Adult Refsum Disease

An autosomal recessive familial disorder that usually presents in childhood with POLYNEUROPATHY; SENSORINEURAL HEARING LOSS; ICHTHYOSIS; ATAXIA; RETINITIS PIGMENTOSA; and CARDIOMYOPATHIES. (From Joynt, Clinical Neurology, 1991, Ch37, p58-9; Rev Med Interne 1996;17(5):391-8) This condition can be caused by mutation in the genes encoding peroxisomal phytanoyl-CoA hydroxylase or proteins associated peroxisomal membrane, leading to impaired catabolism of PHYTANIC ACID in PEROXISOMES.

Synonym
Hereditary Motor And Sensory Neuropathy IV
Refsum Disease, Phytanic Acid Oxidase Deficiency
Refsum Disease, Phytanoyl-CoA Hydroxylase Deficiency
Adult Refsum Disease
Phytanic Acid Storage Disease
Hereditary Type IV Motor and Sensory Neuropathy
Hereditary Motor and Sensory Neuropathy, Type IV
HMSN IV
Refsum Disease
HMSN Type IV
Hereditary Motor and Sensory Neuropathy Type IV
Refsum's Syndrome
Refsum Disease, Adult
HMSN 4
Hemeralopia Heredoataxia Polyneuritiformis
Neuropathy, Hereditary Motor and Sensory, Type IV
Classic Refsum Disease
Heredopathia Atactica Polyneuritiformis
Refsum's Disease
Refsum-Thiebaut Syndrome
Refsum Disease, Classic
Refsum Syndrome
Phytanic Acid Oxidase Deficiency

Excerpt	Reference
"Refsum's disease is a rare inherited disease of lipid metabolism."	( Wall, WJ; Worthington, BS, 1979)
"Heredopathia atactica polyneuritiformis is a clinical-genetic-biochemical entity."	( Refsum, S, 1977)
"Refsum's disease (heredopathia atactica polyneuritiformis) is an autosomal recessive retinitis pigmentosa syndrome caused by the excessive deposition of phytanic acid in ocular tissues."	( Bernstein, PS; Bok, D; Lloyd, MB; O'Day, WT, 1992)
"Refsum's disease (Heredopathia atactica polyneuritiformis) is caused by accumulation of phytanic acid in all body tissues due to an inherited failure of alpha-oxidation of branched chain fatty acids."	( Blau, N; Burger, J; Gmür, J; Leppert, D; Schanz, U; Waespe, W, 1991)
"Seven patients with Heredopathia Atactica Polyneuritiformis are described."	( Billimoria, JD; Clemens, ME; Evans, R; Gibberd, FB; Goldman, JM; Retsas, S; Sherratt, RM; Whitelaw, MN, 1985)
"Infantile Refsum's disease is characterized by high levels of phytanic acid and the absence of normal hepatic peroxisomes."	( Roels, F; Vamecq, J; Van den Branden, C; Wybo, I, 1986)
"Refsum's disease is a metabolic disorder based on an inborn enzyme defect, inherited by autosomal recessive transmission."	( Feldmann, H, 1981)
"Heredopathia atactica polyneuritiformis is a biochemically defined disease with a specific dietary treatment."	( Djupesland, G; Flottorp, G; Refsum, S, 1983)
"An atypical case of Refsum disease is reported together with the peripheral nerve morphological data."	( Bonavita, V; Camarda, R; Galatioto, S; Savettieri, G, 1982)
"Refsum's disease is characterized by progressive neurological dysfunction and accumulation of phytanic acid, an isoprenoid fatty acid, in fat-containing tissues."	( Gibberd, FB; Hardman, TC; Lumb, P; Morrish, Z; Patel, F; Sankaralingam, A; Sidey, MC; Wierzbicki, AS, 1998)
"Refsum's disease is a neurological syndrome characterized by adult-onset retinitis pigmentosa, anosmia, sensory neuropathy and phytanic acidaemia."	( Chien, W; Clifton, IJ; Kershaw, NJ; Lloyd, MD; Mukherji, M; Schofield, CJ; Wierzbicki, AS, 2001)
"Adult Refsum disease is an inherited disorder in which phytanic acid accumulates in tissues and serum."	( Johnson, AW; Muller, DP; Young, SP, 2001)
"Refsum's disease (Heredopathia atactica polyneuritiformis) is an autosomal recessive disease caused by a defective alpha oxidation of a C20 fatty acid: the phytanic acid."	( Defontaines, B; Degos, CF; Jung, P; Marcaud, V, 2002)
"Refsum's disease is characterized by defective peroxisomal alpha oxidation of phytanic acid, with clinical features that include retinitis pigmentosa, polyneuropathy, anosmia and hearing loss."	( Bamiou, DE; Gibberd, FB; Luxon, LM; Sidey, MC; Spraggs, PR, 2003)
"Refsum's disease is a complex and difficult to diagnose storage disease caused by complex autosomal recessive peroxisomal disorder in which mutations of phytanolyl/pristanoyl-CoA-hydroxilase are the main cause."	( Gäckler, D; Kingreen, H; Klingel, R; Muselmann, L; Straube, R; Thiele, A, 2003)
"Refsum disease is a peroxisomal disorder characterized by adult-onset retinitis pigmentosa, anosmia, sensory neuropathy, ataxia, and an accumulation of phytanic acid in plasma and tissues."	( Asselberghs, S; Casteels, M; Foulon, V; Geens, W; Mannaerts, GP; Van Veldhoven, PP, 2003)
"Adult Refsum disease is one of the few forms of tapetoretinal degenerations accessible for therapy."	( Rüther, K, 2005)
"Refsum's disease is a rare autosomal recessive disorder with clinical features including retinitis pigmentosa, anosmia, deafness, chronic sensory-motor neuropathy, ataxia and the accumulation of phytanic acid in blood plasma and body tissues."	( Bonneau, D; Dubas, F; Levade, T; Maugin, D; Nicolas, G; Pautot, V; Prundean, A; Verny, C, 2006)
"Refsum disease is caused by a deficiency of phytanoyl-CoA hydroxylase (PHYH), the first enzyme of the peroxisomal alpha-oxidation system, resulting in the accumulation of the branched-chain fatty acid phytanic acid."	( Brites, P; Ferdinandusse, S; Hamers, FP; Komen, JC; Poll-The, BT; Thanos, M; van den Brink, CE; van der Saag, PT; Wanders, RJ; Zomer, AW, 2008)
"Refsum disease is a genetic progressive neurological disorder caused by neurotoxic phytanic acid, a nutritional component patients are unable to metabolize."	( Altenburg, C; Kemper, MJ; Kohlschütter, A; Lukacs, Z; Rüther, K; Santer, R, 2012)
"Refsum's disease is a rare autosomal recessive disorder of fatty acid metabolism."	( Bunia, J; Heibges, A; Kalb, K; Klingel, R; Wagner, S; Zolotov, D, 2012)
"Refsum disease is an autosomal recessive disorder of peroxisomal metabolism biochemically characterized by highly elevated concentrations of phytanic acid (Phyt) in a variety of tissues including the cerebellum."	( Busanello, EN; Leipnitz, G; Ribeiro, CA; Tonin, AM; Vargas, CR; Viegas, CM; Wajner, M; Zanatta, Â, 2013)
"Refsum disease is an inherited peroxisomal disorder caused by severe deficiency of phytanoyl-CoA hydroxylase activity."	( Amaral, AU; Bender, JG; Marschner, RA; Ribeiro, RT; Roginski, AC; Wajner, M; Wajner, SM; Zemniaçak, ÂB, 2023)

Excerpt	Reference
"Infantile Refsum disease has clinical features and a pathophysiology distinct from classic Refsum disease, despite occasionally presenting for examination later in life."	( Maberley, DA; Pakzad-Vaezi, KL, 2014)
"Thus, patients with Refsum's disease have to follow a specific diet resigning foods with high levels of phytanic acid and trans-phytol like products from ruminant animals with a tolerable daily intake (TDI) of ≤ 10 mg/d."	( Krauß, S; Michaelis, L; Vetter, W, 2017)

Excerpt	Reference
"A patient with severe heredopathia atactica polyneuritiformis (Refsum's disease) has responded well to treatment by large-volume plasma-exchange."	( Billimoria, JD; Gibberd, FB; Page, NG; Retsas, S, 1979)
"Five cases of heredopathia atactica polyneuritiformis (HAP--Refsum's disease) were treated by serial plasma exchanges."	( Dick, JP; Gibberd, FB; Harari, D; Sidey, MC, 1991)
"Two patients with infantile phytanic acid storage disease (infantile Refsum disease), one of whom showed the presence of morphologically normal peroxisomes in a liver biopsy, were treated with a low phytanic acid diet for more than 2 years and the effects of treatment on certain clinical, biochemical and ultrastructural parameters were examined."	( Carter, R; Jaunzems, A; Manson, J; Poulos, A; Robertson, EF; Sharp, P; Wise, G, 1988)
"Fourteen patients with heredopathia atactica polyneuritiformis had a plasma phytanic acid level before treatment of 992-6400 mumol/l."	( Billimoria, JD; Britton, TC; Clemens, ME; Gibberd, FB; Sidey, MC, 1989)
"A case of Refsum's disease treated by serial plasma exchanges together with a moderate low phytanate diet is reported."	( Bogousslavsky, J; Hungerbühler, JP; Meier, C; Quadri, P; Rousselle, L, 1985)
"Five patients with Refsum's disease were treated by plasma exchange."	( Gibberd, FB, 1993)
"Adult Refsum disease is one of the few forms of tapetoretinal degenerations accessible for therapy."	( Rüther, K, 2005)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	173 (59.04)	23.3326
1990's	55 (18.77)	12.5806
2000's	45 (15.36)	18.1394
2010's	16 (5.46)	28.8240
2020's	4 (1.37)	9.53

Drug	Relationship Strength	Studies	Trials
ammonium hydroxide	low	1	0
formic acid	low	1	0
carnitine	low	2	0
choline	low	1	0
methylmalonic acid	low	1	0
glycine	low	2	0
glycerol	low	1	0
pipecolic acid	low	8	0
phytic acid	low	5	0
inositol	low	10	0
niacin	low	1	0
orotic acid	low	2	0
palmitic acid	low	4	0
picolinic acid	low	1	0
pyridoxine	low	2	0
pyruvic acid	low	1	0
taurine	low	2	0
thiamine	low	1	0
uric acid	low	1	0
urea	low	2	0
1-anilino-8-naphthalenesulfonate	low	1	0
clofibrate	low	1	0
dimercaprol	low	1	0
erythrosine	low	1	0
flumazenil	low	3	0
fluoxetine	low	1	0
isoniazid	low	1	0
2-propanol	low	2	0
lorazepam	low	1	0
propranolol	low	1	0
risperidone	low	1	0
sebacic acid	low	1	0
stearic acid	low	1	0
thalidomide	low	1	0
prednisolone	low	1	0
thymidine	low	1	0
penicillamine	low	1	0
alanine	low	1	0
aspartic acid	low	1	0
sucrose	low	1	0
tyrosine	low	1	0
leucine	low	1	0
methionine	low	1	0
histidine	low	2	0
tryptophan	low	1	0
arginine	low	1	0
tromethamine	low	1	0
rotenone	low	1	0
methyl palmitate	low	1	0
behenic acid	low	1	0
4-hydroxyphenyllactic acid	low	1	0
fluorobenzenes	low	1	0
suberic acid	low	1	0
hexacosanoic acid	low	5	0
lignoceric acid	low	3	0
3-methyladipic acid	medium	5	1
d-alpha tocopherol	low	3	0
fucose	low	1	0
deuterium	low	2	0
ozone	low	1	0
phytanic acid	medium	163	1
tetradecanoylphorbol acetate	low	1	0
phenyl acetate	low	4	0
s-adenosylmethionine	low	2	0
ng-nitroarginine methyl ester	low	1	0
6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid	low	1	0
cholesteryl sulfate	low	1	0
pentafluorobenzyl bromide	low	1	0
coenzyme a	low	5	0
2-hydroxyisovaleric acid	low	1	0
3,7,11,15-tetramethyl-1-hexadecanol	low	1	0
valerates	low	2	0
caprylates	low	2	0
3,7,12-trihydroxycoprostanic acid	low	1	0
3,7,12-trihydroxycholestan-26-oic acid	low	1	0
pristanic acid	low	17	0
phytol	low	16	0
proline	low	1	0
biotin	low	1	0
3-methylheptadecanoic acid	low	1	0
2-hydroxyphytanic acid	low	2	0
2,6-dimethyloctane-1,8-dioic acid	low	1	0
cholic acid	low	1	0
mevalonic acid	low	4	0
inositol 1,4,5-trisphosphate	low	1	0
phytanoyl-coenzyme a	low	3	0
acetyl coenzyme a	low	1	0
tretinoin	low	2	0
arachidonic acid	low	1	0
retinol	low	1	0
oleic acid	low	2	0
tacrolimus	low	1	0
bromochloroacetic acid	low	3	0
isomethyleugenol	low	3	0
D-fructopyranose	low	1	0
nadp	low	5	0
lithium	low	1	0
cytellin	low	1	0
dinoprostone	low	1	0
linoleic acid	low	1	0
leukotriene b4	low	1	0
leukotriene e4	low	1	0
erucic acid	low	1	0
thallium	low	1	0
cysteine	low	1	0
phosphorus	low	1	0
antimycin a	low	1	0
i(3)so3-galactosylceramide	low	1	0
cholanic acid	low	1	0
u 18666a	low	1	0
g(m1) ganglioside	low	1	0
gw9508	low	1	0
phytenic acid	low	3	0
acid phosphatase	low	1	0
pristanal	low	1	0
nad	low	2	0
phosphatidylcholines	low	5	0
chlorophyll a	low	2	0
ganglioside, gd1a	low	1	0
glycolipids	low	10	0
ascorbic acid	low	1	0
g(m3) ganglioside	low	1	0
aconitine	low	1	0
digitonin	low	2	0
eye	low	2	0

Protein Targets (880)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain B, pheromone binding protein	0	0	1	1
Chain A, pheromone binding protein	0	0	1	1
Chain A, JmjC domain-containing histone demethylation protein 3A	8	0	0	8
Chain A, RNA-directed RNA polymerase NS5	0	1	0	1
acid sphingomyelinase	1	0	0	1
thioredoxin reductase	13	0	0	13
USP1 protein, partial	10	0	0	10
TDP1 protein	19	0	0	19
vitamin D3 receptor isoform VDRA	13	0	0	13
importin subunit beta-1 isoform 1	3	0	0	3
flap endonuclease 1	7	0	0	7
serine/threonine-protein kinase PLK1	2	0	0	2
snurportin-1	3	0	0	3
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	2	0	0	2
GTP-binding nuclear protein Ran isoform 1	3	0	0	3
DNA polymerase eta isoform 1	1	0	0	1
DNA polymerase iota isoform a (long)	8	0	0	8
urokinase-type plasminogen activator precursor	1	0	0	1
plasminogen precursor	1	0	0	1
urokinase plasminogen activator surface receptor precursor	1	0	0	1
geminin	19	0	0	19
DNA polymerase kappa isoform 1	13	0	0	13
fibroblast growth factor 22 isoform 1 precursor	0	0	0	1
Mitogen-activated protein kinase 13	0	1	0	1
Beta-lactamase	0	1	0	1
Transthyretin	0	0	1	1
Fatty acid-binding protein, intestinal	0	2	1	3
Fatty acid-binding protein, adipocyte	0	8	4	12
Cyclin-A2	0	1	0	1
Cannabinoid receptor 1	0	0	1	1
Cyclin-dependent kinase 2	0	1	1	2
Choline O-acetyltransferase	0	2	0	2
Mitogen-activated protein kinase 12	0	1	0	1
Guanine nucleotide-binding protein G	2	0	0	2
Fatty acid-binding protein 5	0	5	2	7
Fatty acid-binding protein 5	0	0	2	2
Mitogen-activated protein kinase 11	0	1	0	1
Mitogen-activated protein kinase 14	0	1	0	1
Solute carrier family 22 member 20	0	5	0	5
Solute carrier family 22 member 6	0	5	0	5
hypoxia-inducible factor 1 alpha subunit	7	0	0	7
RAR-related orphan receptor gamma	21	0	0	21
GLI family zinc finger 3	22	0	0	22
AR protein	30	0	0	30
aldehyde dehydrogenase 1 family, member A1	19	0	0	19
retinoic acid nuclear receptor alpha variant 1	25	0	0	25
retinoid X nuclear receptor alpha	13	0	0	13
estrogen nuclear receptor alpha	36	0	0	36
peroxisome proliferator-activated receptor delta	12	0	0	12
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	11	0	0	11
activating transcription factor 6	11	0	0	11
v-jun sarcoma virus 17 oncogene homolog (avian)	11	0	0	11
Histone H2A.x	7	0	0	7
thyroid hormone receptor beta isoform a	8	0	0	8
heat shock protein beta-1	8	0	0	8
nuclear factor erythroid 2-related factor 2 isoform 1	19	0	0	19
lamin isoform A-delta10	19	0	0	19
Voltage-dependent calcium channel gamma-2 subunit	7	0	0	7
Glutamate receptor 2	7	0	0	7
Chain A, Beta-lactamase	7	0	0	7
GLS protein	7	0	0	7
euchromatic histone-lysine N-methyltransferase 2	24	0	0	24
Polyphenol oxidase 2	0	4	0	5
Acetylcholinesterase	0	3	0	3
Prostaglandin G/H synthase 1	0	3	0	3
Sodium-dependent dopamine transporter	0	4	0	4
Prostaglandin G/H synthase 2	0	2	1	4
Xanthine dehydrogenase/oxidase	0	2	0	2
Dehydrogenase/reductase SDR family member 9	0	1	0	1
N-alpha-acetyltransferase 50	0	0	2	2
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	19	0	0	19
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	11	0	0	11
Carbonic anhydrase 1	0	1	0	7
Carbonic anhydrase 2	0	2	1	9
Alanine racemase, biosynthetic	0	0	0	1
5-hydroxytryptamine receptor 1D	0	0	0	3
Glutamate receptor ionotropic, NMDA 1	0	5	2	10
Proton-coupled amino acid transporter 1	0	6	0	7
Adenosine deaminase	0	0	0	1
Carbonic anhydrase 4	0	0	0	3
Chain A, ADIPOCYTE LIPID-BINDING PROTEIN	0	0	1	1
Chain A, SERUM ALBUMIN	0	0	2	2
Chain A, SERUM ALBUMIN	0	0	2	2
Chain A, HADH2 protein	6	0	0	6
Chain B, HADH2 protein	6	0	0	6
Chain A, 2-oxoglutarate Oxygenase	6	0	0	6
Chain A, ATP-DEPENDENT DNA HELICASE Q1	4	0	0	4
Chain A, Cruzipain	7	0	0	7
15-lipoxygenase, partial	5	0	0	5
phosphopantetheinyl transferase	13	0	0	13
Microtubule-associated protein tau	10	0	0	10
thioredoxin glutathione reductase	5	0	0	5
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	2	0	0	2
Bloom syndrome protein isoform 1	12	0	0	12
cellular tumor antigen p53 isoform a	2	0	0	2
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	4	0	0	4
ubiquitin carboxyl-terminal hydrolase 2 isoform a	3	0	0	3
nuclear receptor ROR-gamma isoform 1	10	0	0	10
lethal(3)malignant brain tumor-like protein 1 isoform I	4	0	0	4
cytochrome P450 3A4 isoform 1	9	0	0	9
histone acetyltransferase KAT2A isoform 1	10	0	0	10
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	1	0	0	1
caspase-1 isoform alpha precursor	1	0	0	1
Fatty-acid amide hydrolase 1	0	2	0	2
Gamma-aminobutyric acid receptor subunit pi	9	3	1	13
Polyunsaturated fatty acid lipoxygenase ALOX15B	2	0	0	2
Prostaglandin G/H synthase 1	0	4	0	5
Trypsin	0	3	0	3
Coagulation factor VII	0	3	0	3
60 kDa chaperonin	0	2	0	2
60 kDa heat shock protein, mitochondrial	0	2	0	2
Aromatase	0	3	0	3
Tissue factor	0	3	0	3
Gamma-aminobutyric acid receptor subunit beta-1	9	3	1	13
Gamma-aminobutyric acid receptor subunit delta	9	3	1	13
Gamma-aminobutyric acid receptor subunit gamma-2	9	3	1	13
Gamma-aminobutyric acid receptor subunit alpha-5	9	3	1	13
Gamma-aminobutyric acid receptor subunit alpha-3	9	3	1	13
Gamma-aminobutyric acid receptor subunit gamma-1	9	3	1	13
Gamma-aminobutyric acid receptor subunit alpha-2	9	3	1	13
Gamma-aminobutyric acid receptor subunit alpha-4	9	3	1	13
Gamma-aminobutyric acid receptor subunit gamma-3	9	3	1	13
Gamma-aminobutyric acid receptor subunit alpha-6	9	3	1	13
Nuclear receptor subfamily 4 group A member 2	0	0	3	3
Histamine H2 receptor	3	0	0	3
10 kDa heat shock protein, mitochondrial	0	2	0	2
Calmodulin	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	9	3	1	13
Gamma-aminobutyric acid receptor subunit beta-3	9	3	1	13
Gamma-aminobutyric acid receptor subunit beta-2	9	3	1	13
Disintegrin and metalloproteinase domain-containing protein 17	2	0	0	2
Prostaglandin G/H synthase 2	0	5	0	6
Solute carrier organic anion transporter family member 2A1	0	0	0	2
Thiosulfate sulfurtransferase	0	2	0	2
Lanosterol 14-alpha demethylase	0	1	0	1
60 kDa chaperonin	0	2	0	2
10 kDa chaperonin	0	2	0	2
GABA theta subunit	9	3	1	13
Gamma-aminobutyric acid receptor subunit epsilon	9	3	1	13
Solute carrier organic anion transporter family member 1B3	0	2	0	2
Cytosolic phospholipase A2 gamma	0	1	0	1
Transient receptor potential cation channel subfamily V member 2	0	4	0	4
Solute carrier organic anion transporter family member 1B1	0	3	0	3
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	3	3
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	3	3
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	3	3
NFKB1 protein, partial	1	0	0	1
thyroid stimulating hormone receptor	11	0	0	11
alpha-galactosidase	1	0	0	1
cytochrome P450 2C19 precursor	6	0	0	6
chromobox protein homolog 1	8	0	0	8
muscarinic acetylcholine receptor M1	5	0	0	5
lethal factor (plasmid)	8	0	0	8
Cytochrome P450 3A4	0	6	2	9
Nitric oxide synthase, endothelial	0	1	0	3
Nitric oxide synthase, brain	0	1	0	2
Nitric oxide synthase, brain	0	0	0	1
Nitric oxide synthase, inducible	0	1	0	2
Nitric oxide synthase, inducible	0	1	1	4
Cationic amino acid transporter 3	0	1	0	1
ATP-dependent phosphofructokinase	9	0	0	9
Chain A, Hyaluronidase, phage associated	0	1	0	1
acetylcholinesterase	6	0	0	6
cytochrome P450 family 3 subfamily A polypeptide 4	16	0	0	16
glucocorticoid receptor [Homo sapiens]	19	0	0	19
estrogen-related nuclear receptor alpha	23	0	0	23
vitamin D (1,25- dihydroxyvitamin D3) receptor	11	0	0	11
IDH1	2	0	0	2
nuclear factor erythroid 2-related factor 2 isoform 2	4	0	0	4
thyroid hormone receptor beta isoform 2	15	0	0	15
Pancreatic alpha-amylase	0	2	0	2
Albumin	0	1	0	1
Urease	0	1	0	1
Prolyl 4-hydroxylase subunit alpha-1	0	0	0	1
Tyrosinase	0	1	0	1
Alpha-2B adrenergic receptor	0	4	3	8
Spike glycoprotein	7	0	0	7
Hyaluronate lyase	0	1	0	1
Prolyl hydroxylase EGLN2	0	0	0	1
Egl nine homolog 1	0	0	0	1
Prolyl hydroxylase EGLN3	0	0	0	1
Hypoxia-inducible factor 1-alpha inhibitor	0	0	0	1
Solute carrier family 23 member 1	0	1	0	1
Chain A, Ferritin light chain	6	0	0	6
arylsulfatase A	7	0	0	7
Metabotropic glutamate receptor 6	0	0	1	1
Excitatory amino acid transporter 4	0	1	0	1
Glutamate transporter homolog	0	0	1	1
N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase	0	1	0	1
Excitatory amino acid transporter 1	0	1	0	1
Excitatory amino acid transporter 2	0	1	0	1
Excitatory amino acid transporter 3	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	3	2	8
Glutamate receptor ionotropic, NMDA 2B	0	3	2	8
Glutamate receptor ionotropic, NMDA 2C	0	3	2	8
Metabotropic glutamate receptor 1	0	0	1	1
Metabotropic glutamate receptor 2	0	0	1	1
Carbonic anhydrase-like protein, putative	0	0	0	4
Glutamate receptor ionotropic, NMDA 2D	0	3	2	8
Glutamate receptor ionotropic, NMDA 3B	0	3	2	8
Glutamate receptor ionotropic, NMDA 3A	0	3	2	8
Chain A, Avidin	0	0	1	1
Chain A, Protein (streptavidin)	0	0	1	1
Chain B, Protein (streptavidin)	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain D, Streptavidin	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain D, Streptavidin	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain D, Streptavidin	0	0	1	1
Chain A, Streptavidin Complex With Biotin	0	0	1	1
Chain D, Circularly Permuted Core-streptavidin E51/a46	0	0	1	1
Chain A, Core-streptavidin	0	0	1	1
Chain D, Core-streptavidin	0	0	1	1
Chain A, Core-streptavidin	0	0	1	1
Chain D, Core-streptavidin	0	0	1	1
Chain A, Core-streptavidin	0	0	1	1
Chain D, Core-streptavidin	0	0	1	1
Chain A, Core-streptavidin	0	0	1	1
Chain D, Core-streptavidin	0	0	1	1
Chain A, Avidin	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain B, Streptavidin	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain B, Streptavidin	0	0	1	1
apical membrane antigen 1, AMA1	1	0	0	1
nonstructural protein 1	0	1	0	1
green fluorescent protein, partial	0	1	0	1
insulin-degrading enzyme isoform 1	0	0	1	1
Streptavidin	0	0	1	1
Receptor-type tyrosine-protein phosphatase beta	0	0	0	1
nuclear receptor subfamily 1, group I, member 3	10	0	0	10
thyroid stimulating hormone receptor	10	0	0	10
Cellular tumor antigen p53	18	0	0	18
Nuclear receptor ROR-gamma	3	1	1	5
Chain A, Beta-lactoglobulin	0	0	1	1
Chain A, Beta-lactoglobulin	0	0	1	1
UDP-3-O-acyl-N-acetylglucosamine deacetylase	0	0	1	1
survival motor neuron protein isoform d	5	0	0	5
Integrin beta-3	1	0	0	1
Integrin alpha-IIb	1	0	0	1
Inositol monophosphatase 1	3	0	0	3
Hypoxia-inducible factor 1-alpha	0	1	0	1
Endothelial PAS domain-containing protein 1	0	1	0	1
Solute carrier family 22 member 5	0	0	0	1
Solute carrier family 22 member 5	0	0	0	1
Bile salt export pump	0	15	0	15
Solute carrier family 22 member 16	0	0	0	1
Solute carrier family 22 member 21	0	0	0	1
Solute carrier family 22 member 5	0	0	0	1
Cholesterol 24-hydroxylase	0	0	1	1
Ubiquitin carboxyl-terminal hydrolase 2	0	1	0	1
Phospholipase A2	0	0	1	1
Alpha-2A adrenergic receptor	0	4	3	8
Vitamin D3 receptor	0	1	1	2
Alpha-2C adrenergic receptor	0	3	3	7
G-protein coupled bile acid receptor 1	0	1	0	1
G-protein coupled bile acid receptor 1	0	1	1	2
Bile acid receptor	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Putative Glycine Betaine-binding Abc Transporter Protein	0	0	1	1
Chain A, PUTATIVE GLYCINE BETAINE-BINDING ABC TRANSPORTER PROTEIN	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Choline-binding protein	0	0	1	1
Solute carrier family 22 member 1	0	1	0	2
Solute carrier family 22 member 2	0	1	0	3
Solute carrier family 22 member 1	0	2	0	5
Solute carrier family 22 member 2	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-3	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-4	1	2	0	3
Neuronal acetylcholine receptor subunit alpha-2	0	1	0	1
Neuronal acetylcholine receptor subunit beta-2	1	2	0	3
Neuronal acetylcholine receptor subunit beta-3	0	1	0	1
Neuronal acetylcholine receptor subunit beta-4	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-5	0	1	0	1
Sodium- and chloride-dependent creatine transporter 1	0	1	0	1
Choline O-acetyltransferase	0	0	0	1
Neuronal acetylcholine receptor subunit alpha-6	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-9	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-7	0	2	0	2
Solute carrier family 22 member 1	0	2	0	3
High affinity choline transporter 1	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-10	0	1	0	1
Solute carrier family 22 member 2	0	2	0	3
Fumarate hydratase	3	0	0	3
GALC protein	2	0	0	2
regulator of G-protein signaling 4	7	0	0	7
EWS/FLI fusion protein	8	0	0	8
polyprotein	3	0	0	3
peripheral myelin protein 22 isoform 1	4	0	0	4
potassium voltage-gated channel subfamily H member 2 isoform d	7	0	0	7
M-phase phosphoprotein 8	4	0	0	4
ATP-binding cassette sub-family C member 3	0	10	0	10
Multidrug resistance-associated protein 4	0	10	0	11
5-hydroxytryptamine receptor 4	0	6	1	7
Fatty acid-binding protein, liver	0	5	1	6
Muscarinic acetylcholine receptor M1	0	0	1	1
Muscarinic acetylcholine receptor M3	0	0	1	1
Muscarinic acetylcholine receptor M4	0	0	1	1
Muscarinic acetylcholine receptor M5	0	0	1	1
Muscarinic acetylcholine receptor M2	0	0	1	1
Peroxisome proliferator-activated receptor alpha	0	0	1	1
Peroxisome proliferator-activated receptor gamma	0	1	1	2
Peroxisome proliferator-activated receptor gamma	0	0	1	1
Peroxisome proliferator-activated receptor alpha	3	1	4	8
Canalicular multispecific organic anion transporter 1	0	10	0	10
Histone acetyltransferase p300	0	1	0	1
Histone acetyltransferase KAT2B	0	1	0	1
Histone acetyltransferase KAT5	0	1	0	1
peripheral myelin protein 22	13	0	0	13
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	5	0	0	5
Rap guanine nucleotide exchange factor 3	3	0	0	3
Glutathione S-transferase P	0	1	0	1
Alpha-tocopherol transfer protein	0	0	1	1
G	6	0	0	6
cytochrome P450 2D6	5	0	0	5
peroxisome proliferator activated receptor gamma	12	0	0	12
Nuclear receptor subfamily 1 group I member 2	0	0	2	2
Interferon beta	7	0	0	7
HLA class I histocompatibility antigen, B alpha chain	6	0	0	6
Inositol hexakisphosphate kinase 1	6	0	0	6
ATPase family AAA domain-containing protein 5	4	0	0	4
Ataxin-2	7	0	0	7
cytochrome P450 2C9, partial	6	0	0	6
SMAD family member 2	5	0	0	5
SMAD family member 3	5	0	0	5
farnesoid X nuclear receptor	10	0	0	10
prostaglandin E2 receptor EP2 subtype	1	0	0	1
mitogen-activated protein kinase 1	2	0	0	2
Solute carrier organic anion transporter family member 1A5	0	0	0	1
Prostaglandin E2 receptor EP3 subtype	0	1	0	1
Prostaglandin E2 receptor EP4 subtype	0	1	0	1
Prostaglandin E2 receptor EP1 subtype	0	3	1	4
Prostaglandin E2 receptor EP1 subtype	0	1	0	1
Prostaglandin E2 receptor EP4 subtype	0	3	1	4
Prostaglandin F2-alpha receptor	0	0	1	1
Prostaglandin E2 receptor EP4 subtype	0	1	1	2
Prostaglandin E2 receptor EP3 subtype	0	3	1	4
Prostaglandin E2 receptor EP2 subtype	0	2	1	3
Prostacyclin receptor	0	2	1	3
Solute carrier family 22 member 6	0	0	0	2
Solute carrier family 22 member 7	0	0	0	1
Prostaglandin E2 receptor EP2 subtype	0	1	0	1
Prostaglandin E2 receptor EP2 subtype	0	1	1	2
Solute carrier family 22 member 8	0	1	0	2
Solute carrier family 22 member 7	0	0	0	1
Solute carrier organic anion transporter family member 2A1	0	1	0	2
Solute carrier family 22 member 11	0	0	0	1
Solute carrier organic anion transporter family member 1B2	0	0	0	1
Solute carrier family 22 member 7	0	0	0	1
aryl hydrocarbon receptor	7	0	0	7
Chain A, Putative fructose-1,6-bisphosphate aldolase	3	0	0	3
Genome polyprotein	0	1	1	2
Luciferase	8	0	0	8
chaperonin-containing TCP-1 beta subunit homolog	1	0	0	1
ATAD5 protein, partial	4	0	0	4
hypothetical protein, conserved	1	0	0	1
bromodomain adjacent to zinc finger domain 2B	6	0	0	6
thyrotropin-releasing hormone receptor	3	0	0	3
eyes absent homolog 2 isoform a	1	0	0	1
relaxin receptor 1 isoform 1	1	0	0	1
Flavin reductase (NADPH)	0	0	1	1
large T antigen	0	1	0	1
endonuclease IV	1	0	0	1
progesterone receptor	8	0	0	8
cytochrome P450 2D6 isoform 1	3	0	0	3
muscleblind-like protein 1 isoform 1	1	0	0	1
Gamma-aminobutyric acid receptor subunit pi	0	2	0	2
Gamma-aminobutyric acid receptor subunit delta	0	2	0	2
Bile salt export pump	0	5	0	5
Gamma-aminobutyric acid receptor subunit alpha-1	0	2	0	2
Gamma-aminobutyric acid receptor subunit beta-1	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-2	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-3	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-1	0	2	1	3
Gamma-aminobutyric acid receptor subunit beta-1	0	2	0	2
Gamma-aminobutyric acid receptor subunit gamma-2	0	2	1	3
5-hydroxytryptamine receptor 1A	0	6	1	8
Gamma-aminobutyric acid receptor subunit alpha-4	0	2	0	2
Gamma-aminobutyric acid receptor subunit gamma-2	0	2	0	2
Gamma-aminobutyric acid receptor subunit beta-3	0	2	1	3
Gamma-aminobutyric acid receptor subunit alpha-5	0	2	1	3
Gamma-aminobutyric acid receptor subunit alpha-3	0	2	1	3
Gamma-aminobutyric acid receptor subunit alpha-2	0	2	0	2
Gamma-aminobutyric acid receptor subunit beta-2	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-4	0	2	0	2
Gamma-aminobutyric acid receptor subunit epsilon	0	2	0	2
TAR DNA-binding protein 43	2	0	0	2
Gamma-aminobutyric acid receptor subunit alpha-6	0	2	0	2
Gamma-aminobutyric acid receptor subunit gamma-1	0	2	0	2
Gamma-aminobutyric acid receptor subunit gamma-3	0	2	0	2
Gamma-aminobutyric acid receptor subunit theta	0	2	0	2
caspase 7, apoptosis-related cysteine protease	3	0	0	3
estrogen receptor 2 (ER beta)	8	0	0	8
pregnane X nuclear receptor	12	0	0	12
caspase-3	3	0	0	3
Caspase-7	2	0	0	2
NPC intracellular cholesterol transporter 1 precursor	2	0	0	2
D(1A) dopamine receptor	2	0	0	2
caspase-3	2	0	0	2
huntingtin isoform 2	1	0	0	1
atrial natriuretic peptide receptor 2 precursor	2	0	0	2
ras-related protein Rab-9A	2	0	0	2
serine/threonine-protein kinase mTOR isoform 1	2	0	0	2
Sodium-dependent noradrenaline transporter	0	1	0	1
Potassium channel subfamily K member 2	0	1	0	1
Albumin	0	0	2	2
Sodium channel protein type 1 subunit alpha	0	1	0	1
Aldo-keto reductase family 1 member B1	0	2	0	2
ATP-dependent translocase ABCB1	0	3	0	4
5-hydroxytryptamine receptor 2C	0	4	0	4
Muscarinic acetylcholine receptor M5	0	3	0	3
Cytochrome P450 2C8	0	3	0	3
Cytochrome P450 2D6	0	4	1	5
Muscarinic acetylcholine receptor M1	0	4	1	5
Cytochrome P450 2C9	0	5	2	7
Angiotensin-converting enzyme	0	4	0	4
Dipeptidyl peptidase 4	0	1	0	1
5-hydroxytryptamine receptor 2A	0	4	0	4
Alpha-1B adrenergic receptor	0	6	1	7
Alpha-2B adrenergic receptor	0	2	1	3
Muscarinic acetylcholine receptor M3	0	5	1	6
Acetylcholinesterase	0	1	0	1
Alpha-2C adrenergic receptor	0	2	1	3
Alpha-2A adrenergic receptor	0	2	1	3
Alpha-1D adrenergic receptor	0	5	1	6
Sodium-dependent noradrenaline transporter	0	2	1	3
Potassium voltage-gated channel subfamily C member 1	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	2	0	2
5-hydroxytryptamine receptor 2A	0	6	1	7
5-hydroxytryptamine receptor 2C	0	6	1	7
5-hydroxytryptamine receptor 2B	0	4	0	4
Sodium-dependent serotonin transporter	0	5	2	7
Sodium-dependent serotonin transporter	0	2	0	2
Cytochrome P450 2C19	0	5	1	6
Alpha-1A adrenergic receptor	0	6	1	7
D(1A) dopamine receptor	2	0	0	2
5-hydroxytryptamine receptor 6	0	7	1	8
Cytochrome P450 2J2	0	3	0	3
D(2) dopamine receptor	0	3	0	3
Gastrin/cholecystokinin type B receptor	0	1	0	1
Sodium-dependent dopamine transporter	0	2	1	3
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	2	0	2
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	2	0	2
Potassium voltage-gated channel subfamily H member 2	0	5	0	5
Cytochrome P450 1B1	0	1	0	1
Sigma intracellular receptor 2	0	1	0	1
Sigma non-opioid intracellular receptor 1	0	1	0	1
Sodium-dependent serotonin transporter	0	1	0	1
Sodium-dependent dopamine transporter	0	1	0	1
Transporter	0	2	0	2
Nuclear receptor subfamily 3 group C member 3	0	4	0	4
Beta-2 adrenergic receptor	0	2	1	4
Sigma non-opioid intracellular receptor 1	0	4	0	4
Sigma non-opioid intracellular receptor 1	0	1	0	1
Transporter	0	2	0	2
Histamine H3 receptor	0	2	0	2
Fucose-binding lectin PA-IIL	0	1	0	1
CD209 antigen	0	2	0	2
Chain B, EUKARYOTIC TRANSLATION INITIATION FACTOR 4E	0	0	1	1
Glycine receptor subunit alpha-1	0	0	2	2
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Sodium- and chloride-dependent glycine transporter 1	0	1	0	1
Large neutral amino acids transporter small subunit 1	0	6	0	6
Serine racemase	0	1	0	1
Olfactory receptor 51E2	0	0	3	3
Sodium- and chloride-dependent glycine transporter 2	0	1	0	1
Free fatty acid receptor 1	0	1	2	4
Free fatty acid receptor 3	0	0	1	1
Free fatty acid receptor 2	0	0	1	1
Cytochrome P450 1A2	0	3	1	4
Sphingosine 1-phosphate receptor 1	0	0	1	1
Peroxisome proliferator-activated receptor delta	0	1	0	2
Free fatty acid receptor 4	0	0	2	2
Free fatty acid receptor 1	0	0	1	1
Hydroxycarboxylic acid receptor 2	0	2	2	4
Chain A, HISTIDINE-BINDING PROTEIN	0	0	1	1
Carbonic anhydrase 12	0	0	0	3
Plasma kallikrein	0	0	0	3
Carbonic anhydrase 3	0	0	0	3
Histidine-binding periplasmic protein	0	0	1	1
Carbonic anhydrase 4	0	0	0	3
Carbonic anhydrase 6	0	1	0	4
Adenosine receptor A1	0	1	0	3
Adenosine receptor A2a	0	0	0	2
Carbonic anhydrase 5A, mitochondrial	0	0	0	3
Carbonic anhydrase	0	0	0	3
Carbonic anhydrase 7	0	0	0	3
Carbonic anhydrase	0	0	0	3
Glutaminyl-peptide cyclotransferase	0	1	0	1
Carbonic anhydrase 9	0	1	1	5
Carbonic anhydrase	0	0	0	3
Carbonic anhydrase	0	0	0	3
Carbonic anhydrase	0	0	0	3
Carbonic anhydrase	0	0	0	3
Carbonic anhydrase 13	0	0	0	1
Carbonic anhydrase 15	0	0	0	3
Carbonic anhydrase 13	0	0	0	2
Carbonic anhydrase 14	0	0	0	3
Carbonic anhydrase 5B, mitochondrial	0	0	0	3
Chain B, Pulmonary surfactant-associated protein D	0	1	0	1
Chain A, Pulmonary surfactant-associated protein D	0	1	0	1
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	3	0	0	3
Amyloid-beta precursor protein	0	4	0	4
Sodium/myo-inositol cotransporter 2	0	1	0	1
Chain A, BETA-SPECTRIN	0	0	1	1
Chain A, Phospholipase C Delta-1	0	0	1	1
Chain A, Inositol 1,4,5-trisphosphate receptor type 1	0	0	1	1
Inositol-trisphosphate 3-kinase A	0	1	0	1
Inositol 1,4,5-trisphosphate receptor type 1	0	0	2	2
Inositol 1,4,5-trisphosphate receptor type 2	0	1	0	1
Inositol 1,4,5-trisphosphate receptor type 3	0	1	1	2
Inositol polyphosphate-5-phosphatase A	0	1	0	1
Inositol 1,4,5-trisphosphate receptor type 1	0	1	1	2
67.9K protein	1	0	0	1
3-oxoacyl-[acyl-carrier-protein] synthase 3	0	1	0	1
N-glycosylase/DNA lyase	0	1	0	1
Myeloperoxidase	0	2	0	2
Formamidopyrimidine-DNA glycosylase	0	1	0	1
DNA gyrase subunit A	0	1	0	1
DNA gyrase subunit B	0	1	0	1
Cytochrome P450 2A6	0	1	0	1
Macrophage migration inhibitory factor	0	1	0	1
Endonuclease III-like protein 1	0	1	0	1
DNA gyrase subunit B	0	1	0	1
DNA gyrase subunit A	0	1	0	1
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	1	0	2
Pantothenate synthetase	0	1	0	1
Isocitrate lyase	0	1	0	1
Putative FAD-containing monooxygenase MymA	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Endonuclease 8-like 1	0	1	0	1
Chain A, AMINOPEPTIDASE	0	1	0	1
Chain A, AMINOPEPTIDASE	0	1	0	1
Chain A, Leucine Aminopeptidase	0	1	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	2	0	2
Intestinal-type alkaline phosphatase	0	2	0	2
Phospholipase A-2-activating protein	0	2	0	2
Leukotriene B4 receptor 1	0	2	0	2
Leukotriene B4 receptor 2	0	1	0	1
Canalicular multispecific organic anion transporter 1	0	1	0	1
P2Y purinoceptor 12	0	0	1	1
Cysteinyl leukotriene receptor 2	0	0	1	1
Cysteinyl leukotriene receptor 1	0	0	1	1
Sterol O-acyltransferase 1	0	2	0	2
Fatty acid-binding protein, heart	0	2	0	2
Seed linoleate 13S-lipoxygenase-1	0	2	0	2
Tyrosine-protein phosphatase non-receptor type 7	0	1	0	1
Sterol O-acyltransferase 1	0	2	0	2
Aldo-keto reductase family 1 member C3	0	1	0	1
Dual specificity protein phosphatase 3	0	1	0	1
Translocator protein	0	1	0	1
Chain A, Methionyl-tRNA synthetase	0	0	1	1
Chain A, Methionyl-tRNA synthetase	0	0	1	1
Chain A, Aminopeptidase	0	1	0	1
Chain A, Methionine aminopeptidase	0	1	0	1
S-ribosylhomocysteine lyase	0	1	0	1
Adenylate cyclase type 5	0	0	0	1
S-adenosylmethionine synthase isoform type-1	0	0	0	1
S-adenosylmethionine synthase isoform type-2	0	0	0	1
Fatty acid synthase	0	1	0	1
tumor susceptibility gene 101 protein	1	0	0	1
Serine racemase	0	1	0	1
Chain B, Exotoxin A	0	0	1	1
Chain B, Exotoxin A	0	0	1	1
Chain B, Exotoxin A	0	0	1	1
Neutrophil elastase	0	1	0	1
Nitric oxide synthase, endothelial	0	1	0	1
Collagenase 3	0	1	0	1
glp-1 receptor, partial	1	0	0	1
lysosomal alpha-glucosidase preproprotein	1	0	0	1
Cholesteryl ester transfer protein	0	1	0	1
D-amino-acid oxidase	0	1	0	1
Hydroxycarboxylic acid receptor 3	0	0	1	1
Nicotinamidase	0	1	0	1
Hydroxycarboxylic acid receptor 2	0	0	1	1
Multidrug and toxin extrusion protein 1	0	2	0	2
D-aspartate oxidase	0	1	0	1
Hydroxycarboxylic acid receptor 2	0	1	1	2
Chain A, Adipocyte Lipid-binding Protein	0	0	1	1
Chain A, MUSCLE FATTY ACID BINDING PROTEIN	0	0	2	2
Chain A, MUSCLE FATTY ACID BINDING PROTEIN	0	0	2	2
Chain A, MUSCLE FATTY ACID BINDING PROTEIN	0	0	2	2
Chain A, BCL-2-RELATED PROTEIN A1	0	0	1	1
putative potassium channel subunit	0	0	1	1
serine-protein kinase ATM isoform a	1	0	0	1
histone-lysine N-methyltransferase 2A isoform 2 precursor	2	0	0	2
bcl-2-like protein 11 isoform 1	0	0	1	1
Fatty acid-binding protein, liver	0	1	1	2
DNA topoisomerase 1	0	1	0	1
Protein kinase C alpha type	0	1	1	3
Tyrosine-protein phosphatase non-receptor type 1	0	3	0	3
Rap guanine nucleotide exchange factor 4	1	0	0	1
Chain A, ARGINASE 1	0	1	0	1
Chain A, Arginase 1	0	1	0	1
Chain A, ARGINASE 1	0	1	0	1
Chain A, L-ARGININE\\:GLYCINE AMIDINOTRANSFERASE	0	1	0	1
Solute carrier family 2, facilitated glucose transporter member 9	0	2	2	4
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Pyruvate kinase, M2 isozyme	0	1	0	1
Chain A, Phosphonopyruvate hydrolase	0	1	0	1
Chain A, Phosphoenolpyruvate-protein phosphotransferase	0	1	0	1
Proto-oncogene tyrosine-protein kinase Src	0	1	0	1
Chain A, Fatty acid-binding protein, adipocyte	0	1	0	1
nuclear receptor subfamily 1, group I, member 2	2	0	0	2
Acetylcholinesterase	0	3	0	3
Toll-like receptor 2	0	1	0	1
Cystathionine gamma-lyase	0	1	0	1
Succinyl-diaminopimelate desuccinylase	0	1	0	1
Chain D, PROTEIN (PHOSPHOGLYCERATE MUTASE 1)	0	1	0	1
Chain A, PROTEIN (PHOSPHOGLYCERATE MUTASE 1)	0	1	0	1
Chain A, Beta-arrestin 1	0	0	1	1
Beta-lactamase	0	1	0	1
Beta-lactamase	0	1	1	2
Nicotinate phosphoribosyltransferase	0	1	0	1
Transmembrane prolyl 4-hydroxylase	0	1	0	1
Peroxisomal sarcosine oxidase	0	0	0	1
luciferase	0	0	0	1
Estrogen receptor	0	2	0	2
Glucocorticoid receptor	0	2	1	8
Progesterone receptor	0	2	0	3
Glucocorticoid receptor	0	1	1	2
Glucocorticoid receptor	0	0	1	1
Glycine receptor subunit alpha-1	0	2	0	2
Corticosteroid-binding globulin	0	1	0	1
Mineralocorticoid receptor	0	2	1	3
Androgen receptor	0	2	0	2
Glutamine synthetase	0	0	1	1
Androgen receptor	0	1	0	1
Glycine receptor subunit beta	0	2	0	2
Glycine receptor subunit alpha-2	0	2	0	2
Glycine receptor subunit alpha-3	0	2	0	2
Histamine H1 receptor	0	1	1	2
Nociceptin receptor	0	0	1	1
Estrogen receptor beta	0	2	0	2
Glutamate 5-kinase	0	0	0	1
Angiotensin-converting enzyme	0	1	0	1
Neutral amino acid transporter A	0	1	0	1
Neutral amino acid transporter B(0)	0	1	0	1
Amino acid transporter	0	1	0	1
Beta-1 adrenergic receptor	0	1	1	3
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Albumin	0	0	1	1
Beta-2 adrenergic receptor	0	2	1	3
Muscarinic acetylcholine receptor M2	0	2	1	3
Beta-1 adrenergic receptor	0	2	1	3
5-hydroxytryptamine receptor 1A	0	2	2	4
Adenosine receptor A3	0	3	1	4
Beta-2 adrenergic receptor	0	2	0	3
Beta-3 adrenergic receptor	0	2	1	3
D(2) dopamine receptor	0	3	1	4
Beta-1 adrenergic receptor	0	4	1	6
D(3) dopamine receptor	0	2	0	2
D(1A) dopamine receptor	0	3	1	4
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Alpha-1D adrenergic receptor	0	2	1	4
Endothelin-1 receptor	0	1	1	2
Beta-3 adrenergic receptor	0	2	0	2
5-hydroxytryptamine receptor 1B	0	2	1	3
5-hydroxytryptamine receptor 1B	0	4	0	4
Adenosine receptor A2a	0	1	1	2
Neuromedin-K receptor	0	0	1	1
Type-1 angiotensin II receptor	0	1	1	2
Cholecystokinin receptor type A	0	1	1	2
5-hydroxytryptamine receptor 7	0	2	1	3
Beta-1 adrenergic receptor	0	1	0	1
Alpha-1A adrenergic receptor	0	3	2	6
Alpha-1B adrenergic receptor	0	1	1	3
Mu-type opioid receptor	0	1	1	2
Vasopressin V1a receptor	0	1	1	2
Delta-type opioid receptor	0	1	1	2
Kappa-type opioid receptor	0	1	1	2
5-hydroxytryptamine receptor 2B	0	6	1	7
5-hydroxytryptamine receptor 7	0	1	0	1
Beta-2 adrenergic receptor	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	2	0	2
Sodium channel protein type 5 subunit alpha	0	2	0	2
Sodium/bile acid cotransporter	0	1	0	1
Nuclear receptor subfamily 2 group E member 1	0	0	2	2
Pyridoxal kinase	0	0	0	1
Monocarboxylate transporter 4	0	0	0	1
Monocarboxylate transporter 2	0	0	0	1
Monocarboxylate transporter 1	0	0	0	1
C-terminal-binding protein 2	0	1	0	1
Monocarboxylate transporter 2	0	1	0	1
Prolyl 4-hydroxylase	0	1	0	1
Alpha-ketoglutarate-dependent dioxygenase FTO	0	1	0	1
Chain A, PLASMA RETINOL-BINDING PROTEIN PRECURSOR	0	0	1	1
interleukin 8	1	0	0	1
pregnane X receptor	3	0	0	3
Retinol-binding protein 4	0	0	1	1
Beta-lactoglobulin	0	0	1	1
Alpha-synuclein	0	2	0	2
Smad3	1	0	0	1
transcriptional regulator ERG isoform 3	1	0	0	1
Voltage-dependent L-type calcium channel subunit alpha-1F	0	1	0	1
Muscarinic acetylcholine receptor M4	0	1	0	1
D	0	1	0	1
D(4) dopamine receptor	0	1	0	1
Histamine H2 receptor	0	2	0	2
5-hydroxytryptamine receptor 7	0	1	0	1
5-hydroxytryptamine receptor 2C	0	1	0	1
5-hydroxytryptamine receptor 2A	0	1	0	1
Histamine H1 receptor	0	2	0	2
D(3) dopamine receptor	0	2	0	2
3-hydroxy-3-methylglutaryl-coenzyme A reductase	0	1	0	1
D(2) dopamine receptor	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	1	0	1
5-hydroxytryptamine receptor 2B	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	1	0	1
5-hydroxytryptamine receptor 1A	0	1	0	1
Multidrug and toxin extrusion protein 2	0	1	0	1
PPM1D protein	1	0	0	1
nonstructural protein 1	2	0	0	2
cytochrome P450 2C9 precursor	1	0	0	1
atrial natriuretic peptide receptor 1 precursor	1	0	0	1
DNA polymerase beta	1	0	0	1
neuropeptide S receptor isoform A	1	0	0	1
Pancreatic triacylglycerol lipase	0	1	0	1
NADH-ubiquinone oxidoreductase chain 1	0	1	0	1
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial	0	1	0	1
Dihydroorotate dehydrogenase (fumarate)	0	1	0	1
Acyl carrier protein, mitochondrial	0	1	0	1
Dihydroorotate dehydrogenase	0	1	0	1
Met repressor	0	0	2	2
Protein arginine N-methyltransferase 5	0	0	1	1
Histone H3K27 methylase	0	0	0	1
Phenylethanolamine N-methyltransferase	0	0	1	2
S-adenosylmethionine decarboxylase proenzyme	0	1	0	2
Protein-L-isoaspartate(D-aspartate) O-methyltransferase	0	1	0	1
Catechol O-methyltransferase	0	0	0	1
Protein arginine N-methyltransferase 1	0	1	0	1
Methylosome protein 50	0	0	1	1
Chain A, Porphobilinogen Synthase	0	1	0	1
Chain A, Porphobilinogen Synthase	0	1	0	1
Chain A, Porphobilinogen Synthase	0	1	0	1
nuclear factor NF-kappa-B p105 subunit isoform 1	1	0	0	1
Chain A, MALTOPORIN	0	0	1	1
Chain B, MALTOPORIN	0	0	1	1
UDP-glucuronosyltransferase 2B7	0	0	0	1
Cytochrome P450 3A5	0	1	0	1
UDP-glucuronosyltransferase 1A4	0	0	0	1
Serine/threonine-protein kinase mTOR	0	1	0	1
Peptidyl-prolyl cis-trans isomerase FKBP1A	0	2	1	3
Peptidyl-prolyl cis-trans isomerase FKBP1B	0	0	1	1
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	0	1	0	1
Peptidyl-prolyl cis-trans isomerase FKBP5	0	1	0	1
Splicing factor 3B subunit 3	0	1	0	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	1	0	1
glucocerebrosidase	1	0	0	1
Sodium- and chloride-dependent taurine transporter	0	1	0	1
Serine/threonine-protein kinase D3	0	0	1	1
Protein kinase C gamma type	0	1	1	2
Protein kinase C beta type	0	1	1	2
Luciferin 4-monooxygenase	0	0	1	1
Protein kinase C eta type	0	0	1	1
Protein kinase C iota type	0	0	1	1
Protein kinase C epsilon type	0	1	1	2
Protein kinase C theta type	0	0	1	1
Protein kinase C zeta type	0	0	1	1
Protein kinase C delta type	0	1	1	2
Serine/threonine-protein kinase D1	0	0	1	1
Ras guanyl-releasing protein 3	0	0	1	1
Cereblon isoform 4	0	2	0	2
Prostaglandin G/H synthase 1	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4C	0	1	0	1
DNA-binding protein Ikaros	0	0	0	1
DNA damage-binding protein 1	0	1	1	2
Protein cereblon	0	2	1	4
Chain A, ykoF	0	0	1	1
Chain B, ykoF	0	0	1	1
Chain A, ThiT	0	0	1	1
Thiamine transporter ThiT	0	0	1	1
Transketolase	0	0	1	1
Thiamine-binding periplasmic protein	0	0	1	1
Thymidine kinase	0	1	0	2
Thymidine kinase, cytosolic	0	2	0	4
Thymidine kinase	0	1	0	2
Thymidylate synthase	0	0	0	1
Thymidine phosphorylase	0	0	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	1
Glucose-6-phosphate 1-dehydrogenase	0	1	0	1
Thymidine phosphorylase	0	0	0	1
Thymidylate kinase	0	1	0	1
Thymidine kinase, cytosolic	0	0	0	2
Thymidine kinase	0	0	0	1
Thymidylate kinase	0	1	0	1
Thymidine kinase	0	1	0	2
Sterol O-acyltransferase 1	0	1	0	1
Thymidine kinase	0	0	0	1
Thymidine kinase	0	0	0	1
Chain A, Nuclear Receptor ROR-beta	0	1	0	1
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	2	0	0	2
Parkin	1	0	0	1
Ornithine decarboxylase	0	0	0	1
Ornithine decarboxylase	0	0	0	1
Retinoic acid receptor alpha	0	2	2	7
Retinoic acid receptor beta	0	2	2	7
Retinoic acid receptor alpha	0	1	2	3
Retinoic acid receptor gamma	0	2	2	7
Alpha-1A adrenergic receptor	0	1	0	1
Retinoic acid receptor gamma	0	1	2	3
Retinoic acid receptor RXR-alpha	0	2	2	4
Retinoic acid receptor beta	0	1	2	3
Cellular retinoic acid-binding protein 2	0	0	1	1
Mitogen-activated protein kinase 1	0	1	0	1
Retinoic acid receptor RXR-alpha	0	1	2	3
Retinoic acid receptor RXR-beta	0	2	2	4
Retinoic acid receptor RXR-beta	0	1	2	3
Retinoic acid receptor RXR-gamma	0	1	2	3
Indoleamine 2,3-dioxygenase 1	0	1	0	1
Nuclear receptor ROR-alpha	0	1	0	1
Cellular retinoic acid-binding protein 1	0	1	0	2
Retinoic acid receptor RXR-gamma	0	2	2	4
Cellular retinoic acid-binding protein 1	0	0	1	1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	0	2	1	3
Indoleamine 2,3-dioxygenase 2	0	1	0	1
Nuclear receptor ROR-beta	0	1	0	1
Chain A, CARBONIC ANHYDRASE II	0	1	0	1
Chain A, Trp Rna-binding Attenuation Protein	0	0	1	1
Chain K, Trp Rna-binding Attenuation Protein	0	0	1	1
Chain B, tryptophanyl-tRNA synthetase	0	0	1	1
Chain C, Tryptophanyl-tRNA synthetase II	0	0	1	1
Dihydrofolate reductase	0	2	0	2
Stromelysin-1	0	1	0	1
Indoleamine 2,3-dioxygenase 1	0	1	0	2
Substance-P receptor	0	1	0	1
Tryptophan 2,3-dioxygenase	0	1	0	2
SLC16A10 protein	0	0	0	2
Uracil nucleotide/cysteinyl leukotriene receptor	0	1	0	1
Tryprostatin B synthase	0	0	0	1
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	0	0	1	1
Monocarboxylate transporter 10	0	0	0	2
Chain A, CHORISMATE MUTASE	0	1	0	1
Chain A, TYROSYL-tRNA SYNTHETASE	0	0	1	1
Tubulin--tyrosine ligase	0	1	0	1
Taste receptor type 2 member 14	0	0	0	1
Urease subunit alpha	0	1	0	1
Urease subunit beta	0	1	0	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Guanine deaminase	0	1	0	1
Carbonic anhydrase	0	1	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(23)

Research Excerpts

Overview

Context

Treatment

Research

Studies (293)

Protein Targets (880)

Adult Refsum Disease

Synonyms(23)

Research Excerpts

Overview

Context

Treatment

Research

Studies (293)

Drugs Studied (147)

Protein Targets (880)