ascorbic-acid and Hydronephrosis

Malacoplakia is a rare chronic inflammatory disease that most commonly involves the genitourinary tract with a wide spectrum of clinical presentation.. A 65-year-old woman presented with obstructive nephropathy with bilateral hydroureteronephrosis. Bilateral nephrostomy-tube placement saw an improvement in her renal function. A computerized tomography (CT) scan with contrast showed suspect lesions in the bladder, which were confirmed by cystoscopy. A transurethral resection of the suspect areas of bladder on histological examination confirmed the diagnosis of malacoplakia. Bilateral ureteral recanalization was performed with placement of ureteral stents, after balloon dilation of strictures. The treatment was continued with ascorbic acid 500 mg daily and ciprofloxacin 500 mg once daily.. Malacoplakia is a rare disease. Treatment is not standard and depends on the disease location. Malacoplakia that is isolated to the lower genitourinary tract, after a transurethral resection indicating to obtain a biopsy and debulking, can typically be treated with medication, whereas upper tract disease commonly requires a combination of medical and surgical intervention.

Topics: Aged; Anti-Bacterial Agents; Ascorbic Acid; Ciprofloxacin; Female; Humans; Hydronephrosis; Malacoplakia; Renal Insufficiency; Stents; Treatment Outcome; Urinary Bladder; Urinary Catheterization; Urinary Tract Infections; Vitamins

We report a case of malacoplakia in the ureter and bladder. A 78-year-old woman was admitted to our department for detailed examination of hydronephrosis. A small-fingertip-sized tumorous yellowish white lesion was detected by cytoscopy at a site that appeared to be the right side of the ureteral orifice. Transurethral resection was performed on the same site. Flat yellowish white protruding lesions were seen at two sites on the right ureter. Michaelis-Gutmann bodies were observed in biopsy specimens from both the bladder and ureter, and a diagnosis of malacoplakia was made. Ascorbic acid and bethanechol chloride were administered postoperatively. Endoscopy performed three months after the operation showed that the protruding lesions in the bladder and ureter had disappeared. Narrowing of the ureter or vesicoureteral reflux has not been seen to date.

Topics: Aged; Ascorbic Acid; Bethanechol Compounds; Drug Therapy, Combination; Female; Humans; Hydronephrosis; Malacoplakia; Ureteral Diseases; Urinary Bladder Diseases

Topics: Animals; Ascorbic Acid; Chronic Disease; Citrates; Drug Therapy, Combination; Hydronephrosis; Hypertension, Renal; Ketoglutaric Acids; Kidney; Malates; Oxidative Phosphorylation; Pyelonephritis; Rats; Solutions; Succinates

Topics: Adult; Aged; Aneurysm; Ascorbic Acid; Female; Glomerular Filtration Rate; Humans; Hydronephrosis; Hypertension, Renal; Iodine Radioisotopes; Iodohippuric Acid; Isotope Labeling; Kidney; Kidney Calculi; Kidney Diseases, Cystic; Kidney Neoplasms; Male; Middle Aged; Pyelonephritis; Quality Control; Radioisotope Renography; Renal Artery; Renal Artery Obstruction; Technetium; Urinary Calculi

Topics: Adult; Ascorbic Acid; Cell Nucleus; Cystoscopy; Eosinophils; Epithelial Cells; Female; Histiocytes; Humans; Hydronephrosis; Kidney Pelvis; Lymphocytes; Malacoplakia; Methenamine; Neutrophils; Plasma Cells; Ureteral Obstruction; Urinary Bladder; Urinary Bladder Diseases; Urography

Topics: Adult; Ascorbic Acid; Blood Urea Nitrogen; Creatinine; Humans; Hydronephrosis; Male; Methenamine; Quadriplegia; Urinary Catheterization; Urography