Any mammalian metabolite produced during a metabolic reaction in rat (Rattus norvegicus).
Member | Definition | Class |
1-methylhypoxanthine | A methylhypoxanthine that is hypoxanthine with the methyl group at position 1. | 1-methylhypoxanthine |
1,2,3,4-tetrahydro-beta-carboline-3-carboxylic acid | A member of the class of beta-carbolines that is 1,2,3,4-tetrahydro-beta-carboline substituted at position 3 by a carboxy group. | 1,2,3,4-tetrahydro-beta-carboline-3-carboxylic acid |
2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine | An imidazopyridine that is 1H--imidazo[4,5-b]pyridine which is substituted at positions 1, 2, and 6 by methyl, hydoxyamino, and phenyl groups, respectively. The active metabolite of the dietary carcinogen PhIP. | N-hydroxy-PhIP |
2-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline | An isoquinolinol that is norsalsolinol substituted by a methyl group at position 2. It is present in normal human brain and also identified in the cerebrospinal fluid of patients with Parkinson's disease. | N-methylnorsalsolinol |
2-nonanol | A secondary alcohol that is nonane substituted by a hydroxy group at position 2. | nonan-2-ol |
2,3,4-trihydroxbenzophenone | A benzenetriol that is benzophenone in which one of the phenyl groups is substituted by hydroxy groups at positions 2, 3, and 4. It is a redox mediator. | 2,3,4-trihydroxbenzophenone |
3-hydroxy-4-methoxyphenethylamine | A monomethoxybenzene that is dopamine in which the hydroxy group at position 4 is replaced by a methoxy group. | 4-methoxytyramine |
4-bromophenol | A bromophenol containing only hydroxy and bromo substituents that are para to one another. | 4-bromophenol |
4-heptanone | A dialkyl ketone that is heptane in which the two methylene protons at position 4 have been replaced by an oxo group. | 4-heptanone |
4-methoxyestradiol | A 17beta-hydroxy steroid that is 17beta-estradiol in which the hydrogen at position 4 has been replaced by a methoxy group. | 4-methoxy-17beta-estradiol |
5-hydroxybenzimidazole | A member of the class of benzimidazoles that is 1H-benzimidazole carrying a single hydroxy substituent at position 5. | 5-hydroxybenzimidazole |
5-methoxyindoleacetic acid | A member of the class of indole-3-acetic acids in which the hydrogen at position 5 of indole-3-acetic acid has been replaced by a methoxy group. | 5-methoxyindole-3-acetic acid |
5,15-dihydroxy-6,8,11,13-eicosatetraenoic acid | A DiHETE that is (6E,8Z,11Z,13E)-icosatetraenoic acid in which the two hydroxy substituents are placed at the 5S- and 15S-positions. | 5(S),15(S)-DiHETE |
7-hydroxydehydroepiandrosterone | An androstanoid that is dehydroepiandrosterone carrying an additional hydroxy substituent at the 7alpha-position. | 7alpha-hydroxydehydroepiandrosterone |
8-isoprostaglandin e2 | A prostanoid that is prostaglandin E2 having inverted stereochemistry at the 8-position. | 8-epi-prostaglandin E2 |
acetaminophen mercapturate | An S-substituted N-acetyl-L-cysteine in which the S-substitutuent is specified as 5-acetamido-2-hydroxyphenyl. | S-(5-acetamido-2-hydroxyphenyl)-N-acetyl-L-cysteine |
allocholic acid | An allo-bile acid that is 5alpha-cholan-24-oic acid bearing three alpha-hydroxy substituents at position 3, 7 and 12. | allocholic acid |
angiotensin i | A nine amino acid peptide which is formed when angiotensin converting enzyme 2 (ACE2) hydrolyzes the carboxy terminal leucine from angiotensin I. It is a anti-cardiac hypertrophy agent. | angiotensin (1-9) dizwitterion; angiotensin (1-9) |
angiotensin i | A peptide zwitterion that is the dizwitterionic form of angiotensin (1-9) having both carboxy groups deprotonated and the aspartyl amino group and arginine side-chain protonated. It is the major species at pH 7.3. | angiotensin (1-9) dizwitterion; angiotensin (1-9) |
benzohydrol | A secondary alcohol that is diphenylmethane which carries a hydroxy group at position 1. | diphenylmethanol |
bradykinin, des-phe(8)-des-arg(9)- | A seven-membered oligopeptide comprising Arg, Pro, Pro, Gly, Phe, Ser, and Pro residues joined in sequence by peptide bonds. It is a metabolite of bradykinin lacking the Phe residue at position 8 and the Arg residue at position 9. | [des-Phe(8), des-Arg(9)]-bradykinin |
columbianadin | An alpha,beta-unsaturated carboxylic ester obtained by formal condensation of the carboxy group of angelic acid with the hydroxy group of 2-[(8S)-2-oxo-8,9-dihydro-2H-furo[2,3-h][1]benzopyran-8-yl]propan-2-ol. | columbianadin |
cystathionine ketimine | A 1-thia-4-azacyclohepta-3-ene-3,5-dicarboxylic acid that has R-configuration. It is cyclic sulfur-containing imino acid detected in bovine brain extracts. | cystathionine ketimine |
enkephalin, leucine | A pentapeptide comprising L-tyrosine, glycine, glycine, L-phenylalanine and L-leucine residues joined in sequence by peptide linkages. It is an endogenous opioid peptide produced in vertebrate species, including rodents, primates and humans that results from decomposition of proenkephalin or dynorphin and exhibits antinociceptive properties. | Leu-enkephalin zwitterion; Leu-enkephalin |
epietiocholanolone | A 3beta-hydroxy steroid that is 5beta-androstane substituted by a hydroxy group at position 3beta and an oxo group at position 17. It is a metabolite of testosterone. | epietiocholanolone |
erucyl amide | A primary fatty amide resulting from the formal condensation of the carboxy group of erucic acid with ammonia. It is commonly used as a slip additive in the plastic manufacturing industry. | erucamide |
glaucine | An aporphine alkaloid that is (S)-1,2,9,10-tetrahydroxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline in which the four phenolic hydrogens have been replaced by methyl groups. | (S)-glaucine |
glycocyamine | The N-amidino derivative of glycine. | guanidinoacetic acid zwitterion; guanidinoacetic acid |
homoarginine | An L-lysine derivative that is the L-enantiomer of homoarginine. | L-homoarginine |
hydantoic acid | A member of the class of ureas obtained by formal condensation of the carboxy group of carbamic acid with the amino group of glycine. | N-carbamoylglycine |
hydromethylthionine | A member of the class of phenothiazines that is 10H-phenothiazine in which the ring hydrogens at positions 3 and 7 have been replaced by dimethylamino groups. | leucomethylene blue |
hypothiocyanite ion | A sulfur oxoacid that is sulfenic acid in which the hydrogen attached to the sulfur has been replaced by a cyano group. | hypothiocyanous acid |
leukotriene b5 | A leukotriene composed of (6Z,8E,10E,14Z,17Z)-icosapentaenoic acid carrying (5S)- and (12R)-hydroxy substituents. | leukotriene B5 |
lugdunin | A thiazolidine-containing homodetic cyclic peptide that is isolated from human nasal bacteria. Exhibits bactericidal activity against many major pathogens including methicillin-resistant Staphylococcus aureus (MRSA). | lugdunin |
marmesin, (r)-isomer | A marmesin with R-configuration. | nodakenetin |
monopentyl phthalate | A phthalic acid monoester obtained by formal condensation of one of the carboxy groups of phthalic acid with the hydroxy group of pentanol. | monopentyl phthalate |
n-acetylaspartic acid | An N-acyl-L-aspartic acid in which the acyl group is specified as acetyl. | N-acetyl-L-aspartic acid |
nociceptin | A seventenn-membered polypeptide consisting of Phe, Gly, Gly, Phe, Thr, Gly, Ala, Arg, Lys, Ser, Ala, Arg, Lys, Leu, Ala, Asn and Gln residue joined in sequence. | nociceptin |
prosomatostatin | A heterodetic cyclic peptide consisting of somatostatin in which the amino terminus has been acylated by the fourteen membered peptide Ser-Ala-Asn-Ser-Asn-Pro-Ala-Met-Ala-Pro-Arg-Glu-Arg-Lys. | somatostatin-28 |
resolvin d2 | A member of the class of resolvins that is (4Z,8E,10Z,12E,14E,19Z)-docosahexaenoic acid carrying three hydroxy substituents at positions 7, 16 and 17 (the 7S,16R,17S-stereoisomer). | resolvin D2 |
resolvin e2 | A member of the class of resolvins that is (6E,8Z,11Z,14Z,16E)-icosapentaenoic acid carrying two hydroxy substituents at positions 5 and 18 (the 5S,18R stereoisomer). | resolvin E2 |
riddelliine n-oxide | A pyrrolizine alkaloid that is 13,19-didehydrosenecionane bearing two additional hydroxy substituents at positions 12 and 18, two additional oxo groups at positions 11 and 16 and an N-oxido substituent. | riddelliine N-oxide |
s-adenosyl-3-methylthiopropylamine | The S-adenosyl derivative of methioninamine. It acts as the aminopropyl donor in the biosynthesis of the polyamines, spermidine and spermine. | S-adenosylmethioninamine |
s-benzyl-n-acetyl-l-cysteine | The S-benzyl derivative of N-acetyl-L-cysteine. | N-acetyl-S-benzyl-L-cysteine |
Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1 | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
67.9K protein | Vaccinia virus | Potency | 0.3162 | 1 | 1 |
acid sphingomyelinase | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
aldehyde dehydrogenase 1 family, member A1 | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
Alpha-synuclein | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
apical membrane antigen 1, AMA1 | Plasmodium falciparum 3D7 | Potency | 12.5893 | 1 | 1 |
AR protein | Homo sapiens (human) | Potency | 43.9722 | 4 | 6 |
aryl hydrocarbon receptor | Homo sapiens (human) | Potency | 62.0371 | 2 | 2 |
ATAD5 protein, partial | Homo sapiens (human) | Potency | 19.4684 | 2 | 2 |
Ataxin-2 | Homo sapiens (human) | Potency | 65.1393 | 1 | 2 |
ATPase family AAA domain-containing protein 5 | Homo sapiens (human) | Potency | 65.1393 | 1 | 2 |
BRCA1 | Homo sapiens (human) | Potency | 7.9433 | 1 | 1 |
Chain A, 2-oxoglutarate Oxygenase | Homo sapiens (human) | Potency | 28.3708 | 1 | 2 |
Chain A, Cruzipain | Trypanosoma cruzi | Potency | 25.1189 | 1 | 1 |
Chain A, JmjC domain-containing histone demethylation protein 3A | Homo sapiens (human) | Potency | 25.1189 | 1 | 1 |
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE | Homo sapiens (human) | Potency | 15.3722 | 1 | 3 |
chromobox protein homolog 1 | Homo sapiens (human) | Potency | 68.1839 | 1 | 3 |
cytochrome P450 3A4 isoform 1 | Homo sapiens (human) | Potency | 39.8107 | 2 | 2 |
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a | Homo sapiens (human) | Potency | 5.4926 | 1 | 1 |
DNA polymerase eta isoform 1 | Homo sapiens (human) | Potency | 8.9125 | 1 | 1 |
DNA polymerase iota isoform a (long) | Homo sapiens (human) | Potency | 53.8083 | 1 | 2 |
DNA polymerase kappa isoform 1 | Homo sapiens (human) | Potency | 67.2946 | 1 | 2 |
estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 52.4217 | 6 | 9 |
estrogen receptor 2 (ER beta) | Homo sapiens (human) | Potency | 17.2970 | 2 | 4 |
flap endonuclease 1 | Homo sapiens (human) | Potency | 64.4679 | 1 | 2 |
GABA theta subunit | Rattus norvegicus (Norway rat) | Potency | 39.8107 | 1 | 1 |
Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Potency | 39.8107 | 1 | 1 |
Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Potency | 39.8107 | 1 | 1 |
Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Potency | 39.8107 | 1 | 1 |
Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Potency | 39.8107 | 1 | 1 |
Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | Potency | 39.8107 | 1 | 1 |
Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | Potency | 39.8107 | 1 | 1 |
Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | Potency | 39.8107 | 1 | 1 |
Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Potency | 39.8107 | 1 | 1 |
Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | Potency | 39.8107 | 1 | 1 |
Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | Potency | 39.8107 | 1 | 1 |
Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | Potency | 39.8107 | 1 | 1 |
Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | Potency | 39.8107 | 1 | 1 |
Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | Potency | 39.8107 | 1 | 1 |
Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | Potency | 39.8107 | 1 | 1 |
Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | Potency | 39.8107 | 1 | 1 |
geminin | Homo sapiens (human) | Potency | 13.6542 | 2 | 6 |
GLI family zinc finger 3 | Homo sapiens (human) | Potency | 59.2476 | 2 | 4 |
glp-1 receptor, partial | Homo sapiens (human) | Potency | 11.2202 | 1 | 2 |
GLS protein | Homo sapiens (human) | Potency | 10.0000 | 1 | 1 |
glucocerebrosidase | Homo sapiens (human) | Potency | 17.7828 | 1 | 1 |
Glycoprotein hormones alpha chain | Homo sapiens (human) | Potency | 1.1220 | 1 | 1 |
Guanine nucleotide-binding protein G | Homo sapiens (human) | Potency | 24.1864 | 1 | 3 |
Histone H2A.x | Cricetulus griseus (Chinese hamster) | Potency | 86.3124 | 1 | 2 |
lamin isoform A-delta10 | Homo sapiens (human) | Potency | 22.3872 | 1 | 1 |
Luciferase | Photinus pyralis (common eastern firefly) | Potency | 30.9191 | 2 | 3 |
muscarinic acetylcholine receptor M1 | Rattus norvegicus (Norway rat) | Potency | 28.1838 | 1 | 1 |
muscleblind-like protein 1 isoform 1 | Homo sapiens (human) | Potency | 19.9526 | 1 | 1 |
NFKB1 protein, partial | Homo sapiens (human) | Potency | 0.0035 | 2 | 2 |
nonstructural protein 1 | Influenza A virus (A/WSN/1933(H1N1)) | Potency | 9.1370 | 1 | 3 |
NPC intracellular cholesterol transporter 1 precursor | Homo sapiens (human) | Potency | 2.5119 | 1 | 1 |
nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 52.1053 | 3 | 4 |
nuclear factor erythroid 2-related factor 2 isoform 2 | Homo sapiens (human) | Potency | 8.5870 | 1 | 2 |
nuclear receptor subfamily 1, group I, member 3 | Homo sapiens (human) | Potency | 35.3180 | 3 | 6 |
P53 | Homo sapiens (human) | Potency | 7.0795 | 1 | 1 |
parathyroid hormone/parathyroid hormone-related peptide receptor precursor | Homo sapiens (human) | Potency | 119.0470 | 1 | 2 |
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Homo sapiens (human) | Potency | 50.1187 | 1 | 1 |
peroxisome proliferator activated receptor gamma | Homo sapiens (human) | Potency | 38.6455 | 1 | 2 |
peroxisome proliferator-activated receptor delta | Homo sapiens (human) | Potency | 31.0212 | 2 | 2 |
phosphoglycerate kinase | Trypanosoma brucei brucei TREU927 | Potency | 9.9621 | 2 | 2 |
pregnane X nuclear receptor | Homo sapiens (human) | Potency | 42.7820 | 1 | 2 |
Rap guanine nucleotide exchange factor 4 | Homo sapiens (human) | Potency | 29.5262 | 1 | 2 |
regulator of G-protein signaling 4 | Homo sapiens (human) | Potency | 44.6684 | 1 | 1 |
retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 58.3314 | 3 | 6 |
retinoid X nuclear receptor alpha | Homo sapiens (human) | Potency | 57.0605 | 2 | 2 |
Smad3 | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
TAR DNA-binding protein 43 | Homo sapiens (human) | Potency | 27.7451 | 1 | 3 |
TDP1 protein | Homo sapiens (human) | Potency | 24.2846 | 2 | 4 |
thioredoxin reductase | Rattus norvegicus (Norway rat) | Potency | 79.4328 | 1 | 2 |
thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 68.8688 | 2 | 4 |
thyroid hormone receptor beta isoform a | Homo sapiens (human) | Potency | 63.0957 | 1 | 1 |
thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 39.6815 | 3 | 4 |
transcriptional regulator ERG isoform 3 | Homo sapiens (human) | Potency | 19.0919 | 1 | 2 |
USP1 protein, partial | Homo sapiens (human) | Potency | 11.2202 | 1 | 1 |
WRN | Homo sapiens (human) | Potency | 28.1838 | 1 | 1 |