An EC 6.4.1.* (carboxylase) inhibitor that interferes with the action of pyruvate carboxylase (EC 6.4.1.1).
ChEBI ID: 90318
| Member | Definition | Class |
|---|---|---|
| phenylacetic acid | A monocarboxylic acid that is toluene in which one of the hydrogens of the methyl group has been replaced by a carboxy group. | phenylacetic acid |
| phenylpyruvic acid | A 2-oxo monocarboxylic acid that is 3-phenylpropanoic acid substituted by an oxo group at position 2. It is an intermediate metabolite in the phenylalanine pathway. | keto-phenylpyruvic acid |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 307 (29.18) | 18.7374 |
| 1990's | 199 (18.92) | 18.2507 |
| 2000's | 269 (25.57) | 29.6817 |
| 2010's | 214 (20.34) | 24.3611 |
| 2020's | 63 (5.99) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 21 (1.87%) | 5.53% |
| Reviews | 34 (3.02%) | 6.00% |
| Case Studies | 25 (2.22%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 1,044 (92.88%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| cytochrome P450 2D6 | Homo sapiens (human) | Potency | 15.4871 | 1 | 1 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 47.9478 | 2 | 2 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 10.9622 | 1 | 1 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 29.9396 | 2 | 4 |
| nuclear receptor subfamily 1, group I, member 3 | Homo sapiens (human) | Potency | 51.4390 | 3 | 5 |
| peroxisome proliferator activated receptor gamma | Homo sapiens (human) | Potency | 26.8325 | 1 | 1 |
| RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 29.8493 | 1 | 1 |
| retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 68.5896 | 2 | 2 |
| thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 14.9601 | 1 | 1 |
| thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 30.1358 | 3 | 3 |
| v-jun sarcoma virus 17 oncogene homolog (avian) | Homo sapiens (human) | Potency | 58.1965 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Aldo-keto reductase family 1 member B1 | Homo sapiens (human) | IC50 | 96.0000 | 1 | 1 |
| Aldo-keto reductase family 1 member B1 | Homo sapiens (human) | Ki | 253.0000 | 1 | 3 |
| C-terminal-binding protein 2 | Homo sapiens (human) | IC50 | 116.3000 | 1 | 1 |
| Prolyl 4-hydroxylase subunit alpha-1 | Gallus gallus (chicken) | Ki | 20,000.0000 | 1 | 1 |
| Solute carrier family 22 member 20 | Mus musculus (house mouse) | Ki | 28.9202 | 1 | 2 |
| Solute carrier family 22 member 6 | Mus musculus (house mouse) | Ki | 79.1443 | 2 | 3 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Olfactory receptor class A-like protein 1 | Danio rerio (zebrafish) | EC50 | 30.5000 | 1 | 1 |
| Tyrosine-protein kinase Lck | Homo sapiens (human) | Kd | 50,000.0000 | 1 | 1 |