vitamin B1

Any member of the group of 1,3-thiazolium cations that exhibit biological activity against vitamin B1 deficiency in animals. Symptoms of vitamin B1 deficiency include constipation, loss of apetite, fatigue, nausea, delirium, blurry vision and muscle weakness. Severe vitamin B1 deficiency can also lead to a disease known as beriberi. Vitamin B1 consists of the vitamer thiamin and its acid, aldehyde and phosphorylated derivatives (and their corresponding ionized, salt and hydrate forms).

ChEBI ID: 26948

Members (7)

Member	Definition	Role
thiamine	A primary alcohol that is 1,3-thiazol-3-ium substituted by (4-amino-2-methylpyrimidin-5-yl)methyl, methyl and 2-hydroxyethyl groups at positions 3, 4 and 5, respectively.	thiamine(1+)
thiamine		thiamine(1+) chloride
thiamine hydrochloride	A hydrochloride obtained by combining thiamine chloride with one molar equivalent of hydrochloric acid.	thiamine hydrochloride
thiamine monophosphate	An organic chloride salt of thiamine(1+) monophosphate.	thiamine(1+) monophosphate chloride
thiamine pyrophosphate	An organic chloride salt of thiamine(1+) diphosphate.	thiamine(1+) diphosphate chloride
thiamine pyrophosphate	Trianion of thiamine(1+) diphosphate arising from deprotonation of the four OH groups of the triphosphate.	thiamine(1+) triphosphate(4-)
thiamine triphosphate	An ammonium betaine that is the conjugate base of thiamine(1+) triphosphate arising from the deptoronation of one of the hydroxy groups of the terminal phosphate group.	thiamine(1+) triphosphate(1-)

Research

Studies (11,160)

Timeframe	Studies, Drugs in This Class (%)	All Drugs %
pre-1990	6,828 (61.18)	18.7374
1990's	922 (8.26)	18.2507
2000's	1,210 (10.84)	29.6817
2010's	1,467 (13.15)	24.3611
2020's	733 (6.57)	2.80

Study Types

Publication Type	Studies, Drugs in This Class (%)	All Drugs (%)
Trials	336 (2.50%)	5.53%
Reviews	781 (5.81%)	6.00%
Case Studies	955 (7.10%)	4.05%
Observational	26 (0.19%)	0.25%
Other	11,351 (84.40%)	84.16%