| Assay ID | Title | Year | Journal | Article |
|---|
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
| Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1
| High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
| Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1
| High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
| Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1
| High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID1745845 | Primary qHTS for Inhibitors of ATXN expression | | | |
| AID651635 | Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression | | | |
| AID1892320 | Inhibition of recombinant Leishmania major PTR1 expressed in Escherichia coli BL21 (DE3) cells using H2B as substrate in presence of cytochrome c and NADPH by envision multilabel reader | 2022 | Journal of medicinal chemistry, 07-14, Volume: 65, Issue:13
| Multitarget, Selective Compound Design Yields Potent Inhibitors of a Kinetoplastid Pteridine Reductase 1. |
| AID1892326 | Selectivity index, ratio of IC50 for human DHFR to IC50 for Trypanosoma brucei DHFR | 2022 | Journal of medicinal chemistry, 07-14, Volume: 65, Issue:13
| Multitarget, Selective Compound Design Yields Potent Inhibitors of a Kinetoplastid Pteridine Reductase 1. |
| AID1892321 | Inhibition of recombinant Trypanosoma brucei DHFR-TS expressed in Escherichia coli BL21 (DE3) cells using dihydrofolate as substrate in presence of NADPH by spectrophotometric analysis | 2022 | Journal of medicinal chemistry, 07-14, Volume: 65, Issue:13
| Multitarget, Selective Compound Design Yields Potent Inhibitors of a Kinetoplastid Pteridine Reductase 1. |
| AID1892325 | Selectivity index, ratio of IC50 for human DHFR to IC50 for Leishmania major PTR1 | 2022 | Journal of medicinal chemistry, 07-14, Volume: 65, Issue:13
| Multitarget, Selective Compound Design Yields Potent Inhibitors of a Kinetoplastid Pteridine Reductase 1. |
| AID1892324 | Selectivity index, ratio of IC50 for human DHFR to IC50 for Trypanosoma brucei PTR1 | 2022 | Journal of medicinal chemistry, 07-14, Volume: 65, Issue:13
| Multitarget, Selective Compound Design Yields Potent Inhibitors of a Kinetoplastid Pteridine Reductase 1. |
| AID1892319 | Inhibition of recombinant Trypanosoma brucei PTR1 expressed in Escherichia coli BL21 (DE3) cells using H2B as substrate in presence of cytochrome c and NADPH by envision multilabel reader | 2022 | Journal of medicinal chemistry, 07-14, Volume: 65, Issue:13
| Multitarget, Selective Compound Design Yields Potent Inhibitors of a Kinetoplastid Pteridine Reductase 1. |
| AID1892323 | Inhibition of recombinant human DHFR expressed in Escherichia coli BL21 (DE3) cells using dihydrofolate as substrate in presence of NADPH by spectrophotometric analysis | 2022 | Journal of medicinal chemistry, 07-14, Volume: 65, Issue:13
| Multitarget, Selective Compound Design Yields Potent Inhibitors of a Kinetoplastid Pteridine Reductase 1. |
| AID1892322 | Inhibition of recombinant Leishmania major DHFR-TS expressed in Escherichia coli BL21 (DE3) cells using dihydrofolate as substrate in presence of NADPH by spectrophotometric analysis | 2022 | Journal of medicinal chemistry, 07-14, Volume: 65, Issue:13
| Multitarget, Selective Compound Design Yields Potent Inhibitors of a Kinetoplastid Pteridine Reductase 1. |
| AID1892327 | Selectivity index, ratio of IC50 for human DHFR to IC50 for Leishmania major DHFR | 2022 | Journal of medicinal chemistry, 07-14, Volume: 65, Issue:13
| Multitarget, Selective Compound Design Yields Potent Inhibitors of a Kinetoplastid Pteridine Reductase 1. |
| AID540299 | A screen for compounds that inhibit the MenB enzyme of Mycobacterium tuberculosis | 2010 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 20, Issue:21
| Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis. |
| AID588519 | A screen for compounds that inhibit viral RNA polymerase binding and polymerization activities | 2011 | Antiviral research, Sep, Volume: 91, Issue:3
| High-throughput screening identification of poliovirus RNA-dependent RNA polymerase inhibitors. |
| AID1159607 | Screen for inhibitors of RMI FANCM (MM2) intereaction | 2016 | Journal of biomolecular screening, Jul, Volume: 21, Issue:6
| A High-Throughput Screening Strategy to Identify Protein-Protein Interaction Inhibitors That Block the Fanconi Anemia DNA Repair Pathway. |
| AID1347152 | Confirmatory screen NINDS AMC qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1347149 | Furin counterscreen qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1347169 | Tertiary RLuc qRT-PCR qHTS assay for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1347168 | HepG2 cells viability qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1347154 | Primary screen GU AMC qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1347153 | Confirmatory screen GU AMC qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1508630 | Primary qHTS for small molecule stabilizers of the endoplasmic reticulum resident proteome: Secreted ER Calcium Modulated Protein (SERCaMP) assay | 2021 | Cell reports, 04-27, Volume: 35, Issue:4
| A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. |
| AID1347161 | Confirmatory screen NINDS Rhodamine qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1347167 | Vero cells viability qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID493017 | Wombat Data for BeliefDocking | 1996 | Journal of medicinal chemistry, Jun-21, Volume: 39, Issue:13
| Synthesis and biological evaluation of N alpha-(4-amino-4-deoxy-10-methylpteroyl)-DL-4,4-difluoroornithine. |
| AID493017 | Wombat Data for BeliefDocking | 2000 | Journal of medicinal chemistry, Oct-19, Volume: 43, Issue:21
| Computational predictions of binding affinities to dihydrofolate reductase: synthesis and biological evaluation of methotrexate analogues. |
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
| Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1
| High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
| Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1
| High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
| Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1
| High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID651635 | Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression | | | |
| AID1745845 | Primary qHTS for Inhibitors of ATXN expression | | | |
| AID504812 | Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign | 2010 | Endocrinology, Jul, Volume: 151, Issue:7
| A small molecule inverse agonist for the human thyroid-stimulating hormone receptor. |
| AID504810 | Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign | 2010 | Endocrinology, Jul, Volume: 151, Issue:7
| A small molecule inverse agonist for the human thyroid-stimulating hormone receptor. |
| AID334276 | Antiproliferative activity against human HT1080 cells after 72 hrs by MTT assay | 2002 | Journal of natural products, May, Volume: 65, Issue:5
| Constituents of Chinese propolis and their antiproliferative activities. |
| AID1404434 | Cytotoxicity against human HepG2 cells assessed as decrease in cell viability by MTT assay | 2018 | Journal of natural products, 04-27, Volume: 81, Issue:4
| Penicilindoles A-C, Cytotoxic Indole Diterpenes from the Mangrove-Derived Fungus Eupenicillium sp. HJ002. |
| AID1637318 | Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 2 days by MTT assay | 2016 | Bioorganic & medicinal chemistry, 10-01, Volume: 24, Issue:19
| In vitro cytotoxicity of novel 2,5,7-tricarbo-substituted indoles derived from 2-amino-5-bromo-3-iodoacetophenone. |
| AID1236896 | Cytotoxicity against human DU145 cells incubated from day 2 to day 4 by CCK8 assay | 2015 | Bioorganic & medicinal chemistry, Jul-01, Volume: 23, Issue:13
| Synthesis, topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship study of 2-phenyl- or hydroxylated 2-phenyl-4-aryl-5H-indeno[1,2-b]pyridines. |
| AID1882814 | Anticancer activity against human A549 cells | 2022 | European journal of medicinal chemistry, May-05, Volume: 235 | Recent advances of antitumor shikonin/alkannin derivatives: A comprehensive overview focusing on structural classification, synthetic approaches, and mechanisms of action. |
| AID1762256 | Cytotoxicity against human AG01523 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay | | | |
| AID456254 | Cytotoxicity against human K562 cells after 4 days by ELISA reader assay | 2010 | Bioorganic & medicinal chemistry, Jan-01, Volume: 18, Issue:1
| 2-Thienyl-4-furyl-6-aryl pyridine derivatives: synthesis, topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship study. |
| AID462322 | Cytotoxicity against human MCF7 cells in presence of 10% fetal bovine serum | 2010 | Bioorganic & medicinal chemistry, Mar-15, Volume: 18, Issue:6
| Synthesis of 2-(thienyl-2-yl or -3-yl)-4-furyl-6-aryl pyridine derivatives and evaluation of their topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship. |
| AID1875129 | Growth inhibition of human HCT-15 cells by SRB assay | 2022 | Journal of natural products, 09-23, Volume: 85, Issue:9
| Aspersterols A-D, Ergostane-Type Sterols with an Unusual Unsaturated Side Chain from the Deep-Sea-Derived Fungus |
| AID1505073 | Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay | 2018 | Journal of natural products, 01-26, Volume: 81, Issue:1
| Ophiobolins from the Mangrove Fungus Aspergillus ustus. |
| AID1401030 | Antiproliferative activity against human MCF7/ADR cells after 96 hrs by MTT assay | 2017 | European journal of medicinal chemistry, Dec-01, Volume: 141 | Synthesis, anticancer evaluation and pharmacokinetic study of novel 10-O-phenyl ethers of dihydroartemisinin. |
| AID1424263 | Antitumor activity against mouse S180 cells implanted in ICR mouse assessed as inhibition of tumor growth at 0.1 umol/kg, ip for 7 consecutive days starting 24 hrs after tumor cell inoculation relative to untreated control | 2017 | European journal of medicinal chemistry, Dec-15, Volume: 142 | Recent insights into synthetic β-carbolines with anti-cancer activities. |
| AID461178 | Antitumor activity against human K562 cells | 2010 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 20, Issue:3
| Polar 3-alkylidene-5-pivaloyloxymethyl-5'-hydroxymethyl-gamma-lactones as protein kinase C ligands and antitumor agents. |
| AID1168524 | Toxicity in mouse S180 cells allografted mouse assessed as heart weight at 1 umol/kg, ip for 7 consecutive days measured 24 hrs after last dose (Rvb = 0.12 +/- 0.02 g) | 2014 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 24, Issue:22
| Synthesis and biological evaluation of a novel class of coumarin derivatives. |
| AID452681 | Cytotoxicity against human MCF7 cells after 3 days | 2010 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 20, Issue:1
| 2,6-Dithienyl-4-furyl pyridines: Synthesis, topoisomerase I and II inhibition, cytotoxicity, structure-activity relationship, and docking study. |
| AID1308396 | Inhibition of human topoisomerase 2-mediated DNA cleavage at 5 uM using supercoiled pHOT1 plasmid as substrate by agarose gel electrophoresis | 2016 | Journal of medicinal chemistry, 05-26, Volume: 59, Issue:10
| H2S-Donating Doxorubicins May Overcome Cardiotoxicity and Multidrug Resistance. |
| AID1486763 | Antiproliferative activity against human HCT15 cells after 72 hrs by CCK8 assay | 2017 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 27, Issue:15
| 2-Chlorophenyl-substituted benzofuro[3,2-b]pyridines with enhanced topoisomerase inhibitory activity: The role of the chlorine substituent. |
| AID1566579 | Cytotoxicity against human PC3 cells | 2019 | European journal of medicinal chemistry, Sep-01, Volume: 177 | Developments in the anticancer activity of structurally modified curcumin: An up-to-date review. |
| AID592928 | Cytotoxicity against human A2780 cells by sulforhodamine B method | 2011 | Bioorganic & medicinal chemistry, Apr-15, Volume: 19, Issue:8
| Synthesis and biological evaluation of estradiol linked pyrrolo[2,1-c][1,4]benzodiazepine (PBD) conjugates as potential anticancer agents. |
| AID1441894 | Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay | 2017 | European journal of medicinal chemistry, Mar-31, Volume: 129 | Design, synthesis, biological evaluation and molecular modeling study of novel macrocyclic bisbibenzyl analogues as antitubulin agents. |
| AID1355287 | Cytotoxicity against human HCT15 cells assessed as inhibition of cell proliferation measured after 72 hrs by sulforhodamine B assay | 2018 | Journal of natural products, 06-22, Volume: 81, Issue:6
| Cytotoxic Drimane Sesquiterpenoids Isolated from Perenniporia maackiae. |
| AID1132920 | Cardiotoxicity in rat EEG model | 1978 | Journal of medicinal chemistry, Aug, Volume: 21, Issue:8
| Antitumor anthracycline antibiotics. Structure-activity and structure-cardiotoxicity relationships of rubidazone analogues. |
| AID478258 | Cytotoxicity against human vinblastine-resistant KBV1 cells after 72 hrs by MTT assay | 2010 | European journal of medicinal chemistry, May, Volume: 45, Issue:5
| Modulation of doxorubicin activity in cancer cells by conjugation with fatty acyl and terpenyl hydrazones. |
| AID548272 | Cytotoxicity against african green monkey COS1 cells assessed as reduction in cell viability after 32 hrs by luminescent assay | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7
| Minigenome-based reporter system suitable for high-throughput screening of compounds able to inhibit Ebolavirus replication and/or transcription. |
| AID1176797 | Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by MTT assay | 2015 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 25, Issue:3
| Development of constrained tamoxifen mimics and their antiproliferative properties against breast cancer cells. |
| AID1888035 | Antiproliferative activity against human T47D cells after 72 hrs by EZ-Cytox colorimetric assay | 2022 | European journal of medicinal chemistry, Jan-05, Volume: 227 | Identification of new halogen-containing 2,4-diphenyl indenopyridin-5-one derivative as a boosting agent for the anticancer responses of clinically available topoisomerase inhibitors. |
| AID1437494 | Cytotoxicity against human WI38 cells after 72 hrs by CCK8 assay | 2017 | Journal of natural products, 01-27, Volume: 80, Issue:1
| Nanomolar Antimalarial Agents against Chloroquine-Resistant Plasmodium falciparum from Medicinal Plants and Their Structure-Activity Relationships. |
| AID1337586 | Antiproliferative activity against human T47D cells measured after 72 hrs by CCK8 assay | 2017 | European journal of medicinal chemistry, Jan-05, Volume: 125 | Fluorescein hydrazones: A series of novel non-intercalative topoisomerase IIα catalytic inhibitors induce G1 arrest and apoptosis in breast and colon cancer cells. |
| AID1668783 | Cytotoxicity against human A549 cells incubated for 48 hrs by MTT assay | 2020 | Journal of natural products, 05-22, Volume: 83, Issue:5
| Cytotoxic Heptaketides from the Endolichenic Fungus |
| AID376375 | Antitumor activity against human HT-29 cells | 1999 | Journal of natural products, Nov, Volume: 62, Issue:11
| Synthesis of 11,12-epoxydrim-8,12-en-11-ol, 11,12-diacetoxydrimane, and warburganal from (-)-sclareol. |
| AID490208 | Cytotoxicity against human 22Rv1 cells by MTT assay | 2010 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 20, Issue:13
| Synthesis of novel beta-carbolines with efficient DNA-binding capacity and potent cytotoxicity. |
| AID1776430 | Cytotoxicity against human A549 cells assessed as cell viability inhibition for 48 hrs by MTT assay | 2021 | Journal of natural products, 05-28, Volume: 84, Issue:5
| Diverse Prenylated Bibenzyl Enantiomers from the Chinese Liverwort |
| AID619820 | Cytotoxicity against human HepG2 cells by MTT assay | 2011 | European journal of medicinal chemistry, Oct, Volume: 46, Issue:10
| Synthesis and biological evaluation of 1,9-disubstituted β-carbolines as potent DNA intercalating and cytotoxic agents. |
| AID1185779 | Growth inhibition of human MGC803 cells after 72 hrs by MTT assay | 2014 | European journal of medicinal chemistry, Sep-12, Volume: 84 | Synthesis and biological evaluation of novel 6-chloro-quinazolin derivatives as potential antitumor agents. |
| AID1436222 | Cytotoxicity against human HeLa cells assessed as cell growth at 10'-5 M after 48 hrs by SRB assay relative to control | 2017 | European journal of medicinal chemistry, Jan-27, Volume: 126 | Piperlongumine derived cyclic sulfonamides (sultams): Synthesis and in vitro exploration for therapeutic potential against HeLa cancer cell lines. |
| AID1145594 | Antiproliferative activity against MEF after 72 hrs | 1976 | Journal of medicinal chemistry, May, Volume: 19, Issue:5
| Stereocontrolled glycosidation of daunomycinone. Synthesis and biological evaluation of 6-hydroxy-L-arabino analogues of antitumor anthracyclines. |
| AID249857 | Percent control of human mammary adenocarcinoma MCF-7 cell line proliferation at 0.3 ng/mL | 2004 | Bioorganic & medicinal chemistry letters, Sep-20, Volume: 14, Issue:18
| Formation of squaric acid amides of anthracycline antibiotics. Synthesis and cytotoxic properties. |
| AID478017 | Antiproliferative activity against human K562/A02 cells after 72 hrs by sulforhodamine B assay | 2010 | Journal of medicinal chemistry, Apr-22, Volume: 53, Issue:8
| A series of alpha-heterocyclic carboxaldehyde thiosemicarbazones inhibit topoisomerase IIalpha catalytic activity. |
| AID1486951 | Inhibition of ABCB1 in human K562/A02 cells assessed as potentiation of adriamycin-induced cytotoxicity by measuring ADR IC50 at 5 uM measured after 48 hrs by MTT assay (Rvb = 43.75 to 96.91 uM) | 2017 | Bioorganic & medicinal chemistry, 08-01, Volume: 25, Issue:15
| Synthesis and biological evaluation of JL-A7 derivatives as potent ABCB1 inhibitors. |
| AID1337477 | Antiproliferative activity against HEK293 cells after 72 hrs by CCK8 assay | 2017 | European journal of medicinal chemistry, Jan-05, Volume: 125 | Novel 2-aryl-4-(4'-hydroxyphenyl)-5H-indeno[1,2-b]pyridines as potent DNA non-intercalative topoisomerase catalytic inhibitors. |
| AID1875133 | Growth inhibition of human PC-3 cells by SRB assay | 2022 | Journal of natural products, 09-23, Volume: 85, Issue:9
| Aspersterols A-D, Ergostane-Type Sterols with an Unusual Unsaturated Side Chain from the Deep-Sea-Derived Fungus |
| AID673200 | Antiproliferative activity against human A549 cells after 72 hrs by SRB assay | 2012 | Bioorganic & medicinal chemistry, Aug-01, Volume: 20, Issue:15
| Synthesis and in vitro antiproliferative activity of new 11-aminoalkylamino-substituted 5H- and 6H-indolo[2,3-b]quinolines; structure-activity relationships of neocryptolepines and 6-methyl congeners. |
| AID8998 | Cytotoxicity against A-549 cell line in the purdue cell culture screen was determined | 1999 | Bioorganic & medicinal chemistry letters, Feb-08, Volume: 9, Issue:3
| On the relationship of OSW-1 to the cephalostatins. |
| AID1783253 | Cytotoxicity against human A549 cells assessed as inhibition of proliferation incubated for 72 hrs by MTT assay | | | |
| AID1762255 | Cytotoxicity against human PC-3 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay | | | |
| AID1612623 | Antiproliferative activity against human VCR-resistant K562/VCR cells after 72 hrs by MTT assay | 2019 | European journal of medicinal chemistry, Feb-01, Volume: 163 | Design, synthesis and biological evaluation of quinoline-indole derivatives as anti-tubulin agents targeting the colchicine binding site. |
| AID734086 | Growth inhibition against human IGROV cells after 72 hrs by inverted microscopy | 2013 | European journal of medicinal chemistry, Apr, Volume: 62 | Synthesis, cytotoxicity and antiplasmodial activity of novel ent-kaurane derivatives. |
| AID512047 | Cytotoxicity against human PC3 cells after 48 hrs by SRB assay | 2010 | European journal of medicinal chemistry, Sep, Volume: 45, Issue:9
| Synthesis and biological evaluation of cinnamido linked pyrrolo[2,1-c][1,4]benzodiazepines as antimitotic agents. |
| AID1356000 | Cytotoxicity against human SH-SY5Y cells after 72 hrs by MTT assay | 2018 | Journal of natural products, 07-27, Volume: 81, Issue:7
| Aniline-Tetramic Acids from the Deep-Sea-Derived Fungus Cladosporium sphaerospermum L3P3 Cultured with the HDAC Inhibitor SAHA. |
| AID619817 | Cytotoxicity against human KB cells by MTT assay | 2011 | European journal of medicinal chemistry, Oct, Volume: 46, Issue:10
| Synthesis and biological evaluation of 1,9-disubstituted β-carbolines as potent DNA intercalating and cytotoxic agents. |
| AID1869701 | Cytotoxicity against human PC-3 cells assessed as reduction in cell viability incubated for 72 hrs by SRB assay | 2022 | Journal of natural products, 07-22, Volume: 85, Issue:7
| Suncheonosides E-M and Benzothioate Derivatives from the Marine-Derived |
| AID461390 | Antitumor activity against human SK-MEL-5 cells | 2010 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 20, Issue:3
| Polar 3-alkylidene-5-pivaloyloxymethyl-5'-hydroxymethyl-gamma-lactones as protein kinase C ligands and antitumor agents. |
| AID1577579 | Antiproliferative activity against human T47D cells measured after 72 hrs by EZ-Cytox assay | 2019 | Journal of medicinal chemistry, 09-12, Volume: 62, Issue:17
| Discovery and Biological Evaluations of Halogenated 2,4-Diphenyl Indeno[1,2- |
| AID1459362 | Cytotoxicity against human A549 cells by MTT assay | 2016 | Journal of natural products, 10-28, Volume: 79, Issue:10
| Bissubvilides A and B, Cembrane-Capnosane Heterodimers from the Soft Coral Sarcophyton subviride. |
| AID1359657 | Antiproliferative activity against human MCF7/ADR cells after 48 to 72 hrs by MTT assay | 2018 | European journal of medicinal chemistry, May-25, Volume: 152 | Discovery of novel β-carboline/acylhydrazone hybrids as potent antitumor agents and overcome drug resistance. |
| AID1288093 | Cytotoxicity against human T47D cells after 48 hrs by CCK8 assay | 2016 | European journal of medicinal chemistry, May-04, Volume: 113 | A new series of 2-phenol-4-aryl-6-chlorophenyl pyridine derivatives as dual topoisomerase I/II inhibitors: Synthesis, biological evaluation and 3D-QSAR study. |
| AID1904126 | Cytotoxicity against human K562 cells after 48 hrs by MTT assay | 2022 | European journal of medicinal chemistry, Apr-05, Volume: 233 | Exploration of novel phthalazinone derivatives as potential efflux transporter inhibitors for reversing multidrug resistance and improving the oral absorption of paclitaxel. |
| AID484748 | Cytotoxicity against human SiHa cells after 48 hrs by SRB assay | 2010 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 20, Issue:11
| Synthesis, anticancer activity and apoptosis inducing ability of anthranilamide-PBD conjugates. |
| AID1331841 | Cytotoxicity against human MCF10A cells assessed as cell growth inhibition after 48 hrs by SRB assay | 2016 | Journal of natural products, 09-23, Volume: 79, Issue:9
| Isolation of Coralmycins A and B, Potent Anti-Gram Negative Compounds from the Myxobacteria Corallococcus coralloides M23. |
| AID1875132 | Growth inhibition of human ACHN cells by SRB assay | 2022 | Journal of natural products, 09-23, Volume: 85, Issue:9
| Aspersterols A-D, Ergostane-Type Sterols with an Unusual Unsaturated Side Chain from the Deep-Sea-Derived Fungus |
| AID592931 | Cytotoxicity against human SiHa cells by sulforhodamine B method | 2011 | Bioorganic & medicinal chemistry, Apr-15, Volume: 19, Issue:8
| Synthesis and biological evaluation of estradiol linked pyrrolo[2,1-c][1,4]benzodiazepine (PBD) conjugates as potential anticancer agents. |
| AID1176796 | Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay | 2015 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 25, Issue:3
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| AID1583358 | Antiproliferative activity against human U118MG cells assessed as reduction in cell viability after 72 hrs by MTT assay | 2020 | Journal of medicinal chemistry, 02-27, Volume: 63, Issue:4
| Identification of Parthenolide Dimers as Activators of Pyruvate Kinase M2 in Xenografts of Glioblastoma Multiforme in Vivo. |
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| Notolutesins A-J, dolabrane-type diterpenoids from the Chinese liverwort Notoscyphus lutescens. |
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| Exploration of 2-((Pyridin-4-ylmethyl)amino)nicotinamide Derivatives as Potent Reversal Agents against P-Glycoprotein-Mediated Multidrug Resistance. |
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| Resorcinosides A and B, Glycosylated Alkylresorcinols from a Marine-Derived Strain of the Fungus |
| AID1272242 | Cytotoxicity against human HeLa cells | 2016 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 26, Issue:3
| Efficiently functionalized oxacalix[4]arenes: Synthesis, characterization and exploration of their biological profile as novel HDAC inhibitors. |
| AID1264616 | Cytotoxicity against human MGC803 cells after 72 hrs by MTT assay | 2015 | Journal of natural products, Nov-25, Volume: 78, Issue:11
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| Synthesis and biological evaluation of estradiol linked pyrrolo[2,1-c][1,4]benzodiazepine (PBD) conjugates as potential anticancer agents. |
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| AID512240 | Anticancer activity against human KB cells after 48 hrs by SRB assay | 2010 | European journal of medicinal chemistry, Sep, Volume: 45, Issue:9
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| AID592697 | Cytotoxicity against human COLO205 cells after 48 hrs by sulforhodamine B based ELISA | 2011 | Bioorganic & medicinal chemistry, Apr-01, Volume: 19, Issue:7
| Synthesis of a new 4-aza-2,3-didehydropodophyllotoxin analogues as potent cytotoxic and antimitotic agents. |
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| AID621709 | Binding affinity to human serum transferrin after 12 hrs at pH 4.8 by spectrofluorometer method | 2011 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 21, Issue:19
| Constructing transferrin receptor targeted drug delivery system by using doxorubicin hydrochloride and vanadocene dichloride. |
| AID633825 | Cytotoxicity against human 647V cells after 24 hrs by MTT assay | 2012 | Bioorganic & medicinal chemistry, Jan-01, Volume: 20, Issue:1
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| Bafilomycins and Odoriferous Sesquiterpenoids from Streptomyces albolongus Isolated from Elephas maximus Feces. |
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| Recent synthetic and medicinal perspectives of tryptanthrin. |
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| 6-OH-Phenanthroquinolizidine Alkaloid and Its Derivatives Exert Potent Anticancer Activity by Delaying S Phase Progression. |
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| Light-Regulated NO Release as a Novel Strategy To Overcome Doxorubicin Multidrug Resistance. |
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| Identification of Parthenolide Dimers as Activators of Pyruvate Kinase M2 in Xenografts of Glioblastoma Multiforme in Vivo. |
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| Asperunguisins A-F, Cytotoxic Asperane Sesterterpenoids from the Endolichenic Fungus Aspergillus unguis. |
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| Replacing d-Glucosamine with Its l-Enantiomer in Glycosylated Antitumor Ether Lipids (GAELs) Retains Cytotoxic Effects against Epithelial Cancer Cells and Cancer Stem Cells. |
| AID1387377 | Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay | 2018 | Journal of natural products, 09-28, Volume: 81, Issue:9
| Dinghupeptins A-D, Chymotrypsin Inhibitory Cyclodepsipeptides Produced by a Soil-Derived Streptomyces. |
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| AID1905059 | Antiproliferative activity against human paclitaxel-resistant A2780/TAX cells assessed as cell viability incubated for 48 hrs by MTT assay | 2022 | Journal of medicinal chemistry, 03-24, Volume: 65, Issue:6
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| Replacing d-Glucosamine with Its l-Enantiomer in Glycosylated Antitumor Ether Lipids (GAELs) Retains Cytotoxic Effects against Epithelial Cancer Cells and Cancer Stem Cells. |
| AID1358357 | Inhibition of cancer stem cell population of human PANC1 cells assessed as CD24+/CD44+/ESA+ cell population level at 0.15 uM after 48 hrs by flow cytometric analysis (Rvb = 1.7%) | 2018 | European journal of medicinal chemistry, May-10, Volume: 151 | Syntheses and anti-pancreatic cancer activities of rakicidin A analogues. |
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| Synthesis and Antitumor Activity of Diosgenin Hydroxamic Acid and Quaternary Phosphonium Salt Derivatives. |
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| The inhibitory effect of kokusaginine on the growth of human breast cancer cells and MDR-resistant cells is mediated by the inhibition of tubulin assembly. |
| AID1057309 | Growth inhibition of human MDA-MB-231 cells after 72 hrs by CellTiter-Blue assay | 2013 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 23, Issue:24
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| Alpha-trifluoromethylated acyloins induce apoptosis in human oral tumor cell lines. |
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| AID636831 | Cytotoxicity against human KB cells by resazurin microplate assay | 2011 | Journal of natural products, Oct-28, Volume: 74, Issue:10
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| AID170954 | Compound was evaluated for augmentation of rat liver microsomal oxygen consumption relative to doxorubicin | 1981 | Journal of medicinal chemistry, Jun, Volume: 24, Issue:6
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| Resorcinosides A and B, Glycosylated Alkylresorcinols from a Marine-Derived Strain of the Fungus |
| AID1405489 | Antiproliferative activity against human HCT116 cells after 72 hrs by MTT assay | 2018 | European journal of medicinal chemistry, Aug-05, Volume: 156 | Copper(I) oxide nanoparticles catalyzed click chemistry based synthesis of melampomagnolide B-triazole conjugates and their anti-cancer activities. |
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| AID478303 | Induction of apoptosis in human HL60 cells assessed as appearance of intact mitochondria in cytosol at 5 uM after 6 hrs using JC1 dye relative to control | 2010 | European journal of medicinal chemistry, May, Volume: 45, Issue:5
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| AID613196 | Antitumor activity against human MDA-MB-231 cells after 72 hrs by SRB assay | 2011 | Journal of natural products, Jul-22, Volume: 74, Issue:7
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| AID512026 | Cytotoxicity against human COLO205 cells after 48 hrs by SRB assay | 2010 | European journal of medicinal chemistry, Sep, Volume: 45, Issue:9
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| AID1145595 | Inhibition of Murine sarcoma virus (Moloney) foci formation in MEF after 72 hrs | 1976 | Journal of medicinal chemistry, May, Volume: 19, Issue:5
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| Ophiobolins from the Mangrove Fungus Aspergillus ustus. |
| AID592420 | Cytotoxicity against human MCF7 cells assessed as inhibition of cell proliferation after 72 hrs by SRB assay | 2011 | Journal of natural products, Mar-25, Volume: 74, Issue:3
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| AID1423929 | Cytotoxicity against human SMMC7721 cells assessed as inhibition of growth incubated for 72 hrs by MTT assay | 2017 | Journal of natural products, 04-28, Volume: 80, Issue:4
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| AID1227994 | Cytotoxic activity against human H460 cells by MTT method | 2015 | Journal of natural products, Apr-24, Volume: 78, Issue:4
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| Suncheonosides E-M and Benzothioate Derivatives from the Marine-Derived |
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| AID1227998 | Cytotoxic activity against human HeLa cells by MTT method | 2015 | Journal of natural products, Apr-24, Volume: 78, Issue:4
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| Replacing d-Glucosamine with Its l-Enantiomer in Glycosylated Antitumor Ether Lipids (GAELs) Retains Cytotoxic Effects against Epithelial Cancer Cells and Cancer Stem Cells. |
| AID138191 | Compound was evaluated for antitumor activity in mice injected intraperitoneal with leukemia P-388 cells, treated on days 5, 9, and 13 th day at 2 mg/kg | 1981 | Journal of medicinal chemistry, Jun, Volume: 24, Issue:6
| Synthesis and preliminary antitumor evaluation of 5-iminodoxorubicin. |
| AID1822517 | Cytotoxicity in human NCI-ADR-RES assessed as inhibition in cell growth measured after 24 hrs by MTT assay | 2022 | Journal of medicinal chemistry, 02-10, Volume: 65, Issue:3
| Structure-Based Design and Synthesis of N-Substituted 3-Amino-β-Carboline Derivatives as Potent αβ-Tubulin Degradation Agents. |
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| AID1612610 | Antiproliferative activity against human K562 cells after 72 hrs by MTT assay | 2019 | European journal of medicinal chemistry, Feb-01, Volume: 163 | Design, synthesis and biological evaluation of quinoline-indole derivatives as anti-tubulin agents targeting the colchicine binding site. |
| AID569516 | Cytotoxicity against human KB cells after 48 hrs by sulforhodamine B assay | 2011 | European journal of medicinal chemistry, Feb, Volume: 46, Issue:2
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| AID1168525 | Toxicity in mouse S180 cells allografted mouse assessed as liver weight at 1 umol/kg, ip for 7 consecutive days measured 24 hrs after last dose (Rvb = 1.84 +/- 0.32 g) | 2014 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 24, Issue:22
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| AID689427 | Cytotoxicity against human A549 cells after 72 hrs by SRB assay | 2012 | Journal of medicinal chemistry, Jun-14, Volume: 55, Issue:11
| Synthesis and biological evaluation of new amino acid and dipeptide derivatives of neocryptolepine as anticancer agents. |
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| AID595893 | Cytotoxicity against human MCF7 cells after 45 hrs by resazurin microplate assay | 2011 | Journal of natural products, Apr-25, Volume: 74, Issue:4
| Bioactive compounds from the scale insect pathogenic fungus Conoideocrella tenuis BCC 18627. |
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| The inhibitory effect of kokusaginine on the growth of human breast cancer cells and MDR-resistant cells is mediated by the inhibition of tubulin assembly. |
| AID404063 | Cytotoxicity against human HT1080 cells after 24 hrs by MTT assay | 1998 | Journal of natural products, Jul, Volume: 61, Issue:7
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| AID1899071 | Antiproliferative activity against human KB-V1 cells measured after 72 hrs by SRB assay | | | |
| AID1277894 | Cytotoxicity against human QG56 cells assessed as cell viability after 48 hrs by MTT assay | 2016 | Bioorganic & medicinal chemistry letters, Feb-15, Volume: 26, Issue:4
| Structure activity relationship, cytotoxicity and evaluation of antioxidant activity of curcumin derivatives. |
| AID478271 | Induction of apoptosis in human HL60 cells assessed as increase of caspase 3 activity at 5 uM after 12 hrs by luminometric assay | 2010 | European journal of medicinal chemistry, May, Volume: 45, Issue:5
| Modulation of doxorubicin activity in cancer cells by conjugation with fatty acyl and terpenyl hydrazones. |
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| H2S-Donating Doxorubicins May Overcome Cardiotoxicity and Multidrug Resistance. |
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| Aniline-Tetramic Acids from the Deep-Sea-Derived Fungus Cladosporium sphaerospermum L3P3 Cultured with the HDAC Inhibitor SAHA. |
| AID1625735 | Cytotoxicity against beta-tubulin 3 overexpressing human A2780T cells assessed as reduction in cell growth after 24 hrs by MTT assay | 2016 | Journal of medicinal chemistry, 06-23, Volume: 59, Issue:12
| Design, Synthesis, and Evaluation of in Vitro and in Vivo Anticancer Activity of 4-Substituted Coumarins: A Novel Class of Potent Tubulin Polymerization Inhibitors. |
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| Ophiobolins from the Mangrove Fungus Aspergillus ustus. |
| AID480111 | Cytotoxicity against human HL60 cells after 2 days by automatic ELISA reader system | 2010 | Bioorganic & medicinal chemistry, May-01, Volume: 18, Issue:9
| Synthesis, topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship study of hydroxylated 2,4-diphenyl-6-aryl pyridines. |
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| AID1490964 | Cytotoxicity against human MCF7/ADM cells after 24 hrs by sulforhodamine B assay | 2017 | Journal of natural products, 05-26, Volume: 80, Issue:5
| Geranylpyrrol A and Piericidin F from Streptomyces sp. CHQ-64 ΔrdmF. |
| AID1378629 | Antifungal activity against Fusarium verticillioides after 8 hrs by conidial germination assay | 2017 | Journal of natural products, 08-25, Volume: 80, Issue:8
| Antifungal and Cytotoxic β-Resorcylic Acid Lactones from a Paecilomyces Species. |
| AID1867123 | Cytotoxicity against human PANC-1 cells assessed as inhibition of cell growth incubated for 72 hrs by SRB assay | 2022 | Journal of natural products, 04-22, Volume: 85, Issue:4
| Cytotoxic Nitrobenzoyl Sesquiterpenoids from an Antarctica Sponge-Derived |
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| 2-Substituted-1-(2-morpholinoethyl)-1H-naphtho[2,3-d]imidazole-4,9-diones: Design, synthesis and antiproliferative activity. |
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| Exploration of 2-((Pyridin-4-ylmethyl)amino)nicotinamide Derivatives as Potent Reversal Agents against P-Glycoprotein-Mediated Multidrug Resistance. |
| AID478012 | Antiproliferative activity against human K562 cells after 72 hrs by sulforhodamine B assay | 2010 | Journal of medicinal chemistry, Apr-22, Volume: 53, Issue:8
| A series of alpha-heterocyclic carboxaldehyde thiosemicarbazones inhibit topoisomerase IIalpha catalytic activity. |
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| Effect of chlorine substituent on cytotoxic activities: Design and synthesis of systematically modified 2,4-diphenyl-5H-indeno[1,2-b]pyridines. |
| AID1430412 | Cytotoxicity against human HeLa cells assessed as cell growth at 10'-6 M after 48 hrs by SRB assay relative to control | 2017 | Bioorganic & medicinal chemistry letters, 03-01, Volume: 27, Issue:5
| Methylsulfonyl benzothiazoles (MSBT) derivatives: Search for new potential antimicrobial and anticancer agents. |
| AID122235 | Antitumor activity against mice bearing P388 leukemia implanted ip on day 0, after treatment with three po doses on day 1,5,9 when the tumor had become systemic; Inactive | 1984 | Journal of medicinal chemistry, May, Volume: 27, Issue:5
| Intensely potent morpholinyl anthracyclines. |
| AID478269 | Induction of apoptosis in human HL60 cells assessed as DNA ladder formation at 5 uM after 24 hrs by agarose gel electrophoresis | 2010 | European journal of medicinal chemistry, May, Volume: 45, Issue:5
| Modulation of doxorubicin activity in cancer cells by conjugation with fatty acyl and terpenyl hydrazones. |
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| AID1421547 | Antiproliferative activity against human A549 cells assessed as inhibition of cell growth at 1 uM after 72 hrs by sulforhodamine B assay relative to control | 2018 | European journal of medicinal chemistry, Oct-05, Volume: 158 | Four new antitumor metabolites isolated from a mutant 3-f-31 strain derived from Penicillium purpurogenum G59. |
| AID122232 | Antitumor activity against mice bearing B16 melanoma implanted ip on day 0, after treatment with three ip doses 10 mg/kg on day 1,5,9 when tumor had become systemic. | 1984 | Journal of medicinal chemistry, May, Volume: 27, Issue:5
| Intensely potent morpholinyl anthracyclines. |
| AID1638223 | Cytotoxicity against human Bel7402/5-FU cells after 72 hrs by MTT assay | 2019 | European journal of medicinal chemistry, Mar-01, Volume: 165 | Discovery and synthesis of sulfur-containing 6-substituted 5,8-dimethoxy-1,4-naphthoquinone oxime derivatives as new and potential anti-MDR cancer agents. |
| AID1663788 | Anticancer activity against human A549 cells assessed as inhibition of cell proliferation | 2020 | Bioorganic & medicinal chemistry letters, 07-15, Volume: 30, Issue:14
| Synthesis and evaluation of novel sulfonamide analogues of 6/7-aminoflavones as anticancer agents via topoisomerase II inhibition. |
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| Cytotoxic and antiplatelet aggregation principles from Aglaia elliptifolia. |
| AID478308 | Cytotoxicity against human HL60 cells assessed as increase in ROS production at 5 uM after 72 hrs by NBT reduction assay relative to control | 2010 | European journal of medicinal chemistry, May, Volume: 45, Issue:5
| Modulation of doxorubicin activity in cancer cells by conjugation with fatty acyl and terpenyl hydrazones. |
| AID510624 | Cytotoxicity against human MDA-MB-231 cells after 4 days by MTT assay | 2010 | European journal of medicinal chemistry, Sep, Volume: 45, Issue:9
| Synthesis and pharmacological evaluation of new methyloxiranylmethoxyxanthone analogues. |
| AID1166322 | Cytotoxicity against human A549 cells after 48 hrs by SRB assay | 2014 | European journal of medicinal chemistry, Nov-24, Volume: 87 | β-Ionone derived apoptosis inducing endoperoxides; Discovery of potent leads for anticancer agents. |
| AID734495 | Growth inhibition against human LoVo/DX cells after 72 hrs by inverted microscopy | 2013 | European journal of medicinal chemistry, Apr, Volume: 62 | Synthesis, cytotoxicity and antiplasmodial activity of novel ent-kaurane derivatives. |
| AID1281585 | Cytotoxicity against HAF assessed as reduction in cell viability after 96 hrs by sulforhodamine B assay | 2016 | European journal of medicinal chemistry, Mar-23, Volume: 111 | Synthesis and biological evaluation of D-ring fused 1,2,3-thiadiazole dehydroepiandrosterone derivatives as antitumor agents. |
| AID1882749 | Anticancer activity against human MGC-803 cells assessed as inhibition of cell proliferation incubated for 48 hrs by MTT assay | 2022 | European journal of medicinal chemistry, May-05, Volume: 235 | Recent advances of antitumor shikonin/alkannin derivatives: A comprehensive overview focusing on structural classification, synthetic approaches, and mechanisms of action. |
| AID478250 | Cytotoxicity against human 518A2 cells after 24 hrs by MTT assay | 2010 | European journal of medicinal chemistry, May, Volume: 45, Issue:5
| Modulation of doxorubicin activity in cancer cells by conjugation with fatty acyl and terpenyl hydrazones. |
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| AID1757282 | Antiproliferative activity against taxol-resistant human HCT-8 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay | 2021 | European journal of medicinal chemistry, Apr-15, Volume: 216 | Discovery of novel N-benzylbenzamide derivatives as tubulin polymerization inhibitors with potent antitumor activities. |
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| Aniline-Tetramic Acids from the Deep-Sea-Derived Fungus Cladosporium sphaerospermum L3P3 Cultured with the HDAC Inhibitor SAHA. |
| AID456251 | Cytotoxicity against human MCF7 cells after 4 days by ELISA reader assay | 2010 | Bioorganic & medicinal chemistry, Jan-01, Volume: 18, Issue:1
| 2-Thienyl-4-furyl-6-aryl pyridine derivatives: synthesis, topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship study. |
| AID480109 | Cytotoxicity against human DU145 cells after 2 days by automatic ELISA reader system | 2010 | Bioorganic & medicinal chemistry, May-01, Volume: 18, Issue:9
| Synthesis, topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship study of hydroxylated 2,4-diphenyl-6-aryl pyridines. |
| AID1481835 | Antiproliferative activity against human K562/ADR cells after 72 hrs by MTT assay | 2017 | Journal of medicinal chemistry, 04-13, Volume: 60, Issue:7
| 6-OH-Phenanthroquinolizidine Alkaloid and Its Derivatives Exert Potent Anticancer Activity by Delaying S Phase Progression. |
| AID1671763 | Inhibition of epithelial-mesenchymal transition in human SMMC-7721 cells assessed as decrease in TGF-beta1-induced vimentin expression at 0.5 uM incubated for 48 hrs by immunofluorescence staining based laser-scanning confocal microscope | 2019 | European journal of medicinal chemistry, Mar-15, Volume: 166 | Excellent antitumor and antimetastatic activities based on novel coumarin/pyrazole oxime hybrids. |
| AID1355289 | Cytotoxicity against human NCI-H23 cells assessed as inhibition of cell proliferation measured after 72 hrs by sulforhodamine B assay | 2018 | Journal of natural products, 06-22, Volume: 81, Issue:6
| Cytotoxic Drimane Sesquiterpenoids Isolated from Perenniporia maackiae. |
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| Synthesis and pharmacological evaluation of new methyloxiranylmethoxyxanthone analogues. |
| AID1401028 | Antiproliferative activity against human MDA-MB-231 cells after 96 hrs by MTT assay | 2017 | European journal of medicinal chemistry, Dec-01, Volume: 141 | Synthesis, anticancer evaluation and pharmacokinetic study of novel 10-O-phenyl ethers of dihydroartemisinin. |
| AID478260 | Cytotoxicity against human topotecan-resistant MCF7 cells after 48 hrs by MTT assay | 2010 | European journal of medicinal chemistry, May, Volume: 45, Issue:5
| Modulation of doxorubicin activity in cancer cells by conjugation with fatty acyl and terpenyl hydrazones. |
| AID1887104 | Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability by SRB assay | | | |
| AID55638 | Change in thermal denaturation temperature of calf thymus DNA | 1984 | Journal of medicinal chemistry, May, Volume: 27, Issue:5
| Intensely potent morpholinyl anthracyclines. |
| AID1430414 | Cytotoxicity against human HeLa cells assessed as cell growth at 10'-4 M after 48 hrs by SRB assay relative to control | 2017 | Bioorganic & medicinal chemistry letters, 03-01, Volume: 27, Issue:5
| Methylsulfonyl benzothiazoles (MSBT) derivatives: Search for new potential antimicrobial and anticancer agents. |
| AID461179 | Antitumor activity against human MOLT4F cells | 2010 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 20, Issue:3
| Polar 3-alkylidene-5-pivaloyloxymethyl-5'-hydroxymethyl-gamma-lactones as protein kinase C ligands and antitumor agents. |
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| Discovery of thiosemicarbazone-containing compounds with potent anti-proliferation activity against drug-resistant K562/A02 cells. |
| AID1524521 | Antiproliferative activity against human MDA-MB-231 cells measured after 48 hrs by MTT assay | | | |
| AID1699970 | Antiproliferative activity against human K562/A02 cells overexpressing P-gp by MTT assay | 2020 | Bioorganic & medicinal chemistry letters, 12-15, Volume: 30, Issue:24
| Discovery of thiosemicarbazone-containing compounds with potent anti-proliferation activity against drug-resistant K562/A02 cells. |
| AID478254 | Cytotoxicity against human HL60 cells after 48 hrs by MTT assay | 2010 | European journal of medicinal chemistry, May, Volume: 45, Issue:5
| Modulation of doxorubicin activity in cancer cells by conjugation with fatty acyl and terpenyl hydrazones. |
| AID1671762 | Inhibition of epithelial-mesenchymal transition in human SMMC-7721 cells assessed as increase in TGF-beta1 reduced E-cadherin expression at 0.5 uM incubated for 48 hrs by Immunofluorescence staining based laser-scanning confocal microscope | 2019 | European journal of medicinal chemistry, Mar-15, Volume: 166 | Excellent antitumor and antimetastatic activities based on novel coumarin/pyrazole oxime hybrids. |
| AID1625417 | Cytotoxicity against human SMMC7721 cells assessed as reduction in cell viability by MTT assay | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4
| Bafilomycins and Odoriferous Sesquiterpenoids from Streptomyces albolongus Isolated from Elephas maximus Feces. |
| AID423397 | Cytotoxicity against human K562 cells after 48 hrs by MTT assay | 2009 | Journal of natural products, Apr, Volume: 72, Issue:4
| Bioactive alkaloids from endophytic Aspergillus fumigatus. |
| AID1426697 | Toxicity in BALB/c nude mouse administered via ip for every 3 days of four injections | 2017 | Journal of medicinal chemistry, 02-09, Volume: 60, Issue:3
| Potent Inhibition of Nitric Oxide-Releasing Bifendate Derivatives against Drug-Resistant K562/A02 Cells in Vitro and in Vivo. |
| AID1617193 | Cytotoxicity against human NCI-H23 cells assessed as cell growth inhibition measured after 48 hrs by SRB assay | 2019 | Journal of natural products, 11-22, Volume: 82, Issue:11
| Resorcinosides A and B, Glycosylated Alkylresorcinols from a Marine-Derived Strain of the Fungus |
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| AID1400964 | Antiproliferative activity in human MCF7 cells after 48 hrs by MTT assay | 2017 | European journal of medicinal chemistry, Aug-18, Volume: 136 | Design, synthesis and biological evaluation of nitrogen-containing macrocyclic bisbibenzyl derivatives as potent anticancer agents by targeting the lysosome. |
| AID512238 | Anticancer activity against human ZR-75-1 cells after 48 hrs by SRB assay | 2010 | European journal of medicinal chemistry, Sep, Volume: 45, Issue:9
| Design, synthesis and biological evaluation of 3,5-diaryl-isoxazoline/isoxazole-pyrrolobenzodiazepine conjugates as potential anticancer agents. |
| AID1435316 | Binding affinity to calf thymus duplex DNA by fluorescence spectroscopic method | 2017 | ACS medicinal chemistry letters, Mar-09, Volume: 8, Issue:3
| Light-Regulated NO Release as a Novel Strategy To Overcome Doxorubicin Multidrug Resistance. |
| AID1887847 | Resistance index, ratio of IC50 for antiproliferative activity against adriamycin resistant human MCF7/ADR cells to IC50 for antiproliferative activity against human MCF7 cells | 2022 | European journal of medicinal chemistry, Jan-05, Volume: 227 | Structure modification and biological evaluation of indole-chalcone derivatives as anti-tumor agents through dual targeting tubulin and TrxR. |
| AID512019 | Cytotoxicity against human HOP62 cells after 48 hrs by SRB assay | 2010 | European journal of medicinal chemistry, Sep, Volume: 45, Issue:9
| Synthesis and biological evaluation of cinnamido linked pyrrolo[2,1-c][1,4]benzodiazepines as antimitotic agents. |
| AID1132918 | In vivo antitumor activity against mouse P388 cells allografted in BDF/CDF mouse assessed as host survival time at 0.25 mg/kg, ip administered on days 1 to 9 relative to control | 1978 | Journal of medicinal chemistry, Aug, Volume: 21, Issue:8
| Antitumor anthracycline antibiotics. Structure-activity and structure-cardiotoxicity relationships of rubidazone analogues. |
| AID1308402 | Cytotoxicity in human U2OS/DX30 cells at 5 uM incubated for 24 hrs by LDH release-based spectrofluorimetrical analysis | 2016 | Journal of medicinal chemistry, 05-26, Volume: 59, Issue:10
| H2S-Donating Doxorubicins May Overcome Cardiotoxicity and Multidrug Resistance. |
| AID1671737 | Antiproliferative activity against human U87 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay | 2019 | European journal of medicinal chemistry, Mar-15, Volume: 166 | Excellent antitumor and antimetastatic activities based on novel coumarin/pyrazole oxime hybrids. |
| AID1762049 | Cytotoxicity against human HepG2 cells assessed as inhibition of cell proliferation after 72 hrs by MTT assay | 2021 | Bioorganic & medicinal chemistry letters, 05-15, Volume: 40 | One pot synthesis, in silico study and evaluation of some novel flavonoids as potent topoisomerase II inhibitors. |
| AID478103 | Cytotoxicity against human MCF7 cells after 45 hrs by resazurin microplate assay | 2010 | Journal of natural products, Apr-23, Volume: 73, Issue:4
| Hopane-type triterpenes and binaphthopyrones from the scale insect pathogenic fungus Aschersonia paraphysata BCC 11964. |
| AID1168505 | Cytotoxicity against human HepG2 cells by MTT assay | 2014 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 24, Issue:22
| Synthesis and biological evaluation of a novel class of coumarin derivatives. |
| AID1517673 | Antiproliferative activity against human Bel7402 incubated for 72 hrs by MTT assay | 2019 | European journal of medicinal chemistry, Dec-01, Volume: 183 | Design and synthesis of parthenolide and 5-fluorouracil conjugates as potential anticancer agents against drug resistant hepatocellular carcinoma. |
| AID1612617 | Antiproliferative activity against human A549 cells after 72 hrs by MTT assay | 2019 | European journal of medicinal chemistry, Feb-01, Volume: 163 | Design, synthesis and biological evaluation of quinoline-indole derivatives as anti-tubulin agents targeting the colchicine binding site. |
| AID619897 | Cytotoxicity against human OS-RC2 cells by MTT assay | 2011 | European journal of medicinal chemistry, Oct, Volume: 46, Issue:10
| Synthesis and biological evaluation of 1,9-disubstituted β-carbolines as potent DNA intercalating and cytotoxic agents. |
| AID1625739 | Cytotoxicity against P-gp overexpressing human MCF7/ADR cells assessed as reduction in cell growth after 24 hrs by MTT assay | 2016 | Journal of medicinal chemistry, 06-23, Volume: 59, Issue:12
| Design, Synthesis, and Evaluation of in Vitro and in Vivo Anticancer Activity of 4-Substituted Coumarins: A Novel Class of Potent Tubulin Polymerization Inhibitors. |
| AID1327572 | Cytotoxicity against human HL60 cells after 48 hrs by MTT assay | 2016 | Journal of natural products, 08-26, Volume: 79, Issue:8
| Rhizovarins A-F, Indole-Diterpenes from the Mangrove-Derived Endophytic Fungus Mucor irregularis QEN-189. |
| AID1441125 | Cytotoxicity against cancer stem cells derived from human BT474 cells assessed as cancer stem cell death at 20 uM after 3 days by MTS assay | 2017 | Journal of medicinal chemistry, 03-09, Volume: 60, Issue:5
| Replacing d-Glucosamine with Its l-Enantiomer in Glycosylated Antitumor Ether Lipids (GAELs) Retains Cytotoxic Effects against Epithelial Cancer Cells and Cancer Stem Cells. |
| AID1185753 | Cytotoxicity against human KG1 cells after 48 hrs by Alamar blue assay | 2014 | European journal of medicinal chemistry, 09-12, Volume: 84 | Synthesis and evaluation of the cytotoxic activity of 1,2-furanonaphthoquinones tethered to 1,2,3-1H-triazoles in myeloid and lymphoid leukemia cell lines. |
| AID1441129 | Cytotoxicity against human JIMT1 cells assessed as decrease in cell viability up to 8 uM after 48 hrs in absence of pan-caspase inhibitor QVD-OPh by MTS assay | 2017 | Journal of medicinal chemistry, 03-09, Volume: 60, Issue:5
| Replacing d-Glucosamine with Its l-Enantiomer in Glycosylated Antitumor Ether Lipids (GAELs) Retains Cytotoxic Effects against Epithelial Cancer Cells and Cancer Stem Cells. |
| AID1625726 | Antiproliferative activity against human A2780S cells after 24 hrs by MTT assay | 2016 | Journal of medicinal chemistry, 06-23, Volume: 59, Issue:12
| Design, Synthesis, and Evaluation of in Vitro and in Vivo Anticancer Activity of 4-Substituted Coumarins: A Novel Class of Potent Tubulin Polymerization Inhibitors. |
| AID462327 | Cytotoxicity against human HeLa cells in presence of 10% fetal bovine serum | 2010 | Bioorganic & medicinal chemistry, Mar-15, Volume: 18, Issue:6
| Synthesis of 2-(thienyl-2-yl or -3-yl)-4-furyl-6-aryl pyridine derivatives and evaluation of their topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship. |
| AID1657548 | Cytotoxicity against human A549 cells after 72 hrs by MTT assay | | | |
| AID97978 | Dose required to inhibit the DNA synthesis in leukemia L1210 cells | 1981 | Journal of medicinal chemistry, Jun, Volume: 24, Issue:6
| Synthesis and preliminary antitumor evaluation of 5-iminodoxorubicin. |
| AID1890792 | Cytotoxicity against human HCT-15 cells assessed as cell growth inhibition incubated for 48 hrs by SRB method | 2022 | Journal of natural products, 04-22, Volume: 85, Issue:4
| Isolation, Structure Determination, and Semisynthesis of Diphenazine Compounds from a Deep-Sea-Derived Strain of the Fungus |
| AID1358360 | Inhibition of ALDH in human PANC1 cells assessed as aldefluor positive cells at 0.5 uM after 72 hrs in presence of DEAB by aldefluor assay (Rvb = 0.455%) | 2018 | European journal of medicinal chemistry, May-10, Volume: 151 | Syntheses and anti-pancreatic cancer activities of rakicidin A analogues. |
| AID592929 | Cytotoxicity against human HOP62 cells by sulforhodamine B method | 2011 | Bioorganic & medicinal chemistry, Apr-15, Volume: 19, Issue:8
| Synthesis and biological evaluation of estradiol linked pyrrolo[2,1-c][1,4]benzodiazepine (PBD) conjugates as potential anticancer agents. |
| AID1817884 | Antiproliferative activity against human HCT-15 cells assessed as reduction in cell viability after 48 hrs by by Ez-cytoX based microplate reader method | 2021 | European journal of medicinal chemistry, Dec-15, Volume: 226 | Discovery of a 2,4-diphenyl-5,6-dihydrobenzo(h)quinolin-8-amine derivative as a novel DNA intercalating topoisomerase IIα poison. |
| AID1612618 | Antiproliferative activity against human Bel7402 cells after 72 hrs by MTT assay | 2019 | European journal of medicinal chemistry, Feb-01, Volume: 163 | Design, synthesis and biological evaluation of quinoline-indole derivatives as anti-tubulin agents targeting the colchicine binding site. |
| AID1489123 | Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 24 hrs by CCK-8 assay | 2017 | Bioorganic & medicinal chemistry letters, 09-01, Volume: 27, Issue:17
| Discovery of novel 4(1H)-quinolone derivatives as potential antiproliferative and apoptosis inducing agents. |
| AID621713 | Antiproliferative activity against human A549 cells by MTT assay in presence of human serum transferrin/apo transferrin | 2011 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 21, Issue:19
| Constructing transferrin receptor targeted drug delivery system by using doxorubicin hydrochloride and vanadocene dichloride. |
| AID1486764 | Antiproliferative activity against human T47D cells after 72 hrs by CCK8 assay | 2017 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 27, Issue:15
| 2-Chlorophenyl-substituted benzofuro[3,2-b]pyridines with enhanced topoisomerase inhibitory activity: The role of the chlorine substituent. |
| AID734088 | Growth inhibition against human K562 cells after 72 hrs by inverted microscopy | 2013 | European journal of medicinal chemistry, Apr, Volume: 62 | Synthesis, cytotoxicity and antiplasmodial activity of novel ent-kaurane derivatives. |
| AID1435305 | Cytotoxicity against 7 mW/cm'2 irradiated human M14 cells assessed as increase in LDH release at 5 uM measured after 20 mins by spectrophotometric method | 2017 | ACS medicinal chemistry letters, Mar-09, Volume: 8, Issue:3
| Light-Regulated NO Release as a Novel Strategy To Overcome Doxorubicin Multidrug Resistance. |
| AID1331840 | Cytotoxicity against human MRC9 cells assessed as cell growth inhibition after 48 hrs by SRB assay | 2016 | Journal of natural products, 09-23, Volume: 79, Issue:9
| Isolation of Coralmycins A and B, Potent Anti-Gram Negative Compounds from the Myxobacteria Corallococcus coralloides M23. |
| AID1882748 | Anticancer activity against human SGC-7901 cells assessed as inhibition of cell proliferation incubated for 48 hrs by MTT assay | 2022 | European journal of medicinal chemistry, May-05, Volume: 235 | Recent advances of antitumor shikonin/alkannin derivatives: A comprehensive overview focusing on structural classification, synthetic approaches, and mechanisms of action. |
| AID1308417 | Drug uptake in human U2OS/DX580 cells at 5 uM incubated for 24 hrs by fluorimetrical analysis | 2016 | Journal of medicinal chemistry, 05-26, Volume: 59, Issue:10
| H2S-Donating Doxorubicins May Overcome Cardiotoxicity and Multidrug Resistance. |
| AID1612624 | Drug resistance index, ratio of IC50 for VCR-resistant human K562/VCR cells to IC50 for human K562 cells | 2019 | European journal of medicinal chemistry, Feb-01, Volume: 163 | Design, synthesis and biological evaluation of quinoline-indole derivatives as anti-tubulin agents targeting the colchicine binding site. |
| AID1525110 | Cytotoxicity against human SMMC7721 cells assessed as reduction in cell viability by MTT assay | 2019 | Journal of natural products, 05-24, Volume: 82, Issue:5
| Strepantibins A-C: Hexokinase II Inhibitors from a Mud Dauber Wasp Associated Streptomyces sp. |
| AID1541625 | Cytotoxicity against human HepG2 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay | 2019 | Journal of natural products, 12-27, Volume: 82, Issue:12
| Glucoconjugated Monoterpene Indole Alkaloids from |
| AID122110 | Antitumor activity against mice baering P388 leukemia (10e6 cells) implanted ip on day 0, after treatment with three ip doses (8 mg/kg) on day 5,9,13 when tumor became systemic. | 1984 | Journal of medicinal chemistry, May, Volume: 27, Issue:5
| Intensely potent morpholinyl anthracyclines. |
| AID1508149 | Cytotoxicity against human MCF7 cells assessed as growth inhibition after 48 hrs by MTT assay | 2017 | European journal of medicinal chemistry, Oct-20, Volume: 139 | Design, synthesis and biological evaluation of novel pyrazolochalcones as potential modulators of PI3K/Akt/mTOR pathway and inducers of apoptosis in breast cancer cells. |
| AID1430415 | Growth inhibition of human HeLa cells after 48 hrs by SRB assay | 2017 | Bioorganic & medicinal chemistry letters, 03-01, Volume: 27, Issue:5
| Methylsulfonyl benzothiazoles (MSBT) derivatives: Search for new potential antimicrobial and anticancer agents. |
| AID1583362 | Antiproliferative activity against rat C6 cells assessed as reduction in cell viability after 72 hrs by MTT assay | 2020 | Journal of medicinal chemistry, 02-27, Volume: 63, Issue:4
| Identification of Parthenolide Dimers as Activators of Pyruvate Kinase M2 in Xenografts of Glioblastoma Multiforme in Vivo. |
| AID1594720 | Cytotoxicity against human A549 cells measured after 72 hrs by CCK8 assay | 2019 | Journal of natural products, 06-28, Volume: 82, Issue:6
| Cytotoxic Tigliane Diterpenoids from Croton damayeshu. |
| AID1508154 | Cell cycle arrest in human MCF7 cells assessed as accumulation at G0/G1 phase at 2 uM after 24 hrs by flow cytometric analysis (Rvb = 18.4%) | 2017 | European journal of medicinal chemistry, Oct-20, Volume: 139 | Design, synthesis and biological evaluation of novel pyrazolochalcones as potential modulators of PI3K/Akt/mTOR pathway and inducers of apoptosis in breast cancer cells. |
| AID613198 | Antitumor activity against human A549 cells after 72 hrs by SRB assay | 2011 | Journal of natural products, Jul-22, Volume: 74, Issue:7
| Antitumor actinopyranones produced by Streptomyces albus POR-04-15-053 isolated from a marine sediment. |
| AID1546807 | Cytotoxicity against human A549 cells after 24 hrs by SRB method | 2020 | Journal of natural products, 01-24, Volume: 83, Issue:1
| Prenylated |
| AID1821807 | Selectivity index, ratio of IC50 for antiproliferative activity against human MCF-10A cells to IC50 for antiproliferative activity against human MDA-MB-231 cells by MTT assay | 2022 | European journal of medicinal chemistry, Feb-05, Volume: 229 | Design and synthesis of marine sesterterpene analogues as novel estrogen receptor α degraders for breast cancer treatment. |
| AID1132914 | In vivo antitumor activity against mouse P388 cells allografted in BDF/CDF mouse assessed as host survival time at 4 mg/kg, ip administered on days 1 to 9 relative to control | 1978 | Journal of medicinal chemistry, Aug, Volume: 21, Issue:8
| Antitumor anthracycline antibiotics. Structure-activity and structure-cardiotoxicity relationships of rubidazone analogues. |
| AID1684108 | Cytotoxicity against human A549 cells assessed as reduction in cell viability after 72 hrs by MTT assay | | | |
| AID1435966 | Cytotoxicity against human HepG2 cells assessed as growth inhibition at 10 uM measured after 72 hrs by CCK-8 assay relative to control | | | |
| AID650185 | Cytotoxicity against human MGC803 cells after 48 hrs by MTT assay | 2012 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 22, Issue:5
| Synthesis and evaluation of cytotoxic effects of novel α-methylenelactone tetracyclic diterpenoids. |
| AID1337473 | Antiproliferative activity against human HCT15 cells after 72 hrs by CCK8 assay | 2017 | European journal of medicinal chemistry, Jan-05, Volume: 125 | Novel 2-aryl-4-(4'-hydroxyphenyl)-5H-indeno[1,2-b]pyridines as potent DNA non-intercalative topoisomerase catalytic inhibitors. |
| AID1498580 | Growth inhibition of human MDA-MB-231/ADR cells after 48 hrs by MTT assay | 2018 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 28, Issue:14
| The inhibitory effect of kokusaginine on the growth of human breast cancer cells and MDR-resistant cells is mediated by the inhibition of tubulin assembly. |
| AID1672167 | Cytotoxicity against human HL60 cells assessed as inhibition of cell proliferation after 48 hrs by MTT assay | 2019 | Bioorganic & medicinal chemistry, 04-01, Volume: 27, Issue:7
| Design and synthesis of various quinizarin derivatives as potential anticancer agents in acute T lymphoblastic leukemia. |
| AID480110 | Cytotoxicity against human HCT15 cells after 2 days by automatic ELISA reader system | 2010 | Bioorganic & medicinal chemistry, May-01, Volume: 18, Issue:9
| Synthesis, topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship study of hydroxylated 2,4-diphenyl-6-aryl pyridines. |
| AID595892 | Cytotoxicity against human KB cells after 45 hrs by resazurin microplate assay | 2011 | Journal of natural products, Apr-25, Volume: 74, Issue:4
| Bioactive compounds from the scale insect pathogenic fungus Conoideocrella tenuis BCC 18627. |
| AID1821803 | Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability after 48 hrs by MTT assay | 2022 | European journal of medicinal chemistry, Feb-05, Volume: 229 | Design and synthesis of marine sesterterpene analogues as novel estrogen receptor α degraders for breast cancer treatment. |
| AID1428411 | Cytotoxicity against multidrug resistant human MCF7 cells cultured in vinblastine containing medium assessed as growth inhibition after 72 hrs by SRB assay | | | |
| AID1505072 | Cytotoxicity against human MDA-MB-231 cells after 72 hrs by MTT assay | 2018 | Journal of natural products, 01-26, Volume: 81, Issue:1
| Ophiobolins from the Mangrove Fungus Aspergillus ustus. |
| AID1880231 | Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth incubated for 48 hrs by CCK8 assay | 2022 | ACS medicinal chemistry letters, May-12, Volume: 13, Issue:5
| Synthesis and Antitumor Activity of Diosgenin Hydroxamic Acid and Quaternary Phosphonium Salt Derivatives. |
| AID1288333 | Antiproliferative activity against human BT474 cells after 72 hrs by CCK8 assay | 2016 | Bioorganic & medicinal chemistry, Apr-15, Volume: 24, Issue:8
| Design, synthesis, topoisomerase I & II inhibitory activity, antiproliferative activity, and structure-activity relationship study of pyrazoline derivatives: An ATP-competitive human topoisomerase IIα catalytic inhibitor. |
| AID1185514 | Cytotoxicity against HEK293 cells after 4 days by CCK-8 assay | 2014 | European journal of medicinal chemistry, Sep-12, Volume: 84 | Synthesis, antitumor activity, and structure-activity relationship study of trihydroxylated 2,4,6-triphenyl pyridines as potent and selective topoisomerase II inhibitors. |
| AID1288621 | Cytotoxicity against human K562/A02 cells assessed as cell viability after 48 hrs by MTT assay | 2016 | Bioorganic & medicinal chemistry, 05-15, Volume: 24, Issue:10
| Design, synthesis and biological evaluation of LBM-A5 derivatives as potent P-glycoprotein-mediated multidrug resistance inhibitors. |
| AID246830 | In vitro cytotoxicity against Leukemia L1210 cell line | 2005 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 15, Issue:15
| A macromolecular prodrug of doxorubicin conjugated to a biodegradable cyclotriphosphazene bearing a tetrapeptide. |
| AID490287 | Antiproliferative activity against mouse r/m HM-SFME-1 cells after 24 hrs by MTT assay | 2010 | European journal of medicinal chemistry, Jul, Volume: 45, Issue:7
| Novel effects of glycyrrhetinic acid on the central nervous system tumorigenic progenitor cells: induction of actin disruption and tumor cell-selective toxicity. |
| AID621710 | Binding affinity to human apo transferrin after 12 hrs at pH 7.4 by spectrofluorometer method | 2011 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 21, Issue:19
| Constructing transferrin receptor targeted drug delivery system by using doxorubicin hydrochloride and vanadocene dichloride. |
| AID613197 | Antitumor activity against human HT-29 cells after 72 hrs by SRB assay | 2011 | Journal of natural products, Jul-22, Volume: 74, Issue:7
| Antitumor actinopyranones produced by Streptomyces albus POR-04-15-053 isolated from a marine sediment. |
| AID1278414 | Cytotoxicity against human K562 cells after 72 hrs by MTT assay | 2016 | Bioorganic & medicinal chemistry letters, Feb-15, Volume: 26, Issue:4
| Dispirocyclopropyldehydrocostus lactone selectively inhibits acute myelogenous leukemia cells. |
| AID1583361 | Antiproliferative activity against human U251 cells assessed as reduction in cell viability after 72 hrs by MTT assay | 2020 | Journal of medicinal chemistry, 02-27, Volume: 63, Issue:4
| Identification of Parthenolide Dimers as Activators of Pyruvate Kinase M2 in Xenografts of Glioblastoma Multiforme in Vivo. |
| AID462328 | Cytotoxicity against human DU145 cells in presence of 10% fetal bovine serum | 2010 | Bioorganic & medicinal chemistry, Mar-15, Volume: 18, Issue:6
| Synthesis of 2-(thienyl-2-yl or -3-yl)-4-furyl-6-aryl pyridine derivatives and evaluation of their topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship. |
| AID1264615 | Cytotoxicity against human NCI-H1975 cells after 72 hrs by MTT assay | 2015 | Journal of natural products, Nov-25, Volume: 78, Issue:11
| Versixanthones A-F, Cytotoxic Xanthone-Chromanone Dimers from the Marine-Derived Fungus Aspergillus versicolor HDN1009. |
| AID494501 | Antiproliferative activity against human K562 cells after 48 hrs | 2010 | European journal of medicinal chemistry, Aug, Volume: 45, Issue:8
| Synthesis, antiproliferative activity and inhibition of tubulin polymerization by 1,5- and 1,8-disubstituted 10H-anthracen-9-ones bearing a 10-benzylidene or 10-(2-oxo-2-phenylethylidene) moiety. |
| AID1888032 | Antiproliferative activity against human DU-145 cells after 72 hrs by EZ-Cytox colorimetric assay | 2022 | European journal of medicinal chemistry, Jan-05, Volume: 227 | Identification of new halogen-containing 2,4-diphenyl indenopyridin-5-one derivative as a boosting agent for the anticancer responses of clinically available topoisomerase inhibitors. |
| AID1768121 | Cytotoxicity against human A549 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay | 2021 | Journal of natural products, 07-23, Volume: 84, Issue:7
| Iridoid Constituents of |
| AID1901893 | Antiproliferative activity against human A549 cells assessed as reduction in cell viability after 72 hrs by CCK-8 assay | 2022 | Bioorganic & medicinal chemistry, 03-01, Volume: 57 | Cathepsin D inhibitors based on tasiamide B derivatives with cell membrane permeability. |
| AID1783251 | Cytotoxicity against human HepG2 cells assessed as inhibition of proliferation incubated for 72 hrs by MTT assay | | | |
| AID549507 | Cytotoxicity against human HeLa cells after 48 hrs by MTT assay | 2011 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 21, Issue:1
| Efficient synthesis and biological evaluation of epiceanothic acid and related compounds. |
| AID461391 | Antitumor activity against human NCI-H322 cells | 2010 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 20, Issue:3
| Polar 3-alkylidene-5-pivaloyloxymethyl-5'-hydroxymethyl-gamma-lactones as protein kinase C ligands and antitumor agents. |
| AID1491056 | Cytotoxicity against human A549 cells assessed as reduction in cell viability after 72 hrs by MTT assay | 2017 | Journal of natural products, 05-26, Volume: 80, Issue:5
| Inflammation Modulatory Phorbol Esters from the Seeds of Aquilaria malaccensis. |
| AID1905057 | Resistance index, ratio of IC50 for antiproliferative activity against human adriamycin-resistant A549/ADR cells to IC50 for antiproliferative activity against human A549 cells | 2022 | Journal of medicinal chemistry, 03-24, Volume: 65, Issue:6
| Discovery of a Novel Stilbene Derivative as a Microtubule Targeting Agent Capable of Inducing Cell Ferroptosis. |
| AID1490961 | Cytotoxicity against human A549 cells after 24 hrs by sulforhodamine B assay | 2017 | Journal of natural products, 05-26, Volume: 80, Issue:5
| Geranylpyrrol A and Piericidin F from Streptomyces sp. CHQ-64 ΔrdmF. |
| AID1318676 | Cytotoxicity against human MCF7 cells assessed as inhibition of cell survival rate after 48 hrs by MTT assay | 2016 | European journal of medicinal chemistry, Oct-04, Volume: 121 | neo-Clerodane diterpenoids from Scutellaria barbata mediated inhibition of P-glycoprotein in MCF-7/ADR cells. |
| AID1320986 | Cytotoxicity against human HT-29 cells assessed as decrease in cell viability after 48 hrs by MTT assay | 2016 | European journal of medicinal chemistry, Oct-04, Volume: 121 | Design, synthesis and biological evaluation of novel macrocyclic bisbibenzyl analogues as tubulin polymerization inhibitors. |
| AID592699 | Cytotoxicity against human A2780 cells after 48 hrs by sulforhodamine B based ELISA | 2011 | Bioorganic & medicinal chemistry, Apr-01, Volume: 19, Issue:7
| Synthesis of a new 4-aza-2,3-didehydropodophyllotoxin analogues as potent cytotoxic and antimitotic agents. |
| AID1625740 | Resistance index, ratio of IC50 for P-gp overexpressing human MCF7/ADR cells to IC50 for human MCF7 cells | 2016 | Journal of medicinal chemistry, 06-23, Volume: 59, Issue:12
| Design, Synthesis, and Evaluation of in Vitro and in Vivo Anticancer Activity of 4-Substituted Coumarins: A Novel Class of Potent Tubulin Polymerization Inhibitors. |
| AID1390168 | Antiproliferative activity against human HCT15 cells after 72 hrs by CCK-8 assay | 2018 | Bioorganic & medicinal chemistry, 05-01, Volume: 26, Issue:8
| Synthesis and SAR study of new hydroxy and chloro-substituted 2,4-diphenyl 5H-chromeno[4,3-b]pyridines as selective topoisomerase IIα-targeting anticancer agents. |
| AID592421 | Cytotoxicity against human A549 cells assessed as inhibition of cell proliferation after 72 hrs by SRB assay | 2011 | Journal of natural products, Mar-25, Volume: 74, Issue:3
| Trigonosins A-F, daphnane diterpenoids from Trigonostemon thyrsoideum. |
| AID490207 | Cytotoxicity against human OS-RC2 cells by MTT assay | 2010 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 20, Issue:13
| Synthesis of novel beta-carbolines with efficient DNA-binding capacity and potent cytotoxicity. |
| AID1278415 | Cytotoxicity against human K562/A02 cells after 72 hrs by MTT assay | 2016 | Bioorganic & medicinal chemistry letters, Feb-15, Volume: 26, Issue:4
| Dispirocyclopropyldehydrocostus lactone selectively inhibits acute myelogenous leukemia cells. |
| AID1126868 | Cytotoxicity against human MCF7 cells assessed as growth inhibition after 72 hrs by SRB assay | 2014 | European journal of medicinal chemistry, May-06, Volume: 78 | Searching for new derivatives of neocryptolepine: synthesis, antiproliferative, antimicrobial and antifungal activities. |
| AID1594689 | Cytotoxicity in human U251 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay | 2019 | Journal of natural products, 06-28, Volume: 82, Issue:6
| Asperunguisins A-F, Cytotoxic Asperane Sesterterpenoids from the Endolichenic Fungus Aspergillus unguis. |
| AID478307 | Cytotoxicity against human HL60 cells assessed as increase in ROS production at 5 uM after 24 hrs by NBT reduction assay relative to control | 2010 | European journal of medicinal chemistry, May, Volume: 45, Issue:5
| Modulation of doxorubicin activity in cancer cells by conjugation with fatty acyl and terpenyl hydrazones. |
| AID1546803 | Cytotoxicity against human L02 cells after 24 hrs by SRB method | 2020 | Journal of natural products, 01-24, Volume: 83, Issue:1
| Prenylated |
| AID1543248 | Cytotoxicity in human SW620 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay | 2019 | Journal of natural products, 07-26, Volume: 82, Issue:7
| Prenylated Bibenzyls from the Chinese Liverwort |
| AID456252 | Cytotoxicity against human DU145 cells after 4 days by ELISA reader assay | 2010 | Bioorganic & medicinal chemistry, Jan-01, Volume: 18, Issue:1
| 2-Thienyl-4-furyl-6-aryl pyridine derivatives: synthesis, topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship study. |
| AID619819 | Cytotoxicity against human 786-0 cells by MTT assay | 2011 | European journal of medicinal chemistry, Oct, Volume: 46, Issue:10
| Synthesis and biological evaluation of 1,9-disubstituted β-carbolines as potent DNA intercalating and cytotoxic agents. |
| AID1491062 | Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 72 hrs by MTT assay | 2017 | Journal of natural products, 05-26, Volume: 80, Issue:5
| Inflammation Modulatory Phorbol Esters from the Seeds of Aquilaria malaccensis. |
| AID1075858 | Cytotoxicity against mouse B16F10 cells assessed as growth inhibition by SRB assay | 2014 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 24, Issue:5
| Further constituents of Galianthe thalictroides (Rubiaceae) and inhibition of DNA topoisomerases I and IIα by its cytotoxic β-carboline alkaloids. |
| AID1478726 | Antiproliferative activity against human T47D cells after 72 hrs by CCK8 assay | 2017 | European journal of medicinal chemistry, Jun-16, Volume: 133 | Dihydroxylated 2,6-diphenyl-4-chlorophenylpyridines: Topoisomerase I and IIα dual inhibitors with DNA non-intercalative catalytic activity. |
| AID1421551 | Antiproliferative activity against human HepG2 cells assessed as inhibition of cell growth at 1 uM after 72 hrs by sulforhodamine B assay relative to control | 2018 | European journal of medicinal chemistry, Oct-05, Volume: 158 | Four new antitumor metabolites isolated from a mutant 3-f-31 strain derived from Penicillium purpurogenum G59. |
| AID103703 | Cytotoxicity against MCF-7 cell line in the purdue cell culture screen was determined | 1999 | Bioorganic & medicinal chemistry letters, Feb-08, Volume: 9, Issue:3
| On the relationship of OSW-1 to the cephalostatins. |
| AID138192 | Compound was evaluated for antitumor activity in mice injected intraperitoneal with leukemia P-388 cells, treated on days 5, 9, and 13 th day at 4 mg/kg | 1981 | Journal of medicinal chemistry, Jun, Volume: 24, Issue:6
| Synthesis and preliminary antitumor evaluation of 5-iminodoxorubicin. |
| AID618833 | Cytotoxicity against human HeLa cells after 2 days by MTT assay | 2011 | European journal of medicinal chemistry, Sep, Volume: 46, Issue:9
| Synthesis of 4β-triazole-podophyllotoxin derivatives by azide-alkyne cycloaddition and biological evaluation as potential antitumor agents. |
| AID1489127 | Cytotoxicity against human HeLa cells assessed as reduction in cell viability after 24 hrs by CCK-8 assay | 2017 | Bioorganic & medicinal chemistry letters, 09-01, Volume: 27, Issue:17
| Discovery of novel 4(1H)-quinolone derivatives as potential antiproliferative and apoptosis inducing agents. |
| AID1326553 | Antiproliferative activity against human MDA-MB-231 cells measured after 48 hrs by MTT assay | 2016 | European journal of medicinal chemistry, Oct-21, Volume: 122 | Discovery and development of natural product oridonin-inspired anticancer agents. |
| AID1882809 | Anticancer activity against mouse L1210 cells assessed as reduction in cell viability for 72 hrs by MTT assay | 2022 | European journal of medicinal chemistry, May-05, Volume: 235 | Recent advances of antitumor shikonin/alkannin derivatives: A comprehensive overview focusing on structural classification, synthetic approaches, and mechanisms of action. |
| AID1577566 | Antiproliferative activity against human NCI-H226 cells assessed as reduction in cell viability after 24 hrs by CCK8 assay | | | |
| AID1611345 | Binding affinity to human serum albumin assessed as binding constant after 24 hrs by absorption spectroscopy | 2019 | Bioorganic & medicinal chemistry, 12-15, Volume: 27, Issue:24
| Dual mode of binding of anti cancer drug epirubicin to G-quadruplex [d-(TTAGGGT)] |
| AID1462353 | Cytotoxicity against African green monkey Vero cells after 72 hrs by sulforhodamine B assay | | | |
| AID696200 | Inhibition of CDDP-induced FANCD2 monoubiquitination in human HeLa cells at 9 uM after 18 hrs by Western blot analysis | 2012 | Bioorganic & medicinal chemistry, Nov-01, Volume: 20, Issue:21
| The antitumor agent doxorubicin binds to Fanconi anemia group F protein. |
| AID1546809 | Cytotoxicity against human HeLa cells after 24 hrs by SRB method | 2020 | Journal of natural products, 01-24, Volume: 83, Issue:1
| Prenylated |
| AID86074 | Cytotoxicity against HT-29 cell line in the purdue cell culture screen was determined | 1999 | Bioorganic & medicinal chemistry letters, Feb-08, Volume: 9, Issue:3
| On the relationship of OSW-1 to the cephalostatins. |
| AID1421557 | Antiproliferative activity against human HT-29 cells assessed as inhibition of cell growth at 1 uM after 72 hrs by sulforhodamine B assay relative to control | 2018 | European journal of medicinal chemistry, Oct-05, Volume: 158 | Four new antitumor metabolites isolated from a mutant 3-f-31 strain derived from Penicillium purpurogenum G59. |
| AID580234 | Cytotoxicity against human SW1116 cells assessed as cell proliferation inhibition rate at 10 ug/ml after 24 hrs by MTT assay | 2011 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 21, Issue:5
| Substrate-controlled chemoselective synthesis and potent cytotoxic activity of novel 5,6,7-triarylpyrido[2,3-d]pyrimidin-4-one derivatives. |
| AID462330 | Cytotoxicity against human K562 cells in presence of 10% fetal bovine serum | 2010 | Bioorganic & medicinal chemistry, Mar-15, Volume: 18, Issue:6
| Synthesis of 2-(thienyl-2-yl or -3-yl)-4-furyl-6-aryl pyridine derivatives and evaluation of their topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship. |
| AID1168508 | Cytotoxicity against human Bel7402 cells by MTT assay | 2014 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 24, Issue:22
| Synthesis and biological evaluation of a novel class of coumarin derivatives. |
| AID1706711 | Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability by MTT assay | 2021 | European journal of medicinal chemistry, Jan-01, Volume: 209 | Discovery of lysosome-targeted covalent anticancer agents based on isosteviol skeleton. |
| AID1481490 | Cytotoxicity against human K562/A02 cells overexpressing P-gp after 48 hrs by MTT assay | 2017 | Journal of medicinal chemistry, 04-13, Volume: 60, Issue:7
| Exploration of 2-((Pyridin-4-ylmethyl)amino)nicotinamide Derivatives as Potent Reversal Agents against P-Glycoprotein-Mediated Multidrug Resistance. |
| AID1637320 | Induction of apoptosis in human HeLa cells assessed as necrotic cells at 3 uM after 48 hrs by Annexin V/propidium iodide staining based flow cytometric analysis (Rvb = 21.45 +/- 0.78 %) | 2016 | Bioorganic & medicinal chemistry, 10-01, Volume: 24, Issue:19
| In vitro cytotoxicity of novel 2,5,7-tricarbo-substituted indoles derived from 2-amino-5-bromo-3-iodoacetophenone. |
| AID467996 | Cytotoxic activity against human MCF7 cells after 48 hrs by MTT assay | 2009 | Journal of natural products, Aug, Volume: 72, Issue:8
| Oleanane-type triterpenoids from Aceriphyllum rossii and their cytotoxic activity. |
| AID1461762 | Cytotoxicity against human MCF7/ADR cells assessed as cell growth at 3 mM after 72 hrs relative to control | 2017 | Bioorganic & medicinal chemistry, 09-01, Volume: 25, Issue:17
| Recent synthetic and medicinal perspectives of tryptanthrin. |
| AID1435296 | Dark toxicity in human M14 cells assessed as increase in LDH release at 5 uM measured after 20 mins by spectrophotometric method | 2017 | ACS medicinal chemistry letters, Mar-09, Volume: 8, Issue:3
| Light-Regulated NO Release as a Novel Strategy To Overcome Doxorubicin Multidrug Resistance. |
| AID1625738 | Resistance index, ratio of IC50 for vinblastine resistant/P-gp overexpressing human HCT8 cells to IC50 for human HCT8 cells | 2016 | Journal of medicinal chemistry, 06-23, Volume: 59, Issue:12
| Design, Synthesis, and Evaluation of in Vitro and in Vivo Anticancer Activity of 4-Substituted Coumarins: A Novel Class of Potent Tubulin Polymerization Inhibitors. |
| AID461389 | Antitumor activity against human COLO205 cells | 2010 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 20, Issue:3
| Polar 3-alkylidene-5-pivaloyloxymethyl-5'-hydroxymethyl-gamma-lactones as protein kinase C ligands and antitumor agents. |
| AID1355998 | Cytotoxicity against human HCT116 cells after 72 hrs by MTT assay | 2018 | Journal of natural products, 07-27, Volume: 81, Issue:7
| Aniline-Tetramic Acids from the Deep-Sea-Derived Fungus Cladosporium sphaerospermum L3P3 Cultured with the HDAC Inhibitor SAHA. |
| AID621708 | Binding affinity to human serum transferrin after 12 hrs at pH 7.4 by spectrofluorometer method | 2011 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 21, Issue:19
| Constructing transferrin receptor targeted drug delivery system by using doxorubicin hydrochloride and vanadocene dichloride. |
| AID456253 | Cytotoxicity against human HCT15 cells after 4 days by ELISA reader assay | 2010 | Bioorganic & medicinal chemistry, Jan-01, Volume: 18, Issue:1
| 2-Thienyl-4-furyl-6-aryl pyridine derivatives: synthesis, topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship study. |
| AID1398450 | Cytotoxicity against human PC3 cells after 24 hrs by MTT assay | 2018 | Bioorganic & medicinal chemistry, 08-07, Volume: 26, Issue:14
| Terpenoids with vasorelaxant effects from the Chinese liverwort Scapania carinthiaca. |
| AID1185515 | Cytotoxicity against human DU145 cells after 4 days by CCK-8 assay | 2014 | European journal of medicinal chemistry, Sep-12, Volume: 84 | Synthesis, antitumor activity, and structure-activity relationship study of trihydroxylated 2,4,6-triphenyl pyridines as potent and selective topoisomerase II inhibitors. |
| AID333313 | Cytotoxicity against human HT1080 cells after 72 hrs by MTT assay | 2004 | Journal of natural products, Sep, Volume: 67, Issue:9
| Cytotoxic constituents of roots of Chaerophyllum hirsutum. |
| AID1337471 | Inhibition of human DNA topoisomerase-2alpha at 100 uM using supercoiled pBR322 DNA as substrate after 30 mins by ethidium bromide staining based agarose gel electrophoresis relative to control | 2017 | European journal of medicinal chemistry, Jan-05, Volume: 125 | Novel 2-aryl-4-(4'-hydroxyphenyl)-5H-indeno[1,2-b]pyridines as potent DNA non-intercalative topoisomerase catalytic inhibitors. |
| AID1352064 | Selectivity ratio of IC50 for human K562/A02 cells to IC50 for human K562 cells | 2018 | European journal of medicinal chemistry, Feb-10, Volume: 145 | Synthesis and biological evaluation of bifendate derivatives bearing 6,7-dihydro-dibenzo[c,e]azepine scaffold as potential P-glycoprotein and tumor metastasis inhibitors. |
| AID1318838 | Cytotoxicity against human HeLa cells assessed as decrease in cell viability after 48 hrs by MTT assay | 2016 | European journal of medicinal chemistry, Oct-04, Volume: 121 | Design, structure activity relationship, cytotoxicity and evaluation of antioxidant activity of curcumin derivatives/analogues. |
| AID1441896 | Antiproliferative activity against human HCC1428 cells after 48 hrs by MTT assay | 2017 | European journal of medicinal chemistry, Mar-31, Volume: 129 | Design, synthesis, biological evaluation and molecular modeling study of novel macrocyclic bisbibenzyl analogues as antitubulin agents. |
| AID1776429 | Cytotoxicity against human PC-3 cells assessed as cell viability inhibition for 48 hrs by MTT assay | 2021 | Journal of natural products, 05-28, Volume: 84, Issue:5
| Diverse Prenylated Bibenzyl Enantiomers from the Chinese Liverwort |
| AID484664 | Cytotoxicity against human COLO205 cells after 48 hrs by SRB assay | 2010 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 20, Issue:11
| Synthesis, anticancer activity and apoptosis inducing ability of anthranilamide-PBD conjugates. |
| AID1498577 | Growth inhibition of human MCF7/ADR cells after 48 hrs by MTT assay | 2018 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 28, Issue:14
| The inhibitory effect of kokusaginine on the growth of human breast cancer cells and MDR-resistant cells is mediated by the inhibition of tubulin assembly. |
| AID1168510 | Antitumor activity against mouse S180 cells allografted in mouse assessed as tumor growth inhibition at 1 umol/kg, ip for 7 consecutive days | 2014 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 24, Issue:22
| Synthesis and biological evaluation of a novel class of coumarin derivatives. |
| AID1546808 | Cytotoxicity against human SH-SY5Y cells after 24 hrs by SRB method | 2020 | Journal of natural products, 01-24, Volume: 83, Issue:1
| Prenylated |
| AID478272 | Induction of apoptosis in human HL60 cells assessed as increase of caspase 8 activity at 5 uM after 4 to 24 hrs by luminometric assay | 2010 | European journal of medicinal chemistry, May, Volume: 45, Issue:5
| Modulation of doxorubicin activity in cancer cells by conjugation with fatty acyl and terpenyl hydrazones. |
| AID697853 | Inhibition of horse BChE at 2 mg/ml by Ellman's method | 2012 | Bioorganic & medicinal chemistry, Nov-15, Volume: 20, Issue:22
| Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine. |
| AID1291709 | Antitumor activity against human HepG2 cells xenografted with nude mouse assessed as tumor weight at 5 mg/kg, iv administered every 2 days for 31 days | 2016 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 26, Issue:8
| Synthesis, in vitro and in vivo evaluation of novel substituted N-(4-(2-(4-benzylpiperazin-1-yl)ethoxy)phenyl)-N-methyl-quinazolin-4-amines as potent antitumor agents. |
| AID1227997 | Cytotoxic activity against human HCT116 cells by MTT method | 2015 | Journal of natural products, Apr-24, Volume: 78, Issue:4
| Dimeric Abietane Diterpenoids and Sesquiterpenoid Lactones from Teucrium viscidum. |
| AID1337476 | Antiproliferative activity against human HeLa cells after 72 hrs by CCK8 assay | 2017 | European journal of medicinal chemistry, Jan-05, Volume: 125 | Novel 2-aryl-4-(4'-hydroxyphenyl)-5H-indeno[1,2-b]pyridines as potent DNA non-intercalative topoisomerase catalytic inhibitors. |
| AID1751130 | Cytotoxicity against human MCF7 cells assessed as reduction in cell viability by MTT assay | | | |
| AID1327571 | Cytotoxicity against human A549 cells after 48 hrs by SRB assay | 2016 | Journal of natural products, 08-26, Volume: 79, Issue:8
| Rhizovarins A-F, Indole-Diterpenes from the Mangrove-Derived Endophytic Fungus Mucor irregularis QEN-189. |
| AID1756027 | Cytotoxicity against human MV4-11 cells assessed as inhibition of cell growth measured after 72 hrs by Celltiter-Glo assay | 2021 | Journal of natural products, 01-22, Volume: 84, Issue:1
| Discovery of Venturicidin Congeners and Identification of the Biosynthetic Gene Cluster from |
| AID460539 | Cytotoxicity against human HT-29 cells after 48 hrs by MTT assay | 2010 | Bioorganic & medicinal chemistry, Feb, Volume: 18, Issue:3
| New benzoxanthone derivatives as topoisomerase inhibitors and DNA cross-linkers. |
| AID1166323 | Cytotoxicity against human PC3 cells after 48 hrs by SRB assay | 2014 | European journal of medicinal chemistry, Nov-24, Volume: 87 | β-Ionone derived apoptosis inducing endoperoxides; Discovery of potent leads for anticancer agents. |
| AID1815020 | Cytotoxicity against human PC-3 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay | 2021 | Journal of natural products, 08-27, Volume: 84, Issue:8
| Cryptoyunnanones A-H, Complex Flavanones from |
| AID1577631 | Antiproliferative activity against human MDA-MB-436 cells measured after 72 hrs by Ez-cytox assay | 2019 | Journal of medicinal chemistry, 09-12, Volume: 62, Issue:17
| Discovery and Biological Evaluations of Halogenated 2,4-Diphenyl Indeno[1,2- |
| AID1785517 | Antiproliferative activity against human MCF7 cells incubated for 72 hrs by MTT assay | | | |
| AID376373 | Antitumor activity against mouse P388 cells | 1999 | Journal of natural products, Nov, Volume: 62, Issue:11
| Synthesis of 11,12-epoxydrim-8,12-en-11-ol, 11,12-diacetoxydrimane, and warburganal from (-)-sclareol. |
| AID1168506 | Cytotoxicity against human K562 cells by MTT assay | 2014 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 24, Issue:22
| Synthesis and biological evaluation of a novel class of coumarin derivatives. |
| AID1637341 | Cytotoxicity against human MCF7 cells assessed as cell viability at 20 uM after 2 days by MTT assay relative to control | 2016 | Bioorganic & medicinal chemistry, 10-01, Volume: 24, Issue:19
| In vitro cytotoxicity of novel 2,5,7-tricarbo-substituted indoles derived from 2-amino-5-bromo-3-iodoacetophenone. |
| AID1436224 | Cytotoxicity against human HeLa cells assessed as growth inhibition after 48 hrs by SRB assay | 2017 | European journal of medicinal chemistry, Jan-27, Volume: 126 | Piperlongumine derived cyclic sulfonamides (sultams): Synthesis and in vitro exploration for therapeutic potential against HeLa cancer cell lines. |
| AID1508156 | Cell cycle arrest in human MCF7 cells assessed as accumulation at S phase at 2 uM after 24 hrs by flow cytometric analysis (Rvb = 79.1%) | 2017 | European journal of medicinal chemistry, Oct-20, Volume: 139 | Design, synthesis and biological evaluation of novel pyrazolochalcones as potential modulators of PI3K/Akt/mTOR pathway and inducers of apoptosis in breast cancer cells. |
| AID1500601 | Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay | 2017 | European journal of medicinal chemistry, Sep-29, Volume: 138 | Design, synthesis and biological evaluation of 4-anilinoquinoline derivatives as novel potent tubulin depolymerization agents. |
| AID1402294 | Antiproliferative activity against human SMMC7721 cells after 72 hrs by MTT assay | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | Development of novel bis-pyrazole derivatives as antitumor agents with potent apoptosis induction effects and DNA damage. |
| AID1508159 | Cell cycle arrest in human MCF7 cells assessed as accumulation at G2/M phase at 2 uM after 48 hrs by flow cytometric analysis (Rvb = 8.1%) | 2017 | European journal of medicinal chemistry, Oct-20, Volume: 139 | Design, synthesis and biological evaluation of novel pyrazolochalcones as potential modulators of PI3K/Akt/mTOR pathway and inducers of apoptosis in breast cancer cells. |
| AID459820 | Binding affinity to salmon sperm DNA assessed as melting temperature at 10 uM under low salt concentration by spectrophotometry | 2010 | Bioorganic & medicinal chemistry, Jan-15, Volume: 18, Issue:2
| Triazoloacridin-6-ones as novel inhibitors of the quinone oxidoreductases NQO1 and NQO2. |
| AID735844 | Cytotoxicity against human K562 cells after 72 hrs by MTT assay | 2013 | Journal of natural products, Apr-26, Volume: 76, Issue:4
| Cytotoxic polyketide derivatives from the South China Sea sponge Plakortis simplex. |
| AID490203 | Cytotoxicity against human 786-0 cells by MTT assay | 2010 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 20, Issue:13
| Synthesis of novel beta-carbolines with efficient DNA-binding capacity and potent cytotoxicity. |
| AID1288332 | Antiproliferative activity against human HCT15 cells after 72 hrs by CCK8 assay | 2016 | Bioorganic & medicinal chemistry, Apr-15, Volume: 24, Issue:8
| Design, synthesis, topoisomerase I & II inhibitory activity, antiproliferative activity, and structure-activity relationship study of pyrazoline derivatives: An ATP-competitive human topoisomerase IIα catalytic inhibitor. |
| AID1754632 | Cytotoxicity against human A549 cells assessed as reduction in cell viability after 72 hrs by MTT assay | | | |
| AID1264613 | Cytotoxicity against human K562 cells after 72 hrs by MTT assay | 2015 | Journal of natural products, Nov-25, Volume: 78, Issue:11
| Versixanthones A-F, Cytotoxic Xanthone-Chromanone Dimers from the Marine-Derived Fungus Aspergillus versicolor HDN1009. |
| AID1713810 | Cytotoxicity against human T47D cells assessed as cell growth inhibition measured after 2 days by cell counting kit-8 assay | 2016 | Bioorganic & medicinal chemistry, 11-15, Volume: 24, Issue:22
| Synthesis and topoisomerases inhibitory activity of heteroaromatic chalcones. |
| AID618834 | Cytotoxicity against human K562 cells after 2 days by MTT assay | 2011 | European journal of medicinal chemistry, Sep, Volume: 46, Issue:9
| Synthesis of 4β-triazole-podophyllotoxin derivatives by azide-alkyne cycloaddition and biological evaluation as potential antitumor agents. |
| AID478262 | Cytotoxicity against human vinblastine-resistant KBV1 cells after 72 hrs by MTT assay in presence of 24 mM ABC transporter inhibitor verapamil hydrochloride | 2010 | European journal of medicinal chemistry, May, Volume: 45, Issue:5
| Modulation of doxorubicin activity in cancer cells by conjugation with fatty acyl and terpenyl hydrazones. |
| AID1546812 | Cytotoxicity against human HL60 cells after 72 hrs by MTT assay | 2020 | Journal of natural products, 01-24, Volume: 83, Issue:1
| Prenylated |
| AID1899070 | Resistant index, ratio IC50 for KB/VCR cells over IC50 for KB cells | | | |
| AID1308431 | Cytotoxicity in rat H9c2 cells at 5 uM incubated for 24 hrs in presence of NAC by LDH release-based spectrofluorimetrical analysis relative to control | 2016 | Journal of medicinal chemistry, 05-26, Volume: 59, Issue:10
| H2S-Donating Doxorubicins May Overcome Cardiotoxicity and Multidrug Resistance. |
| AID462329 | Cytotoxicity against human HCT15 cells in presence of 10% fetal bovine serum | 2010 | Bioorganic & medicinal chemistry, Mar-15, Volume: 18, Issue:6
| Synthesis of 2-(thienyl-2-yl or -3-yl)-4-furyl-6-aryl pyridine derivatives and evaluation of their topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship. |
| AID1359650 | Antiproliferative activity against human MCF7 cells after 48 to 72 hrs by MTT assay | 2018 | European journal of medicinal chemistry, May-25, Volume: 152 | Discovery of novel β-carboline/acylhydrazone hybrids as potent antitumor agents and overcome drug resistance. |
| AID1902208 | Cytotoxicity against human Bel-7402 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay | 2022 | European journal of medicinal chemistry, Mar-15, Volume: 232 | Semisynthesis and biological evaluation of (+)-sclerotiorin derivatives as antitumor agents for the treatment of hepatocellular carcinoma. |
| AID478261 | Cytotoxicity against human topotecan-resistant MCF7 cells after 72 hrs by MTT assay | 2010 | European journal of medicinal chemistry, May, Volume: 45, Issue:5
| Modulation of doxorubicin activity in cancer cells by conjugation with fatty acyl and terpenyl hydrazones. |
| AID1404433 | Cytotoxicity against human HeLa cells assessed as decrease in cell viability by MTT assay | 2018 | Journal of natural products, 04-27, Volume: 81, Issue:4
| Penicilindoles A-C, Cytotoxic Indole Diterpenes from the Mangrove-Derived Fungus Eupenicillium sp. HJ002. |
| AID480107 | Cytotoxicity against human MDA-MB-231 cells after 2 days by automatic ELISA reader system | 2010 | Bioorganic & medicinal chemistry, May-01, Volume: 18, Issue:9
| Synthesis, topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship study of hydroxylated 2,4-diphenyl-6-aryl pyridines. |
| AID1637350 | Cytotoxicity against human HeLa cells assessed as cell viability at 2 uM after 2 days by MTT assay relative to control | 2016 | Bioorganic & medicinal chemistry, 10-01, Volume: 24, Issue:19
| In vitro cytotoxicity of novel 2,5,7-tricarbo-substituted indoles derived from 2-amino-5-bromo-3-iodoacetophenone. |
| AID621711 | Binding affinity to human apo transferrin after 12 hrs at pH 4.8 by spectrofluorometer method | 2011 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 21, Issue:19
| Constructing transferrin receptor targeted drug delivery system by using doxorubicin hydrochloride and vanadocene dichloride. |
| AID122106 | Antitumor activity against mice baering P388 leukemia (10e6 cells) implanted ip on day 0, after treatment with single ip dose 7.5 mg/kg on day 1. | 1984 | Journal of medicinal chemistry, May, Volume: 27, Issue:5
| Intensely potent morpholinyl anthracyclines. |
| AID490206 | Cytotoxicity against human HT-29 cells by MTT assay | 2010 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 20, Issue:13
| Synthesis of novel beta-carbolines with efficient DNA-binding capacity and potent cytotoxicity. |
| AID1202747 | Growth inhibition of human Saos2 cells by MTT method | 2015 | Journal of natural products, Feb-27, Volume: 78, Issue:2
| 1,19-seco-Avermectin analogues from a ΔaveCDE mutant Streptomyces avermectinius strain. |
| AID1907346 | Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay | 2022 | European journal of medicinal chemistry, Jun-05, Volume: 236 | Synthesis and structure-activity relationship study of a potent MHO7 analogue as potential anti-triple negative breast cancer agent. |
| AID549506 | Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay | 2011 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 21, Issue:1
| Efficient synthesis and biological evaluation of epiceanothic acid and related compounds. |
| AID1405494 | Cytotoxicity against human HPDE6c7 cells | 2018 | European journal of medicinal chemistry, Aug-05, Volume: 156 | Copper(I) oxide nanoparticles catalyzed click chemistry based synthesis of melampomagnolide B-triazole conjugates and their anti-cancer activities. |
| AID1867130 | Cytotoxicity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 72 hrs by SRB assay | 2022 | Journal of natural products, 04-22, Volume: 85, Issue:4
| Cytotoxic Nitrobenzoyl Sesquiterpenoids from an Antarctica Sponge-Derived |
| AID1851419 | Antiproliferative activity against human K562 cells assessed as inhibition of cell growth | 2022 | Bioorganic & medicinal chemistry letters, 10-01, Volume: 73 | Synthesis and antitumor activity of a series of novel N-aryl-5-(2,2,2-trifluoroethoxy)-1,5-dihydro-2H-pyrrol-2-ones derivatives. |
| AID467760 | Cytotoxicity against human DU145 cells by MTT assay | 2009 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 19, Issue:23
| Oxiranylmethyloxy or thiiranylmethyloxy-azaxanthones and -acridone analogues as potential topoisomerase I inhibitors. |
| AID1401029 | Antiproliferative activity against human MCF7 cells after 96 hrs by MTT assay | 2017 | European journal of medicinal chemistry, Dec-01, Volume: 141 | Synthesis, anticancer evaluation and pharmacokinetic study of novel 10-O-phenyl ethers of dihydroartemisinin. |
| AID1435299 | Cytotoxicity against 7 mW/cm'2 irradiated rat H9c2 cells at 5 uM measured after 20 mins by spectrophotometric method | 2017 | ACS medicinal chemistry letters, Mar-09, Volume: 8, Issue:3
| Light-Regulated NO Release as a Novel Strategy To Overcome Doxorubicin Multidrug Resistance. |
| AID1358353 | Selectivity index, ratio of IC50 against human Aspc-1 cells under normoxic condition to IC50 for human Aspc-1 cells under hypoxic condition | 2018 | European journal of medicinal chemistry, May-10, Volume: 151 | Syntheses and anti-pancreatic cancer activities of rakicidin A analogues. |
| AID1895015 | Anticancer activity against human MCF7 cells assessed as inhibition of cell growth | 2021 | European journal of medicinal chemistry, Aug-05, Volume: 220 | Discovery of cytotoxic natural products from Red Sea sponges: Structure and synthesis. |
| AID1757275 | Antiproliferative activity against human HCT-8 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay | 2021 | European journal of medicinal chemistry, Apr-15, Volume: 216 | Discovery of novel N-benzylbenzamide derivatives as tubulin polymerization inhibitors with potent antitumor activities. |
| AID1696721 | Cytotoxicity against human K562 cells assessed as reduction in cell viability after 48 hrs by MTT assay | 2020 | Journal of natural products, 09-25, Volume: 83, Issue:9
| Dimeric Tetrahydroanthracene Regioisomers and Their Monomeric Precursor Produced by |
| AID1308433 | Induction of intracellular ROS accumulation in human U2OS cells at 5 uM incubated for 24 hrs by DCFDA-AM probe-based fluorimetrical analysis relative to control | 2016 | Journal of medicinal chemistry, 05-26, Volume: 59, Issue:10
| H2S-Donating Doxorubicins May Overcome Cardiotoxicity and Multidrug Resistance. |
| AID1675631 | Cytotoxicity against human SH-SY5Y cells assessed as reduction in cell viability by SRB assay | 2020 | Journal of natural products, 09-25, Volume: 83, Issue:9
| Monacycliones G-K and |
| AID1387376 | Cytotoxicity against human A549 cells after 72 hrs by MTT assay | 2018 | Journal of natural products, 09-28, Volume: 81, Issue:9
| Dinghupeptins A-D, Chymotrypsin Inhibitory Cyclodepsipeptides Produced by a Soil-Derived Streptomyces. |
| AID1817885 | Antiproliferative activity against human HeLa cells assessed as reduction in cell viability after 48 hrs by Ez-cytoX based microplate reader method | 2021 | European journal of medicinal chemistry, Dec-15, Volume: 226 | Discovery of a 2,4-diphenyl-5,6-dihydrobenzo(h)quinolin-8-amine derivative as a novel DNA intercalating topoisomerase IIα poison. |
| AID1625737 | Cytotoxicity against vinblastine resistant/P-gp overexpressing human HCT8 cells assessed as reduction in cell growth after 24 hrs by MTT assay | 2016 | Journal of medicinal chemistry, 06-23, Volume: 59, Issue:12
| Design, Synthesis, and Evaluation of in Vitro and in Vivo Anticancer Activity of 4-Substituted Coumarins: A Novel Class of Potent Tubulin Polymerization Inhibitors. |
| AID1435968 | Cytotoxicity against human A549 cells assessed as growth inhibition at 10 uM measured after 72 hrs by CCK-8 assay relative to control | | | |
| AID1330743 | Cytotoxicity against human HeLa cells assessed as reduction in cell growth after 72 hrs by CCK8 assay | 2016 | European journal of medicinal chemistry, Nov-10, Volume: 123 | Synthesis and biological evaluation of C1-O-substituted-3-(3-butylamino-2-hydroxy-propoxy)-xanthen-9-one as topoisomerase IIα catalytic inhibitors. |
| AID1441122 | Disruption of cancer stem cells spheroids derived from human BT474 cells at 20 uM after 3 days by microscopic analysis | 2017 | Journal of medicinal chemistry, 03-09, Volume: 60, Issue:5
| Replacing d-Glucosamine with Its l-Enantiomer in Glycosylated Antitumor Ether Lipids (GAELs) Retains Cytotoxic Effects against Epithelial Cancer Cells and Cancer Stem Cells. |
| AID1583363 | Cytotoxicity against mouse 3T3 cells assessed as reduction in cell viability after 72 hrs by MTT assay | 2020 | Journal of medicinal chemistry, 02-27, Volume: 63, Issue:4
| Identification of Parthenolide Dimers as Activators of Pyruvate Kinase M2 in Xenografts of Glioblastoma Multiforme in Vivo. |
| AID1308403 | Cytotoxicity in human U2OS/DX100 cells at 5 uM incubated for 24 hrs by LDH release-based spectrofluorimetrical analysis | 2016 | Journal of medicinal chemistry, 05-26, Volume: 59, Issue:10
| H2S-Donating Doxorubicins May Overcome Cardiotoxicity and Multidrug Resistance. |
| AID1308424 | Cytotoxicity in rat H9c2 cells assessed as intracellular ROS accumulation at 5 uM incubated for 24 hrs by DCFDA-AM probe-based fluorimetrical analysis relative to control | 2016 | Journal of medicinal chemistry, 05-26, Volume: 59, Issue:10
| H2S-Donating Doxorubicins May Overcome Cardiotoxicity and Multidrug Resistance. |
| AID478104 | Cytotoxicity against human KB cells after 45 hrs by resazurin microplate assay | 2010 | Journal of natural products, Apr-23, Volume: 73, Issue:4
| Hopane-type triterpenes and binaphthopyrones from the scale insect pathogenic fungus Aschersonia paraphysata BCC 11964. |
| AID673202 | Antiproliferative activity against mouse BALB/3T3 cells after 72 hrs by SRB assay | 2012 | Bioorganic & medicinal chemistry, Aug-01, Volume: 20, Issue:15
| Synthesis and in vitro antiproliferative activity of new 11-aminoalkylamino-substituted 5H- and 6H-indolo[2,3-b]quinolines; structure-activity relationships of neocryptolepines and 6-methyl congeners. |
| AID494521 | Inhibition of tubulin polymerization in human K562 cells | 2010 | European journal of medicinal chemistry, Aug, Volume: 45, Issue:8
| Synthesis, antiproliferative activity and inhibition of tubulin polymerization by anthracenone-based oxime derivatives. |
| AID1508150 | Cytotoxicity against human MDA-MB-231 cells assessed as growth inhibition after 48 hrs by MTT assay | 2017 | European journal of medicinal chemistry, Oct-20, Volume: 139 | Design, synthesis and biological evaluation of novel pyrazolochalcones as potential modulators of PI3K/Akt/mTOR pathway and inducers of apoptosis in breast cancer cells. |
| AID1543250 | Cytotoxicity in human KB cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay | 2019 | Journal of natural products, 07-26, Volume: 82, Issue:7
| Prenylated Bibenzyls from the Chinese Liverwort |
| AID1185752 | Cytotoxicity against human CCRF-CEM cells after 48 hrs by Alamar blue assay | 2014 | European journal of medicinal chemistry, 09-12, Volume: 84 | Synthesis and evaluation of the cytotoxic activity of 1,2-furanonaphthoquinones tethered to 1,2,3-1H-triazoles in myeloid and lymphoid leukemia cell lines. |
| AID478259 | Cytotoxicity against human topotecan-resistant MCF7 cells after 24 hrs by MTT assay | 2010 | European journal of medicinal chemistry, May, Volume: 45, Issue:5
| Modulation of doxorubicin activity in cancer cells by conjugation with fatty acyl and terpenyl hydrazones. |
| AID1308416 | Drug uptake in human U2OS/DX100 cells at 5 uM incubated for 24 hrs by fluorimetrical analysis | 2016 | Journal of medicinal chemistry, 05-26, Volume: 59, Issue:10
| H2S-Donating Doxorubicins May Overcome Cardiotoxicity and Multidrug Resistance. |
| AID1498374 | Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay | 2018 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 28, Issue:14
| 2-Substituted-1-(2-morpholinoethyl)-1H-naphtho[2,3-d]imidazole-4,9-diones: Design, synthesis and antiproliferative activity. |
| AID1637407 | Resistance factor, ratio of IC50 for human K562/ADR cells to IC50 for human K562 cells | 2016 | Bioorganic & medicinal chemistry letters, 09-15, Volume: 26, Issue:18
| Design, synthesis and evaluation of the multidrug resistance-reversing activity of pyridine acid esters of podophyllotoxin in human leukemia cells. |
| AID1671750 | Inhibition of TGF-beta1-induced cell migration in human SMMC-7721 cells at 0.5 uM incubated for 24 hrs by wound healing assay relative to control | 2019 | European journal of medicinal chemistry, Mar-15, Volume: 166 | Excellent antitumor and antimetastatic activities based on novel coumarin/pyrazole oxime hybrids. |
| AID1355997 | Cytotoxicity against human HL60 cells after 72 hrs by MTT assay | 2018 | Journal of natural products, 07-27, Volume: 81, Issue:7
| Aniline-Tetramic Acids from the Deep-Sea-Derived Fungus Cladosporium sphaerospermum L3P3 Cultured with the HDAC Inhibitor SAHA. |
| AID1543246 | Cytotoxicity in human MCF7 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay | 2019 | Journal of natural products, 07-26, Volume: 82, Issue:7
| Prenylated Bibenzyls from the Chinese Liverwort |
| AID478252 | Cytotoxicity against human 518A2 cells after 72 hrs by MTT assay | 2010 | European journal of medicinal chemistry, May, Volume: 45, Issue:5
| Modulation of doxorubicin activity in cancer cells by conjugation with fatty acyl and terpenyl hydrazones. |
| AID1436223 | Cytotoxicity against human HeLa cells assessed as cell growth at 10'-4 M after 48 hrs by SRB assay relative to control | 2017 | European journal of medicinal chemistry, Jan-27, Volume: 126 | Piperlongumine derived cyclic sulfonamides (sultams): Synthesis and in vitro exploration for therapeutic potential against HeLa cancer cell lines. |
| AID494520 | Cell growth inhibition of human K562 cells after 48 hrs | 2010 | European journal of medicinal chemistry, Aug, Volume: 45, Issue:8
| Synthesis, antiproliferative activity and inhibition of tubulin polymerization by anthracenone-based oxime derivatives. |
| AID1663789 | Anticancer activity against human Caco2 cells assessed as inhibition of cell proliferation | 2020 | Bioorganic & medicinal chemistry letters, 07-15, Volume: 30, Issue:14
| Synthesis and evaluation of novel sulfonamide analogues of 6/7-aminoflavones as anticancer agents via topoisomerase II inhibition. |
| AID8824 | Cytotoxicity against A-498 cell line in the purdue cell culture screen was determined | 1999 | Bioorganic & medicinal chemistry letters, Feb-08, Volume: 9, Issue:3
| On the relationship of OSW-1 to the cephalostatins. |
| AID1504775 | Cytotoxicity against human A549 cells by SRB assay | 2017 | Journal of natural products, 12-22, Volume: 80, Issue:12
| Cephanolides A-J, Cephalotane-Type Diterpenoids from Cephalotaxus sinensis. |
| AID512239 | Anticancer activity against human A2780 cells after 48 hrs by SRB assay | 2010 | European journal of medicinal chemistry, Sep, Volume: 45, Issue:9
| Design, synthesis and biological evaluation of 3,5-diaryl-isoxazoline/isoxazole-pyrrolobenzodiazepine conjugates as potential anticancer agents. |
| AID1890787 | Cytotoxicity against human ACHN cells assessed as cell growth inhibition incubated for 48 hrs by SRB method | 2022 | Journal of natural products, 04-22, Volume: 85, Issue:4
| Isolation, Structure Determination, and Semisynthesis of Diphenazine Compounds from a Deep-Sea-Derived Strain of the Fungus |
| AID1428410 | Cytotoxicity against multidrug resistant human MCF7 cells cultured in vinblastine free medium assessed as growth inhibition after 72 hrs by SRB assay | | | |
| AID1402311 | Induction of DNA double stranded breaks in human SMMC7721 cells assessed as increase in H2AX phosphorylation at S139 at 0.8 uM after 72 hrs by Western blot analysis | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | Development of novel bis-pyrazole derivatives as antitumor agents with potent apoptosis induction effects and DNA damage. |
| AID490201 | Cytotoxicity against human KB cells by MTT assay | 2010 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 20, Issue:13
| Synthesis of novel beta-carbolines with efficient DNA-binding capacity and potent cytotoxicity. |
| AID490200 | Cytotoxicity against human 769-P cells by MTT assay | 2010 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 20, Issue:13
| Synthesis of novel beta-carbolines with efficient DNA-binding capacity and potent cytotoxicity. |
| AID718786 | Cytotoxicity against human BGC823 cells after 48 hrs by MTT assay | 2012 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 22, Issue:24
| Angucyclines from an insect-derived actinobacterium Amycolatopsis sp. HCa1 and their cytotoxic activity. |
| AID1762047 | Cytotoxicity against human MCF7 cells assessed as inhibition of cell proliferation after 72 hrs by MTT assay | 2021 | Bioorganic & medicinal chemistry letters, 05-15, Volume: 40 | One pot synthesis, in silico study and evaluation of some novel flavonoids as potent topoisomerase II inhibitors. |
| AID1428692 | Antiproliferative activity against human HCT15 cells after 72 hrs by CCK8 assay | 2017 | European journal of medicinal chemistry, Feb-15, Volume: 127 | Rational design, synthesis, and evaluation of novel 2,4-Chloro- and Hydroxy-Substituted diphenyl Benzofuro[3,2-b]Pyridines: Non-intercalative catalytic topoisomerase I and II dual inhibitor. |
| AID1180307 | Cytotoxicity against human HeLa cells by SRB method | 2014 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 24, Issue:15
| One pot three components microwave assisted and conventional synthesis of new 3-(4-chloro-2-hydroxyphenyl)-2-(substituted) thiazolidin-4-one as antimicrobial agents. |
| AID599176 | Cytotoxicity against human HL60 cells after 2 days | 2011 | European journal of medicinal chemistry, Jun, Volume: 46, Issue:6
| Synthesis, biological evaluation, and molecular docking study of 3-(3'-heteroatom substituted-2'-hydroxy-1'-propyloxy) xanthone analogues as novel topoisomerase IIα catalytic inhibitor. |
| AID1757274 | Antiproliferative activity against human K562 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay | 2021 | European journal of medicinal chemistry, Apr-15, Volume: 216 | Discovery of novel N-benzylbenzamide derivatives as tubulin polymerization inhibitors with potent antitumor activities. |
| AID689425 | Cytotoxicity against human KB cells after 72 hrs by SRB assay | 2012 | Journal of medicinal chemistry, Jun-14, Volume: 55, Issue:11
| Synthesis and biological evaluation of new amino acid and dipeptide derivatives of neocryptolepine as anticancer agents. |
| AID1869702 | Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 72 hrs by SRB assay | 2022 | Journal of natural products, 07-22, Volume: 85, Issue:7
| Suncheonosides E-M and Benzothioate Derivatives from the Marine-Derived |
| AID509770 | Reversal of P-gp-mediated multidrug-resistance in human KB/VCR cells assessed as increase in intracellular adriamycin accumulation at 4 uM after 1 hr by flow cytometry relative to control | 2010 | Bioorganic & medicinal chemistry, Sep-15, Volume: 18, Issue:18
| Bisbibenzyl derivatives sensitize vincristine-resistant KB/VCR cells to chemotherapeutic agents by retarding P-gp activity. |
| AID1785519 | Resistance ratio of IC50 for human MCF-7 cells to IC50 for human MCF-7/ADR cells | | | |
| AID1172773 | Anti-proliferative activity against human NCI-H23 cells by XTT assay | 2014 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 24, Issue:22
| Synthesis and SAR studies of bis-chromenone derivatives for anti-proliferative activity against human cancer cells. |
| AID1783256 | Cytotoxicity against human HCT116 cells assessed as inhibition of proliferation incubated for 72 hrs by MTT assay | | | |
| AID636833 | Cytotoxicity against human MCF7 cells by resazurin microplate assay | 2011 | Journal of natural products, Oct-28, Volume: 74, Issue:10
| Lanostane and hopane triterpenes from the entomopathogenic fungus Hypocrella sp. BCC 14524. |
| AID509774 | Induction of adriamycin accumulation in human KB cells at 4 to 6 uM after 1 hr by flow cytometry | 2010 | Bioorganic & medicinal chemistry, Sep-15, Volume: 18, Issue:18
| Bisbibenzyl derivatives sensitize vincristine-resistant KB/VCR cells to chemotherapeutic agents by retarding P-gp activity. |
| AID452684 | Cytotoxicity against human HeLa cells after 3 days | 2010 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 20, Issue:1
| 2,6-Dithienyl-4-furyl pyridines: Synthesis, topoisomerase I and II inhibition, cytotoxicity, structure-activity relationship, and docking study. |
| AID588210 | Human drug-induced liver injury (DILI) modelling dataset from Ekins et al | 2010 | Drug metabolism and disposition: the biological fate of chemicals, Dec, Volume: 38, Issue:12
| A predictive ligand-based Bayesian model for human drug-induced liver injury. |
| AID569515 | Cytotoxicity against human A2780 cells after 48 hrs by sulforhodamine B assay | 2011 | European journal of medicinal chemistry, Feb, Volume: 46, Issue:2
| Synthesis and biological evaluation of 3,5-diaryl isoxazoline/isoxazole linked 2,3-dihydroquinazolinone hybrids as anticancer agents. |
| AID459819 | Binding affinity to salmon sperm DNA assessed as change in melting temperature at 10 uM under low salt concentration by spectrophotometry | 2010 | Bioorganic & medicinal chemistry, Jan-15, Volume: 18, Issue:2
| Triazoloacridin-6-ones as novel inhibitors of the quinone oxidoreductases NQO1 and NQO2. |
| AID1126866 | Cytotoxicity against mouse BALB/3T3 cells assessed as growth inhibition after 72 hrs by SRB assay | 2014 | European journal of medicinal chemistry, May-06, Volume: 78 | Searching for new derivatives of neocryptolepine: synthesis, antiproliferative, antimicrobial and antifungal activities. |
| AID1320983 | Cytotoxicity against human HeLa cells assessed as decrease in cell viability after 48 hrs by MTT assay | 2016 | European journal of medicinal chemistry, Oct-04, Volume: 121 | Design, synthesis and biological evaluation of novel macrocyclic bisbibenzyl analogues as tubulin polymerization inhibitors. |
| AID1428415 | Cytotoxicity against human HCT116 cells assessed as growth inhibition after 72 hrs by SRB assay | | | |
| AID1890791 | Cytotoxicity against human MDA-MB-231 cells assessed as cell growth inhibition incubated for 48 hrs by SRB method | 2022 | Journal of natural products, 04-22, Volume: 85, Issue:4
| Isolation, Structure Determination, and Semisynthesis of Diphenazine Compounds from a Deep-Sea-Derived Strain of the Fungus |
| AID633823 | Cytotoxicity against human HepG2 cells after 24 hrs by MTT assay | 2012 | Bioorganic & medicinal chemistry, Jan-01, Volume: 20, Issue:1
| Synthesis, antiproliferative activity and genotoxicity of novel anthracene-containing aminophosphonates and a new anthracene-derived Schiff base. |
| AID1330744 | Cytotoxicity against human NCI-N87 cells assessed as reduction in cell growth after 72 hrs by CCK8 assay | 2016 | European journal of medicinal chemistry, Nov-10, Volume: 123 | Synthesis and biological evaluation of C1-O-substituted-3-(3-butylamino-2-hydroxy-propoxy)-xanthen-9-one as topoisomerase IIα catalytic inhibitors. |
| AID1675630 | Cytotoxicity against human Bel-7402 cells assessed as reduction in cell viability by SRB assay | 2020 | Journal of natural products, 09-25, Volume: 83, Issue:9
| Monacycliones G-K and |
| AID1401808 | Cytotoxicity against human MCF10A cells after 72 hrs by cell counting kit-8 analysis | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | Design, synthesis, and biological evaluation of 1,3-diarylisoquinolines as novel topoisomerase I catalytic inhibitors. |
| AID1421548 | Antiproliferative activity against human HeLa cells assessed as inhibition of cell growth at 1 uM after 72 hrs by sulforhodamine B assay relative to control | 2018 | European journal of medicinal chemistry, Oct-05, Volume: 158 | Four new antitumor metabolites isolated from a mutant 3-f-31 strain derived from Penicillium purpurogenum G59. |
| AID1421556 | Antiproliferative activity against human SW480 cells assessed as inhibition of cell growth at 1 uM after 72 hrs by sulforhodamine B assay relative to control | 2018 | European journal of medicinal chemistry, Oct-05, Volume: 158 | Four new antitumor metabolites isolated from a mutant 3-f-31 strain derived from Penicillium purpurogenum G59. |
| AID1577580 | Antiproliferative activity against human DU145 cells measured after 72 hrs by EZ-Cytox assay | 2019 | Journal of medicinal chemistry, 09-12, Volume: 62, Issue:17
| Discovery and Biological Evaluations of Halogenated 2,4-Diphenyl Indeno[1,2- |
| AID357613 | Antiproliferative activity against mouse B16-BL6 cells assessed as cell viability after 72 hrs by MTT assay | 2001 | Journal of natural products, Sep, Volume: 64, Issue:9
| New spirostanol steroids and steroidal saponins from roots and rhizomes of Dracaena angustifolia and their antiproliferative activity. |
| AID1320984 | Cytotoxicity against human K562 cells assessed as decrease in cell viability after 48 hrs by MTT assay | 2016 | European journal of medicinal chemistry, Oct-04, Volume: 121 | Design, synthesis and biological evaluation of novel macrocyclic bisbibenzyl analogues as tubulin polymerization inhibitors. |
| AID512162 | Cytotoxicity against human SiHa cells after 48 hrs by SRB assay | 2010 | European journal of medicinal chemistry, Sep, Volume: 45, Issue:9
| Synthesis and biological evaluation of cinnamido linked pyrrolo[2,1-c][1,4]benzodiazepines as antimitotic agents. |
| AID1638222 | Cytotoxicity against human Bel7042 cells after 72 hrs by MTT assay | 2019 | European journal of medicinal chemistry, Mar-01, Volume: 165 | Discovery and synthesis of sulfur-containing 6-substituted 5,8-dimethoxy-1,4-naphthoquinone oxime derivatives as new and potential anti-MDR cancer agents. |
| AID1421559 | Antiproliferative activity against human BxPC3 cells assessed as inhibition of cell growth at 1 uM after 72 hrs by sulforhodamine B assay relative to control | 2018 | European journal of medicinal chemistry, Oct-05, Volume: 158 | Four new antitumor metabolites isolated from a mutant 3-f-31 strain derived from Penicillium purpurogenum G59. |
| AID1408890 | Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability after 48 hrs by MTT assay | 2018 | European journal of medicinal chemistry, Oct-05, Volume: 158 | Discovery of novel human inosine 5'-monophosphate dehydrogenase 2 (hIMPDH2) inhibitors as potential anticancer agents. |
| AID1126870 | Cytotoxicity against human KB cells assessed as growth inhibition after 72 hrs by SRB assay | 2014 | European journal of medicinal chemistry, May-06, Volume: 78 | Searching for new derivatives of neocryptolepine: synthesis, antiproliferative, antimicrobial and antifungal activities. |
| AID599173 | Cytotoxicity against human HCT116 cells after 2 days | 2011 | European journal of medicinal chemistry, Jun, Volume: 46, Issue:6
| Synthesis, biological evaluation, and molecular docking study of 3-(3'-heteroatom substituted-2'-hydroxy-1'-propyloxy) xanthone analogues as novel topoisomerase IIα catalytic inhibitor. |
| AID1617192 | Cytotoxicity against human NUGC3 cells assessed as cell growth inhibition measured after 48 hrs by SRB assay | 2019 | Journal of natural products, 11-22, Volume: 82, Issue:11
| Resorcinosides A and B, Glycosylated Alkylresorcinols from a Marine-Derived Strain of the Fungus |
| AID736708 | Cytotoxicity against human A549 cells by MTT assay | 2013 | Journal of natural products, Apr-26, Volume: 76, Issue:4
| Steroids glycosylated with both D- and L-arabinoses from the South China Sea gorgonian Dichotella gemmacea. |
| AID1398448 | Cytotoxicity against human MCF7 cells after 24 hrs by MTT assay | 2018 | Bioorganic & medicinal chemistry, 08-07, Volume: 26, Issue:14
| Terpenoids with vasorelaxant effects from the Chinese liverwort Scapania carinthiaca. |
| AID551372 | Cytotoxicity against human MGC803 cells after 48 hrs by MTT assay | 2011 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 21, Issue:1
| Synthesis and biological evaluation of novel exo-methylene cyclopentanone tetracyclic diterpenoids as antitumor agents. |
| AID1430413 | Cytotoxicity against human HeLa cells assessed as cell growth at 10'-5 M after 48 hrs by SRB assay relative to control | 2017 | Bioorganic & medicinal chemistry letters, 03-01, Volume: 27, Issue:5
| Methylsulfonyl benzothiazoles (MSBT) derivatives: Search for new potential antimicrobial and anticancer agents. |
| AID636832 | Cytotoxicity against human NCI-H187 cells by resazurin microplate assay | 2011 | Journal of natural products, Oct-28, Volume: 74, Issue:10
| Lanostane and hopane triterpenes from the entomopathogenic fungus Hypocrella sp. BCC 14524. |
| AID460542 | Cytotoxicity against human HL60 cells after 48 hrs by MTT assay | 2010 | Bioorganic & medicinal chemistry, Feb, Volume: 18, Issue:3
| New benzoxanthone derivatives as topoisomerase inhibitors and DNA cross-linkers. |
| AID1625415 | Cytotoxicity against human Caco2 cells assessed as reduction in cell viability by MTT assay | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4
| Bafilomycins and Odoriferous Sesquiterpenoids from Streptomyces albolongus Isolated from Elephas maximus Feces. |
| AID1132906 | Binding affinity to calf thymus DNA assessed as change in melting temperature at 5 uM by spectrophotometer analysis | 1978 | Journal of medicinal chemistry, Aug, Volume: 21, Issue:8
| Antitumor anthracycline antibiotics. Structure-activity and structure-cardiotoxicity relationships of rubidazone analogues. |
| AID566854 | Cytotoxicity against human HL60 cells at 1 uM after 48 hrs by MTT assay | 2010 | Journal of natural products, Dec-27, Volume: 73, Issue:12
| Cytotoxic triterpenoids from Maytenus retusa. |
| AID1318839 | Cytotoxicity against human HCT116 cells assessed as decrease in cell viability after 48 hrs by MTT assay | 2016 | European journal of medicinal chemistry, Oct-04, Volume: 121 | Design, structure activity relationship, cytotoxicity and evaluation of antioxidant activity of curcumin derivatives/analogues. |
| AID1363195 | Antiproliferative activity against human HeLa cells after 72 hrs by EZ-CYTOX reagent based assay | 2018 | Bioorganic & medicinal chemistry, 10-01, Volume: 26, Issue:18
| A new phenolic series of indenopyridinone as topoisomerase inhibitors: Design, synthesis, and structure-activity relationships. |
| AID619816 | Cytotoxicity against human 769-P cells by MTT assay | 2011 | European journal of medicinal chemistry, Oct, Volume: 46, Issue:10
| Synthesis and biological evaluation of 1,9-disubstituted β-carbolines as potent DNA intercalating and cytotoxic agents. |
| AID460538 | Cytotoxicity against human HeLa cells after 48 hrs by MTT assay | 2010 | Bioorganic & medicinal chemistry, Feb, Volume: 18, Issue:3
| New benzoxanthone derivatives as topoisomerase inhibitors and DNA cross-linkers. |
| AID1401809 | Cytotoxicity against human T47D cells after 72 hrs by cell counting kit-8 analysis | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | Design, synthesis, and biological evaluation of 1,3-diarylisoquinolines as novel topoisomerase I catalytic inhibitors. |
| AID303685 | Inhibition of porcine brain tubulin polymerization | 2007 | Journal of medicinal chemistry, Nov-29, Volume: 50, Issue:24
| Sulfonate derivatives of naphtho[2,3-b]thiophen-4(9H)-one and 9(10H)-anthracenone as highly active antimicrotubule agents. Synthesis, antiproliferative activity, and inhibition of tubulin polymerization. |
| AID1706708 | Antiproliferative activity against human A549 cells assessed as reduction in cell viability by MTT assay | 2021 | European journal of medicinal chemistry, Jan-01, Volume: 209 | Discovery of lysosome-targeted covalent anticancer agents based on isosteviol skeleton. |
| AID1523994 | Antiproliferative activity against human MDA-MB-231 cells measured after 72 hrs by MTT assay | 2019 | European journal of medicinal chemistry, Mar-15, Volume: 166 | Synthesis and structure-activity relationship studies of parthenolide derivatives as potential anti-triple negative breast cancer agents. |
| AID478276 | Induction of apoptosis in human 518A2 cells assessed as increase of caspase 3 activity at 5 uM measured up to 12 hrs by luminometric assay | 2010 | European journal of medicinal chemistry, May, Volume: 45, Issue:5
| Modulation of doxorubicin activity in cancer cells by conjugation with fatty acyl and terpenyl hydrazones. |
| AID1543244 | Cytotoxicity in human NCI-H1299 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay | 2019 | Journal of natural products, 07-26, Volume: 82, Issue:7
| Prenylated Bibenzyls from the Chinese Liverwort |
| AID1625850 | Toxicity in mouse xenografted with P-gp overexpressing human MCF7/ADR cells assessed as body weight loss at 4 mg/kg, iv qd administered every 2 days measured during compound dosing | 2016 | Journal of medicinal chemistry, 06-23, Volume: 59, Issue:12
| Design, Synthesis, and Evaluation of in Vitro and in Vivo Anticancer Activity of 4-Substituted Coumarins: A Novel Class of Potent Tubulin Polymerization Inhibitors. |
| AID1168527 | Toxicity in mouse S180 cells allografted mouse assessed as spleen index at 1 umol/kg, ip for 7 consecutive days measured 24 hrs after last dose (Rvb = 7.25 +/- 1.60 No_unit) | 2014 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 24, Issue:22
| Synthesis and biological evaluation of a novel class of coumarin derivatives. |
| AID484657 | Cytotoxicity against human ZR-75-1 cells after 48 hrs by SRB assay | 2010 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 20, Issue:11
| Synthesis, anticancer activity and apoptosis inducing ability of anthranilamide-PBD conjugates. |
| AID1391798 | Cytotoxicity against human K562 cells assessed as reduction in cell viability after 48 hrs by MTT assay | 2018 | Bioorganic & medicinal chemistry, 05-15, Volume: 26, Issue:9
| Design, synthesis and biological evaluation of novel tetrahydroisoquinoline derivatives as P-glycoprotein-mediated multidrug resistance inhibitors. |
| AID1657550 | Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay | | | |
| AID1637352 | Cytotoxicity against human HeLa cells assessed as cell viability at 0.5 uM after 2 days by MTT assay relative to control | 2016 | Bioorganic & medicinal chemistry, 10-01, Volume: 24, Issue:19
| In vitro cytotoxicity of novel 2,5,7-tricarbo-substituted indoles derived from 2-amino-5-bromo-3-iodoacetophenone. |
| AID1264612 | Cytotoxicity against human HL60 cells after 72 hrs by MTT assay | 2015 | Journal of natural products, Nov-25, Volume: 78, Issue:11
| Versixanthones A-F, Cytotoxic Xanthone-Chromanone Dimers from the Marine-Derived Fungus Aspergillus versicolor HDN1009. |
| AID1423927 | Cytotoxicity against human HCT116 cells assessed as inhibition of growth incubated for 72 hrs by MTT assay | 2017 | Journal of natural products, 04-28, Volume: 80, Issue:4
| Cytotoxic Fusicoccane-Type Diterpenoids from Streptomyces violascens Isolated from Ailuropoda melanoleuca Feces. |
| AID1675628 | Cytotoxicity against human ASPC1 cells assessed as reduction in cell viability by SRB assay | 2020 | Journal of natural products, 09-25, Volume: 83, Issue:9
| Monacycliones G-K and |
| AID1355291 | Cytotoxicity against human PC3 cells assessed as inhibition of cell proliferation measured after 72 hrs by sulforhodamine B assay | 2018 | Journal of natural products, 06-22, Volume: 81, Issue:6
| Cytotoxic Drimane Sesquiterpenoids Isolated from Perenniporia maackiae. |
| AID1236895 | Cytotoxicity against human T47D cells incubated from day 2 to day 4 by CCK8 assay | 2015 | Bioorganic & medicinal chemistry, Jul-01, Volume: 23, Issue:13
| Synthesis, topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship study of 2-phenyl- or hydroxylated 2-phenyl-4-aryl-5H-indeno[1,2-b]pyridines. |
| AID1833615 | Cytotoxicity against human A549 cells assessed as cell growth inhibition by SRB assay | 2021 | Journal of natural products, 11-26, Volume: 84, Issue:11
| Sublyratins A-O, Labdane-Type Diterpenoids from |
| AID249855 | Percent control of human mammary adenocarcinoma MCF-7 cell line proliferation at 3 ng/mL | 2004 | Bioorganic & medicinal chemistry letters, Sep-20, Volume: 14, Issue:18
| Formation of squaric acid amides of anthracycline antibiotics. Synthesis and cytotoxic properties. |
| AID718784 | Cytotoxicity against human KB cells after 48 hrs by MTT assay | 2012 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 22, Issue:24
| Angucyclines from an insect-derived actinobacterium Amycolatopsis sp. HCa1 and their cytotoxic activity. |
| AID1638227 | Cytotoxicity against human A549/TAX cells after 72 hrs by MTT assay | 2019 | European journal of medicinal chemistry, Mar-01, Volume: 165 | Discovery and synthesis of sulfur-containing 6-substituted 5,8-dimethoxy-1,4-naphthoquinone oxime derivatives as new and potential anti-MDR cancer agents. |
| AID461181 | Antitumor activity against human HL60 cells | 2010 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 20, Issue:3
| Polar 3-alkylidene-5-pivaloyloxymethyl-5'-hydroxymethyl-gamma-lactones as protein kinase C ligands and antitumor agents. |
| AID1410126 | Growth inhibition of human HL60 cells measured after 3 days by trypan blue assay | 2018 | Journal of natural products, 04-27, Volume: 81, Issue:4
| Bioassay- and Chemistry-Guided Isolation of Scalemic Caged Prenylxanthones from the Leaves of Garcinia bracteata. |
| AID1437482 | Cytotoxicity against human HL60 cells assessed as reduction in cell viability by MTT assay | 2017 | Journal of natural products, 01-27, Volume: 80, Issue:1
| Penicisulfuranols A-F, Alkaloids from the Mangrove Endophytic Fungus Penicillium janthinellum HDN13-309. |
| AID1638230 | Selectivity ratio of IC50 for human A549 cells to IC50 for human A549/TAX cells | 2019 | European journal of medicinal chemistry, Mar-01, Volume: 165 | Discovery and synthesis of sulfur-containing 6-substituted 5,8-dimethoxy-1,4-naphthoquinone oxime derivatives as new and potential anti-MDR cancer agents. |
| AID1751133 | Cytotoxicity against human L02 cells assessed as reduction in cell viability by MTT assay | | | |
| AID1486952 | Inhibition of ABCB1 in human K562/A02 cells assessed as potentiation of adriamycin-induced cytotoxicity by measuring reduction in ADR IC50 at 5 uM measured after 48 hrs by MTT assay relative to ADR alone | 2017 | Bioorganic & medicinal chemistry, 08-01, Volume: 25, Issue:15
| Synthesis and biological evaluation of JL-A7 derivatives as potent ABCB1 inhibitors. |
| AID1706707 | Antiproliferative activity against human K562 cells assessed as reduction in cell viability by MTT assay | 2021 | European journal of medicinal chemistry, Jan-01, Volume: 209 | Discovery of lysosome-targeted covalent anticancer agents based on isosteviol skeleton. |
| AID1887100 | Cytotoxicity against human K562 cells assessed as reduction in cell viability by MTT assay | | | |
| AID1441109 | Cytotoxicity against human DU145 cells assessed as cell death at 2 to 25 times CC50 after 48 hrs by MTS assay | 2017 | Journal of medicinal chemistry, 03-09, Volume: 60, Issue:5
| Replacing d-Glucosamine with Its l-Enantiomer in Glycosylated Antitumor Ether Lipids (GAELs) Retains Cytotoxic Effects against Epithelial Cancer Cells and Cancer Stem Cells. |
| AID478275 | Induction of apoptosis in human 518A2 cells assessed as increase of caspase 8 activity at 5 uM measured up to 12 hrs by luminometric assay | 2010 | European journal of medicinal chemistry, May, Volume: 45, Issue:5
| Modulation of doxorubicin activity in cancer cells by conjugation with fatty acyl and terpenyl hydrazones. |
| AID1278416 | Cytotoxicity against human HL60 cells after 72 hrs by MTT assay | 2016 | Bioorganic & medicinal chemistry letters, Feb-15, Volume: 26, Issue:4
| Dispirocyclopropyldehydrocostus lactone selectively inhibits acute myelogenous leukemia cells. |
| AID1504837 | Cytotoxicity against human PC3 cells assessed as reduction in cell viability by MTT assay | 2017 | Journal of natural products, 12-22, Volume: 80, Issue:12
| Bibenzyl-Based Meroterpenoid Enantiomers from the Chinese Liverwort Radula sumatrana. |
| AID1490963 | Cytotoxicity against human HL60 cells after 72 hrs by MTT assay | 2017 | Journal of natural products, 05-26, Volume: 80, Issue:5
| Geranylpyrrol A and Piericidin F from Streptomyces sp. CHQ-64 ΔrdmF. |
| AID592934 | Cytotoxicity against human COLO205 cells by sulforhodamine B method | 2011 | Bioorganic & medicinal chemistry, Apr-15, Volume: 19, Issue:8
| Synthesis and biological evaluation of estradiol linked pyrrolo[2,1-c][1,4]benzodiazepine (PBD) conjugates as potential anticancer agents. |
| AID452682 | Cytotoxicity against human HCT116 cells after 3 days | 2010 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 20, Issue:1
| 2,6-Dithienyl-4-furyl pyridines: Synthesis, topoisomerase I and II inhibition, cytotoxicity, structure-activity relationship, and docking study. |
| AID1594688 | Cytotoxicity in human A549 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay | 2019 | Journal of natural products, 06-28, Volume: 82, Issue:6
| Asperunguisins A-F, Cytotoxic Asperane Sesterterpenoids from the Endolichenic Fungus Aspergillus unguis. |
| AID334279 | Antiproliferative activity against mouse 26-L5 cells after 72 hrs by MTT assay | 2002 | Journal of natural products, May, Volume: 65, Issue:5
| Constituents of Chinese propolis and their antiproliferative activities. |
| AID478257 | Cytotoxicity against human vinblastine-resistant KBV1 cells after 48 hrs by MTT assay | 2010 | European journal of medicinal chemistry, May, Volume: 45, Issue:5
| Modulation of doxorubicin activity in cancer cells by conjugation with fatty acyl and terpenyl hydrazones. |
| AID1163658 | Toxicity in human HepG2 cells xenografted Balb/C mouse assessed as body weight changes at 5 mg/kg, iv dosed every 2 days for 11 days | 2014 | Journal of medicinal chemistry, Oct-09, Volume: 57, Issue:19
| Synthesis and biological evaluation of novel millepachine derivatives as a new class of tubulin polymerization inhibitors. |
| AID55161 | Inhibition of [3H]thymidine incorporation into proliferating L1210 cells. | 1984 | Journal of medicinal chemistry, May, Volume: 27, Issue:5
| Intensely potent morpholinyl anthracyclines. |
| AID650183 | Cytotoxicity against human K562 cells after 48 hrs by MTT assay | 2012 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 22, Issue:5
| Synthesis and evaluation of cytotoxic effects of novel α-methylenelactone tetracyclic diterpenoids. |
| AID460541 | Cytotoxicity against human MDA-MB-231 cells after 48 hrs by MTT assay | 2010 | Bioorganic & medicinal chemistry, Feb, Volume: 18, Issue:3
| New benzoxanthone derivatives as topoisomerase inhibitors and DNA cross-linkers. |
| AID1546810 | Cytotoxicity against human U87 cells after 24 hrs by SRB method | 2020 | Journal of natural products, 01-24, Volume: 83, Issue:1
| Prenylated |
| AID1577632 | Antiproliferative activity against human HCC70 cells measured after 72 hrs by Ez-cytox assay | 2019 | Journal of medicinal chemistry, 09-12, Volume: 62, Issue:17
| Discovery and Biological Evaluations of Halogenated 2,4-Diphenyl Indeno[1,2- |
| AID1671739 | Antiproliferative activity against human SMMC-7721 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay | 2019 | European journal of medicinal chemistry, Mar-15, Volume: 166 | Excellent antitumor and antimetastatic activities based on novel coumarin/pyrazole oxime hybrids. |
| AID551373 | Cytotoxicity against human COLO205 assessed as inhibition of cell growth | 2011 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 21, Issue:1
| An efficient one-pot synthesis of benzothiazolo-4β-anilino-podophyllotoxin congeners: DNA topoisomerase-II inhibition and anticancer activity. |
| AID588213 | Literature-mined compound from Fourches et al multi-species drug-induced liver injury (DILI) dataset, effect in non-rodents | 2010 | Chemical research in toxicology, Jan, Volume: 23, Issue:1
| Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. |
| AID718783 | Cytotoxicity against human GHOST-R5X4 cells after 48 hrs by MTT assay | 2012 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 22, Issue:24
| Angucyclines from an insect-derived actinobacterium Amycolatopsis sp. HCa1 and their cytotoxic activity. |
| AID1663787 | Anticancer activity against human HepG2 cells assessed as inhibition of cell proliferation | 2020 | Bioorganic & medicinal chemistry letters, 07-15, Volume: 30, Issue:14
| Synthesis and evaluation of novel sulfonamide analogues of 6/7-aminoflavones as anticancer agents via topoisomerase II inhibition. |
| AID1851422 | Antiproliferative activity against human HeLa cells assessed as inhibition of cell growth | 2022 | Bioorganic & medicinal chemistry letters, 10-01, Volume: 73 | Synthesis and antitumor activity of a series of novel N-aryl-5-(2,2,2-trifluoroethoxy)-1,5-dihydro-2H-pyrrol-2-ones derivatives. |
| AID334278 | Antiproliferative activity against human HeLa cells after 72 hrs by MTT assay | 2002 | Journal of natural products, May, Volume: 65, Issue:5
| Constituents of Chinese propolis and their antiproliferative activities. |
| AID1905036 | Antiproliferative activity against human HCT-8 cells assessed as cell viability incubated for 48 hrs by MTT assay | 2022 | Journal of medicinal chemistry, 03-24, Volume: 65, Issue:6
| Discovery of a Novel Stilbene Derivative as a Microtubule Targeting Agent Capable of Inducing Cell Ferroptosis. |
| AID633820 | Cytotoxicity against human MCF7 cells after 24 hrs by MTT assay | 2012 | Bioorganic & medicinal chemistry, Jan-01, Volume: 20, Issue:1
| Synthesis, antiproliferative activity and genotoxicity of novel anthracene-containing aminophosphonates and a new anthracene-derived Schiff base. |
| AID1435969 | Cytotoxicity against human K562 cells assessed as growth inhibition at 10 uM measured after 72 hrs by CCK-8 assay relative to control | | | |
| AID592932 | Cytotoxicity against human Gurav cells by sulforhodamine B method | 2011 | Bioorganic & medicinal chemistry, Apr-15, Volume: 19, Issue:8
| Synthesis and biological evaluation of estradiol linked pyrrolo[2,1-c][1,4]benzodiazepine (PBD) conjugates as potential anticancer agents. |
| AID1894515 | Antitumor activity against mouse CCRF S-180 cells allografted in ICR mouse assessed as tumor growth inhibition at 0.1 micromol/kg, iv administered for 7 days relative to control | 2021 | European journal of medicinal chemistry, Apr-15, Volume: 216 | β-Carbolines as potential anticancer agents. |
| AID1637328 | Induction of apoptosis in human HeLa cells assessed as viable cells at 3 uM after 48 hrs by Annexin V/propidium iodide staining based flow cytometric analysis (Rvb = 46.00 +/- 0.56 %) | 2016 | Bioorganic & medicinal chemistry, 10-01, Volume: 24, Issue:19
| In vitro cytotoxicity of novel 2,5,7-tricarbo-substituted indoles derived from 2-amino-5-bromo-3-iodoacetophenone. |
| AID1164703 | Cytotoxicity against human A549 cells after 24 hrs by MTT assay | 2014 | Journal of natural products, Sep-26, Volume: 77, Issue:9
| Notolutesins A-J, dolabrane-type diterpenoids from the Chinese liverwort Notoscyphus lutescens. |
| AID1370453 | Drug localization in human HepG2 cell nucleus assessed as doxorubicin conjugates accumulation at 10 uM after 24 hrs by DAPI staining-based fluorescence microscopic analysis | 2018 | Bioorganic & medicinal chemistry letters, 02-01, Volume: 28, Issue:3
| Synthesis and biological evaluation of novel doxorubicin-containing ASGP-R-targeted drug-conjugates. |
| AID1668784 | Cytotoxicity against human MCF7 cells incubated for 48 hrs by MTT assay | 2020 | Journal of natural products, 05-22, Volume: 83, Issue:5
| Cytotoxic Heptaketides from the Endolichenic Fungus |
| AID1505071 | Cytotoxicity against human G3K cells after 72 hrs by MTT assay | 2018 | Journal of natural products, 01-26, Volume: 81, Issue:1
| Ophiobolins from the Mangrove Fungus Aspergillus ustus. |
| AID1386174 | Cytotoxicity against human A549 cells after 48 hrs by MTT assay | 2018 | Journal of natural products, 09-28, Volume: 81, Issue:9
| Cytotoxic p-Terphenyls from the Endolichenic Fungus Floricola striata. |
| AID1421553 | Antiproliferative activity against human HL60 cells assessed as inhibition of cell growth at 1 uM after 72 hrs by MTT assay relative to control | 2018 | European journal of medicinal chemistry, Oct-05, Volume: 158 | Four new antitumor metabolites isolated from a mutant 3-f-31 strain derived from Penicillium purpurogenum G59. |
| AID1815018 | Cytotoxicity against human A549 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay | 2021 | Journal of natural products, 08-27, Volume: 84, Issue:8
| Cryptoyunnanones A-H, Complex Flavanones from |
| AID1370450 | Drug uptake in human HepG2 cells assessed as doxorubicin conjugates accumulation at 10 uM after 6 hrs by fluorescence assay | 2018 | Bioorganic & medicinal chemistry letters, 02-01, Volume: 28, Issue:3
| Synthesis and biological evaluation of novel doxorubicin-containing ASGP-R-targeted drug-conjugates. |
| AID138194 | Compound was evaluated for antitumor activity in mice injected intraperitoneal with leukemia P-388 cells, treated on days 5, 9, and 13 th day at 8 mg/kg | 1981 | Journal of medicinal chemistry, Jun, Volume: 24, Issue:6
| Synthesis and preliminary antitumor evaluation of 5-iminodoxorubicin. |
| AID154432 | Cytotoxicity against PACA-2 cell line in the purdue cell culture screen was determined | 1999 | Bioorganic & medicinal chemistry letters, Feb-08, Volume: 9, Issue:3
| On the relationship of OSW-1 to the cephalostatins. |
| AID734494 | Growth inhibition against human HT-29 cells after 72 hrs by inverted microscopy | 2013 | European journal of medicinal chemistry, Apr, Volume: 62 | Synthesis, cytotoxicity and antiplasmodial activity of novel ent-kaurane derivatives. |
| AID1405496 | Therapeutic index, ratio of IC50 for human FHC cells to IC50 for human HCT116 cells | 2018 | European journal of medicinal chemistry, Aug-05, Volume: 156 | Copper(I) oxide nanoparticles catalyzed click chemistry based synthesis of melampomagnolide B-triazole conjugates and their anti-cancer activities. |
| AID1821806 | Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability after 48 hrs by MTT assay | 2022 | European journal of medicinal chemistry, Feb-05, Volume: 229 | Design and synthesis of marine sesterterpene analogues as novel estrogen receptor α degraders for breast cancer treatment. |
| AID1185778 | Growth inhibition of human PC3 cells at 10 uM after 72 hrs by MTT assay | 2014 | European journal of medicinal chemistry, Sep-12, Volume: 84 | Synthesis and biological evaluation of novel 6-chloro-quinazolin derivatives as potential antitumor agents. |
| AID1381568 | Cytotoxicity against human HepG2 cells by SRB assay | | | |
| AID1751127 | Cytotoxicity against human A-427 cells assessed as reduction in cell viability by MTT assay | | | |
| AID1505076 | Cytotoxicity against human HL60 cells after 72 hrs by MTT assay | 2018 | Journal of natural products, 01-26, Volume: 81, Issue:1
| Ophiobolins from the Mangrove Fungus Aspergillus ustus. |
| AID599174 | Cytotoxicity against human DU145 cells after 2 days | 2011 | European journal of medicinal chemistry, Jun, Volume: 46, Issue:6
| Synthesis, biological evaluation, and molecular docking study of 3-(3'-heteroatom substituted-2'-hydroxy-1'-propyloxy) xanthone analogues as novel topoisomerase IIα catalytic inhibitor. |
| AID1783257 | Cytotoxicity against human HepG2 cells assessed as inhibition rate at 2.5 uM incubated for 72 hrs by MTT assay relative to control | | | |
| AID1895012 | Anticancer activity against human HCT-116 cells assessed as inhibition of cell growth by MTT assay | 2021 | European journal of medicinal chemistry, Aug-05, Volume: 220 | Discovery of cytotoxic natural products from Red Sea sponges: Structure and synthesis. |
| AID122234 | Antitumor activity against mice bearing P388 leukemia implanted ip on day 0, after treatment with single iv dose 10 mg/kg on day 1. | 1984 | Journal of medicinal chemistry, May, Volume: 27, Issue:5
| Intensely potent morpholinyl anthracyclines. |
| AID1236897 | Cytotoxicity against human HeLa cells incubated from day 2 to day 4 by CCK8 assay | 2015 | Bioorganic & medicinal chemistry, Jul-01, Volume: 23, Issue:13
| Synthesis, topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship study of 2-phenyl- or hydroxylated 2-phenyl-4-aryl-5H-indeno[1,2-b]pyridines. |
| AID1428694 | Antiproliferative activity against human HeLa cells after 72 hrs by CCK8 assay | 2017 | European journal of medicinal chemistry, Feb-15, Volume: 127 | Rational design, synthesis, and evaluation of novel 2,4-Chloro- and Hydroxy-Substituted diphenyl Benzofuro[3,2-b]Pyridines: Non-intercalative catalytic topoisomerase I and II dual inhibitor. |
| AID1671755 | Inhibition of epithelial-mesenchymal transition in human SMMC-7721 cells assessed as increase in TGF-beta1 reduced E-cadherin expression at 0.5 uM incubated for 48 hrs by Western blot analysis | 2019 | European journal of medicinal chemistry, Mar-15, Volume: 166 | Excellent antitumor and antimetastatic activities based on novel coumarin/pyrazole oxime hybrids. |
| AID1543242 | Cytotoxicity in human A549 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay | 2019 | Journal of natural products, 07-26, Volume: 82, Issue:7
| Prenylated Bibenzyls from the Chinese Liverwort |
| AID697852 | Inhibition of electric eel AChE at 2 mg/ml by Ellman's method | 2012 | Bioorganic & medicinal chemistry, Nov-15, Volume: 20, Issue:22
| Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine. |
| AID1326554 | Antiproliferative activity against human ER-triple negative MDA-MB-468 cells measured after 48 hrs by MTT assay | 2016 | European journal of medicinal chemistry, Oct-21, Volume: 122 | Discovery and development of natural product oridonin-inspired anticancer agents. |
| AID736707 | Cytotoxicity against human MG63 cells by MTT assay | 2013 | Journal of natural products, Apr-26, Volume: 76, Issue:4
| Steroids glycosylated with both D- and L-arabinoses from the South China Sea gorgonian Dichotella gemmacea. |
| AID357612 | Antiproliferative activity against human HT1080 cells assessed as cell viability after 72 hrs by MTT assay | 2001 | Journal of natural products, Sep, Volume: 64, Issue:9
| New spirostanol steroids and steroidal saponins from roots and rhizomes of Dracaena angustifolia and their antiproliferative activity. |
| AID1441108 | Cytotoxicity against human MIAPaCa2 cells assessed as cell death at 2 to 25 times CC50 after 48 hrs by MTS assay | 2017 | Journal of medicinal chemistry, 03-09, Volume: 60, Issue:5
| Replacing d-Glucosamine with Its l-Enantiomer in Glycosylated Antitumor Ether Lipids (GAELs) Retains Cytotoxic Effects against Epithelial Cancer Cells and Cancer Stem Cells. |
| AID1672168 | Cytotoxicity against human HEK293 cells assessed as inhibition of cell proliferation after 48 hrs by MTT assay | 2019 | Bioorganic & medicinal chemistry, 04-01, Volume: 27, Issue:7
| Design and synthesis of various quinizarin derivatives as potential anticancer agents in acute T lymphoblastic leukemia. |
| AID1888034 | Antiproliferative activity against human HeLa cells after 72 hrs by EZ-Cytox colorimetric assay | 2022 | European journal of medicinal chemistry, Jan-05, Volume: 227 | Identification of new halogen-containing 2,4-diphenyl indenopyridin-5-one derivative as a boosting agent for the anticancer responses of clinically available topoisomerase inhibitors. |
| AID1272408 | Antiproliferative activity against human MCF7 cells after 96 hrs by MTT assay | 2016 | European journal of medicinal chemistry, Jan-27, Volume: 108 | Combating P-glycoprotein-mediated multidrug resistance with 10-O-phenyl dihydroartemisinin ethers in MCF-7 cells. |
| AID1776431 | Cytotoxicity against human MCF-7 cells assessed as cell viability inhibition for 48 hrs by MTT assay | 2021 | Journal of natural products, 05-28, Volume: 84, Issue:5
| Diverse Prenylated Bibenzyl Enantiomers from the Chinese Liverwort |
| AID1330741 | Cytotoxicity against human HCT15 cells assessed as reduction in cell growth after 72 hrs by CCK8 assay | 2016 | European journal of medicinal chemistry, Nov-10, Volume: 123 | Synthesis and biological evaluation of C1-O-substituted-3-(3-butylamino-2-hydroxy-propoxy)-xanthen-9-one as topoisomerase IIα catalytic inhibitors. |
| AID1180308 | Cytotoxicity against human MCF7 cells by SRB method | 2014 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 24, Issue:15
| One pot three components microwave assisted and conventional synthesis of new 3-(4-chloro-2-hydroxyphenyl)-2-(substituted) thiazolidin-4-one as antimicrobial agents. |
| AID1887101 | Cytotoxicity against human L02 cells assessed as reduction in cell viability by SRB assay | | | |
| AID1185755 | Cytotoxicity against normal human PBMC assessed as reduction in cell viability at 10 times anti-leukemic IC50 after 48 hrs by Alamar blue assay | 2014 | European journal of medicinal chemistry, 09-12, Volume: 84 | Synthesis and evaluation of the cytotoxic activity of 1,2-furanonaphthoquinones tethered to 1,2,3-1H-triazoles in myeloid and lymphoid leukemia cell lines. |
| AID510627 | Cytotoxicity against human DU145 cells after 4 days by MTT assay | 2010 | European journal of medicinal chemistry, Sep, Volume: 45, Issue:9
| Synthesis and pharmacological evaluation of new methyloxiranylmethoxyxanthone analogues. |
| AID595894 | Cytotoxicity against human NCI-H187 cells after 45 hrs by resazurin microplate assay | 2011 | Journal of natural products, Apr-25, Volume: 74, Issue:4
| Bioactive compounds from the scale insect pathogenic fungus Conoideocrella tenuis BCC 18627. |
| AID1278450 | Selectivity index, ratio IC50 for human HL60 cells to IC50 for human HL60/ADR cells | 2016 | Bioorganic & medicinal chemistry letters, Feb-15, Volume: 26, Issue:4
| Dispirocyclopropyldehydrocostus lactone selectively inhibits acute myelogenous leukemia cells. |
| AID478305 | Cytotoxicity against human 518A2 cells assessed as increase in ROS production at 5 uM after 24 hrs by NBT reduction assay relative to control | 2010 | European journal of medicinal chemistry, May, Volume: 45, Issue:5
| Modulation of doxorubicin activity in cancer cells by conjugation with fatty acyl and terpenyl hydrazones. |
| AID1126889 | Cytotoxicity against human A549 cells assessed as cell viability after 72 hrs by SRB assay | 2014 | European journal of medicinal chemistry, May-06, Volume: 78 | Synthesis and in vitro cytotoxic effect of 6-amino-substituted 11H- and 11Me-indolo[3,2-c]quinolines. |
| AID1508157 | Cell cycle arrest in human MCF7 cells assessed as accumulation at G0/G1 phase at 2 uM after 48 hrs by flow cytometric analysis (Rvb = 34.2%) | 2017 | European journal of medicinal chemistry, Oct-20, Volume: 139 | Design, synthesis and biological evaluation of novel pyrazolochalcones as potential modulators of PI3K/Akt/mTOR pathway and inducers of apoptosis in breast cancer cells. |
| AID1435967 | Cytotoxicity against human Jurkat cells assessed as growth inhibition at 10 uM measured after 72 hrs by CCK-8 assay relative to control | | | |
| AID1543247 | Cytotoxicity in human U251 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay | 2019 | Journal of natural products, 07-26, Volume: 82, Issue:7
| Prenylated Bibenzyls from the Chinese Liverwort |
| AID673201 | Antiproliferative activity against human HCT116 cells after 72 hrs by SRB assay | 2012 | Bioorganic & medicinal chemistry, Aug-01, Volume: 20, Issue:15
| Synthesis and in vitro antiproliferative activity of new 11-aminoalkylamino-substituted 5H- and 6H-indolo[2,3-b]quinolines; structure-activity relationships of neocryptolepines and 6-methyl congeners. |
| AID1132910 | Partition coefficient, log P of the compound | 1978 | Journal of medicinal chemistry, Aug, Volume: 21, Issue:8
| Antitumor anthracycline antibiotics. Structure-activity and structure-cardiotoxicity relationships of rubidazone analogues. |
| AID1882811 | Antitumor activity against mouse Sarcoma-180 cells xenografted in ip dosed ICR mouse assessed as tumor growth inhibition rate administered daily for 5 days relative to control | 2022 | European journal of medicinal chemistry, May-05, Volume: 235 | Recent advances of antitumor shikonin/alkannin derivatives: A comprehensive overview focusing on structural classification, synthetic approaches, and mechanisms of action. |
| AID1126867 | Cytotoxicity against human A549 cells assessed as growth inhibition after 72 hrs by SRB assay | 2014 | European journal of medicinal chemistry, May-06, Volume: 78 | Searching for new derivatives of neocryptolepine: synthesis, antiproliferative, antimicrobial and antifungal activities. |
| AID23283 | Partition coefficient (log P) was the log of ratio of concentration in octanol / water partitioned concentration in phosphate buffer at pH 7.4. | 1984 | Journal of medicinal chemistry, May, Volume: 27, Issue:5
| Intensely potent morpholinyl anthracyclines. |
| AID378843 | Cytotoxicity against human Hep G2 cells | 2006 | Journal of natural products, Oct, Volume: 69, Issue:10
| Bioactive guaianolides from siyekucai (Ixeris chinensis). |
| AID1439746 | Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay | 2017 | Bioorganic & medicinal chemistry letters, 04-01, Volume: 27, Issue:7
| Synthesis of extended conjugated indolyl chalcones as potent anti-breast cancer, anti-inflammatory and antioxidant agents. |
| AID1706710 | Antiproliferative activity against human HCC1428 cells assessed as reduction in cell viability by MTT assay | 2021 | European journal of medicinal chemistry, Jan-01, Volume: 209 | Discovery of lysosome-targeted covalent anticancer agents based on isosteviol skeleton. |
| AID1308425 | Cytotoxicity in rat H9c2 cells assessed as intracellular ROS accumulation at 5 uM incubated for 24 hrs in presence of hydroxocobalamin by DCFDA-AM probe-based fluorimetrical analysis relative to control | 2016 | Journal of medicinal chemistry, 05-26, Volume: 59, Issue:10
| H2S-Donating Doxorubicins May Overcome Cardiotoxicity and Multidrug Resistance. |
| AID1524534 | Resistance index, ratio of IC50 for human MCF7/ADR cells to IC50 for human MCF7 cells | | | |
| AID1410127 | Growth inhibition of human K562 cells measured after 3 days by trypan blue assay | 2018 | Journal of natural products, 04-27, Volume: 81, Issue:4
| Bioassay- and Chemistry-Guided Isolation of Scalemic Caged Prenylxanthones from the Leaves of Garcinia bracteata. |
| AID467759 | Cytotoxicity against human HT-29 cells by MTT assay | 2009 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 19, Issue:23
| Oxiranylmethyloxy or thiiranylmethyloxy-azaxanthones and -acridone analogues as potential topoisomerase I inhibitors. |
| AID221147 | Thermal denaturation for stabilization of helical DNA by the compound | 1981 | Journal of medicinal chemistry, Jun, Volume: 24, Issue:6
| Synthesis and preliminary antitumor evaluation of 5-iminodoxorubicin. |
| AID1188100 | Cytotoxicity against human COLO205 cells assessed as growth inhibition at 1 uM after 48 hrs by sulforhodamine B assay | 2014 | European journal of medicinal chemistry, Oct-06, Volume: 85 | Chalcone based azacarboline analogues as novel antitubulin agents: design, synthesis, biological evaluation and molecular modelling studies. |
| AID1757280 | Antiproliferative activity against ADR-resistant human Bel-7402 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay | 2021 | European journal of medicinal chemistry, Apr-15, Volume: 216 | Discovery of novel N-benzylbenzamide derivatives as tubulin polymerization inhibitors with potent antitumor activities. |
| AID1490965 | Cytotoxicity against human K562 cells after 72 hrs by MTT assay | 2017 | Journal of natural products, 05-26, Volume: 80, Issue:5
| Geranylpyrrol A and Piericidin F from Streptomyces sp. CHQ-64 ΔrdmF. |
| AID1871293 | Cytotoxicity against human A549 cells assessed as cell growth inhibition | 2021 | European journal of medicinal chemistry, Jan-15, Volume: 210 | Renieramycin-type alkaloids from marine-derived organisms: Synthetic chemistry, biological activity and structural modification. |
| AID1583357 | Antiproliferative activity against human U87 cells assessed as reduction in cell viability after 72 hrs by MTT assay | 2020 | Journal of medicinal chemistry, 02-27, Volume: 63, Issue:4
| Identification of Parthenolide Dimers as Activators of Pyruvate Kinase M2 in Xenografts of Glioblastoma Multiforme in Vivo. |
| AID1612613 | Antiproliferative activity against human HCT8 cells after 72 hrs by MTT assay | 2019 | European journal of medicinal chemistry, Feb-01, Volume: 163 | Design, synthesis and biological evaluation of quinoline-indole derivatives as anti-tubulin agents targeting the colchicine binding site. |
| AID566858 | Cytotoxicity against human MCF7 cells at 10 uM after 48 hrs by MTT assay | 2010 | Journal of natural products, Dec-27, Volume: 73, Issue:12
| Cytotoxic triterpenoids from Maytenus retusa. |
| AID467758 | Cytotoxicity against human HeLa cells by MTT assay | 2009 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 19, Issue:23
| Oxiranylmethyloxy or thiiranylmethyloxy-azaxanthones and -acridone analogues as potential topoisomerase I inhibitors. |
| AID1638225 | Cytotoxicity against human MCF7/ADR cells after 72 hrs by MTT assay | 2019 | European journal of medicinal chemistry, Mar-01, Volume: 165 | Discovery and synthesis of sulfur-containing 6-substituted 5,8-dimethoxy-1,4-naphthoquinone oxime derivatives as new and potential anti-MDR cancer agents. |
| AID1751126 | Cytotoxicity against human A549 cells assessed as reduction in cell viability by MTT assay | | | |
| AID490205 | Cytotoxicity against human A375 cells by MTT assay | 2010 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 20, Issue:13
| Synthesis of novel beta-carbolines with efficient DNA-binding capacity and potent cytotoxicity. |
| AID619898 | Cytotoxicity against human 22Rv1 cells by MTT assay | 2011 | European journal of medicinal chemistry, Oct, Volume: 46, Issue:10
| Synthesis and biological evaluation of 1,9-disubstituted β-carbolines as potent DNA intercalating and cytotoxic agents. |
| AID1546804 | Cytotoxicity against human MGC803 cells after 24 hrs by SRB method | 2020 | Journal of natural products, 01-24, Volume: 83, Issue:1
| Prenylated |
| AID1486761 | Antiproliferative activity against human HeLa cells after 72 hrs by CCK8 assay | 2017 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 27, Issue:15
| 2-Chlorophenyl-substituted benzofuro[3,2-b]pyridines with enhanced topoisomerase inhibitory activity: The role of the chlorine substituent. |
| AID1890790 | Cytotoxicity against human NUGC-3 cells assessed as cell growth inhibition incubated for 48 hrs by SRB method | 2022 | Journal of natural products, 04-22, Volume: 85, Issue:4
| Isolation, Structure Determination, and Semisynthesis of Diphenazine Compounds from a Deep-Sea-Derived Strain of the Fungus |
| AID1762254 | Cytotoxicity against human HT-1080 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay | | | |
| AID1277893 | Cytotoxicity against human HCT116 cells assessed as cell viability after 48 hrs by MTT assay | 2016 | Bioorganic & medicinal chemistry letters, Feb-15, Volume: 26, Issue:4
| Structure activity relationship, cytotoxicity and evaluation of antioxidant activity of curcumin derivatives. |
| AID1352063 | Cytotoxicity against human K562 cells assessed as reduction in cell viability after 72 hrs by MTS assay | 2018 | European journal of medicinal chemistry, Feb-10, Volume: 145 | Synthesis and biological evaluation of bifendate derivatives bearing 6,7-dihydro-dibenzo[c,e]azepine scaffold as potential P-glycoprotein and tumor metastasis inhibitors. |
| AID376374 | Antitumor activity against human A549 cells | 1999 | Journal of natural products, Nov, Volume: 62, Issue:11
| Synthesis of 11,12-epoxydrim-8,12-en-11-ol, 11,12-diacetoxydrimane, and warburganal from (-)-sclareol. |
| AID1426669 | Antitumor activity against P-gp overexpressing/drug resistant human K562/A02 cells xenografted in BALB/c nude mouse assessed as reduction in tumor weight at 4 mg/kg, iv administered every other day for 21 days measured post last dose | 2017 | Journal of medicinal chemistry, 02-09, Volume: 60, Issue:3
| Potent Inhibition of Nitric Oxide-Releasing Bifendate Derivatives against Drug-Resistant K562/A02 Cells in Vitro and in Vivo. |
| AID1637344 | Cytotoxicity against human MCF7 cells assessed as cell viability at 0.5 uM after 2 days by MTT assay relative to control | 2016 | Bioorganic & medicinal chemistry, 10-01, Volume: 24, Issue:19
| In vitro cytotoxicity of novel 2,5,7-tricarbo-substituted indoles derived from 2-amino-5-bromo-3-iodoacetophenone. |
| AID1355286 | Cytotoxicity against human ACHN cells assessed as inhibition of cell proliferation measured after 72 hrs by sulforhodamine B assay | 2018 | Journal of natural products, 06-22, Volume: 81, Issue:6
| Cytotoxic Drimane Sesquiterpenoids Isolated from Perenniporia maackiae. |
| AID1504776 | Cytotoxicity against human KB cells by SRB assay | 2017 | Journal of natural products, 12-22, Volume: 80, Issue:12
| Cephanolides A-J, Cephalotane-Type Diterpenoids from Cephalotaxus sinensis. |
| AID588211 | Literature-mined compound from Fourches et al multi-species drug-induced liver injury (DILI) dataset, effect in humans | 2010 | Chemical research in toxicology, Jan, Volume: 23, Issue:1
| Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. |
| AID478006 | Antiproliferative activity against human MCF7 cells after 72 hrs by sulforhodamine B assay | 2010 | Journal of medicinal chemistry, Apr-22, Volume: 53, Issue:8
| A series of alpha-heterocyclic carboxaldehyde thiosemicarbazones inhibit topoisomerase IIalpha catalytic activity. |
| AID1132909 | Inhibition of RNA synthesis in mouse L1210 cells | 1978 | Journal of medicinal chemistry, Aug, Volume: 21, Issue:8
| Antitumor anthracycline antibiotics. Structure-activity and structure-cardiotoxicity relationships of rubidazone analogues. |
| AID1355996 | Cytotoxicity against human K562 cells after 72 hrs by MTT assay | 2018 | Journal of natural products, 07-27, Volume: 81, Issue:7
| Aniline-Tetramic Acids from the Deep-Sea-Derived Fungus Cladosporium sphaerospermum L3P3 Cultured with the HDAC Inhibitor SAHA. |
| AID1318829 | Cytotoxicity against human QG56 cells assessed as decrease in cell viability after 48 hrs by MTT assay | 2016 | European journal of medicinal chemistry, Oct-04, Volume: 121 | Design, structure activity relationship, cytotoxicity and evaluation of antioxidant activity of curcumin derivatives/analogues. |
| AID1337589 | Antiproliferative activity against human MCF7 cells measured after 72 hrs by CCK8 assay | 2017 | European journal of medicinal chemistry, Jan-05, Volume: 125 | Fluorescein hydrazones: A series of novel non-intercalative topoisomerase IIα catalytic inhibitors induce G1 arrest and apoptosis in breast and colon cancer cells. |
| AID1696719 | Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability after 48 hrs by SRB assay | 2020 | Journal of natural products, 09-25, Volume: 83, Issue:9
| Dimeric Tetrahydroanthracene Regioisomers and Their Monomeric Precursor Produced by |
| AID650181 | Cytotoxicity against human HCT116 cells after 48 hrs by MTT assay | 2012 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 22, Issue:5
| Synthesis and evaluation of cytotoxic effects of novel α-methylenelactone tetracyclic diterpenoids. |
| AID1851421 | Antiproliferative activity against human A549 cells assessed as inhibition of cell growth | 2022 | Bioorganic & medicinal chemistry letters, 10-01, Volume: 73 | Synthesis and antitumor activity of a series of novel N-aryl-5-(2,2,2-trifluoroethoxy)-1,5-dihydro-2H-pyrrol-2-ones derivatives. |
| AID1163665 | Toxicity in human HepG2 cells xenografted Balb/C mouse assessed as mortality level at 5 mg/kg, iv dosed every 2 days for 11 days | 2014 | Journal of medicinal chemistry, Oct-09, Volume: 57, Issue:19
| Synthesis and biological evaluation of novel millepachine derivatives as a new class of tubulin polymerization inhibitors. |
| AID461388 | Antitumor activity against human Hs 578T cells | 2010 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 20, Issue:3
| Polar 3-alkylidene-5-pivaloyloxymethyl-5'-hydroxymethyl-gamma-lactones as protein kinase C ligands and antitumor agents. |
| AID592935 | Cytotoxicity against human DWD cells by sulforhodamine B method | 2011 | Bioorganic & medicinal chemistry, Apr-15, Volume: 19, Issue:8
| Synthesis and biological evaluation of estradiol linked pyrrolo[2,1-c][1,4]benzodiazepine (PBD) conjugates as potential anticancer agents. |
| AID1126869 | Cytotoxicity against human LoVo cells assessed as growth inhibition after 72 hrs by SRB assay | 2014 | European journal of medicinal chemistry, May-06, Volume: 78 | Searching for new derivatives of neocryptolepine: synthesis, antiproliferative, antimicrobial and antifungal activities. |
| AID1426668 | Antitumor activity against P-gp overexpressing/drug resistant human K562/A02 cells xenografted in BALB/c nude mouse assessed as reduction in tumor size at 4 mg/kg, iv administered every other day for 21 days measured post last dose | 2017 | Journal of medicinal chemistry, 02-09, Volume: 60, Issue:3
| Potent Inhibition of Nitric Oxide-Releasing Bifendate Derivatives against Drug-Resistant K562/A02 Cells in Vitro and in Vivo. |
| AID1821805 | Resistance index, ratio of IC50 for antiproliferative activity against human MCF7/ADR cells to IC50 for antiproliferative activity against human MCF7 cells | 2022 | European journal of medicinal chemistry, Feb-05, Volume: 229 | Design and synthesis of marine sesterterpene analogues as novel estrogen receptor α degraders for breast cancer treatment. |
| AID1421560 | Antiproliferative activity against human PANC1 cells assessed as inhibition of cell growth at 1 uM after 72 hrs by sulforhodamine B assay relative to control | 2018 | European journal of medicinal chemistry, Oct-05, Volume: 158 | Four new antitumor metabolites isolated from a mutant 3-f-31 strain derived from Penicillium purpurogenum G59. |
| AID1546811 | Cytotoxicity against human K562 cells after 72 hrs by MTT assay | 2020 | Journal of natural products, 01-24, Volume: 83, Issue:1
| Prenylated |
| AID1517674 | Antiproliferative activity against human Bel7402/5-FU incubated for 72 hrs by MTT assay | 2019 | European journal of medicinal chemistry, Dec-01, Volume: 183 | Design and synthesis of parthenolide and 5-fluorouracil conjugates as potential anticancer agents against drug resistant hepatocellular carcinoma. |
| AID699782 | Growth inhibition of human HT-29 cells after 72 hrs by SRB assay | 2012 | Journal of medicinal chemistry, Aug-09, Volume: 55, Issue:15
| Synthesis and antimitotic and tubulin interaction profiles of novel pinacol derivatives of podophyllotoxins. |
| AID1431558 | Cytotoxicity against human KG1a cells assessed as decrease in cell proliferation after 48 hrs by MTT assay | 2017 | European journal of medicinal chemistry, Feb-15, Volume: 127 | Synthesis and anti-acute myeloid leukemia activity of C-14 modified parthenolide derivatives. |
| AID1378627 | Cytotoxicity against human HeLa cells after 72 hrs by MTT assay | 2017 | Journal of natural products, 08-25, Volume: 80, Issue:8
| Antifungal and Cytotoxic β-Resorcylic Acid Lactones from a Paecilomyces Species. |
| AID718785 | Cytotoxicity against human A375 cells after 48 hrs by MTT assay | 2012 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 22, Issue:24
| Angucyclines from an insect-derived actinobacterium Amycolatopsis sp. HCa1 and their cytotoxic activity. |
| AID1754633 | Cytotoxicity against human HeLa cells assessed as reduction in cell viability after 72 hrs by MTT assay | | | |
| AID599175 | Cytotoxicity against human MDA-MB-231 cells after 2 days | 2011 | European journal of medicinal chemistry, Jun, Volume: 46, Issue:6
| Synthesis, biological evaluation, and molecular docking study of 3-(3'-heteroatom substituted-2'-hydroxy-1'-propyloxy) xanthone analogues as novel topoisomerase IIα catalytic inhibitor. |
| AID1441898 | Antiproliferative activity against paclitaxel-resistant human PC3 cells after 48 hrs by MTT assay | 2017 | European journal of medicinal chemistry, Mar-31, Volume: 129 | Design, synthesis, biological evaluation and molecular modeling study of novel macrocyclic bisbibenzyl analogues as antitubulin agents. |
| AID490209 | Cytotoxicity against human MCF7 cells by MTT assay | 2010 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 20, Issue:13
| Synthesis of novel beta-carbolines with efficient DNA-binding capacity and potent cytotoxicity. |
| AID1489128 | Cytotoxicity against human PC3 cells assessed as reduction in cell viability after 24 hrs by CCK-8 assay | 2017 | Bioorganic & medicinal chemistry letters, 09-01, Volume: 27, Issue:17
| Discovery of novel 4(1H)-quinolone derivatives as potential antiproliferative and apoptosis inducing agents. |
| AID333315 | Cytotoxicity against human doxorubicin-resistant LoVo cells after 72 hrs by MTT assay | 2004 | Journal of natural products, Sep, Volume: 67, Issue:9
| Cytotoxic constituents of roots of Chaerophyllum hirsutum. |
| AID1428414 | Cytotoxicity against human HCT15 cells assessed as growth inhibition after 72 hrs by SRB assay | | | |
| AID1426655 | Anti-proliferative activity against P-gp overexpressing/drug resistant human K562/A02 cells measured after 72 hrs by MTS assay | 2017 | Journal of medicinal chemistry, 02-09, Volume: 60, Issue:3
| Potent Inhibition of Nitric Oxide-Releasing Bifendate Derivatives against Drug-Resistant K562/A02 Cells in Vitro and in Vivo. |
| AID1163672 | Antitumor activity against human HepG2 cells xenografted in Balb/C mouse assessed as tumor mass changes at 5 mg/kg, iv dosed every 2 days for 11 days | 2014 | Journal of medicinal chemistry, Oct-09, Volume: 57, Issue:19
| Synthesis and biological evaluation of novel millepachine derivatives as a new class of tubulin polymerization inhibitors. |
| AID478016 | Antiproliferative activity against human KB cells after 72 hrs by sulforhodamine B assay | 2010 | Journal of medicinal chemistry, Apr-22, Volume: 53, Issue:8
| A series of alpha-heterocyclic carboxaldehyde thiosemicarbazones inhibit topoisomerase IIalpha catalytic activity. |
| AID1421558 | Antiproliferative activity against human PC3 cells assessed as inhibition of cell growth at 1 uM after 72 hrs by sulforhodamine B assay relative to control | 2018 | European journal of medicinal chemistry, Oct-05, Volume: 158 | Four new antitumor metabolites isolated from a mutant 3-f-31 strain derived from Penicillium purpurogenum G59. |
| AID467761 | Cytotoxicity against human MDA-MB-231 cells by MTT assay | 2009 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 19, Issue:23
| Oxiranylmethyloxy or thiiranylmethyloxy-azaxanthones and -acridone analogues as potential topoisomerase I inhibitors. |
| AID484655 | Cytotoxicity against human A549 cells after 48 hrs by SRB assay | 2010 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 20, Issue:11
| Synthesis, anticancer activity and apoptosis inducing ability of anthranilamide-PBD conjugates. |
| AID509771 | Reversal of P-gp-mediated multidrug-resistance in human KB/VCR cells assessed as increase in intracellular adriamycin accumulation at 8 uM after 1 hr by flow cytometry relative to control | 2010 | Bioorganic & medicinal chemistry, Sep-15, Volume: 18, Issue:18
| Bisbibenzyl derivatives sensitize vincristine-resistant KB/VCR cells to chemotherapeutic agents by retarding P-gp activity. |
| AID1236894 | Cytotoxicity against human HCT15 cells incubated from day 2 to day 4 by CCK8 assay | 2015 | Bioorganic & medicinal chemistry, Jul-01, Volume: 23, Issue:13
| Synthesis, topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship study of 2-phenyl- or hydroxylated 2-phenyl-4-aryl-5H-indeno[1,2-b]pyridines. |
| AID1524005 | Cytotoxicity against mouse 3T3 cells measured after 72 hrs by MTT assay | 2019 | European journal of medicinal chemistry, Mar-15, Volume: 166 | Synthesis and structure-activity relationship studies of parthenolide derivatives as potential anti-triple negative breast cancer agents. |
| AID1057308 | Growth inhibition of human MCF10A cells after 72 hrs by CellTiter-Blue assay | 2013 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 23, Issue:24
| Design, synthesis and in vitro anticancer evaluation of 4,6-diamino-1,3,5-triazine-2-carbohydrazides and -carboxamides. |
| AID1132908 | Inhibition of DNA synthesis in mouse L1210 cells | 1978 | Journal of medicinal chemistry, Aug, Volume: 21, Issue:8
| Antitumor anthracycline antibiotics. Structure-activity and structure-cardiotoxicity relationships of rubidazone analogues. |
| AID1768122 | Cytotoxicity against human HeLa cells assessed as cell growth inhibition measured after 48 hrs by MTT assay | 2021 | Journal of natural products, 07-23, Volume: 84, Issue:7
| Iridoid Constituents of |
| AID1525108 | Cytotoxicity against human LO2 cells assessed as reduction in cell viability by MTT assay | 2019 | Journal of natural products, 05-24, Volume: 82, Issue:5
| Strepantibins A-C: Hexokinase II Inhibitors from a Mud Dauber Wasp Associated Streptomyces sp. |
| AID1508158 | Cell cycle arrest in human MCF7 cells assessed as accumulation at S phase at 2 uM after 48 hrs by flow cytometric analysis (Rvb = 57.7%) | 2017 | European journal of medicinal chemistry, Oct-20, Volume: 139 | Design, synthesis and biological evaluation of novel pyrazolochalcones as potential modulators of PI3K/Akt/mTOR pathway and inducers of apoptosis in breast cancer cells. |
| AID1899068 | Antiproliferative activity against human KB cells measured after 72 hrs by SRB assay | | | |
| AID1637351 | Cytotoxicity against human HeLa cells assessed as cell viability at 1 uM after 2 days by MTT assay relative to control | 2016 | Bioorganic & medicinal chemistry, 10-01, Volume: 24, Issue:19
| In vitro cytotoxicity of novel 2,5,7-tricarbo-substituted indoles derived from 2-amino-5-bromo-3-iodoacetophenone. |
| AID1697199 | Cytotoxicity against human NCI-H23 cells by colorimetric method | 2020 | Bioorganic & medicinal chemistry letters, 11-15, Volume: 30, Issue:22
| Design, synthesis and evaluation of novel indirubin-based N-hydroxybenzamides, N-hydroxypropenamides and N-hydroxyheptanamides as histone deacetylase inhibitors and antitumor agents. |
| AID480108 | Cytotoxicity against human HeLa cells after 2 days by automatic ELISA reader system | 2010 | Bioorganic & medicinal chemistry, May-01, Volume: 18, Issue:9
| Synthesis, topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship study of hydroxylated 2,4-diphenyl-6-aryl pyridines. |
| AID1308411 | Cytotoxicity in rat H9c2 cells at 5 uM incubated for 24 hrs by LDH release-based spectrofluorimetrical analysis relative to control | 2016 | Journal of medicinal chemistry, 05-26, Volume: 59, Issue:10
| H2S-Donating Doxorubicins May Overcome Cardiotoxicity and Multidrug Resistance. |
| AID1423926 | Cytotoxicity against human NCI-H460 cells assessed as inhibition of growth incubated for 72 hrs by MTT assay | 2017 | Journal of natural products, 04-28, Volume: 80, Issue:4
| Cytotoxic Fusicoccane-Type Diterpenoids from Streptomyces violascens Isolated from Ailuropoda melanoleuca Feces. |
| AID1821804 | Antiproliferative activity against human MCF7/ADR cells assessed as reduction in cell viability after 48 hrs by MTT assay | 2022 | European journal of medicinal chemistry, Feb-05, Volume: 229 | Design and synthesis of marine sesterterpene analogues as novel estrogen receptor α degraders for breast cancer treatment. |
| AID1625723 | Antiproliferative activity against human MCF7 cells after 24 hrs by MTT assay | 2016 | Journal of medicinal chemistry, 06-23, Volume: 59, Issue:12
| Design, Synthesis, and Evaluation of in Vitro and in Vivo Anticancer Activity of 4-Substituted Coumarins: A Novel Class of Potent Tubulin Polymerization Inhibitors. |
| AID1489126 | Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 24 hrs by CCK-8 assay | 2017 | Bioorganic & medicinal chemistry letters, 09-01, Volume: 27, Issue:17
| Discovery of novel 4(1H)-quinolone derivatives as potential antiproliferative and apoptosis inducing agents. |
| AID1875130 | Growth inhibition of human NUGC-3 cells by SRB assay | 2022 | Journal of natural products, 09-23, Volume: 85, Issue:9
| Aspersterols A-D, Ergostane-Type Sterols with an Unusual Unsaturated Side Chain from the Deep-Sea-Derived Fungus |
| AID1132916 | In vivo antitumor activity against mouse P388 cells allografted in BDF/CDF mouse assessed as host survival time at 1 mg/kg, ip administered on days 1 to 9 relative to control | 1978 | Journal of medicinal chemistry, Aug, Volume: 21, Issue:8
| Antitumor anthracycline antibiotics. Structure-activity and structure-cardiotoxicity relationships of rubidazone analogues. |
| AID1288091 | Cytotoxicity against human DU145 cells after 48 hrs by CCK8 assay | 2016 | European journal of medicinal chemistry, May-04, Volume: 113 | A new series of 2-phenol-4-aryl-6-chlorophenyl pyridine derivatives as dual topoisomerase I/II inhibitors: Synthesis, biological evaluation and 3D-QSAR study. |
| AID478270 | Induction of apoptosis in human HL60 cells assessed as increase of caspase 3 activity at 5 uM after 4 hrs by luminometric assay | 2010 | European journal of medicinal chemistry, May, Volume: 45, Issue:5
| Modulation of doxorubicin activity in cancer cells by conjugation with fatty acyl and terpenyl hydrazones. |
| AID1879218 | Antiproliferative activity against human T47D cells assessed as inhibition of cell proliferation | 2022 | Bioorganic & medicinal chemistry letters, 03-15, Volume: 60 | Topoisomerase IIα inhibitory and antiproliferative activity of dihydroxylated 2,6-diphenyl-4-fluorophenylpyridines: Design, synthesis, and structure-activity relationships. |
| AID1278451 | Selectivity index, ratio IC50 for human KG1a cells to IC50 for human HL60 cells | 2016 | Bioorganic & medicinal chemistry letters, Feb-15, Volume: 26, Issue:4
| Dispirocyclopropyldehydrocostus lactone selectively inhibits acute myelogenous leukemia cells. |
| AID1423928 | Cytotoxicity against human HeLa cells assessed as inhibition of growth incubated for 72 hrs by MTT assay | 2017 | Journal of natural products, 04-28, Volume: 80, Issue:4
| Cytotoxic Fusicoccane-Type Diterpenoids from Streptomyces violascens Isolated from Ailuropoda melanoleuca Feces. |
| AID699781 | Growth inhibition of human A549 cells after 72 hrs by SRB assay | 2012 | Journal of medicinal chemistry, Aug-09, Volume: 55, Issue:15
| Synthesis and antimitotic and tubulin interaction profiles of novel pinacol derivatives of podophyllotoxins. |
| AID1430411 | Cytotoxicity against human HeLa cells assessed as cell growth at 10'-7 M after 48 hrs by SRB assay relative to control | 2017 | Bioorganic & medicinal chemistry letters, 03-01, Volume: 27, Issue:5
| Methylsulfonyl benzothiazoles (MSBT) derivatives: Search for new potential antimicrobial and anticancer agents. |
| AID1404432 | Cytotoxicity against human A549 cells assessed as decrease in cell viability by MTT assay | 2018 | Journal of natural products, 04-27, Volume: 81, Issue:4
| Penicilindoles A-C, Cytotoxic Indole Diterpenes from the Mangrove-Derived Fungus Eupenicillium sp. HJ002. |
| AID592926 | Cytotoxicity against human ZR-75-1 cells by sulforhodamine B method | 2011 | Bioorganic & medicinal chemistry, Apr-15, Volume: 19, Issue:8
| Synthesis and biological evaluation of estradiol linked pyrrolo[2,1-c][1,4]benzodiazepine (PBD) conjugates as potential anticancer agents. |
| AID1359659 | Resistance index, ratio of IC50 for human MCF7/ADR cells to IC50 for human MCF7 cells | 2018 | European journal of medicinal chemistry, May-25, Volume: 152 | Discovery of novel β-carboline/acylhydrazone hybrids as potent antitumor agents and overcome drug resistance. |
| AID1132921 | Cardiotoxicity in rat EEG model relative to adriamycin | 1978 | Journal of medicinal chemistry, Aug, Volume: 21, Issue:8
| Antitumor anthracycline antibiotics. Structure-activity and structure-cardiotoxicity relationships of rubidazone analogues. |
| AID1638229 | Selectivity ratio of IC50 for human MCF7 cells to IC50 for human MCF7/ADR cells | 2019 | European journal of medicinal chemistry, Mar-01, Volume: 165 | Discovery and synthesis of sulfur-containing 6-substituted 5,8-dimethoxy-1,4-naphthoquinone oxime derivatives as new and potential anti-MDR cancer agents. |
| AID569499 | Cytotoxicity against human OVCAR8 cells after 48 hrs by sulforhodamine B assay | 2011 | European journal of medicinal chemistry, Feb, Volume: 46, Issue:2
| Synthesis and biological evaluation of 3,5-diaryl isoxazoline/isoxazole linked 2,3-dihydroquinazolinone hybrids as anticancer agents. |
| AID478306 | Cytotoxicity against human 518A2 cells assessed as increase in ROS production at 5 uM after 72 hrs by NBT reduction assay relative to control | 2010 | European journal of medicinal chemistry, May, Volume: 45, Issue:5
| Modulation of doxorubicin activity in cancer cells by conjugation with fatty acyl and terpenyl hydrazones. |
| AID733309 | Growth inhibition of human MCF7 cells at 2 uM after 48 hrs by MTT assay | 2013 | European journal of medicinal chemistry, Apr, Volume: 62 | Synthesis, structure activity relationship and mode of action of 3-substitutedphenyl-1-(2,2,8,8-tetramethyl-3,4,9,10-tetrahydro-2H,8H-pyrano[2,3-f]chromen-6-yl)-propenones as novel anticancer agents in human leukaemia HL-60 cells. |
| AID1265154 | Growth inhibition of human HeLa cells after 72 hrs by MTT assay | 2015 | Journal of natural products, Nov-25, Volume: 78, Issue:11
| Isolation and Structure of Kurahyne B and Total Synthesis of the Kurahynes. |
| AID1902211 | Cytotoxicity against human Eca-109 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay | 2022 | European journal of medicinal chemistry, Mar-15, Volume: 232 | Semisynthesis and biological evaluation of (+)-sclerotiorin derivatives as antitumor agents for the treatment of hepatocellular carcinoma. |
| AID566779 | Cytotoxicity against human HL60 cells after 48 hrs by MTT assay | 2010 | Journal of natural products, Dec-27, Volume: 73, Issue:12
| Cytotoxic triterpenoids from Maytenus retusa. |
| AID1486982 | Cytotoxicity against human K562/A02 cells after 48 hrs by MTT assay | 2017 | Bioorganic & medicinal chemistry, 08-01, Volume: 25, Issue:15
| Synthesis and biological evaluation of JL-A7 derivatives as potent ABCB1 inhibitors. |
| AID484661 | Cytotoxicity against human Gurav cells after 48 hrs by SRB assay | 2010 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 20, Issue:11
| Synthesis, anticancer activity and apoptosis inducing ability of anthranilamide-PBD conjugates. |
| AID1754634 | Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 72 hrs by MTT assay | | | |
| AID1408894 | Cytotoxicity against mouse NIH/3T3 cells assessed as cell viability at 100 uM after 48 hrs by MTT assay relative to control | 2018 | European journal of medicinal chemistry, Oct-05, Volume: 158 | Discovery of novel human inosine 5'-monophosphate dehydrogenase 2 (hIMPDH2) inhibitors as potential anticancer agents. |
| AID1281567 | Potency index, ratio of DHEA IC50 to compound IC50 for antiproliferative activity against human T47D cells after 96 hrs by sulforhodamine B assay | 2016 | European journal of medicinal chemistry, Mar-23, Volume: 111 | Synthesis and biological evaluation of D-ring fused 1,2,3-thiadiazole dehydroepiandrosterone derivatives as antitumor agents. |
| AID1577581 | Antiproliferative activity against human HeLa cells measured after 72 hrs by EZ-Cytox assay | 2019 | Journal of medicinal chemistry, 09-12, Volume: 62, Issue:17
| Discovery and Biological Evaluations of Halogenated 2,4-Diphenyl Indeno[1,2- |
| AID1594848 | Cytotoxicity in human A549 cells assessed as inhibition of cell viability incubated for 72 hrs by CCK-8 assay | 2019 | Journal of natural products, 06-28, Volume: 82, Issue:6
| 17- nor-Cephalotane-Type Diterpenoids from Cephalotaxus fortunei. |
| AID1546806 | Cytotoxicity against human Bel7402 cells after 24 hrs by SRB method | 2020 | Journal of natural products, 01-24, Volume: 83, Issue:1
| Prenylated |
| AID1751132 | Cytotoxicity against human HepG2 cells assessed as reduction in cell viability by MTT assay | | | |
| AID1287951 | Cytotoxicity against human HCT15 cells after 3 days by CCK8 assay | 2016 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 26, Issue:7
| Effect of chlorine substituent on cytotoxic activities: Design and synthesis of systematically modified 2,4-diphenyl-5H-indeno[1,2-b]pyridines. |
| AID1637348 | Cytotoxicity against human HeLa cells assessed as cell viability at 10 uM after 2 days by MTT assay relative to control | 2016 | Bioorganic & medicinal chemistry, 10-01, Volume: 24, Issue:19
| In vitro cytotoxicity of novel 2,5,7-tricarbo-substituted indoles derived from 2-amino-5-bromo-3-iodoacetophenone. |
| AID1165134 | Induction of DNA intercalation in Escherichia coli pBR322 DNA at 100 uM by DNA gel electrophoresis | 2014 | European journal of medicinal chemistry, Oct-30, Volume: 86 | Design and synthesis of 2-phenylnaphthalenoids as inhibitors of DNA topoisomeraseIIα and antitumor agents. |
| AID1675629 | Cytotoxicity against human U87 cells assessed as reduction in cell viability by SRB assay | 2020 | Journal of natural products, 09-25, Volume: 83, Issue:9
| Monacycliones G-K and |
| AID1776432 | Cytotoxicity against human NCI-H12199 cells assessed as cell viability inhibition for 48 hrs by MTT assay | 2021 | Journal of natural products, 05-28, Volume: 84, Issue:5
| Diverse Prenylated Bibenzyl Enantiomers from the Chinese Liverwort |
| AID249858 | Percent control of human mammary adenocarcinoma MCF-7 cell line proliferation at 300 ng/mL | 2004 | Bioorganic & medicinal chemistry letters, Sep-20, Volume: 14, Issue:18
| Formation of squaric acid amides of anthracycline antibiotics. Synthesis and cytotoxic properties. |
| AID1172772 | Anti-proliferative activity against human MDA-MB-231 cells by XTT assay | 2014 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 24, Issue:22
| Synthesis and SAR studies of bis-chromenone derivatives for anti-proliferative activity against human cancer cells. |
| AID1906033 | Antiproliferative activity against human MCF7/ADR cells after 48 hrs by MTT assay | 2022 | European journal of medicinal chemistry, May-05, Volume: 235 | Development of oxoisoaporphine derivatives with topoisomerase I inhibition and reversal of multidrug resistance in breast cancer MCF-7/ADR cells. |
| AID1612626 | Antiproliferative activity against human ADR-resistant Bel7402/ADR cells after 72 hrs by MTT assay | 2019 | European journal of medicinal chemistry, Feb-01, Volume: 163 | Design, synthesis and biological evaluation of quinoline-indole derivatives as anti-tubulin agents targeting the colchicine binding site. |
| AID1671757 | Inhibition of epithelial-mesenchymal transition in human SMMC-7721 cells assessed as decrease in TGF-beta1-induced MMP9 expression at 0.5 uM incubated for 48 hrs by Western blot analysis | 2019 | European journal of medicinal chemistry, Mar-15, Volume: 166 | Excellent antitumor and antimetastatic activities based on novel coumarin/pyrazole oxime hybrids. |
| AID633822 | Cytotoxicity against human HBL100 cells after 24 hrs by MTT assay | 2012 | Bioorganic & medicinal chemistry, Jan-01, Volume: 20, Issue:1
| Synthesis, antiproliferative activity and genotoxicity of novel anthracene-containing aminophosphonates and a new anthracene-derived Schiff base. |
| AID1867129 | Cytotoxicity against human ASPC1 cells assessed as inhibition of cell growth incubated for 72 hrs by SRB assay | 2022 | Journal of natural products, 04-22, Volume: 85, Issue:4
| Cytotoxic Nitrobenzoyl Sesquiterpenoids from an Antarctica Sponge-Derived |
| AID1075860 | Cytotoxicity against human MCF7 cells assessed as growth inhibition by SRB assay | 2014 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 24, Issue:5
| Further constituents of Galianthe thalictroides (Rubiaceae) and inhibition of DNA topoisomerases I and IIα by its cytotoxic β-carboline alkaloids. |
| AID490202 | Cytotoxicity against human BCG823 cells by MTT assay | 2010 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 20, Issue:13
| Synthesis of novel beta-carbolines with efficient DNA-binding capacity and potent cytotoxicity. |
| AID1895013 | Anticancer activity against human HepG2 cells assessed as inhibition of cell growth by MTT assay | 2021 | European journal of medicinal chemistry, Aug-05, Volume: 220 | Discovery of cytotoxic natural products from Red Sea sponges: Structure and synthesis. |
| AID1426445 | Antiproliferative activity against human K562 cells after 48 hrs by Alamar blue dye based neubauer hemocytometer method | 2017 | Journal of medicinal chemistry, 01-26, Volume: 60, Issue:2
| N-Heterocyclic (4-Phenylpiperazin-1-yl)methanones Derived from Phenoxazine and Phenothiazine as Highly Potent Inhibitors of Tubulin Polymerization. |
| AID1337475 | Antiproliferative activity against human DU145 cells after 72 hrs by CCK8 assay | 2017 | European journal of medicinal chemistry, Jan-05, Volume: 125 | Novel 2-aryl-4-(4'-hydroxyphenyl)-5H-indeno[1,2-b]pyridines as potent DNA non-intercalative topoisomerase catalytic inhibitors. |
| AID1408893 | Cytotoxicity against mouse NIH/3T3 cells assessed as cell viability at 10 uM after 48 hrs by MTT assay relative to control | 2018 | European journal of medicinal chemistry, Oct-05, Volume: 158 | Discovery of novel human inosine 5'-monophosphate dehydrogenase 2 (hIMPDH2) inhibitors as potential anticancer agents. |
| AID1168526 | Toxicity in mouse S180 cells allografted mouse assessed as kidney weight at 1 umol/kg, ip for 7 consecutive days measured 24 hrs after last dose (Rvb = 0.16 +/- 0.04 g) | 2014 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 24, Issue:22
| Synthesis and biological evaluation of a novel class of coumarin derivatives. |
| AID619822 | Cytotoxicity against human HT-29 cells by MTT assay | 2011 | European journal of medicinal chemistry, Oct, Volume: 46, Issue:10
| Synthesis and biological evaluation of 1,9-disubstituted β-carbolines as potent DNA intercalating and cytotoxic agents. |
| AID1358350 | Selectivity index, ratio of IC50 against human PANC1 cells under normoxic condition to IC50 for human PANC1 cells under hypoxic condition | 2018 | European journal of medicinal chemistry, May-10, Volume: 151 | Syntheses and anti-pancreatic cancer activities of rakicidin A analogues. |
| AID566857 | Cytotoxicity against human MCF7 cells at 1 uM after 48 hrs by MTT assay | 2010 | Journal of natural products, Dec-27, Volume: 73, Issue:12
| Cytotoxic triterpenoids from Maytenus retusa. |
| AID1524522 | Cytotoxicity against human L02 cells measured after 48 hrs by MTT assay | | | |
| AID592695 | Cytotoxicity against human MCF7 cells after 48 hrs by sulforhodamine B based ELISA | 2011 | Bioorganic & medicinal chemistry, Apr-01, Volume: 19, Issue:7
| Synthesis of a new 4-aza-2,3-didehydropodophyllotoxin analogues as potent cytotoxic and antimitotic agents. |
| AID1594690 | Cytotoxicity in human U87 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay | 2019 | Journal of natural products, 06-28, Volume: 82, Issue:6
| Asperunguisins A-F, Cytotoxic Asperane Sesterterpenoids from the Endolichenic Fungus Aspergillus unguis. |
| AID1288094 | Cytotoxicity against human HeLa cells after 48 hrs by CCK8 assay | 2016 | European journal of medicinal chemistry, May-04, Volume: 113 | A new series of 2-phenol-4-aryl-6-chlorophenyl pyridine derivatives as dual topoisomerase I/II inhibitors: Synthesis, biological evaluation and 3D-QSAR study. |
| AID484660 | Cytotoxicity against human KB cells after 48 hrs by SRB assay | 2010 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 20, Issue:11
| Synthesis, anticancer activity and apoptosis inducing ability of anthranilamide-PBD conjugates. |
| AID1441128 | Cytotoxicity against human JIMT1 cells assessed as decrease in cell viability up to 8 uM after 48 hrs in presence of pan-caspase inhibitor QVD-OPh by MTS assay | 2017 | Journal of medicinal chemistry, 03-09, Volume: 60, Issue:5
| Replacing d-Glucosamine with Its l-Enantiomer in Glycosylated Antitumor Ether Lipids (GAELs) Retains Cytotoxic Effects against Epithelial Cancer Cells and Cancer Stem Cells. |
| AID1308436 | Induction of intracellular ROS accumulation in human U2OS/DX580 cells at 5 uM incubated for 24 hrs by DCFDA-AM probe-based fluorimetrical analysis relative to control | 2016 | Journal of medicinal chemistry, 05-26, Volume: 59, Issue:10
| H2S-Donating Doxorubicins May Overcome Cardiotoxicity and Multidrug Resistance. |
| AID1504778 | Cytotoxicity against human HL60 cells by MTT assay | 2017 | Journal of natural products, 12-22, Volume: 80, Issue:12
| Cephanolides A-J, Cephalotane-Type Diterpenoids from Cephalotaxus sinensis. |
| AID452683 | Cytotoxicity against human MDA-MB-231 cells after 3 days | 2010 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 20, Issue:1
| 2,6-Dithienyl-4-furyl pyridines: Synthesis, topoisomerase I and II inhibition, cytotoxicity, structure-activity relationship, and docking study. |
| AID484658 | Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay | 2010 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 20, Issue:11
| Synthesis, anticancer activity and apoptosis inducing ability of anthranilamide-PBD conjugates. |
| AID461180 | Antitumor activity against human CCRF-CEM cells | 2010 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 20, Issue:3
| Polar 3-alkylidene-5-pivaloyloxymethyl-5'-hydroxymethyl-gamma-lactones as protein kinase C ligands and antitumor agents. |
| AID1637332 | Induction of apoptosis in human HeLa cells assessed as early apoptotic cells at 3 uM after 48 hrs by Annexin V/propidium iodide staining based flow cytometric analysis (Rvb = 0.05 +/- 0.07 %) | 2016 | Bioorganic & medicinal chemistry, 10-01, Volume: 24, Issue:19
| In vitro cytotoxicity of novel 2,5,7-tricarbo-substituted indoles derived from 2-amino-5-bromo-3-iodoacetophenone. |
| AID1637338 | Induction of apoptosis in human HeLa cells assessed as caspase 3 activation at 0.75 to 3 uM after 24 hrs by colorimetric analysis | 2016 | Bioorganic & medicinal chemistry, 10-01, Volume: 24, Issue:19
| In vitro cytotoxicity of novel 2,5,7-tricarbo-substituted indoles derived from 2-amino-5-bromo-3-iodoacetophenone. |
| AID1355288 | Cytotoxicity against human MDA-MB-231 cells assessed as inhibition of cell proliferation measured after 72 hrs by sulforhodamine B assay | 2018 | Journal of natural products, 06-22, Volume: 81, Issue:6
| Cytotoxic Drimane Sesquiterpenoids Isolated from Perenniporia maackiae. |
| AID156025 | Cytotoxicity against PC-3 cell line in the purdue cell culture screen was determined | 1999 | Bioorganic & medicinal chemistry letters, Feb-08, Volume: 9, Issue:3
| On the relationship of OSW-1 to the cephalostatins. |
| AID1185777 | Growth inhibition of human Bcap37 cells at 10 uM after 72 hrs by MTT assay | 2014 | European journal of medicinal chemistry, Sep-12, Volume: 84 | Synthesis and biological evaluation of novel 6-chloro-quinazolin derivatives as potential antitumor agents. |
| AID1193350 | Growth inhibition of human PC3 cells by colorimetric MTT assay | 2015 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 25, Issue:7
| Nine new diterpenes from the leaves of plantation-grown Cunninghamia lanceolata. |
| AID1612619 | Antiproliferative activity against human taxol-resistant HCT8/T cells after 72 hrs by MTT assay | 2019 | European journal of medicinal chemistry, Feb-01, Volume: 163 | Design, synthesis and biological evaluation of quinoline-indole derivatives as anti-tubulin agents targeting the colchicine binding site. |
| AID382550 | Cytotoxicity against human KB cells by MTT assay | 2008 | European journal of medicinal chemistry, Feb, Volume: 43, Issue:2
| Anti-tumor 12-deoxyphorbol esters from Euphorbia cornigera. |
| AID1899074 | Antiproliferative activity against human K562/Adr cells measured after 72 hrs by SRB assay | | | |
| AID1671756 | Inhibition of epithelial-mesenchymal transition in human SMMC-7721 cells assessed as decrease in TGF-beta1-induced vimentin expression at 0.5 uM incubated for 48 hrs by Western blot analysis | 2019 | European journal of medicinal chemistry, Mar-15, Volume: 166 | Excellent antitumor and antimetastatic activities based on novel coumarin/pyrazole oxime hybrids. |
| AID1905033 | Antiproliferative activity against human A549 cells assessed as cell viability incubated for 48 hrs by MTT assay | 2022 | Journal of medicinal chemistry, 03-24, Volume: 65, Issue:6
| Discovery of a Novel Stilbene Derivative as a Microtubule Targeting Agent Capable of Inducing Cell Ferroptosis. |
| AID1615740 | Cytotoxicity against human HCT116 cells assessed as reduction in cell viability after 24 hrs by SRB assay | 2019 | Journal of natural products, 09-27, Volume: 82, Issue:9
| Pyrimidine Nucleosides from |
| AID1402304 | Induction of apoptosis in human SMMC7721 cells assessed as apoptotic cells at 3.2 uM after 72 hrs by FITC-Annexin-V/7AAD/propidium iodide staining based flow cytometry relative to control | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | Development of novel bis-pyrazole derivatives as antitumor agents with potent apoptosis induction effects and DNA damage. |
| AID1075859 | Cytotoxicity against human UACC62 cells assessed as growth inhibition by SRB assay | 2014 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 24, Issue:5
| Further constituents of Galianthe thalictroides (Rubiaceae) and inhibition of DNA topoisomerases I and IIα by its cytotoxic β-carboline alkaloids. |
| AID1637406 | Antiproliferative activity against human K562 cells after 72 hrs by CCK8 assay | 2016 | Bioorganic & medicinal chemistry letters, 09-15, Volume: 26, Issue:18
| Design, synthesis and evaluation of the multidrug resistance-reversing activity of pyridine acid esters of podophyllotoxin in human leukemia cells. |
| AID1671764 | Inhibition of epithelial-mesenchymal transition in human SMMC-7721 cells assessed as decrease in TGF-beta1-induced MMP9 expression at 0.5 uM incubated for 48 hrs by immunofluorescence staining based laser-scanning confocal microscope | 2019 | European journal of medicinal chemistry, Mar-15, Volume: 166 | Excellent antitumor and antimetastatic activities based on novel coumarin/pyrazole oxime hybrids. |
| AID335971 | Cytotoxicity against human HCT8 cells | | | |
| AID1370456 | Cytotoxicity against human HepG2 cells assessed as cell viability up to 70 uM after 2 hrs by MTS assay | 2018 | Bioorganic & medicinal chemistry letters, 02-01, Volume: 28, Issue:3
| Synthesis and biological evaluation of novel doxorubicin-containing ASGP-R-targeted drug-conjugates. |
| AID1423925 | Cytotoxicity against human BGC823 cells assessed as inhibition of growth incubated for 72 hrs by MTT assay | 2017 | Journal of natural products, 04-28, Volume: 80, Issue:4
| Cytotoxic Fusicoccane-Type Diterpenoids from Streptomyces violascens Isolated from Ailuropoda melanoleuca Feces. |
| AID478304 | Induction of apoptosis in human HL60 cells assessed as appearance of intact mitochondria in cytosol at 5 uM after 18 hrs using JC1 dye relative to control | 2010 | European journal of medicinal chemistry, May, Volume: 45, Issue:5
| Modulation of doxorubicin activity in cancer cells by conjugation with fatty acyl and terpenyl hydrazones. |
| AID1126887 | Cytotoxicity against human MV4-11 cells assessed as cell viability after 72 hrs by MTT assay | 2014 | European journal of medicinal chemistry, May-06, Volume: 78 | Synthesis and in vitro cytotoxic effect of 6-amino-substituted 11H- and 11Me-indolo[3,2-c]quinolines. |
| AID478299 | Induction of apoptosis in human 518A2 cells assessed as increase of Bcl-2 mRNA expression at 5 uM up to 24 hrs by Western blot analysis | 2010 | European journal of medicinal chemistry, May, Volume: 45, Issue:5
| Modulation of doxorubicin activity in cancer cells by conjugation with fatty acyl and terpenyl hydrazones. |
| AID1768120 | Cytotoxicity against human HCT-116 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay | 2021 | Journal of natural products, 07-23, Volume: 84, Issue:7
| Iridoid Constituents of |
| AID1543249 | Cytotoxicity in human HT-29 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay | 2019 | Journal of natural products, 07-26, Volume: 82, Issue:7
| Prenylated Bibenzyls from the Chinese Liverwort |
| AID1320985 | Cytotoxicity against human HCC1428 cells assessed as decrease in cell viability after 48 hrs by MTT assay | 2016 | European journal of medicinal chemistry, Oct-04, Volume: 121 | Design, synthesis and biological evaluation of novel macrocyclic bisbibenzyl analogues as tubulin polymerization inhibitors. |
| AID1358351 | Cytotoxicity against human Aspc-1 cells after 72 hrs under normoxic condition by MTT assay | 2018 | European journal of medicinal chemistry, May-10, Volume: 151 | Syntheses and anti-pancreatic cancer activities of rakicidin A analogues. |
| AID1163589 | Resistance index, ratio of IC50 for adriamycin resistant human MCF7 cells to IC50 for parental human MCF7 cells | 2014 | Journal of medicinal chemistry, Oct-09, Volume: 57, Issue:19
| Synthesis and biological evaluation of novel millepachine derivatives as a new class of tubulin polymerization inhibitors. |
| AID1907345 | Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay | 2022 | European journal of medicinal chemistry, Jun-05, Volume: 236 | Synthesis and structure-activity relationship study of a potent MHO7 analogue as potential anti-triple negative breast cancer agent. |
| AID1637349 | Cytotoxicity against human HeLa cells assessed as cell viability at 5 uM after 2 days by MTT assay relative to control | 2016 | Bioorganic & medicinal chemistry, 10-01, Volume: 24, Issue:19
| In vitro cytotoxicity of novel 2,5,7-tricarbo-substituted indoles derived from 2-amino-5-bromo-3-iodoacetophenone. |
| AID1882810 | Anticancer activity against human SNU1 cells assessed as reduction in cell viability for 72 hrs by MTT assay | 2022 | European journal of medicinal chemistry, May-05, Volume: 235 | Recent advances of antitumor shikonin/alkannin derivatives: A comprehensive overview focusing on structural classification, synthetic approaches, and mechanisms of action. |
| AID1421550 | Antiproliferative activity against human HCT116 cells assessed as inhibition of cell growth at 1 uM after 72 hrs by sulforhodamine B assay relative to control | 2018 | European journal of medicinal chemistry, Oct-05, Volume: 158 | Four new antitumor metabolites isolated from a mutant 3-f-31 strain derived from Penicillium purpurogenum G59. |
| AID689428 | Cytotoxicity against human MCF7 cells after 72 hrs by SRB assay | 2012 | Journal of medicinal chemistry, Jun-14, Volume: 55, Issue:11
| Synthesis and biological evaluation of new amino acid and dipeptide derivatives of neocryptolepine as anticancer agents. |
| AID467997 | Cytotoxicity activity against mouse LLC cells after 48 hrs by MTT assay | 2009 | Journal of natural products, Aug, Volume: 72, Issue:8
| Oleanane-type triterpenoids from Aceriphyllum rossii and their cytotoxic activity. |
| AID1264618 | Cytotoxicity against human HCT116 cells after 72 hrs by MTT assay | 2015 | Journal of natural products, Nov-25, Volume: 78, Issue:11
| Versixanthones A-F, Cytotoxic Xanthone-Chromanone Dimers from the Marine-Derived Fungus Aspergillus versicolor HDN1009. |
| AID1907350 | Selectivity index, ratio of IC50 for Cytotoxic activity against human MCF-10A cells to IC50 for antiproliferative activity against human NCI-ADR-RES cells | 2022 | European journal of medicinal chemistry, Jun-05, Volume: 236 | Synthesis and structure-activity relationship study of a potent MHO7 analogue as potential anti-triple negative breast cancer agent. |
| AID1508155 | Cell cycle arrest in human MCF7 cells assessed as accumulation at G2/M phase at 2 uM after 24 hrs by flow cytometric analysis (Rvb = 2.35%) | 2017 | European journal of medicinal chemistry, Oct-20, Volume: 139 | Design, synthesis and biological evaluation of novel pyrazolochalcones as potential modulators of PI3K/Akt/mTOR pathway and inducers of apoptosis in breast cancer cells. |
| AID1308415 | Drug uptake in human U2OS/DX30 cells at 5 uM incubated for 24 hrs by fluorimetrical analysis | 2016 | Journal of medicinal chemistry, 05-26, Volume: 59, Issue:10
| H2S-Donating Doxorubicins May Overcome Cardiotoxicity and Multidrug Resistance. |
| AID1321046 | Cytotoxicity against human HT1080 cells assessed as reduction cell viability after 72 hrs by WST8-based colorimetric analysis | 2016 | Journal of natural products, 07-22, Volume: 79, Issue:7
| Isolation and Structure Elucidation of Cytotoxic Saccharothriolides D to F from a Rare Actinomycete Saccharothrix sp. and Their Structure-Activity Relationship. |
| AID1436221 | Cytotoxicity against human HeLa cells assessed as cell growth at 10'-6 M after 48 hrs by SRB assay relative to control | 2017 | European journal of medicinal chemistry, Jan-27, Volume: 126 | Piperlongumine derived cyclic sulfonamides (sultams): Synthesis and in vitro exploration for therapeutic potential against HeLa cancer cell lines. |
| AID592927 | Cytotoxicity against human A549 cells by sulforhodamine B method | 2011 | Bioorganic & medicinal chemistry, Apr-15, Volume: 19, Issue:8
| Synthesis and biological evaluation of estradiol linked pyrrolo[2,1-c][1,4]benzodiazepine (PBD) conjugates as potential anticancer agents. |
| AID334275 | Antiproliferative activity against mouse B16-BL6 cells after 72 hrs by MTT assay | 2002 | Journal of natural products, May, Volume: 65, Issue:5
| Constituents of Chinese propolis and their antiproliferative activities. |
| AID619899 | Cytotoxicity against human MCF7 cells by MTT assay | 2011 | European journal of medicinal chemistry, Oct, Volume: 46, Issue:10
| Synthesis and biological evaluation of 1,9-disubstituted β-carbolines as potent DNA intercalating and cytotoxic agents. |
| AID1288620 | Cytotoxicity against human K562 cells assessed as cell viability after 48 hrs by MTT assay | 2016 | Bioorganic & medicinal chemistry, 05-15, Volume: 24, Issue:10
| Design, synthesis and biological evaluation of LBM-A5 derivatives as potent P-glycoprotein-mediated multidrug resistance inhibitors. |
| AID621712 | Antiproliferative activity against human A549 cells by MTT assay | 2011 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 21, Issue:19
| Constructing transferrin receptor targeted drug delivery system by using doxorubicin hydrochloride and vanadocene dichloride. |
| AID1633071 | Cytotoxicity against human HepG2 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay | 2017 | Bioorganic & medicinal chemistry, 10-15, Volume: 25, Issue:20
| A novel delocalized lipophilic cation-chlorambucil conjugate inhibits P-glycoprotein in HepG2/ADM cells. |
| AID592422 | Cytotoxicity against human HL60 cells assessed as inhibition of cell proliferation after 72 hrs by MTT assay | 2011 | Journal of natural products, Mar-25, Volume: 74, Issue:3
| Trigonosins A-F, daphnane diterpenoids from Trigonostemon thyrsoideum. |
| AID1462339 | Cytotoxicity against African green monkey Vero cells assessed as total inhibition of cell growth after 72 hrs by sulforhodamine B assay | | | |
| AID1594721 | Cytotoxicity against human HL60 cells measured after 72 hrs by CCK8 assay | 2019 | Journal of natural products, 06-28, Volume: 82, Issue:6
| Cytotoxic Tigliane Diterpenoids from Croton damayeshu. |
| AID734087 | Growth inhibition against human IGROV-ET cells after 72 hrs by inverted microscopy | 2013 | European journal of medicinal chemistry, Apr, Volume: 62 | Synthesis, cytotoxicity and antiplasmodial activity of novel ent-kaurane derivatives. |
| AID1308410 | Drug uptake in rat H9c2 cells at 5 uM incubated for 24 hrs by fluorimetrical analysis | 2016 | Journal of medicinal chemistry, 05-26, Volume: 59, Issue:10
| H2S-Donating Doxorubicins May Overcome Cardiotoxicity and Multidrug Resistance. |
| AID509753 | Cytotoxicity against human KB/VCR cells expressing Pgp after 48 hrs by MTT assay | 2010 | Bioorganic & medicinal chemistry, Sep-15, Volume: 18, Issue:18
| Bisbibenzyl derivatives sensitize vincristine-resistant KB/VCR cells to chemotherapeutic agents by retarding P-gp activity. |
| AID592696 | Cytotoxicity against human KB cells after 48 hrs by sulforhodamine B based ELISA | 2011 | Bioorganic & medicinal chemistry, Apr-01, Volume: 19, Issue:7
| Synthesis of a new 4-aza-2,3-didehydropodophyllotoxin analogues as potent cytotoxic and antimitotic agents. |
| AID1132917 | In vivo antitumor activity against mouse P388 cells allografted in BDF/CDF mouse assessed as host survival time at 0.5 mg/kg, ip administered on days 1 to 9 relative to control | 1978 | Journal of medicinal chemistry, Aug, Volume: 21, Issue:8
| Antitumor anthracycline antibiotics. Structure-activity and structure-cardiotoxicity relationships of rubidazone analogues. |
| AID509772 | Reversal of P-gp-mediated multidrug-resistance in human KB/VCR cells assessed as increase in intracellular adriamycin accumulation at 16 uM after 1 hr by flow cytometry relative to control | 2010 | Bioorganic & medicinal chemistry, Sep-15, Volume: 18, Issue:18
| Bisbibenzyl derivatives sensitize vincristine-resistant KB/VCR cells to chemotherapeutic agents by retarding P-gp activity. |
| AID1426673 | Antitumor activity against P-gp overexpressing/drug resistant human K562/A02 cells xenografted in BALB/c nude mouse assessed as tumor growth inhibition at 4 mg/kg, iv administered every other day for 21 days measured post last dose relative to control | 2017 | Journal of medicinal chemistry, 02-09, Volume: 60, Issue:3
| Potent Inhibition of Nitric Oxide-Releasing Bifendate Derivatives against Drug-Resistant K562/A02 Cells in Vitro and in Vivo. |
| AID303684 | Antiproliferative activity against human K562 cells after 48 hrs | 2007 | Journal of medicinal chemistry, Nov-29, Volume: 50, Issue:24
| Sulfonate derivatives of naphtho[2,3-b]thiophen-4(9H)-one and 9(10H)-anthracenone as highly active antimicrotubule agents. Synthesis, antiproliferative activity, and inhibition of tubulin polymerization. |
| AID484663 | Cytotoxicity against human A2780 cells after 48 hrs by SRB assay | 2010 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 20, Issue:11
| Synthesis, anticancer activity and apoptosis inducing ability of anthranilamide-PBD conjugates. |
| AID1185776 | Growth inhibition of human MGC803 cells at 10 uM after 72 hrs by MTT assay | 2014 | European journal of medicinal chemistry, Sep-12, Volume: 84 | Synthesis and biological evaluation of novel 6-chloro-quinazolin derivatives as potential antitumor agents. |
| AID1500606 | Antiproliferative activity against human MCF7/ADR cells after 48 hrs by MTT assay | 2017 | European journal of medicinal chemistry, Sep-29, Volume: 138 | Design, synthesis and biological evaluation of 4-anilinoquinoline derivatives as novel potent tubulin depolymerization agents. |
| AID1675633 | Cytotoxicity against human HL-60 cells assessed as reduction in cell viability by MTT assay | 2020 | Journal of natural products, 09-25, Volume: 83, Issue:9
| Monacycliones G-K and |
| AID103239 | Cytotoxicity against MCF-7ADR cell line in the purdue cell culture screen was determined | 1999 | Bioorganic & medicinal chemistry letters, Feb-08, Volume: 9, Issue:3
| On the relationship of OSW-1 to the cephalostatins. |
| AID1637405 | Antiproliferative activity against human K562/ADR cells after 72 hrs by CCK8 assay | 2016 | Bioorganic & medicinal chemistry letters, 09-15, Volume: 26, Issue:18
| Design, synthesis and evaluation of the multidrug resistance-reversing activity of pyridine acid esters of podophyllotoxin in human leukemia cells. |
| AID452929 | Cytotoxicity against human HL60 cells by MTT assay | 2010 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 20, Issue:1
| Two novel neo-clerodane diterpenoids from Scutellaria barbata. |
| AID1815019 | Cytotoxicity against human MDA-MB-231 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay | 2021 | Journal of natural products, 08-27, Volume: 84, Issue:8
| Cryptoyunnanones A-H, Complex Flavanones from |
| AID1185516 | Cytotoxicity against human HCT15 cells after 4 days by CCK-8 assay | 2014 | European journal of medicinal chemistry, Sep-12, Volume: 84 | Synthesis, antitumor activity, and structure-activity relationship study of trihydroxylated 2,4,6-triphenyl pyridines as potent and selective topoisomerase II inhibitors. |
| AID490286 | Antiproliferative activity against mouse SFME cells after 24 hrs by MTT assay | 2010 | European journal of medicinal chemistry, Jul, Volume: 45, Issue:7
| Novel effects of glycyrrhetinic acid on the central nervous system tumorigenic progenitor cells: induction of actin disruption and tumor cell-selective toxicity. |
| AID1751128 | Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability by MTT assay | | | |
| AID1498581 | Resistance factor, ratio of IC50 for human MDA-MB-231/ADR cells to IC50 for human MDA-MB-231 cells | 2018 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 28, Issue:14
| The inhibitory effect of kokusaginine on the growth of human breast cancer cells and MDR-resistant cells is mediated by the inhibition of tubulin assembly. |
| AID1500610 | Resistance index, ratio of IC50 for human MCF7/ADR cells to IC50 for human MCF7 cells | 2017 | European journal of medicinal chemistry, Sep-29, Volume: 138 | Design, synthesis and biological evaluation of 4-anilinoquinoline derivatives as novel potent tubulin depolymerization agents. |
| AID1541626 | Cytotoxicity against human MCF7 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay | 2019 | Journal of natural products, 12-27, Volume: 82, Issue:12
| Glucoconjugated Monoterpene Indole Alkaloids from |
| AID1400965 | Antiproliferative activity in human K562 cells after 48 hrs by MTT assay | 2017 | European journal of medicinal chemistry, Aug-18, Volume: 136 | Design, synthesis and biological evaluation of nitrogen-containing macrocyclic bisbibenzyl derivatives as potent anticancer agents by targeting the lysosome. |
| AID1277892 | Cytotoxicity against human HepG2 cells assessed as cell viability after 48 hrs by MTT assay | 2016 | Bioorganic & medicinal chemistry letters, Feb-15, Volume: 26, Issue:4
| Structure activity relationship, cytotoxicity and evaluation of antioxidant activity of curcumin derivatives. |
| AID1075861 | Cytotoxicity against human 786-0 cells assessed as growth inhibition by SRB assay | 2014 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 24, Issue:5
| Further constituents of Galianthe thalictroides (Rubiaceae) and inhibition of DNA topoisomerases I and IIα by its cytotoxic β-carboline alkaloids. |
| AID1421554 | Antiproliferative activity against human K562 cells assessed as inhibition of cell growth at 1 uM after 72 hrs by MTT assay relative to control | 2018 | European journal of medicinal chemistry, Oct-05, Volume: 158 | Four new antitumor metabolites isolated from a mutant 3-f-31 strain derived from Penicillium purpurogenum G59. |
| AID357611 | Antiproliferative activity against mouse Colon 26-L5 cells assessed as cell viability after 72 hrs by MTT assay | 2001 | Journal of natural products, Sep, Volume: 64, Issue:9
| New spirostanol steroids and steroidal saponins from roots and rhizomes of Dracaena angustifolia and their antiproliferative activity. |
| AID1882747 | Anticancer activity against human SMMC-7721 cells assessed as inhibition of cell proliferation incubated for 48 hrs by MTT assay | 2022 | European journal of medicinal chemistry, May-05, Volume: 235 | Recent advances of antitumor shikonin/alkannin derivatives: A comprehensive overview focusing on structural classification, synthetic approaches, and mechanisms of action. |
| AID1754635 | Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 72 hrs by MTT assay | | | |
| AID1355290 | Cytotoxicity against human NUGC3 cells assessed as inhibition of cell proliferation measured after 72 hrs by sulforhodamine B assay | 2018 | Journal of natural products, 06-22, Volume: 81, Issue:6
| Cytotoxic Drimane Sesquiterpenoids Isolated from Perenniporia maackiae. |
| AID1401810 | Cytotoxicity against human DU145 cells after 72 hrs by cell counting kit-8 analysis | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | Design, synthesis, and biological evaluation of 1,3-diarylisoquinolines as novel topoisomerase I catalytic inhibitors. |
| AID512159 | Cytotoxicity against human ZR-75-1 cells after 48 hrs by SRB assay | 2010 | European journal of medicinal chemistry, Sep, Volume: 45, Issue:9
| Synthesis and biological evaluation of cinnamido linked pyrrolo[2,1-c][1,4]benzodiazepines as antimitotic agents. |
| AID478302 | Induction of apoptosis in human 518A2 cells assessed as appearance of intact mitochondria in cytosol at 5 uM after 18 hrs using JC1 dye relative to control | 2010 | European journal of medicinal chemistry, May, Volume: 45, Issue:5
| Modulation of doxorubicin activity in cancer cells by conjugation with fatty acyl and terpenyl hydrazones. |
| AID566853 | Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay | 2010 | Journal of natural products, Dec-27, Volume: 73, Issue:12
| Cytotoxic triterpenoids from Maytenus retusa. |
| AID1185754 | Cytotoxicity against human K562 cells after 48 hrs by Alamar blue assay | 2014 | European journal of medicinal chemistry, 09-12, Volume: 84 | Synthesis and evaluation of the cytotoxic activity of 1,2-furanonaphthoquinones tethered to 1,2,3-1H-triazoles in myeloid and lymphoid leukemia cell lines. |
| AID566859 | Cytotoxicity against human MCF7 cells at 30 uM after 48 hrs by MTT assay | 2010 | Journal of natural products, Dec-27, Volume: 73, Issue:12
| Cytotoxic triterpenoids from Maytenus retusa. |
| AID1751131 | Cytotoxicity against human HeLa cells assessed as reduction in cell viability by MTT assay | | | |
| AID512241 | Anticancer activity against human SiHa cells after 48 hrs by SRB assay | 2010 | European journal of medicinal chemistry, Sep, Volume: 45, Issue:9
| Design, synthesis and biological evaluation of 3,5-diaryl-isoxazoline/isoxazole-pyrrolobenzodiazepine conjugates as potential anticancer agents. |
| AID618835 | Cytotoxicity against human K562/A02 cells after 2 days by MTT assay | 2011 | European journal of medicinal chemistry, Sep, Volume: 46, Issue:9
| Synthesis of 4β-triazole-podophyllotoxin derivatives by azide-alkyne cycloaddition and biological evaluation as potential antitumor agents. |
| AID1785518 | Antiproliferative activity against human MCF-7/ADR cells incubated for 72 hrs by MTT assay | | | |
| AID512163 | Cytotoxicity against human GURAV cells after 48 hrs by SRB assay | 2010 | European journal of medicinal chemistry, Sep, Volume: 45, Issue:9
| Synthesis and biological evaluation of cinnamido linked pyrrolo[2,1-c][1,4]benzodiazepines as antimitotic agents. |
| AID478301 | Induction of apoptosis in human 518A2 cells assessed as appearance of intact mitochondria in cytosol at 5 uM after 6 hrs using JC1 dye relative to control | 2010 | European journal of medicinal chemistry, May, Volume: 45, Issue:5
| Modulation of doxorubicin activity in cancer cells by conjugation with fatty acyl and terpenyl hydrazones. |
| AID1871299 | Cytotoxicity against human HL-60 cells assessed as cell growth inhibition | 2021 | European journal of medicinal chemistry, Jan-15, Volume: 210 | Renieramycin-type alkaloids from marine-derived organisms: Synthetic chemistry, biological activity and structural modification. |
| AID1684109 | Cytotoxicity against human HT-29 cells assessed as reduction in cell viability after 72 hrs by MTT assay | | | |
| AID1278417 | Cytotoxicity against human HL60/ADR cells after 72 hrs by MTT assay | 2016 | Bioorganic & medicinal chemistry letters, Feb-15, Volume: 26, Issue:4
| Dispirocyclopropyldehydrocostus lactone selectively inhibits acute myelogenous leukemia cells. |
| AID1428693 | Antiproliferative activity against human T47D cells after 72 hrs by CCK8 assay | 2017 | European journal of medicinal chemistry, Feb-15, Volume: 127 | Rational design, synthesis, and evaluation of novel 2,4-Chloro- and Hydroxy-Substituted diphenyl Benzofuro[3,2-b]Pyridines: Non-intercalative catalytic topoisomerase I and II dual inhibitor. |
| AID1594849 | Cytotoxicity in human HL60 cells assessed as inhibition of cell viability incubated for 72 hrs by CCK-8 assay | 2019 | Journal of natural products, 06-28, Volume: 82, Issue:6
| 17- nor-Cephalotane-Type Diterpenoids from Cephalotaxus fortunei. |
| AID478274 | Induction of apoptosis in human HL60 cells assessed as increase of caspase 9 activity at 5 uM after 12 hrs by luminometric assay | 2010 | European journal of medicinal chemistry, May, Volume: 45, Issue:5
| Modulation of doxorubicin activity in cancer cells by conjugation with fatty acyl and terpenyl hydrazones. |
| AID1902209 | Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay | 2022 | European journal of medicinal chemistry, Mar-15, Volume: 232 | Semisynthesis and biological evaluation of (+)-sclerotiorin derivatives as antitumor agents for the treatment of hepatocellular carcinoma. |
| AID333314 | Cytotoxicity against human LoVo cells after 72 hrs by MTT assay | 2004 | Journal of natural products, Sep, Volume: 67, Issue:9
| Cytotoxic constituents of roots of Chaerophyllum hirsutum. |
| AID1617195 | Cytotoxicity against human PC3 cells assessed as cell growth inhibition measured after 48 hrs by SRB assay | 2019 | Journal of natural products, 11-22, Volume: 82, Issue:11
| Resorcinosides A and B, Glycosylated Alkylresorcinols from a Marine-Derived Strain of the Fungus |
| AID1168523 | Toxicity in mouse S180 cells allografted mouse assessed as brain weight at 1 umol/kg, ip for 7 consecutive days measured 24 hrs after last dose (Rvb = 0.30 +/- 0.02 g) | 2014 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 24, Issue:22
| Synthesis and biological evaluation of a novel class of coumarin derivatives. |
| AID398902 | Cytotoxicity against human HCT8 cells | 1997 | Journal of natural products, Jun, Volume: 60, Issue:6
| Cytotoxic and antiplatelet aggregation principles from Aglaia elliptifolia. |
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| AID551370 | Cytotoxicity against human MDA-MB-231 cells after 48 hrs by MTT assay | 2011 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 21, Issue:1
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| AID378841 | Cytotoxicity against human WI38 cells | 2006 | Journal of natural products, Oct, Volume: 69, Issue:10
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| AID460540 | Cytotoxicity against human DU145 cells after 48 hrs by MTT assay | 2010 | Bioorganic & medicinal chemistry, Feb, Volume: 18, Issue:3
| New benzoxanthone derivatives as topoisomerase inhibitors and DNA cross-linkers. |
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| AID1887102 | Cytotoxicity against human H69AR cells assessed as reduction in cell viability by SRB assay | | | |
| AID1405495 | Cytotoxicity against mouse 3T3 cells | 2018 | European journal of medicinal chemistry, Aug-05, Volume: 156 | Copper(I) oxide nanoparticles catalyzed click chemistry based synthesis of melampomagnolide B-triazole conjugates and their anti-cancer activities. |
| AID404064 | Cytotoxicity against mouse 26-L5 cells after 24 hrs by MTT assay | 1998 | Journal of natural products, Jul, Volume: 61, Issue:7
| Chemical constituents of Brazilian propolis and their cytotoxic activities. |
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| Design, synthesis and biological evaluation of novel tetrahydroisoquinoline derivatives as P-glycoprotein-mediated multidrug resistance inhibitors. |
| AID1637339 | Cytotoxicity against human MCF7 cells assessed as cell viability at 2 uM after 2 days by MTT assay relative to control | 2016 | Bioorganic & medicinal chemistry, 10-01, Volume: 24, Issue:19
| In vitro cytotoxicity of novel 2,5,7-tricarbo-substituted indoles derived from 2-amino-5-bromo-3-iodoacetophenone. |
| AID1696722 | Cytotoxicity against human HL-60 cells assessed as reduction in cell viability after 48 hrs by MTT assay | 2020 | Journal of natural products, 09-25, Volume: 83, Issue:9
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| AID1264617 | Cytotoxicity against human HO8910 cells after 72 hrs by MTT assay | 2015 | Journal of natural products, Nov-25, Volume: 78, Issue:11
| Versixanthones A-F, Cytotoxic Xanthone-Chromanone Dimers from the Marine-Derived Fungus Aspergillus versicolor HDN1009. |
| AID452680 | Cytotoxicity against human DU145 cells after 3 days | 2010 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 20, Issue:1
| 2,6-Dithienyl-4-furyl pyridines: Synthesis, topoisomerase I and II inhibition, cytotoxicity, structure-activity relationship, and docking study. |
| AID1402295 | Antiproliferative activity against human SGC7901 cells after 72 hrs by MTT assay | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | Development of novel bis-pyrazole derivatives as antitumor agents with potent apoptosis induction effects and DNA damage. |
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| Discovery of a Novel Stilbene Derivative as a Microtubule Targeting Agent Capable of Inducing Cell Ferroptosis. |
| AID551375 | Cytotoxicity against human HT1080 assessed as inhibition of cell growth | 2011 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 21, Issue:1
| An efficient one-pot synthesis of benzothiazolo-4β-anilino-podophyllotoxin congeners: DNA topoisomerase-II inhibition and anticancer activity. |
| AID1633072 | Cytotoxicity against human HepG2/ADM cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay | 2017 | Bioorganic & medicinal chemistry, 10-15, Volume: 25, Issue:20
| A novel delocalized lipophilic cation-chlorambucil conjugate inhibits P-glycoprotein in HepG2/ADM cells. |
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| AID1428412 | Cytotoxicity against human MDA-MB-231 cells assessed as growth inhibition after 72 hrs by SRB assay | | | |
| AID1489125 | Cytotoxicity against human HCT8 cells assessed as reduction in cell viability after 24 hrs by CCK-8 assay | 2017 | Bioorganic & medicinal chemistry letters, 09-01, Volume: 27, Issue:17
| Discovery of novel 4(1H)-quinolone derivatives as potential antiproliferative and apoptosis inducing agents. |
| AID1675632 | Cytotoxicity against human K562 cells assessed as reduction in cell viability by MTT assay | 2020 | Journal of natural products, 09-25, Volume: 83, Issue:9
| Monacycliones G-K and |
| AID1905060 | Resistance index, ratio of IC50 for antiproliferative activity against human paclitaxel-resistant A2780/TAX cells to IC50 for antiproliferative activity against human A2780 cells | 2022 | Journal of medicinal chemistry, 03-24, Volume: 65, Issue:6
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| AID1525111 | Cytotoxicity against human PLC/PRF/5 cells assessed as reduction in cell viability by MTT assay | 2019 | Journal of natural products, 05-24, Volume: 82, Issue:5
| Strepantibins A-C: Hexokinase II Inhibitors from a Mud Dauber Wasp Associated Streptomyces sp. |
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| Discovery of novel 4(1H)-quinolone derivatives as potential antiproliferative and apoptosis inducing agents. |
| AID1421555 | Antiproliferative activity against human LS180 cells assessed as inhibition of cell growth at 1 uM after 72 hrs by sulforhodamine B assay relative to control | 2018 | European journal of medicinal chemistry, Oct-05, Volume: 158 | Four new antitumor metabolites isolated from a mutant 3-f-31 strain derived from Penicillium purpurogenum G59. |
| AID1291708 | Antitumor activity against human HepG2 cells xenografted with nude mouse assessed as tumor volume at 5 mg/kg, iv administered every 2 days for 31 days (Rvb = 103.6 +/- 1.77 mm3) | 2016 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 26, Issue:8
| Synthesis, in vitro and in vivo evaluation of novel substituted N-(4-(2-(4-benzylpiperazin-1-yl)ethoxy)phenyl)-N-methyl-quinazolin-4-amines as potent antitumor agents. |
| AID1478727 | Antiproliferative activity against human HeLa cells after 72 hrs by CCK8 assay | 2017 | European journal of medicinal chemistry, Jun-16, Volume: 133 | Dihydroxylated 2,6-diphenyl-4-chlorophenylpyridines: Topoisomerase I and IIα dual inhibitors with DNA non-intercalative catalytic activity. |
| AID599172 | Cytotoxicity against human HeLa cells after 2 days | 2011 | European journal of medicinal chemistry, Jun, Volume: 46, Issue:6
| Synthesis, biological evaluation, and molecular docking study of 3-(3'-heteroatom substituted-2'-hydroxy-1'-propyloxy) xanthone analogues as novel topoisomerase IIα catalytic inhibitor. |
| AID1308397 | Activity at PgP in human U2OS/DX500 cells assessed as Vmax measured per mg of protein incubated for 20 mins by fluorimetrical analysis | 2016 | Journal of medicinal chemistry, 05-26, Volume: 59, Issue:10
| H2S-Donating Doxorubicins May Overcome Cardiotoxicity and Multidrug Resistance. |
| AID1405492 | Antiproliferative activity against human U87 cells after 72 hrs by MTT assay | 2018 | European journal of medicinal chemistry, Aug-05, Volume: 156 | Copper(I) oxide nanoparticles catalyzed click chemistry based synthesis of melampomagnolide B-triazole conjugates and their anti-cancer activities. |
| AID1491063 | Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability after 72 hrs by MTT assay | 2017 | Journal of natural products, 05-26, Volume: 80, Issue:5
| Inflammation Modulatory Phorbol Esters from the Seeds of Aquilaria malaccensis. |
| AID1171351 | Cytotoxicity against adriamycin-resistant human MCF7 cells after 48 hrs by MTT assay | 2014 | ACS medicinal chemistry letters, Nov-13, Volume: 5, Issue:11
| Synthesis and biological evaluation of sophoridinol derivatives as a novel family of potential anticancer agents. |
| AID1498377 | Antiproliferative activity against mouse L929 cells after 72 hrs by MTT assay | 2018 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 28, Issue:14
| 2-Substituted-1-(2-morpholinoethyl)-1H-naphtho[2,3-d]imidazole-4,9-diones: Design, synthesis and antiproliferative activity. |
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| AID735845 | Cytotoxicity against human A549 cells after 72 hrs by MTT assay | 2013 | Journal of natural products, Apr-26, Volume: 76, Issue:4
| Cytotoxic polyketide derivatives from the South China Sea sponge Plakortis simplex. |
| AID633821 | Cytotoxicity against human MDA-MB-231 cells after 24 hrs by MTT assay | 2012 | Bioorganic & medicinal chemistry, Jan-01, Volume: 20, Issue:1
| Synthesis, antiproliferative activity and genotoxicity of novel anthracene-containing aminophosphonates and a new anthracene-derived Schiff base. |
| AID478256 | Cytotoxicity against human vinblastine-resistant KBV1 cells after 24 hrs by MTT assay | 2010 | European journal of medicinal chemistry, May, Volume: 45, Issue:5
| Modulation of doxorubicin activity in cancer cells by conjugation with fatty acyl and terpenyl hydrazones. |
| AID569465 | Cytotoxicity against human A549 cells after 48 hrs by sulforhodamine B assay | 2011 | European journal of medicinal chemistry, Feb, Volume: 46, Issue:2
| Synthesis and biological evaluation of 3,5-diaryl isoxazoline/isoxazole linked 2,3-dihydroquinazolinone hybrids as anticancer agents. |
| AID1675626 | Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability by SRB assay | 2020 | Journal of natural products, 09-25, Volume: 83, Issue:9
| Monacycliones G-K and |
| AID551371 | Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay | 2011 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 21, Issue:1
| Synthesis and biological evaluation of novel exo-methylene cyclopentanone tetracyclic diterpenoids as antitumor agents. |
| AID484662 | Cytotoxicity against human PC3 cells after 48 hrs by SRB assay | 2010 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 20, Issue:11
| Synthesis, anticancer activity and apoptosis inducing ability of anthranilamide-PBD conjugates. |
| AID512160 | Cytotoxicity against human A2780 cells after 48 hrs by SRB assay | 2010 | European journal of medicinal chemistry, Sep, Volume: 45, Issue:9
| Synthesis and biological evaluation of cinnamido linked pyrrolo[2,1-c][1,4]benzodiazepines as antimitotic agents. |
| AID1441126 | Cytotoxicity against human DU145 cells assessed as decrease in cell viability up to 8 uM after 48 hrs in absence of pan-caspase inhibitor QVD-OPh by MTS assay | 2017 | Journal of medicinal chemistry, 03-09, Volume: 60, Issue:5
| Replacing d-Glucosamine with Its l-Enantiomer in Glycosylated Antitumor Ether Lipids (GAELs) Retains Cytotoxic Effects against Epithelial Cancer Cells and Cancer Stem Cells. |
| AID1421549 | Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth at 1 uM after 72 hrs by sulforhodamine B assay relative to control | 2018 | European journal of medicinal chemistry, Oct-05, Volume: 158 | Four new antitumor metabolites isolated from a mutant 3-f-31 strain derived from Penicillium purpurogenum G59. |
| AID1358364 | Increase in tumor initiating cell frequency in human PANC1 cells xenografted in BALB/c nude mouse at 0.5 uM measured after 7 days | 2018 | European journal of medicinal chemistry, May-10, Volume: 151 | Syntheses and anti-pancreatic cancer activities of rakicidin A analogues. |
| AID1638228 | Selectivity ratio of IC50 for human Bel7042 cells to IC50 for human Bel7402/5-FU cells | 2019 | European journal of medicinal chemistry, Mar-01, Volume: 165 | Discovery and synthesis of sulfur-containing 6-substituted 5,8-dimethoxy-1,4-naphthoquinone oxime derivatives as new and potential anti-MDR cancer agents. |
| AID1577578 | Antiproliferative activity against human HCT15 cells measured after 72 hrs by EZ-Cytox assay | 2019 | Journal of medicinal chemistry, 09-12, Volume: 62, Issue:17
| Discovery and Biological Evaluations of Halogenated 2,4-Diphenyl Indeno[1,2- |
| AID467762 | Cytotoxicity against human HL60 cells by MTT assay | 2009 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 19, Issue:23
| Oxiranylmethyloxy or thiiranylmethyloxy-azaxanthones and -acridone analogues as potential topoisomerase I inhibitors. |
| AID1637324 | Induction of apoptosis in human HeLa cells assessed as late apoptotic cells at 3 uM after 48 hrs by Annexin V/propidium iodide staining based flow cytometric analysis (Rvb = 31.80 +/- 0.25 %) | 2016 | Bioorganic & medicinal chemistry, 10-01, Volume: 24, Issue:19
| In vitro cytotoxicity of novel 2,5,7-tricarbo-substituted indoles derived from 2-amino-5-bromo-3-iodoacetophenone. |
| AID592930 | Cytotoxicity against human KB cells by sulforhodamine B method | 2011 | Bioorganic & medicinal chemistry, Apr-15, Volume: 19, Issue:8
| Synthesis and biological evaluation of estradiol linked pyrrolo[2,1-c][1,4]benzodiazepine (PBD) conjugates as potential anticancer agents. |
| AID1185781 | Growth inhibition of human PC3 cells after 72 hrs by MTT assay | 2014 | European journal of medicinal chemistry, Sep-12, Volume: 84 | Synthesis and biological evaluation of novel 6-chloro-quinazolin derivatives as potential antitumor agents. |
| AID1164701 | Cytotoxicity against human DU145 cells after 24 hrs by MTT assay | 2014 | Journal of natural products, Sep-26, Volume: 77, Issue:9
| Notolutesins A-J, dolabrane-type diterpenoids from the Chinese liverwort Notoscyphus lutescens. |
| AID1899069 | Antiproliferative activity against human KB/VCR cells measured after 72 hrs by SRB assay | | | |
| AID1697197 | Cytotoxicity against human SW620 cells by colorimetric method | 2020 | Bioorganic & medicinal chemistry letters, 11-15, Volume: 30, Issue:22
| Design, synthesis and evaluation of novel indirubin-based N-hydroxybenzamides, N-hydroxypropenamides and N-hydroxyheptanamides as histone deacetylase inhibitors and antitumor agents. |
| AID1833616 | Cytotoxicity against human HL-60 cells assessed as cell growth inhibition incubated for 72 hrs by CCK8 assay | 2021 | Journal of natural products, 11-26, Volume: 84, Issue:11
| Sublyratins A-O, Labdane-Type Diterpenoids from |
| AID1441895 | Antiproliferative activity against human K562 cells after 48 hrs by MTT assay | 2017 | European journal of medicinal chemistry, Mar-31, Volume: 129 | Design, synthesis, biological evaluation and molecular modeling study of novel macrocyclic bisbibenzyl analogues as antitubulin agents. |
| AID1625416 | Cytotoxicity against human NCI-H460 cells assessed as reduction in cell viability by MTT assay | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4
| Bafilomycins and Odoriferous Sesquiterpenoids from Streptomyces albolongus Isolated from Elephas maximus Feces. |
| AID1612621 | Antiproliferative activity against human taxol-resistant A549/TR cells after 72 hrs by MTT assay | 2019 | European journal of medicinal chemistry, Feb-01, Volume: 163 | Design, synthesis and biological evaluation of quinoline-indole derivatives as anti-tubulin agents targeting the colchicine binding site. |
| AID1902315 | Cytotoxicity against human HeLa cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay | 2022 | European journal of medicinal chemistry, Mar-15, Volume: 232 | Semisynthesis and biological evaluation of (+)-sclerotiorin derivatives as antitumor agents for the treatment of hepatocellular carcinoma. |
| AID734084 | Growth inhibition against human LoVo cells after 72 hrs by inverted microscopy | 2013 | European journal of medicinal chemistry, Apr, Volume: 62 | Synthesis, cytotoxicity and antiplasmodial activity of novel ent-kaurane derivatives. |
| AID490204 | Cytotoxicity against human HepG2 cells by MTT assay | 2010 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 20, Issue:13
| Synthesis of novel beta-carbolines with efficient DNA-binding capacity and potent cytotoxicity. |
| AID1172770 | Anti-proliferative activity against human ACHN cells by XTT assay | 2014 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 24, Issue:22
| Synthesis and SAR studies of bis-chromenone derivatives for anti-proliferative activity against human cancer cells. |
| AID1541624 | Cytotoxicity against human A549 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay | 2019 | Journal of natural products, 12-27, Volume: 82, Issue:12
| Glucoconjugated Monoterpene Indole Alkaloids from |
| AID1751129 | Cytotoxicity against human HT-29 cells assessed as reduction in cell viability by MTT assay | | | |
| AID1783255 | Cytotoxicity against human NCI-H1299 cells assessed as inhibition of proliferation incubated for 72 hrs by MTT assay | | | |
| AID1308430 | Cytotoxicity in rat H9c2 cells assessed as reduction in ROS level at 5 uM incubated for 24 hrs in presence of NAC by DCFDA-AM probe-based fluorimetrical analysis | 2016 | Journal of medicinal chemistry, 05-26, Volume: 59, Issue:10
| H2S-Donating Doxorubicins May Overcome Cardiotoxicity and Multidrug Resistance. |
| AID1880230 | Antiproliferative activity against human NCI-H358 cells assessed as inhibition of cell growth incubated for 48 hrs by CCK8 assay | 2022 | ACS medicinal chemistry letters, May-12, Volume: 13, Issue:5
| Synthesis and Antitumor Activity of Diosgenin Hydroxamic Acid and Quaternary Phosphonium Salt Derivatives. |
| AID1611342 | Binding affinity to human telomeric 7 G-quadruplex DNA assessed as binding constant Kb2 | 2019 | Bioorganic & medicinal chemistry, 12-15, Volume: 27, Issue:24
| Dual mode of binding of anti cancer drug epirubicin to G-quadruplex [d-(TTAGGGT)] |
| AID1505077 | Cytotoxicity against human MCF10A cells after 72 hrs by MTT assay | 2018 | Journal of natural products, 01-26, Volume: 81, Issue:1
| Ophiobolins from the Mangrove Fungus Aspergillus ustus. |
| AID1880232 | Antiproliferative activity against human SW-620 cells assessed as inhibition of cell growth incubated for 48 hrs by CCK8 assay | 2022 | ACS medicinal chemistry letters, May-12, Volume: 13, Issue:5
| Synthesis and Antitumor Activity of Diosgenin Hydroxamic Acid and Quaternary Phosphonium Salt Derivatives. |
| AID473422 | Anticancer activity against human SF295 cells assessed as cell growth inhibition at 10 uM after 48 hrs by SRB assay | 2010 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 20, Issue:7
| Solvent free synthesis, anti-inflammatory and anticancer activity evaluation of tricyclic and tetracyclic benzimidazole derivatives. |
| AID1638226 | Cytotoxicity against human A549 cells after 72 hrs by MTT assay | 2019 | European journal of medicinal chemistry, Mar-01, Volume: 165 | Discovery and synthesis of sulfur-containing 6-substituted 5,8-dimethoxy-1,4-naphthoquinone oxime derivatives as new and potential anti-MDR cancer agents. |
| AID454057 | Cytotoxicity against human DU145 cells at 10 uM by MTT assay | 2009 | Bioorganic & medicinal chemistry, Nov-01, Volume: 17, Issue:21
| Synthesis of isoquinolinone-based tetracycles as poly (ADP-ribose) polymerase-1 (PARP-1) inhibitors. |
| AID1145593 | Cytotoxicity against human HeLa cells assessed as cloning efficiency after 8 hrs | 1976 | Journal of medicinal chemistry, May, Volume: 19, Issue:5
| Stereocontrolled glycosidation of daunomycinone. Synthesis and biological evaluation of 6-hydroxy-L-arabino analogues of antitumor anthracyclines. |
| AID734085 | Growth inhibition against human HeLa cells after 72 hrs by inverted microscopy | 2013 | European journal of medicinal chemistry, Apr, Volume: 62 | Synthesis, cytotoxicity and antiplasmodial activity of novel ent-kaurane derivatives. |
| AID138188 | Compound was evaluated for antitumor activity in mice injected intraperitoneal with leukemia P-388 cells, treated on days 5, 9, and 13 th day at 16 mg/kg | 1981 | Journal of medicinal chemistry, Jun, Volume: 24, Issue:6
| Synthesis and preliminary antitumor evaluation of 5-iminodoxorubicin. |
| AID1308398 | Activity at PgP in human U2OS/DX500 cells assessed as Km of compound measured per mg of protein incubated for 20 mins by fluorimetrical analysis | 2016 | Journal of medicinal chemistry, 05-26, Volume: 59, Issue:10
| H2S-Donating Doxorubicins May Overcome Cardiotoxicity and Multidrug Resistance. |
| AID1490962 | Cytotoxicity against human NCI-H1975 cells after 24 hrs by sulforhodamine B assay | 2017 | Journal of natural products, 05-26, Volume: 80, Issue:5
| Geranylpyrrol A and Piericidin F from Streptomyces sp. CHQ-64 ΔrdmF. |
| AID1671738 | Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay | 2019 | European journal of medicinal chemistry, Mar-15, Volume: 166 | Excellent antitumor and antimetastatic activities based on novel coumarin/pyrazole oxime hybrids. |
| AID1490959 | Cytotoxicity against human HeLa cells after 24 hrs by sulforhodamine B assay | 2017 | Journal of natural products, 05-26, Volume: 80, Issue:5
| Geranylpyrrol A and Piericidin F from Streptomyces sp. CHQ-64 ΔrdmF. |
| AID1637319 | Cytotoxicity against human HeLa cells assessed as reduction in cell viability after 2 days by MTT assay | 2016 | Bioorganic & medicinal chemistry, 10-01, Volume: 24, Issue:19
| In vitro cytotoxicity of novel 2,5,7-tricarbo-substituted indoles derived from 2-amino-5-bromo-3-iodoacetophenone. |
| AID1405493 | Cytotoxicity against human FHC cells | 2018 | European journal of medicinal chemistry, Aug-05, Volume: 156 | Copper(I) oxide nanoparticles catalyzed click chemistry based synthesis of melampomagnolide B-triazole conjugates and their anti-cancer activities. |
| AID1625835 | Antitumor activity against P-gp overexpressing human MCF7/ADR cells xenografted in mouse assessed as tumor growth inhibition at 4 mg/kg, iv qd administered every 2 days measured during compound dosing | 2016 | Journal of medicinal chemistry, 06-23, Volume: 59, Issue:12
| Design, Synthesis, and Evaluation of in Vitro and in Vivo Anticancer Activity of 4-Substituted Coumarins: A Novel Class of Potent Tubulin Polymerization Inhibitors. |
| AID1202749 | Growth inhibition of mouse B16 cells by MTT method | 2015 | Journal of natural products, Feb-27, Volume: 78, Issue:2
| 1,19-seco-Avermectin analogues from a ΔaveCDE mutant Streptomyces avermectinius strain. |
| AID456255 | Cytotoxicity against human HeLa cells after 4 days by ELISA reader assay | 2010 | Bioorganic & medicinal chemistry, Jan-01, Volume: 18, Issue:1
| 2-Thienyl-4-furyl-6-aryl pyridine derivatives: synthesis, topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship study. |
| AID1405488 | Antiproliferative activity against human Bel7402 cells after 72 hrs by MTT assay | 2018 | European journal of medicinal chemistry, Aug-05, Volume: 156 | Copper(I) oxide nanoparticles catalyzed click chemistry based synthesis of melampomagnolide B-triazole conjugates and their anti-cancer activities. |
| AID1378625 | Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay | 2017 | Journal of natural products, 08-25, Volume: 80, Issue:8
| Antifungal and Cytotoxic β-Resorcylic Acid Lactones from a Paecilomyces Species. |
| AID1363193 | Antiproliferative activity against human HCT15 cells after 72 hrs by EZ-CYTOX reagent based assay | 2018 | Bioorganic & medicinal chemistry, 10-01, Volume: 26, Issue:18
| A new phenolic series of indenopyridinone as topoisomerase inhibitors: Design, synthesis, and structure-activity relationships. |
| AID166707 | Inhibition of [3H]uridine incorporation into proliferating L1210 cells. | 1984 | Journal of medicinal chemistry, May, Volume: 27, Issue:5
| Intensely potent morpholinyl anthracyclines. |
| AID1337588 | Antiproliferative activity against human HCT15 cells measured after 72 hrs by CCK8 assay | 2017 | European journal of medicinal chemistry, Jan-05, Volume: 125 | Fluorescein hydrazones: A series of novel non-intercalative topoisomerase IIα catalytic inhibitors induce G1 arrest and apoptosis in breast and colon cancer cells. |
| AID1879216 | Antiproliferative activity against human DU-145 cells assessed as inhibition of cell proliferation | 2022 | Bioorganic & medicinal chemistry letters, 03-15, Volume: 60 | Topoisomerase IIα inhibitory and antiproliferative activity of dihydroxylated 2,6-diphenyl-4-fluorophenylpyridines: Design, synthesis, and structure-activity relationships. |
| AID1637343 | Cytotoxicity against human MCF7 cells assessed as cell viability at 1 uM after 2 days by MTT assay relative to control | 2016 | Bioorganic & medicinal chemistry, 10-01, Volume: 24, Issue:19
| In vitro cytotoxicity of novel 2,5,7-tricarbo-substituted indoles derived from 2-amino-5-bromo-3-iodoacetophenone. |
| AID1172775 | Anti-proliferative activity against human PC3 cells by XTT assay | 2014 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 24, Issue:22
| Synthesis and SAR studies of bis-chromenone derivatives for anti-proliferative activity against human cancer cells. |
| AID1887829 | Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay | 2022 | European journal of medicinal chemistry, Jan-05, Volume: 227 | Structure modification and biological evaluation of indole-chalcone derivatives as anti-tumor agents through dual targeting tubulin and TrxR. |
| AID1481836 | Resistance factor, ratio of IC50 for human K562/ADR cells to IC50 for human K562 cells | 2017 | Journal of medicinal chemistry, 04-13, Volume: 60, Issue:7
| 6-OH-Phenanthroquinolizidine Alkaloid and Its Derivatives Exert Potent Anticancer Activity by Delaying S Phase Progression. |
| AID1435297 | Cytotoxicity against 7 mW/cm'2 irradiated human fibroblasts at 5 uM measured after 20 mins by spectrophotometric method | 2017 | ACS medicinal chemistry letters, Mar-09, Volume: 8, Issue:3
| Light-Regulated NO Release as a Novel Strategy To Overcome Doxorubicin Multidrug Resistance. |
| AID97979 | Dose required to inhibit the RNA synthesis in leukemia L1210 cells | 1981 | Journal of medicinal chemistry, Jun, Volume: 24, Issue:6
| Synthesis and preliminary antitumor evaluation of 5-iminodoxorubicin. |
| AID1308401 | Cytotoxicity in human U2OS/DX580 cells at 5 uM incubated for 24 hrs by LDH release-based spectrofluorimetrical analysis | 2016 | Journal of medicinal chemistry, 05-26, Volume: 59, Issue:10
| H2S-Donating Doxorubicins May Overcome Cardiotoxicity and Multidrug Resistance. |
| AID619821 | Cytotoxicity against human A375 cells by MTT assay | 2011 | European journal of medicinal chemistry, Oct, Volume: 46, Issue:10
| Synthesis and biological evaluation of 1,9-disubstituted β-carbolines as potent DNA intercalating and cytotoxic agents. |
| AID1358348 | Cytotoxicity against human PANC1 cells after 72 hrs under hypoxic condition by MTT assay | 2018 | European journal of medicinal chemistry, May-10, Volume: 151 | Syntheses and anti-pancreatic cancer activities of rakicidin A analogues. |
| AID1441897 | Antiproliferative activity against human HT-29 cells after 48 hrs by MTT assay | 2017 | European journal of medicinal chemistry, Mar-31, Volume: 129 | Design, synthesis, biological evaluation and molecular modeling study of novel macrocyclic bisbibenzyl analogues as antitubulin agents. |
| AID1546805 | Cytotoxicity against human HCT116 cells after 24 hrs by SRB method | 2020 | Journal of natural products, 01-24, Volume: 83, Issue:1
| Prenylated |
| AID1490960 | Cytotoxicity against human NB4 cells after 72 hrs by MTT assay | 2017 | Journal of natural products, 05-26, Volume: 80, Issue:5
| Geranylpyrrol A and Piericidin F from Streptomyces sp. CHQ-64 ΔrdmF. |
| AID1331839 | Cytotoxicity against human HepG2 cells assessed as cell growth inhibition after 48 hrs by SRB assay | 2016 | Journal of natural products, 09-23, Volume: 79, Issue:9
| Isolation of Coralmycins A and B, Potent Anti-Gram Negative Compounds from the Myxobacteria Corallococcus coralloides M23. |
| AID1287953 | Cytotoxicity against human HeLa cells after 3 days by CCK8 assay | 2016 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 26, Issue:7
| Effect of chlorine substituent on cytotoxic activities: Design and synthesis of systematically modified 2,4-diphenyl-5H-indeno[1,2-b]pyridines. |
| AID551376 | Cytotoxicity against human DWD assessed as inhibition of cell growth | 2011 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 21, Issue:1
| An efficient one-pot synthesis of benzothiazolo-4β-anilino-podophyllotoxin congeners: DNA topoisomerase-II inhibition and anticancer activity. |
| AID249856 | Percent control of human mammary adenocarcinoma MCF-7 cell line proliferation at 30 ng/mL | 2004 | Bioorganic & medicinal chemistry letters, Sep-20, Volume: 14, Issue:18
| Formation of squaric acid amides of anthracycline antibiotics. Synthesis and cytotoxic properties. |
| AID1490966 | Cytotoxicity against human HCT116 cells after 24 hrs by sulforhodamine B assay | 2017 | Journal of natural products, 05-26, Volume: 80, Issue:5
| Geranylpyrrol A and Piericidin F from Streptomyces sp. CHQ-64 ΔrdmF. |
| AID1663790 | Inhibition of human DNA topoisomerase 2 catalytic activity using supercoiled pRYG DNA as substrate measured after 45 mins in presence of ATP by agarose gel electrophoresis | 2020 | Bioorganic & medicinal chemistry letters, 07-15, Volume: 30, Issue:14
| Synthesis and evaluation of novel sulfonamide analogues of 6/7-aminoflavones as anticancer agents via topoisomerase II inhibition. |
| AID1326529 | Antiproliferative activity against human ER-positive MCF7 cells measured after 48 hrs by MTT assay | 2016 | European journal of medicinal chemistry, Oct-21, Volume: 122 | Discovery and development of natural product oridonin-inspired anticancer agents. |
| AID1378626 | Cytotoxicity against human A549 cells after 72 hrs by MTT assay | 2017 | Journal of natural products, 08-25, Volume: 80, Issue:8
| Antifungal and Cytotoxic β-Resorcylic Acid Lactones from a Paecilomyces Species. |
| AID1171350 | Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay | 2014 | ACS medicinal chemistry letters, Nov-13, Volume: 5, Issue:11
| Synthesis and biological evaluation of sophoridinol derivatives as a novel family of potential anticancer agents. |
| AID478253 | Cytotoxicity against human HL60 cells after 24 hrs by MTT assay | 2010 | European journal of medicinal chemistry, May, Volume: 45, Issue:5
| Modulation of doxorubicin activity in cancer cells by conjugation with fatty acyl and terpenyl hydrazones. |
| AID1699969 | Antiproliferative activity against human K562 cells by MTT assay | 2020 | Bioorganic & medicinal chemistry letters, 12-15, Volume: 30, Issue:24
| Discovery of thiosemicarbazone-containing compounds with potent anti-proliferation activity against drug-resistant K562/A02 cells. |
| AID548271 | Antiviral activity against Ebolavirus infected in african green monkey COS1 cells assessed as inhibition of viral replication after 32 hrs by luciferase reporter gene assay | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7
| Minigenome-based reporter system suitable for high-throughput screening of compounds able to inhibit Ebolavirus replication and/or transcription. |
| AID650182 | Cytotoxicity against human MDA-MB-231 cells after 48 hrs by MTT assay | 2012 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 22, Issue:5
| Synthesis and evaluation of cytotoxic effects of novel α-methylenelactone tetracyclic diterpenoids. |
| AID1888033 | Antiproliferative activity against human HCT-15 cells after 72 hrs by EZ-Cytox colorimetric assay | 2022 | European journal of medicinal chemistry, Jan-05, Volume: 227 | Identification of new halogen-containing 2,4-diphenyl indenopyridin-5-one derivative as a boosting agent for the anticancer responses of clinically available topoisomerase inhibitors. |
| AID1358361 | Inhibition of ALDH in human PANC1 cells assessed as aldefluor positive cells at 0.5 uM after 72 hrs by aldefluor assay (Rvb = 12.5%) | 2018 | European journal of medicinal chemistry, May-10, Volume: 151 | Syntheses and anti-pancreatic cancer activities of rakicidin A analogues. |
| AID1172771 | Anti-proliferative activity against human HCT15 cells by XTT assay | 2014 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 24, Issue:22
| Synthesis and SAR studies of bis-chromenone derivatives for anti-proliferative activity against human cancer cells. |
| AID1264614 | Cytotoxicity against human A549 cells after 72 hrs by MTT assay | 2015 | Journal of natural products, Nov-25, Volume: 78, Issue:11
| Versixanthones A-F, Cytotoxic Xanthone-Chromanone Dimers from the Marine-Derived Fungus Aspergillus versicolor HDN1009. |
| AID1308435 | Induction of intracellular ROS accumulation in human U2OS/DX30 cells at 5 uM incubated for 24 hrs by DCFDA-AM probe-based fluorimetrical analysis relative to control | 2016 | Journal of medicinal chemistry, 05-26, Volume: 59, Issue:10
| H2S-Donating Doxorubicins May Overcome Cardiotoxicity and Multidrug Resistance. |
| AID1895014 | Anticancer activity against human MCF7 cells assessed as inhibition of cell growth by MTT assay | 2021 | European journal of medicinal chemistry, Aug-05, Volume: 220 | Discovery of cytotoxic natural products from Red Sea sponges: Structure and synthesis. |
| AID580235 | Cytotoxicity against human SGC7901 cells assessed as cell mortality after 20 hrs by MTT assay | 2011 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 21, Issue:5
| Substrate-controlled chemoselective synthesis and potent cytotoxic activity of novel 5,6,7-triarylpyrido[2,3-d]pyrimidin-4-one derivatives. |
| AID1673405 | Antiproliferative activity against drug- resistant human K562/ADR cells | 2019 | Bioorganic & medicinal chemistry, 07-15, Volume: 27, Issue:14
| Design, synthesis, and biological activity evaluation of (-)-6-O-desmethylantofine analogues as potent anti-cancer agents. |
| AID1713808 | Cytotoxicity against human MDA-MB-231 cells assessed as cell growth inhibition measured after 2 days by cell counting kit-8 assay | 2016 | Bioorganic & medicinal chemistry, 11-15, Volume: 24, Issue:22
| Synthesis and topoisomerases inhibitory activity of heteroaromatic chalcones. |
| AID1435286 | Dark toxicity in human M14 cells assessed as increase in nitrite levels at 5 uM measured after 20 mins by Griess reagent based spectrophotometric method | 2017 | ACS medicinal chemistry letters, Mar-09, Volume: 8, Issue:3
| Light-Regulated NO Release as a Novel Strategy To Overcome Doxorubicin Multidrug Resistance. |
| AID592698 | Cytotoxicity against human A549 cells after 48 hrs by sulforhodamine B based ELISA | 2011 | Bioorganic & medicinal chemistry, Apr-01, Volume: 19, Issue:7
| Synthesis of a new 4-aza-2,3-didehydropodophyllotoxin analogues as potent cytotoxic and antimitotic agents. |
| AID478296 | Induction of apoptosis in human 518A2 cells assessed as increase of ratio of Bax to Bcl-2 mRNA expression at 5 uM after 6 to 18 hrs by RT-PCR analysis | 2010 | European journal of medicinal chemistry, May, Volume: 45, Issue:5
| Modulation of doxorubicin activity in cancer cells by conjugation with fatty acyl and terpenyl hydrazones. |
| AID1164700 | Cytotoxicity against human PC3 cells after 24 hrs by MTT assay | 2014 | Journal of natural products, Sep-26, Volume: 77, Issue:9
| Notolutesins A-J, dolabrane-type diterpenoids from the Chinese liverwort Notoscyphus lutescens. |
| AID1337587 | Antiproliferative activity against human DU145 cells measured after 72 hrs by CCK8 assay | 2017 | European journal of medicinal chemistry, Jan-05, Volume: 125 | Fluorescein hydrazones: A series of novel non-intercalative topoisomerase IIα catalytic inhibitors induce G1 arrest and apoptosis in breast and colon cancer cells. |
| AID512164 | Cytotoxicity against human DWD cells after 48 hrs by SRB assay | 2010 | European journal of medicinal chemistry, Sep, Volume: 45, Issue:9
| Synthesis and biological evaluation of cinnamido linked pyrrolo[2,1-c][1,4]benzodiazepines as antimitotic agents. |
| AID376376 | Antitumor activity against human SK MEL28 cells | 1999 | Journal of natural products, Nov, Volume: 62, Issue:11
| Synthesis of 11,12-epoxydrim-8,12-en-11-ol, 11,12-diacetoxydrimane, and warburganal from (-)-sclareol. |
| AID1381567 | Cytotoxicity against human HeLa cells by SRB assay | | | |
| AID122233 | Antitumor activity against mice bearing L1210 leukemia implanted ip on day 0, after treatment with single ip dose 10 mg/kg on day 1. | 1984 | Journal of medicinal chemistry, May, Volume: 27, Issue:5
| Intensely potent morpholinyl anthracyclines. |
| AID587218 | Cytotoxicity against human SW1116 cells assessed as cell viability rate at 10 ug/ml after 24 hrs by MTT assay | 2011 | European journal of medicinal chemistry, Mar, Volume: 46, Issue:3
| Efficient microwave-assisted synthesis of novel 3-aminohexahydrocoumarin derivatives and evaluation on their cytotoxicity. |
| AID1650583 | Antiproliferative activity against human HeLa/Fucci2 cells assessed as inhibition of cell viability incubated for 3 days by MTT assay | 2020 | Bioorganic & medicinal chemistry, 01-15, Volume: 28, Issue:2
| Metachromins X and Y from a marine sponge Spongia sp. and their effects on cell cycle progression. |
| AID633826 | Cytotoxicity against human HeLa cells after 24 hrs by MTT assay | 2012 | Bioorganic & medicinal chemistry, Jan-01, Volume: 20, Issue:1
| Synthesis, antiproliferative activity and genotoxicity of novel anthracene-containing aminophosphonates and a new anthracene-derived Schiff base. |
| AID1706709 | Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability by MTT assay | 2021 | European journal of medicinal chemistry, Jan-01, Volume: 209 | Discovery of lysosome-targeted covalent anticancer agents based on isosteviol skeleton. |
| AID1625736 | Resistance index, ratio of IC50 for beta-tubulin 3 overexpressing human A2780T cells to IC50 for human A2780S cells | 2016 | Journal of medicinal chemistry, 06-23, Volume: 59, Issue:12
| Design, Synthesis, and Evaluation of in Vitro and in Vivo Anticancer Activity of 4-Substituted Coumarins: A Novel Class of Potent Tubulin Polymerization Inhibitors. |
| AID650180 | Cytotoxicity against human PC3 cells after 48 hrs by MTT assay | 2012 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 22, Issue:5
| Synthesis and evaluation of cytotoxic effects of novel α-methylenelactone tetracyclic diterpenoids. |
| AID1441124 | Cytotoxicity against cancer stem cells derived from human BT474 cells assessed as cancer stem cell death at 7.5 uM after 3 days by MTS assay | 2017 | Journal of medicinal chemistry, 03-09, Volume: 60, Issue:5
| Replacing d-Glucosamine with Its l-Enantiomer in Glycosylated Antitumor Ether Lipids (GAELs) Retains Cytotoxic Effects against Epithelial Cancer Cells and Cancer Stem Cells. |
| AID1675627 | Cytotoxicity against human PC-3 cells assessed as reduction in cell viability by SRB assay | 2020 | Journal of natural products, 09-25, Volume: 83, Issue:9
| Monacycliones G-K and |
| AID1498578 | Resistance factor, ratio of IC50 for human MCF7/ADR cells to IC50 for human MCF7 cells | 2018 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 28, Issue:14
| The inhibitory effect of kokusaginine on the growth of human breast cancer cells and MDR-resistant cells is mediated by the inhibition of tubulin assembly. |
| AID1524519 | Antiproliferative activity against human A549 cells measured after 48 hrs by MTT assay | | | |
| AID1608426 | Growth inhibition of human MCF7 cells after 48 hrs by SRB assay | 2019 | European journal of medicinal chemistry, Oct-15, Volume: 180 | Role of sulphur-heterocycles in medicinal chemistry: An update. |
| AID1436220 | Cytotoxicity against human HeLa cells assessed as cell growth at 10'-7 M after 48 hrs by SRB assay relative to control | 2017 | European journal of medicinal chemistry, Jan-27, Volume: 126 | Piperlongumine derived cyclic sulfonamides (sultams): Synthesis and in vitro exploration for therapeutic potential against HeLa cancer cell lines. |
| AID689426 | Cytotoxicity against BALB mouse 3T3 cells after 72 hrs by SRB assay | 2012 | Journal of medicinal chemistry, Jun-14, Volume: 55, Issue:11
| Synthesis and biological evaluation of new amino acid and dipeptide derivatives of neocryptolepine as anticancer agents. |
| AID1633075 | Potency index, ratio of IC50 for human HepG2/ADM cells to IC50 for human HepG2 cells | 2017 | Bioorganic & medicinal chemistry, 10-15, Volume: 25, Issue:20
| A novel delocalized lipophilic cation-chlorambucil conjugate inhibits P-glycoprotein in HepG2/ADM cells. |
| AID1882815 | Antitumor activity against mouse Sarcoma-180 cells xenografted in ip dosed ICR mouse assessed as tumor growth inhibition rate administered daily for 7 days relative to control | 2022 | European journal of medicinal chemistry, May-05, Volume: 235 | Recent advances of antitumor shikonin/alkannin derivatives: A comprehensive overview focusing on structural classification, synthetic approaches, and mechanisms of action. |
| AID94923 | Antitumor activity against L-1210 leukemia cell line in BDF1 mice after injecting 2 mg/kg intraperitoneal dose | 1990 | Journal of medicinal chemistry, Sep, Volume: 33, Issue:9
| Synthesis and antitumor activity of 9-[(carbamoyloxy)alkyl]anthracyclines: a novel class of anthracycline derivatives. |
| AID1185780 | Growth inhibition of human Bcap37 cells after 72 hrs by MTT assay | 2014 | European journal of medicinal chemistry, Sep-12, Volume: 84 | Synthesis and biological evaluation of novel 6-chloro-quinazolin derivatives as potential antitumor agents. |
| AID1398449 | Cytotoxicity against human A549 cells after 24 hrs by MTT assay | 2018 | Bioorganic & medicinal chemistry, 08-07, Volume: 26, Issue:14
| Terpenoids with vasorelaxant effects from the Chinese liverwort Scapania carinthiaca. |
| AID1461758 | Cytotoxicity against human wild-type MCF7 cells after 72 hrs | 2017 | Bioorganic & medicinal chemistry, 09-01, Volume: 25, Issue:17
| Recent synthetic and medicinal perspectives of tryptanthrin. |
| AID478300 | Induction of apoptosis in human 518A2 cells assessed as increase of Bax mRNA expression at 5 uM up to 24 hrs by Western blot analysis | 2010 | European journal of medicinal chemistry, May, Volume: 45, Issue:5
| Modulation of doxorubicin activity in cancer cells by conjugation with fatty acyl and terpenyl hydrazones. |
| AID1168507 | Cytotoxicity against human A172 cells by MTT assay | 2014 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 24, Issue:22
| Synthesis and biological evaluation of a novel class of coumarin derivatives. |
| AID566856 | Cytotoxicity against human HL60 cells at 30 uM after 48 hrs by MTT assay | 2010 | Journal of natural products, Dec-27, Volume: 73, Issue:12
| Cytotoxic triterpenoids from Maytenus retusa. |
| AID1435965 | Cytotoxicity against human MCF7 cells assessed as growth inhibition at 10 uM measured after 72 hrs by CCK-8 assay relative to control | | | |
| AID1577567 | Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability after 24 hrs by CCK8 assay | | | |
| AID1435307 | Dark toxicity against human fibroblasts at 5 uM measured after 20 mins by spectrophotometric method | 2017 | ACS medicinal chemistry letters, Mar-09, Volume: 8, Issue:3
| Light-Regulated NO Release as a Novel Strategy To Overcome Doxorubicin Multidrug Resistance. |
| AID1428413 | Cytotoxicity against human HeLa cells assessed as growth inhibition after 72 hrs by SRB assay | | | |
| AID1504836 | Cytotoxicity against human MCF7 cells assessed as reduction in cell viability by MTT assay | 2017 | Journal of natural products, 12-22, Volume: 80, Issue:12
| Bibenzyl-Based Meroterpenoid Enantiomers from the Chinese Liverwort Radula sumatrana. |
| AID1907348 | Cytotoxic activity against human MCF-10A assessed as inhibition of cell growth incubated for 48 hrs by MTT assay | 2022 | European journal of medicinal chemistry, Jun-05, Volume: 236 | Synthesis and structure-activity relationship study of a potent MHO7 analogue as potential anti-triple negative breast cancer agent. |
| AID1906032 | Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay | 2022 | European journal of medicinal chemistry, May-05, Volume: 235 | Development of oxoisoaporphine derivatives with topoisomerase I inhibition and reversal of multidrug resistance in breast cancer MCF-7/ADR cells. |
| AID478263 | Cytotoxicity against human topotecan-resistant MCF7 cells after 72 hrs by MTT assay in presence of 1.2 mM BCRP inhibitor fumitremorgin C | 2010 | European journal of medicinal chemistry, May, Volume: 45, Issue:5
| Modulation of doxorubicin activity in cancer cells by conjugation with fatty acyl and terpenyl hydrazones. |
| AID1504838 | Cytotoxicity against human SMMC7721 cells assessed as reduction in cell viability by MTT assay | 2017 | Journal of natural products, 12-22, Volume: 80, Issue:12
| Bibenzyl-Based Meroterpenoid Enantiomers from the Chinese Liverwort Radula sumatrana. |
| AID1543241 | Cytotoxicity in human HepG2 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay | 2019 | Journal of natural products, 07-26, Volume: 82, Issue:7
| Prenylated Bibenzyls from the Chinese Liverwort |
| AID1374096 | Antiproliferative activity against human T47D cells incubated for 72 hrs by CCK8 assay | 2018 | Bioorganic & medicinal chemistry letters, 02-15, Volume: 28, Issue:4
| Design, synthesis, and structure-activity relationships of new benzofuro[3,2-b]pyridin-7-ols as DNA topoisomerase II inhibitors. |
| AID512017 | Cytotoxicity against human A549 cells after 48 hrs by SRB assay | 2010 | European journal of medicinal chemistry, Sep, Volume: 45, Issue:9
| Synthesis and biological evaluation of cinnamido linked pyrrolo[2,1-c][1,4]benzodiazepines as antimitotic agents. |
| AID1637342 | Cytotoxicity against human MCF7 cells assessed as cell viability at 10 uM after 2 days by MTT assay relative to control | 2016 | Bioorganic & medicinal chemistry, 10-01, Volume: 24, Issue:19
| In vitro cytotoxicity of novel 2,5,7-tricarbo-substituted indoles derived from 2-amino-5-bromo-3-iodoacetophenone. |
| AID1352062 | Cytotoxicity against human K562/A02 cells assessed as reduction in cell viability after 72 hrs by MTS assay | 2018 | European journal of medicinal chemistry, Feb-10, Volume: 145 | Synthesis and biological evaluation of bifendate derivatives bearing 6,7-dihydro-dibenzo[c,e]azepine scaffold as potential P-glycoprotein and tumor metastasis inhibitors. |
| AID1637347 | Cytotoxicity against human HeLa cells assessed as cell viability at 20 uM after 2 days by MTT assay relative to control | 2016 | Bioorganic & medicinal chemistry, 10-01, Volume: 24, Issue:19
| In vitro cytotoxicity of novel 2,5,7-tricarbo-substituted indoles derived from 2-amino-5-bromo-3-iodoacetophenone. |
| AID473261 | Anticancer activity against human MCF7 cells assessed as cell growth inhibition at 10 uM after 48 hrs by SRB assay | 2010 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 20, Issue:7
| Solvent free synthesis, anti-inflammatory and anticancer activity evaluation of tricyclic and tetracyclic benzimidazole derivatives. |
| AID1370455 | Cytostatic activity against human HepG2 cells assessed as cell viability at 0.02 to 70 uM after 48 hrs by MTS assay | 2018 | Bioorganic & medicinal chemistry letters, 02-01, Volume: 28, Issue:3
| Synthesis and biological evaluation of novel doxorubicin-containing ASGP-R-targeted drug-conjugates. |
| AID1431560 | Selectivity ratio of IC50 for human KG1a cells to IC50 for human HL60 cells | 2017 | European journal of medicinal chemistry, Feb-15, Volume: 127 | Synthesis and anti-acute myeloid leukemia activity of C-14 modified parthenolide derivatives. |
| AID1486981 | Cytotoxicity against human K562 cells after 48 hrs by MTT assay | 2017 | Bioorganic & medicinal chemistry, 08-01, Volume: 25, Issue:15
| Synthesis and biological evaluation of JL-A7 derivatives as potent ABCB1 inhibitors. |
| AID587221 | Cytotoxicity against human SGC7901 cells after 20 hrs by MTT assay | 2011 | European journal of medicinal chemistry, Mar, Volume: 46, Issue:3
| Efficient microwave-assisted synthesis of novel 3-aminohexahydrocoumarin derivatives and evaluation on their cytotoxicity. |
| AID1188101 | Cytotoxicity against human HCT116 cells assessed as growth inhibition at 1 uM after 48 hrs by sulforhodamine B assay | 2014 | European journal of medicinal chemistry, Oct-06, Volume: 85 | Chalcone based azacarboline analogues as novel antitubulin agents: design, synthesis, biological evaluation and molecular modelling studies. |
| AID1374097 | Antiproliferative activity against human HeLa cells incubated for 72 hrs by CCK8 assay | 2018 | Bioorganic & medicinal chemistry letters, 02-15, Volume: 28, Issue:4
| Design, synthesis, and structure-activity relationships of new benzofuro[3,2-b]pyridin-7-ols as DNA topoisomerase II inhibitors. |
| AID1875134 | Growth inhibition of human MDA-MB-231 cells by SRB assay | 2022 | Journal of natural products, 09-23, Volume: 85, Issue:9
| Aspersterols A-D, Ergostane-Type Sterols with an Unusual Unsaturated Side Chain from the Deep-Sea-Derived Fungus |
| AID1905035 | Antiproliferative activity against human A2780 cells assessed as cell viability incubated for 48 hrs by MTT assay | 2022 | Journal of medicinal chemistry, 03-24, Volume: 65, Issue:6
| Discovery of a Novel Stilbene Derivative as a Microtubule Targeting Agent Capable of Inducing Cell Ferroptosis. |
| AID1288092 | Cytotoxicity against human HCT15 cells after 48 hrs by CCK8 assay | 2016 | European journal of medicinal chemistry, May-04, Volume: 113 | A new series of 2-phenol-4-aryl-6-chlorophenyl pyridine derivatives as dual topoisomerase I/II inhibitors: Synthesis, biological evaluation and 3D-QSAR study. |
| AID718787 | Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay | 2012 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 22, Issue:24
| Angucyclines from an insect-derived actinobacterium Amycolatopsis sp. HCa1 and their cytotoxic activity. |
| AID1887103 | Cytotoxicity against human ASPC1 cells assessed as reduction in cell viability by SRB assay | | | |
| AID1617196 | Cytotoxicity against human MDA-MB-231 cells assessed as cell growth inhibition measured after 48 hrs by SRB assay | 2019 | Journal of natural products, 11-22, Volume: 82, Issue:11
| Resorcinosides A and B, Glycosylated Alkylresorcinols from a Marine-Derived Strain of the Fungus |
| AID1611341 | Binding affinity to human telomeric 7 G-quadruplex DNA assessed as binding constant Kb1 | 2019 | Bioorganic & medicinal chemistry, 12-15, Volume: 27, Issue:24
| Dual mode of binding of anti cancer drug epirubicin to G-quadruplex [d-(TTAGGGT)] |
| AID103256 | Cytotoxicity against MCF-7R cell line in the purdue cell culture screen was determined | 1999 | Bioorganic & medicinal chemistry letters, Feb-08, Volume: 9, Issue:3
| On the relationship of OSW-1 to the cephalostatins. |
| AID111014 | Myocardial histopathological effect in female mice treated iv at a dose of 4.0 mg/kg twice weekly on weeks 1, 2, 5, 6 & 7 is measured as no. of mice with myocardial vacuolization/no. of mice examined; Inactive | 1984 | Journal of medicinal chemistry, May, Volume: 27, Issue:5
| Intensely potent morpholinyl anthracyclines. |
| AID1337470 | Inhibition of human DNA topoisomerase-1 at 20 uM using supercoiled pBR322 DNA as substrate after 30 mins by ethidium bromide staining based agarose gel electrophoresis relative to control | 2017 | European journal of medicinal chemistry, Jan-05, Volume: 125 | Novel 2-aryl-4-(4'-hydroxyphenyl)-5H-indeno[1,2-b]pyridines as potent DNA non-intercalative topoisomerase catalytic inhibitors. |
| AID1907349 | Selectivity index, ratio of IC50 for Cytotoxic activity against human MCF-10A cells to IC50 for antiproliferative activity against human MDA-MB-231 cells | 2022 | European journal of medicinal chemistry, Jun-05, Volume: 236 | Synthesis and structure-activity relationship study of a potent MHO7 analogue as potential anti-triple negative breast cancer agent. |
| AID1308432 | Cytotoxicity in rat H9c2 cells assessed as reduction in ROS level at 5 uM incubated for 24 hrs in presence of dexrazoxane by LDH release-based spectrofluorimetrical analysis relative to control | 2016 | Journal of medicinal chemistry, 05-26, Volume: 59, Issue:10
| H2S-Donating Doxorubicins May Overcome Cardiotoxicity and Multidrug Resistance. |
| AID1696720 | Cytotoxicity against human HeLa cells assessed as reduction in cell viability after 48 hrs by SRB assay | 2020 | Journal of natural products, 09-25, Volume: 83, Issue:9
| Dimeric Tetrahydroanthracene Regioisomers and Their Monomeric Precursor Produced by |
| AID549505 | Cytotoxicity against human A549 cells after 48 hrs by MTT assay | 2011 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 21, Issue:1
| Efficient synthesis and biological evaluation of epiceanothic acid and related compounds. |
| AID1386172 | Cytotoxicity against human A2780 cells after 48 hrs by MTT assay | 2018 | Journal of natural products, 09-28, Volume: 81, Issue:9
| Cytotoxic p-Terphenyls from the Endolichenic Fungus Floricola striata. |
| AID1378628 | Antifungal activity against Peronophythora litchii after 8 hrs by conidial germination assay | 2017 | Journal of natural products, 08-25, Volume: 80, Issue:8
| Antifungal and Cytotoxic β-Resorcylic Acid Lactones from a Paecilomyces Species. |
| AID1899073 | Antiproliferative activity against human K562 cells measured after 72 hrs by SRB assay | | | |
| AID380471 | Cytotoxicity against MDR1-G185 overexpressing human HeLa cells by MTT assay | 2006 | Journal of natural products, Mar, Volume: 69, Issue:3
| Sylviside, a diterpene glucoside derivative from Gnaphalium sylvaticum. |
| AID1227996 | Cytotoxic activity against human BGC823 cells by MTT method | 2015 | Journal of natural products, Apr-24, Volume: 78, Issue:4
| Dimeric Abietane Diterpenoids and Sesquiterpenoid Lactones from Teucrium viscidum. |
| AID380470 | Cytotoxicity against wild type human HeLa cells by MTT assay | 2006 | Journal of natural products, Mar, Volume: 69, Issue:3
| Sylviside, a diterpene glucoside derivative from Gnaphalium sylvaticum. |
| AID478277 | Induction of apoptosis in human 518A2 cells assessed as increase of caspase 9 activity at 5 uM after 8 to 12 hrs by luminometric assay | 2010 | European journal of medicinal chemistry, May, Volume: 45, Issue:5
| Modulation of doxorubicin activity in cancer cells by conjugation with fatty acyl and terpenyl hydrazones. |
| AID1426656 | Resistant factor, ratio of IC50 for P-gp overexpressing/drug resistant human K562/A02 cells to IC50 for human K562 cells | 2017 | Journal of medicinal chemistry, 02-09, Volume: 60, Issue:3
| Potent Inhibition of Nitric Oxide-Releasing Bifendate Derivatives against Drug-Resistant K562/A02 Cells in Vitro and in Vivo. |
| AID1673406 | Antiproliferative activity against human K562 cells | 2019 | Bioorganic & medicinal chemistry, 07-15, Volume: 27, Issue:14
| Design, synthesis, and biological activity evaluation of (-)-6-O-desmethylantofine analogues as potent anti-cancer agents. |
| AID150546 | In vitro inhibitory activity against cancerous P388 cell line | 2004 | Journal of medicinal chemistry, Jan-29, Volume: 47, Issue:3
| A new aliphatic amino prodrug system for the delivery of small molecules and proteins utilizing novel PEG derivatives. |
| AID1625718 | Antiproliferative activity against human HCT8 cells after 24 hrs by MTT assay | 2016 | Journal of medicinal chemistry, 06-23, Volume: 59, Issue:12
| Design, Synthesis, and Evaluation of in Vitro and in Vivo Anticancer Activity of 4-Substituted Coumarins: A Novel Class of Potent Tubulin Polymerization Inhibitors. |
| AID1268504 | Cytotoxicity against human HepG2 cells after 48 hrs by SRB assay | 2016 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 26, Issue:2
| Identification of a novel class of quinoline-oxadiazole hybrids as anti-tuberculosis agents. |
| AID138189 | Compound was evaluated for antitumor activity in mice injected intraperitoneal with leukemia P-388 cells, treated on days 5, 9, and 13 th day at 1 mg/kg | 1981 | Journal of medicinal chemistry, Jun, Volume: 24, Issue:6
| Synthesis and preliminary antitumor evaluation of 5-iminodoxorubicin. |
| AID1408891 | Cytotoxicity against human DU145 cells assessed as reduction in cell viability after 48 hrs by MTT assay | 2018 | European journal of medicinal chemistry, Oct-05, Volume: 158 | Discovery of novel human inosine 5'-monophosphate dehydrogenase 2 (hIMPDH2) inhibitors as potential anticancer agents. |
| AID1815017 | Cytotoxicity against human HCT-116 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay | 2021 | Journal of natural products, 08-27, Volume: 84, Issue:8
| Cryptoyunnanones A-H, Complex Flavanones from |
| AID478295 | Induction of apoptosis in human HL60 cells assessed as increase of ratio of Bax to Bcl-2 mRNA expression at 5 uM after 6 to 18 hrs by RT-PCR analysis | 2010 | European journal of medicinal chemistry, May, Volume: 45, Issue:5
| Modulation of doxorubicin activity in cancer cells by conjugation with fatty acyl and terpenyl hydrazones. |
| AID1762048 | Cytotoxicity against human A549 cells assessed as inhibition of cell proliferation after 72 hrs by MTT assay | 2021 | Bioorganic & medicinal chemistry letters, 05-15, Volume: 40 | One pot synthesis, in silico study and evaluation of some novel flavonoids as potent topoisomerase II inhibitors. |
| AID484656 | Cytotoxicity against human HOP62 cells after 48 hrs by SRB assay | 2010 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 20, Issue:11
| Synthesis, anticancer activity and apoptosis inducing ability of anthranilamide-PBD conjugates. |
| AID1638224 | Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay | 2019 | European journal of medicinal chemistry, Mar-01, Volume: 165 | Discovery and synthesis of sulfur-containing 6-substituted 5,8-dimethoxy-1,4-naphthoquinone oxime derivatives as new and potential anti-MDR cancer agents. |
| AID1281576 | Antiproliferative activity against human T47D cells assessed as reduction in cell viability after 96 hrs by sulforhodamine B assay | 2016 | European journal of medicinal chemistry, Mar-23, Volume: 111 | Synthesis and biological evaluation of D-ring fused 1,2,3-thiadiazole dehydroepiandrosterone derivatives as antitumor agents. |
| AID1441110 | Cytotoxicity against human BT474 cells assessed as cell death at 2 to 25 times CC50 after 48 hrs by MTS assay | 2017 | Journal of medicinal chemistry, 03-09, Volume: 60, Issue:5
| Replacing d-Glucosamine with Its l-Enantiomer in Glycosylated Antitumor Ether Lipids (GAELs) Retains Cytotoxic Effects against Epithelial Cancer Cells and Cancer Stem Cells. |
| AID1227995 | Cytotoxic activity against human HepG2 cells by MTT method | 2015 | Journal of natural products, Apr-24, Volume: 78, Issue:4
| Dimeric Abietane Diterpenoids and Sesquiterpenoid Lactones from Teucrium viscidum. |
| AID478297 | Induction of apoptosis in human HL60 cells assessed as increase of Bcl-2 mRNA expression at 5 uM up to 24 hrs by Western blot analysis | 2010 | European journal of medicinal chemistry, May, Volume: 45, Issue:5
| Modulation of doxorubicin activity in cancer cells by conjugation with fatty acyl and terpenyl hydrazones. |
| AID509754 | Cytotoxicity against human KB cells after 48 hrs by MTT assay | 2010 | Bioorganic & medicinal chemistry, Sep-15, Volume: 18, Issue:18
| Bisbibenzyl derivatives sensitize vincristine-resistant KB/VCR cells to chemotherapeutic agents by retarding P-gp activity. |
| AID1594692 | Cytotoxicity in human HepG2 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay | 2019 | Journal of natural products, 06-28, Volume: 82, Issue:6
| Asperunguisins A-F, Cytotoxic Asperane Sesterterpenoids from the Endolichenic Fungus Aspergillus unguis. |
| AID1459361 | Cytotoxicity against human MG63 cells by MTT assay | 2016 | Journal of natural products, 10-28, Volume: 79, Issue:10
| Bissubvilides A and B, Cembrane-Capnosane Heterodimers from the Soft Coral Sarcophyton subviride. |
| AID248714 | Concentration required to inhibit proliferation of human mammary adenocarcinoma MCF-7 cell line was determined using MTT assay | 2004 | Bioorganic & medicinal chemistry letters, Sep-20, Volume: 14, Issue:18
| Formation of squaric acid amides of anthracycline antibiotics. Synthesis and cytotoxic properties. |
| AID1401031 | Selectivity ratio of GI50 for human MCF7 cells to GI50 for human MCF7/ADR cells | 2017 | European journal of medicinal chemistry, Dec-01, Volume: 141 | Synthesis, anticancer evaluation and pharmacokinetic study of novel 10-O-phenyl ethers of dihydroartemisinin. |
| AID1431559 | Cytotoxicity against human HL60 cells assessed as decrease in cell proliferation after 48 hrs by MTT assay | 2017 | European journal of medicinal chemistry, Feb-15, Volume: 127 | Synthesis and anti-acute myeloid leukemia activity of C-14 modified parthenolide derivatives. |
| AID1890788 | Cytotoxicity against human NCI-H23 cells assessed as cell growth inhibition incubated for 48 hrs by SRB method | 2022 | Journal of natural products, 04-22, Volume: 85, Issue:4
| Isolation, Structure Determination, and Semisynthesis of Diphenazine Compounds from a Deep-Sea-Derived Strain of the Fungus |
| AID1405490 | Antiproliferative activity against human PANC1 cells after 72 hrs by MTT assay | 2018 | European journal of medicinal chemistry, Aug-05, Volume: 156 | Copper(I) oxide nanoparticles catalyzed click chemistry based synthesis of melampomagnolide B-triazole conjugates and their anti-cancer activities. |
| AID689429 | Cytotoxicity against human LoVo cells after 72 hrs by SRB assay | 2012 | Journal of medicinal chemistry, Jun-14, Volume: 55, Issue:11
| Synthesis and biological evaluation of new amino acid and dipeptide derivatives of neocryptolepine as anticancer agents. |
| AID1390170 | Antiproliferative activity against human HeLa cells after 72 hrs by CCK-8 assay | 2018 | Bioorganic & medicinal chemistry, 05-01, Volume: 26, Issue:8
| Synthesis and SAR study of new hydroxy and chloro-substituted 2,4-diphenyl 5H-chromeno[4,3-b]pyridines as selective topoisomerase IIα-targeting anticancer agents. |
| AID333312 | Cytotoxicity against human HL60 cells after 72 hrs by MTT assay | 2004 | Journal of natural products, Sep, Volume: 67, Issue:9
| Cytotoxic constituents of roots of Chaerophyllum hirsutum. |
| AID1711795 | Antiproliferative activity against human Bel-7402 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay | 2016 | Bioorganic & medicinal chemistry letters, 06-15, Volume: 26, Issue:12
| Novel anticancer oridonin derivatives possessing a diazen-1-ium-1,2-diolate nitric oxide donor moiety: Design, synthesis, biological evaluation and nitric oxide release studies. |
| AID1543245 | Cytotoxicity in human SMMC7721 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay | 2019 | Journal of natural products, 07-26, Volume: 82, Issue:7
| Prenylated Bibenzyls from the Chinese Liverwort |
| AID1363194 | Antiproliferative activity against human T47D cells after 72 hrs by EZ-CYTOX reagent based assay | 2018 | Bioorganic & medicinal chemistry, 10-01, Volume: 26, Issue:18
| A new phenolic series of indenopyridinone as topoisomerase inhibitors: Design, synthesis, and structure-activity relationships. |
| AID1566583 | Cytotoxicity against human Bcap37 cells | 2019 | European journal of medicinal chemistry, Sep-01, Volume: 177 | Developments in the anticancer activity of structurally modified curcumin: An up-to-date review. |
| AID1905056 | Antiproliferative activity against human adriamycin-resistant A549/ADR cells assessed as cell viability incubated for 48 hrs by MTT assay | 2022 | Journal of medicinal chemistry, 03-24, Volume: 65, Issue:6
| Discovery of a Novel Stilbene Derivative as a Microtubule Targeting Agent Capable of Inducing Cell Ferroptosis. |
| AID1879219 | Antiproliferative activity against human HeLa cells assessed as inhibition of cell proliferation | 2022 | Bioorganic & medicinal chemistry letters, 03-15, Volume: 60 | Topoisomerase IIα inhibitory and antiproliferative activity of dihydroxylated 2,6-diphenyl-4-fluorophenylpyridines: Design, synthesis, and structure-activity relationships. |
| AID1875131 | Growth inhibition of human NCI-H23 cells by SRB assay | 2022 | Journal of natural products, 09-23, Volume: 85, Issue:9
| Aspersterols A-D, Ergostane-Type Sterols with an Unusual Unsaturated Side Chain from the Deep-Sea-Derived Fungus |
| AID510625 | Cytotoxicity against human MCF7 cells after 4 days by MTT assay | 2010 | European journal of medicinal chemistry, Sep, Volume: 45, Issue:9
| Synthesis and pharmacological evaluation of new methyloxiranylmethoxyxanthone analogues. |
| AID1437481 | Cytotoxicity against human HeLa cells assessed as reduction in cell viability by SRB assay | 2017 | Journal of natural products, 01-27, Volume: 80, Issue:1
| Penicisulfuranols A-F, Alkaloids from the Mangrove Endophytic Fungus Penicillium janthinellum HDN13-309. |
| AID478298 | Induction of apoptosis in human HL60 cells assessed as increase of Bax mRNA expression at 5 uM up to 24 hrs by Western blot analysis | 2010 | European journal of medicinal chemistry, May, Volume: 45, Issue:5
| Modulation of doxorubicin activity in cancer cells by conjugation with fatty acyl and terpenyl hydrazones. |
| AID1612620 | Drug resistance index, ratio of IC50 for taxol-resistant human HCT8/T cells to IC50 for human HCT8 cells | 2019 | European journal of medicinal chemistry, Feb-01, Volume: 163 | Design, synthesis and biological evaluation of quinoline-indole derivatives as anti-tubulin agents targeting the colchicine binding site. |
| AID1524518 | Antiproliferative activity against human MCF7 cells measured after 48 hrs by MTT assay | | | |
| AID1594691 | Cytotoxicity in human SMMC7721 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay | 2019 | Journal of natural products, 06-28, Volume: 82, Issue:6
| Asperunguisins A-F, Cytotoxic Asperane Sesterterpenoids from the Endolichenic Fungus Aspergillus unguis. |
| AID378842 | Cytotoxicity against human VA13 cells | 2006 | Journal of natural products, Oct, Volume: 69, Issue:10
| Bioactive guaianolides from siyekucai (Ixeris chinensis). |
| AID1757284 | Antiproliferative activity against VCR resistant human K562/VCR cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay | 2021 | European journal of medicinal chemistry, Apr-15, Volume: 216 | Discovery of novel N-benzylbenzamide derivatives as tubulin polymerization inhibitors with potent antitumor activities. |
| AID484659 | Cytotoxicity against human DWD cells after 48 hrs by SRB assay | 2010 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 20, Issue:11
| Synthesis, anticancer activity and apoptosis inducing ability of anthranilamide-PBD conjugates. |
| AID510626 | Cytotoxicity against human HCT116 cells after 4 days by MTT assay | 2010 | European journal of medicinal chemistry, Sep, Volume: 45, Issue:9
| Synthesis and pharmacological evaluation of new methyloxiranylmethoxyxanthone analogues. |
| AID1441112 | Cytotoxicity against human PC3 cells assessed as cell death at 2 to 25 times CC50 after 48 hrs by MTS assay | 2017 | Journal of medicinal chemistry, 03-09, Volume: 60, Issue:5
| Replacing d-Glucosamine with Its l-Enantiomer in Glycosylated Antitumor Ether Lipids (GAELs) Retains Cytotoxic Effects against Epithelial Cancer Cells and Cancer Stem Cells. |
| AID1346987 | P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5
| A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID1296008 | Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening | 2020 | SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1
| Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening. |
| AID1346986 | P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5
| A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID1347124 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for RD cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347082 | qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lassa (LASV) Arenavirus: LASV Primary Screen - GLuc reporter signal | 2020 | Antiviral research, 01, Volume: 173 | A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity. |
| AID1508630 | Primary qHTS for small molecule stabilizers of the endoplasmic reticulum resident proteome: Secreted ER Calcium Modulated Protein (SERCaMP) assay | 2021 | Cell reports, 04-27, Volume: 35, Issue:4
| A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. |
| AID1347104 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for RD cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347094 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for BT-37 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347089 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for TC32 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347097 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Saos-2 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347128 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for OHS-50 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347099 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for NB1643 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347100 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for LAN-5 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347129 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for SK-N-SH cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347407 | qHTS to identify inhibitors of the type 1 interferon - major histocompatibility complex class I in skeletal muscle: primary screen against the NCATS Pharmaceutical Collection | 2020 | ACS chemical biology, 07-17, Volume: 15, Issue:7
| High-Throughput Screening to Identify Inhibitors of the Type I Interferon-Major Histocompatibility Complex Class I Pathway in Skeletal Muscle. |
| AID1347106 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for control Hh wild type fibroblast cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347137 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Orthogonal 3D viability screen for Daoy cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347140 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Orthogonal 3D viability screen for MG 63 (6-TG R) cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347095 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for NB-EBc1 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347108 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Rh41 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347107 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Rh30 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347141 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Orthogonal 3D viability screen for RD cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347136 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Orthogonal 3D viability screen for SJ-GBM2 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347112 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for BT-12 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347126 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for Rh30 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347111 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for SK-N-MC cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347113 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for LAN-5 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347122 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for U-2 OS cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347115 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for NB-EBc1 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347424 | RapidFire Mass Spectrometry qHTS Assay for Modulators of WT P53-Induced Phosphatase 1 (WIP1) | 2019 | The Journal of biological chemistry, 11-15, Volume: 294, Issue:46
| Physiologically relevant orthogonal assays for the discovery of small-molecule modulators of WIP1 phosphatase in high-throughput screens. |
| AID1347121 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for control Hh wild type fibroblast cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347092 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for A673 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347119 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for MG 63 (6-TG R) cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347114 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for DAOY cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347110 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for A673 cells) | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347117 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for BT-37 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347118 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for TC32 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347138 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Orthogonal 3D caspase screen for TC32 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347116 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for SJ-GBM2 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347105 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for MG 63 (6-TG R) cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347096 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for U-2 OS cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347093 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SK-N-MC cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347101 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for BT-12 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347086 | qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lymphocytic Choriomeningitis Arenaviruses (LCMV): LCMV Primary Screen - GLuc reporter signal | 2020 | Antiviral research, 01, Volume: 173 | A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity. |
| AID1347127 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for Saos-2 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347154 | Primary screen GU AMC qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1347109 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for NB1643 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347139 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Orthogonal 3D viability screen for TC32 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347103 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for OHS-50 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347091 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SJ-GBM2 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347090 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for DAOY cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347083 | qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lassa (LASV) Arenavirus: Viability assay - alamar blue signal for LASV Primary Screen | 2020 | Antiviral research, 01, Volume: 173 | A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity. |
| AID1347135 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Orthogonal 3D viability screen for SK-N-SH cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347098 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SK-N-SH cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347425 | Rhodamine-PBP qHTS Assay for Modulators of WT P53-Induced Phosphatase 1 (WIP1) | 2019 | The Journal of biological chemistry, 11-15, Volume: 294, Issue:46
| Physiologically relevant orthogonal assays for the discovery of small-molecule modulators of WIP1 phosphatase in high-throughput screens. |
| AID1347102 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Rh18 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347123 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for Rh41 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347125 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for Rh18 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID588519 | A screen for compounds that inhibit viral RNA polymerase binding and polymerization activities | 2011 | Antiviral research, Sep, Volume: 91, Issue:3
| High-throughput screening identification of poliovirus RNA-dependent RNA polymerase inhibitors. |
| AID540299 | A screen for compounds that inhibit the MenB enzyme of Mycobacterium tuberculosis | 2010 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 20, Issue:21
| Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |