A 2-aminopurine that is guanine bearing a single methyl substituent.
ChEBI ID: 25305
| Member | Definition | Role |
|---|---|---|
| 1-methylguanine | 1-methylguanine | |
| o-(6)-methylguanine | A methylguanine in which the methyl group is positioned on the oxygen at position 6. Formed in DNA by alkylation of the oxygen atom of guanine, most often by N-nitroso compounds and sometimes due to methylation by other compounds such as endogenous S-adenosylmethionine, it base-pairs to thymine rather than cytidine, causing a G:C to A:T transition in DNA. | 6-O-methylguanine |
| Timeframe | Studies, Drugs in This Class (%) | All Drugs % |
|---|---|---|
| pre-1990 | 285 (37.55) | 18.7374 |
| 1990's | 244 (32.15) | 18.2507 |
| 2000's | 107 (14.10) | 29.6817 |
| 2010's | 96 (12.65) | 24.3611 |
| 2020's | 27 (3.56) | 2.80 |
| Publication Type | Studies, Drugs in This Class (%) | All Drugs (%) |
|---|---|---|
| Trials | 4 (0.51%) | 5.53% |
| Reviews | 49 (6.26%) | 6.00% |
| Case Studies | 1 (0.13%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 729 (93.10%) | 84.16% |