ascorbic-acid and Carcinoma--Papillary

The levels of lipid peroxidation products (TBARS), non-enzymatic antioxidants and enzymatic antioxidants activity were investigated in plasma and erythrocytes of twenty clinically diagnosed stage II papillary thyroid cancer patients and an equal number of age and sex matched healthy subjects. An increase in the levels of lipid peroxidation products, decrease in non-enzymatic antioxidants levels and enzymatic antioxidant activities in plasma and erythrocytes were detected in papillary thyroid cancer patients as compared to healthy subjects. Impairment in antioxidant defence mechanisms are responsible for enhanced lipid peroxidation observed in plasma and erythrocytes of papillary thyroid cancer patients.

Topics: Adult; Antioxidants; Ascorbic Acid; Carcinoma, Papillary; Case-Control Studies; Catalase; Erythrocyte Membrane; Erythrocytes; Female; Glutathione; Glutathione Peroxidase; Humans; India; Lipid Peroxidation; Male; Middle Aged; Neoplasm Staging; Nutritional Status; Superoxide Dismutase; Thiobarbituric Acid Reactive Substances; Thyroid Neoplasms; Vitamin E

Topics: Adult; Aged; Ascorbic Acid; Carcinoma, Papillary; Female; Humans; Immunoglobulins; Lymphocyte Activation; Middle Aged; Ovarian Neoplasms; Oxidation-Reduction; RNA, Neoplasm

A case of reticulum cell sarcoma apparently successfully treated with mega ascorbic acid therapy is described briefly. While the patient continued a large maintenance dose of ascorbic acid, a papillary thyroid carcinoma developed clinically. The role of ascorbic acid in the body resistance to cancer and in tumour prevention is discussed.

Topics: Adult; Ascorbic Acid; Carcinoma, Papillary; Humans; Lymphoma, Large B-Cell, Diffuse; Male; Thyroid Neoplasms