Frostbite

Synonym
Frostbite

Excerpt	Reference
"Frostbite is characterized by acute tissue injury induced by freezing and thawing."	( Bulkley, GB; Im, MJ; Jesudass, R; Manson, PN; Marzella, L; Narayan, KK, 1991)
"If frostbite is to be treated successfully, direct and indirect effects of injury must be understood."	( Heggers, JP; McCauley, RL; Robson, MC, 1990)
"Frostbite is rare in Denmark and is often associated with psychiatric conditions or drug- and alcohol abuse."	( Alsbjørn, BF; Bonde, C; El-Charnoubi, WG, 2011)
"Frostbite is most likely to happen in combination with accidents, intoxications or psychiatric emergencies and typically affects smaller, more exposed areas of the body, such as fingers, toes, nose, ears, cheeks and chin."	( Durrer, B, 2015)
"Frostbite is a common injury in high altitude medicine."	( Besa, P; Cauchy, E; Irarrázaval, S; Pandey, P; Vergara, J, 2018)
"Frostbite is a localized cold-thermal injury resulting from prolonged exposure of flesh to freezing and near freezing temperatures."	( Brown, RK; Manganaro, MS; Millet, JD; Viglianti, BL; Wale, DJ; Wong, KK, 2019)
"Frostbite is thought to result from initial vasoconstriction, ischemia, intracellular ice crystal formation, and inflammation caused by reperfusion injury."	( Barksdale, AN; Li, YL; Muelleman, RL; Tu, H; Wadman, MC; Zhang, D, 2020)
"Frostbite is a thermal injury caused when tissue is exposed to sub-zero temperatures (in degrees Celsius) long enough for ice crystals to form in the affected tissue."	( Davis, C; Lorentzen, AK; Penninga, L, 2020)
"Frostbites are cold tissue damages frequently observed at high altitudes and under extremely cold conditions."	( Li, JN; Li, W; Liu, TJ; Yu, X; Zhang, K; Zhang, N, 2022)
"Frostbite is a freezing injury from direct contact with cold air or surfaces."	( Jacobsen, B; Schimelpfenig, SS, 2022)

Excerpt	Reference
"Severe frostbite affecting multiple digits, as well as dehydration and a depressed attitude, were diagnosed."	( Mans, C; Martel-Arquette, A; Sladky, K, 2016)

Excerpt	Reference
"Our algorithm for treatment of severe frostbite now includes use of i."	( Peltier, GL; Twomey, JA; Zera, RT, 2005)
"Early identification and proper treatment of frostbite is critical in saving digits and limbs."	( DelaCruz, E; Jensen, HL; Johnson, AR; Peltier, G, 2011)
"tPA and anticoagulation for treatment of severe frostbite have been reported suggesting differences in imaging techniques, route of tPA administration and management of patients after tPA infusion."	( Bailey, JK; Coffey, RA; Jones, LM; Natwa, MP, 2017)
"Of the 17, one referred to pre-hospital treatment of frostbite at K2 base camp; however, this was utilising tPA."	( Lowe, J; Warner, M, 2023)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	260 (58.96)	23.3326
1990's	55 (12.47)	12.5806
2000's	53 (12.02)	18.1394
2010's	49 (11.11)	28.8240
2020's	24 (5.44)	9.53

Drug	Relationship Strength	Studies	Trials
allantoin	low	1	0
ammonium hydroxide	low	1	0
quinacrine	low	2	0
chlorine	low	3	0
coumarin	low	1	0
salicylic acid	low	2	0
creatine	low	1	0
dimethyl sulfoxide	low	2	0
glycerol	low	1	0
dalteparin	low	2	0
histamine	low	5	0
iodine	low	2	0
inositol	low	3	0
niacinamide	low	1	0
niacin	low	2	0
nitrous oxide	low	8	0
sulfur dioxide	low	1	0
urea	low	1	0
acetazolamide	low	1	0
altretamine	low	1	0
theophylline	low	2	0
amitriptyline	low	1	0
aspirin	medium	9	1
bencyclane	low	1	0
buflomedil	medium	3	1
bupivacaine	low	6	0
busulfan	low	1	0
caffeine	low	1	0
carbamazepine	low	1	0
chloroquine	low	1	0
chlorpromazine	low	2	0
ciprofloxacin	low	1	0
cyclandelate	low	1	0
deferoxamine	low	1	0
diazepam	low	1	0
diphenhydramine	low	1	0
dipyridamole	low	1	0
fentanyl	low	1	0
guanethidine	low	2	0
hexachlorophene	low	2	0
hexamethonium	low	1	0
hydroxychloroquine	low	1	0
ibuprofen	low	3	0
lidocaine	low	1	0
indomethacin	low	2	0
isoxsuprine	low	2	0
ketanserin	low	1	0
khellin	low	1	0
meprobamate	low	1	0
methoxsalen	low	1	0
nifedipine	medium	2	2
nitroglycerin	low	3	0
oxybutynin	low	1	0
oxyphenbutazone	low	2	0
papaverine	low	2	0
pentoxifylline	low	7	0
phenindione	low	2	0
phenoxybenzamine	low	5	0
4-aminobenzoic acid	low	1	0
procaine	low	18	0
pyridinolcarbamate	low	1	0
4-methylglutamic acid	low	1	0
tetraethylammonium	low	1	0
thioridazine	low	1	0
tolazoline	low	6	0
trifluoperazine	low	1	0
prednisolone	low	2	0
reserpine	low	8	0
phentolamine	low	1	0
hydroxyproline	low	1	0
metaraminol	low	1	0
pilocarpine	low	1	0
alanine	low	1	0
chloramphenicol	low	3	0
aspartic acid	low	1	0
cloxacillin	low	1	0
leucine	low	1	0
aniline	low	1	0
chloroform	low	2	0
fluocinolone acetonide	low	3	0
histidine	low	1	0
methandrostenolone	low	1	0
propane	low	8	0
ethyl chloride	low	3	0
vinyl chloride	low	1	0
1,1-difluoroethane	low	3	0
dichlorodifluoromethane	low	1	0
triamcinolone acetonide	low	1	0
phencyclidine	low	1	0
isosorbide dinitrate	low	1	0
n-vinyl-2-pyrrolidinone	low	1	0
butane	low	2	0
ergotamine	low	1	0
phenformin	low	1	0
propylene	low	1	0
dimethyl ether	low	1	0
framycetin	low	1	0
yohimbine	low	2	0
thiazoles	low	1	0
ephedrine	low	1	0
bromochlorodifluoromethane	low	1	0
betamethasone	low	2	0
malondialdehyde	low	1	0
norflurane	low	1	0
ethylestrenol	low	1	0
d-alpha tocopherol	low	2	0
fluorescein	low	2	0
iodinated glycerol	low	1	0
technetium	low	12	0
titanium	low	1	0
argon	low	1	0
helium	low	1	0
xenon	low	3	0
magnesium sulfate	low	1	0
silver nitrate	low	1	0
trolamine salicylate	low	10	0
ammonium chloride	low	1	0
technetium 99m	low	1	0
triamcinolone	low	1	0
4-methoxyamphetamine	low	2	0
8-bromo cyclic adenosine monophosphate	low	1	0
alkenes	low	1	0
ng-nitroarginine methyl ester	low	1	0
enkephalin, methionine	low	2	0
fomesafen	low	1	0
itraconazole	low	1	0
fura-2	low	1	0
adenosine	low	1	0
atrinositol	low	1	0
enrofloxacin	low	1	0
nicotine	low	2	0
fibrinogen	low	1	0
8-chloro-cyclic adenosine monophosphate	low	1	0
leucinocaine mesylate	low	1	0
p-methoxy-n-methylphenethylamine	low	1	0
thromboxanes	low	2	0
technetium tc 99m hydroxymethylene diphosphonate	medium	5	1
butyroxan	low	1	0
impletol	low	1	0
atropine	low	1	0
ropivacaine	low	2	0
cortisone	low	3	0
glycogen	low	1	0
fibrin	low	1	0
bradykinin	low	3	0
raffinose	low	1	0
inositol 3-phosphate	low	3	0
cocaine	low	8	0
diethylstilbestrol	low	2	0
bromochloroacetic acid	low	2	0
glycosides	low	1	0
pyrophosphate	low	5	0
sulindac	low	1	0
D-fructopyranose	medium	1	1
quinine	low	1	0
thymic factor, circulating	low	1	0
bilirubin	low	1	0
vitamin k semiquinone radical	low	3	0
thromboxane a2	low	2	0
alprostadil	low	1	0
vitamin d 2	low	1	0
rutin	low	7	0
6-ketoprostaglandin f1 alpha	low	3	0
gossypin	low	1	0
thromboxane b2	low	3	0
phenylephrine hydrochloride	low	2	0
17-(dimethylaminoethylamino)-17-demethoxygeldanamycin	low	1	0
morphine	low	1	0
iloprost	medium	17	1
arsenic	low	1	0
nitrofurazone	low	1	0
tetrodotoxin	low	1	0
selenium	low	2	0
technetium tc 99m stannous pyrophosphate	low	1	0
limaprost	low	1	0
technetium tc 99m pyrophosphate	low	5	0
nitrofurantoin	low	1	0
chlorhexidine	low	2	0
indocyanine green	low	2	0
acid phosphatase	low	1	0
beta-endorphin	low	1	0
technetium tc 99m sestamibi	low	3	0
sodium pertechnetate tc 99m	low	3	0
cardiovascular agents	low	5	0
piperidines	low	2	0
ascorbic acid	low	5	0
tetracycline	low	2	0
oxytetracycline, anhydrous	low	1	0
dicumarol	low	1	0
mobic	low	1	0
warfarin	low	2	0
ethyl biscoumacetate	low	1	0
transforming growth factor beta	low	1	0
agar	low	1	0
technetium tc 99m medronate	medium	7	1
allopurinol	low	2	0
trypan blue	low	1	0
defibrotide	low	1	0

Protein Targets (1,428)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Gamma-aminobutyric acid receptor subunit pi	25	5	2	32
Lysine-specific demethylase 6B	0	1	0	1
Lysine-specific demethylase 4B	0	1	0	1
Heat shock protein HSP 90-alpha	0	3	3	6
Heat shock protein HSP 90-beta	0	1	2	3
Cholesteryl ester transfer protein	0	1	1	2
Gamma-aminobutyric acid receptor subunit beta-1	25	5	2	32
Gamma-aminobutyric acid receptor subunit delta	25	5	2	32
Gamma-aminobutyric acid receptor subunit gamma-2	25	5	2	32
5-hydroxytryptamine receptor 1A	0	16	2	18
Gamma-aminobutyric acid receptor subunit alpha-5	25	5	2	32
Gamma-aminobutyric acid receptor subunit alpha-3	25	5	2	32
Gamma-aminobutyric acid receptor subunit gamma-1	25	5	2	32
Gamma-aminobutyric acid receptor subunit alpha-2	25	5	2	32
Gamma-aminobutyric acid receptor subunit alpha-4	25	5	2	32
Gamma-aminobutyric acid receptor subunit gamma-3	25	5	2	32
Lysine-specific demethylase 5A	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	25	5	2	32
Endoplasmin	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-1	25	6	2	33
Gamma-aminobutyric acid receptor subunit beta-3	25	5	2	32
Gamma-aminobutyric acid receptor subunit beta-2	25	5	2	32
Hypoxia-inducible factor 1-alpha	0	1	1	2
GABA theta subunit	25	5	2	32
Endothelial PAS domain-containing protein 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit epsilon	25	5	2	32
Lysine-specific demethylase 4C	0	1	0	1
Chain A, Toluene-4-monooxygenase system protein A	0	1	0	1
5-hydroxytryptamine receptor 2C	0	10	3	13
5-hydroxytryptamine receptor 2A	0	12	3	15
5-hydroxytryptamine receptor 1B	0	13	1	14
5-hydroxytryptamine receptor 1D	0	3	1	4
5-hydroxytryptamine receptor 1F	0	3	1	4
5-hydroxytryptamine receptor 2B	0	10	3	13
5-hydroxytryptamine receptor 6	0	2	1	3
Sodium-dependent serotonin transporter	0	15	1	16
Sodium-dependent serotonin transporter	0	6	0	7
5-hydroxytryptamine receptor 7	0	4	1	5
5-hydroxytryptamine receptor 5A	0	2	1	3
5-hydroxytryptamine receptor 5B	0	2	1	3
5-hydroxytryptamine receptor 3A	0	2	1	3
5-hydroxytryptamine receptor 4	0	2	1	3
5-hydroxytryptamine receptor 3B	0	2	1	3
Solute carrier organic anion transporter family member 2A1	0	0	0	4
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	9	0	9
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	7	0	7
cAMP-specific 3',5'-cyclic phosphodiesterase 4C	0	5	0	5
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	8	0	8
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	17	0	0	17
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, Carbonic Anhydrase Ii	0	0	1	1
Chain A, Carbonic Anhydrase Ii	0	0	1	1
Chain A, Beta-lactamase	18	0	0	18
Chain A, Endochitinase	0	1	0	1
Chain A, Endochitinase	0	1	0	1
Chain A, Endochitinase	0	1	0	1
Chain A, Class Iii Chitinase Chia1	0	1	0	1
Chain A, Carbonic anhydrase 13	0	1	0	1
Chain A, Carbonic anhydrase II	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase	0	1	0	1
Chain B, Carbonic anhydrase	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Carbonic anhydrase	0	0	0	2
Carbonic anhydrase	0	2	0	2
thioredoxin reductase	31	0	0	31
GALC protein	7	0	0	7
GLI family zinc finger 3	53	0	0	53
nuclear receptor subfamily 1, group I, member 3	30	0	0	30
cytochrome P450 family 3 subfamily A polypeptide 4	42	0	0	42
glucocorticoid receptor [Homo sapiens]	47	0	0	47
retinoic acid nuclear receptor alpha variant 1	45	0	0	45
retinoid X nuclear receptor alpha	41	0	0	41
estrogen-related nuclear receptor alpha	52	0	0	52
Carbonic anhydrase	0	2	0	2
Carbonic anhydrase	0	2	0	2
arylsulfatase A	19	0	0	19
Carbonic anhydrase	0	2	0	2
euchromatic histone-lysine N-methyltransferase 2	56	0	0	56
Bloom syndrome protein isoform 1	14	0	0	14
thyroid hormone receptor beta isoform a	18	0	0	18
nuclear factor erythroid 2-related factor 2 isoform 1	50	0	0	50
geminin	44	0	0	44
peripheral myelin protein 22	24	0	0	24
survival motor neuron protein isoform d	17	0	0	17
muscleblind-like protein 1 isoform 1	12	0	0	12
ATP-binding cassette sub-family C member 3	0	37	0	37
Multidrug resistance-associated protein 4	0	37	0	38
Carbonic anhydrase	0	2	0	2
Solute carrier family 22 member 6	0	6	0	6
Carbonic anhydrase 12	0	6	1	12
Prolyl endopeptidase	0	1	0	1
Carbonic anhydrase-related protein 11	0	1	0	2
Bile salt export pump	0	64	0	64
Glycogen phosphorylase, muscle form	0	2	0	2
Renin	0	4	0	4
Carbonic anhydrase 1	0	13	1	25
Carbonic anhydrase 2	0	14	1	26
Carbonic anhydrase 2	0	2	0	2
Cytochrome P450 1A2	0	10	1	11
Carbonic anhydrase 3	0	5	1	10
Cathepsin B	0	1	0	1
Cytochrome P450 3A4	0	10	1	11
Steryl-sulfatase	0	1	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	2	0	2
Cytochrome P450 2C8	0	1	0	1
Cytochrome P450 2D6	0	12	1	13
Cytochrome P450 2A6	0	5	3	9
Cytochrome P450 2C9	0	16	1	17
Androgen receptor	0	7	0	7
Translocator protein	0	3	2	6
Cannabinoid receptor 1	0	1	0	1
Arachidonate 5-lipoxygenase-activating protein	0	1	0	1
Cytochrome P450 2B6	0	2	1	3
Carbonic anhydrase 4	0	6	1	10
Carbonic anhydrase 6	0	5	1	9
Carbonic anhydrase 5A, mitochondrial	0	2	0	2
Adenosine receptor A1	1	9	1	15
Serum paraoxonase/arylesterase 1	0	5	0	5
Dipeptidyl peptidase 4	0	1	0	2
Endochitinase	0	1	0	1
Adenosine receptor A2a	0	9	2	17
Delta-type opioid receptor	0	7	0	9
Cytochrome P450 2C19	0	8	0	8
Delta-type opioid receptor	0	7	1	9
Mu-type opioid receptor	0	8	2	13
Carbonic anhydrase 5A, mitochondrial	0	6	1	11
Carbonic anhydrase	0	4	0	6
Kappa-type opioid receptor	0	5	0	5
Carbonic anhydrase 7	0	5	1	9
Carbonic anhydrase	0	1	0	1
D(1A) dopamine receptor	3	1	0	4
Corticosteroid 11-beta-dehydrogenase isozyme 1	0	1	0	1
Carbonic anhydrase	0	2	0	5
D(2) dopamine receptor	0	11	1	13
Cholinesterase	0	2	0	2
Carbonic anhydrase	0	2	0	2
Mu-type opioid receptor	0	8	0	8
Fatty-acid amide hydrolase 1	0	3	0	3
Beta-carbonic anhydrase 1	0	2	0	2
Carbonic anhydrase 2	0	2	0	2
Glutamate receptor ionotropic, NMDA 2B	0	6	0	8
Squalene synthase	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-7	0	4	2	7
Carbonic anhydrase 9	0	6	1	12
Carbonic anhydrase	0	2	0	2
Carbonic anhydrase, alpha family	0	2	0	2
Carbonic anhydrase	0	2	0	5
Carbonic anhydrase 3	0	1	0	1
Carbonic anhydrase	0	2	0	6
Carbonic anhydrase	0	2	0	6
Carbonic anhydrase	0	2	0	2
Sigma intracellular receptor 2	0	2	0	2
Delta carbonic anhydrase	0	2	0	2
Sigma non-opioid intracellular receptor 1	0	4	1	5
Renin	0	1	0	1
Carbonic anhydrase	0	2	0	5
Endochitinase A1	0	1	0	1
Multidrug resistance-associated protein 1	0	1	0	1
Carbonic anhydrase 13	0	3	1	7
Canalicular multispecific organic anion transporter 1	0	34	0	34
Carbonic anhydrase 4	0	3	0	7
Carbonic anhydrase 15	0	5	0	8
Acidic mammalian chitinase	0	1	0	1
Carbonic anhydrase 13	0	5	0	8
Carbonic anhydrase 7	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 14	0	5	1	10
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 2, isoform A	0	1	0	1
Carbonic anhydrase 5B, mitochondrial	0	5	1	10
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	29	0	0	29
Chain A, Membrane lipoprotein tmpC	0	0	1	1
Chain A, Membrane lipoprotein tmpC	0	0	1	1
Chain A, Membrane lipoprotein tmpC	0	0	1	1
Chain A, Structure of PAE2307 in complex with adenosine	0	0	1	1
Chain B, Structure of PAE2307 in complex with adenosine	0	0	1	1
Chain A, ADENOSINE RECEPTOR A2A	0	1	0	1
Chain A, ADENOSINE RECEPTOR A2A	0	1	0	1
Chain A, tRNA (guanine-N(1)-)-methyltransferase	0	0	1	1
Chain A, Uncharacterized protein MJ0883	0	0	1	1
AR protein	62	0	0	62
signal transducer and activator of transcription 6, interleukin-4 induced	1	0	0	1
regulator of G-protein signaling 4	21	0	0	21
estrogen nuclear receptor alpha	67	0	0	67
NPYLR7B	0	0	3	3
IDH1	24	0	0	24
Histone H2A.x	21	0	0	21
glycogen synthase kinase-3 beta isoform 1	0	0	3	3
mitogen-activated protein kinase 1	17	0	0	17
flap endonuclease 1	13	0	0	13
nuclear receptor ROR-gamma isoform 1	15	0	0	15
high affinity choline transporter 1 isoform a	0	2	0	2
Sodium/nucleoside cotransporter 1	0	2	0	2
Calcium dependent protein kinase	0	1	0	1
Mitogen-activated protein kinase kinase kinase 7	0	0	1	1
Sodium/nucleoside cotransporter 2	0	2	0	2
Voltage-dependent calcium channel gamma-2 subunit	22	0	0	22
Rap guanine nucleotide exchange factor 3	8	0	0	8
Purine nucleoside phosphorylase	0	1	0	1
Epidermal growth factor receptor	0	8	0	8
Phosphoglycerate kinase 1	0	1	0	1
Adenosine deaminase	0	0	0	1
Avidin	0	0	1	1
Adenosine deaminase	0	0	0	1
Glyceraldehyde-3-phosphate dehydrogenase	0	3	0	3
Receptor tyrosine-protein kinase erbB-2	0	3	0	3
Insulin receptor	0	0	0	1
Phosphoglycerate kinase 2	0	1	0	1
Platelet-derived growth factor receptor beta	0	0	0	1
Adenosine receptor A3	0	10	2	13
Heat shock 70 kDa protein 1A	0	1	0	1
Heat shock cognate 71 kDa protein	0	0	1	1
Fibroblast growth factor receptor 1	0	0	0	1
Inosine-5'-monophosphate dehydrogenase 2	0	1	0	1
Endoplasmin	0	1	1	2
Glutamate receptor 2	22	0	0	22
Inosine-5'-monophosphate dehydrogenase 1	0	1	0	1
Fibroblast growth factor receptor 2	0	0	0	1
Fibroblast growth factor receptor 4	0	0	0	1
Fibroblast growth factor receptor 3	0	0	0	1
Streptavidin	0	0	1	1
Adenosylhomocysteinase	0	0	0	1
Adenosine receptor A3	0	3	0	3
Adenosine receptor A2a	0	10	6	19
Adenosine receptor A2b	0	3	1	7
Adenosine receptor A2b	0	4	1	7
Adenylate kinase 2, mitochondrial	0	1	0	1
Adenosine receptor A1	0	9	4	18
Adenylate kinase isoenzyme 1	0	1	0	1
Phosphatidylinositol 4-kinase alpha	0	2	0	3
Adenosine receptor A1	0	2	1	3
Adenosine kinase	0	0	0	1
Adenosine deaminase	0	0	0	1
Equilibrative nucleoside transporter 2	0	2	0	2
Phosphatidylinositol 4-kinase type 2-beta	0	2	0	3
Histone-lysine N-methyltransferase, H3 lysine-79 specific	0	1	0	1
Equilibrative nucleoside transporter 1	0	4	0	4
Phosphatidylinositol 4-kinase type 2-alpha	0	2	0	3
Solute carrier family 28 member 3	0	2	0	2
Adenosine kinase	0	1	0	2
Phosphatidylinositol 4-kinase beta	0	2	0	3
5-methylthioadenosine/S-adenosylhomocysteine deaminase	0	0	0	1
Adenosine transporter 1	0	0	0	1
Alanine racemase, biosynthetic	0	0	0	1
5-hydroxytryptamine receptor 1D	0	3	0	7
Glutamate receptor ionotropic, NMDA 1	0	6	0	8
Proton-coupled amino acid transporter 1	0	4	0	5
Adenosine deaminase	0	0	0	1
RGS12	2	0	0	2
estrogen receptor 2 (ER beta)	23	0	0	23
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	25	0	0	25
vitamin D3 receptor isoform VDRA	19	0	0	19
thyroid hormone receptor beta isoform 2	39	0	0	39
Alpha-synuclein	4	2	0	6
interleukin 8	10	0	0	10
TDP1 protein	51	0	0	51
thyroid stimulating hormone receptor	25	0	0	25
progesterone receptor	30	0	0	30
transcriptional regulator ERG isoform 3	6	0	0	6
ras-related protein Rab-9A	9	0	0	9
lamin isoform A-delta10	52	0	0	52
Polyphenol oxidase 2	0	5	1	7
Hypoxanthine-guanine phosphoribosyltransferase	0	0	0	1
Cellular tumor antigen p53	42	0	0	42
Xanthine dehydrogenase/oxidase [Includes: Xanthine dehydrogenase	0	1	0	1
Xanthine dehydrogenase/oxidase	0	4	0	4
Nuclear receptor ROR-gamma	0	1	0	1
Xanthine dehydrogenase/oxidase	0	3	1	5
Purine nucleoside phosphorylase	0	0	1	1
TAR DNA-binding protein 43	15	0	0	15
Shiga toxin subunit A	0	1	0	1
Histamine H3 receptor	0	2	0	3
peroxisome proliferator activated receptor gamma	32	0	0	32
Thromboxane-A synthase	0	6	0	6
Prostaglandin E2 receptor EP3 subtype	0	2	0	2
Prostaglandin E2 receptor EP4 subtype	0	2	1	3
Prostaglandin E2 receptor EP1 subtype	0	2	0	2
Prostacyclin receptor	0	3	2	5
Nuclear receptor subfamily 4 group A member 2	0	0	2	2
Nuclear receptor subfamily 4 group A member 2	0	0	1	1
Nuclear receptor subfamily 4 group A member 2	0	0	1	1
Prostaglandin E2 receptor EP2 subtype	0	2	1	3
Solute carrier organic anion transporter family member 2A1	0	0	0	2
Solute carrier organic anion transporter family member 2B1	0	1	0	1
Solute carrier organic anion transporter family member 3A1	0	0	0	1
Chain A, HADH2 protein	16	0	0	16
Chain B, HADH2 protein	16	0	0	16
EWS/FLI fusion protein	22	0	0	22
nonstructural protein 1	9	0	0	9
alpha-galactosidase	2	0	0	2
D(1A) dopamine receptor	14	0	0	14
fMet-Leu-Phe receptor	0	1	0	1
importin subunit beta-1 isoform 1	10	0	0	10
snurportin-1	10	0	0	10
GTP-binding nuclear protein Ran isoform 1	5	0	0	5
histone acetyltransferase KAT2A isoform 1	23	0	0	23
muscarinic acetylcholine receptor M1	18	0	0	18
CREB-binding protein	2	0	0	2
USP1 protein, partial	35	0	0	35
NFKB1 protein, partial	11	0	0	11
GLS protein	25	0	0	25
cytochrome P450 2D6	29	0	0	29
cytochrome P450 2D6 isoform 1	17	0	0	17
chromobox protein homolog 1	29	0	0	29
atrial natriuretic peptide receptor 2 precursor	6	0	0	6
serine/threonine-protein kinase mTOR isoform 1	8	0	0	8
Solute carrier family 22 member 1	0	13	0	17
Polyunsaturated fatty acid lipoxygenase ALOX15B	8	0	0	8
Voltage-dependent L-type calcium channel subunit alpha-1F	0	6	0	6
5-hydroxytryptamine receptor 4	0	20	0	20
Albumin	0	0	8	8
High affinity nerve growth factor receptor	0	1	2	3
Aldo-keto reductase family 1 member B1	0	17	0	17
Muscarinic acetylcholine receptor M2	0	21	3	29
Muscarinic acetylcholine receptor M4	0	16	1	20
Muscarinic acetylcholine receptor M1	0	13	2	18
Muscarinic acetylcholine receptor M3	0	12	2	17
Muscarinic acetylcholine receptor M4	0	12	2	17
Muscarinic acetylcholine receptor M5	0	11	2	16
Muscarinic acetylcholine receptor M5	0	17	1	21
Alpha-2A adrenergic receptor	0	21	3	25
Muscarinic acetylcholine receptor M2	0	12	2	18
Muscarinic acetylcholine receptor M1	0	19	3	27
Angiotensin-converting enzyme	0	12	0	12
D(2) dopamine receptor	0	14	0	15
Alpha-2B adrenergic receptor	0	18	2	21
Alpha-2C adrenergic receptor	0	21	1	23
Muscarinic acetylcholine receptor M3	0	18	1	22
D(1A) dopamine receptor	0	10	0	11
D(1B) dopamine receptor	0	2	0	3
UDP-glucuronosyltransferase 1A4	0	1	0	3
Sodium-dependent noradrenaline transporter	0	19	2	21
Histamine H2 receptor	0	9	2	11
Alpha-1D adrenergic receptor	0	20	1	21
5-hydroxytryptamine receptor 2A	0	19	1	22
5-hydroxytryptamine receptor 2C	0	22	0	23
Histamine H1 receptor	0	4	1	5
Histamine H1 receptor	0	13	2	15
D(3) dopamine receptor	0	15	0	16
Sodium channel protein type 1 subunit alpha	0	3	0	3
Sodium channel protein type 4 subunit alpha	0	5	0	6
UDP-glucuronosyltransferase 1A3	0	0	0	3
5-hydroxytryptamine receptor 2B	0	22	0	23
Alpha-1A adrenergic receptor	0	20	5	25
Histamine H2 receptor	16	1	1	22
5-hydroxytryptamine receptor 6	0	13	0	13
5-hydroxytryptamine receptor 7	0	7	0	8
Voltage-dependent N-type calcium channel subunit alpha-1B	0	1	0	1
Sodium channel protein type 7 subunit alpha	0	3	0	3
Voltage-dependent L-type calcium channel subunit alpha-1D	0	6	0	6
Sodium-dependent dopamine transporter	0	12	0	12
Potassium voltage-gated channel subfamily H member 2	0	27	0	28
Voltage-dependent L-type calcium channel subunit alpha-1S	0	6	0	6
Voltage-dependent L-type calcium channel subunit alpha-1C	0	6	0	7
Sodium channel protein type 5 subunit alpha	0	6	0	6
Sodium channel protein type 9 subunit alpha	0	7	0	7
Nuclear receptor subfamily 3 group C member 3	0	12	0	12
Sodium channel protein type 2 subunit alpha	0	3	0	3
Ataxin-2	22	0	0	22
Sigma non-opioid intracellular receptor 1	0	21	1	22
Sodium channel protein type 3 subunit alpha	0	4	0	4
Sodium channel protein type 11 subunit alpha	0	3	0	3
Sodium channel protein type 8 subunit alpha	0	3	0	3
Histamine H3 receptor	0	3	2	5
Sodium channel protein type 10 subunit alpha	0	3	0	3
vitamin D (1,25- dihydroxyvitamin D3) receptor	37	0	0	37
Steroid C26-monooxygenase	0	0	2	2
Cytochrome P450 130	0	0	1	1
Cytochrome P450 130	0	0	1	1
Chain A, Hyaluronidase, phage associated	0	1	0	1
acetylcholinesterase	17	0	0	17
RAR-related orphan receptor gamma	45	0	0	45
thioredoxin glutathione reductase	11	0	0	11
nuclear factor erythroid 2-related factor 2 isoform 2	12	0	0	13
lethal(3)malignant brain tumor-like protein 1 isoform I	3	0	0	3
lethal factor (plasmid)	18	0	0	18
Pancreatic alpha-amylase	0	2	0	2
Albumin	0	3	0	3
Urease	0	2	0	2
Prolyl 4-hydroxylase subunit alpha-1	0	0	0	1
Tyrosinase	0	1	0	1
Spike glycoprotein	23	2	3	28
Hyaluronate lyase	0	1	0	1
Prolyl hydroxylase EGLN2	0	0	0	1
Egl nine homolog 1	0	0	0	1
Prolyl hydroxylase EGLN3	0	0	0	1
Hypoxia-inducible factor 1-alpha inhibitor	0	0	0	1
Solute carrier family 23 member 1	0	1	0	1
Chain A, Ferritin light chain	8	0	0	8
phosphopantetheinyl transferase	17	0	0	17
aldehyde dehydrogenase 1 family, member A1	32	0	0	32
cytochrome P450 2C19 precursor	12	0	0	12
Metabotropic glutamate receptor 6	0	0	1	1
Excitatory amino acid transporter 4	0	1	0	1
Glutamate transporter homolog	0	0	1	1
N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase	0	1	0	1
Excitatory amino acid transporter 1	0	1	0	1
Excitatory amino acid transporter 2	0	1	0	1
Excitatory amino acid transporter 3	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	5	0	7
Glutamate receptor ionotropic, NMDA 2C	0	5	0	8
Metabotropic glutamate receptor 1	0	0	1	1
Metabotropic glutamate receptor 2	0	0	1	1
Carbonic anhydrase-like protein, putative	0	0	0	3
Glutamate receptor ionotropic, NMDA 2D	0	5	0	7
Glutamate receptor ionotropic, NMDA 3B	0	5	0	7
Glutamate receptor ionotropic, NMDA 3A	0	5	0	7
Chain A, Phospholipase A2 isoform 3	0	0	1	1
Chain A, 2-oxoglutarate Oxygenase	19	0	0	19
GTP-binding protein (rab7)	0	0	1	1
ras protein, partial	0	0	1	1
hypothetical protein, conserved	4	0	0	4
glucocerebrosidase	5	0	0	5
peroxisome proliferator-activated receptor delta	27	0	0	27
Rac1 protein	0	0	1	1
cell division cycle 42 (GTP binding protein, 25kDa), partial	0	0	1	1
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	11	0	0	11
DNA polymerase iota isoform a (long)	21	0	0	21
DNA polymerase kappa isoform 1	17	0	0	17
Prostaglandin-H2 D-isomerase	0	2	0	2
Prostaglandin G/H synthase 1	0	3	0	4
Prostaglandin G/H synthase 2	0	3	0	4
Fatty acid-binding protein, liver	0	4	0	4
Integrin beta-3	8	1	0	9
Myeloperoxidase	0	2	0	2
Prostaglandin G/H synthase 1	0	6	0	7
Seed linoleate 13S-lipoxygenase-1	0	1	0	1
Integrin alpha-IIb	8	1	0	9
Glutathione hydrolase 1 proenzyme	0	1	0	1
Prostaglandin G/H synthase 1	0	8	0	8
Substance-P receptor	0	4	0	5
Prostaglandin G/H synthase 2	0	11	1	12
Urotensin-2 receptor	0	1	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	2	0	2
Nuclear receptor ROR-gamma	15	0	0	15
Ras-related protein Rab-2A	0	0	1	1
Prostaglandin G/H synthase 2	0	5	0	5
Rho-associated protein kinase 2	0	2	0	2
Nicotinate phosphoribosyltransferase	0	5	0	5
Solute carrier family 22 member 20	0	3	0	3
Solute carrier family 22 member 6	0	3	0	3
Sigma non-opioid intracellular receptor 1	0	4	1	5
pregnane X nuclear receptor	45	0	0	45
cystic fibrosis transmembrane conductance regulator	0	2	0	2
DNA polymerase beta	6	0	0	6
short transient receptor potential channel 6 isoform 1	0	0	1	1
Muscarinic acetylcholine receptor M1	0	0	2	4
Muscarinic acetylcholine receptor M4	0	2	1	4
Reverse transcriptase/RNaseH	0	0	0	1
Muscarinic acetylcholine receptor	0	1	2	4
thyroid stimulating hormone receptor	24	0	0	24
activating transcription factor 6	18	0	0	18
v-jun sarcoma virus 17 oncogene homolog (avian)	26	0	0	26
pregnane X receptor	7	0	0	7
farnesoid X nuclear receptor	26	0	0	26
aryl hydrocarbon receptor	26	0	0	26
nuclear receptor subfamily 1, group I, member 2	8	0	0	8
galanin receptor type 3	0	1	0	1
Glucocorticoid receptor	0	14	1	20
Glycine receptor subunit alpha-1	0	14	0	14
Glycine receptor subunit beta	0	14	0	14
Glycine receptor subunit alpha-2	0	14	0	14
Glycine receptor subunit alpha-3	0	14	0	14
ORF73	0	0	1	1
Chain A, Putative fructose-1,6-bisphosphate aldolase	9	0	0	9
Chain A, Cruzipain	6	0	0	6
Microtubule-associated protein tau	25	0	0	25
caspase-1 isoform alpha precursor	3	0	0	3
Caspase-7	5	0	0	5
Inositol monophosphatase 1	10	0	0	10
Solute carrier organic anion transporter family member 1B3	0	4	0	5
Solute carrier organic anion transporter family member 1B1	0	4	0	5
Angiotensin-converting enzyme	0	0	0	1
B2 bradykinin receptor	0	1	0	1
B2 bradykinin receptor	0	2	1	5
B1 bradykinin receptor	0	1	0	1
Olfactory receptor 51E2	0	0	2	2
C-8 sterol isomerase	0	2	0	2
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase	0	2	0	2
Potassium channel subfamily K member 3	0	3	0	3
Potassium channel subfamily K member 3	0	1	0	1
Potassium channel subfamily K member 2	0	3	4	7
Potassium channel subfamily K member 9	0	1	0	1
Chain A, JmjC domain-containing histone demethylation protein 3A	13	0	0	13
15-lipoxygenase, partial	8	0	0	8
apical membrane antigen 1, AMA1	5	0	0	5
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	18	0	0	18
ubiquitin carboxyl-terminal hydrolase 2 isoform a	10	0	0	10
Matrix metalloproteinase-9	0	2	0	2
Disintegrin and metalloproteinase domain-containing protein 17	6	0	0	6
lysosomal alpha-glucosidase preproprotein	6	0	0	6
Neuronal acetylcholine receptor subunit alpha-4	5	4	2	12
Neuronal acetylcholine receptor subunit beta-2	5	4	2	12
Chain A, Glycogen Phosphorylase	0	1	0	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, Chitinase	0	1	0	1
atrial natriuretic peptide receptor 1 precursor	5	0	0	5
Cholinesterase	0	4	0	4
Glycogen phosphorylase, liver form	0	1	0	1
Glycogen phosphorylase, muscle form	0	1	0	1
Replicase polyprotein 1ab	0	6	3	9
Replicase polyprotein 1ab	0	8	4	12
Amine oxidase [flavin-containing] A	0	3	0	3
Acetylcholinesterase	0	12	0	12
Amine oxidase [flavin-containing] B	0	3	0	3
Vasopressin V2 receptor	0	0	0	2
Serine/threonine-protein kinase mTOR	0	2	0	2
Adenosine receptor A2a	0	2	0	2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	0	2	0	2
DNA-dependent protein kinase catalytic subunit	0	2	0	2
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	1	0	1
Adenylate cyclase type 1	0	0	0	2
Chitotriosidase-1	0	4	1	5
Serine-protein kinase ATM	0	1	0	1
Serine/threonine-protein kinase ATR	0	1	0	1
Adenosine receptor A2b	0	1	0	3
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	0	1	0	1
Palmitoleoyl-protein carboxylesterase NOTUM	0	1	3	4
Endochitinase B1	0	4	1	5
Phosphodiesterase	0	1	0	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	6	0	6
Guanine deaminase	0	1	0	1
ATP-dependent phosphofructokinase	16	0	0	16
Vpr	3	0	0	3
Bile salt export pump	0	8	0	8
Major prion protein	0	0	4	4
Sodium channel protein type 1 subunit alpha	0	2	0	2
Sodium channel protein type 2 subunit alpha	0	2	0	2
Sodium channel protein type 3 subunit alpha	0	2	0	2
UDP-glucuronosyltransferase 2B7	0	1	0	4
Cytochrome P450 2J2	0	8	0	8
Frizzled-8	0	0	1	1
P2X purinoceptor 4	0	1	0	1
G	24	0	0	24
heat shock protein beta-1	20	0	0	20
streptokinase A precursor	0	0	4	4
Dihydroxyacetone phosphate acyltransferase	0	0	0	2
Interferon beta	32	0	0	32
HLA class I histocompatibility antigen, B alpha chain	24	0	0	24
30S ribosomal protein S6	0	3	0	3
30S ribosomal protein S7	0	3	0	3
50S ribosomal protein L15	0	3	0	3
50S ribosomal protein L10	0	3	0	3
50S ribosomal protein L11	0	3	0	3
50S ribosomal protein L7/L12	0	3	0	3
50S ribosomal protein L19	0	3	0	3
50S ribosomal protein L1	0	3	0	3
50S ribosomal protein L20	0	3	0	3
50S ribosomal protein L27	0	3	0	3
50S ribosomal protein L28	0	3	0	3
50S ribosomal protein L29	0	3	0	3
50S ribosomal protein L31	0	3	0	3
50S ribosomal protein L31 type B	0	3	0	3
50S ribosomal protein L32	0	3	0	3
50S ribosomal protein L33	0	3	0	3
50S ribosomal protein L34	0	3	0	3
50S ribosomal protein L35	0	3	0	3
50S ribosomal protein L36	0	3	0	3
30S ribosomal protein S10	0	3	0	3
30S ribosomal protein S11	0	3	0	3
30S ribosomal protein S12	0	3	0	3
30S ribosomal protein S13	0	3	0	3
30S ribosomal protein S16	0	3	0	3
30S ribosomal protein S18	0	3	0	3
30S ribosomal protein S19	0	3	0	3
30S ribosomal protein S20	0	3	0	3
30S ribosomal protein S2	0	3	0	3
30S ribosomal protein S3	0	3	0	3
30S ribosomal protein S4	0	3	0	3
30S ribosomal protein S5	0	3	0	3
30S ribosomal protein S8	0	3	0	3
30S ribosomal protein S9	0	3	0	3
50S ribosomal protein L13	0	3	0	3
50S ribosomal protein L14	0	3	0	3
50S ribosomal protein L16	0	3	0	3
50S ribosomal protein L23	0	3	0	3
30S ribosomal protein S15	0	3	0	3
50S ribosomal protein L17	0	3	0	3
50S ribosomal protein L21	0	3	0	3
50S ribosomal protein L30	0	3	0	3
50S ribosomal protein L6	0	3	0	3
30S ribosomal protein S14	0	3	0	3
30S ribosomal protein S17	0	3	0	3
30S ribosomal protein S1	0	3	0	3
50S ribosomal protein L18	0	3	0	3
50S ribosomal protein L2	0	3	0	3
50S ribosomal protein L3	0	3	0	3
50S ribosomal protein L24	0	3	0	3
50S ribosomal protein L4	0	3	0	3
50S ribosomal protein L22	0	3	0	3
50S ribosomal protein L5	0	3	0	3
30S ribosomal protein S21	0	3	0	3
50S ribosomal protein L25	0	3	0	3
50S ribosomal protein L36 2	0	3	0	3
Inositol hexakisphosphate kinase 1	24	0	0	24
Methionine--tRNA ligase, mitochondrial	0	0	1	1
cytochrome P450 2C9, partial	24	0	0	24
Chain A, BCL-2-RELATED PROTEIN A1	0	0	1	1
Luciferase	21	0	0	21
acid sphingomyelinase	2	0	0	2
PAX8	0	0	0	2
glp-1 receptor, partial	13	0	0	13
hypoxia-inducible factor 1 alpha subunit	20	0	0	20
SMAD family member 2	18	0	0	18
SMAD family member 3	18	0	0	18
caspase 7, apoptosis-related cysteine protease	7	0	0	7
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	16	0	0	16
PINK1	2	0	0	2
67.9K protein	14	0	0	14
Parkin	5	0	0	5
heat shock protein 90	0	0	2	2
caspase-3	7	0	0	7
calcineurin A1, putative	0	0	1	1
hepatocyte nuclear factor 4-alpha isoform 2	0	1	0	1
cellular tumor antigen p53 isoform a	9	0	0	9
cytochrome P450 2C9 precursor	11	0	0	11
perilipin-5	0	2	0	2
perilipin-1	0	2	0	2
potassium voltage-gated channel subfamily H member 2 isoform d	16	0	0	16
huntingtin isoform 2	4	0	0	4
ubiquitin-conjugating enzyme E2 N	0	1	0	1
nuclear factor NF-kappa-B p105 subunit isoform 1	3	0	0	3
protein AF-9 isoform a	0	0	0	1
melanocortin receptor 4	0	1	0	1
CAAX prenyl protease	0	0	0	1
urokinase-type plasminogen activator precursor	8	0	0	8
plasminogen precursor	8	0	0	8
bcl-2-related protein A1	0	1	0	1
urokinase plasminogen activator surface receptor precursor	8	0	0	8
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform a	0	2	0	2
cytochrome P450 3A4 isoform 1	25	0	0	25
glycogen synthase kinase-3 alpha	0	0	0	2
hexokinase HKDC1	0	1	0	1
DNA repair protein RAD52 homolog isoform a	0	0	0	2
bcl-2-like protein 11 isoform 1	0	0	1	1
Synaptojanin-2	0	1	0	1
Solute carrier family 22 member 2	0	6	0	9
Synaptojanin-1	0	1	0	1
Solute carrier family 22 member 3	0	5	0	6
Glutathione reductase, mitochondrial	0	5	0	6
72 kDa type IV collagenase	0	2	0	2
Trypanothione reductase	0	7	0	7
Peroxisomal N(1)-acetyl-spermine/spermidine oxidase	0	1	0	1
Multidrug and toxin extrusion protein 2	0	2	0	2
Rap guanine nucleotide exchange factor 4	3	0	0	3
Multidrug and toxin extrusion protein 1	0	6	0	6
ATPase family AAA domain-containing protein 5	14	0	0	14
Spermine oxidase	0	1	0	1
PPM1D protein	4	0	0	4
glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase	0	2	0	2
Spike glycoprotein	0	2	3	5
Replicase polyprotein 1ab	0	2	3	5
glucose-6-phosphate 1-dehydrogenase isoform b	0	2	0	2
Transmembrane protease serine 2	0	2	3	5
Dihydrofolate reductase	0	1	0	1
DNA ligase	0	1	0	1
Riboflavin-binding protein	0	1	2	3
Amyloid-beta precursor protein	0	6	0	6
Histidine-rich protein PFHRP-II	0	3	0	4
Procathepsin L	0	3	3	6
Replicase polyprotein 1a	0	3	3	6
Replicase polyprotein 1ab	0	2	3	5
Spike glycoprotein	0	1	0	1
Ribosyldihydronicotinamide dehydrogenase [quinone]	0	1	0	1
DNA ligase 1	0	1	0	1
Beta-secretase 1	0	3	0	3
Calcium-dependent protein kinase 1	0	0	1	1
MO15-related protein kinase Pfmrk	0	1	0	1
DNA ligase A	0	1	0	1
Sigma intracellular receptor 2	0	2	0	2
Phosphoethanolamine N-methyltransferase	0	1	0	1
Angiotensin-converting enzyme 2	0	2	3	5
Cysteine proteinase falcipain 2a	0	1	0	1
Cysteine proteinase falcipain 2a	0	1	0	1
Proteasome subunit beta type-11	0	0	0	1
ATAD5 protein, partial	16	0	0	16
Fumarate hydratase	11	0	0	11
Thrombopoietin	7	0	0	7
Smad3	11	0	0	11
NADPH oxidase 1	0	2	0	2
polyprotein	11	0	0	11
Snq2p	0	0	0	3
Adenylate cyclase type 1	0	2	0	2
Caspase-7	5	0	0	5
caspase-3	5	0	0	5
histone deacetylase 9 isoform 3	3	0	0	3
M-phase phosphoprotein 8	9	0	0	9
Proteasome subunit alpha type-7	0	0	0	1
Glutamate receptor ionotropic, NMDA 2D	0	2	0	2
Transient receptor potential cation channel subfamily V member 1	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	2	0	2
Albumin	0	5	6	12
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	0	3	0	3
Major prion protein	0	1	1	2
Tyrosine-protein kinase Fyn	0	5	0	5
ATP-dependent translocase ABCB1	0	13	1	17
5-hydroxytryptamine receptor 1A	0	3	1	4
Cys-loop ligand-gated ion channel	0	1	0	1
Calmodulin-1	0	2	2	4
Polyunsaturated fatty acid lipoxygenase ALOX15	0	4	0	4
Alpha-1B adrenergic receptor	0	18	5	23
Sphingomyelin phosphodiesterase	0	1	0	1
D	0	7	0	7
D(3) dopamine receptor	0	6	0	6
Alpha-2B adrenergic receptor	0	9	4	13
D(2) dopamine receptor	0	1	0	1
Proteasome subunit beta type-1	0	0	0	1
Substance-K receptor	0	6	0	6
D(4) dopamine receptor	0	6	0	7
Adenylate cyclase type 3	0	2	0	2
Alpha-2C adrenergic receptor	0	9	4	13
Alpha-2A adrenergic receptor	0	9	4	13
Alpha-1D adrenergic receptor	0	12	5	18
Sodium-dependent dopamine transporter	0	7	0	7
D(1B) dopamine receptor	0	5	0	5
Proteasome subunit alpha type-1	0	0	0	1
Proteasome subunit alpha type-2	0	0	0	1
Proteasome subunit alpha type-3	0	0	0	1
Proteasome subunit alpha type-4	0	0	0	1
Adenylate cyclase type 2	0	2	0	2
Adenylate cyclase type 4	0	2	0	2
Proteasome subunit beta type-8	0	0	0	1
Proteasome subunit beta type-9	0	0	0	1
Proteasome subunit alpha type-5	0	0	0	1
Proteasome subunit beta type-4	0	0	0	1
Proteasome subunit beta type-6	0	0	0	1
Proteasome subunit beta type-5	0	0	0	1
D(4) dopamine receptor	0	5	0	5
Histamine H1 receptor	0	3	3	7
Melanocortin receptor 4	0	2	0	2
Melanocortin receptor 5	0	2	0	2
Pleiotropic ABC efflux transporter of multiple drugs	0	3	0	6
5-hydroxytryptamine receptor 7	0	3	0	3
Mu-type opioid receptor	0	12	3	16
Adenylate cyclase type 8	0	2	0	2
Proteasome subunit beta type-10	0	0	0	1
Delta-type opioid receptor	0	10	1	12
Kappa-type opioid receptor	0	12	1	14
Melanocortin receptor 3	0	2	0	2
Proteasome subunit beta type-3	0	0	0	1
Proteasome subunit beta type-2	0	0	0	1
Gastrin/cholecystokinin type B receptor	0	1	0	1
Proteasome subunit alpha type-6	0	0	2	3
Calmodulin	0	1	2	3
Aldehyde oxidase 1	0	2	0	2
Adenylate cyclase type 6	0	2	0	2
Adenylate cyclase type 5	0	2	0	2
Glutamate receptor ionotropic, NMDA 1	0	3	0	3
Aldehyde oxidase	0	4	0	6
Glutamate receptor ionotropic, NMDA 2A	0	3	0	3
Glutamate receptor ionotropic, NMDA 2B	0	3	0	3
Glutamate receptor ionotropic, NMDA 2C	0	2	0	2
Adenylyl cyclase 7	0	2	0	2
Proteasome subunit alpha-type 8	0	0	0	1
Glutamate receptor ionotropic, NMDA 3A	0	2	0	2
D	0	1	0	1
Proteasome subunit beta type-7	0	0	0	1
DNA gyrase subunit B	0	1	0	1
DNA gyrase subunit A	0	1	0	1
DNA gyrase subunit B	0	1	0	2
DNA gyrase subunit A	0	1	0	3
DNA gyrase subunit B	0	1	0	3
DNA topoisomerase 4 subunit A	0	1	0	1
DNA topoisomerase 4 subunit B	0	1	0	2
DNA topoisomerase 4 subunit A	0	1	0	2
DNA topoisomerase 2-alpha	0	1	0	4
DNA gyrase subunit A	0	1	0	2
Multidrug resistance protein MdtK	0	0	1	1
DNA gyrase subunit B	0	1	0	1
DNA gyrase subunit A	0	1	0	1
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	0	0	1
DNA topoisomerase 4 subunit A	0	1	0	1
DNA topoisomerase 4 subunit B	0	1	0	1
Integrase	0	4	0	4
Beta-lactamase	0	1	0	1
Solute carrier family 22 member 8	0	1	0	1
Beta-lactamase OXA-7	0	0	0	1
Solute carrier family 15 member 1	0	1	0	1
Beta-lactamase TEM	0	1	0	1
Solute carrier family 15 member 2	0	1	0	1
Efflux transporter	0	1	0	1
Beta-lactamase	0	1	0	1
Solute carrier family 15 member 2	0	1	0	1
Metallo-b-lactamase	0	0	0	1
Beta-lactamase class B VIM-2	0	0	0	1
Chain A, CHIMERA OF IG KAPPA CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION	0	0	1	1
Chain B, CHIMERA OF IG GAMMA-1 CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION	0	0	1	1
Chain H, Fab M82G2, Heavy chain	0	0	1	1
Chain L, Fab M82G2, Light chain	0	0	1	1
Chain H, Fab M82g2, Heavy Chain	0	0	1	1
Chain L, Fab M82g2, Light Chain	0	0	1	1
Gamma-aminobutyric acid receptor subunit pi	0	3	0	3
Gamma-aminobutyric acid receptor subunit delta	0	3	0	3
Fatty acid-binding protein, heart	0	1	0	1
Muscarinic acetylcholine receptor M2	0	1	0	1
Tryptophan 5-hydroxylase 1	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-1	0	3	2	5
Gamma-aminobutyric acid receptor subunit beta-1	0	3	0	3
Gamma-aminobutyric acid receptor subunit gamma-2	0	3	1	4
Liver carboxylesterase 1	0	0	0	1
Gamma-aminobutyric acid receptor subunit beta-3	0	3	1	4
Gamma-aminobutyric acid receptor subunit alpha-5	0	3	2	5
Gamma-aminobutyric acid receptor subunit alpha-3	0	3	1	4
Lysosomal Pro-X carboxypeptidase	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-2	0	3	1	4
Gamma-aminobutyric acid receptor subunit beta-2	0	3	1	4
Gamma-aminobutyric acid receptor subunit alpha-4	0	3	0	3
Gamma-aminobutyric acid receptor subunit epsilon	0	3	0	3
Leukotriene B4 receptor 1	0	1	0	2
Gamma-aminobutyric acid receptor subunit alpha-6	0	3	0	3
Sodium-dependent dopamine transporter	0	2	0	2
Gamma-aminobutyric acid receptor subunit gamma-1	0	3	0	3
Gamma-aminobutyric acid receptor subunit gamma-3	0	3	0	3
Leukotriene B4 receptor 2	0	1	0	2
Gamma-aminobutyric acid receptor subunit theta	0	3	0	3
Transporter	0	3	1	5
Cytochrome P450 2D1	0	2	0	2
Cytochrome P450 2D26	0	3	0	3
Cytochrome P450 2D3	0	3	0	3
Kappa-type opioid receptor	0	3	1	6
Mu-type opioid receptor	0	4	1	8
Cytochrome P450 2D4	0	3	0	3
Mas-related G-protein coupled receptor member X2	0	0	2	2
endonuclease IV	3	0	0	3
dopamine D1 receptor	4	0	0	4
peripheral myelin protein 22 isoform 1	8	0	0	8
Sex hormone-binding globulin	0	0	1	1
Corticosteroid-binding globulin	0	2	0	2
Potassium voltage-gated channel subfamily A member 1	0	2	1	3
Exportin-1	0	1	0	1
NAD-dependent histone deacetylase SIR2	0	2	0	4
Aldo-keto reductase family 1 member B1	0	5	0	5
UDP-glucuronosyltransferase 1-6	0	1	0	1
Amine oxidase [flavin-containing] B	0	1	0	1
Cytochrome P450 2A5	0	1	0	2
Amine oxidase [flavin-containing] A	0	1	0	1
Acetylcholinesterase	0	1	0	1
UDP-glucuronosyltransferase 1A1	0	1	0	1
Glyceraldehyde-3-phosphate dehydrogenase, glycosomal	0	1	0	1
UDP-glucuronosyltransferase 2B10	0	1	0	1
Quinone oxidoreductase	0	0	0	1
Sorbitol dehydrogenase	0	1	0	1
Induced myeloid leukemia cell differentiation protein Mcl-1	0	2	0	2
Zn finger protein	0	1	0	1
Dihydroorotate dehydrogenase	0	2	0	2
Sodium- and chloride-dependent creatine transporter 1	0	1	0	1
Glutathione S-transferase P	0	1	0	1
Alpha-tocopherol transfer protein	0	0	1	1
Lysine-specific demethylase 4A	0	1	0	1
Guanine nucleotide-binding protein G	6	0	0	6
Methylcytosine dioxygenase TET2	0	1	0	1
Deoxyhypusine hydroxylase	0	1	0	1
Gamma-aminobutyric acid	0	1	0	1
Alpha-1-acid glycoprotein 1	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	2	0	2
Gamma-aminobutyric acid receptor subunit beta-1	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-2	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-3	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-6	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	2	0	2
Gamma-aminobutyric acid receptor subunit gamma-2	0	2	0	2
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit delta	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-3	0	1	0	1
Translocator protein	0	1	0	1
Translocator protein	0	1	0	1
Cholecystokinin receptor type A	0	1	0	1
Gastrin/cholecystokinin type B receptor	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	1	0	1
Gamma-aminobutyric acid receptor subunit pi	0	1	0	1
Sphingosine-1-phosphate lyase 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	0	1
Gamma-aminobutyric acid receptor subunit theta	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	1	0	1
NAD	0	1	0	1
NAD	0	2	0	3
Mitogen-activated protein kinase 1	0	2	0	2
ATP phosphoribosyltransferase	0	1	0	1
Proprotein convertase subtilisin/kexin type 7	0	2	0	2
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	1	0	1
G-protein coupled receptor 35	0	1	1	2
serine/threonine-protein kinase PLK1	7	0	0	7
histone-lysine N-methyltransferase 2A isoform 2 precursor	5	0	0	5
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	4	0	0	4
neuropeptide S receptor isoform A	5	0	0	5
Nuclear receptor subfamily 1 group I member 2	0	1	1	2
Estrogen receptor	0	6	1	7
Beta-1 adrenergic receptor	0	4	0	4
Vasopressin V1a receptor	0	2	0	2
Estrogen-related receptor gamma	0	0	1	1
UDP-glucose 4-epimerase	0	1	0	1
Mitogen-activated protein kinase 14	0	3	0	3
Estrogen receptor beta	0	4	1	5
Cysteinyl leukotriene receptor 1	0	2	0	2
Cereblon isoform 4	0	2	0	2
Insulin-like growth factor-binding protein 5	0	0	1	1
Choline O-acetyltransferase	0	1	0	1
Protein cereblon	0	2	0	2
Histamine N-methyltransferase	0	0	0	1
Solute carrier family 22 member 1	0	7	0	11
Calcium release-activated calcium channel protein 1	0	1	0	1
Protein orai-2	0	1	0	1
Protein orai-3	0	1	0	1
Histamine H4 receptor	0	2	2	4
Solute carrier family 22 member 2	0	6	0	8
Chain A, Breast cancer type 1 susceptibility protein	1	0	0	1
90-kda heat shock protein beta HSP90 beta, partial	0	2	0	2
DNA polymerase III, partial	1	0	0	1
isocitrate dehydrogenase 1, partial	1	0	0	1
LANA	0	0	0	1
bromodomain adjacent to zinc finger domain 2B	13	0	0	13
thyrotropin-releasing hormone receptor	5	0	0	5
serine-protein kinase ATM isoform a	1	0	0	1
guanine nucleotide-binding protein G(i) subunit alpha-1 isoform 1	1	0	0	1
eyes absent homolog 2 isoform a	4	0	0	4
heat shock protein HSP 90-alpha isoform 2	0	2	0	3
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	7	0	0	7
tumor susceptibility gene 101 protein	2	0	0	2
DNA dC->dU-editing enzyme APOBEC-3F isoform a	2	0	0	2
kelch-like ECH-associated protein 1	0	0	0	2
cGMP-dependent 3',5'-cyclic phosphodiesterase	0	4	0	4
Multidrug resistance-associated protein 5	0	1	0	1
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta	0	1	0	1
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A	0	3	0	3
cGMP-specific 3',5'-cyclic phosphodiesterase	0	3	0	3
3',5'-cyclic-AMP phosphodiesterase	0	3	0	3
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha	0	1	0	1
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	0	1	0	1
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta	0	1	0	1
Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	0	3	0	3
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	3	0	3
cGMP-inhibited 3',5'-cyclic phosphodiesterase B	0	4	0	4
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A	0	2	0	2
Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	0	4	0	4
cGMP-inhibited 3',5'-cyclic phosphodiesterase A	0	5	0	5
Exopolyphosphatase PRUNE1	0	1	0	1
Single-stranded DNA cytosine deaminase	1	0	0	1
Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 7B	0	1	0	1
Phosphodiesterase	0	2	0	2
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	0	2	0	3
Kinesin-like protein KIF11	0	1	0	1
Nucleotide-binding oligomerization domain-containing protein 2	0	1	0	1
Adenylate cyclase	0	1	0	1
Tyrosine-protein kinase Lck	0	2	0	2
ATP-dependent translocase ABCB1	0	3	0	3
Beta-2 adrenergic receptor	0	2	0	2
ATP-dependent translocase ABCB1	0	3	0	3
5-hydroxytryptamine receptor 1B	0	3	0	3
5-hydroxytryptamine receptor 5A	0	2	0	2
Chain A, ATP-DEPENDENT DNA HELICASE Q1	4	0	0	4
Genome polyprotein	0	3	1	4
chaperonin-containing TCP-1 beta subunit homolog	2	0	0	2
relaxin receptor 1 isoform 1	2	0	0	2
Flavin reductase (NADPH)	0	0	1	1
large T antigen	0	2	0	2
fibroblast growth factor 22 isoform 1 precursor	0	0	0	1
Protease	0	2	0	2
Kappa-type opioid receptor	0	3	1	5
Menin	0	0	1	1
Lecithin retinol acyltransferase	0	1	0	1
Lethal factor	0	1	0	1
Protein Rev	0	0	1	1
Aminoglycoside 3'-phosphotransferase	0	0	0	1
Tyrosyl-DNA phosphodiesterase 1	0	1	0	1
Chain B, EUKARYOTIC TRANSLATION INITIATION FACTOR 4E	0	0	1	1
Aurora kinase B	0	1	0	1
Nitric oxide synthase, brain	0	0	0	1
Nitric oxide synthase, inducible	0	1	0	2
calpain II, partial	0	1	0	1
SUMO-1	0	1	0	1
Mcl-1	0	1	0	1
Valosin-containing protein	0	2	0	2
TSHR protein	1	0	0	1
Estrogen receptor 1	0	1	0	1
envelope glycoprotein	0	1	0	1
heat shock 70kDa protein 1A	0	1	0	1
galactokinase	1	0	0	1
NPC intracellular cholesterol transporter 1 precursor	4	0	0	4
tumor necrosis factor	2	0	0	2
polyunsaturated fatty acid lipoxygenase ALOX12	3	0	0	3
neuropeptide Y receptor type 1	0	0	1	1
neuropeptide Y receptor type 2	0	0	1	1
small ubiquitin-related modifier 2 isoform b precursor	0	1	0	1
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	7	0	0	7
estrogen receptor beta isoform 1	0	3	0	3
enteropeptidase precursor	1	0	0	1
fatty acid synthase	0	1	0	1
eukaryotic translation initiation factor 4 gamma 1 isoform 4	0	2	0	2
DNA polymerase eta isoform 1	3	0	0	3
heat shock cognate 71 kDa protein isoform 1	0	1	0	1
eukaryotic translation initiation factor 4E isoform 1	0	2	0	2
4-(cytidine 5'-phospho)-2-C-methyl-D-erithritol kinase	1	0	0	1
replicative DNA helicase	0	0	0	1
recombinase A	0	0	1	1
exodeoxyribonuclease V subunit RecD	0	1	0	1
exodeoxyribonuclease V subunit RecB	0	1	0	1
exodeoxyribonuclease V subunit RecC	0	1	0	1
POsterior Segregation	0	0	2	2
heat shock cognate 71 kDa protein isoform 2	0	1	0	1
Urokinase-type plasminogen activator	0	1	0	1
Tissue-type plasminogen activator	0	1	0	1
Plasminogen activator inhibitor 1	0	1	0	1
Estrogen receptor	0	0	2	2
Urokinase-type plasminogen activator	0	1	0	1
60 kDa chaperonin	0	2	0	2
60 kDa heat shock protein, mitochondrial	0	2	0	2
Endoplasmic reticulum chaperone BiP	0	1	0	1
Macrophage migration inhibitory factor	0	6	0	6
Mitogen-activated protein kinase 3	0	1	0	1
10 kDa heat shock protein, mitochondrial	0	2	0	2
Thiosulfate sulfurtransferase	0	2	0	2
60 kDa chaperonin	0	3	0	3
Estrogen receptor beta	0	0	2	2
N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D	0	1	0	1
10 kDa chaperonin	0	3	0	3
N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D	0	1	0	1
Zinc finger protein mex-5	0	0	2	2
phosphoglycerate kinase	2	0	0	2
heat shock protein 90, putative	0	0	0	1
M1-family alanyl aminopeptidase	0	1	0	1
hypothetical protein CAALFM_CR05890CA	0	0	0	1
H3 histone acetyltransferase	0	0	0	1
BZLF2	0	1	0	1
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, Protein (female-specific Histamine Binding Protein 2)	0	0	1	1
aryl hydrocarbon receptor nuclear translocator	0	0	0	1
transforming acidic coiled-coil-containing protein 3	0	0	0	1
Plasma kallikrein	0	0	0	2
Metabotropic glutamate receptor 5	0	2	1	3
Histamine H3 receptor	0	1	0	1
Histamine N-methyltransferase	0	1	0	1
Glutaminyl-peptide cyclotransferase	0	2	0	2
Equilibrative nucleoside transporter 4	0	0	0	1
Histamine H4 receptor	0	1	2	3
Histamine H4 receptor	0	1	2	3
Histamine H4 receptor	0	1	0	1
Carboxylic ester hydrolase	0	0	0	1
Chain A, HISTIDINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Histidine-binding periplasmic protein	0	0	1	1
Large neutral amino acids transporter small subunit 1	0	2	0	2
Cyclic GMP-AMP synthase	0	2	0	2
Toll-like receptor 9	0	1	0	1
Toll-like receptor 7	0	1	0	1
Neutral amino acid transporter A	0	1	0	1
Asc-type amino acid transporter 1	0	1	0	1
Neutral amino acid transporter B(0)	0	1	0	1
Amino acid transporter	0	1	0	1
Acid-sensing ion channel 3	0	1	0	1
Solute carrier organic anion transporter family member 1A4	0	2	0	2
Dihydrofolate reductase	0	3	0	3
Fatty acid-binding protein, intestinal	0	1	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	3	0	5
Prostaglandin G/H synthase 1	0	2	0	2
Caspase-1	0	1	0	2
Prostaglandin G/H synthase 2	0	2	0	3
Aldo-keto reductase family 1 member C3	0	5	0	5
Caspase-3	0	1	0	1
Solute carrier organic anion transporter family member 1A1	0	2	0	2
Caspase-4	0	1	0	1
Caspase-5	0	1	0	1
Caspase-9	0	1	0	1
Acid-sensing ion channel 1	0	1	0	1
Prostaglandin G/H synthase 2	0	3	0	4
Solute carrier family 22 member 6	0	3	0	3
Prostaglandin G/H synthase 1	0	2	0	3
Solute carrier family 22 member 8	0	3	0	4
Dehydrogenase/reductase SDR family member 9	0	1	0	1
Prostaglandin E2 receptor EP1 subtype	0	0	1	1
Prostaglandin E2 receptor EP3 subtype	0	1	0	1
Prostaglandin E2 receptor EP2 subtype	0	0	1	1
Prostacyclin receptor	0	1	1	2
Prostaglandin D2 receptor	0	0	1	1
Chain A, membrane-associated prostaglandin E synthase-2	0	1	0	1
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	5	0	0	5
Prostaglandin E synthase	0	2	0	2
Solute carrier organic anion transporter family member 2B1	0	2	0	2
Cytochrome c oxidase subunit 2	0	1	0	1
Phospholipase A2, major isoenzyme	0	1	0	1
Interleukin-8	0	1	0	1
Androgen receptor	0	2	1	3
Aldo-keto reductase family 1 member B1	0	2	0	2
Aldo-keto reductase family 1 member C4	0	2	0	2
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Indoleamine 2,3-dioxygenase 1	0	2	0	2
Nitric oxide synthase, inducible	0	2	0	2
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Multidrug resistance-associated protein 1	0	1	0	1
Bifunctional epoxide hydrolase 2	0	2	0	2
Peroxisome proliferator-activated receptor gamma	0	0	3	3
Sodium- and chloride-dependent betaine transporter	0	1	0	1
C-X-C chemokine receptor type 3	0	1	0	1
Aldo-keto reductase family 1 member C2	0	3	0	3
Prostaglandin D2 receptor	0	2	0	2
Solute carrier organic anion transporter family member 1A3	0	1	0	1
Lactoylglutathione lyase	0	2	0	2
Aldo-keto reductase family 1 member C1	0	3	0	3
Uracil nucleotide/cysteinyl leukotriene receptor	0	1	0	1
Solute carrier family 22 member 7	0	0	0	2
Dehydrogenase/reductase SDR family member 9	0	1	0	1
P2Y purinoceptor 12	0	1	0	1
Cytosolic phospholipase A2 gamma	0	1	0	1
Prostaglandin D2 receptor 2	0	1	1	2
Chain B, Pulmonary surfactant-associated protein D	0	1	0	1
Chain A, Pulmonary surfactant-associated protein D	0	1	0	1
Sodium/myo-inositol cotransporter 2	0	1	0	1
Cytochrome P450 144	0	0	1	1
Steroid C26-monooxygenase	0	0	1	1
Synaptic vesicular amine transporter	0	4	1	5
Vesicular acetylcholine transporter	0	1	0	1
Cytochrome P450 1A1	0	2	0	2
Cytochrome P450 1B1	0	1	0	1
Chain A, AMINOPEPTIDASE	0	1	0	1
Chain A, AMINOPEPTIDASE	0	1	0	1
Chain A, Leucine Aminopeptidase	0	1	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	3	0	3
Intestinal-type alkaline phosphatase	0	2	0	2
Phospholipase A-2-activating protein	0	2	0	2
Potassium voltage-gated channel subfamily A member 5	0	2	0	2
Potassium voltage-gated channel subfamily D member 2	0	1	0	1
Potassium channel subfamily K member 18	0	1	0	1
Aldo-keto reductase family 1 member B10	0	2	0	2
Transient receptor potential cation channel subfamily A member 1	0	0	2	2
Transient receptor potential cation channel subfamily M member 2	0	1	0	1
Beta-lactamase	0	1	0	1
Myc proto-oncogene protein	0	1	0	1
Malate dehydrogenase, cytoplasmic	0	1	0	1
Peroxisome proliferator-activated receptor alpha	1	0	0	1
NACHT, LRR and PYD domains-containing protein 3	0	1	0	1
Cytochrome P450 2A13	0	3	3	6
Glucose-6-phosphate 1-dehydrogenase	0	1	0	1
6-phosphogluconate dehydrogenase, decarboxylating	0	1	0	1
Opioid receptor, delta 1b	0	1	0	1
Acetylcholinesterase	0	1	0	1
Opioid receptor homologue	0	1	0	1
Acyl-CoA desaturase 1	0	1	0	1
Histidine decarboxylase	0	0	1	1
Proteinase-activated receptor 1	0	1	1	2
Nociceptin receptor	0	1	0	1
Mu-type opioid receptor	0	1	0	1
Beta-2 adrenergic receptor	0	1	0	2
Mu-type opioid receptor	0	1	0	1
pyruvate kinase PKM isoform b	1	0	0	1
Ornithine decarboxylase	1	0	0	1
Neutrophil elastase	0	1	0	1
Nitric oxide synthase, endothelial	0	1	0	1
Nitric oxide synthase, endothelial	0	1	0	1
Nitric oxide synthase, brain	0	1	0	1
Collagenase 3	0	2	0	2
D-amino-acid oxidase	0	1	0	1
Hydroxycarboxylic acid receptor 3	0	0	1	1
Nicotinamidase	0	1	0	1
Hydroxycarboxylic acid receptor 2	0	0	1	1
Hydroxycarboxylic acid receptor 2	0	2	1	3
D-aspartate oxidase	0	1	0	1
Hydroxycarboxylic acid receptor 2	0	1	1	2
Chain A, NAD-dependent deacetylase	0	1	0	1
Poly [ADP-ribose] polymerase 2	0	1	0	1
Coagulation factor VII	0	1	0	1
Poly [ADP-ribose] polymerase 1	0	1	0	1
Tissue factor	0	1	0	1
Cytochrome P450 3A5	0	1	0	1
NAD-dependent protein deacetylase HST2	0	1	0	1
Protein mono-ADP-ribosyltransferase PARP15	0	1	0	1
NAD(+) hydrolase SARM1	0	3	0	3
NAD-dependent protein deacetylase sirtuin-2	0	1	0	1
NAD-dependent protein deacetylase sirtuin-6	0	1	0	1
NAD-dependent protein deacetylase sirtuin-1	0	1	0	1
NAD-dependent protein deacetylase sirtuin-3, mitochondrial	0	1	0	1
NAD-dependent protein deacylase sirtuin-5, mitochondrial	0	1	0	1
NAD-dependent protein deacetylase	0	1	0	1
5-hydroxytryptamine receptor 3E	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-4	0	2	1	3
5-hydroxytryptamine receptor 3B	0	1	0	1
Acetylcholine receptor subunit alpha	0	2	1	3
Acetylcholine receptor subunit alpha	0	2	1	3
Acetylcholine receptor subunit beta	0	2	1	3
Acetylcholine receptor subunit gamma	0	2	1	3
Acetylcholine receptor subunit delta	0	2	1	3
Neuronal acetylcholine receptor subunit alpha-3	0	2	2	5
Acetylcholine receptor subunit gamma	0	2	1	3
Neuronal acetylcholine receptor subunit alpha-4	0	1	0	1
Acetylcholine receptor subunit beta	0	2	1	3
Neuronal acetylcholine receptor subunit alpha-2	0	2	2	5
Neuronal acetylcholine receptor subunit beta-3	0	2	2	5
Neuronal acetylcholine receptor subunit beta-4	0	2	2	5
Neuronal acetylcholine receptor subunit beta-2	0	2	1	3
Neuronal acetylcholine receptor subunit alpha-5	0	2	2	5
Acetylcholine receptor subunit beta-like 2	0	2	0	2
Neuronal acetylcholine receptor subunit alpha-5	0	0	1	1
Neuronal acetylcholine receptor subunit beta-4	0	2	1	3
Neuronal acetylcholine receptor subunit alpha-3	0	2	1	3
Neuronal acetylcholine receptor subunit alpha-7	0	2	2	4
Neuronal acetylcholine receptor subunit alpha-6	0	2	2	5
Neuronal acetylcholine receptor subunit alpha-9	0	2	2	5
Neuronal acetylcholine receptor subunit alpha-4	0	2	1	3
5-hydroxytryptamine receptor 3A	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-7	0	2	0	2
Acetylcholine-binding protein	0	1	1	2
Acetylcholine receptor subunit epsilon	0	0	1	1
Neuronal acetylcholine receptor subunit beta-3	0	1	1	2
Acetylcholine receptor subunit delta	0	2	1	3
Neuronal acetylcholine receptor subunit alpha-2	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-6	0	1	1	2
Neuronal acetylcholine receptor subunit alpha-5	0	2	0	2
Liver carboxylesterase B-1	0	1	0	1
5-hydroxytryptamine receptor 3D	0	1	0	1
Transient receptor potential cation channel subfamily A member 1	0	0	2	2
Neuronal acetylcholine receptor subunit beta-3	0	2	0	2
Neuronal acetylcholine receptor subunit beta-4	0	2	0	2
Neuronal acetylcholine receptor subunit alpha-3	0	2	0	2
Soluble acetylcholine receptor	0	1	0	1
5-hydroxytryptamine receptor 3C	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-2	0	2	0	2
Neuronal acetylcholine receptor subunit beta-2	0	2	1	3
Neuronal acetylcholine receptor subunit alpha-10	0	2	2	5
Neuronal acetylcholine receptor subunit alpha-6	0	2	0	2
Integrin beta	0	0	1	1
Glycoprotein IIb	0	0	1	1
beta-2 adrenergic receptor	2	0	0	2
Voltage-dependent L-type calcium channel subunit alpha-1C	0	2	0	2
Phospholipase A2, membrane associated	0	1	0	2
Voltage-dependent L-type calcium channel subunit alpha-1C	0	2	0	2
3-oxo-5-alpha-steroid 4-dehydrogenase 1	0	1	0	1
Platelet-activating factor receptor	0	0	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	1	0	1
3-oxo-5-alpha-steroid 4-dehydrogenase 2	0	1	0	1
C-C chemokine receptor type 2	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	1	0	1
C-terminal-binding protein 1	1	0	0	1
Myosin light chain kinase, smooth muscle	0	1	0	1
Potassium channel subfamily K member 2	0	1	0	1
Indoleamine 2,3-dioxygenase 2	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1F	0	1	0	1
CDGSH iron-sulfur domain-containing protein 1	0	2	0	2
Snake venom metalloproteinase BaP1	0	1	0	1
MBT domain-containing protein 1	0	1	0	1
Lethal(3)malignant brain tumor-like protein 4	0	1	0	1
Lethal(3)malignant brain tumor-like protein 3	0	1	0	1
Lethal(3)malignant brain tumor-like protein 1	0	1	0	1
Nrf2	1	0	0	1
Microphthalmia-associated transcription factor	0	0	0	1
caspase recruitment domain family, member 15	0	1	0	1
receptor-interacting serine/threonine-protein kinase 2 isoform 1	0	1	0	1
Beta lactamase (plasmid)	0	1	0	1
WRN	1	0	0	1
microphthalmia-associated transcription factor isoform 9	0	1	0	1
Chain A, cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	0	1	0	1
hexokinase-4 isoform 1	1	0	0	1
glucokinase regulatory protein	1	0	0	1
Vascular endothelial growth factor receptor 1	0	1	0	1
Serine hydroxymethyltransferase, mitochondrial	0	1	0	1
Vascular endothelial growth factor receptor 3	0	1	0	1
Vascular endothelial growth factor receptor 2	0	1	0	1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	0	2	0	2
vasopressin V1b receptor	1	0	0	1
Tumor necrosis factor	0	1	0	1
Chain A, Immunoglobulin	0	0	1	1
Chain B, Immunoglobulin	0	0	1	1
Cholinesterase	0	1	0	1
Muscarinic acetylcholine receptor M5	0	0	1	2
Muscarinic acetylcholine receptor M3	0	0	1	2
Muscarinic acetylcholine receptor M2	0	0	1	2
ClpP	2	0	0	2
Hsf1 protein	0	0	1	1
Alpha-1A adrenergic receptor	0	0	1	1
Alpha-1A adrenergic receptor	0	2	0	2
Alpha-1B adrenergic receptor	0	1	0	1
Alpha-1A adrenergic receptor	0	3	1	4
Alpha-1B adrenergic receptor	0	3	1	4
Nischarin	0	1	0	1
mu-type opioid receptor isoform MOR-1	0	0	1	1
5-hydroxytryptamine receptor 2A	0	0	1	1
Muscarinic acetylcholine receptor DM1	0	1	0	1
luciferase	0	0	0	1
Progesterone receptor	0	2	0	3
Glucocorticoid receptor	0	1	1	2
Glucocorticoid receptor	0	0	1	1
Mineralocorticoid receptor	0	2	1	3
Glutamine synthetase	0	0	1	1
Nociceptin receptor	0	0	1	1
Chain A, dATP pyrophosphohydrolase	0	1	0	1
Chain A, Adenylate cyclase type 5	0	1	0	1
Chain B, Adenylate cyclase type 2	0	1	0	1
N	0	1	0	1
DNA-directed RNA polymerase subunit alpha	0	1	0	1
DNA-directed RNA polymerase subunit omega	0	1	0	1
DNA-directed RNA polymerase subunit beta'	0	1	0	1
DNA-directed RNA polymerase subunit beta	0	1	0	1
Phospholipase A2, membrane associated	0	1	0	1
Acidic phospholipase A2 2	0	1	0	1
2,3-bisphosphoglycerate-independent phosphoglycerate mutase	1	0	0	1
Solute carrier family 22 member 1	0	3	0	4
Solute carrier family 22 member 2	0	2	0	3
PA-I galactophilic lectin	0	0	1	1
hemoglobin subunit beta	1	0	0	1
Quinolone resistance protein NorA	0	1	0	2
DNA topoisomerase 1	0	2	0	2
Chromaffin granule amine transporter	0	1	0	1
Synaptic vesicular amine transporter	0	1	0	1
Synaptic vesicular amine transporter	0	1	0	1
Chain A, PLASMA RETINOL-BINDING PROTEIN PRECURSOR	0	0	1	1
Retinol-binding protein 4	0	0	1	1
Beta-lactoglobulin	0	0	1	1
Neuraminidase	0	2	0	2
Lysine-specific histone demethylase 1A	0	1	0	1
L-lactate dehydrogenase A chain	0	1	0	1
Chymotrypsinogen A	0	1	0	1
Neuraminidase	0	1	0	1
Beta-lactamase	0	1	0	1
Sialidase	0	1	0	1
Cystic fibrosis transmembrane conductance regulator	0	0	1	1
Prolyl endopeptidase	0	1	0	1
Mitogen-activated protein kinase 10	0	1	0	1
Substance-K receptor	0	1	0	1
Neuromedin-U receptor 2	0	0	1	1
Estrogen receptor beta	0	1	0	2
Inhibitor of nuclear factor kappa-B kinase subunit beta	0	0	0	1
5'-AMP-activated protein kinase subunit beta-2	0	0	0	1
Polymerase acidic protein	0	0	1	1
Stromelysin-1	0	1	1	2
Tyrosine-protein phosphatase YopH	0	1	0	1
High mobility group protein B1	0	0	1	1
Prolyl 4-hydroxylase subunit alpha-1	0	1	0	1
Tyrosine-protein phosphatase non-receptor type 1	0	1	0	3
Estrogen receptor	0	1	0	2
Cystathionine gamma-lyase	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-1	0	0	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-2	0	0	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-1	0	0	0	1
Ubiquitin-like domain-containing CTD phosphatase 1	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-3	0	0	0	1
5'-AMP-activated protein kinase subunit gamma-2	0	0	0	1
5'-AMP-activated protein kinase subunit beta-1	0	0	0	1
Hematopoietic prostaglandin D synthase	0	1	0	1
Complement C5	0	0	1	1
Retinoic acid receptor RXR-alpha	0	1	0	1
Glycine receptor subunit alpha-1	0	0	1	1
tyrosine-protein phosphatase non-receptor type 7 isoform 2	0	1	0	1
Tetracycline resistance protein, class B	0	0	0	1
Multidrug transporter MdfA	0	1	0	1
Neutrophil collagenase	0	1	0	1
Cannabinoid receptor 1	0	1	0	1
P2Y purinoceptor 12	0	1	0	1
Solute carrier family 22 member 11	0	0	0	1
Protein-arginine deiminase type-4	0	1	0	1
Solute carrier family 22 member 7	0	0	0	1
Solute carrier family 22 member 5	0	0	0	1
Solute carrier family 22 member 3	0	0	0	1
Solute carrier family 22 member 4	0	0	0	1
Solute carrier family 22 member 4	0	1	0	1
Solute carrier family 22 member 3	0	0	0	1
Solute carrier family 22 member 5	0	0	0	1
Solute carrier family 22 member 4	0	0	0	1
Chain A, Pyridoxal kinase	0	1	0	1
Chain A, Pyridoxal Kinase	0	1	0	1
Phosphodiesterase	0	2	0	2
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4C	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
Thyroid hormone receptor beta	0	1	0	1
Adenosine receptor A1	0	2	0	2
Adenosine receptor A1	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	1	0	1
Cathepsin D	0	1	0	1
Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0	1	0	1
Trace amine-associated receptor 1	0	1	0	1
procathepsin L isoform 1 preproprotein	0	1	0	1
Genome polyprotein	0	1	0	1
Ubiquitin carboxyl-terminal hydrolase 1	0	1	0	1
Lysozyme C-1	0	1	0	1
Glycoprotein hormones alpha chain	1	0	0	1
Protein kinase C alpha type	0	1	0	1
Beta-glucuronidase	0	1	0	1
Protein kinase C delta type	0	1	0	1
Protein kinase C epsilon type	0	1	0	1
Protein kinase C zeta type	0	1	0	1
Protein kinase C gamma type	0	1	0	1
Protein kinase C beta type	0	1	0	1
Protein kinase C eta type	0	1	0	1
Calcium-dependent protein kinase 4	0	1	0	1
WD repeat-containing protein 48	0	1	0	1
Emopamil-binding protein-like	0	1	0	1
Protein kinase C theta type	0	1	0	1
Urease subunit alpha	0	1	0	1
Urease subunit beta	0	1	0	1
Vitamin D3 receptor	0	0	0	1
Vitamin K epoxide reductase complex subunit 1-like protein 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1-like protein 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1	0	2	0	2
Alpha-2A adrenergic receptor	0	1	0	1
M-phase inducer phosphatase 1	0	1	0	1
Alpha-2B adrenergic receptor	0	1	0	1
Alpha-2C adrenergic receptor	0	1	0	1
Alpha-2A adrenergic receptor	0	1	0	1
Lysosomal alpha-glucosidase	0	1	0	1
Lysosomal alpha-glucosidase	0	1	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

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Studies (441)

Protein Targets (1,428)

Frostbite

Synonyms(1)

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Studies (441)

Drugs Studied (236)

Protein Targets (1,428)