Cumulative Trauma Disorders

Harmful and painful condition caused by overuse or overexertion of some part of the musculoskeletal system, often resulting from work-related physical activities. It is characterized by inflammation, pain, or dysfunction of the involved joints, bones, ligaments, and nerves.

Synonym
Strain Injury, Repetition
Trauma Disorders, Cumulative
Repetitive Motion Disorders
Repetition Strain Injury
Cumulative Trauma Disorders
Injury, Repetition Strain
Overuse Syndrome
Repetitive Strain Injury
Overuse Injury
Repetitive Stress Injury

Excerpt	Reference
"Repetitive strain injury is caused by recurrent overuse, resulting in microtrauma to tissues."	( Sheon, RP, 1997)

Excerpt	Reference
"Unlike other forms of overuse injury (tendonitis, stress fracture), CCS does not respond to rest, anti-inflammatory medications, or physical therapy."	( Detmer, DE; Girdley, F; Turnipseed, W, 1989)
"When treating patients with repetitive strain injury, discriminative sensory motor skills must be carefully assessed and may need to be addressed as part of an effective treatment program."	( Byl, N; McKenzie, A; Melnick, M; Merzenich, M; Oakes, A; Scott, P; Wilson, F, 1996)
"Considered an overuse injury that compromises the dense and tough fascial attachments of the tibialis posterior and/or tibialis anterior muscles from the tibia, it responds well to a multiphase treatment plan that incorporates plyometric strengthening and conditioning exercises."	( Herring, KM, 2006)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	17 (4.05)	23.3326
1990's	100 (23.81)	12.5806
2000's	160 (38.10)	18.1394
2010's	124 (29.52)	28.8240
2020's	19 (4.52)	9.53

Drug	Relationship Strength	Studies	Trials
ammonium hydroxide	low	1	0
salicylic acid	low	1	0
creatine	medium	2	1
lactic acid	medium	10	3
glycerol	low	1	0
methanol	low	2	0
taurine	low	1	0
uric acid	low	1	0
acetaminophen	medium	1	1
amitriptyline	medium	3	1
baclofen	low	1	0
bromhexine	low	1	0
bupivacaine	medium	2	1
clonazepam	low	2	0
clonidine	low	1	0
valproic acid	low	1	0
erythrosine	low	1	0
fluoxetine	medium	1	1
glutaral	low	1	0
glyphosate	low	21	0
ibuprofen	medium	4	1
lidocaine	medium	3	1
indomethacin	medium	2	1
loxoprofen	medium	1	1
nitroglycerin	low	2	0
pentoxifylline	medium	1	1
prazosin	medium	1	1
propranolol	low	1	0
iodoacetic acid	low	1	0
trihexyphenidyl	low	1	0
hydroxyproline	low	1	0
methylprednisolone acetate	low	2	0
dehydroepiandrosterone	medium	1	1
serine	low	1	0
aspartic acid	low	1	0
glutamine	medium	1	1
sucrose	low	1	0
colchicine	low	1	0
threonine	low	1	0
phencyclidine	low	1	0
isoprene	low	1	0
acrylamide	low	1	0
methylprednisolone	medium	2	1
nafcillin	low	1	0
betamethasone	low	2	0
malondialdehyde	low	3	0
eosine yellowish-(ys)	low	1	0
trimecaine	low	1	0
s,n,n'-tripropylthiocarbamate	low	1	0
sabinene	low	2	0
technetium	low	2	0
gadolinium	low	1	0
gold	low	1	0
trolamine salicylate	low	9	0
cetylpyridinium chloride anhydrous	low	1	0
glutamic acid	medium	2	1
substance p	low	8	0
ng-nitroarginine methyl ester	low	1	0
fomesafen	low	1	0
3-iodobenzylguanidine	low	1	0
n-acetylaspartic acid	low	1	0
nicotine	low	1	0
fibrinogen	low	1	0
brl 44408	low	1	0
naproxen	low	2	0
technetium tc 99m pentetate	low	1	0
angiotensin ii	low	1	0
cortisone	low	3	0
glycogen	low	1	0
bradykinin	low	1	0
glucosamine	low	1	0
oxytocin	low	1	0
inositol 3-phosphate	low	1	0
arachidonic acid	low	1	0
zithromax	low	2	0
pyrophosphate	low	1	0
curcumin	medium	2	1
myelin basic protein	low	1	0
dinoprostone	low	5	0
leukotriene b4	low	1	0
kallidin	low	1	0
lead	low	1	0
enalapril	low	1	0
silicon	low	1	0
technetium tc 99m pyrophosphate	low	1	0
gadolinium dtpa	low	2	0
phosphocreatine	low	1	0
thiocolchicoside	low	1	0
endothelin-1	low	1	0
vendex	medium	30	3
sphingosine kinase	low	1	0
interleukin-8	low	1	0
ascorbic acid	low	1	0
warfarin	low	1	0
brass	low	1	0
transforming growth factor alpha	low	1	0
technetium tc 99m medronate	medium	21	1
chondroitin sulfates	low	1	0
exudates	low	3	0
hypoxanthine	low	1	0

Protein Targets (1,013)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
dopamine D1 receptor	3	0	0	3
thioredoxin reductase	17	0	0	17
GLS protein	11	0	0	11
Thrombopoietin	2	0	0	2
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	7	0	0	7
cytochrome P450 2D6 isoform 1	5	0	0	5
cytochrome P450 2C19 precursor	5	0	0	5
ras-related protein Rab-9A	5	0	0	5
histone acetyltransferase KAT2A isoform 1	9	0	0	9
lethal factor (plasmid)	9	0	0	9
POU domain, class 2, transcription factor 1	0	0	0	1
Spike glycoprotein	7	0	0	7
ATP-dependent phosphofructokinase	9	0	0	9
RAR-related orphan receptor gamma	17	0	0	17
ATAD5 protein, partial	7	0	0	7
Microtubule-associated protein tau	9	0	0	9
Smad3	4	0	0	4
aldehyde dehydrogenase 1 family, member A1	16	0	0	16
thyroid stimulating hormone receptor	10	0	0	10
nuclear receptor subfamily 1, group I, member 3	10	0	0	10
progesterone receptor	11	0	0	11
EWS/FLI fusion protein	6	0	0	7
retinoic acid nuclear receptor alpha variant 1	19	0	0	19
retinoid X nuclear receptor alpha	17	0	0	17
estrogen-related nuclear receptor alpha	23	0	0	23
estrogen nuclear receptor alpha	34	0	0	34
peroxisome proliferator activated receptor gamma	14	0	0	14
aryl hydrocarbon receptor	12	0	0	12
chromobox protein homolog 1	12	0	0	12
thyroid hormone receptor beta isoform 2	18	0	0	18
peripheral myelin protein 22	7	0	0	7
cytochrome P450 3A4 isoform 1	9	0	0	9
Gamma-aminobutyric acid receptor subunit pi	9	2	1	12
ATP-binding cassette sub-family C member 3	0	15	0	15
Multidrug resistance-associated protein 4	0	15	0	16
Solute carrier family 22 member 6	0	5	0	5
Carbonic anhydrase 12	0	2	0	2
UDP-glucuronosyltransferase 1A9	0	0	0	2
Bile salt export pump	0	5	0	5
Voltage-dependent calcium channel gamma-2 subunit	8	0	0	8
Bile salt export pump	0	22	0	22
Cytochrome P450 2B1	0	0	0	1
Cytochrome P450 1A1	0	0	0	1
Carbonic anhydrase 1	0	4	0	7
Carbonic anhydrase 2	0	5	1	9
Myoglobin	0	1	0	1
Cytochrome P450 1A1	0	0	1	2
Cytochrome P450 1A2	0	2	0	3
Prostaglandin G/H synthase 1	0	7	0	8
Carbonic anhydrase 3	0	2	0	2
Cytochrome P450 3A4	0	6	1	7
Cytochrome P450 2D6	0	5	0	5
Cytochrome P450 2C9	0	7	0	7
Polyunsaturated fatty acid lipoxygenase ALOX15	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	9	2	1	12
Sulfotransferase 1A1	0	0	0	1
Gamma-aminobutyric acid receptor subunit delta	9	2	1	12
Gamma-aminobutyric acid receptor subunit gamma-2	9	2	2	13
UDP-glucuronosyltransferase 1-6	0	0	0	2
Glutamate receptor 2	8	2	1	11
Gamma-aminobutyric acid receptor subunit alpha-5	9	2	1	12
Gamma-aminobutyric acid receptor subunit alpha-3	9	2	1	12
Arachidonate 5-lipoxygenase-activating protein	0	1	0	1
UDP-glucuronosyltransferase 1A1	0	0	0	1
Carbonic anhydrase 4	0	2	0	2
Prostaglandin G/H synthase 1	0	7	0	7
Carbonic anhydrase 6	0	2	0	2
Gamma-aminobutyric acid receptor subunit gamma-1	9	2	1	12
Gamma-aminobutyric acid receptor subunit alpha-2	9	2	1	12
Gamma-aminobutyric acid receptor subunit alpha-4	9	2	1	12
Gamma-aminobutyric acid receptor subunit gamma-3	9	2	1	12
Gamma-aminobutyric acid receptor subunit alpha-6	9	2	1	12
Carbonic anhydrase 5A, mitochondrial	0	2	0	2
Prostaglandin G/H synthase 2	0	7	2	11
Carbonic anhydrase 7	0	2	0	2
Nuclear receptor ROR-gamma	8	0	0	8
Cytochrome P450 2J2	0	5	0	5
Gamma-aminobutyric acid receptor subunit alpha-1	9	2	2	13
Gamma-aminobutyric acid receptor subunit beta-3	9	2	1	12
Gamma-aminobutyric acid receptor subunit beta-2	9	2	2	13
Carbonic anhydrase 9	0	3	1	4
GABA theta subunit	9	2	1	12
Canalicular multispecific organic anion transporter 1	0	14	0	14
Carbonic anhydrase 15	0	2	0	2
Carbonic anhydrase 13	0	2	0	2
Gamma-aminobutyric acid receptor subunit epsilon	9	2	1	12
Carbonic anhydrase 14	0	2	0	2
Carbonic anhydrase 5B, mitochondrial	0	2	0	2
toxin B	0	0	0	1
caspase 7, apoptosis-related cysteine protease	4	0	0	4
glucocorticoid receptor [Homo sapiens]	19	0	0	19
pregnane X nuclear receptor	12	0	0	12
vitamin D (1,25- dihydroxyvitamin D3) receptor	15	0	0	15
caspase-3	4	0	0	4
nuclear factor erythroid 2-related factor 2 isoform 1	21	0	0	21
Alcohol dehydrogenase E chain	0	1	0	1
Alcohol dehydrogenase S chain	0	1	0	1
Cellular tumor antigen p53	15	0	0	15
Fibroblast growth factor receptor 4	0	1	0	1
Chain A, HADH2 protein	6	0	0	6
Chain B, HADH2 protein	6	0	0	6
USP1 protein, partial	10	0	0	10
NFKB1 protein, partial	4	0	0	4
cytochrome P450 family 3 subfamily A polypeptide 4	13	0	0	13
cytochrome P450 2D6	6	0	0	6
arylsulfatase A	11	0	0	11
D(1A) dopamine receptor	5	0	0	5
atrial natriuretic peptide receptor 2 precursor	4	0	0	4
serine/threonine-protein kinase mTOR isoform 1	4	0	0	4
muscarinic acetylcholine receptor M1	7	0	0	7
Solute carrier family 22 member 1	0	5	0	8
Polyunsaturated fatty acid lipoxygenase ALOX15B	4	0	0	4
Voltage-dependent L-type calcium channel subunit alpha-1F	0	1	0	1
5-hydroxytryptamine receptor 4	0	6	0	6
Albumin	0	0	4	4
High affinity nerve growth factor receptor	0	1	2	3
Aldo-keto reductase family 1 member B1	0	5	0	5
Muscarinic acetylcholine receptor M2	0	5	1	6
Muscarinic acetylcholine receptor M4	0	4	0	4
Muscarinic acetylcholine receptor M1	0	3	1	4
Muscarinic acetylcholine receptor M3	0	2	1	3
Muscarinic acetylcholine receptor M4	0	3	1	4
5-hydroxytryptamine receptor 2C	0	7	0	7
Muscarinic acetylcholine receptor M5	0	2	1	3
Muscarinic acetylcholine receptor M5	0	6	0	6
Alpha-2A adrenergic receptor	0	8	3	13
Muscarinic acetylcholine receptor M2	0	2	1	3
Muscarinic acetylcholine receptor M1	0	7	1	8
Angiotensin-converting enzyme	0	7	0	7
D(2) dopamine receptor	0	3	1	4
5-hydroxytryptamine receptor 2A	0	6	0	6
Alpha-2B adrenergic receptor	0	8	3	13
Alpha-2C adrenergic receptor	0	7	3	12
5-hydroxytryptamine receptor 1A	0	8	1	10
Muscarinic acetylcholine receptor M3	0	7	1	8
D(1A) dopamine receptor	0	3	1	4
D(1B) dopamine receptor	0	1	0	1
UDP-glucuronosyltransferase 1A4	0	0	0	1
Sodium-dependent noradrenaline transporter	0	6	1	7
Histamine H2 receptor	0	2	0	2
Alpha-1D adrenergic receptor	0	6	3	12
5-hydroxytryptamine receptor 2A	0	6	1	7
5-hydroxytryptamine receptor 2C	0	6	1	7
5-hydroxytryptamine receptor 1B	0	8	0	8
5-hydroxytryptamine receptor 1D	0	3	0	3
5-hydroxytryptamine receptor 1F	0	3	0	3
5-hydroxytryptamine receptor 2B	0	6	0	6
5-hydroxytryptamine receptor 6	0	2	0	2
Histamine H1 receptor	0	1	0	1
Sodium-dependent serotonin transporter	0	10	2	12
5-hydroxytryptamine receptor 7	0	2	0	2
5-hydroxytryptamine receptor 5A	0	2	0	2
5-hydroxytryptamine receptor 5B	0	2	0	2
Histamine H1 receptor	0	2	0	2
D(3) dopamine receptor	0	3	0	3
Sodium channel protein type 1 subunit alpha	0	1	0	1
Sodium channel protein type 4 subunit alpha	0	2	0	2
UDP-glucuronosyltransferase 1A3	0	0	0	2
5-hydroxytryptamine receptor 3A	0	2	0	2
5-hydroxytryptamine receptor 2B	0	6	1	7
Alpha-1A adrenergic receptor	0	8	3	11
Histamine H2 receptor	7	1	0	9
D(1A) dopamine receptor	3	0	0	3
5-hydroxytryptamine receptor 6	0	6	1	7
5-hydroxytryptamine receptor 7	0	4	0	4
Voltage-dependent N-type calcium channel subunit alpha-1B	0	1	0	1
Sodium channel protein type 7 subunit alpha	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	1	0	1
Sodium-dependent dopamine transporter	0	6	1	7
Potassium voltage-gated channel subfamily H member 2	0	12	0	12
Voltage-dependent L-type calcium channel subunit alpha-1S	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	2	0	2
Sodium channel protein type 5 subunit alpha	0	3	0	3
Sodium channel protein type 9 subunit alpha	0	2	0	2
Sigma non-opioid intracellular receptor 1	0	2	1	3
5-hydroxytryptamine receptor 4	0	2	0	2
Nuclear receptor subfamily 3 group C member 3	0	6	0	6
Sodium channel protein type 2 subunit alpha	0	1	0	1
Ataxin-2	11	0	0	11
Sigma non-opioid intracellular receptor 1	0	13	0	13
5-hydroxytryptamine receptor 3B	0	2	0	2
Sodium channel protein type 3 subunit alpha	0	2	0	2
Sodium channel protein type 11 subunit alpha	0	1	0	1
Sodium channel protein type 8 subunit alpha	0	1	0	1
Histamine H3 receptor	0	2	0	2
Sodium channel protein type 10 subunit alpha	0	1	0	1
glucocerebrosidase	6	0	0	6
DNA polymerase kappa isoform 1	11	0	0	11
Atrial natriuretic peptide receptor 3	0	1	0	1
Type-1A angiotensin II receptor	0	2	1	3
Type-1 angiotensin II receptor	0	0	1	1
Type-1B angiotensin II receptor	0	2	0	2
Type-1 angiotensin II receptor	0	3	3	6
Type-2 angiotensin II receptor	0	3	0	3
Type-2 angiotensin II receptor	0	2	0	2
Chain A, ADIPOCYTE LIPID-BINDING PROTEIN	0	0	1	1
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	15	0	0	15
Chain A, SERUM ALBUMIN	0	0	1	1
Chain A, SERUM ALBUMIN	0	0	1	1
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	5	0	0	5
Chain A, Beta-lactamase	5	0	0	5
Chain A, 2-oxoglutarate Oxygenase	7	0	0	7
Chain A, ATP-DEPENDENT DNA HELICASE Q1	2	0	0	2
Chain A, Cruzipain	6	0	0	6
15-lipoxygenase, partial	3	0	0	3
phosphopantetheinyl transferase	9	0	0	9
TDP1 protein	17	0	0	17
thioredoxin glutathione reductase	4	0	0	4
euchromatic histone-lysine N-methyltransferase 2	23	0	0	23
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	4	0	0	4
Bloom syndrome protein isoform 1	6	0	0	6
cellular tumor antigen p53 isoform a	6	0	0	6
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	5	0	0	5
vitamin D3 receptor isoform VDRA	8	0	0	8
ubiquitin carboxyl-terminal hydrolase 2 isoform a	3	0	0	3
nuclear receptor ROR-gamma isoform 1	5	0	0	5
lethal(3)malignant brain tumor-like protein 1 isoform I	3	0	0	3
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	2	0	0	2
caspase-1 isoform alpha precursor	3	0	0	3
lamin isoform A-delta10	17	0	0	17
Fatty-acid amide hydrolase 1	0	1	0	1
Prostaglandin G/H synthase 1	0	3	0	5
Trypsin	0	1	0	1
Coagulation factor VII	0	1	0	1
60 kDa chaperonin	0	2	0	2
60 kDa heat shock protein, mitochondrial	0	2	0	2
Aromatase	0	1	0	1
Tissue factor	0	3	0	3
Fatty acid-binding protein, adipocyte	0	1	1	2
Nuclear receptor subfamily 4 group A member 2	0	0	1	1
10 kDa heat shock protein, mitochondrial	0	2	0	2
Calmodulin	0	0	0	1
Disintegrin and metalloproteinase domain-containing protein 17	2	0	0	2
Prostaglandin G/H synthase 2	0	5	0	6
Solute carrier organic anion transporter family member 2A1	0	0	0	2
Fatty acid-binding protein 5	0	1	0	1
Fatty acid-binding protein 5	0	0	1	1
Thiosulfate sulfurtransferase	0	2	0	2
Lanosterol 14-alpha demethylase	0	1	0	1
60 kDa chaperonin	0	2	0	2
10 kDa chaperonin	0	2	0	2
Solute carrier organic anion transporter family member 1B3	0	4	0	4
Cytosolic phospholipase A2 gamma	0	2	0	2
Transient receptor potential cation channel subfamily V member 2	0	1	0	1
Solute carrier organic anion transporter family member 1B1	0	4	0	4
Chain A, Hyaluronidase, phage associated	0	1	0	1
acetylcholinesterase	8	0	0	8
GLI family zinc finger 3	18	0	0	18
AR protein	27	0	0	27
IDH1	10	0	0	10
nuclear factor erythroid 2-related factor 2 isoform 2	6	0	0	6
geminin	14	0	0	14
Polyphenol oxidase 2	0	2	0	3
Pancreatic alpha-amylase	0	2	0	2
Albumin	0	2	0	2
Urease	0	1	0	1
Prolyl 4-hydroxylase subunit alpha-1	0	0	0	1
Tyrosinase	0	2	0	2
Hyaluronate lyase	0	1	0	1
Prolyl hydroxylase EGLN2	0	0	0	1
Egl nine homolog 1	0	0	0	1
Prolyl hydroxylase EGLN3	0	0	0	1
Hypoxia-inducible factor 1-alpha inhibitor	0	0	0	1
Solute carrier family 23 member 1	0	1	0	1
Chain A, Ferritin light chain	5	0	0	5
Metabotropic glutamate receptor 6	0	1	2	4
Excitatory amino acid transporter 4	0	2	0	2
Glutamate transporter homolog	0	0	1	1
N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase	0	1	0	1
5-hydroxytryptamine receptor 1D	0	1	0	2
Glutamate receptor ionotropic, NMDA 1	0	6	1	7
Excitatory amino acid transporter 1	0	3	0	4
Excitatory amino acid transporter 2	0	3	0	4
Excitatory amino acid transporter 3	0	3	0	4
Glutamate receptor ionotropic, NMDA 2A	0	6	1	7
Glutamate receptor ionotropic, NMDA 2B	0	6	1	7
Glutamate receptor ionotropic, NMDA 2C	0	6	1	8
Metabotropic glutamate receptor 1	0	1	2	4
Metabotropic glutamate receptor 2	0	1	2	4
Carbonic anhydrase-like protein, putative	0	0	0	3
Glutamate receptor ionotropic, NMDA 2D	0	6	1	7
Glutamate receptor ionotropic, NMDA 3B	0	6	1	7
Carbonic anhydrase 4	0	0	0	1
Glutamate receptor ionotropic, NMDA 3A	0	6	1	7
regulator of G-protein signaling 4	11	0	0	11
67.9K protein	7	0	0	7
activating transcription factor 6	11	0	0	11
Gamma-aminobutyric acid type B receptor subunit 2	0	2	1	3
Gamma-aminobutyric acid type B receptor subunit 2	0	2	0	2
Gamma-aminobutyric acid type B receptor subunit 1	0	2	1	3
Gamma-aminobutyric acid type B receptor subunit 1	0	1	0	1
pregnane X receptor	6	0	0	6
farnesoid X nuclear receptor	11	0	0	11
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	13	0	0	13
nuclear receptor subfamily 1, group I, member 2	5	0	0	5
thyroid hormone receptor beta isoform a	9	0	0	9
galanin receptor type 3	0	1	0	1
Glucocorticoid receptor	0	6	0	6
Glycine receptor subunit alpha-1	0	6	0	6
Glycine receptor subunit beta	0	6	0	6
Glycine receptor subunit alpha-2	0	6	0	6
Glycine receptor subunit alpha-3	0	6	0	6
ORF73	0	0	1	1
Angiotensin-converting enzyme	0	1	0	2
B2 bradykinin receptor	0	1	0	1
B2 bradykinin receptor	0	2	1	5
B1 bradykinin receptor	0	1	0	1
Olfactory receptor 51E2	0	0	1	1
RGS12	1	0	0	1
Potassium channel subfamily K member 3	0	2	0	2
Potassium channel subfamily K member 3	0	1	0	1
Potassium channel subfamily K member 2	0	2	1	3
Potassium channel subfamily K member 9	0	1	0	1
hypoxia-inducible factor 1 alpha subunit	9	0	0	9
SMAD family member 2	7	0	0	7
SMAD family member 3	7	0	0	7
estrogen receptor 2 (ER beta)	7	0	0	7
peroxisome proliferator-activated receptor delta	10	0	0	10
thyrotropin-releasing hormone receptor	3	0	0	3
v-jun sarcoma virus 17 oncogene homolog (avian)	9	0	0	9
heat shock protein beta-1	6	0	0	6
mitogen-activated protein kinase 1	5	0	0	5
survival motor neuron protein isoform d	4	0	0	4
Caspase-2	0	0	1	1
Inositol monophosphatase 1	4	0	0	4
ATPase family AAA domain-containing protein 5	7	0	0	7
Gamma-aminobutyric acid receptor subunit pi	0	4	0	4
Gamma-aminobutyric acid receptor subunit delta	0	4	0	4
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-4	0	4	2	7
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	0	1
Neuronal acetylcholine receptor subunit beta-2	0	4	2	7
Gamma-aminobutyric acid receptor subunit alpha-1	0	4	0	4
Gamma-aminobutyric acid receptor subunit beta-1	0	4	0	4
Gamma-aminobutyric acid receptor subunit gamma-2	0	4	0	4
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-3	0	4	0	4
Translocator protein	0	1	0	1
Translocator protein	0	1	0	1
Cholecystokinin receptor type A	0	1	0	1
Gastrin/cholecystokinin type B receptor	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	4	0	4
Gamma-aminobutyric acid receptor subunit alpha-3	0	4	0	4
Gamma-aminobutyric acid receptor subunit alpha-2	0	4	0	4
Gamma-aminobutyric acid receptor subunit beta-2	0	4	0	4
Gamma-aminobutyric acid receptor subunit alpha-4	0	4	0	4
Gamma-aminobutyric acid receptor subunit epsilon	0	4	0	4
Gamma-aminobutyric acid receptor subunit alpha-6	0	4	0	4
Gamma-aminobutyric acid receptor subunit gamma-1	0	4	0	4
Gamma-aminobutyric acid receptor subunit gamma-3	0	4	0	4
Gamma-aminobutyric acid receptor subunit theta	0	4	0	4
Beta-1 adrenergic receptor	0	1	2	4
Alpha-1B adrenergic receptor	0	0	1	1
cytochrome P450 2C9 precursor	4	0	0	4
Membrane primary amine oxidase	0	1	0	1
5-hydroxytryptamine receptor 3A	0	0	1	1
Solute carrier family 22 member 3	0	4	0	4
5-hydroxytryptamine receptor 1A	0	3	0	3
Alpha-1B adrenergic receptor	0	7	2	9
Alpha-1A adrenergic receptor	0	1	1	2
D	0	3	0	3
D(3) dopamine receptor	0	2	0	2
Alpha-2B adrenergic receptor	0	5	2	7
Amine oxidase [flavin-containing] A	0	3	0	3
Alpha-2C adrenergic receptor	0	5	2	7
Alpha-2A adrenergic receptor	0	5	2	7
Alpha-1D adrenergic receptor	0	7	2	9
D(1B) dopamine receptor	0	1	0	1
Amine oxidase [flavin-containing] B	0	3	0	3
Adenosine receptor A2b	0	0	1	1
Adenosine receptor A2a	0	3	1	4
Alpha-2B adrenergic receptor	0	1	0	2
D(4) dopamine receptor	0	1	0	1
Delta-type opioid receptor	0	2	0	3
Alpha-1A adrenergic receptor	0	4	4	13
Alpha-1B adrenergic receptor	0	3	3	9
D(2) dopamine receptor	0	5	1	6
Mu-type opioid receptor	0	3	0	3
Alpha-2C adrenergic receptor	0	1	0	2
Alpha-2A adrenergic receptor	0	1	0	2
Alpha-2A adrenergic receptor	0	2	0	2
Nischarin	0	2	0	2
Solute carrier family 22 member 1	0	2	0	2
Multidrug and toxin extrusion protein 1	0	6	0	6
Nischarin	0	1	0	1
Chain A, CHIMERA OF IG KAPPA CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION	0	0	1	1
Chain B, CHIMERA OF IG GAMMA-1 CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION	0	0	1	1
Chain H, Fab M82G2, Heavy chain	0	0	1	1
Chain L, Fab M82G2, Light chain	0	0	1	1
Chain H, Fab M82g2, Heavy Chain	0	0	1	1
Chain L, Fab M82g2, Light Chain	0	0	1	1
Amyloid-beta precursor protein	0	2	0	3
Fatty acid-binding protein, heart	0	1	0	1
Muscarinic acetylcholine receptor M2	0	1	0	1
Tryptophan 5-hydroxylase 1	0	1	0	1
Liver carboxylesterase 1	0	1	0	2
Sodium-dependent dopamine transporter	0	5	0	5
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	3	0	3
Sodium-dependent serotonin transporter	0	5	0	6
Lysosomal Pro-X carboxypeptidase	0	2	0	2
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	3	0	3
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	3	0	3
Leukotriene B4 receptor 1	0	3	0	3
Sodium-dependent dopamine transporter	0	3	0	3
Leukotriene B4 receptor 2	0	2	0	2
Transporter	0	4	1	6
Luciferase	9	0	0	9
interleukin 8	7	0	0	7
endonuclease IV	5	0	0	5
PAX8	0	0	0	1
Fumarate hydratase	3	0	0	3
PPM1D protein	4	0	0	4
polyprotein	3	0	0	3
nuclear receptor subfamily 0 group B member 1	0	1	0	1
flap endonuclease 1	6	0	0	6
steroidogenic factor 1	0	1	0	1
muscleblind-like protein 1 isoform 1	4	0	0	4
neuropeptide S receptor isoform A	3	0	0	3
Interferon beta	8	0	0	8
Tubulin alpha-1A chain	0	2	1	3
Tubulin beta chain	0	2	1	3
Plasma kallikrein	0	0	0	1
Tubulin beta-4A chain	0	2	2	5
ATP-dependent translocase ABCB1	0	1	0	1
Tubulin beta chain	0	2	2	5
ATP-dependent translocase ABCB1	0	5	0	7
Tubulin alpha-3C chain	0	2	2	5
Serine/threonine-protein kinase pim-1	0	1	0	1
ATP-dependent translocase ABCB1	0	1	0	1
Tubulin alpha-1B chain	0	2	2	5
Tubulin alpha-4A chain	0	2	2	5
Tubulin beta-4B chain	0	2	2	5
Vesicular acetylcholine transporter	0	1	0	1
Tubulin beta-3 chain	0	2	2	5
Tubulin beta-2A chain	0	2	2	5
Tubulin polymerization-promoting protein	0	0	1	1
Tubulin beta-8 chain	0	2	2	5
Tubulin beta-2B chain	0	2	0	2
Tubulin alpha-3E chain	0	2	2	5
Tubulin alpha-1A chain	0	2	2	5
Similar to alpha-tubulin isoform 1	0	1	0	1
Similar to alpha-tubulin isoform 1	0	1	0	1
CREB-binding protein	1	1	0	2
Tubulin alpha-1C chain	0	2	2	5
Tubulin beta-6 chain	0	2	2	5
Tubulin beta-2B chain	0	2	2	5
Tubulin beta-1 chain	0	2	2	5
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	4	0	0	4
peripheral myelin protein 22 isoform 1	4	0	0	4
atrial natriuretic peptide receptor 1 precursor	1	0	0	1
M-phase phosphoprotein 8	2	0	0	2
Sex hormone-binding globulin	0	0	2	2
Corticosteroid-binding globulin	0	2	0	2
Potassium voltage-gated channel subfamily A member 1	0	0	1	1
TAR DNA-binding protein 43	6	0	0	6
Sodium- and chloride-dependent creatine transporter 1	0	1	0	1
Proton-coupled amino acid transporter 1	0	4	0	4
Chain A, Breast cancer type 1 susceptibility protein	1	0	0	1
Chain A, Putative fructose-1,6-bisphosphate aldolase	5	0	0	5
Chain A, JmjC domain-containing histone demethylation protein 3A	1	0	0	1
Nrf2	1	0	0	1
alkaline phosphatase, intestinal	0	1	0	1
apical membrane antigen 1, AMA1	1	0	0	1
PINK1	1	0	0	1
Parkin	2	0	0	2
bromodomain adjacent to zinc finger domain 2B	4	0	0	4
toll-like receptor 9	0	1	0	1
TPA: protein transporter TIM10	0	1	0	1
thyroid stimulating hormone receptor	8	0	0	8
Histone H2A.x	6	0	0	6
lysosomal alpha-glucosidase preproprotein	2	0	0	2
alkaline phosphatase, tissue-nonspecific isozyme isoform 1 preproprotein	0	1	0	1
hemoglobin subunit beta	1	0	0	1
polyunsaturated fatty acid lipoxygenase ALOX12	1	0	0	1
perilipin-5	0	1	0	1
intestinal alkaline phosphatase precursor	0	1	0	1
perilipin-1	0	1	0	1
potassium voltage-gated channel subfamily H member 2 isoform d	4	0	0	4
transcriptional regulator ERG isoform 3	3	0	0	3
huntingtin isoform 2	3	0	0	3
importin subunit beta-1 isoform 1	3	0	0	3
pyruvate kinase PKM isoform a	1	0	0	1
DNA polymerase beta	1	0	0	1
nuclear factor NF-kappa-B p105 subunit isoform 1	1	0	0	1
snurportin-1	3	0	0	3
histone-lysine N-methyltransferase 2A isoform 2 precursor	3	0	0	3
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	3	0	0	3
tumor susceptibility gene 101 protein	1	0	0	1
GTP-binding nuclear protein Ran isoform 1	2	0	0	2
DNA polymerase iota isoform a (long)	3	0	0	3
urokinase-type plasminogen activator precursor	2	0	0	2
plasminogen precursor	2	0	0	2
urokinase plasminogen activator surface receptor precursor	2	0	0	2
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform a	0	1	0	1
alkaline phosphatase, germ cell type preproprotein	0	1	0	1
hypothetical protein SA1422	0	1	0	1
DNA dC->dU-editing enzyme APOBEC-3F isoform a	1	0	0	1
Prostaglandin E synthase	0	2	0	2
Histone deacetylase 3	0	3	0	3
Acetylcholinesterase	0	2	0	2
Lysine-specific histone demethylase 1A	0	1	0	1
D-amino-acid oxidase	0	1	0	1
Phospholipase A2	0	1	0	1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	0	2	0	2
Integrin beta-3	4	0	1	5
Neuronal proto-oncogene tyrosine-protein kinase Src	0	1	0	1
Cholinesterase	0	3	0	3
Heme oxygenase 1	0	1	0	1
Integrin alpha-IIb	4	0	1	5
Glutathione S-transferase P	0	1	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	1
Replicase polyprotein 1ab	0	1	1	2
Replicase polyprotein 1ab	0	1	1	2
Microtubule-associated protein tau	0	1	0	2
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2	0	1	0	1
Aminopeptidase N	0	1	0	1
Aminopeptidase N	0	1	0	1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2	0	2	0	2
Glycogen synthase kinase-3 beta	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	2	0	2
Acetylcholinesterase	0	5	0	5
Heme oxygenase 2	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	1	0	1
Proteasome subunit beta type-5	0	1	0	1
17-beta-hydroxysteroid dehydrogenase type 2	0	1	0	1
Alpha-synuclein	2	1	1	4
Glycogen synthase kinase-3 beta	0	1	0	1
Caspase-7	1	0	0	1
Histone deacetylase 4	0	3	0	3
Beta-secretase 1	0	1	0	1
Guanine nucleotide-binding protein G	2	0	0	2
Cholinesterase	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1S	0	1	0	1
Lactoylglutathione lyase	0	2	0	2
Histone acetyltransferase p300	0	1	0	1
Serine/threonine-protein kinase PAK 1	0	1	0	1
Histone deacetylase 1	0	4	0	4
5-hydroxytryptamine receptor 4	0	0	1	1
Sodium/bile acid cotransporter	0	1	1	2
Nuclear factor erythroid 2-related factor 2	0	0	1	1
Thioredoxin reductase 1, cytoplasmic	0	1	0	1
Thioredoxin reductase 3	0	1	0	1
Sortase A	0	1	0	1
Histone deacetylase 7	0	3	0	3
Histone deacetylase 2	0	4	0	4
Sarcoplasmic/endoplasmic reticulum calcium ATPase 3	0	2	0	2
Cysteine protease	0	1	0	1
Polyamine deacetylase HDAC10	0	3	0	3
Histone deacetylase 11	0	3	0	3
NACHT, LRR and PYD domains-containing protein 3	0	1	0	1
Histone deacetylase 8	0	4	0	4
Thioredoxin reductase 2, mitochondrial	0	1	0	1
CDGSH iron-sulfur domain-containing protein 1	0	2	0	2
Histone deacetylase 6	0	3	0	3
Histone deacetylase 9	0	3	0	3
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	1	0	2
Histone deacetylase 5	0	3	0	3
Lymphocyte antigen 96	0	0	1	1
Beta lactamase (plasmid)	0	1	0	1
Beta-glucuronidase	0	1	0	1
Beta-glucuronidase	0	1	0	1
Glucose-6-phosphate 1-dehydrogenase	0	4	0	4
G-protein coupled bile acid receptor 1	0	0	1	1
Glucose-6-phosphate 1-dehydrogenase	0	1	0	1
NPC1-like intracellular cholesterol transporter 1	0	0	1	1
prostaglandin E2 receptor EP2 subtype	1	0	0	1
Solute carrier family 22 member 2	0	1	0	2
Solute carrier organic anion transporter family member 1A5	0	0	0	1
Prostaglandin E2 receptor EP3 subtype	0	2	0	2
Prostaglandin E2 receptor EP4 subtype	0	2	0	2
Prostaglandin E2 receptor EP1 subtype	0	2	1	3
Prostaglandin E2 receptor EP1 subtype	0	2	0	2
Prostaglandin E2 receptor EP4 subtype	0	2	1	3
Prostaglandin F2-alpha receptor	0	0	1	1
Prostaglandin E2 receptor EP4 subtype	0	1	1	2
Prostaglandin E2 receptor EP3 subtype	0	2	1	3
Prostaglandin E2 receptor EP2 subtype	0	2	1	3
Prostacyclin receptor	0	2	1	3
Solute carrier family 22 member 6	0	4	0	6
Solute carrier family 22 member 7	0	0	0	3
Prostaglandin E2 receptor EP2 subtype	0	2	0	2
Prostaglandin E2 receptor EP2 subtype	0	1	1	2
Solute carrier family 22 member 20	0	4	0	4
Solute carrier family 22 member 8	0	4	0	5
Solute carrier family 22 member 6	0	4	0	4
Solute carrier family 22 member 7	0	0	0	1
Solute carrier organic anion transporter family member 2A1	0	0	0	1
Solute carrier family 22 member 11	0	0	0	1
Solute carrier organic anion transporter family member 1B2	0	0	0	1
Solute carrier family 22 member 7	0	0	0	1
Succinyl-diaminopimelate desuccinylase	0	1	0	1
Solute carrier family 15 member 1	0	1	0	1
Solute carrier organic anion transporter family member 1A1	0	1	0	2
Angiotensin-converting enzyme	0	1	0	1
Solute carrier family 15 member 1	0	1	0	1
Angiotensin-converting enzyme 2	0	1	0	1
Endothelin-1 receptor	0	2	1	3
Genome polyprotein	0	1	1	2
chaperonin-containing TCP-1 beta subunit homolog	2	0	0	2
hypothetical protein, conserved	1	0	0	1
G	4	0	0	4
eyes absent homolog 2 isoform a	1	0	0	1
relaxin receptor 1 isoform 1	2	0	0	2
HLA class I histocompatibility antigen, B alpha chain	4	0	0	4
Flavin reductase (NADPH)	0	0	1	1
Inositol hexakisphosphate kinase 1	4	0	0	4
cytochrome P450 2C9, partial	4	0	0	4
large T antigen	0	1	0	1
Caspase-7	1	0	0	1
NPC intracellular cholesterol transporter 1 precursor	2	0	0	2
caspase-3	1	0	0	1
Sodium-dependent noradrenaline transporter	0	1	0	1
Sodium channel protein type 1 subunit alpha	0	3	0	3
Cytochrome P450 2C8	0	2	0	2
Dipeptidyl peptidase 4	0	1	0	1
Acetylcholinesterase	0	1	0	1
Potassium voltage-gated channel subfamily C member 1	0	1	0	1
Cytochrome P450 2C19	0	2	0	2
Gastrin/cholecystokinin type B receptor	0	1	0	1
Cytochrome P450 1B1	0	1	0	1
Sigma intracellular receptor 2	0	2	0	2
Sodium-dependent serotonin transporter	0	1	0	1
Transporter	0	1	0	1
Beta-2 adrenergic receptor	0	2	1	4
Sigma non-opioid intracellular receptor 1	0	3	0	3
Chain A, GLUTAMATE RECEPTOR SUBUNIT 2	0	1	0	1
Chain A, Glutamate Receptor Subunit 2	0	1	0	1
Chain B, Glutamate Receptor Subunit 2	0	1	0	1
Chain A, Slr1257 protein	0	0	1	1
Chain A, Glucosamine--fructose-6-phosphate aminotransferase [isomerizing]	0	1	0	1
glp-1 receptor, partial	2	0	0	2
beta-2 adrenergic receptor	1	0	0	1
Metabotropic glutamate receptor 8	0	2	0	2
Glutamate receptor ionotropic, NMDA 2D	0	2	0	2
Glutamate receptor ionotropic, NMDA 3B	0	2	0	2
Glutathione reductase, mitochondrial	0	2	0	2
Bifunctional aspartokinase/homoserine dehydrogenase 1	0	1	0	1
Prothrombin	0	0	1	1
ATP-citrate synthase	0	1	0	1
Glutamate receptor 1	0	2	1	3
Glutamate receptor 3	0	2	1	3
Glutamate receptor 4	0	2	1	3
Glutamate receptor ionotropic, kainate 1	0	2	1	3
Metabotropic glutamate receptor 1	0	1	1	2
Metabotropic glutamate receptor 2	0	0	1	1
Metabotropic glutamate receptor 3	0	0	1	1
Metabotropic glutamate receptor 4	0	1	1	2
Metabotropic glutamate receptor 5	0	0	1	1
Metabotropic glutamate receptor 6	0	0	1	1
Metabotropic glutamate receptor 7	0	0	1	1
Glutamate receptor ionotropic, kainate 1	0	1	1	2
Metabotropic glutamate receptor 5	0	1	1	3
Glutamate receptor ionotropic, kainate 2	0	2	1	3
Glutamate receptor 1	0	2	1	3
Glutamate receptor 2	0	2	1	3
Glutamate receptor 3	0	1	1	2
Glutamate receptor ionotropic, kainate 3	0	2	0	2
Metabotropic glutamate receptor 8	0	0	1	1
Glutamate receptor 4	0	2	1	3
Excitatory amino acid transporter 3	0	0	0	1
Glutamate racemase	0	0	0	1
Metabotropic glutamate receptor 8	0	1	1	2
Fatty-acid amide hydrolase 1	0	2	0	2
Glutamate receptor ionotropic, kainate 4	0	2	0	2
Glutamate carboxypeptidase 2	0	1	0	1
Glutamate receptor ionotropic, NMDA 1	0	3	0	3
Glutamate receptor ionotropic, NMDA 2A	0	3	0	3
Glutamate receptor ionotropic, kainate 2	0	1	1	2
Glutamate receptor ionotropic, kainate 3	0	1	0	1
Glutamate receptor ionotropic, NMDA 2B	0	3	0	3
Metabotropic glutamate receptor 7	0	1	1	3
Metabotropic glutamate receptor 3	0	1	1	3
Metabotropic glutamate receptor 4	0	1	1	3
Glutamate receptor ionotropic, NMDA 2C	0	2	0	2
Glutamate receptor ionotropic, kainate 5	0	1	0	1
Glutamate receptor ionotropic, kainate 5	0	2	0	2
Glutamate racemase	0	0	0	1
Prolyl 4-hydroxylase	0	1	0	1
Glutamate receptor ionotropic, NMDA 3A	0	2	0	2
Alpha-ketoglutarate-dependent dioxygenase FTO	0	1	0	1
Chain A, Glutamine Binding Protein	0	0	1	1
Neutral amino acid transporter A	0	3	0	3
Asc-type amino acid transporter 1	0	2	0	2
Neutral amino acid transporter B(0)	0	3	0	3
Amino acid transporter	0	3	0	3
Chain B, EUKARYOTIC TRANSLATION INITIATION FACTOR 4E	0	0	1	1
Chain A, 3-phosphoshikimate 1-carboxyvinyltransferase	0	1	0	1
Chain A, 3-phosphoshikimate 1-carboxyvinyltransferase	0	1	0	1
Glutamine synthetase	0	1	0	1
Cytochrome P450 71B1	0	1	0	2
Glutamine synthetase	0	1	0	1
2-dehydro-3-deoxyphosphooctonate aldolase	0	1	0	1
Chain A, Purine-nucleoside Phosphorylase	0	1	0	1
Chain C, Xanthine dehydrogenase/oxidase	0	0	1	1
Hypoxanthine-guanine phosphoribosyltransferase	0	0	0	1
Purine nucleoside phosphorylase	0	0	1	2
nonstructural protein 1	2	0	0	2
Acid-sensing ion channel 3	0	1	0	1
Solute carrier organic anion transporter family member 1A4	0	1	0	1
Prostaglandin G/H synthase 2	0	2	0	3
Dihydrofolate reductase	0	2	0	2
Epidermal growth factor receptor	0	2	0	2
Fatty acid-binding protein, liver	0	1	0	1
Albumin	0	3	4	7
Fatty acid-binding protein, intestinal	0	1	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	3	0	7
UDP-glucuronosyltransferase 2B7	0	1	0	3
Prostaglandin G/H synthase 1	0	2	0	2
Adenosine receptor A1	0	3	0	3
Caspase-1	0	2	0	3
Substance-P receptor	0	3	0	3
Prostaglandin G/H synthase 2	0	3	0	5
Aldo-keto reductase family 1 member C3	0	4	0	4
Caspase-3	0	2	0	2
Caspase-4	0	2	0	2
4-aminobutyrate aminotransferase, mitochondrial	0	1	0	1
Caspase-5	0	2	0	2
Caspase-9	0	2	0	2
Acid-sensing ion channel 1	0	1	0	1
Prostaglandin G/H synthase 2	0	2	0	3
Prostaglandin G/H synthase 1	0	3	0	5
Dehydrogenase/reductase SDR family member 9	0	1	0	1
Chain A, membrane-associated prostaglandin E synthase-2	0	1	0	1
Prostaglandin-H2 D-isomerase	0	1	0	1
3',5'-cyclic-AMP phosphodiesterase	0	1	0	1
Solute carrier organic anion transporter family member 2B1	0	2	0	2
Cytochrome c oxidase subunit 2	0	1	0	1
Phospholipase A2, major isoenzyme	0	1	0	1
Procathepsin L	0	1	0	1
Interleukin-8	0	1	0	1
Androgen receptor	0	0	1	1
Aldo-keto reductase family 1 member B1	0	2	0	2
Aldo-keto reductase family 1 member B1	0	1	0	1
Aldo-keto reductase family 1 member C4	0	2	0	2
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Thromboxane-A synthase	0	1	0	1
Serum paraoxonase/arylesterase 1	0	1	0	1
Indoleamine 2,3-dioxygenase 1	0	1	0	1
Nitric oxide synthase, inducible	0	2	0	2
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Multidrug resistance-associated protein 1	0	1	0	1
Bifunctional epoxide hydrolase 2	0	1	0	1
Peroxisome proliferator-activated receptor gamma	0	0	1	1
Sodium- and chloride-dependent betaine transporter	0	1	0	1
C-X-C chemokine receptor type 3	0	1	0	1
Aldo-keto reductase family 1 member C2	0	2	0	2
Prostaglandin D2 receptor	0	2	0	2
Solute carrier organic anion transporter family member 1A3	0	1	0	1
Aldo-keto reductase family 1 member C1	0	2	0	2
Uracil nucleotide/cysteinyl leukotriene receptor	0	1	0	1
Rho-associated protein kinase 2	0	1	0	1
Nicotinate phosphoribosyltransferase	0	2	0	2
Dehydrogenase/reductase SDR family member 9	0	1	0	1
P2Y purinoceptor 12	0	1	0	1
Prostaglandin D2 receptor 2	0	1	1	2
Sodium channel protein type 2 subunit alpha	0	2	0	2
Sodium channel protein type 3 subunit alpha	0	2	0	2
Potassium voltage-gated channel subfamily A member 5	0	1	0	1
Potassium voltage-gated channel subfamily D member 2	0	1	0	1
Potassium channel subfamily K member 18	0	1	0	1
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Androgen receptor	0	2	0	2
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Rap guanine nucleotide exchange factor 4	1	0	0	1
Solute carrier family 22 member 8	0	1	0	1
Hormone-sensitive lipase	0	1	0	1
Neutrophil elastase	0	1	0	1
Nitric oxide synthase, endothelial	0	1	0	1
Nitric oxide synthase, endothelial	0	1	0	1
Nitric oxide synthase, brain	0	1	0	1
Nitric oxide synthase, inducible	0	1	0	1
Collagenase 3	0	1	0	1
5-hydroxytryptamine receptor 3E	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-4	0	2	1	3
Transient receptor potential cation channel subfamily A member 1	0	0	1	1
5-hydroxytryptamine receptor 3B	0	1	0	1
Acetylcholine receptor subunit alpha	0	2	1	3
Acetylcholine receptor subunit alpha	0	2	1	3
Acetylcholine receptor subunit beta	0	2	1	3
Acetylcholine receptor subunit gamma	0	2	1	3
Acetylcholine receptor subunit delta	0	2	1	3
Neuronal acetylcholine receptor subunit alpha-3	0	2	2	5
Acetylcholine receptor subunit gamma	0	2	1	3
Neuronal acetylcholine receptor subunit alpha-4	0	1	0	1
Acetylcholine receptor subunit beta	0	2	1	3
Cytochrome P450 2A6	0	3	1	4
Neuronal acetylcholine receptor subunit alpha-2	0	2	2	5
Neuronal acetylcholine receptor subunit beta-3	0	2	2	5
Neuronal acetylcholine receptor subunit beta-4	0	2	2	5
Translocator protein	0	1	0	1
Neuronal acetylcholine receptor subunit beta-2	0	2	1	3
Neuronal acetylcholine receptor subunit alpha-5	0	2	2	5
Cytochrome P450 2A5	0	1	0	1
Acetylcholine receptor subunit beta-like 2	0	2	0	2
Neuronal acetylcholine receptor subunit alpha-5	0	0	1	1
Neuronal acetylcholine receptor subunit beta-4	0	2	1	3
Muscarinic acetylcholine receptor M4	0	1	1	3
Neuronal acetylcholine receptor subunit alpha-3	0	2	1	3
Delta-type opioid receptor	0	2	0	2
Mu-type opioid receptor	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-7	0	2	2	4
Neuronal acetylcholine receptor subunit alpha-6	0	2	2	5
Neuronal acetylcholine receptor subunit alpha-9	0	2	2	5
Neuronal acetylcholine receptor subunit alpha-4	0	2	1	3
5-hydroxytryptamine receptor 3A	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-7	0	2	0	2
Acetylcholine-binding protein	0	1	1	2
Acetylcholine receptor subunit epsilon	0	0	1	1
Neuronal acetylcholine receptor subunit beta-3	0	1	1	2
Neuronal acetylcholine receptor subunit alpha-7	0	2	2	5
Acetylcholine receptor subunit delta	0	2	1	3
Neuronal acetylcholine receptor subunit alpha-2	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-6	0	1	1	2
Cytochrome P450 2A13	0	1	1	2
Neuronal acetylcholine receptor subunit alpha-5	0	2	0	2
Liver carboxylesterase B-1	0	1	0	1
5-hydroxytryptamine receptor 3D	0	1	0	1
Transient receptor potential cation channel subfamily A member 1	0	0	1	1
Neuronal acetylcholine receptor subunit beta-3	0	2	0	2
Neuronal acetylcholine receptor subunit beta-4	0	2	0	2
Neuronal acetylcholine receptor subunit alpha-3	0	2	0	2
Soluble acetylcholine receptor	0	1	0	1
5-hydroxytryptamine receptor 3C	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-2	0	2	0	2
Neuronal acetylcholine receptor subunit beta-2	0	2	1	3
Neuronal acetylcholine receptor subunit alpha-10	0	2	2	5
Solute carrier family 22 member 2	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-6	0	2	0	2
Integrin beta	0	0	1	1
Glycoprotein IIb	0	0	1	1
Vasopressin V2 receptor	0	1	1	2
Oxytocin receptor	0	2	2	4
Vasopressin V1a receptor	0	1	0	1
Vasopressin V1a receptor	0	3	2	5
Vasopressin V1b receptor	0	1	1	2
Vasopressin V1b receptor	0	1	0	1
Oxytocin receptor	0	1	0	1
Oxytocin receptor	0	0	1	1
Vasopressin V2 receptor	0	1	0	1
vasopressin V1b receptor	1	0	0	1
cGMP-dependent 3',5'-cyclic phosphodiesterase	0	1	0	1
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A	0	1	0	1
cGMP-specific 3',5'-cyclic phosphodiesterase	0	1	0	1
Tumor necrosis factor	0	1	0	1
Adenosine receptor A2b	0	1	0	1
Chitotriosidase-1	0	2	1	3
cGMP-inhibited 3',5'-cyclic phosphodiesterase A	0	1	0	1
Endochitinase B1	0	2	1	3
Chain A, Immunoglobulin	0	0	1	1
Chain B, Immunoglobulin	0	0	1	1
Muscarinic acetylcholine receptor M1	0	0	1	2
Cytochrome P450 2B6	0	1	0	1
Kappa-type opioid receptor	0	0	0	1
Mu-type opioid receptor	0	0	0	1
Cholinesterase	0	1	0	1
Muscarinic acetylcholine receptor M5	0	0	1	2
Muscarinic acetylcholine receptor M3	0	0	1	2
Muscarinic acetylcholine receptor M2	0	0	1	2
alpha-galactosidase	1	0	0	1
interferon gamma precursor	0	0	0	1
histone deacetylase 9 isoform 3	1	0	0	1
Alpha-1A adrenergic receptor	0	1	1	2
Beta-casein	0	1	0	1
Interstitial collagenase	0	1	0	1
Matrix metalloproteinase-9	0	1	0	1
Ribosyldihydronicotinamide dehydrogenase [quinone]	0	1	0	1
Alpha-1B adrenergic receptor	0	1	0	1
Alpha-2A adrenergic receptor	0	1	0	1
Alpha-mannosidase 2C1	0	0	1	1
D(4) dopamine receptor	0	1	0	1
Bromodomain-containing protein 2	0	2	0	2
5-hydroxytryptamine receptor 1B	0	3	1	4
3-oxo-5-alpha-steroid 4-dehydrogenase 2	0	1	0	1
Type-1 angiotensin II receptor	0	1	0	1
Multidrug and toxin extrusion protein 2	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Beta-2 adrenergic receptor	0	2	1	3
Beta-1 adrenergic receptor	0	2	1	3
Adenosine receptor A3	0	1	1	2
Beta-2 adrenergic receptor	0	2	0	3
Beta-3 adrenergic receptor	0	2	1	3
Beta-1 adrenergic receptor	0	2	1	4
Beta-3 adrenergic receptor	0	2	0	2
Adenosine receptor A2a	0	1	1	2
Neuromedin-K receptor	0	0	1	1
Cholecystokinin receptor type A	0	1	1	2
5-hydroxytryptamine receptor 7	0	1	1	2
Beta-1 adrenergic receptor	0	1	0	1
Mu-type opioid receptor	0	1	1	2
Delta-type opioid receptor	0	1	1	2
Kappa-type opioid receptor	0	1	1	2
Beta-2 adrenergic receptor	0	1	0	1
Nuclear receptor subfamily 2 group E member 1	0	0	2	2
Chain A, dATP pyrophosphohydrolase	0	1	0	1
Chain A, Adenylate cyclase type 5	0	1	0	1
Chain B, Adenylate cyclase type 2	0	1	0	1
Carbonic anhydrase	0	1	0	1
Estrogen receptor beta	0	0	0	1
Inhibitor of nuclear factor kappa-B kinase subunit beta	0	0	0	1
5'-AMP-activated protein kinase subunit beta-2	0	0	0	1
Polymerase acidic protein	0	0	1	1
Stromelysin-1	0	0	1	1
Tyrosine-protein phosphatase YopH	0	1	0	1
High mobility group protein B1	0	0	1	1
Prolyl 4-hydroxylase subunit alpha-1	0	1	0	1
Tyrosine-protein phosphatase non-receptor type 1	0	1	0	3
Estrogen receptor	0	0	0	1
Cystathionine gamma-lyase	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-1	0	0	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-2	0	0	0	1
Xanthine dehydrogenase/oxidase	0	1	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-1	0	0	0	1
Carbonic anhydrase	0	1	0	1
Ubiquitin-like domain-containing CTD phosphatase 1	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-3	0	0	0	1
5'-AMP-activated protein kinase subunit gamma-2	0	0	0	1
5'-AMP-activated protein kinase subunit beta-1	0	0	0	1
Pyruvate kinase PKM	0	0	1	1
Substance-P receptor	0	2	0	2
Neuromedin-K receptor	0	0	1	1
Substance-K receptor	0	1	1	2
Substance-K receptor	0	2	0	2
Substance-P receptor	0	2	1	3
Neuromedin-K receptor	0	1	1	2
Substance-K receptor	0	1	0	1
Substance-K receptor	0	1	0	1
Growth hormone secretagogue receptor type 1	0	0	1	1
Mas-related G-protein coupled receptor member X2	0	0	1	1
Chain A, MALTOPORIN	0	0	1	1
Chain B, MALTOPORIN	0	0	1	1
GALC protein	1	0	0	1
Sodium- and chloride-dependent taurine transporter	0	1	0	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Solute carrier family 2, facilitated glucose transporter member 9	0	1	1	2
Guanine deaminase	0	1	0	1
Cocaine esterase	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
Aldo-keto reductase family 1 member B7	0	1	0	1
NAD-dependent protein deacylase sirtuin-5, mitochondrial	0	1	0	1
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	1	0	0	1
Proprotein convertase subtilisin/kexin type 7	0	1	0	1
Vitamin K epoxide reductase complex subunit 1-like protein 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1	0	1	0	1
Protease	0	1	0	1
Vitamin K epoxide reductase complex subunit 1-like protein 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1	0	2	0	2
streptokinase A precursor	0	0	1	1
twin arginine protein translocation system - TatA protein	0	0	0	1
30S ribosomal protein S6	0	1	0	1
30S ribosomal protein S7	0	1	0	1
50S ribosomal protein L15	0	1	0	1
50S ribosomal protein L10	0	1	0	1
50S ribosomal protein L11	0	1	0	1
50S ribosomal protein L7/L12	0	1	0	1
50S ribosomal protein L19	0	1	0	1
50S ribosomal protein L1	0	1	0	1
50S ribosomal protein L20	0	1	0	1
50S ribosomal protein L27	0	1	0	1
50S ribosomal protein L28	0	1	0	1
50S ribosomal protein L29	0	1	0	1
50S ribosomal protein L31	0	1	0	1
50S ribosomal protein L31 type B	0	1	0	1
50S ribosomal protein L32	0	1	0	1
50S ribosomal protein L33	0	1	0	1
50S ribosomal protein L34	0	1	0	1
50S ribosomal protein L35	0	1	0	1
50S ribosomal protein L36	0	1	0	1
30S ribosomal protein S10	0	1	0	1
30S ribosomal protein S11	0	1	0	1
30S ribosomal protein S12	0	1	0	1
30S ribosomal protein S13	0	1	0	1
30S ribosomal protein S16	0	1	0	1
30S ribosomal protein S18	0	1	0	1
30S ribosomal protein S19	0	1	0	1
30S ribosomal protein S20	0	1	0	1
30S ribosomal protein S2	0	1	0	1
30S ribosomal protein S3	0	1	0	1
30S ribosomal protein S4	0	1	0	1
30S ribosomal protein S5	0	1	0	1
30S ribosomal protein S8	0	1	0	1
30S ribosomal protein S9	0	1	0	1
50S ribosomal protein L13	0	1	0	1
50S ribosomal protein L14	0	1	0	1
50S ribosomal protein L16	0	1	0	1
50S ribosomal protein L23	0	1	0	1
30S ribosomal protein S15	0	1	0	1
50S ribosomal protein L17	0	1	0	1
50S ribosomal protein L21	0	1	0	1
50S ribosomal protein L30	0	1	0	1
50S ribosomal protein L6	0	1	0	1
30S ribosomal protein S14	0	1	0	1
30S ribosomal protein S17	0	1	0	1
30S ribosomal protein S1	0	1	0	1
50S ribosomal protein L18	0	1	0	1
50S ribosomal protein L2	0	1	0	1
50S ribosomal protein L3	0	1	0	1
50S ribosomal protein L24	0	1	0	1
50S ribosomal protein L4	0	1	0	1
50S ribosomal protein L22	0	1	0	1
50S ribosomal protein L5	0	1	0	1
30S ribosomal protein S21	0	1	0	1
50S ribosomal protein L25	0	1	0	1
50S ribosomal protein L36 2	0	1	0	1
Protein-arginine deiminase type-4	0	1	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Cumulative Trauma Disorders

Synonyms(10)

Research Excerpts

Overview

Treatment

Research

Studies (420)

Protein Targets (1,013)

Cumulative Trauma Disorders

Synonyms(10)

Research Excerpts

Overview

Treatment

Research

Studies (420)

Drugs Studied (128)

Protein Targets (1,013)