ascorbic-acid and Psoriasis

Psoriasis is a chronic skin disease that affects approximately two per cent of the general population. Plaque psoriasis is the most common form: it usually appears as raised, red patches of inflamed skin, covered with silvery white scales. The patches often occur in a symmetrical pattern. Guttate psoriasis is a particular form of psoriasis with widespread, small erythematosquamous lesions. Streptococcal infection is suspected to be a triggering factor for the onset of guttate psoriasis, and flare-up of chronic plaque psoriasis. The previous Cochrane Review on this topic was published in 2000; it required an update because antistreptococcal treatment continues to be used to treat psoriasis, especially for the acute form of guttate psoriasis.. To assess the effects of antistreptococcal interventions for guttate and chronic plaque psoriasis.. We searched Cochrane Skin Specialised Register, Cochrane Register of Studies Online, CENTRAL, MEDLINE, Embase, LILACS, and five trials registers (January 2019). We checked the reference lists of included and excluded studies and searched conference proceedings from the American Academy of Dermatology, Society for Investigative Dermatology, and European Academy of Dermatology and Venereology.. We considered randomised controlled trials (RCTs) assessing antistreptococcal interventions (tonsillectomy or systemic antibiotic treatment) in people with clinically diagnosed acute guttate and chronic plaque psoriasis compared with placebo, no intervention, or each other.. We used standard methodological procedures expected by Cochrane. Primary outcome measures were: 1) time-to-resolution; achieving clear or almost clear skin (Physician Global Assessment (PGA) 0 or 1 or Psoriasis Area and Severity Index (PASI) 90 or 100); 2) proportion of participants with adverse effects and severe adverse effects. Secondary outcomes were: 1) proportion of participants achieving clear or almost clear skin; 2) proportion of participants achieving PASI 75 or PGA 1 to 2; 3) risk of having at least one relapse at long-term follow-up. Short-term assessment was defined as within eight weeks of the start of treatment; long-term was at least one year after the start of treatment.. We included five trials (162 randomised participants); three were conducted in a hospital dermatology department. One study declared funding by a pharmaceutical company. Participants' ages ranged from 12 to 77 years; only two participants were younger than 15 years. Mean PASI score at baseline varied from 5.7 (i.e. mild) to 23 (i.e. severe) in four studies. Twenty-three of 162 participants had streptococcus-positive throat swab culture. We did not perform a meta-analysis due to heterogeneity of participants' characteristics and interventions.None of the trials measured our efficacy primary outcome, time-to-resolution, or the secondary outcome, risk of having at least one relapse at long-term follow-up.We rated the quality of the results as very low-quality evidence, due to high risk of bias (absence of blinding of participants and caregivers, and high risk of outcome reporting bias) and imprecision (single study data with a low number of events). Hence, we are very uncertain about the results presented.Guttate psoriasisOne three-armed trial (N = 43) assessed penicillin (50,000 international units (IU)/kg/day in three doses) versus erythromycin (250 mg four times per day) versus no treatment (treatment for 14 days, with six-week follow-up from start of treatment). Adverse events and the proportion of participants achieving clear or almost clear skin were not measured.One trial (N = 20) assessed penicillin (1.6 MU (million units) intramuscularly once a day) versus no treatment (six weeks of treatment, with eight-week follow-up from start of treatment). At six-week (short-term) follow-up, no adverse events were observed in either group, and there was no statistically significant difference between the two groups in the proportion of participants with clear or almost clear skin (risk ratio (RR) 2.00, 95% confidence interval (CI) 0.68 to 5.85).One trial (N = 20) assessed rifampicin (300 mg twice daily) versus placebo (14-day treatment duration; six-week follow-up from start of treatment); none of the review outcomes were measured.These trials did not measure the proportion of participants achieving PASI 75 or PGA 1 to 2.Chronic plaque psoriasisOne trial (N = 50) assessed long-term azithromycin treatment (500 mg daily dose) versus vitamin C. Adverse events were reported in the azithromycin group (10 out of 30 had nausea and mild abdominal upset), but not in the vitamin C group. The proportion of participants who achieved clear or almost clear skin was not measu. We found only five trials (N = 162), which assessed the effects of five comparisons (systemic antibiotic treatment (penicillin, azithromycin) or tonsillectomy). Two comparisons (erythromycin compared to no treatment, and rifampicin compared to placebo) did not measure any of the outcomes of interest. There was very low-quality evidence for the outcomes that were measured, Therefore, we are uncertain of both the efficacy and safety of antistreptococcal interventions for guttate and chronic plaque psoriasis.The included trials were at unclear or high risk of bias and involved only a small number of unrepresentative participants, with limited measurement of our outcomes of interest. The studies did not allow investigation into the influence of Streptococcal infection, and a key intervention (amoxicillin) was not assessed.Further trials assessing the efficacy and tolerance of penicillin V or amoxicillin are needed in children and young adults with guttate psoriasis.

Topics: Adolescent; Adult; Aged; Anti-Bacterial Agents; Ascorbic Acid; Azithromycin; Child; Erythromycin; Humans; Middle Aged; Penicillin V; Psoriasis; Randomized Controlled Trials as Topic; Rifampin; Streptococcal Infections; Tonsillectomy; Vitamins

Topics: Abnormalities, Drug-Induced; Animals; Ascorbic Acid; Child; Chloroquine; Enzymes; Eye Diseases; Female; Humans; Lysosomes; Pigmentation; Porphyrias; Pregnancy; Protein Biosynthesis; Psoriasis; Pyridoxine; Rabbits; Retina; Ultraviolet Rays

The modulation of immunometabolic pathways is emerging as a promising therapeutic target for immune-mediated diseases. However, the immunometabolic features of psoriatic disease and the potential targets for immunometabolic intervention in the different T-cell subsets involved in its pathogenesis remain unclear.. In this study, we analyzed circulating blood single-cell data from healthy controls (HC), psoriasis (PSO), and psoriatic arthritis (PSA) patients, and revealed their metabolic features of T-cell subsets: CD4+ central memory T cells (TCMs), CD8+ effective memory T cells (TEMs), regulatory T cells (Tregs), mucosal-associated invariant T cells (MAITs ), and γδ T cells. Pearson test was performed to determine the linkages between differential metabolic and inflammatory pathways. Based on these results, we also analyzed the potential impacts of biological antibodies on differential metabolic pathways by comparing the immunometabolism differences between PSA patients without and with biological treatment.. Our results suggest that upregulation of ascorbate and aldarate metabolism, as well as fatty acid degradation, may enhance the immune suppression of Tregs. Enhanced metabolism of alpha-linolenic acid, linoleic acid, and arachidonic acid may inhibit the pro-inflammatory functions of CD4+ TCMs and CD8+ TEMs in PSO and PSA, and protect the immune suppression of Tregs in PSA. We propose that supporting ascorbic acid and fatty acid metabolic pathways may be an adjunctive reprogramming strategy with adalimumab and etanercept therapy.. These findings not only provide insights into immunometabolism characteristics of psoriatic disease, but also offer preliminary options for the auxiliary treatment of psoriasis.

Topics: Arthritis, Psoriatic; Ascorbic Acid; Humans; Psoriasis; T-Lymphocyte Subsets; Transcriptome

Psoriasis is a chronic inflammatory skin disease in which inflammatory cytokines play a major role in its pathogenesis. Because DDH-1, a novel amphipathic ascorbic acid derivative, has been recently shown to reduce inflammatory cytokine expression in human keratinocytes in vitro, we investigated its effect on imiquimod-induced psoriasis-like skin lesions in C57BL/6 mice. We first found that IL-1β and TNF-α mRNA expression was significantly decreased in the skin lesions treated with DDH-1. Furthermore, cutaneous administration of DDH-1 ameliorated psoriasis-like skin lesions. These results suggest that DDH-1 may be effective in the prevention and supplemental treatment of psoriasis.

Topics: Animals; Anti-Inflammatory Agents; Ascorbic Acid; Cytokines; Female; Imiquimod; Mice, Inbred C57BL; Psoriasis; Skin

Recent studies have revealed critical roles that nuclear receptors like LXR-α (Liver X Receptor- alpha) plays as a class of post-transcriptional gene regulator in skin development and diseases. Keeping in view the fact that LXR-α plays crucial role in keratinocyte proliferation and differentiation, it becomes imperative to dissect the pathways and role of LXR-α genomics in the pathogenesis of psoriasis with ultimate aim to explore novel preventive/therapeutic strategies as treatment options. To explore the effects of agonists and activators of LXR-α on its own gene expression and the putative targets in psoriatic keratinocytes. Identification of promoter sequences for (vitamin D receptor) VDR and Catalase were done using in silico analysis followed by β-galactosidase (β-gal) reporter plasmid assay in keratinocytes from clinically heathy subjects. Determination of relative levels of LXR-α,VDR and catalase in control versus treated cells upon activation of LXR-α with Atorvastatin + 22R hydroxycholestrol and Ascorbic acid + 22R hydroxycholestrol was done by PCR and Cell Proliferation Assay. The cells transfected with the reporter plasmid element for VDR and catalase showed more than 5 and 4 fold increase respectively in the β-gal activity compared to the control. An increase of 55% in LXR-α gene expression at RNA level was observed in Atorvastatin + 22-R hydroxycholestrol compared to 24% in Ascorbic acid + 22-ROH cholesterol. The expression of the VDR and Catalase was significantly increased in both treated keratinocytes compared to its normal counterpart.

Topics: Adolescent; Adult; Antioxidants; Ascorbic Acid; Atorvastatin; Female; Gene Expression Regulation; Heptanoic Acids; Humans; Hydroxycholesterols; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Keratinocytes; Liver X Receptors; Male; Orphan Nuclear Receptors; Psoriasis; Pyrroles

To analyze the clinical characteristics and combined use of chemical and traditional Chinese medicine (TCM) medicine of hospitalized patients with psoriasis base on real world database, 2 991 cases of hospitalized patients with psoriasis in hospital information system (HIS) database from 16 hospitals in China were analyzed for general hospitalization information, combined diseases and combined use of drugs et al. The results showed that half of inpatients aged 18-45 years old. The most common syndrome of TCM was intrinsic blood heat. More than 1/3 inpatients' hospitalization time was 18-25 days, and the average expense of hospitalization was 6 989. 20 RMB. The top five combined diseases were hypertension, non-alcoholic fatty liver disease, diabetes, upper respiratory tract infection and lipoprotein disorders. Medicine information analysis showed 599 chemical medicines and 341 TCMs were used and combined use of drugs was common in clinical practice. Licorice extract medicine was the most common combined TCM with western medicine; in the next two places were compound Qingdai capsule and tripterygium glycosides. The most common combined use of chemical medicines were Vitamin C, calcium gluconate, ketotifen, cetirizine, retinoic acid and external use glucocorticoid. Anti-inflammatory and liver protection, clearing heat and toxic materials, activating blood and dissolving stasis were the most common combined TCM medicine with western medicine, while the most common combined chemical medicine with TCM were anti-allergic, anti-infection, glucocorticoid and retinoic acid. In conclusion, half of hospitalized patients of psoriasis were young adults. The main type of combined diseases was metabolic disorders and upper respiratory infections. Combined use of chemical medicine and TCM was common in clinical practice. Licorice extract medicine was the most common combined TCM with western medicine.

Topics: Adolescent; Adult; Aged; Ascorbic Acid; Calcium Gluconate; Cetirizine; China; Drugs, Chinese Herbal; Female; Glucocorticoids; Humans; Ketotifen; Male; Medicine, Chinese Traditional; Middle Aged; Psoriasis; Tretinoin; Young Adult

Experiments on erythrocytes of patients were used to study the influence of remaxol and ademetionin on the exchange of thiols. The values of thioldisulfide exchange indicators were determined in the beginning of the period of observation and at the end of every week within one month. Patients who received hepato-protectors in combination with higher-level thiols showed positive dynamics in disease treatment as compared to patients receiving standard therapy. The concentration of restored glutathione and proteins of hydrosulfide groups and the activity of glutathione peroxidase are informative criteria for estimating the course of disease current and the efficiency of therapy of widespread forms of psoriasis.

Topics: Ascorbic Acid; Calcium Gluconate; Erythrocytes; Female; Folic Acid; Glutathione; Glutathione Peroxidase; Humans; Infusions, Intravenous; Male; Psoriasis; S-Adenosylmethionine; Severity of Illness Index; Succinates; Sulfhydryl Compounds; Vitamin B 12

The correcting action of omegalicin against the background of conventional treatment of psoriasis was investigated. It is established that omegalicin moderately increases the generation of active forms of oxygen needed to suppress the processes of proliferation at the expense of changing the activity of catalase, superoxide dismutase and glutathione peroxidase.

Topics: Ascorbic Acid; Catalase; Disulfides; Enzyme Induction; Fatty Acids, Omega-3; Glutathione Peroxidase; Humans; Malondialdehyde; Oxidation-Reduction; Oxygen; Psoriasis; Sulfhydryl Compounds; Sulfinic Acids; Superoxide Dismutase

Frequent or rare, minor or serious, numerous skin conditions exist. Allergic, inflammatory, infectious or bullous, dermatoses may also reveal underlying pathologies.

Topics: Acne Vulgaris; Adrenal Cortex Hormones; Ascorbic Acid; Ascorbic Acid Deficiency; Dermatomyositis; Erythema; Humans; Lupus Erythematosus, Cutaneous; Psoriasis; Skin Diseases; Skin Diseases, Vesiculobullous; Vitamin A; Vitamin A Deficiency

Reactive oxygen species play an important role in inflammatory skin diseases such as psoriasis. Reactive oxygen species synthesis is catalysed by iron and some species are scavenged by ascorbic acid. The aim of this work was to assess iron and ascorbic acid in uninvolved and involved psoriatic dermis and to compare the corresponding concentrations in the dermis of healthy subjects. Microdialysis associated with atomic absorption spectrometry and gas chromatography-mass spectrometry was used to assess iron and ascorbic acid, respectively. Seven psoriatic patients and five healthy volunteers were studied. Iron concentrations in the involved (57.1 +/- 19.3 microg/l) and uninvolved (49.7 +/- 27.1 microgl/l) psoriatic dermis were higher than the corresponding value determined in the dermis of healthy subjects (21.8 +/- 2.4 microg/l) (p<0.05). Ascorbic acid in involved (47.3 +/- 8.2 microg/ml) and uninvolved (42.0 +/- 14.0 microg/ml) psoriatic dermis was statistically lower than that found in healthy dermis (176.8 +/- 29.0 microg/ml) (p<0.05). These results demonstrate that psoriatic patients exhibit high iron and low ascorbic acid concentrations in the dermis, but there were no significant differences between involved and uninvolved skin.

Topics: Adult; Ascorbic Acid; Gas Chromatography-Mass Spectrometry; Humans; Iron; Microdialysis; Middle Aged; Psoriasis; Skin; Spectrophotometry, Atomic

Psoriasis is a chronic inflammatory skin disease. Reactive oxygen species are thought to play a critical role in inflammation and are scavenged by antioxidants.. We wanted to know whether the total antioxidative capacity or single antioxidative components in sera from psoriasis patients are decreased.. Well-known antioxidants of the serum were measured using commercial kits or determined by HPLC in the sera of 33 inpatients with severe psoriasis and in 36 healthy control persons. The total antioxidative capacity was measured using the ability of endogenous antioxidants to scavenge the 2, 2'-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) radical cation.. Several single antioxidative components were slightly elevated when considered groupwise, namely tocopherol (p = 0.001), bilirubin (p = 0.001) and urate which was increased over controls by about 33% (p= 0.01). Other parameters such as total protein and thiol content and ascorbic acid did not differ from controls.. To our surprise the total antioxidative activity was normal in sera from psoriasis patients although some components such as urate were even elevated.

Topics: Antioxidants; Ascorbic Acid; Bilirubin; Blood Proteins; Chromatography, High Pressure Liquid; Humans; Psoriasis; Sulfhydryl Compounds; Uric Acid; Vitamin E

Topics: Adult; Ascorbic Acid; Child; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Interferon Type I; Male; Prodigiozan; Psoriasis; Thiosulfates

Topics: Ascorbic Acid; Drug Combinations; Female; Ficusin; Folic Acid; Humans; Male; Methotrexate; Psoriasis; Ultraviolet Therapy

Topics: Adult; Age Factors; Androgens; Ascorbic Acid; Female; Humans; Male; Psoriasis; Psychology; Puberty; Sex Factors

Topics: Adolescent; Adult; Aged; Ascorbic Acid; Blood Proteins; Child; Female; Humans; Male; Middle Aged; Oxidation-Reduction; Psoriasis; Seasons; Sulfhydryl Compounds

Topics: Adolescent; Adult; Aged; Ascorbic Acid; DNA; Humans; Middle Aged; Psoriasis; RNA; Skin

Topics: Animals; Ascorbic Acid; Catalase; Chick Embryo; Collagen; Dithiothreitol; Humans; Iron; Keloid; Ketoglutaric Acids; Lidocaine; Mixed Function Oxygenases; Proline; Psoriasis; Skin; Tritium

Topics: Adolescent; Adult; Ascorbic Acid; Ascorbic Acid Deficiency; Capillary Fragility; Cold Climate; Female; Humans; Male; Middle Aged; Psoriasis; Skin Diseases

Topics: Adolescent; Adult; Aged; Ascorbic Acid; Copper; Female; Humans; Male; Middle Aged; Psoriasis

Topics: Adolescent; Adult; Aged; Ascorbic Acid; Copper; Female; Humans; Male; Middle Aged; Psoriasis

Topics: Adult; Ascorbic Acid; Female; Humans; Male; Middle Aged; Psoriasis; Thiamine

Topics: Adult; Aged; Alloxan; Anti-Inflammatory Agents; Ascorbic Acid; Child; Dermatitis, Exfoliative; Female; Humans; Iron; Male; Middle Aged; Psoriasis; Sodium

Topics: Ascorbic Acid; Autoradiography; Folic Acid; Histidine; Humans; Male; Proteins; Psoriasis; RNA; Skin; Tritium; Uridine

Topics: Anabolic Agents; Ascorbic Acid; Humans; Psoriasis; Vitamin B Complex

Topics: Ascorbic Acid; Biopsy; Carcinoma in Situ; Darier Disease; Drug Therapy; Humans; Pathology; Psoriasis; Vitamin A

Topics: Ascorbic Acid; Drug Therapy; Foot; Foot Diseases; Hand Dermatoses; Humans; Nails; Niacin; Ointments; Psoriasis; Vitamin A

Topics: Antimalarials; Arthritis; Arthritis, Rheumatoid; Ascorbic Acid; Gout; Humans; Psoriasis; Spondylitis; Spondylitis, Ankylosing; Sunlight; Triamcinolone; Ultraviolet Rays; Vitamin A

Topics: Acne Vulgaris; Adolescent; Amino Acids; Ascorbic Acid; Dermatitis; Dermatitis, Contact; Dermatology; Drug Eruptions; Eczema; Erythema; Glutamates; Melanosis; Neurodermatitis; Pantothenic Acid; Polyarteritis Nodosa; Psoriasis; Tablets; Tiopronin; Toxicology; Urticaria

Topics: Ascorbic Acid; Corrinoids; Folic Acid; Hematinics; Humans; Methyltestosterone; Niacin; Niacinamide; Psoriasis; Vitamin B 12

Topics: Ascorbic Acid; Humans; Psoriasis; Vitamin A; Vitamins

Topics: Ascorbic Acid; Corrinoids; Folic Acid; Hematinics; Psoriasis; Vitamin B 12; Vitamins

Topics: Adrenocorticotropic Hormone; Arthritis; Arthritis, Rheumatoid; Ascorbic Acid; Desoxycorticosterone; Desoxycorticosterone Acetate; Psoriasis; Vitamins

Topics: Ascorbic Acid; Hesperidin; Niacin; Nicotinic Acids; Psoriasis