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vitamin B1
Any member of the group of 1,3-thiazolium cations that exhibit biological activity against vitamin B1 deficiency in animals. Symptoms of vitamin B1 deficiency include constipation, loss of apetite, fatigue, nausea, delirium, blurry vision and muscle weakness. Severe vitamin B1 deficiency can also lead to a disease known as beriberi. Vitamin B1 consists of the vitamer thiamin and its acid, aldehyde and phosphorylated derivatives (and their corresponding ionized, salt and hydrate forms).
ChEBI ID: 26948
Members (7)
| Member | Definition | Role |
|---|---|---|
| thiamine | A primary alcohol that is 1,3-thiazol-3-ium substituted by (4-amino-2-methylpyrimidin-5-yl)methyl, methyl and 2-hydroxyethyl groups at positions 3, 4 and 5, respectively. | thiamine(1+) |
| thiamine | thiamine(1+) chloride | |
| thiamine hydrochloride | A hydrochloride obtained by combining thiamine chloride with one molar equivalent of hydrochloric acid. | thiamine hydrochloride |
| thiamine monophosphate | An organic chloride salt of thiamine(1+) monophosphate. | thiamine(1+) monophosphate chloride |
| thiamine pyrophosphate | An organic chloride salt of thiamine(1+) diphosphate. | thiamine(1+) diphosphate chloride |
| thiamine pyrophosphate | Trianion of thiamine(1+) diphosphate arising from deprotonation of the four OH groups of the triphosphate. | thiamine(1+) triphosphate(4-) |
| thiamine triphosphate | An ammonium betaine that is the conjugate base of thiamine(1+) triphosphate arising from the deptoronation of one of the hydroxy groups of the terminal phosphate group. | thiamine(1+) triphosphate(1-) |
Research
Studies (11,160)
| Timeframe | Studies, Drugs in This Class (%) | All Drugs % |
|---|---|---|
| pre-1990 | 6,828 (61.18) | 18.7374 |
| 1990's | 922 (8.26) | 18.2507 |
| 2000's | 1,210 (10.84) | 29.6817 |
| 2010's | 1,467 (13.15) | 24.3611 |
| 2020's | 733 (6.57) | 2.80 |
Study Types
| Publication Type | Studies, Drugs in This Class (%) | All Drugs (%) |
|---|---|---|
| Trials | 336 (2.50%) | 5.53% |
| Reviews | 781 (5.81%) | 6.00% |
| Case Studies | 955 (7.10%) | 4.05% |
| Observational | 26 (0.19%) | 0.25% |
| Other | 11,351 (84.40%) | 84.16% |