl oxidase homolog 3	0	2	0	2
Lysyl oxidase homolog 4	0	2	0	2
Lysyl oxidase homolog 2	0	2	0	2
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	2	2
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	2	2
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	2	2
alpha-galactosidase	3	0	0	3
cytochrome P450 2C19 precursor	6	0	0	6
lethal factor (plasmid)	14	0	0	14
Cytochrome P450 3A4	0	1	0	2
Nitric oxide synthase, endothelial	0	0	0	2
Nitric oxide synthase, brain	0	0	0	1
Nitric oxide synthase, brain	0	0	0	1
Nitric oxide synthase, inducible	0	0	0	1
Nitric oxide synthase, inducible	0	0	1	3
Cationic amino acid transporter 3	0	2	0	2
glucocorticoid receptor [Homo sapiens]	22	0	0	22
peroxisome proliferator activated receptor gamma	15	0	0	15
nuclear receptor subfamily 1, group I, member 2	3	0	0	3
thyroid hormone receptor beta isoform 2	14	0	0	14
Cellular tumor antigen p53	17	0	0	17
Chain A, Hyaluronidase, phage associated	0	1	0	1
acetylcholinesterase	7	0	0	7
cytochrome P450 family 3 subfamily A polypeptide 4	9	0	0	9
estrogen-related nuclear receptor alpha	22	0	0	22
vitamin D (1,25- dihydroxyvitamin D3) receptor	12	0	0	12
IDH1	10	0	0	10
nuclear factor erythroid 2-related factor 2 isoform 2	7	0	0	7
lethal(3)malignant brain tumor-like protein 1 isoform I	2	0	0	2
Polyphenol oxidase 2	0	2	0	4
Pancreatic alpha-amylase	0	2	0	2
Albumin	0	1	0	1
Urease	0	1	0	1
Prolyl 4-hydroxylase subunit alpha-1	0	0	0	1
Tyrosinase	0	1	0	1
Alpha-2B adrenergic receptor	0	2	1	3
Spike glycoprotein	3	1	1	5
Hyaluronate lyase	0	1	0	1
Prolyl hydroxylase EGLN2	0	0	0	1
Egl nine homolog 1	0	0	0	1
Prolyl hydroxylase EGLN3	0	0	0	1
Hypoxia-inducible factor 1-alpha inhibitor	0	0	0	1
Solute carrier family 23 member 1	0	1	0	1
Adenosine receptor A3	0	3	0	3
P2X purinoceptor 3	0	1	0	1
V-type proton ATPase subunit S1	0	1	0	1
Vacuolar proton pump subunit B	0	1	0	1
Chain A, Avidin	0	0	1	1
Chain A, Protein (streptavidin)	0	0	1	1
Chain B, Protein (streptavidin)	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain D, Streptavidin	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain D, Streptavidin	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain D, Streptavidin	0	0	1	1
Chain A, Streptavidin Complex With Biotin	0	0	1	1
Chain D, Circularly Permuted Core-streptavidin E51/a46	0	0	1	1
Chain A, Core-streptavidin	0	0	1	1
Chain D, Core-streptavidin	0	0	1	1
Chain A, Core-streptavidin	0	0	1	1
Chain D, Core-streptavidin	0	0	1	1
Chain A, Core-streptavidin	0	0	1	1
Chain D, Core-streptavidin	0	0	1	1
Chain A, Core-streptavidin	0	0	1	1
Chain D, Core-streptavidin	0	0	1	1
Chain A, Avidin	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain B, Streptavidin	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain B, Streptavidin	0	0	1	1
nonstructural protein 1	0	2	0	2
green fluorescent protein, partial	0	1	0	1
vitamin D3 receptor isoform VDRA	7	0	0	7
insulin-degrading enzyme isoform 1	0	0	1	1
Streptavidin	0	0	1	1
Receptor-type tyrosine-protein phosphatase beta	0	0	0	1
PAX8	0	0	0	2
USP1 protein, partial	7	0	0	7
Smad3	8	0	0	8
67.9K protein	5	0	0	5
NPC intracellular cholesterol transporter 1 precursor	6	0	0	6
major prion protein preproprotein Prp precursor	0	1	0	1
nuclear receptor subfamily 0 group B member 1	0	3	0	3
ras-related protein Rab-9A	6	0	0	6
steroidogenic factor 1	0	3	0	3
urokinase-type plasminogen activator precursor	5	0	0	5
plasminogen precursor	5	0	0	5
urokinase plasminogen activator surface receptor precursor	5	0	0	5
Amine oxidase [flavin-containing] A	0	4	0	4
Amine oxidase [flavin-containing] B	0	2	0	2
Chain A, PAPAIN	1	0	0	1
Chain A, Putative fructose-1,6-bisphosphate aldolase	8	0	0	8
Chain A, Ferritin light chain	4	0	0	4
Chain A, Cruzipain	5	0	0	5
15-lipoxygenase, partial	9	0	0	9
SMAD family member 2	7	0	0	7
SMAD family member 3	7	0	0	7
estrogen receptor 2 (ER beta)	12	0	0	12
nuclear receptor subfamily 1, group I, member 3	15	0	0	15
progesterone receptor	12	0	0	12
farnesoid X nuclear receptor	12	0	0	12
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	8	0	0	8
histone deacetylase 9 isoform 3	5	0	0	5
nuclear receptor ROR-gamma isoform 1	9	0	0	9
survival motor neuron protein isoform d	6	0	0	6
cytochrome P450 3A4 isoform 1	9	0	0	9
Gamma-aminobutyric acid receptor subunit pi	9	0	0	9
Polyunsaturated fatty acid lipoxygenase ALOX15B	8	0	0	8
Gamma-aminobutyric acid receptor subunit beta-1	9	0	0	9
Gamma-aminobutyric acid receptor subunit delta	9	0	0	9
Gamma-aminobutyric acid receptor subunit gamma-2	9	0	0	9
Gamma-aminobutyric acid receptor subunit alpha-5	9	0	0	9
Gamma-aminobutyric acid receptor subunit alpha-3	9	0	0	9
Gamma-aminobutyric acid receptor subunit gamma-1	9	0	0	9
Gamma-aminobutyric acid receptor subunit alpha-2	9	0	0	9
Gamma-aminobutyric acid receptor subunit alpha-4	9	0	0	9
Gamma-aminobutyric acid receptor subunit gamma-3	9	0	0	9
Gamma-aminobutyric acid receptor subunit alpha-6	9	0	0	9
Histamine H2 receptor	10	0	0	10
Gamma-aminobutyric acid receptor subunit alpha-1	9	0	0	9
Gamma-aminobutyric acid receptor subunit beta-3	9	0	0	9
Gamma-aminobutyric acid receptor subunit beta-2	9	0	0	9
Inositol monophosphatase 1	3	0	0	3
GABA theta subunit	9	0	0	9
ATPase family AAA domain-containing protein 5	10	0	0	10
Ataxin-2	11	0	0	11
Gamma-aminobutyric acid receptor subunit epsilon	9	0	0	9
CDGSH iron-sulfur domain-containing protein 1	0	2	0	2
Chain A, serum paraoxonase	0	1	0	1
DNA polymerase kappa isoform 1	5	0	0	5
Carbonic anhydrase 12	0	5	0	10
Carbonic anhydrase 1	0	11	0	18
Carbonic anhydrase 2	0	11	0	18
Carbonic anhydrase 3	0	5	0	10
Neutrophil cytosol factor 1	0	1	0	1
Carbonic anhydrase 4	0	8	0	13
Carbonic anhydrase 6	0	6	0	11
Carbonic anhydrase 5A, mitochondrial	0	5	0	10
Carbonic anhydrase 7	0	5	0	10
Carbonic anhydrase 9	0	5	0	10
Carbonic anhydrase 13	0	1	0	3
Poly [ADP-ribose] polymerase tankyrase-2	0	1	0	1
Carbonic anhydrase 14	0	5	0	10
Carbonic anhydrase 5B, mitochondrial	0	5	0	9
Solute carrier family 22 member 5	0	0	0	1
Solute carrier family 22 member 5	0	0	0	1
Bile salt export pump	0	12	0	13
Solute carrier family 22 member 16	0	0	0	1
Solute carrier family 22 member 21	0	0	0	1
Solute carrier family 22 member 5	0	0	0	1
Chain A, Beta-lactamase	7	0	0	7
Chain A, ATP-DEPENDENT DNA HELICASE Q1	4	0	0	4
Chain A, Neutrophil gelatinase-associated lipocalin	0	0	1	1
interleukin 8	5	0	0	5
Nrf2	2	0	0	2
pregnane X nuclear receptor	12	0	0	12
Parkin	1	0	0	1
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	1	0	0	1
aryl hydrocarbon receptor	7	0	0	7
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	4	0	0	4
serine/threonine-protein kinase mTOR isoform 1	4	0	0	4
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	2	0	0	2
DNA polymerase eta isoform 1	1	0	0	1
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	2	0	0	2
Epidermal growth factor receptor	0	2	0	2
Tyrosine-protein kinase Fyn	0	1	0	1
3-dehydroquinate synthase	0	1	0	2
Polyunsaturated fatty acid lipoxygenase ALOX15	0	2	0	2
Matrix metalloproteinase-9	0	1	0	1
Potassium-transporting ATPase subunit beta	0	0	0	1
Potassium-transporting ATPase alpha chain 1	0	0	0	1
Adenosine receptor A1	0	1	0	4
Adenosine receptor A2a	0	1	0	4
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	0	1	0	1
D(1A) dopamine receptor	1	0	0	1
Nuclear receptor ROR-gamma	6	0	0	6
Autoinducer 2-binding periplasmic protein LuxP	0	1	0	1
E3 ubiquitin-protein ligase Mdm2	0	1	0	1
Glutaminyl-peptide cyclotransferase	0	2	0	2
Arginase-1	0	1	0	1
Carbonic anhydrase	0	2	0	2
Carbonic anhydrase 3	0	2	0	2
Carbonic anhydrase 15	0	8	0	12
Carbonic anhydrase 13	0	4	0	8
phosphoglycerate kinase	1	0	0	1
Carbonic anhydrase	0	3	0	7
glp-1 receptor, partial	3	0	0	3
mu opioid receptor, partial	0	0	1	1
90-kda heat shock protein beta HSP90 beta, partial	0	2	0	2
Fumarate hydratase	6	0	0	6
nonstructural protein 1	3	0	0	3
polyprotein	6	0	0	6
bromodomain adjacent to zinc finger domain 2B	3	0	0	3
LAP4	0	0	1	1
MEP2	0	0	1	1
cellular tumor antigen p53 isoform a	7	0	0	7
polyunsaturated fatty acid lipoxygenase ALOX12	4	0	0	4
delta-type opioid receptor	0	1	1	2
kappa-type opioid receptor isoform 1	0	1	0	1
potassium voltage-gated channel subfamily H member 2 isoform d	7	0	0	7
huntingtin isoform 2	4	0	0	4
mitogen-activated protein kinase 1	3	0	0	3
nuclear factor NF-kappa-B p105 subunit isoform 1	2	0	0	2
ubiquitin carboxyl-terminal hydrolase 2 isoform a	2	0	0	2
heat shock protein HSP 90-alpha isoform 2	0	2	0	5
peripheral myelin protein 22	7	0	0	7
DNA dC->dU-editing enzyme APOBEC-3F isoform a	1	0	0	1
Histone deacetylase 3	0	3	0	3
ATP-binding cassette sub-family C member 3	0	5	0	5
Multidrug resistance-associated protein 4	0	6	0	6
Amyloid-beta precursor protein	2	2	0	4
Integrin beta-3	4	0	1	5
Integrin alpha-IIb	4	0	1	5
Botulinum neurotoxin type A	0	1	0	1
Spike glycoprotein	0	1	0	1
Alpha-1B adrenergic receptor	0	3	1	4
Catechol O-methyltransferase	0	1	0	1
Alpha-1D adrenergic receptor	0	1	1	2
Alpha-synuclein	4	1	0	5
Alpha-1A adrenergic receptor	0	3	1	4
Histone deacetylase 4	0	3	0	3
Disintegrin and metalloproteinase domain-containing protein 17	2	0	0	2
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
TAR DNA-binding protein 43	3	0	0	3
Histone deacetylase 1	0	3	0	3
Beta-galactosidase	0	0	1	1
Histone deacetylase 7	0	3	0	3
Histone deacetylase 2	0	3	0	3
Canalicular multispecific organic anion transporter 1	0	5	0	5
Polyamine deacetylase HDAC10	0	3	0	3
Histone deacetylase 11	0	3	0	3
Histone deacetylase 8	0	3	0	3
Histone deacetylase 6	0	3	0	3
Histone deacetylase 9	0	3	0	3
Histone deacetylase 5	0	3	0	3
HSP40, subfamily A [Plasmodium falciparum 3D7]	0	0	0	1
heat shock protein 90, putative	0	0	0	3
pregnane X receptor	5	0	0	5
PPM1D protein	6	0	0	6
glucocerebrosidase	2	0	0	2
cytochrome P450 2D6 isoform 1	2	0	0	2
cytochrome P450 2C9 precursor	6	0	0	6
atrial natriuretic peptide receptor 2 precursor	3	0	0	3
muscleblind-like protein 1 isoform 1	2	0	0	2
caspase-1 isoform alpha precursor	2	0	0	2
neuropeptide S receptor isoform A	5	0	0	5
Solute carrier family 22 member 3	0	1	0	1
Interferon beta	7	0	0	7
Tubulin alpha-1A chain	0	3	1	4
Tubulin beta chain	0	3	1	4
Plasma kallikrein	0	0	0	5
Tubulin beta-4A chain	0	3	3	7
ATP-dependent translocase ABCB1	0	1	0	1
Tubulin beta chain	0	3	3	7
ATP-dependent translocase ABCB1	0	2	0	3
Tubulin alpha-3C chain	0	3	3	7
Serine/threonine-protein kinase pim-1	0	1	0	1
ATP-dependent translocase ABCB1	0	1	0	1
Tubulin alpha-1B chain	0	3	3	7
Tubulin alpha-4A chain	0	3	3	7
Tubulin beta-4B chain	0	3	3	7
Vesicular acetylcholine transporter	0	1	0	1
Tubulin beta-3 chain	0	3	3	7
Tubulin beta-2A chain	0	3	3	7
Tubulin polymerization-promoting protein	0	0	1	1
Tubulin beta-8 chain	0	3	3	7
Tubulin beta-2B chain	0	3	0	4
Tubulin alpha-3E chain	0	3	3	7
Tubulin alpha-1A chain	0	3	3	7
Similar to alpha-tubulin isoform 1	0	2	0	3
Similar to alpha-tubulin isoform 1	0	2	0	3
CREB-binding protein	2	0	0	2
Tubulin alpha-1C chain	0	3	3	7
Tubulin beta-6 chain	0	3	3	7
Tubulin beta-2B chain	0	3	3	7
Tubulin beta-1 chain	0	3	3	7
EWS/FLI fusion protein	5	0	0	5
P53	1	0	0	1
RPL19A	0	0	1	1
Spike glycoprotein	0	1	1	2
Replicase polyprotein 1ab	0	1	1	2
transactivating tegument protein VP16 [Human herpesvirus 1]	0	1	0	1
COUP transcription factor 2 isoform a	0	1	0	1
Transmembrane protease serine 2	0	1	1	2
Glucose transporter	0	1	0	1
Hexose transporter 1	0	1	0	1
Procathepsin L	0	1	1	2
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	1
Replicase polyprotein 1a	0	1	1	2
Replicase polyprotein 1ab	0	1	1	2
Replicase polyprotein 1ab	0	2	1	3
Replicase polyprotein 1ab	0	4	1	5
Solute carrier family 2, facilitated glucose transporter member 1	0	1	0	1
Eukaryotic initiation factor 4A-I	0	1	0	1
Peptidyl-prolyl cis-trans isomerase FKBP1A	0	2	0	2
Peptidyl-prolyl cis-trans isomerase FKBP3	0	1	0	1
Peptidyl-prolyl cis-trans isomerase FKBP4	0	1	0	1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	0	1	0	1
Hypoxia-inducible factor 1-alpha	0	1	0	1
Endothelial PAS domain-containing protein 1	0	1	0	1
Angiotensin-converting enzyme 2	0	1	1	2
Peptidyl-prolyl cis-trans isomerase FKBP14	0	1	0	1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4	0	1	0	1
importin subunit beta-1 isoform 1	1	0	0	1
snurportin-1	1	0	0	1
GTP-binding nuclear protein Ran isoform 1	1	0	0	1
Rap guanine nucleotide exchange factor 3	2	0	0	2
Glutathione S-transferase P	0	1	0	1
Alpha-tocopherol transfer protein	0	0	1	1
STAT3, partial	0	2	0	2
thyroid stimulating hormone receptor	6	0	0	6
signal transducer and activator of transcription 1-alpha/beta isoform alpha	0	2	0	2
Sodium/potassium-transporting ATPase subunit alpha-1	0	3	0	4
Sodium/potassium-transporting ATPase subunit beta-1	0	3	0	4
Sodium/potassium-transporting ATPase subunit alpha-3	0	2	0	3
Sodium/potassium-transporting ATPase subunit beta-2	0	2	0	3
Sodium/potassium-transporting ATPase subunit alpha-2	0	3	0	4
Sodium/potassium-transporting ATPase subunit alpha-1	0	1	0	1
Sodium/potassium-transporting ATPase subunit beta-3	0	2	0	3
Sodium/potassium-transporting ATPase subunit gamma	0	2	0	3
Sodium/potassium-transporting ATPase subunit alpha-4	0	2	0	3
Solute carrier organic anion transporter family member 4C1	0	1	0	2
runt-related transcription factor 1 isoform AML1b	2	0	0	2
core-binding factor subunit beta isoform 2	2	0	0	2
Glutamate receptor 1	1	2	1	4
Glutamate receptor 3	1	2	1	4
Glutamate receptor 4	1	2	1	4
Caspase-7	1	0	0	1
caspase 7, apoptosis-related cysteine protease	3	0	0	3
G	2	0	0	2
cytochrome P450 2D6	2	0	0	2
pyruvate kinase	2	0	0	2
glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase	0	1	0	1
LacZ protein (plasmid)	0	0	1	1
caspase-3	3	0	0	3
thyrotropin-releasing hormone receptor	1	0	0	1
Caspase-7	1	0	0	1
beta-2 adrenergic receptor	2	0	0	2
type-1 angiotensin II receptor	0	1	0	1
D(1A) dopamine receptor	2	0	0	2
atrial natriuretic peptide receptor 1 precursor	3	0	0	3
perilipin-5	0	1	0	1
glucose-6-phosphate 1-dehydrogenase isoform b	0	1	0	1
perilipin-1	0	1	0	1
caspase-3	1	0	0	1
polypyrimidine tract-binding protein 1 isoform a	1	0	0	1
serine/threonine-protein kinase PLK1	3	0	0	3
apelin receptor	0	1	0	1
histone-lysine N-methyltransferase 2A isoform 2 precursor	2	0	0	2
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform a	0	1	0	1
Vpr	2	0	0	2
histone acetyltransferase KAT2A isoform 1	9	0	0	9
bifunctional UDP-N-acetylglucosamine pyrophosphorylase/glucosamine-1-phosphate N-acetyltransferase	0	1	0	1
pyruvate kinase PKM isoform b	2	0	0	2
Fatty-acid amide hydrolase 1	0	1	0	1
Transient receptor potential cation channel subfamily A member 1	0	0	2	2
Carbamate kinase	0	1	0	1
Retinal dehydrogenase 1	0	1	0	1
HLA class I histocompatibility antigen, B alpha chain	2	0	0	2
Aldehyde dehydrogenase, mitochondrial	0	1	0	1
Cytochrome P450 1A2	0	1	0	1
Aldo-keto reductase family 1 member B1	0	3	0	3
Alpha-2A adrenergic receptor	0	2	0	2
Ornithine decarboxylase	2	1	0	3
Fructose-1,6-bisphosphatase 1	0	1	0	1
D(2) dopamine receptor	0	3	0	3
D(1A) dopamine receptor	0	2	0	2
D(4) dopamine receptor	0	3	0	3
C-X-C chemokine receptor type 2	0	2	0	2
Mitogen-activated protein kinase 3	0	1	0	1
Lysine-specific demethylase 5A	0	1	0	1
Caspase-1	1	1	0	2
Mu-type opioid receptor	0	4	1	5
D(3) dopamine receptor	0	3	0	3
Kappa-type opioid receptor	0	4	0	4
5-hydroxytryptamine receptor 2B	0	4	0	4
C-C chemokine receptor type 2	0	2	0	2
5-hydroxytryptamine receptor 6	0	2	0	2
C-C chemokine receptor type 4	0	2	0	2
C-C chemokine receptor type 5	0	2	0	2
Gasdermin-D	0	2	0	2
Sodium-dependent dopamine transporter	0	4	0	4
NACHT, LRR and PYD domains-containing protein 3	0	1	0	1
Inositol hexakisphosphate kinase 1	2	0	0	2
Histone-lysine N-methyltransferase EHMT2	0	1	0	1
Monoglyceride lipase	0	2	0	2
Gasdermin-D	0	2	0	2
Histone-lysine N-methyltransferase EHMT1	0	1	0	1
cytochrome P450 2C9, partial	2	0	0	2
hypothetical protein CAALFM_CR05890CA	0	0	0	1
H3 histone acetyltransferase	0	0	0	1
large T antigen	0	2	0	2
Nuclear receptor subfamily 1 group I member 2	0	0	2	2
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Eyes absent homolog 2	0	1	0	1
Angiotensin-converting enzyme	0	2	0	2
Metallo-beta-lactamase VIM-13	0	1	0	1
Beta-lactamase	0	1	0	1
Beta-lactamase	0	1	0	1
Beta-lactamase VIM-1	0	1	0	1
Ghrelin O-acyltransferase	0	1	0	1
14 kDa phosphohistidine phosphatase	0	1	0	1
Solute carrier family 22 member 1	0	1	0	1
Delta-type opioid receptor	0	2	0	2
Delta-type opioid receptor	0	2	0	2
Mu-type opioid receptor	0	3	1	4
Kappa-type opioid receptor	0	1	0	1
Histamine H1 receptor	0	1	0	1
Delta-type opioid receptor	0	2	0	2
Kappa-type opioid receptor	0	2	0	2
Mu-type opioid receptor	0	1	0	1
Mu-type opioid receptor	0	2	0	2
Potassium voltage-gated channel subfamily H member 2	0	3	0	3
Sigma non-opioid intracellular receptor 1	0	4	0	4
Sigma non-opioid intracellular receptor 1	0	2	0	2
Sigma non-opioid intracellular receptor 1	0	1	0	1
Chain A, GLUTAMATE RECEPTOR SUBUNIT 2	0	1	0	1
Chain A, Glutamate Receptor Subunit 2	0	1	0	1
Chain B, Glutamate Receptor Subunit 2	0	1	0	1
Chain A, Slr1257 protein	0	0	1	1
Chain A, Glucosamine--fructose-6-phosphate aminotransferase [isomerizing]	0	1	0	1
Metabotropic glutamate receptor 8	0	2	0	2
Metabotropic glutamate receptor 6	0	1	1	3
Glutamate receptor ionotropic, NMDA 2D	0	1	0	1
Excitatory amino acid transporter 4	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	1	0	1
Glutathione reductase, mitochondrial	0	4	0	4
Bifunctional aspartokinase/homoserine dehydrogenase 1	0	1	0	1
Prothrombin	0	0	1	1
ATP-citrate synthase	0	1	0	1
Glutamate receptor ionotropic, kainate 1	0	2	1	3
Metabotropic glutamate receptor 1	0	1	1	2
Metabotropic glutamate receptor 2	0	0	1	1
Metabotropic glutamate receptor 3	0	0	1	1
Metabotropic glutamate receptor 4	0	1	1	2
Metabotropic glutamate receptor 5	0	0	1	1
Metabotropic glutamate receptor 6	0	0	1	1
Metabotropic glutamate receptor 7	0	0	1	1
Glutamate receptor ionotropic, NMDA 1	0	4	2	10
Glutamate receptor ionotropic, kainate 1	0	1	1	2
Metabotropic glutamate receptor 5	0	1	1	3
Glutamate receptor ionotropic, kainate 2	0	2	1	3
Glutamate receptor 1	0	2	1	3
Glutamate receptor 2	0	2	1	3
Glutamate receptor 3	0	1	1	2
Glutamate receptor ionotropic, kainate 3	0	2	0	2
Excitatory amino acid transporter 1	0	2	0	3
Excitatory amino acid transporter 2	0	2	0	3
Excitatory amino acid transporter 3	0	2	0	3
Metabotropic glutamate receptor 8	0	0	1	1
Glutamate receptor 4	0	2	1	3
Excitatory amino acid transporter 3	0	0	0	1
Glutamate racemase	0	0	0	1
Metabotropic glutamate receptor 8	0	1	1	2
Fatty-acid amide hydrolase 1	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	3	1	8
Glutamate receptor ionotropic, NMDA 2B	0	3	2	9
Glutamate receptor ionotropic, NMDA 2C	0	3	1	8
Glutamate receptor ionotropic, kainate 4	0	2	0	2
Glutamate carboxypeptidase 2	0	1	0	1
Glutamate receptor ionotropic, NMDA 1	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	1	0	1
Glutamate receptor ionotropic, kainate 2	0	1	1	2
Glutamate receptor ionotropic, kainate 3	0	1	0	1
Glutamate receptor ionotropic, NMDA 2B	0	1	1	2
Metabotropic glutamate receptor 1	0	1	1	3
Metabotropic glutamate receptor 2	0	1	1	3
Metabotropic glutamate receptor 7	0	1	1	3
Metabotropic glutamate receptor 3	0	1	1	3
Metabotropic glutamate receptor 4	0	1	1	3
Glutamate receptor ionotropic, NMDA 2C	0	1	0	1
Glutamate receptor ionotropic, kainate 5	0	1	0	1
Carbonic anhydrase-like protein, putative	0	0	0	5
Glutamate receptor ionotropic, NMDA 2D	0	3	1	8
Glutamate receptor ionotropic, kainate 5	0	2	0	2
Glutamate racemase	0	0	0	1
Prolyl 4-hydroxylase	0	2	0	2
Glutamate receptor ionotropic, NMDA 3A	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	3	1	8
Alpha-ketoglutarate-dependent dioxygenase FTO	0	2	0	2
Glutamate receptor ionotropic, NMDA 3A	0	3	1	8
Chain A, Protein (aspartate Aminotransferase)	0	0	1	1
Chain A, Aspartate Aminotransferase	0	0	1	1
Solute carrier family 22 member 6	0	2	0	4
Solute carrier family 22 member 20	0	3	0	3
Solute carrier family 22 member 6	0	3	0	3
Solute carrier family 22 member 7	0	0	0	1
Chain A, HISTIDINE-BINDING PROTEIN	0	0	1	1
Histidine-binding periplasmic protein	0	0	1	1
5-hydroxytryptamine receptor 1D	0	0	0	1
Carbonic anhydrase	0	0	0	4
Large neutral amino acids transporter small subunit 1	0	6	0	7
Carbonic anhydrase	0	0	0	4
Carbonic anhydrase	0	0	0	4
Carbonic anhydrase	0	0	0	4
Carbonic anhydrase	0	0	0	4
Carbonic anhydrase 4	0	0	0	1
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1	0	1	0	1
ClpP	1	0	0	1
Solute carrier family 22 member 8	0	1	0	2
Glutamine synthetase	0	1	0	1
Neutral amino acid transporter A	0	3	0	3
Asc-type amino acid transporter 1	0	1	0	1
Neutral amino acid transporter B(0)	0	3	0	3
Proton-coupled amino acid transporter 1	0	4	0	5
Amino acid transporter	0	3	0	3
Alcohol dehydrogenase E chain	0	1	0	1
Alcohol dehydrogenase S chain	0	1	0	1
Chain A, AMINOPEPTIDASE	0	2	0	2
Chain A, AMINOPEPTIDASE	0	2	0	2
Chain A, Leucine Aminopeptidase	0	1	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	3	0	3
Intestinal-type alkaline phosphatase	0	3	0	3
Phospholipase A-2-activating protein	0	3	0	3
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplast	0	1	0	1
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplast	0	1	0	1
Glutaminyl-peptide cyclotransferase	0	1	0	1
Chain A, Methionyl-tRNA synthetase	0	0	1	1
Chain A, Methionyl-tRNA synthetase	0	0	1	1
Chain A, Aminopeptidase	0	1	0	1
Chain A, Methionine aminopeptidase	0	1	0	1
S-ribosylhomocysteine lyase	0	1	0	1
Adenylate cyclase type 5	0	0	0	1
S-adenosylmethionine synthase isoform type-1	0	0	0	1
S-adenosylmethionine synthase isoform type-2	0	0	0	1
Fatty acid synthase	0	1	0	1
Chain A, Glutathione-requiring prostaglandin D synthase	0	1	0	1
Tyrosine-protein kinase ABL1	0	1	0	1
Adenosine receptor A2a	0	2	0	2
Adenosine receptor A1	0	2	0	2
Chain H, Igg2b-kappa 40-50 Fab (heavy Chain)	0	1	0	1
Chain L, Igg2b-kappa 40-50 Fab (light Chain)	0	1	0	1
Chain A, Na, K-ATPase alpha subunit	0	0	1	1
Kruppel-like factor 5	0	1	0	1
Solute carrier organic anion transporter family member 1A4	0	2	0	4
Solute carrier organic anion transporter family member 1A5	0	0	0	2
Sodium/potassium-transporting ATPase subunit alpha-1	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-2	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-3	0	1	0	1
Sodium/potassium-transporting ATPase subunit beta-1	0	1	0	1
Muscarinic acetylcholine receptor M1	0	1	0	1
Solute carrier organic anion transporter family member 1A1	0	1	0	3
Solute carrier organic anion transporter family member 1A2	0	0	0	2
Sodium/potassium-transporting ATPase subunit beta-3	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-4	0	1	0	1
metallo beta-lactamase	0	1	0	1
metallo-beta-lactamase IMP-1	0	1	0	1
DNA polymerase III, partial	1	0	0	1
luciferase	1	0	0	1
Type 1 InsP3 receptor isoform S2	1	0	0	1
2,3-bisphosphoglycerate-independent phosphoglycerate mutase	1	0	0	1
Beta lactamase (plasmid)	0	1	0	1
Geranylgeranyl pyrophosphate synthase	0	1	0	1
Farnesyl pyrophosphate synthase	0	2	0	2
Hypoxanthine-guanine phosphoribosyltransferase	0	1	0	1
Farnesyl pyrophosphate synthase	0	1	0	1
Bile salt export pump	0	3	0	4
Cystathionine gamma-lyase	0	2	0	2
Succinyl-diaminopimelate desuccinylase	0	1	0	1
Sodium channel protein type 1 subunit alpha	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	1	0	1
Sodium channel protein type 3 subunit alpha	0	1	0	1
Voltage-dependent calcium channel subunit alpha-2/delta-1	0	1	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	1	0	1
Intestinal-type alkaline phosphatase	0	1	0	1
5'-nucleotidase	0	1	0	1
E3 ubiquitin-protein ligase XIAP	0	1	0	1
SLC16A10 protein	0	0	0	3
Large neutral amino acids transporter small subunit 1	0	1	0	1
Monocarboxylate transporter 10	0	0	0	3
G-protein coupled receptor 35	0	1	1	2
Glutamate 5-kinase	0	0	0	1
Chain A, PUTRESCINE-BINDING PROTEIN	0	0	1	1
Chain A, S-ADENOSYLMETHIONINE DECARBOXYLASE ALPHA CHAIN	0	1	0	1
Chain B, S-ADENOSYLMETHIONINE DECARBOXYLASE BETA CHAIN	0	1	0	1
Chain A, S-ADENOSYLMETHIONINE DECARBOXYLASE ALPHA CHAIN	0	1	0	1
Chain B, S-ADENOSYLMETHIONINE DECARBOXYLASE BETA CHAIN	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	0	3	0	3
S-adenosylmethionine decarboxylase proenzyme	0	0	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	3	0	3
Pyridoxal kinase	0	0	0	1
Aldehyde oxidase	0	1	0	1
Monocarboxylate transporter 4	0	0	0	1
Monocarboxylate transporter 2	0	0	0	1
Monocarboxylate transporter 1	0	0	0	1
C-terminal-binding protein 2	0	1	0	1
Monocarboxylate transporter 2	0	1	0	1
Solute carrier organic anion transporter family member 2A1	0	1	0	1
Chain A, Lysr-type Regulatory Protein	0	0	1	1
Chain A, Lysr-type Regulatory Protein	0	0	1	1
Chain A, Lysr-type Regulatory Protein	0	0	1	1
Chain A, 146aa long hypothetical transcriptional regulator	0	0	1	1
Chain A, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain A, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain A, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain B, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain C, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain A, Anthranilate phosphoribosyltransferase	0	1	0	1
Anthranilate phosphoribosyltransferase	0	1	0	1
chaperonin-containing TCP-1 beta subunit homolog	1	0	0	1
Estrogen receptor beta	0	0	0	1
Inhibitor of nuclear factor kappa-B kinase subunit beta	0	0	0	1
Solute carrier family 22 member 6	0	2	0	2
5'-AMP-activated protein kinase subunit beta-2	0	0	0	1
Albumin	0	1	0	1
Polymerase acidic protein	0	0	1	1
Stromelysin-1	0	2	1	3
Tyrosine-protein phosphatase YopH	0	1	0	1
High mobility group protein B1	0	0	1	1
Aldo-keto reductase family 1 member B1	0	1	0	1
Tyrosine-protein phosphatase non-receptor type 1	0	1	0	3
Estrogen receptor	0	0	0	1
Acetylcholinesterase	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-1	0	0	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-2	0	0	0	1
Xanthine dehydrogenase/oxidase	0	1	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-1	0	0	0	1
Solute carrier family 22 member 7	0	0	0	1
Nicotinate phosphoribosyltransferase	0	1	0	1
Solute carrier family 22 member 8	0	2	0	3
Ubiquitin-like domain-containing CTD phosphatase 1	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-3	0	0	0	1
5'-AMP-activated protein kinase subunit gamma-2	0	0	0	1
5'-AMP-activated protein kinase subunit beta-1	0	0	0	1
Acetylcholinesterase	0	1	0	1
Pyruvate kinase PKM	0	1	1	2
Cholinesterase	0	1	0	1
DNA topoisomerase 2-alpha	0	2	0	2
Cannabinoid receptor 1	0	2	0	2
Sulfate anion transporter 1	0	0	0	1
dopamine D1 receptor	1	0	0	1
Caspase-2	0	0	1	1
Chain A, Ribosomal protein S6 kinase alpha-1	0	1	0	1
Chain X, Tyrosine-protein kinase Lyn	0	1	0	1
Chain A, Dual specificity protein kinase TTK	0	0	1	1
Chain A, Dual specificity protein kinase TTK	0	0	1	1
Sodium/bile acid cotransporter	0	0	0	1
ATP-binding cassette sub-family C member 3	0	0	0	1
Solute carrier organic anion transporter family member 2B1	0	0	0	1
Sodium-dependent dopamine transporter	0	1	0	1
Sodium/bile acid cotransporter	0	1	0	2
Ileal sodium/bile acid cotransporter	0	0	0	1
Solute carrier organic anion transporter family member 1A3	0	1	0	2
Ileal sodium/bile acid cotransporter	0	1	0	2
Sodium/bile acid cotransporter	0	1	0	2
Ileal sodium/bile acid cotransporter	0	0	0	1
G-protein coupled bile acid receptor 1	0	0	1	1
Solute carrier organic anion transporter family member	0	0	0	1
Solute carrier organic anion transporter family member 4A1	0	0	0	1
Multidrug resistance associated protein	0	1	0	2
Solute carrier organic anion transporter family member 1C1	0	1	0	1
Solute carrier organic anion transporter family member 2B1	0	0	0	1
Solute carrier organic anion transporter family member 1B3	0	0	0	1
Solute carrier organic anion transporter family member 1A1	0	0	0	1
Bile salt export pump	0	0	0	1
Solute carrier organic anion transporter family member 1B2	0	0	0	1
Solute carrier organic anion transporter family member 1B1	0	0	0	1
estrogen receptor beta isoform 1	0	1	0	1
tyrosine-protein phosphatase non-receptor type 7 isoform 2	0	1	0	1
Dihydroxyacetone phosphate acyltransferase	0	0	0	1
30S ribosomal protein S6	0	1	0	1
30S ribosomal protein S7	0	1	0	1
50S ribosomal protein L15	0	1	0	1
Tetracycline resistance protein, class B	0	0	0	1
Muscarinic acetylcholine receptor M2	0	1	0	1
72 kDa type IV collagenase	0	1	0	1
50S ribosomal protein L10	0	1	0	1
50S ribosomal protein L11	0	1	0	1
50S ribosomal protein L7/L12	0	1	0	1
50S ribosomal protein L19	0	1	0	1
50S ribosomal protein L1	0	1	0	1
50S ribosomal protein L20	0	1	0	1
50S ribosomal protein L27	0	1	0	1
50S ribosomal protein L28	0	1	0	1
50S ribosomal protein L29	0	1	0	1
50S ribosomal protein L31	0	1	0	1
50S ribosomal protein L31 type B	0	1	0	1
50S ribosomal protein L32	0	1	0	1
50S ribosomal protein L33	0	1	0	1
50S ribosomal protein L34	0	1	0	1
50S ribosomal protein L35	0	1	0	1
50S ribosomal protein L36	0	1	0	1
30S ribosomal protein S10	0	1	0	1
30S ribosomal protein S11	0	1	0	1
30S ribosomal protein S12	0	1	0	1
30S ribosomal protein S13	0	1	0	1
30S ribosomal protein S16	0	1	0	1
30S ribosomal protein S18	0	1	0	1
30S ribosomal protein S19	0	1	0	1
30S ribosomal protein S20	0	1	0	1
30S ribosomal protein S2	0	1	0	1
30S ribosomal protein S3	0	1	0	1
30S ribosomal protein S4	0	1	0	1
30S ribosomal protein S5	0	1	0	1
30S ribosomal protein S8	0	1	0	1
30S ribosomal protein S9	0	1	0	1
50S ribosomal protein L13	0	1	0	1
50S ribosomal protein L14	0	1	0	1
50S ribosomal protein L16	0	1	0	1
50S ribosomal protein L23	0	1	0	1
30S ribosomal protein S15	0	1	0	1
Multidrug transporter MdfA	0	1	0	1
50S ribosomal protein L17	0	1	0	1
50S ribosomal protein L21	0	1	0	1
50S ribosomal protein L30	0	1	0	1
50S ribosomal protein L6	0	1	0	1
30S ribosomal protein S14	0	1	0	1
30S ribosomal protein S17	0	1	0	1
30S ribosomal protein S1	0	1	0	1
50S ribosomal protein L18	0	1	0	1
Neutrophil collagenase	0	1	0	1
Collagenase 3	0	1	0	1
Cannabinoid receptor 1	0	1	0	1
50S ribosomal protein L2	0	1	0	1
50S ribosomal protein L3	0	1	0	1
50S ribosomal protein L24	0	1	0	1
50S ribosomal protein L4	0	1	0	1
50S ribosomal protein L22	0	1	0	1
50S ribosomal protein L5	0	1	0	1
30S ribosomal protein S21	0	1	0	1
50S ribosomal protein L25	0	1	0	1
50S ribosomal protein L36 2	0	1	0	1
Integrase	0	1	0	1
P2Y purinoceptor 12	0	1	0	1
Solute carrier family 22 member 11	0	0	0	1
Protein-arginine deiminase type-4	0	1	0	1
Solute carrier family 22 member 7	0	0	0	1
Chain A, Trp Rna-binding Attenuation Protein	0	0	1	1
Chain K, Trp Rna-binding Attenuation Protein	0	0	1	1
Chain B, tryptophanyl-tRNA synthetase	0	0	1	1
Chain C, Tryptophanyl-tRNA synthetase II	0	0	1	1
Dihydrofolate reductase	0	2	0	2
Myeloperoxidase	0	1	0	1
Indoleamine 2,3-dioxygenase 1	0	1	0	2
Substance-P receptor	0	1	0	1
Tryptophan 2,3-dioxygenase	0	1	0	2
Uracil nucleotide/cysteinyl leukotriene receptor	0	1	0	1
Tryprostatin B synthase	0	0	0	1
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	0	0	1	1
Chain A, CHORISMATE MUTASE	0	1	0	1
Chain A, TYROSYL-tRNA SYNTHETASE	0	0	1	1
Tubulin--tyrosine ligase	0	1	0	1
Taste receptor type 2 member 14	0	0	0	1
Urease subunit alpha	0	1	0	1
Urease subunit beta	0	1	0	1
Olfactory receptor 51E2	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Solute carrier family 2, facilitated glucose transporter member 9	0	1	1	2
Guanine deaminase	0	1	0	1
Cocaine esterase	0	1	0	1
UDP-glucuronosyltransferase 1A9	0	0	0	1
Cytochrome P450 2A6	0	1	0	1
Tissue factor	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
UDP-glucuronosyltransferase 2B7	0	1	0	2
UDP-glucuronosyltransferase 1-6	0	0	0	1
Liver carboxylesterase 1	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
Aldo-keto reductase family 1 member B7	0	1	0	1
NAD-dependent protein deacylase sirtuin-5, mitochondrial	0	1	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(1)

Research Excerpts

Overview

Treatment

Research

Studies (608)

Protein Targets (854)

Menkes Kinky Hair Syndrome

Synonyms(1)

Research Excerpts

Overview

Treatment

Research

Studies (608)

Drugs Studied (152)

Protein Targets (854)