Compounds > coumarin 7
Page last updated: 2024-12-07

coumarin 7

Description

Coumarin 7 is a fluorescent dye with a high quantum yield and excellent photostability. It is commonly used in fluorescence microscopy, flow cytometry, and other biological applications. Coumarin 7 is synthesized through a multi-step process involving the condensation of salicylaldehyde with a suitable aromatic ketone. The resulting coumarin derivative can then be further modified to obtain Coumarin 7. This dye exhibits strong absorption in the ultraviolet region and emits green fluorescence upon excitation. The high quantum yield and photostability of Coumarin 7 make it a valuable tool for imaging and studying cellular processes. Its ability to penetrate cell membranes allows researchers to track the movement and distribution of molecules within cells. Coumarin 7 is also used in various sensing applications, such as detecting specific ions or molecules. The unique spectral properties and high sensitivity of this dye make it a powerful tool for studying biological systems. Its applications extend to areas like cell biology, bioimaging, and drug discovery. Coumarin 7 is widely studied because of its potential applications in various fields, including biomedical research, environmental monitoring, and material science. Researchers are constantly exploring new ways to use Coumarin 7 for various purposes. The high quantum yield and photostability of Coumarin 7 make it a valuable tool for researchers studying various aspects of biology and chemistry.'

coumarin 7: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID94381
CHEMBL ID374632
SCHEMBL ID180716
MeSH IDM0506876

Synonyms (73)

Synonym
coumarin,
BIDD:GT0472
AKOS000415301
OPREA1_440779
nsc-303254
coumarin, 3-(2-benzimidazolyl)-7-(diethylamino)-
2h-1-benzopyran-2-one, 3-(1h-benzimidazol-2-yl)-7-(diethylamino)-
3-(2-benzimidazolyl)-7-(diethylamino)coumarin
coumarin 7
nsc303254
27425-55-4
3-(1h-benzoimidazol-2-yl)-7-diethylamino-chromen-2-one
3-(1h-benzimidazol-2-yl)-7-(diethylamino)chromen-2-one
3-(1h-benzimidazol-2-yl)-7-(diethylamino)-2h-chromen-2-one
ENAMINE_000185
CBDIVE_006555
smr000103015
MLS000106044 ,
coumarin 7, 98%
STK325581
B2111
KUC105942N
KUC105942
ksc-16-133
CHEMBL374632
cid 94381
HMS1394I09
HMS2467L12
3-(1h-1,3-benzodiazol-2-yl)-7-(diethylamino)-2h-chromen-2-one
einecs 248-451-4
3-(1h-benzimidazol-2-yl)-7-(diethylamino)-2-benzopyrone
3-(benzimidazol-2-yl)-7-diethylaminocoumarin
nsc 303254
FT-0624079
3-(1h-1,3-benzodiazol-2-yl)-7-(diethylamino)chromen-2-one
SCHEMBL180716
REGID_FOR_CID_94381
DTXSID4067309
3-(1h-benzimidazol-2-yl)-7-(diethylamino)-1-benzopyran-2-one
bdbm37601
cid_94381
3-(1h-benzimidazol-2-yl)-7-(diethylamino)coumarin
coumarin7
W-110701
3-(1h-benzimidazol-2-yl)-7-(diethylamino)-2h-chromen-2-one #
3-(benzimidazol-2-yl)-7-(diethylamino)coumarin
3-(1h-benzo[d]imidazol-2-yl)-7-(diethylamino)-2h-chromen-2-one
mfcd00051348
12239-58-6
disperse yellow 82
c.i. disperse yellow 82
sr-01000389310
SR-01000389310-1
AS-71890
Z56758388
coumarin-7
yellow 8gff
3-(2'-benzimidazolyl)-7-(diethylamino)coumarin
disperse yellow 8gff
terasil brilliant flavine 8gff
VX3Q255SG5
d820 savannah yellow
3-(1h-benzimidazol-2-yl)-7-(diethylamino)-2h-1-benzopyran-2-one
fluorescent yellow 10g
sumikaron brilliant flavine s 10g
3-(benzimidazol-2-yl)-7-diethylamino-2h-benzopyran-2-one
F0266-2430
HY-125750
AMY10383
BRD-K85676811-001-08-2
CS-0094880
T70702
SY051291

Research Excerpts

Bioavailability

ExcerptReferenceRelevance
"We formulated nano-encapsulation of a naturally occurring coumarin-scopoletin (7-hydroxy-6-methoxy coumarin, HMC, C(10)H(8)O(4)), isolated from plant Gelsemium sempervirens having anticancer potentials, with a bio-adhesive agent -polylactic-co-glycolic acid (PLGA) and tested if its cellular uptake, bioavailability and apoptotic (anticancer) potentials could thus be increased vis-a-vis unencapsulated HMC."( Polymeric nanoparticle encapsulation of a naturally occurring plant scopoletin and its effects on human melanoma cell A375.
Bhattacharyya, SS; Boujedaini, N; Khuda-Bukhsh, AR; Paul, S, 2010)		0.36
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Occurs in Manufacturing (44 Product(s))

Product Categories

Product CategoryProducts
Beauty & Personal Care36
Household Essentials8

Products

ProductBrandCategoryCompounds Matched from IngredientsDate Retrieved
Alba Botanica Even & Bright Renewing Cream -- 2 ozAlbaBeauty & Personal Careorange, amyl cinnamal, citric acid, ascorbyl palmitate, allantoin, ascorbyl glucoside, ascorbic acid, cetyl alcohol, citric acid, coumarin, coumarin, tocopherol, panthenol, erythritol, triethyl citrate, tocopherol, glycerin, limonene, linalyl acetate, phenoxyethanol, potassium hydroxide, sodium benzoate, sodium citrate, sodium hydroxide, sorbitol, squalane, stearic acid, stearyl alcohol, thioctic acid2024-11-29 10:47:42
Alba Botanica Hawaiian Facial Wash Coconut Milk -- 8 fl ozAlbaBeauty & Personal Carebenzoic acid, cetearyl alcohol, cetyl alcohol, coumarin, coumarin, dehydroacetic acid, panthenol, glycerin, phenoxyethanol, potassium hydroxide, stearic acid2024-11-29 10:47:42
Alba Botanica Mega Moisture Conditioner -- 32 ozAlbaBeauty & Personal Careisopropyl alcohol, citric acid, benzyl salicylate, cetyl alcohol, citric acid, coumarin, coumarin, panthenol, glycerin, phenoxyethanol, sodium benzoate, sodium hydroxide, stearyl alcohol2024-11-29 10:47:42
Alba Botanica Mega Moisture Conditioner Coconut Milk -- 12 fl ozAlbaBeauty & Personal Careisopropyl alcohol, citric acid, benzyl salicylate, cetyl alcohol, citric acid, coumarin, coumarin, panthenol, ethylhexylglycerin, glycerin, phenoxyethanol, sodium benzoate, sodium hydroxide, stearyl alcohol2024-11-29 10:47:42
Alba Botanica More Moisture Shampoo Coconut Milk -- 12 fl ozAlbaBeauty & Personal Careglyceryl oleate, citric acid, benzoic acid, benzyl alcohol, benzyl salicylate, citric acid, coumarin, coumarin, dehydroacetic acid, panthenol, glycerin, phenoxyethanol, sodium benzoate2024-11-29 10:47:42
Alba Botanica Organics Hawaiian Body Oil Kukui Nut -- 8.5 fl ozAlbaBeauty & Personal Carecoumarin, coumarin, tocopherol, tocopherol2024-11-29 10:47:42
Alba Botanica Very Emollient Body Lotion Ocean Surf -- 32 ozAlbaBeauty & Personal Careamyl cinnamaldehyde, citric acid, allantoin, benzoic acid, benzyl salicylate, cetearyl alcohol, cetyl alcohol, citric acid, coumarin, coumarin, dehydroacetic acid, panthenol, triethyl citrate, glycerin, dimethicone, hydroxycitronellal, limonene, phenoxyethanol, potassium hydroxide, sodium benzoate2024-11-29 10:47:42
Alba Botanica® More Moisture Shampoo Coconut Milk -- 32 fl ozAlbaBeauty & Personal Careglyceryl oleate, citric acid, benzoic acid, benzyl alcohol, benzyl salicylate, citric acid, coumarin, coumarin, dehydroacetic acid, panthenol, glycerin, phenoxyethanol, sodium benzoate2024-11-29 10:47:42
Alba Botanica® Very Emollient Bath and Shower Gel French Lavender -- 32 fl ozAlbaBeauty & Personal Carecitric acid, benzyl alcohol, calendula, citric acid, coumarin, coumarin, glyceryl stearate, glycerin, limonene, sodium benzoate2024-11-29 10:47:42
Alba Botanica® Very Emollient Cream Shave Mango Vanilla -- 8 ozAlbaBeauty & Personal Carecaprylyl glycol, benzyl alcohol, carbomer, coumarin, coumarin, ethylhexylglycerin, glycerin, phenoxyethanol, potassium hydroxide2024-11-29 10:47:42
Australian Gold Foaming Hand Soap Aloe Vera -- 7.5 fl ozAustralian GoldHousehold Essentialscitric acid, methylchloroisothiazolinone, benzyl alcohol, benzyl salicylate, citric acid, coumarin, coumarin, sodium laureth sulfate, glycerin, hexyl cinnamal, linalool, magnesium nitrate, propylene glycol, coco-betaine, sodium bicarbonate, sodium sulfate, triethylene glycol2024-11-29 10:47:42
Australian Gold Foaming Hand Soap Cocoa Dreams -- 7.5 fl ozAustralian GoldHousehold Essentialscitric acid, methylchloroisothiazolinone, benzyl alcohol, benzyl benzoate, citral, citric acid, coumarin, coumarin, sodium laureth sulfate, glycerin, limonene, linalool, magnesium nitrate, propylene glycol, coco-betaine, sodium benzoate, sodium bicarbonate, sodium sulfate, triethylene glycol2024-11-29 10:47:42
Australian Gold Liquid Hand Soap Cocoa Dreams -- 11.5 fl ozAustralian GoldHousehold Essentialscitric acid, methylchloroisothiazolinone, benzyl alcohol, citral, citric acid, cocamidopropyl betaine, coumarin, coumarin, sodium laureth sulfate, disodium EDTA, glycerin, limonene, linalool, magnesium nitrate, propylene glycol, sodium benzoate, sodium bicarbonate, sodium sulfate, triethylene glycol2024-11-29 10:47:42
Australian Gold Room Spray Cocoa Dreams -- 3.7 fl ozAustralian GoldHousehold Essentialscitric acid, benzyl alcohol, citral, citric acid, coumarin, coumarin, disodium EDTA, ethylhexylglycerin, glycerin, limonene, linalool, phenoxyethanol2024-11-29 10:47:42
Avalon Organics Bath & Shower Gel Nourishing Lavender -- 12 fl ozAvalon OrganicsBeauty & Personal CareGlyceryl Oleate, Citric Acid, Benzyl Alcohol, Bisabolol, Citric Acid, Coumarin, Coumarin, Decyl Glucoside, Limonene, Sodium Benzoate, Sodium Sulfate, Sorbitol2024-11-29 10:47:42
Avalon Organics Bath & Shower Gel Nourishing Lavender -- 32 fl ozAvalon OrganicsBeauty & Personal Carecitric acid, benzyl alcohol, bisabolol, citric acid, coumarin, coumarin, glycerin, limonene, sodium benzoate2024-11-29 10:47:42
Avalon Organics Conditioner Nourishing Lavender -- 11 fl ozAvalon OrganicsBeauty & Personal Carebenzyl alcohol, cetyl alcohol, coumarin, coumarin, limonene, sodium benzoate, sorbitol, stearic acid, stearyl alcohol2024-11-29 10:47:42
Avalon Organics Conditioner Nourishing Lavender -- 32 fl ozAvalon OrganicsBeauty & Personal Carebenzyl alcohol, cetyl alcohol, coumarin, coumarin, limonene, sodium benzoate, sorbitol, stearic acid, stearyl alcohol2024-11-29 10:47:42
Avalon Organics Hand & Body Lotion Lavender -- 12 fl ozAvalon OrganicsBeauty & Personal CareArginine, Benzyl Alcohol, Bisabolol, Cetyl Alcohol, Citral, Coumarin, Coumarin, Beta-Glucan, Geraniol, Glycerin, Limonene, Oat, Potassium Hydroxide, Sodium Benzoate, Stearic Acid, Stearyl Alcohol2024-11-29 10:47:42
Avalon Organics Hand & Body Lotion Lavender -- 32 fl ozAvalon OrganicsBeauty & Personal Carearginine, benzyl alcohol, bisabolol, cetyl alcohol, citral, coumarin, coumarin, beta-glucan, geraniol, glycerin, limonene, oat, potassium hydroxide, sodium benzoate, stearic acid, stearyl alcohol2024-11-29 10:47:42
Avalon Organics Shampoo Nourishing Lavender -- 11 fl ozAvalon OrganicsBeauty & Personal Careglyceryl oleate, citric acid, benzyl alcohol, bisabolol, citric acid, coumarin, coumarin, decyl glucoside, limonene, sodium benzoate, sodium sulfate, sorbitol2024-11-29 10:47:42
Avalon Organics Shampoo Nourishing Lavender -- 32 fl ozAvalon OrganicsBeauty & Personal Carecitric acid, benzyl alcohol, bisabolol, citric acid, coumarin, coumarin, limonene, sodium benzoate2024-11-29 10:47:42
Cantu Shea Butter for Natural Hair Define & Shine Custard -- 12 ozCantuBeauty & Personal Carecoumarin, coumarin, ethylhexylglycerin, glycerin2024-11-29 10:47:42
Cantu Shea Butter Leave-in Conditioning Repair Cream -- 16 ozCantuBeauty & Personal Careorange, citric acid, benzyl salicylate, propylene glycol dicaprylate/dicaprate, cetearyl alcohol, citric acid, coumarin, coumarin, cyclopentasiloxane, panthenol, dicetyldimonium chloride, disodium EDTA, ethylhexylglycerin, glycerin, dimethicone, hexyl cinnamal, hydroxyethylcellulose, butylphenyl methylpropional, limonene, phenoxyethanol, propylene glycol2024-11-29 10:47:42
Dead Sea Naturals Soothing Body Cream -- 6.8 fl ozDead Sea NaturalsBeauty & Personal Carecaprylyl glycol, allantoin, cetearyl alcohol, cetyl alcohol, chlorphenesin, cinnamyl alcohol, coumarin, coumarin, tocopherol, tocopherol, vitamin E, glyceryl stearate, glycerin, dimethicone, lactic acid, limonene, linalool, phenoxyethanol, PEG -40 stearate, propylene glycol, zinc oxide2024-11-29 10:47:42
Dead Sea Naturals Soothing Hand Cream -- 3.4 fl ozDead Sea NaturalsBeauty & Personal Carecaprylyl glycol, ascorbyl palmitate, allantoin, cetearyl alcohol, chlorphenesin, cinnamyl alcohol, coumarin, coumarin, tocopherol, tocopherol, vitamin E, glyceryl stearate, glycerin, dimethicone, lactic acid, limonene, linalool, phenoxyethanol, PEG-40 stearate, propylene glycol, beta-sitosterol, sodium lactate, squalene, stearyl alcohol, zinc oxide2024-11-29 10:47:42
Desert Essence Coconut Conditioner -- 8 fl ozDesert EssenceBeauty & Personal Carecitric acid, benzyl alcohol, benzyl benzoate, cetearyl alcohol, citric acid, coumarin, coumarin, dehydroacetic acid, glycerin, limonene2024-11-29 10:47:42
Desert Essence Coconut Shampoo -- 8 fl ozDesert EssenceBeauty & Personal Carecitric acid, benzyl alcohol, benzyl benzoate, citric acid, coumarin, coumarin, decyl glucoside, dehydroacetic acid, glycerin, hemp, limonene, propanediol2024-11-29 10:47:42
Desert Essence Nourishing Hand and Body Lotion Coconut -- 8 fl ozDesert EssenceBeauty & Personal Carebenzyl alcohol, benzyl benzoate, coumarin, coumarin, dehydroacetic acid, glycerin, limonene, stearic acid2024-11-29 10:47:42
ECOS Laundry Detergent Sheets HE Lavender Vanilla -- 50 LoadsECOSHousehold Essentialscitric acid, saponins, citric acid, cocamidopropyl betaine, coumarin, coumarin, triethyl citrate, glycerin, dimethicone, Kaolin, linalool, phenoxyethanol, propylene glycol, sodium citrate, sodium lauryl sulfate2024-11-29 10:47:42
ECOS Laundry Detergent Sheets HE Magnolia & Lily -- 50 LoadsECOSHousehold Essentialscitric acid, benzyl salicylate, saponins, citric acid, cocamidopropyl betaine, coumarin, coumarin, glycerin, dimethicone, hexyl cinnamal, Kaolin, phenoxyethanol, propylene glycol, sodium citrate, sodium lauryl sulfate2024-11-29 10:47:42
EOS Ultra Moisturizing Shave Cream Lavender -- 7 fl ozEOSBeauty & Personal Carecaprylyl glycol, citric acid, ascorbyl palmitate, carbomer, cetyl alcohol, citric acid, citronellol, coumarin, coumarin, disodium edta, geraniol, glycerin, dimethicone, hexylene glycol, limonene, phenoxyethanol, propylene glycol, sodium benzoate, sodium hydroxide, stearyl alcohol, titanium dioxide2024-11-29 10:47:42
Every Man Jack Body Wash and Shower Gel - Crimson Oak -- 16.9 fl ozEvery Man JackBeauty & Personal Carecitric acid, citric acid, lauramidopropyl betaine, coumarin, coumarin, ethylhexylglycerin, glycerin, linalool, trisodium ethylenediamine disuccinate, phenoxyethanol, sodium benzoate2024-11-29 10:47:42
Every Man Jack Deodorant Aluminum Free - Crimson Oak -- 2.7 ozEvery Man JackBeauty & Personal Carecaprylyl glycol, orange, alpha iso methyl ionone, cetyl alcohol, citronellal, coumarin, coumarin, Propanediol2024-11-29 10:47:42
GrabGreen Classic Dryer Sheets Vetiver -- 80 SheetsGrabGreenHousehold Essentialscellulose, coumarin, coumarin, hexyl cinnamal, hydroxyisohexyl 3-cyclohexene carboxaldehyde, butylphenyl methylpropional, limonene, linalool2024-11-29 10:47:42
Hempz Age Defying Body Moisturizer -- 17 fl ozHempzBeauty & Personal Carebutylene glycol, aminomethyl propanol, citric acid, alpha-isomethyl ionone, ascorbic acid, benzyl benzoate, caffeine, carbomer, cetyl alcohol, chlorphenesin, citric acid, coumarin, coumarin, tocopherol, disodium edta, ethylhexylglycerin, tocopherol, glyceryl stearate, glycerin, dimethicone, hexyl cinnamal, isopropyl palmitate, nylon-12, phenoxyethanol, propanediol, retinyl palmitate, sodium benzoate, sodium lactate, stearic acid, yellow 52024-11-29 10:47:42
Jason C Effects Powered By Ester-C Creme -- 2 ozJasonBeauty & Personal Careallantoin, alpha-isomethyl ionone, benzyl alcohol, benzyl benzoate, benzyl salicylate, gluconolactone, bisabolol, calcium ascorbate, cetearyl alcohol, cetyl alcohol, cinnamyl alcohol, citral, coumarin, coumarin, panthenol, glycerin, dimethicone, hexyl cinnamal, hydroxyisohexyl 3-cyclohexene carboxaldehyde, calcium carbonate, limonene, linalool, phenoxyethanol, potassium hydroxide, sodium benzoate, stearic acid, thioctic acid2024-11-29 10:47:42
Love Beauty and Planet Blooming Color Shampoo Bar Murumuru Butter & Rose -- 4 ozLove Beauty and PlanetBeauty & Personal Carealpha-isomethyl ionone, benzyl alcohol, benzyl salicylate, citronellol, coumarin, coumarin, hexyl cinnamal2024-11-29 10:47:42
Love Beauty and Planet Shea Butter & Sandalwood Hand Lotion -- 1 ozLove Beauty and PlanetBeauty & Personal CareCaprylyl Glycol, Coumarin, Coumarin, Dimethicone, Isopropyl Myristate, Phenoxyethanol2024-11-29 10:47:42
Love Beauty and Planet Soothe & Serene Argan Oil & Lavender Hand Lotion -- 1 fl ozLove Beauty and PlanetBeauty & Personal CareCaprylyl Glycol, BHT, Carbomer, Citronellol, Coumarin, Coumarin, Disodium EDTA, Hydroxycitronellal, Hydroxyethylcellulose, Limonene, Linalool, Phenoxyethanol, Triethanolamine2024-11-29 10:47:42
Love Beauty and Planet Sulfate-Free Smooth & Serene Argan Oil & Lavender Shampoo for Frizz Control -- 13.5 fl ozLove Beauty and PlanetBeauty & Personal Carecitric acid, citric acid, citronellol, coumarin, coumarin, sodium laureth sulfate, disodium EDTA, limonene, sodium benzoate2024-11-29 10:47:42
Method Dryer Sheets - Fresh Air -- 80 SheetsMethodHousehold Essentialscoumarin, coumarin, linalool2024-11-29 10:47:42
Petal Fresh Hair ResQ Thickening Follicle Stimulator Serum with Biotin -- 2 fl ozPetal FreshBeauty & Personal Carebenzyl salicylate, vitamin B7, caffeine, citronellol, coumarin, coumarin, tocopherol, panthenol, tocopherol, geraniol, vitamin E, glycerin, hexyl cinnamal, limonene, menthol, niacin, vitamin B5, vitamin B6, vitamin B62024-11-29 10:47:42
The Honey Pot Feminine Foaming Wash - Bergamot Rose -- 5.5 fl ozThe Honey PotBeauty & Personal Carecitric acid, benzyl salicylate, citral, citric acid, citronellol, cocamidopropyl betaine, coumarin, coumarin, tocopherol, ethylhexylglycerin, tocopherol, geraniol, glycerin, hexyl cinnamal, hydroxycitronellal, lactic acid, limonene, linalool, phenoxyethanol, propylene glycol, sodium benzoate2024-11-29 10:47:42

Protein Targets (63)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Chain A, Breast cancer type 1 susceptibility proteinHomo sapiens (human)Potency0.12591.258920.440939.8107AID875
Chain A, Ferritin light chainEquus caballus (horse)Potency25.11895.623417.292931.6228AID485281
LuciferasePhotinus pyralis (common eastern firefly)Potency0.05770.007215.758889.3584AID411; AID588342
ATAD5 protein, partialHomo sapiens (human)Potency0.16470.004110.890331.5287AID504466; AID504467
USP1 protein, partialHomo sapiens (human)Potency1.25890.031637.5844354.8130AID743255
GLS proteinHomo sapiens (human)Potency12.58930.35487.935539.8107AID624170
TDP1 proteinHomo sapiens (human)Potency9.20000.000811.382244.6684AID686978; AID686979
Microtubule-associated protein tauHomo sapiens (human)Potency1.58490.180013.557439.8107AID1460
Smad3Homo sapiens (human)Potency0.70790.00527.809829.0929AID588855
apical membrane antigen 1, AMA1Plasmodium falciparum 3D7Potency6.30960.707912.194339.8107AID720542
PINK1Homo sapiens (human)Potency1.77832.818418.895944.6684AID624263
luciferasePhoturis pensylvanica (Pennsylania firefly)Potency10.00000.891310.432820.5750AID1379
ParkinHomo sapiens (human)Potency1.77830.819914.830644.6684AID624263
serine-protein kinase ATM isoform aHomo sapiens (human)Potency14.24380.707925.111941.2351AID485349; AID493185; AID493218
NPC intracellular cholesterol transporter 1 precursorHomo sapiens (human)Potency0.28180.01262.451825.0177AID485313
hemoglobin subunit betaHomo sapiens (human)Potency0.79430.31629.086131.6228AID925
cellular tumor antigen p53 isoform aHomo sapiens (human)Potency0.35710.316212.443531.6228AID902; AID924
chromobox protein homolog 1Homo sapiens (human)Potency12.58930.006026.168889.1251AID540317
huntingtin isoform 2Homo sapiens (human)Potency0.31620.000618.41981,122.0200AID1688
importin subunit beta-1 isoform 1Homo sapiens (human)Potency3.57175.804836.130665.1308AID540253; AID540263
DNA polymerase betaHomo sapiens (human)Potency100.00000.022421.010289.1251AID485314
ubiquitin carboxyl-terminal hydrolase 2 isoform aHomo sapiens (human)Potency0.43010.65619.452025.1189AID463254; AID927
ras-related protein Rab-9AHomo sapiens (human)Potency0.10000.00022.621531.4954AID485297
serine/threonine-protein kinase PLK1Homo sapiens (human)Potency26.67950.168316.404067.0158AID720504
eyes absent homolog 2 isoform aHomo sapiens (human)Potency2.51191.199814.641950.1187AID488837
snurportin-1Homo sapiens (human)Potency3.57175.804836.130665.1308AID540253; AID540263
histone-lysine N-methyltransferase 2A isoform 2 precursorHomo sapiens (human)Potency0.44670.010323.856763.0957AID2662
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1Homo sapiens (human)Potency15.10140.425612.059128.1838AID504891
tumor susceptibility gene 101 proteinHomo sapiens (human)Potency15.84890.129810.833132.6090AID493005
GTP-binding nuclear protein Ran isoform 1Homo sapiens (human)Potency3.98115.804816.996225.9290AID540253
DNA polymerase eta isoform 1Homo sapiens (human)Potency7.07950.100028.9256213.3130AID588591
DNA polymerase iota isoform a (long)Homo sapiens (human)Potency100.00000.050127.073689.1251AID588590
nuclear receptor ROR-gamma isoform 1Mus musculus (house mouse)Potency5.58100.00798.23321,122.0200AID2551; AID2762; AID2763
gemininHomo sapiens (human)Potency4.64150.004611.374133.4983AID624296; AID624297
muscleblind-like protein 1 isoform 1Homo sapiens (human)Potency7.07950.00419.962528.1838AID2675
DNA dC->dU-editing enzyme APOBEC-3G isoform 1Homo sapiens (human)Potency3.54810.058010.694926.6086AID602310
caspase-1 isoform alpha precursorHomo sapiens (human)Potency0.15850.000311.448431.6228AID900
lethal factor (plasmid)Bacillus anthracis str. A2012Potency1.58490.020010.786931.6228AID912
lamin isoform A-delta10Homo sapiens (human)Potency1.12200.891312.067628.1838AID1487
neuropeptide S receptor isoform AHomo sapiens (human)Potency12.58930.015812.3113615.5000AID1461
Rap guanine nucleotide exchange factor 3Homo sapiens (human)Potency64.35526.309660.2008112.2020AID720707; AID720709
Glycoprotein hormones alpha chainHomo sapiens (human)Potency2.23874.46688.344810.0000AID624291
Integrin beta-3Homo sapiens (human)Potency0.31620.316211.415731.6228AID924
Integrin alpha-IIbHomo sapiens (human)Potency0.31620.316211.415731.6228AID924
Caspase-7Homo sapiens (human)Potency0.15853.981118.585631.6228AID889
Disintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)Potency0.19951.584913.004325.1189AID927
Rap guanine nucleotide exchange factor 4Homo sapiens (human)Potency89.12513.981146.7448112.2020AID720708
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
metallo beta-lactamasePseudomonas aeruginosaIC50 (µMol)2.72800.03392.91006.2480AID2754
Mcl-1Homo sapiens (human)IC50 (µMol)1.62000.40007.134454.0000AID1418
PTK2B protein tyrosine kinase 2 betaHomo sapiens (human)IC50 (µMol)2.32401.53704.08056.9220AID1641
Valosin-containing proteinHomo sapiens (human)IC50 (µMol)1.40000.11006.018728.0000AID488828
metallo-beta-lactamase IMP-1Pseudomonas aeruginosaIC50 (µMol)3.24103.24105.96858.6960AID2756
Muscarinic acetylcholine receptor M1Rattus norvegicus (Norway rat)IC50 (µMol)1.62000.00052.773925.1700AID1418
Muscarinic acetylcholine receptor M3Rattus norvegicus (Norway rat)IC50 (µMol)1.62000.00052.891925.1700AID1418
Muscarinic acetylcholine receptor M4Rattus norvegicus (Norway rat)IC50 (µMol)1.62000.00052.747825.1700AID1418
Luciferin 4-monooxygenasePhotinus pyralis (common eastern firefly)IC50 (µMol)3.02800.05893.142610.0000AID328181; AID328182; AID328183; AID328185; AID328186
Muscarinic acetylcholine receptor M5Rattus norvegicus (Norway rat)IC50 (µMol)1.62000.00052.780225.1700AID1418
Muscarinic acetylcholine receptor M2Rattus norvegicus (Norway rat)IC50 (µMol)1.62000.00053.314249.5000AID1418
B1 bradykinin receptorHomo sapiens (human)IC50 (µMol)3.24100.00091.62093.2410AID2756
Beta lactamase (plasmid)Pseudomonas aeruginosaIC50 (µMol)0.70910.70915.05497.7510AID2755
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Activation Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
matrix metalloproteinase 1, partialHomo sapiens (human)EC50 (µMol)1.06001.060010.759427.6000AID618
voltage-dependent T-type calcium channel subunit alpha-1H isoform aHomo sapiens (human)EC50 (µMol)0.43400.43404.827513.3000AID489005
ORF73Human gammaherpesvirus 8EC50 (µMol)75.00000.06008.134632.1400AID435023
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (163)

Processvia Protein(s)Taxonomy
angiogenesisRap guanine nucleotide exchange factor 3Homo sapiens (human)
adaptive immune responseRap guanine nucleotide exchange factor 3Homo sapiens (human)
signal transductionRap guanine nucleotide exchange factor 3Homo sapiens (human)
adenylate cyclase-activating G protein-coupled receptor signaling pathwayRap guanine nucleotide exchange factor 3Homo sapiens (human)
associative learningRap guanine nucleotide exchange factor 3Homo sapiens (human)
Rap protein signal transductionRap guanine nucleotide exchange factor 3Homo sapiens (human)
regulation of actin cytoskeleton organizationRap guanine nucleotide exchange factor 3Homo sapiens (human)
negative regulation of syncytium formation by plasma membrane fusionRap guanine nucleotide exchange factor 3Homo sapiens (human)
intracellular signal transductionRap guanine nucleotide exchange factor 3Homo sapiens (human)
positive regulation of GTPase activityRap guanine nucleotide exchange factor 3Homo sapiens (human)
regulation of angiogenesisRap guanine nucleotide exchange factor 3Homo sapiens (human)
positive regulation of angiogenesisRap guanine nucleotide exchange factor 3Homo sapiens (human)
positive regulation of protein export from nucleusRap guanine nucleotide exchange factor 3Homo sapiens (human)
positive regulation of stress fiber assemblyRap guanine nucleotide exchange factor 3Homo sapiens (human)
regulation of phosphatidylinositol 3-kinase/protein kinase B signal transductionRap guanine nucleotide exchange factor 3Homo sapiens (human)
positive regulation of syncytium formation by plasma membrane fusionRap guanine nucleotide exchange factor 3Homo sapiens (human)
establishment of endothelial barrierRap guanine nucleotide exchange factor 3Homo sapiens (human)
cellular response to cAMPRap guanine nucleotide exchange factor 3Homo sapiens (human)
Ras protein signal transductionRap guanine nucleotide exchange factor 3Homo sapiens (human)
regulation of insulin secretionRap guanine nucleotide exchange factor 3Homo sapiens (human)
G protein-coupled receptor signaling pathwayGlycoprotein hormones alpha chainHomo sapiens (human)
positive regulation of cell population proliferationGlycoprotein hormones alpha chainHomo sapiens (human)
hormone-mediated signaling pathwayGlycoprotein hormones alpha chainHomo sapiens (human)
regulation of signaling receptor activityGlycoprotein hormones alpha chainHomo sapiens (human)
positive regulation of steroid biosynthetic processGlycoprotein hormones alpha chainHomo sapiens (human)
positive regulation of cell migrationGlycoprotein hormones alpha chainHomo sapiens (human)
thyroid gland developmentGlycoprotein hormones alpha chainHomo sapiens (human)
luteinizing hormone secretionGlycoprotein hormones alpha chainHomo sapiens (human)
organ growthGlycoprotein hormones alpha chainHomo sapiens (human)
follicle-stimulating hormone signaling pathwayGlycoprotein hormones alpha chainHomo sapiens (human)
positive regulation of transcription by RNA polymerase IIGlycoprotein hormones alpha chainHomo sapiens (human)
negative regulation of organ growthGlycoprotein hormones alpha chainHomo sapiens (human)
follicle-stimulating hormone secretionGlycoprotein hormones alpha chainHomo sapiens (human)
thyroid hormone generationGlycoprotein hormones alpha chainHomo sapiens (human)
negative regulation of low-density lipoprotein receptor activityIntegrin beta-3Homo sapiens (human)
positive regulation of protein phosphorylationIntegrin beta-3Homo sapiens (human)
positive regulation of endothelial cell proliferationIntegrin beta-3Homo sapiens (human)
positive regulation of cell-matrix adhesionIntegrin beta-3Homo sapiens (human)
cell-substrate junction assemblyIntegrin beta-3Homo sapiens (human)
cell adhesionIntegrin beta-3Homo sapiens (human)
cell-matrix adhesionIntegrin beta-3Homo sapiens (human)
integrin-mediated signaling pathwayIntegrin beta-3Homo sapiens (human)
embryo implantationIntegrin beta-3Homo sapiens (human)
blood coagulationIntegrin beta-3Homo sapiens (human)
positive regulation of endothelial cell migrationIntegrin beta-3Homo sapiens (human)
positive regulation of gene expressionIntegrin beta-3Homo sapiens (human)
negative regulation of macrophage derived foam cell differentiationIntegrin beta-3Homo sapiens (human)
positive regulation of fibroblast migrationIntegrin beta-3Homo sapiens (human)
negative regulation of lipid storageIntegrin beta-3Homo sapiens (human)
response to activityIntegrin beta-3Homo sapiens (human)
smooth muscle cell migrationIntegrin beta-3Homo sapiens (human)
positive regulation of smooth muscle cell migrationIntegrin beta-3Homo sapiens (human)
platelet activationIntegrin beta-3Homo sapiens (human)
positive regulation of vascular endothelial growth factor receptor signaling pathwayIntegrin beta-3Homo sapiens (human)
cell-substrate adhesionIntegrin beta-3Homo sapiens (human)
activation of protein kinase activityIntegrin beta-3Homo sapiens (human)
negative regulation of lipid transportIntegrin beta-3Homo sapiens (human)
regulation of protein localizationIntegrin beta-3Homo sapiens (human)
regulation of actin cytoskeleton organizationIntegrin beta-3Homo sapiens (human)
cell adhesion mediated by integrinIntegrin beta-3Homo sapiens (human)
positive regulation of cell adhesion mediated by integrinIntegrin beta-3Homo sapiens (human)
positive regulation of osteoblast proliferationIntegrin beta-3Homo sapiens (human)
heterotypic cell-cell adhesionIntegrin beta-3Homo sapiens (human)
substrate adhesion-dependent cell spreadingIntegrin beta-3Homo sapiens (human)
tube developmentIntegrin beta-3Homo sapiens (human)
wound healing, spreading of epidermal cellsIntegrin beta-3Homo sapiens (human)
cellular response to platelet-derived growth factor stimulusIntegrin beta-3Homo sapiens (human)
apolipoprotein A-I-mediated signaling pathwayIntegrin beta-3Homo sapiens (human)
wound healingIntegrin beta-3Homo sapiens (human)
apoptotic cell clearanceIntegrin beta-3Homo sapiens (human)
regulation of bone resorptionIntegrin beta-3Homo sapiens (human)
positive regulation of angiogenesisIntegrin beta-3Homo sapiens (human)
positive regulation of bone resorptionIntegrin beta-3Homo sapiens (human)
symbiont entry into host cellIntegrin beta-3Homo sapiens (human)
platelet-derived growth factor receptor signaling pathwayIntegrin beta-3Homo sapiens (human)
positive regulation of fibroblast proliferationIntegrin beta-3Homo sapiens (human)
mesodermal cell differentiationIntegrin beta-3Homo sapiens (human)
positive regulation of smooth muscle cell proliferationIntegrin beta-3Homo sapiens (human)
positive regulation of peptidyl-tyrosine phosphorylationIntegrin beta-3Homo sapiens (human)
negative regulation of lipoprotein metabolic processIntegrin beta-3Homo sapiens (human)
negative chemotaxisIntegrin beta-3Homo sapiens (human)
regulation of release of sequestered calcium ion into cytosolIntegrin beta-3Homo sapiens (human)
regulation of serotonin uptakeIntegrin beta-3Homo sapiens (human)
angiogenesis involved in wound healingIntegrin beta-3Homo sapiens (human)
positive regulation of ERK1 and ERK2 cascadeIntegrin beta-3Homo sapiens (human)
platelet aggregationIntegrin beta-3Homo sapiens (human)
cellular response to mechanical stimulusIntegrin beta-3Homo sapiens (human)
cellular response to xenobiotic stimulusIntegrin beta-3Homo sapiens (human)
positive regulation of glomerular mesangial cell proliferationIntegrin beta-3Homo sapiens (human)
blood coagulation, fibrin clot formationIntegrin beta-3Homo sapiens (human)
maintenance of postsynaptic specialization structureIntegrin beta-3Homo sapiens (human)
regulation of postsynaptic neurotransmitter receptor internalizationIntegrin beta-3Homo sapiens (human)
regulation of postsynaptic neurotransmitter receptor diffusion trappingIntegrin beta-3Homo sapiens (human)
positive regulation of substrate adhesion-dependent cell spreadingIntegrin beta-3Homo sapiens (human)
positive regulation of adenylate cyclase-inhibiting opioid receptor signaling pathwayIntegrin beta-3Homo sapiens (human)
regulation of trophoblast cell migrationIntegrin beta-3Homo sapiens (human)
regulation of extracellular matrix organizationIntegrin beta-3Homo sapiens (human)
cellular response to insulin-like growth factor stimulusIntegrin beta-3Homo sapiens (human)
negative regulation of endothelial cell apoptotic processIntegrin beta-3Homo sapiens (human)
positive regulation of T cell migrationIntegrin beta-3Homo sapiens (human)
cell migrationIntegrin beta-3Homo sapiens (human)
positive regulation of leukocyte migrationIntegrin alpha-IIbHomo sapiens (human)
cell-matrix adhesionIntegrin alpha-IIbHomo sapiens (human)
integrin-mediated signaling pathwayIntegrin alpha-IIbHomo sapiens (human)
angiogenesisIntegrin alpha-IIbHomo sapiens (human)
cell-cell adhesionIntegrin alpha-IIbHomo sapiens (human)
cell adhesion mediated by integrinIntegrin alpha-IIbHomo sapiens (human)
negative regulation of protein phosphorylationB1 bradykinin receptorHomo sapiens (human)
positive regulation of leukocyte migrationB1 bradykinin receptorHomo sapiens (human)
inflammatory responseB1 bradykinin receptorHomo sapiens (human)
positive regulation of cytosolic calcium ion concentrationB1 bradykinin receptorHomo sapiens (human)
protein kinase C-activating G protein-coupled receptor signaling pathwayB1 bradykinin receptorHomo sapiens (human)
response to mechanical stimulusB1 bradykinin receptorHomo sapiens (human)
cell migrationB1 bradykinin receptorHomo sapiens (human)
negative regulation of cell growthB1 bradykinin receptorHomo sapiens (human)
response to lipopolysaccharideB1 bradykinin receptorHomo sapiens (human)
negative regulation of blood pressureB1 bradykinin receptorHomo sapiens (human)
positive regulation of release of sequestered calcium ion into cytosolB1 bradykinin receptorHomo sapiens (human)
G protein-coupled receptor signaling pathwayB1 bradykinin receptorHomo sapiens (human)
proteolysisCaspase-7Homo sapiens (human)
apoptotic processCaspase-7Homo sapiens (human)
heart developmentCaspase-7Homo sapiens (human)
response to UVCaspase-7Homo sapiens (human)
protein processingCaspase-7Homo sapiens (human)
protein catabolic processCaspase-7Homo sapiens (human)
defense response to bacteriumCaspase-7Homo sapiens (human)
fibroblast apoptotic processCaspase-7Homo sapiens (human)
striated muscle cell differentiationCaspase-7Homo sapiens (human)
neuron apoptotic processCaspase-7Homo sapiens (human)
protein maturationCaspase-7Homo sapiens (human)
lymphocyte apoptotic processCaspase-7Homo sapiens (human)
cellular response to lipopolysaccharideCaspase-7Homo sapiens (human)
cellular response to staurosporineCaspase-7Homo sapiens (human)
execution phase of apoptosisCaspase-7Homo sapiens (human)
positive regulation of plasma membrane repairCaspase-7Homo sapiens (human)
positive regulation of neuron apoptotic processCaspase-7Homo sapiens (human)
positive regulation of epidermal growth factor receptor signaling pathwayDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
response to hypoxiaDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
neutrophil mediated immunityDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
germinal center formationDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
positive regulation of leukocyte chemotaxisDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
proteolysisDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
membrane protein ectodomain proteolysisDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
cell adhesionDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
Notch receptor processingDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
positive regulation of cell population proliferationDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
response to xenobiotic stimulusDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
positive regulation of T cell chemotaxisDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
protein processingDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
signal releaseDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
B cell differentiationDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
positive regulation of cell growthDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
positive regulation of cell migrationDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
negative regulation of transforming growth factor beta receptor signaling pathwayDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
response to lipopolysaccharideDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
positive regulation of chemokine productionDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
positive regulation of tumor necrosis factor productionDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
regulation of mast cell apoptotic processDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
T cell differentiation in thymusDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
cell adhesion mediated by integrinDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
wound healing, spreading of epidermal cellsDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
amyloid precursor protein catabolic processDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
positive regulation of blood vessel endothelial cell migrationDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
positive regulation of cyclin-dependent protein serine/threonine kinase activityDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
positive regulation of epidermal growth factor-activated receptor activityDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
positive regulation of epidermal growth factor receptor signaling pathwayDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
spleen developmentDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
cell motilityDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
defense response to Gram-positive bacteriumDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
cellular response to high density lipoprotein particle stimulusDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
commissural neuron axon guidanceDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
negative regulation of cold-induced thermogenesisDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
positive regulation of G1/S transition of mitotic cell cycleDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
positive regulation of tumor necrosis factor-mediated signaling pathwayDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
positive regulation of vascular endothelial cell proliferationDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
Notch signaling pathwayDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
adaptive immune responseRap guanine nucleotide exchange factor 4Homo sapiens (human)
G protein-coupled receptor signaling pathwayRap guanine nucleotide exchange factor 4Homo sapiens (human)
adenylate cyclase-activating G protein-coupled receptor signaling pathwayRap guanine nucleotide exchange factor 4Homo sapiens (human)
calcium-ion regulated exocytosisRap guanine nucleotide exchange factor 4Homo sapiens (human)
regulation of exocytosisRap guanine nucleotide exchange factor 4Homo sapiens (human)
insulin secretionRap guanine nucleotide exchange factor 4Homo sapiens (human)
positive regulation of insulin secretionRap guanine nucleotide exchange factor 4Homo sapiens (human)
regulation of synaptic vesicle cycleRap guanine nucleotide exchange factor 4Homo sapiens (human)
Ras protein signal transductionRap guanine nucleotide exchange factor 4Homo sapiens (human)
regulation of insulin secretionRap guanine nucleotide exchange factor 4Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (47)

Processvia Protein(s)Taxonomy
guanyl-nucleotide exchange factor activityRap guanine nucleotide exchange factor 3Homo sapiens (human)
protein bindingRap guanine nucleotide exchange factor 3Homo sapiens (human)
protein domain specific bindingRap guanine nucleotide exchange factor 3Homo sapiens (human)
cAMP bindingRap guanine nucleotide exchange factor 3Homo sapiens (human)
hormone activityGlycoprotein hormones alpha chainHomo sapiens (human)
protein bindingGlycoprotein hormones alpha chainHomo sapiens (human)
follicle-stimulating hormone activityGlycoprotein hormones alpha chainHomo sapiens (human)
fibroblast growth factor bindingIntegrin beta-3Homo sapiens (human)
C-X3-C chemokine bindingIntegrin beta-3Homo sapiens (human)
insulin-like growth factor I bindingIntegrin beta-3Homo sapiens (human)
neuregulin bindingIntegrin beta-3Homo sapiens (human)
virus receptor activityIntegrin beta-3Homo sapiens (human)
fibronectin bindingIntegrin beta-3Homo sapiens (human)
protease bindingIntegrin beta-3Homo sapiens (human)
protein disulfide isomerase activityIntegrin beta-3Homo sapiens (human)
protein kinase C bindingIntegrin beta-3Homo sapiens (human)
platelet-derived growth factor receptor bindingIntegrin beta-3Homo sapiens (human)
integrin bindingIntegrin beta-3Homo sapiens (human)
protein bindingIntegrin beta-3Homo sapiens (human)
coreceptor activityIntegrin beta-3Homo sapiens (human)
enzyme bindingIntegrin beta-3Homo sapiens (human)
identical protein bindingIntegrin beta-3Homo sapiens (human)
vascular endothelial growth factor receptor 2 bindingIntegrin beta-3Homo sapiens (human)
metal ion bindingIntegrin beta-3Homo sapiens (human)
cell adhesion molecule bindingIntegrin beta-3Homo sapiens (human)
extracellular matrix bindingIntegrin beta-3Homo sapiens (human)
fibrinogen bindingIntegrin beta-3Homo sapiens (human)
protein bindingIntegrin alpha-IIbHomo sapiens (human)
identical protein bindingIntegrin alpha-IIbHomo sapiens (human)
metal ion bindingIntegrin alpha-IIbHomo sapiens (human)
extracellular matrix bindingIntegrin alpha-IIbHomo sapiens (human)
molecular adaptor activityIntegrin alpha-IIbHomo sapiens (human)
fibrinogen bindingIntegrin alpha-IIbHomo sapiens (human)
integrin bindingIntegrin alpha-IIbHomo sapiens (human)
bradykinin receptor activityB1 bradykinin receptorHomo sapiens (human)
protein bindingB1 bradykinin receptorHomo sapiens (human)
peptide bindingB1 bradykinin receptorHomo sapiens (human)
RNA bindingCaspase-7Homo sapiens (human)
aspartic-type endopeptidase activityCaspase-7Homo sapiens (human)
cysteine-type endopeptidase activityCaspase-7Homo sapiens (human)
protein bindingCaspase-7Homo sapiens (human)
peptidase activityCaspase-7Homo sapiens (human)
cysteine-type peptidase activityCaspase-7Homo sapiens (human)
cysteine-type endopeptidase activity involved in apoptotic processCaspase-7Homo sapiens (human)
cysteine-type endopeptidase activity involved in execution phase of apoptosisCaspase-7Homo sapiens (human)
endopeptidase activityDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
metalloendopeptidase activityDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
Notch bindingDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
interleukin-6 receptor bindingDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
integrin bindingDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
protein bindingDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
peptidase activityDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
metallopeptidase activityDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
SH3 domain bindingDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
cytokine bindingDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
PDZ domain bindingDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
tumor necrosis factor bindingDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
metal ion bindingDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
metalloendopeptidase activity involved in amyloid precursor protein catabolic processDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
guanyl-nucleotide exchange factor activityRap guanine nucleotide exchange factor 4Homo sapiens (human)
protein bindingRap guanine nucleotide exchange factor 4Homo sapiens (human)
cAMP bindingRap guanine nucleotide exchange factor 4Homo sapiens (human)
protein-macromolecule adaptor activityRap guanine nucleotide exchange factor 4Homo sapiens (human)
small GTPase bindingRap guanine nucleotide exchange factor 4Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (49)

Processvia Protein(s)Taxonomy
plasma membraneRap guanine nucleotide exchange factor 3Homo sapiens (human)
cortical actin cytoskeletonRap guanine nucleotide exchange factor 3Homo sapiens (human)
plasma membraneRap guanine nucleotide exchange factor 3Homo sapiens (human)
microvillusRap guanine nucleotide exchange factor 3Homo sapiens (human)
endomembrane systemRap guanine nucleotide exchange factor 3Homo sapiens (human)
membraneRap guanine nucleotide exchange factor 3Homo sapiens (human)
lamellipodiumRap guanine nucleotide exchange factor 3Homo sapiens (human)
filopodiumRap guanine nucleotide exchange factor 3Homo sapiens (human)
extracellular exosomeRap guanine nucleotide exchange factor 3Homo sapiens (human)
extracellular regionGlycoprotein hormones alpha chainHomo sapiens (human)
extracellular spaceGlycoprotein hormones alpha chainHomo sapiens (human)
Golgi lumenGlycoprotein hormones alpha chainHomo sapiens (human)
follicle-stimulating hormone complexGlycoprotein hormones alpha chainHomo sapiens (human)
pituitary gonadotropin complexGlycoprotein hormones alpha chainHomo sapiens (human)
extracellular spaceGlycoprotein hormones alpha chainHomo sapiens (human)
glutamatergic synapseIntegrin beta-3Homo sapiens (human)
nucleusIntegrin beta-3Homo sapiens (human)
nucleoplasmIntegrin beta-3Homo sapiens (human)
plasma membraneIntegrin beta-3Homo sapiens (human)
cell-cell junctionIntegrin beta-3Homo sapiens (human)
focal adhesionIntegrin beta-3Homo sapiens (human)
external side of plasma membraneIntegrin beta-3Homo sapiens (human)
cell surfaceIntegrin beta-3Homo sapiens (human)
apical plasma membraneIntegrin beta-3Homo sapiens (human)
platelet alpha granule membraneIntegrin beta-3Homo sapiens (human)
lamellipodium membraneIntegrin beta-3Homo sapiens (human)
filopodium membraneIntegrin beta-3Homo sapiens (human)
microvillus membraneIntegrin beta-3Homo sapiens (human)
ruffle membraneIntegrin beta-3Homo sapiens (human)
integrin alphav-beta3 complexIntegrin beta-3Homo sapiens (human)
melanosomeIntegrin beta-3Homo sapiens (human)
synapseIntegrin beta-3Homo sapiens (human)
postsynaptic membraneIntegrin beta-3Homo sapiens (human)
extracellular exosomeIntegrin beta-3Homo sapiens (human)
integrin alphaIIb-beta3 complexIntegrin beta-3Homo sapiens (human)
glycinergic synapseIntegrin beta-3Homo sapiens (human)
integrin complexIntegrin beta-3Homo sapiens (human)
protein-containing complexIntegrin beta-3Homo sapiens (human)
alphav-beta3 integrin-PKCalpha complexIntegrin beta-3Homo sapiens (human)
alphav-beta3 integrin-IGF-1-IGF1R complexIntegrin beta-3Homo sapiens (human)
alphav-beta3 integrin-HMGB1 complexIntegrin beta-3Homo sapiens (human)
receptor complexIntegrin beta-3Homo sapiens (human)
alphav-beta3 integrin-vitronectin complexIntegrin beta-3Homo sapiens (human)
alpha9-beta1 integrin-ADAM8 complexIntegrin beta-3Homo sapiens (human)
focal adhesionIntegrin beta-3Homo sapiens (human)
cell surfaceIntegrin beta-3Homo sapiens (human)
synapseIntegrin beta-3Homo sapiens (human)
plasma membraneIntegrin alpha-IIbHomo sapiens (human)
focal adhesionIntegrin alpha-IIbHomo sapiens (human)
cell surfaceIntegrin alpha-IIbHomo sapiens (human)
platelet alpha granule membraneIntegrin alpha-IIbHomo sapiens (human)
extracellular exosomeIntegrin alpha-IIbHomo sapiens (human)
integrin alphaIIb-beta3 complexIntegrin alpha-IIbHomo sapiens (human)
blood microparticleIntegrin alpha-IIbHomo sapiens (human)
integrin complexIntegrin alpha-IIbHomo sapiens (human)
external side of plasma membraneIntegrin alpha-IIbHomo sapiens (human)
endoplasmic reticulumB1 bradykinin receptorHomo sapiens (human)
plasma membraneB1 bradykinin receptorHomo sapiens (human)
plasma membraneB1 bradykinin receptorHomo sapiens (human)
extracellular spaceCaspase-7Homo sapiens (human)
nucleusCaspase-7Homo sapiens (human)
cytoplasmCaspase-7Homo sapiens (human)
cytosolCaspase-7Homo sapiens (human)
nucleusCaspase-7Homo sapiens (human)
nucleoplasmCaspase-7Homo sapiens (human)
cytosolCaspase-7Homo sapiens (human)
cell-cell junctionDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
focal adhesionDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
ruffle membraneDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
Golgi membraneDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
cytoplasmDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
endoplasmic reticulum lumenDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
cytosolDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
plasma membraneDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
cell surfaceDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
actin cytoskeletonDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
membraneDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
apical plasma membraneDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
membrane raftDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
plasma membraneDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
cytosolRap guanine nucleotide exchange factor 4Homo sapiens (human)
plasma membraneRap guanine nucleotide exchange factor 4Homo sapiens (human)
membraneRap guanine nucleotide exchange factor 4Homo sapiens (human)
hippocampal mossy fiber to CA3 synapseRap guanine nucleotide exchange factor 4Homo sapiens (human)
plasma membraneRap guanine nucleotide exchange factor 4Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (32)

Assay IDTitleYearJournalArticle
AID1198908Inhibition of full-length X4 tropic HIV-1 clone pNL4-3 Vif/human APOBEC3G complex transfected in human 293T cells measured at 50 uM after 48 hrs by GFP-based fluorescence assay relative to control2015European journal of medicinal chemistry, May-05, Volume: 95Development of benzimidazole derivatives to inhibit HIV-1 replication through protecting APOBEC3G protein.
AID270397Antiproliferative activity against human U87 MG cell line2006Bioorganic & medicinal chemistry letters, Sep-01, Volume: 16, Issue:17
Synthesis and anti-angiogenesis activity of coumarin derivatives.
AID328181Inhibition of Photinus pyralis luciferase by PK-Light assay2008Journal of medicinal chemistry, Apr-24, Volume: 51, Issue:8
Characterization of chemical libraries for luciferase inhibitory activity.
AID270401Antiproliferative activity against human SiHa cell line2006Bioorganic & medicinal chemistry letters, Sep-01, Volume: 16, Issue:17
Synthesis and anti-angiogenesis activity of coumarin derivatives.
AID328184Inhibition of luciferase Photuris pennsylvanica by Promega Kinase-Glo assay2008Journal of medicinal chemistry, Apr-24, Volume: 51, Issue:8
Characterization of chemical libraries for luciferase inhibitory activity.
AID270398Antiproliferative activity against mouse B16 cell line2006Bioorganic & medicinal chemistry letters, Sep-01, Volume: 16, Issue:17
Synthesis and anti-angiogenesis activity of coumarin derivatives.
AID328183Inhibition of Photinus pyralis luciferase by Easy lite assay2008Journal of medicinal chemistry, Apr-24, Volume: 51, Issue:8
Characterization of chemical libraries for luciferase inhibitory activity.
AID328187Inhibition of Renilla reniformis luciferase2008Journal of medicinal chemistry, Apr-24, Volume: 51, Issue:8
Characterization of chemical libraries for luciferase inhibitory activity.
AID270400Antiproliferative activity against human DLD1 cell line2006Bioorganic & medicinal chemistry letters, Sep-01, Volume: 16, Issue:17
Synthesis and anti-angiogenesis activity of coumarin derivatives.
AID328185Inhibition of Photinus pyralis luciferase by Steady-Glo reporter gene assay2008Journal of medicinal chemistry, Apr-24, Volume: 51, Issue:8
Characterization of chemical libraries for luciferase inhibitory activity.
AID270402Antiproliferative activity against mouse NIH3T3 cell line2006Bioorganic & medicinal chemistry letters, Sep-01, Volume: 16, Issue:17
Synthesis and anti-angiogenesis activity of coumarin derivatives.
AID328186Inhibition of Photinus pyralis luciferase by BrightGlo reporter gene assay2008Journal of medicinal chemistry, Apr-24, Volume: 51, Issue:8
Characterization of chemical libraries for luciferase inhibitory activity.
AID270403Antiproliferative activity against HUVEC cell line2006Bioorganic & medicinal chemistry letters, Sep-01, Volume: 16, Issue:17
Synthesis and anti-angiogenesis activity of coumarin derivatives.
AID1198909Antiviral activity against X4 tropic HIV-1 clone pNL4-3 infected in H9 cells assessed as reduction in p24 antigen after 4 days by ELISA2015European journal of medicinal chemistry, May-05, Volume: 95Development of benzimidazole derivatives to inhibit HIV-1 replication through protecting APOBEC3G protein.
AID1198930Cytotoxicity against human H9 cells by MTS assay2015European journal of medicinal chemistry, May-05, Volume: 95Development of benzimidazole derivatives to inhibit HIV-1 replication through protecting APOBEC3G protein.
AID328188Inhibition of Photinus pyralis luciferase at 0.04 uM2008Journal of medicinal chemistry, Apr-24, Volume: 51, Issue:8
Characterization of chemical libraries for luciferase inhibitory activity.
AID328182Inhibition of Photinus pyralis luciferase2008Journal of medicinal chemistry, Apr-24, Volume: 51, Issue:8
Characterization of chemical libraries for luciferase inhibitory activity.
AID270399Antiproliferative activity against human HeLa cell line2006Bioorganic & medicinal chemistry letters, Sep-01, Volume: 16, Issue:17
Synthesis and anti-angiogenesis activity of coumarin derivatives.
AID651635Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression
AID504812Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign2010Endocrinology, Jul, Volume: 151, Issue:7
A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID1745845Primary qHTS for Inhibitors of ATXN expression
AID504810Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign2010Endocrinology, Jul, Volume: 151, Issue:7
A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID588519A screen for compounds that inhibit viral RNA polymerase binding and polymerization activities2011Antiviral research, Sep, Volume: 91, Issue:3
High-throughput screening identification of poliovirus RNA-dependent RNA polymerase inhibitors.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (30)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's8 (26.67)29.6817
2010's19 (63.33)24.3611
2020's3 (10.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 50.76

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be very strong demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index50.76 (24.57)
Research Supply Index3.43 (2.92)
Research Growth Index4.51 (4.65)
Search Engine Demand Index77.19 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (50.76)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other30 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
coumarin
2H-chromen-2-one: coumarin derivative		2.4920coumarinsfluorescent dye;
human metabolite;
plant metabolite
lactic acid
Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed). 2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.		2.47202-hydroxy monocarboxylic acidalgal metabolite;
Daphnia magna metabolite
methoxsalen
Methoxsalen: A naturally occurring furocoumarin compound found in several species of plants, including Psoralea corylifolia. It is a photoactive substance that forms DNA ADDUCTS in the presence of ultraviolet A irradiation.. methoxsalen : A member of the class of psoralens that is 7H-furo[3,2-g]chromen-7-one in which the 9 position is substituted by a methoxy group. It is a constituent of the fruits of Ammi majus. Like other psoralens, trioxsalen causes photosensitization of the skin. It is administered topically or orally in conjunction with UV-A for phototherapy treatment of vitiligo and severe psoriasis.		2.5220aromatic ether;
psoralens		antineoplastic agent;
cross-linking reagent;
dermatologic drug;
photosensitizing agent;
plant metabolite
pd 98059
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one: inhibits MAP kinase kinase (MEK) activity, p42 MAPK and p44 MAPK; structure in first source. 2-(2-amino-3-methoxyphenyl)chromen-4-one : A member of the class of monomethoxyflavones that is 3'-methoxyflavone bearing an additional amino substituent at position 2'.		2.0410aromatic amine;
monomethoxyflavone		EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor;
geroprotector
pifithrin
pifithrin: a tetrahydrobenzothiazol; inhibitor of P53 that protects mice from the side effects of cancer therapy; structure in first source		2.0410aromatic ketone
pimpinellin
pimpinellin: from Heracleum laciniatum; cause of phototoxicity in patient with vitiligo		2.1310furanocoumarin
methicillin
Methicillin: One of the PENICILLINS which is resistant to PENICILLINASE but susceptible to a penicillin-binding protein. It is inactivated by gastric acid so administered by injection.. methicillin : A penicillin that is 6-aminopenicillanic acid in which one of the amino hydrogens is replaced by a 2,6-dimethoxybenzoyl group.		2.1310penicillin allergen;
penicillin		antibacterial drug
thiazoles
[no description available]		2.45201,3-thiazoles;
mancude organic heteromonocyclic parent;
monocyclic heteroarene
evans blue
Evans Blue: An azo dye used in blood volume and cardiac output measurement by the dye dilution method. It is very soluble, strongly bound to plasma albumin, and disappears very slowly.. Evans blue : An organic sodium salt that is the tetrasodium salt of 6,6'-{(3,3'-dimethyl[1,1'-biphenyl]-4,4'-diyl)bis[diazene-2,1-diyl]}bis(4-amino-5-hydroxynaphthalene-1,3-disulfonate). It is sometimes used as a counterstain, especially in fluorescent methods to suppress background autofluorescence.		2.0410organic sodium saltfluorochrome;
histological dye;
sodium channel blocker;
teratogenic agent
propargyl ether
propargyl ether: structure in first source		2.0410
paclitaxel
Taxus: Genus of coniferous yew trees or shrubs, several species of which have medicinal uses. Notable is the Pacific yew, Taxus brevifolia, which is used to make the anti-neoplastic drug taxol (PACLITAXEL).		2.0310taxane diterpenoid;
tetracyclic diterpenoid		antineoplastic agent;
human metabolite;
metabolite;
microtubule-stabilising agent
4-(n-methyl-n-nitrosamino)-1-(3-pyridyl)-1-butanone
4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone: structure; from tobacco smoke		2.1110nitrosamine;
pyridines
nicotine
(S)-nicotine : A 3-(1-methylpyrrolidin-2-yl)pyridine in which the chiral centre has S-configuration. The naturally occurring and most active enantiomer of nicotine, isolated from Nicotiana tabacum.		8403-(1-methylpyrrolidin-2-yl)pyridineanxiolytic drug;
biomarker;
immunomodulator;
mitogen;
neurotoxin;
nicotinic acetylcholine receptor agonist;
peripheral nervous system drug;
phytogenic insecticide;
plant metabolite;
psychotropic drug;
teratogenic agent;
xenobiotic
phellopterin
phellopterin: a naturally occurring furanocoumarin found in roots of Angelica dahurica; structure in first source		2.1310psoralens
coumarin 6
coumarin 6: structure in first source		2.73307-aminocoumarinsfluorochrome
peroxynitrous acid
Peroxynitrous Acid: A potent oxidant synthesized by the cell during its normal metabolism. Peroxynitrite is formed from the reaction of two free radicals, NITRIC OXIDE and the superoxide anion (SUPEROXIDES).		2.4620nitrogen oxoacid
betadex
beta-Cyclodextrins: Cyclic GLUCANS consisting of seven (7) glucopyranose units linked by 1,4-glycosidic bonds.		2.3110cyclodextrin
aurapten
aurapten: RN refers to (E)-isomer; structure given in first source. auraptene : A member of the class of coumarins that is umbelliferone in which the phenolic hydrogen has been replaced by a geranyl group. Ii is isolated from several edible fruits and vegetables and exhibits a variety of therapeutic properties.		2.1310coumarins;
monoterpenoid		antihypertensive agent;
antineoplastic agent;
antioxidant;
apoptosis inducer;
dopaminergic agent;
EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor;
gamma-secretase modulator;
gastrointestinal drug;
hepatoprotective agent;
matrix metalloproteinase inhibitor;
neuroprotective agent;
plant metabolite;
PPARalpha agonist;
vulnerary
nadp
[no description available]		2.4720
6-methyl-2-(phenylethynyl)pyridine
6-methyl-2-(phenylethynyl)pyridine: an mGlu5 antagonist. 2-methyl-6-(phenylethynyl)pyridine : A methylpyridine that coinsists of 2-methylp[yridine bearing an additional phenylethynyl group at position 6. Potent and highly selective non-competitive antagonist at the mGlu5 receptor subtype (IC50 = 36 nM) and a positive allosteric modulator at mGlu4 receptors. Centrally active following systemic administration in vivo. Reverses mechanical hyperalgesia in the inflamed rat hind paw.		2.0410acetylenic compound;
methylpyridines		anxiolytic drug;
metabotropic glutamate receptor antagonist
sib 1757
SIB 1757: a selective mGluR5 antagonist; structure in first source		2.0410
scopoletin
[no description available]		2.0510hydroxycoumarinplant growth regulator;
plant metabolite
sib 1893
SIB 1893: a selective mGluR5 antagonist; structure in first source		2.0410
collinin
collinin: the active principle of Zanthoxylum spp.; structure in first source		2.1310
5-geranyloxy-7-methoxycoumarin
5-geranyloxy-7-methoxycoumarin: structure in first source		2.1310terpene lactone
su 4312
SU4312 : A member of the class of oxindoles that is 3-methyleneoxindole in which one of the hydrogens of the methylene group has been replaced by a p-(dimethylamino)phenyl group. SU 4312 is a vascular endothelial growth factor (VEGF) receptor protein tyrosine kinase 1/2 and platelet derived growth factor (PDGF) receptor inhibitor. It also inhibits the neuronal nitric oxide synthase (NOS) and exhibits neuroprotection against NO-mediated neurotoxicity.		2.0410
warfarin
Warfarin: An anticoagulant that acts by inhibiting the synthesis of vitamin K-dependent coagulation factors. Warfarin is indicated for the prophylaxis and/or treatment of venous thrombosis and its extension, pulmonary embolism, and atrial fibrillation with embolization. It is also used as an adjunct in the prophylaxis of systemic embolism after myocardial infarction. Warfarin is also used as a rodenticide.. warfarin : A racemate comprising equal amounts of (R)- and (S)-warfarin. Extensively used as both an anticoagulant drug and as a pesticide against rats and mice.. 4-hydroxy-3-(3-oxo-1-phenylbutyl)-1-benzopyran-2-one : A member of the class of coumarins that is 4-hydroxycoumarin which is substituted at position 3 by a 1-phenyl-3-oxo-1-butyl group.		4.48210benzenes;
hydroxycoumarin;
methyl ketone
ConditionIndicatedRelationship StrengthStudiesTrials
Innate Inflammatory Response
[description not available]		02.4920
Inflammation
A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.		02.4920
Encephalitis, Polio
[description not available]		02.0610
Poliomyelitis
An acute infectious disease of humans, particularly children, caused by any of three serotypes of human poliovirus (POLIOVIRUS). Usually the infection is limited to the gastrointestinal tract and nasopharynx, and is often asymptomatic. The central nervous system, primarily the spinal cord, may be affected, leading to rapidly progressive paralysis, coarse FASCICULATION and hyporeflexia. Motor neurons are primarily affected. Encephalitis may also occur. The virus replicates in the nervous system, and may cause significant neuronal loss, most notably in the spinal cord. A rare related condition, nonpoliovirus poliomyelitis, may result from infections with nonpoliovirus enteroviruses. (From Adams et al., Principles of Neurology, 6th ed, pp764-5)		02.0610
Fish Diseases
Diseases of freshwater, marine, hatchery or aquarium fish. This term includes diseases of both teleosts (true fish) and elasmobranchs (sharks, rays and skates).		02.1710
Infections, Rhabdoviridae
[description not available]		02.1710
Carcinogenesis
The origin, production or development of cancer through genotypic and phenotypic changes which upset the normal balance between cell proliferation and cell death. Carcinogenesis generally requires a constellation of steps, which may occur quickly or over a period of many years.		02.1110
Malignant Melanoma
[description not available]		02.0510
Cancer of Skin
[description not available]		02.0510
Melanoma
A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)		02.0510
Skin Neoplasms
Tumors or cancer of the SKIN.		02.0510
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