Page last updated: 2024-08-05 11:25:26

1-benzothiophenes

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ChEBI ID: 38836

Members (33)

MemberDefinitionRole
(2R,3R,4S)-4-(1-benzothiophen-3-yl)-2-ethoxy-3-(3-hydroxypropyl)-3,4-dihydro-2H-pyran-6-carboxylic acid prop-2-enyl ester(2R,3R,4S)-4-(1-benzothiophen-3-yl)-2-ethoxy-3-(3-hydroxypropyl)-3,4-dihydro-2H-pyran-6-carboxylic acid prop-2-enyl ester
(2S,4S)-4-(1-benzothiophen-3-yl)-2-[[4-(hydroxymethyl)phenyl]methoxy]-N-(phenylmethyl)-3,4-dihydro-2H-pyran-6-carboxamide(2S,4S)-4-(1-benzothiophen-3-yl)-2-[[4-(hydroxymethyl)phenyl]methoxy]-N-(phenylmethyl)-3,4-dihydro-2H-pyran-6-carboxamide
(4-methyl-1-piperazinyl)-(2-thieno[3,2-b][1]benzothiolyl)methanone(4-methyl-1-piperazinyl)-(2-thieno[3,2-b][1]benzothiolyl)methanone
[(2R,3R,4S)-4-(1-benzothiophen-3-yl)-2-ethoxy-3-(3-hydroxypropyl)-3,4-dihydro-2H-pyran-6-yl]-[4-(phenylmethyl)-1-piperazinyl]methanone[(2R,3R,4S)-4-(1-benzothiophen-3-yl)-2-ethoxy-3-(3-hydroxypropyl)-3,4-dihydro-2H-pyran-6-yl]-[4-(phenylmethyl)-1-piperazinyl]methanone
[(2S,4S)-4-(1-benzothiophen-3-yl)-2-[[4-(hydroxymethyl)phenyl]methoxy]-3,4-dihydro-2H-pyran-6-yl]-[4-(phenylmethyl)-1-piperazinyl]methanone[(2S,4S)-4-(1-benzothiophen-3-yl)-2-[[4-(hydroxymethyl)phenyl]methoxy]-3,4-dihydro-2H-pyran-6-yl]-[4-(phenylmethyl)-1-piperazinyl]methanone
1-(1-(2-benzo(b)thienyl)cyclohexyl)piperidineA tertiary amino compound that consists of cyclohexane having piperidin-1-yl and benzothiophen-2-yl groups attached at position 1. A potent dopamine re-uptake inhibitor with a behavioral profile different from that of phencyclidine (PCP) and similar to that of cocaine.1-[1-(1-benzothiophen-2-yl)cyclohexyl]piperidine
2-(5-Chlorobenzo[b]thiophen-3-yl)acetic acid2-(5-Chlorobenzo[b]thiophen-3-yl)acetic acid
2-[(3-chloro-1-benzothiophen-2-yl)methylideneamino]phenol2-[(3-chloro-1-benzothiophen-2-yl)methylideneamino]phenol
2-{1-[2-(1-benzothiophen-5-ylamino)-2-oxoethyl]cyclohexyl}acetic acid2-{1-[2-(1-benzothiophen-5-ylamino)-2-oxoethyl]cyclohexyl}acetic acid
2-Benzo[b]thiophen-3-ylacetic acid2-Benzo[b]thiophen-3-ylacetic acid
3-chloro-4-fluoro-N-(3-pyridinyl)-1-benzothiophene-2-carboxamide3-chloro-4-fluoro-N-(3-pyridinyl)-1-benzothiophene-2-carboxamide
3-chloro-6-methyl-N-(3-pyridinyl)-1-benzothiophene-2-carboxamide3-chloro-6-methyl-N-(3-pyridinyl)-1-benzothiophene-2-carboxamide
3-chloro-N-[3-(1-imidazolyl)propyl]-6-nitro-1-benzothiophene-2-carboxamide3-chloro-N-[3-(1-imidazolyl)propyl]-6-nitro-1-benzothiophene-2-carboxamide
3-chloro-N-[3-(4-morpholinyl)propyl]-6-nitro-1-benzothiophene-2-carboxamide3-chloro-N-[3-(4-morpholinyl)propyl]-6-nitro-1-benzothiophene-2-carboxamide
3-methyl-1-benzothiophene-2-carbaldehyde oxime3-methyl-1-benzothiophene-2-carbaldehyde oxime
3,4-dichloro-N-[(1-methyl-4-pyrazolyl)methyl]-1-benzothiophene-2-carboxamide3,4-dichloro-N-[(1-methyl-4-pyrazolyl)methyl]-1-benzothiophene-2-carboxamide
3,6-dichloro-N-(3-pyridinylmethyl)-1-benzothiophene-2-carboxamide3,6-dichloro-N-(3-pyridinylmethyl)-1-benzothiophene-2-carboxamide
3,6-dichloro-N-(4-methyl-2-pyridinyl)-1-benzothiophene-2-carboxamide3,6-dichloro-N-(4-methyl-2-pyridinyl)-1-benzothiophene-2-carboxamide
3,7-dichloro-N-[3-(1-imidazolyl)propyl]-6-methoxy-1-benzothiophene-2-carboxamide3,7-dichloro-N-[3-(1-imidazolyl)propyl]-6-methoxy-1-benzothiophene-2-carboxamide
abbott 66193Dehydroxyzyleuton
ANA-12A secondary carboxamide that is anthranilic acid in which the carboxy group has undergone condensation with the primary amino group of alpha-amino-epsilon-caprolactam, while the aryl-amino group has undergone condensation with the carboxy group of 1-benzothiophene-2-carboxylic acid. It is a selective, non-competitive antagonist of tropomyosin receptor kinase B (TrkB, also known as tyrosine receptor kinase B).ANA-12
benzothiophene1-benzothiophene
gsk 1016790aA tertiary carboxamide that is piperazine in which one of the amino groups has undergone condensation with the carboxy group of N-[(2,4-dichlorophenyl)sulfonyl]-L-serine, while the other has undergone condensation with the carboxy group of N-(1-benzothiophen-2-ylcarbonyl)-L-leucine. It is a cell-permeable, potent and selective agonist of the TRPV4 (transient receptor potential vanilloid 4) channel.GSK1016790A
ly 117018A member of the class of 1-benzothiophenes that is raloxifene in which the piperidin-1-yl group has been replaced by a pyrrolidin-1-yl group.LY 117018
metizolinemetizoline
N-(1-benzothiophen-7-ylmethyl)-2-thiophenecarboxamideN-(1-benzothiophen-7-ylmethyl)-2-thiophenecarboxamide
N-phenyl-2-benzo[g][1]benzothiolecarboxamideN-phenyl-2-benzo[g][1]benzothiolecarboxamide
N,N-bis(2-methoxyethyl)-2-thieno[3,2-b][1]benzothiolecarboxamideN,N-bis(2-methoxyethyl)-2-thieno[3,2-b][1]benzothiolecarboxamide
N2-phenyl-3-methylbenzo[b]thiophene-2-carbothioamideN2-phenyl-3-methylbenzo[b]thiophene-2-carbothioamide
raloxifeneA member of the class of 1-benzothiophenes that is 1-benzothiophene in which the hydrogens at positions 2, 3, and 6 have been replaced by p-hydroxyphenyl, p-[2-(piperidin-1-yl)ethoxy]benzoyl, and hydroxy groups, respectively.raloxifene
sertaconazoleA member of the class of imidazoles that carries a 2-[(7-chloro-1-benzothiophen-3-yl)methoxy]-2-(2,4-dichlorophenyl)ethyl group at position 1.1-{2-[(7-chloro-1-benzothiophen-3-yl)methoxy]-2-(2,4-dichlorophenyl)ethyl}imidazole
statticA member of the class of 1-benzothiophenes that is 1-benzothiophene-1,1-dioxide substituted at position 6 by a nitro group. Used as a radiosensitising agent for esophageal squamous cell carcinoma.stattic
zileutonA member of the class of 1-benzothiophenes that is 1-benzothiophene in which the hydrogen at position 2 is replaced by a 1-[carbamoyl(hydroxy)amino]ethyl group. A selective 5-lipoxygenase inhibitor, it inhibits the formation of leukotrienes LTB4, LTC4, LDT4, and LTE4. It is used for the management of chronic asthma.zileuton

Research

Studies (1,336)

TimeframeStudies, Drugs in This Class (%)All Drugs %
pre-199050 (3.74)18.7374
1990's300 (22.46)18.2507
2000's349 (26.12)29.6817
2010's481 (36.00)24.3611
2020's156 (11.68)2.80

Study Types

Publication TypeStudies, Drugs in This Class (%)All Drugs (%)
Trials96 (6.08%)5.53%
Reviews91 (5.77%)6.00%
Case Studies13 (0.82%)4.05%
Observational0 (0.00%)0.25%
Other1,378 (87.33%)84.16%