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rat metabolite

Any mammalian metabolite produced during a metabolic reaction in rat (Rattus norvegicus).

ChEBI ID: 86264

Members (44)

MemberDefinitionClass
1-methylhypoxanthineA methylhypoxanthine that is hypoxanthine with the methyl group at position 1.1-methylhypoxanthine
1,2,3,4-tetrahydro-beta-carboline-3-carboxylic acidA member of the class of beta-carbolines that is 1,2,3,4-tetrahydro-beta-carboline substituted at position 3 by a carboxy group.1,2,3,4-tetrahydro-beta-carboline-3-carboxylic acid
2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridineAn imidazopyridine that is 1H--imidazo[4,5-b]pyridine which is substituted at positions 1, 2, and 6 by methyl, hydoxyamino, and phenyl groups, respectively. The active metabolite of the dietary carcinogen PhIP.N-hydroxy-PhIP
2-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinolineAn isoquinolinol that is norsalsolinol substituted by a methyl group at position 2. It is present in normal human brain and also identified in the cerebrospinal fluid of patients with Parkinson's disease.N-methylnorsalsolinol
2-nonanolA secondary alcohol that is nonane substituted by a hydroxy group at position 2.nonan-2-ol
2,3,4-trihydroxbenzophenoneA benzenetriol that is benzophenone in which one of the phenyl groups is substituted by hydroxy groups at positions 2, 3, and 4. It is a redox mediator.2,3,4-trihydroxbenzophenone
3-hydroxy-4-methoxyphenethylamineA monomethoxybenzene that is dopamine in which the hydroxy group at position 4 is replaced by a methoxy group.4-methoxytyramine
4-bromophenolA bromophenol containing only hydroxy and bromo substituents that are para to one another.4-bromophenol
4-heptanoneA dialkyl ketone that is heptane in which the two methylene protons at position 4 have been replaced by an oxo group.4-heptanone
4-methoxyestradiolA 17beta-hydroxy steroid that is 17beta-estradiol in which the hydrogen at position 4 has been replaced by a methoxy group.4-methoxy-17beta-estradiol
5-hydroxybenzimidazoleA member of the class of benzimidazoles that is 1H-benzimidazole carrying a single hydroxy substituent at position 5.5-hydroxybenzimidazole
5-methoxyindoleacetic acidA member of the class of indole-3-acetic acids in which the hydrogen at position 5 of indole-3-acetic acid has been replaced by a methoxy group.5-methoxyindole-3-acetic acid
5,15-dihydroxy-6,8,11,13-eicosatetraenoic acidA DiHETE that is (6E,8Z,11Z,13E)-icosatetraenoic acid in which the two hydroxy substituents are placed at the 5S- and 15S-positions.5(S),15(S)-DiHETE
7-hydroxydehydroepiandrosteroneAn androstanoid that is dehydroepiandrosterone carrying an additional hydroxy substituent at the 7alpha-position.7alpha-hydroxydehydroepiandrosterone
8-isoprostaglandin e2A prostanoid that is prostaglandin E2 having inverted stereochemistry at the 8-position.8-epi-prostaglandin E2
acetaminophen mercapturateAn S-substituted N-acetyl-L-cysteine in which the S-substitutuent is specified as 5-acetamido-2-hydroxyphenyl.S-(5-acetamido-2-hydroxyphenyl)-N-acetyl-L-cysteine
allocholic acidAn allo-bile acid that is 5alpha-cholan-24-oic acid bearing three alpha-hydroxy substituents at position 3, 7 and 12.allocholic acid
angiotensin iA nine amino acid peptide which is formed when angiotensin converting enzyme 2 (ACE2) hydrolyzes the carboxy terminal leucine from angiotensin I. It is a anti-cardiac hypertrophy agent.angiotensin (1-9) dizwitterion; angiotensin (1-9)
angiotensin iA peptide zwitterion that is the dizwitterionic form of angiotensin (1-9) having both carboxy groups deprotonated and the aspartyl amino group and arginine side-chain protonated. It is the major species at pH 7.3.angiotensin (1-9) dizwitterion; angiotensin (1-9)
benzohydrolA secondary alcohol that is diphenylmethane which carries a hydroxy group at position 1.diphenylmethanol
bradykinin, des-phe(8)-des-arg(9)-A seven-membered oligopeptide comprising Arg, Pro, Pro, Gly, Phe, Ser, and Pro residues joined in sequence by peptide bonds. It is a metabolite of bradykinin lacking the Phe residue at position 8 and the Arg residue at position 9.[des-Phe(8), des-Arg(9)]-bradykinin
columbianadinAn alpha,beta-unsaturated carboxylic ester obtained by formal condensation of the carboxy group of angelic acid with the hydroxy group of 2-[(8S)-2-oxo-8,9-dihydro-2H-furo[2,3-h][1]benzopyran-8-yl]propan-2-ol.columbianadin
cystathionine ketimineA 1-thia-4-azacyclohepta-3-ene-3,5-dicarboxylic acid that has R-configuration. It is cyclic sulfur-containing imino acid detected in bovine brain extracts.cystathionine ketimine
enkephalin, leucineA pentapeptide comprising L-tyrosine, glycine, glycine, L-phenylalanine and L-leucine residues joined in sequence by peptide linkages. It is an endogenous opioid peptide produced in vertebrate species, including rodents, primates and humans that results from decomposition of proenkephalin or dynorphin and exhibits antinociceptive properties.Leu-enkephalin zwitterion; Leu-enkephalin
epietiocholanoloneA 3beta-hydroxy steroid that is 5beta-androstane substituted by a hydroxy group at position 3beta and an oxo group at position 17. It is a metabolite of testosterone.epietiocholanolone
erucyl amideA primary fatty amide resulting from the formal condensation of the carboxy group of erucic acid with ammonia. It is commonly used as a slip additive in the plastic manufacturing industry.erucamide
glaucineAn aporphine alkaloid that is (S)-1,2,9,10-tetrahydroxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline in which the four phenolic hydrogens have been replaced by methyl groups.(S)-glaucine
glycocyamineThe N-amidino derivative of glycine.guanidinoacetic acid zwitterion; guanidinoacetic acid
homoarginineAn L-lysine derivative that is the L-enantiomer of homoarginine.L-homoarginine
hydantoic acidA member of the class of ureas obtained by formal condensation of the carboxy group of carbamic acid with the amino group of glycine.N-carbamoylglycine
hydromethylthionineA member of the class of phenothiazines that is 10H-phenothiazine in which the ring hydrogens at positions 3 and 7 have been replaced by dimethylamino groups.leucomethylene blue
hypothiocyanite ionA sulfur oxoacid that is sulfenic acid in which the hydrogen attached to the sulfur has been replaced by a cyano group.hypothiocyanous acid
leukotriene b5A leukotriene composed of (6Z,8E,10E,14Z,17Z)-icosapentaenoic acid carrying (5S)- and (12R)-hydroxy substituents.leukotriene B5
lugduninA thiazolidine-containing homodetic cyclic peptide that is isolated from human nasal bacteria. Exhibits bactericidal activity against many major pathogens including methicillin-resistant Staphylococcus aureus (MRSA).lugdunin
marmesin, (r)-isomerA marmesin with R-configuration.nodakenetin
monopentyl phthalateA phthalic acid monoester obtained by formal condensation of one of the carboxy groups of phthalic acid with the hydroxy group of pentanol.monopentyl phthalate
n-acetylaspartic acidAn N-acyl-L-aspartic acid in which the acyl group is specified as acetyl.N-acetyl-L-aspartic acid
nociceptinA seventenn-membered polypeptide consisting of Phe, Gly, Gly, Phe, Thr, Gly, Ala, Arg, Lys, Ser, Ala, Arg, Lys, Leu, Ala, Asn and Gln residue joined in sequence.nociceptin
prosomatostatinA heterodetic cyclic peptide consisting of somatostatin in which the amino terminus has been acylated by the fourteen membered peptide Ser-Ala-Asn-Ser-Asn-Pro-Ala-Met-Ala-Pro-Arg-Glu-Arg-Lys.somatostatin-28
resolvin d2A member of the class of resolvins that is (4Z,8E,10Z,12E,14E,19Z)-docosahexaenoic acid carrying three hydroxy substituents at positions 7, 16 and 17 (the 7S,16R,17S-stereoisomer).resolvin D2
resolvin e2A member of the class of resolvins that is (6E,8Z,11Z,14Z,16E)-icosapentaenoic acid carrying two hydroxy substituents at positions 5 and 18 (the 5S,18R stereoisomer).resolvin E2
riddelliine n-oxideA pyrrolizine alkaloid that is 13,19-didehydrosenecionane bearing two additional hydroxy substituents at positions 12 and 18, two additional oxo groups at positions 11 and 16 and an N-oxido substituent.riddelliine N-oxide
s-adenosyl-3-methylthiopropylamineThe S-adenosyl derivative of methioninamine. It acts as the aminopropyl donor in the biosynthesis of the polyamines, spermidine and spermine.S-adenosylmethioninamine
s-benzyl-n-acetyl-l-cysteineThe S-benzyl derivative of N-acetyl-L-cysteine.N-acetyl-S-benzyl-L-cysteine

Research

Studies (17,257)

TimeframeStudies, Drugs with This Role(%)All Drugs %
pre-19905,423 (31.42)18.7374
1990's4,941 (28.63)18.2507
2000's3,714 (21.52)29.6817
2010's2,709 (15.70)24.3611
2020's470 (2.72)2.80

Study Types

Publication TypeStudies, Drugs with this Role (%)All Drugs (%)
Trials411 (2.25%)5.53%
Reviews1,060 (5.79%)6.00%
Case Studies364 (1.99%)4.05%
Observational28 (0.15%)0.25%
Other16,437 (89.82%)84.16%

Protein Targets (135)

Potency Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1Homo sapiens (human)Potency39.810711
67.9K proteinVaccinia virusPotency0.316211
acid sphingomyelinaseHomo sapiens (human)Potency31.622811
aldehyde dehydrogenase 1 family, member A1Homo sapiens (human)Potency31.622811
Alpha-synucleinHomo sapiens (human)Potency35.481311
apical membrane antigen 1, AMA1Plasmodium falciparum 3D7Potency12.589311
AR proteinHomo sapiens (human)Potency43.972246
aryl hydrocarbon receptorHomo sapiens (human)Potency62.037122
ATAD5 protein, partialHomo sapiens (human)Potency19.468422
Ataxin-2Homo sapiens (human)Potency65.139312
ATPase family AAA domain-containing protein 5Homo sapiens (human)Potency65.139312
BRCA1Homo sapiens (human)Potency7.943311
Chain A, 2-oxoglutarate OxygenaseHomo sapiens (human)Potency28.370812
Chain A, CruzipainTrypanosoma cruziPotency25.118911
Chain A, JmjC domain-containing histone demethylation protein 3AHomo sapiens (human)Potency25.118911
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASEHomo sapiens (human)Potency15.372213
chromobox protein homolog 1Homo sapiens (human)Potency68.183913
cytochrome P450 3A4 isoform 1Homo sapiens (human)Potency39.810722
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_aHomo sapiens (human)Potency5.492611
DNA polymerase eta isoform 1Homo sapiens (human)Potency8.912511
DNA polymerase iota isoform a (long)Homo sapiens (human)Potency53.808312
DNA polymerase kappa isoform 1Homo sapiens (human)Potency67.294612
estrogen nuclear receptor alphaHomo sapiens (human)Potency52.421769
estrogen receptor 2 (ER beta)Homo sapiens (human)Potency17.297024
flap endonuclease 1Homo sapiens (human)Potency64.467912
GABA theta subunitRattus norvegicus (Norway rat)Potency39.810711
Gamma-aminobutyric acid receptor subunit alpha-1Rattus norvegicus (Norway rat)Potency39.810711
Gamma-aminobutyric acid receptor subunit alpha-2Rattus norvegicus (Norway rat)Potency39.810711
Gamma-aminobutyric acid receptor subunit alpha-3Rattus norvegicus (Norway rat)Potency39.810711
Gamma-aminobutyric acid receptor subunit alpha-4Rattus norvegicus (Norway rat)Potency39.810711
Gamma-aminobutyric acid receptor subunit alpha-5Rattus norvegicus (Norway rat)Potency39.810711
Gamma-aminobutyric acid receptor subunit alpha-6Rattus norvegicus (Norway rat)Potency39.810711
Gamma-aminobutyric acid receptor subunit beta-1Rattus norvegicus (Norway rat)Potency39.810711
Gamma-aminobutyric acid receptor subunit beta-2Rattus norvegicus (Norway rat)Potency39.810711
Gamma-aminobutyric acid receptor subunit beta-3Rattus norvegicus (Norway rat)Potency39.810711
Gamma-aminobutyric acid receptor subunit deltaRattus norvegicus (Norway rat)Potency39.810711
Gamma-aminobutyric acid receptor subunit epsilonRattus norvegicus (Norway rat)Potency39.810711
Gamma-aminobutyric acid receptor subunit gamma-1Rattus norvegicus (Norway rat)Potency39.810711
Gamma-aminobutyric acid receptor subunit gamma-2Rattus norvegicus (Norway rat)Potency39.810711
Gamma-aminobutyric acid receptor subunit gamma-3Rattus norvegicus (Norway rat)Potency39.810711
Gamma-aminobutyric acid receptor subunit piRattus norvegicus (Norway rat)Potency39.810711
gemininHomo sapiens (human)Potency13.654226
GLI family zinc finger 3Homo sapiens (human)Potency59.247624
glp-1 receptor, partialHomo sapiens (human)Potency11.220212
GLS proteinHomo sapiens (human)Potency10.000011
glucocerebrosidaseHomo sapiens (human)Potency17.782811
Glycoprotein hormones alpha chainHomo sapiens (human)Potency1.122011
Guanine nucleotide-binding protein GHomo sapiens (human)Potency24.186413
Histone H2A.xCricetulus griseus (Chinese hamster)Potency86.312412
lamin isoform A-delta10Homo sapiens (human)Potency22.387211
LuciferasePhotinus pyralis (common eastern firefly)Potency30.919123
muscarinic acetylcholine receptor M1Rattus norvegicus (Norway rat)Potency28.183811
muscleblind-like protein 1 isoform 1Homo sapiens (human)Potency19.952611
NFKB1 protein, partialHomo sapiens (human)Potency0.003522
nonstructural protein 1Influenza A virus (A/WSN/1933(H1N1))Potency9.137013
NPC intracellular cholesterol transporter 1 precursorHomo sapiens (human)Potency2.511911
nuclear factor erythroid 2-related factor 2 isoform 1Homo sapiens (human)Potency52.105334
nuclear factor erythroid 2-related factor 2 isoform 2Homo sapiens (human)Potency8.587012
nuclear receptor subfamily 1, group I, member 3Homo sapiens (human)Potency35.318036
P53Homo sapiens (human)Potency7.079511
parathyroid hormone/parathyroid hormone-related peptide receptor precursorHomo sapiens (human)Potency119.047012
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1Homo sapiens (human)Potency50.118711
peroxisome proliferator activated receptor gammaHomo sapiens (human)Potency38.645512
peroxisome proliferator-activated receptor deltaHomo sapiens (human)Potency31.021222
phosphoglycerate kinaseTrypanosoma brucei brucei TREU927Potency9.962122
pregnane X nuclear receptorHomo sapiens (human)Potency42.782012
Rap guanine nucleotide exchange factor 4Homo sapiens (human)Potency29.526212
regulator of G-protein signaling 4Homo sapiens (human)Potency44.668411
retinoic acid nuclear receptor alpha variant 1Homo sapiens (human)Potency58.331436
retinoid X nuclear receptor alphaHomo sapiens (human)Potency57.060522
Smad3Homo sapiens (human)Potency35.481311
TAR DNA-binding protein 43Homo sapiens (human)Potency27.745113
TDP1 proteinHomo sapiens (human)Potency24.284624
thioredoxin reductaseRattus norvegicus (Norway rat)Potency79.432812
thyroid hormone receptor beta isoform 2Rattus norvegicus (Norway rat)Potency68.868824
thyroid hormone receptor beta isoform aHomo sapiens (human)Potency63.095711
thyroid stimulating hormone receptorHomo sapiens (human)Potency39.681534
transcriptional regulator ERG isoform 3Homo sapiens (human)Potency19.091912
USP1 protein, partialHomo sapiens (human)Potency11.220211
WRNHomo sapiens (human)Potency28.183811

Inhibition Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
5-hydroxytryptamine receptor 1AHomo sapiens (human)Ki0.171011
5-hydroxytryptamine receptor 2AHomo sapiens (human)Ki0.966022
5-hydroxytryptamine receptor 2BHomo sapiens (human)Ki0.119011
5-hydroxytryptamine receptor 2CHomo sapiens (human)Ki0.328011
5-hydroxytryptamine receptor 7Homo sapiens (human)Ki0.043011
Alkaline phosphatase, tissue-nonspecific isozymeHomo sapiens (human)IC505.000011
Autoinducer 2-binding periplasmic protein LuxPVibrio harveyiIC504.000011
Calcium release-activated calcium channel protein 1Homo sapiens (human)IC50500.000022
Chain A, AcetylcholinesteraseTetronarce californica (Pacific electric ray)Ki0.033111
Chain A, RNA-directed RNA polymerase NS5Dengue virus 2 16681-PDK53IC5057.660011
Cytochrome P450 1A1Homo sapiens (human)Ki149.000011
Cytochrome P450 1B1Homo sapiens (human)Ki149.000011
DRattus norvegicus (Norway rat)Ki2.900011
D(2) dopamine receptorRattus norvegicus (Norway rat)Ki2.800011
Delta-type opioid receptorMus musculus (house mouse)IC500.014257
Delta-type opioid receptorHomo sapiens (human)Ki1.32681315
Delta-type opioid receptorMus musculus (house mouse)Ki0.004633
Delta-type opioid receptorRattus norvegicus (Norway rat)Ki0.003244
GABA theta subunitRattus norvegicus (Norway rat)IC502.100011
Gamma-aminobutyric acid receptor subunit alpha-1Bos taurus (cattle)IC5022.000011
Gamma-aminobutyric acid receptor subunit alpha-1Rattus norvegicus (Norway rat)IC502.100011
Gamma-aminobutyric acid receptor subunit alpha-2Bos taurus (cattle)IC5022.000011
Gamma-aminobutyric acid receptor subunit alpha-2Rattus norvegicus (Norway rat)IC502.100011
Gamma-aminobutyric acid receptor subunit alpha-3Bos taurus (cattle)IC5022.000011
Gamma-aminobutyric acid receptor subunit alpha-3Rattus norvegicus (Norway rat)IC502.100011
Gamma-aminobutyric acid receptor subunit alpha-4Bos taurus (cattle)IC5022.000011
Gamma-aminobutyric acid receptor subunit alpha-4Rattus norvegicus (Norway rat)IC502.100011
Gamma-aminobutyric acid receptor subunit alpha-5Rattus norvegicus (Norway rat)IC502.100011
Gamma-aminobutyric acid receptor subunit alpha-6Rattus norvegicus (Norway rat)IC502.100011
Gamma-aminobutyric acid receptor subunit beta-1Bos taurus (cattle)IC5022.000011
Gamma-aminobutyric acid receptor subunit beta-1Rattus norvegicus (Norway rat)IC502.100011
Gamma-aminobutyric acid receptor subunit beta-2Rattus norvegicus (Norway rat)IC502.100011
Gamma-aminobutyric acid receptor subunit beta-3Rattus norvegicus (Norway rat)IC502.100011
Gamma-aminobutyric acid receptor subunit deltaRattus norvegicus (Norway rat)IC502.100011
Gamma-aminobutyric acid receptor subunit epsilonRattus norvegicus (Norway rat)IC502.100011
Gamma-aminobutyric acid receptor subunit gamma-1Rattus norvegicus (Norway rat)IC502.100011
Gamma-aminobutyric acid receptor subunit gamma-2Bos taurus (cattle)IC5022.000011
Gamma-aminobutyric acid receptor subunit gamma-2Rattus norvegicus (Norway rat)IC502.100011
Gamma-aminobutyric acid receptor subunit gamma-3Rattus norvegicus (Norway rat)IC502.100011
Gamma-aminobutyric acid receptor subunit piRattus norvegicus (Norway rat)IC502.100011
Intestinal-type alkaline phosphataseHomo sapiens (human)IC505.000011
Kappa-type opioid receptorMus musculus (house mouse)IC500.041722
Kappa-type opioid receptorCavia porcellus (domestic guinea pig)Ki10.000012
Kappa-type opioid receptorHomo sapiens (human)Ki2.378177
Kappa-type opioid receptorRattus norvegicus (Norway rat)Ki10.000012
Mu-type opioid receptorCavia porcellus (domestic guinea pig)IC500.246011
Mu-type opioid receptorHomo sapiens (human)IC509.500011
Mu-type opioid receptorMus musculus (house mouse)IC500.030834
Mu-type opioid receptorCavia porcellus (domestic guinea pig)Ki0.380011
Mu-type opioid receptorDanio rerio (zebrafish)Ki1.317011
Mu-type opioid receptorHomo sapiens (human)Ki1.177389
Mu-type opioid receptorRattus norvegicus (Norway rat)Ki0.014333
Nociceptin receptorHomo sapiens (human)IC500.00101011
Nociceptin receptorRattus norvegicus (Norway rat)IC500.000659
Nociceptin receptorHomo sapiens (human)Ki0.00021515
Opioid receptor homologueDanio rerio (zebrafish)Ki0.073011
Opioid receptor, delta 1b Danio rerio (zebrafish)Ki0.175011
Phospholipase A-2-activating proteinHomo sapiens (human)IC505.000011
Polyphenol oxidase 1Agaricus bisporusIC5010.500011
Polyunsaturated fatty acid lipoxygenase ALOX12Homo sapiens (human)IC50100.000011
Polyunsaturated fatty acid lipoxygenase ALOX15Homo sapiens (human)IC5055.000011
Protein orai-2Homo sapiens (human)IC50500.000022
Protein orai-3Homo sapiens (human)IC50500.000022
Proton-coupled amino acid transporter 1Homo sapiens (human)Ki1,500.000011
Solute carrier family 22 member 20Mus musculus (house mouse)Ki27,542.300011
Solute carrier family 22 member 6Mus musculus (house mouse)Ki837.254733
Transient receptor potential cation channel subfamily V member 2Rattus norvegicus (Norway rat)IC503.885022

Activation Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
Delta-type opioid receptorHomo sapiens (human)EC500.024678
Delta-type opioid receptorMus musculus (house mouse)EC500.068622
G-protein coupled bile acid receptor 1Homo sapiens (human)EC502.620011
Kappa-type opioid receptorHomo sapiens (human)EC500.079644
Kappa-type opioid receptorMus musculus (house mouse)EC500.063111
Mu-type opioid receptorHomo sapiens (human)EC500.589556
Mu-type opioid receptorMus musculus (house mouse)EC500.063111
Nociceptin receptorHomo sapiens (human)EC500.00691718
Nociceptin receptorMus musculus (house mouse)EC500.006146
Nociceptin receptorRattus norvegicus (Norway rat)EC500.016069
Nociceptin receptorHomo sapiens (human)Kd0.000122
Nociceptin receptorRattus norvegicus (Norway rat)Kd0.000455
Proenkephalin-BHomo sapiens (human)Kd0.007111
Somatostatin receptor type 2Homo sapiens (human)EC500.002311
Translocator proteinRattus norvegicus (Norway rat)EC500.001511

Other Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
bioAMycobacterium tuberculosis UT205AC500.389011
Delta-type opioid receptorMus musculus (house mouse)Ke0.005911
Nociceptin receptorHomo sapiens (human)Kb0.002611
Sulfotransferase 1A1Homo sapiens (human)Km19.300011