An EC 4.3.1.* (ammonia-lyase) inhibitor that interferes with the action of histidine ammonia-lyase (EC 4.3.1.3).
ChEBI ID: 77703
| Member | Definition | Class |
|---|---|---|
| cysteine | An optically active form of cysteine having L-configuration. | L-cysteine zwitterion; L-cysteine |
| nitromethane | A primary nitroalkane that is methane in which one of the hydrogens is replace by a nitro group. A polar solvent (b.p. 101 degreeC), it is an important starting material in organic synthesis. It is also used as a fuel for rockets and radio-controlled models. | nitromethane |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 24 (10.21) | 18.7374 |
| 1990's | 17 (7.23) | 18.2507 |
| 2000's | 77 (32.77) | 29.6817 |
| 2010's | 103 (43.83) | 24.3611 |
| 2020's | 14 (5.96) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 5 (2.11%) | 6.00% |
| Case Studies | 22 (9.28%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 210 (88.61%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 48.5577 | 1 | 1 |
| thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 30.6379 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Carboxypeptidase A1 | Bos taurus (cattle) | Ki | 350.0000 | 1 | 1 |
| Carboxypeptidase A1 | Homo sapiens (human) | Ki | 350.0000 | 1 | 1 |
| Chain A, Serine acetyltransferase | Haemophilus influenzae | Ki | 1.0000 | 1 | 1 |
| Cystine/glutamate transporter | Homo sapiens (human) | IC50 | 116.0000 | 1 | 1 |
| Cystine/glutamate transporter | Homo sapiens (human) | Ki | 59.0000 | 1 | 1 |
| Excitatory amino acid transporter 1 | Homo sapiens (human) | IC50 | 376.0000 | 1 | 1 |
| Excitatory amino acid transporter 3 | Homo sapiens (human) | IC50 | 161.0000 | 1 | 1 |
| Kinesin-like protein KIF11 | Homo sapiens (human) | IC50 | 63.0000 | 1 | 1 |
| Proton-coupled amino acid transporter 1 | Homo sapiens (human) | Ki | 46,000.0000 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Chain A, putative amino-acid transporter periplasmic solute-binding protein | Campylobacter jejuni | Kd | 0.1400 | 1 | 1 |