Any hydroxyflavone in which two ring hydrogens are replaced by hydroxy substituents.
| Member | Definition | Role |
|---|
| 3',4',5'-O-trimethyltricetin | A trimethoxyflavone that is the 3',4',5'-tri-O-methyl ether of tricetin. | 3',4',5'-O-trimethyltricetin |
| 4',6-dihydroxy-5,7-dimethoxyflavone | A dimethoxyflavone that is the 5,7-dimethyl ether derivative of scutellarein. | 4',6-dihydroxy-5,7-dimethoxyflavone |
| 4',6-dihydroxyflavone | A dihydroxyflavone that is flavone substituted by hydroxy groups at positions 4' and 6. | 4',6-dihydroxyflavone |
| 4',7-dihydroxyflavone | A dihydroxyflavone in which the two hydroxy substituents are located at positions 4' and 7. | 4',7-dihydroxyflavone |
| 5,4'-dihydroxy-7,3'-dimethoxyflavone | A dimethoxyflavone that is luteolin in which the hydroxy groups at positions 7 and 3' are replaced by methoxy groups. | velutin |
| 5,7-dihydroxy-4',6-dimethoxyflavone | A dimethoxyflavone that is the 6,4'-dimethyl ether derivative of scutellarein. | pectolinarigenin |
| 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one | A dihydroxy- and monomethoxy-flavone in which the hydroxy groups are positioned at C-5 and C-7 and the methoxy group is at C-6. | oroxylin A |
| 6-prenylchrysin | A dihydroxyflavone that is chrysin substituted by a prenyl group at position 6. | 6-(3,3-dimethylallyl)chrysin |
| 7,8-dihydroxyflavone | A dihydroxyflavone that is flavone substituted by hydroxy groups at positions 7 and 8. A dihydroxyflavone that is flavone substituted by hydroxy groups at positions 7 and 8. A naturally occurring flavonoid produced by several plants, including the weed Tridax procumbens (coalbuttons or tridax daisy) and the tree Godmania aesculifolia, In animal models, it has shown efficacy against several diseases of the nervous system, including Alzheimer's, Parkinson's, and Huntington's. | 7,8-dihydroxyflavone |
| acacetin | A monomethoxyflavone that is the 4'-methyl ether derivative of apigenin. | 5,7-dihydroxy-4'-methoxyflavone |
| alvocidib | A synthetic dihydroxyflavone that is 5,7-dihydroxyflavone which is substituted by a 3-hydroxy-1-methylpiperidin-4-yl group at position 8 and by a chlorine at the 2' position (the (-)-3S,4R stereoisomer). A cyclin-dependent kinase 9 (CDK9) inhibitor, it has been studied for the treatment of acute myeloid leukaemia, arthritis and atherosclerotic plaque formation. | alvocidib |
| apigetrin | A glycosyloxyflavone that is apigenin substituted by a beta-D-glucopyranosyl moiety at position 7 via a glycosidic linkage. | apigenin 7-O-beta-D-glucoside |
| apiin | A beta-D-glucoside having a beta-D-apiosyl residue at the 2-position and a 5,4'-dihydroxyflavon-7-yl moiety at the anomeric position. | apiin |
| ayanin | A trimethoxyflavone that is quercetin in which the hydroxy groups at positions 3, 4' and 7 have been replaced by methoxy groups. | 3',5-dihydroxy-3,4',7-trimethoxyflavone |
| baicalin | The glycosyloxyflavone which is the 7-O-glucuronide of baicalein. It is an active ingredient of Chinese herbal medicine Scutellaria baicalensis. | baicalin |
| casticin | A tetramethoxyflavone that consists of quercetagetin in which the hydroxy groups at positions 3, 6, 7 and 4' have been replaced by methoxy groups. It has been isolated from Eremophila mitchellii. | casticin |
| chrysin | A dihydroxyflavone in which the two hydroxy groups are located at positions 5 and 7. | chrysin |
| chrysosplenetin b | A tetramethoxyflavone that is the 3,6,7,3'-tetramethyl ether derivative of quercetagetin. | chrysosplenetin |
| cirsilineol | A trimethoxyflavone that is flavone substituted by methoxy groups at positions 6, 7 and 3' and hydroxy groups at positions 5 and 4' respectively. | cirsilineol |
| cirsimaritin | A dimethoxyflavone that is flavone substituted by methoxy groups at positions 6 and 7 and hydroxy groups at positions 5 and 4' respectively. | cirsimaritin |
| ermanin | A dimethoxyflavone that is kaempferol in which the hydroxy groups at position 3 and 4' have been replaced by methoxy groups. It is a component of bee glue and isolated from several plant species including Tanacetum microphyllum. | 3,4'-dimethylkaempferol |
| eupatilin | A trimethoxyflavone that is flavone substituted by hydroxy groups at C-5 and C-7 and methoxy groups at C-6, C-3' and C-4' respectively. Isolated from Citrus reticulata and Salvia tomentosa, it exhibits anti-inflammatory, anti-ulcer and antineoplastic activities. | eupatilin |
| eupatorin | A trimethoxyflavone that is 6-hydroxyluteolin in which the phenolic hydogens at positions 4', 6 and 7 have been replaced by methyl groups. | eupatorin |
| genkwanin | A monomethoxyflavone that is apigenin in which the hydroxy group at position 7 is methylated. | genkwanin |
| ladanein | A dimethoxyflavone that is scutellarein in which the hydroxy groups at positions 4' and 7 are replaced by methoxy groups. It is an effective anti-HCV agent. | ladanein |
| lespenefril | A glycosyloxyflavone that is kaempferol attached to alpha-L-rhamnopyranosyl residues at positions 3 and 7 respectively via glycosidic linkages. It has been isolated from the aerial parts of Vicia faba and Lotus edulis. | kaempferol 3,7-di-O-alpha-L-rhamnoside |
| nevadensin | A trimethoxyflavone that is flavone substituted by methoxy groups at positions 6, 8 and 4' and hydroxy groups at positions 5 and 7 respectively. | nevadensin |
| pachypodol | A trimethoxyflavone that is quercetin in which the hydroxy groups at position 3, 7 and 3' are replaced by methoxy groups. It has been isolated from Combretum quadrangulare and Euodia elleryana. | pachypodol |
| rhoifolin | An apigenin derivative having an alpha-(1->2)-L-rhamnopyranosyl)-beta-D-glucopyranosyl moiety attached to the 7-hydroxy group. | apigenin 7-O-neohesperidoside |
| robinin | A glycosyloxyflavone that is kaempherol substituted by a 6-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-galactopyranosyl residue at position 3 and a 6-deoxy-alpha-L-mannopyranosyl residue at position 7 via a glycosidic linkage. | robinin |
| santin | A trimethoxyflavone that is flavone substituted by methoxy groups at positions 3, 6 and 4' and hydroxy groups at positions 5 and 7 respectively. | santin |
| saponarin | A C-glycosyl compound that is isovitexin in which the hydroxyl hydrogen at position 7 is replaced by a beta-D-glucosyl residue. | 7-O-(beta-D-glucosyl)isovitexin |
| sideroxylin | A monomethoxyflavone that is flavone substituted by a methoxy group at position 7, hydroxy groups at positions 5 and 4' and methyl groups at positions 6 and 8. It has been isolated from Hydrastis canadensis and Eucalyptus species. | sideroxylin |
| skullcapflavone ii | A tetramethoxyflavone that is flavone substituted by methoxy groups at positions 6, 7, 8 and 6' and hydroxy groups at positons 5 and 2' respectively. | scullcapflavone II |
| spinosin | A flavone C-glycoside that is flavone substituted by hydroxy groups at positions 5 and 4', a methoxy group at position 7 and a 2-O-beta-D-glucopyranosyl-beta-D-glucopyranosyl residue at position 6 via a C-glycosidic linkage. | spinosin |
| swertisin | A flavone C-glycoside that is 7-O-methylapigenin in which the hydrogen at position 6 has been replaced by a beta-D-glucosyl residue. | swertisin |
| wogonin | A dihydroxy- and monomethoxy-flavone in which the hydroxy groups are positioned at C-5 and C-7 and the methoxy group is at C-8. | wogonin |
| xanthomicrol | A trimethoxyflavone that is flavone substituted by methoxy groups at positions 6, 7 and 8 and hydroxy groups at positions 5 and 4'. | xanthomicrol |