Roles > EC 1.8.1.9 (thioredoxin reductase) inhibitor
Page last updated: 2024-08-05 15:44:00

EC 1.8.1.9 (thioredoxin reductase) inhibitor

An EC 1.8.1.* (oxidoreductase acting on sulfur group of donors, NAD+ or NADP+ as acceptor) inhibitor that interferes with the action of thioredoxin reductase (EC 1.8.1.9).

ChEBI ID: 64670

Members (2)

MemberDefinitionClass
curcuminA beta-diketone that is methane in which two of the hydrogens are substituted by feruloyl groups. A natural dyestuff found in the root of Curcuma longa.curcumin
manumycinA polyketide with formula C31H38N2O7 initially isolated from Streptomyces parvulus as a result of a random screening program for farnesyl transferase (FTase) inhibitors. It is a natural product that exhibits anticancer and antibiotic properties.manumycin A

Research

Studies (16,074)

TimeframeStudies, Drugs with This Role(%)All Drugs %
pre-199086 (0.54)18.7374
1990's342 (2.13)18.2507
2000's2,358 (14.67)29.6817
2010's8,704 (54.15)24.3611
2020's4,584 (28.52)2.80

Study Types

Publication TypeStudies, Drugs with this Role (%)All Drugs (%)
Trials593 (3.60%)5.53%
Reviews1,747 (10.59%)6.00%
Case Studies60 (0.36%)4.05%
Observational6 (0.04%)0.25%
Other14,089 (85.41%)84.16%

Protein Targets (227)

Potency Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1Homo sapiens (human)Potency26.968012
15-lipoxygenase, partialHomo sapiens (human)Potency14.219112
acetylcholinesteraseHomo sapiens (human)Potency63.674034
activating transcription factor 6Homo sapiens (human)Potency35.653422
aldehyde dehydrogenase 1 family, member A1Homo sapiens (human)Potency18.548212
Alpha-synucleinHomo sapiens (human)Potency18.854112
apical membrane antigen 1, AMA1Plasmodium falciparum 3D7Potency7.079511
AR proteinHomo sapiens (human)Potency23.9205918
aryl hydrocarbon receptorHomo sapiens (human)Potency31.572536
ATAD5 protein, partialHomo sapiens (human)Potency29.092911
Ataxin-2Homo sapiens (human)Potency44.153412
ATPase family AAA domain-containing protein 5Homo sapiens (human)Potency48.369624
Bloom syndrome protein isoform 1Homo sapiens (human)Potency25.118911
bromodomain adjacent to zinc finger domain 2BHomo sapiens (human)Potency39.810711
caspase 7, apoptosis-related cysteine proteaseHomo sapiens (human)Potency27.472711
caspase-1 isoform alpha precursorHomo sapiens (human)Potency23.735812
caspase-3Homo sapiens (human)Potency27.472711
Caspase-7Homo sapiens (human)Potency12.589311
Cellular tumor antigen p53Homo sapiens (human)Potency18.286137
cellular tumor antigen p53 isoform aHomo sapiens (human)Potency39.810722
Chain A, 2-oxoglutarate OxygenaseHomo sapiens (human)Potency35.481312
Chain A, ATP-DEPENDENT DNA HELICASE Q1Homo sapiens (human)Potency35.481311
Chain A, Breast cancer type 1 susceptibility proteinHomo sapiens (human)Potency5.011913
Chain A, CruzipainTrypanosoma cruziPotency31.622811
Chain A, Ferritin light chainEquus caballus (horse)Potency19.351212
Chain A, HADH2 proteinHomo sapiens (human)Potency17.802022
Chain A, JmjC domain-containing histone demethylation protein 3AHomo sapiens (human)Potency79.432811
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASEHomo sapiens (human)Potency22.387211
Chain A, Putative fructose-1,6-bisphosphate aldolaseGiardia intestinalisPotency17.740711
Chain A, TYROSYL-DNA PHOSPHODIESTERASEHomo sapiens (human)Potency19.956013
Chain B, HADH2 proteinHomo sapiens (human)Potency17.802022
cytochrome P450 3A4 isoform 1Homo sapiens (human)Potency14.219124
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_aHomo sapiens (human)Potency34.492513
DNA dC->dU-editing enzyme APOBEC-3F isoform aHomo sapiens (human)Potency22.387211
DNA dC->dU-editing enzyme APOBEC-3G isoform 1Homo sapiens (human)Potency27.245423
DNA polymerase betaHomo sapiens (human)Potency44.668411
DNA polymerase iota isoform a (long)Homo sapiens (human)Potency62.303212
DNA polymerase kappa isoform 1Homo sapiens (human)Potency47.494713
estrogen nuclear receptor alphaHomo sapiens (human)Potency42.9745814
estrogen receptor 2 (ER beta)Homo sapiens (human)Potency27.472722
estrogen-related nuclear receptor alphaHomo sapiens (human)Potency17.661666
euchromatic histone-lysine N-methyltransferase 2Homo sapiens (human)Potency12.589311
farnesoid X nuclear receptorHomo sapiens (human)Potency46.979244
flap endonuclease 1Homo sapiens (human)Potency60.456612
GABA theta subunitRattus norvegicus (Norway rat)Potency14.219112
Gamma-aminobutyric acid receptor subunit alpha-1Rattus norvegicus (Norway rat)Potency14.219112
Gamma-aminobutyric acid receptor subunit alpha-2Rattus norvegicus (Norway rat)Potency14.219112
Gamma-aminobutyric acid receptor subunit alpha-3Rattus norvegicus (Norway rat)Potency14.219112
Gamma-aminobutyric acid receptor subunit alpha-4Rattus norvegicus (Norway rat)Potency14.219112
Gamma-aminobutyric acid receptor subunit alpha-5Rattus norvegicus (Norway rat)Potency14.219112
Gamma-aminobutyric acid receptor subunit alpha-6Rattus norvegicus (Norway rat)Potency14.219112
Gamma-aminobutyric acid receptor subunit beta-1Rattus norvegicus (Norway rat)Potency14.219112
Gamma-aminobutyric acid receptor subunit beta-2Rattus norvegicus (Norway rat)Potency14.219112
Gamma-aminobutyric acid receptor subunit beta-3Rattus norvegicus (Norway rat)Potency14.219112
Gamma-aminobutyric acid receptor subunit deltaRattus norvegicus (Norway rat)Potency14.219112
Gamma-aminobutyric acid receptor subunit epsilonRattus norvegicus (Norway rat)Potency14.219112
Gamma-aminobutyric acid receptor subunit gamma-1Rattus norvegicus (Norway rat)Potency14.219112
Gamma-aminobutyric acid receptor subunit gamma-2Rattus norvegicus (Norway rat)Potency14.219112
Gamma-aminobutyric acid receptor subunit gamma-3Rattus norvegicus (Norway rat)Potency14.219112
Gamma-aminobutyric acid receptor subunit piRattus norvegicus (Norway rat)Potency14.219112
gemininHomo sapiens (human)Potency14.783024
GLI family zinc finger 3Homo sapiens (human)Potency14.703333
GLS proteinHomo sapiens (human)Potency28.183811
glucocerebrosidaseHomo sapiens (human)Potency32.464812
glucocorticoid receptor [Homo sapiens]Homo sapiens (human)Potency43.294334
Glutamate receptor 2Rattus norvegicus (Norway rat)Potency77.428611
GTP-binding nuclear protein Ran isoform 1Homo sapiens (human)Potency35.481311
Guanine nucleotide-binding protein GHomo sapiens (human)Potency35.481311
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)Homo sapiens (human)Potency17.782811
heat shock protein beta-1Homo sapiens (human)Potency27.316222
hemoglobin subunit betaHomo sapiens (human)Potency39.810711
Histamine H2 receptorCavia porcellus (domestic guinea pig)Potency7.943314
histone acetyltransferase KAT2A isoform 1Homo sapiens (human)Potency39.810711
Histone H2A.xCricetulus griseus (Chinese hamster)Potency101.391011
histone-lysine N-methyltransferase 2A isoform 2 precursorHomo sapiens (human)Potency14.125411
huntingtin isoform 2Homo sapiens (human)Potency3.548111
hypoxia-inducible factor 1 alpha subunitHomo sapiens (human)Potency52.297022
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)Homo sapiens (human)Potency6.309622
IDH1Homo sapiens (human)Potency16.360111
importin subunit beta-1 isoform 1Homo sapiens (human)Potency25.665122
Integrin alpha-IIbHomo sapiens (human)Potency39.810711
Integrin beta-3Homo sapiens (human)Potency39.810711
interleukin 8Homo sapiens (human)Potency84.126711
lamin isoform A-delta10Homo sapiens (human)Potency18.629812
lethal factor (plasmid)Bacillus anthracis str. A2012Potency0.079411
LuciferasePhotinus pyralis (common eastern firefly)Potency27.323433
lysosomal alpha-glucosidase preproproteinHomo sapiens (human)Potency39.506811
Microtubule-associated protein tauHomo sapiens (human)Potency3.548112
mitogen-activated protein kinase 1Homo sapiens (human)Potency35.716812
muscleblind-like protein 1 isoform 1Homo sapiens (human)Potency39.810711
neuropeptide S receptor isoform AHomo sapiens (human)Potency0.316211
Nrf2Homo sapiens (human)Potency22.387211
nuclear factor erythroid 2-related factor 2 isoform 1Homo sapiens (human)Potency21.640744
nuclear factor NF-kappa-B p105 subunit isoform 1Homo sapiens (human)Potency50.118711
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_aHomo sapiens (human)Potency3.489511
Nuclear receptor ROR-gammaHomo sapiens (human)Potency33.491511
nuclear receptor ROR-gamma isoform 1Mus musculus (house mouse)Potency19.6816210
nuclear receptor subfamily 1, group I, member 3Homo sapiens (human)Potency62.353133
ParkinHomo sapiens (human)Potency22.387211
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1Homo sapiens (human)Potency19.952611
peripheral myelin protein 22Rattus norvegicus (Norway rat)Potency20.314811
peroxisome proliferator activated receptor gammaHomo sapiens (human)Potency27.096258
peroxisome proliferator-activated receptor deltaHomo sapiens (human)Potency29.504755
phosphopantetheinyl transferaseBacillus subtilisPotency38.892213
PINK1Homo sapiens (human)Potency22.387211
plasminogen precursorMus musculus (house mouse)Potency3.981111
polyunsaturated fatty acid lipoxygenase ALOX12Homo sapiens (human)Potency19.952611
Polyunsaturated fatty acid lipoxygenase ALOX15BHomo sapiens (human)Potency7.943312
potassium voltage-gated channel subfamily H member 2 isoform dHomo sapiens (human)Potency3.814612
pregnane X nuclear receptorHomo sapiens (human)Potency37.301922
pregnane X receptorRattus norvegicus (Norway rat)Potency79.432811
progesterone receptorHomo sapiens (human)Potency39.839622
pyruvate kinase PKM isoform aHomo sapiens (human)Potency28.183822
RAR-related orphan receptor gammaMus musculus (house mouse)Potency53.812622
retinoic acid nuclear receptor alpha variant 1Homo sapiens (human)Potency9.217622
retinoid X nuclear receptor alphaHomo sapiens (human)Potency30.773544
SMAD family member 2Homo sapiens (human)Potency41.541022
SMAD family member 3Homo sapiens (human)Potency41.541022
Smad3Homo sapiens (human)Potency28.934212
snurportin-1Homo sapiens (human)Potency25.665122
TAR DNA-binding protein 43Homo sapiens (human)Potency35.481311
TDP1 proteinHomo sapiens (human)Potency15.9634210
thioredoxin glutathione reductaseSchistosoma mansoniPotency39.810711
thioredoxin reductaseRattus norvegicus (Norway rat)Potency50.118711
thyroid hormone receptor beta isoform 2Rattus norvegicus (Norway rat)Potency26.291026
thyroid hormone receptor beta isoform aHomo sapiens (human)Potency52.131533
thyroid stimulating hormone receptorHomo sapiens (human)Potency25.460755
thyrotropin-releasing hormone receptorHomo sapiens (human)Potency27.724711
transcriptional regulator ERG isoform 3Homo sapiens (human)Potency15.848911
tumor susceptibility gene 101 proteinHomo sapiens (human)Potency19.952611
urokinase plasminogen activator surface receptor precursorMus musculus (house mouse)Potency3.981111
urokinase-type plasminogen activator precursorMus musculus (house mouse)Potency3.981111
USP1 protein, partialHomo sapiens (human)Potency7.550622
v-jun sarcoma virus 17 oncogene homolog (avian)Homo sapiens (human)Potency13.984022
vitamin D (1,25- dihydroxyvitamin D3) receptorHomo sapiens (human)Potency39.596955
vitamin D3 receptor isoform VDRAHomo sapiens (human)Potency23.453612
Voltage-dependent calcium channel gamma-2 subunitMus musculus (house mouse)Potency77.428611

Inhibition Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform aHomo sapiens (human)IC509.699522
10 kDa chaperonin Escherichia coliIC503.000022
10 kDa heat shock protein, mitochondrialHomo sapiens (human)IC508.300011
17-beta-hydroxysteroid dehydrogenase type 2Homo sapiens (human)IC501.730011
60 kDa chaperoninEscherichia coli K-12IC50250.000011
60 kDa chaperonin Escherichia coliIC503.000022
60 kDa heat shock protein, mitochondrialHomo sapiens (human)IC508.300011
AcetylcholinesteraseElectrophorus electricus (electric eel)IC50132.130022
AcetylcholinesteraseHomo sapiens (human)IC505.000011
alkaline phosphatase, germ cell type preproproteinHomo sapiens (human)IC50100.000011
alkaline phosphatase, intestinalHomo sapiens (human)IC50100.000011
alkaline phosphatase, tissue-nonspecific isozyme isoform 1 preproproteinHomo sapiens (human)IC50100.000011
Alpha-1A adrenergic receptorRattus norvegicus (Norway rat)IC505.400011
Alpha-1B adrenergic receptorRattus norvegicus (Norway rat)IC505.400011
Alpha-1D adrenergic receptorRattus norvegicus (Norway rat)IC505.400011
Alpha-synucleinHomo sapiens (human)IC5081.010022
Amine oxidase [flavin-containing] AHomo sapiens (human)IC503.500033
Amine oxidase [flavin-containing] AHomo sapiens (human)Ki0.710011
Amine oxidase [flavin-containing] BHomo sapiens (human)IC502.573333
Amine oxidase [flavin-containing] BHomo sapiens (human)Ki21.500011
Aminopeptidase NHomo sapiens (human)IC5015.500011
Aminopeptidase NSus scrofa (pig)IC5015.500011
Amyloid-beta precursor proteinHomo sapiens (human)IC509.85413030
Beta lactamase (plasmid)Pseudomonas aeruginosaIC507.751011
Beta-secretase 1Homo sapiens (human)IC50343.000011
Broad substrate specificity ATP-binding cassette transporter ABCG2Homo sapiens (human)IC501.630011
CDGSH iron-sulfur domain-containing protein 1Homo sapiens (human)IC502.360011
CDGSH iron-sulfur domain-containing protein 1Homo sapiens (human)Ki0.101011
CholinesteraseEquus caballus (horse)IC50300.000011
CholinesteraseHomo sapiens (human)IC505.000011
CREB-binding proteinHomo sapiens (human)IC5025.000044
Cysteine protease Trypanosoma brucei rhodesienseIC507.750011
D-amino-acid oxidaseSus scrofa (pig)IC501.070022
Glutathione S-transferase PHomo sapiens (human)IC5069.000011
Glycogen synthase kinase-3 betaHomo sapiens (human)IC5017.950011
Glycogen synthase kinase-3 betaRattus norvegicus (Norway rat)IC500.066011
GTPase KRasHomo sapiens (human)IC503.580011
Heme oxygenase 1 Rattus norvegicus (Norway rat)IC5010.000011
Heme oxygenase 2Rattus norvegicus (Norway rat)IC5010.000011
Histone acetyltransferase p300Homo sapiens (human)IC5021.916766
Histone deacetylase 1Homo sapiens (human)IC50187.000011
Histone deacetylase 1Homo sapiens (human)Ki50.790011
Histone deacetylase 11 Homo sapiens (human)IC50187.000011
Histone deacetylase 2Homo sapiens (human)IC50187.000011
Histone deacetylase 2Homo sapiens (human)Ki97.670011
Histone deacetylase 3Homo sapiens (human)IC50187.000011
Histone deacetylase 4Homo sapiens (human)IC50187.000011
Histone deacetylase 5Homo sapiens (human)IC50187.000011
Histone deacetylase 6Homo sapiens (human)IC50187.000011
Histone deacetylase 7Homo sapiens (human)IC50187.000011
Histone deacetylase 8Homo sapiens (human)IC50187.000011
Histone deacetylase 8Homo sapiens (human)Ki64.980011
Histone deacetylase 9Homo sapiens (human)IC50187.000011
hypothetical protein SA1422Staphylococcus aureus subsp. aureus N315IC5042.900022
intestinal alkaline phosphatase precursorMus musculus (house mouse)IC5018.700011
Lactoylglutathione lyaseHomo sapiens (human)Ki0.005011
Lysine-specific histone demethylase 1AHomo sapiens (human)IC509.600011
Microtubule-associated protein tauHomo sapiens (human)IC5054.875044
NACHT, LRR and PYD domains-containing protein 3 Homo sapiens (human)IC5024.200011
Neuronal proto-oncogene tyrosine-protein kinase Src Mus musculus (house mouse)IC502.200011
perilipin-1Homo sapiens (human)IC509.167011
perilipin-5Homo sapiens (human)IC5010.232011
Phospholipase A2Homo sapiens (human)IC5011.100011
Polyamine deacetylase HDAC10Homo sapiens (human)IC50187.000011
Polyunsaturated fatty acid 5-lipoxygenaseHomo sapiens (human)IC5030.000011
Prostaglandin E synthaseHomo sapiens (human)IC501.800033
Prostaglandin G/H synthase 1Ovis aries (sheep)IC5063.835012
Prostaglandin G/H synthase 2Homo sapiens (human)IC5063.835012
Proteasome subunit beta type-5Homo sapiens (human)IC5010.000022
Protein farnesyltransferase subunit betaHomo sapiens (human)IC5011.900011
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alphaHomo sapiens (human)IC5011.900011
Replicase polyprotein 1abSevere acute respiratory syndrome coronavirus 2IC5031.750012
Replicase polyprotein 1abSevere acute respiratory syndrome-related coronavirusIC5031.750012
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1Oryctolagus cuniculus (rabbit)IC503.000011
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1Oryctolagus cuniculus (rabbit)Ki5.800011
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2Homo sapiens (human)IC507.000011
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2Homo sapiens (human)Ki53.000011
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 Rattus norvegicus (Norway rat)Ki5.800011
Sarcoplasmic/endoplasmic reticulum calcium ATPase 3Homo sapiens (human)IC507.000011
Sarcoplasmic/endoplasmic reticulum calcium ATPase 3Homo sapiens (human)Ki8.600011
Serine/threonine-protein kinase PAK 1Homo sapiens (human)IC5016.000011
Sortase AStreptococcus mutansIC5010.200011
Thioredoxin reductase 1, cytoplasmicHomo sapiens (human)IC5040.466733
Thioredoxin reductase 1, cytoplasmicRattus norvegicus (Norway rat)IC500.810033
Thioredoxin reductase 2, mitochondrialHomo sapiens (human)IC5040.466733
Thioredoxin reductase 3Homo sapiens (human)IC5040.466733
Thiosulfate sulfurtransferaseHomo sapiens (human)IC5056.000011
Tissue factorHomo sapiens (human)IC500.013211
toll-like receptor 9Homo sapiens (human)IC508.362011
TPA: protein transporter TIM10Saccharomyces cerevisiae S288CIC5019.700011
TyrosinaseHomo sapiens (human)IC505.000011
Voltage-dependent L-type calcium channel subunit alpha-1CRattus norvegicus (Norway rat)IC50100.000011
Voltage-dependent L-type calcium channel subunit alpha-1DRattus norvegicus (Norway rat)IC50100.000011
Voltage-dependent L-type calcium channel subunit alpha-1SRattus norvegicus (Norway rat)IC50100.000011

Activation Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
5-hydroxytryptamine receptor 4Homo sapiens (human)EC5010.000011
Alpha-synucleinHomo sapiens (human)Kd3.500044
Lymphocyte antigen 96Homo sapiens (human)Kd379.000011
Nuclear factor erythroid 2-related factor 2Homo sapiens (human)EC5021.000011
Replicase polyprotein 1abSevere acute respiratory syndrome coronavirus 2EC5010.000011
Replicase polyprotein 1abSevere acute respiratory syndrome-related coronavirusEC5010.000011
Sodium/bile acid cotransporterHomo sapiens (human)Kd64.300011

Other Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
Amyloid-beta precursor proteinHomo sapiens (human)DC500.755022
EWS/FLI fusion proteinHomo sapiens (human)AbsAC35_uM40.250011
Microtubule-associated protein tauHomo sapiens (human)DC50200.000011