Ebstein Anomaly

A congenital heart defect characterized by downward or apical displacement of the TRICUSPID VALVE, usually with the septal and posterior leaflets being attached to the wall of the RIGHT VENTRICLE. It is characterized by a huge RIGHT ATRIUM and a small and less effective right ventricle.

Synonyms(4)

Synonym
Ebstein Anomaly
Familial Ebstein's Anomaly
Ebstein's Anomaly
Ebstein's Malformation

Research Excerpts

Overview

Excerpt	Reference
"Ebstein's anomaly is an uncommon congenital cardiac defect which is associated with cyanosis and arrhythmias."	( Groves, ER; Groves, JB, 1995)
"Ebstein's anomaly is a rare congenital cardiac anomaly showing significant clinical manifestations with a high mortality rate in the neonatal period."	( Hayasaka, K; Komatsu, H; Nakasato, M; Sato, S; Suzuki, H, 1997)
"Ebstein anomaly is a rare tricuspid valve anomaly."	( Chang, CC; Hsieh, YY; Lee, CC; Tsai, CH; Tsai, HD; Yeh, LS, 1998)
"Ebstein's anomaly is defined as the significant apical displacement of the part of the tricuspid valve causing significant tricuspid regurgitation and reduction of the functional right ventricle."	( Chmara, E; Cieśliński, A; Gwizdała, A; Katarzyński, S; Oko-Sarnowska, Z; Siniawski, A; Straburzyńska-Migaj, E; Szyszka, A; Trojnarska, O, 2006)
"Ebstein's anomaly is a rare congenital cardiac defect associated with both displacement and incompetence of the tricuspid valve."	( Macfarlane, AJ; Moise, S; Smith, D, 2007)
"Ebstein's anomaly is a rare congenital heart defect."	( de Zorzi, A; Del Pasqua, A; Rinelli, G; Sanders, SP, 2008)
"Ebstein's anomaly is a rare congenital malformation of the tricuspid valve, often associated with Wolff-Parkinson-White (WPW) syndrome."	( Kawahito, S; Kawano, H; Kitahata, H; Nakamura, T; Okada, T; Oshita, S, 2009)
"Ebstein's anomaly is a rare congenital cardiac abnormality, associated with cyanosis and arrhythmia."	( Aggarwal, N; Chopra, S; Keepanasseril, A; Rohilla, M; Suri, V; Vijayvergiya, R, 2010)
"Ebstein anomaly is a rare congenital heart disease that has been described in domestic dogs, a meerkat, a pygmy goat, and a lion."	( Habara, T; Hirata, S; Komai, H; Nishimura, S; Shimada, T; Shimamura, S; Shiota, Y; Takagi, N; Tani, H, 2017)
"Ebstein's anomaly is a rare congenital heart disease characterized by apical displacement of the septal and posterior tricuspid valve leaflets."	( Amiya, E; Fujiu, K; Hatano, M; Kojima, T; Komuro, I; Numata, G; Watanabe, M, 2017)
"Ebstein anomaly is a congenital heart defect with a low prevalence and high mortality in the early stages of life."	( Manotas, H; Olivella, A; Payán-Gómez, C; Piñeros, JG, 2020)

Context

Excerpt	Reference
"Some fetuses with Ebstein's anomaly have concurrent severe cardiac function impairment, which results in hydrops fetalis."	( Chang, CC; Hsieh, YY; Lee, CC; Tsai, CH; Tsai, HD; Yeh, LS, 1998)

Treatment

Excerpt	Reference
"Prenatally diagnosed Ebstein's anomaly with tricuspid valve dysplasia (EA/TVD) is a rare and high-risk congenital heart malformation with limited effective treatments."	( Kraus, E; Lannaman, K; Powel, JE; Reddy, C, 2022)

Research

Studies (107)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	45 (42.06)	23.3326
1990's	11 (10.28)	12.5806
2000's	21 (19.63)	18.1394
2010's	20 (18.69)	28.8240
2020's	10 (9.35)	9.53

Drug	Relationship Strength	Studies	Trials
hydrogen	low	1	0
nitrous oxide	low	1	0
urea	low	1	0
hydroxyindoleacetic acid	low	1	0
amiodarone	low	2	0
aspirin	low	1	0
bupivacaine	low	1	0
disopyramide	low	1	0
fentanyl	low	1	0
furosemide	low	3	0
gentamicin	low	1	0
glutaral	low	1	0
ibuprofen	low	1	0
indomethacin	low	5	0
isoproterenol	low	1	0
midazolam	low	1	0
phenobarbital	low	1	0
procainamide	low	2	0
procaine	low	1	0
propafenone	low	1	0
propofol	low	1	0
propranolol	low	3	0
sevoflurane	low	1	0
dextroamphetamine	low	1	0
spironolactone	low	1	0
prednisone	low	2	0
isosorbide dinitrate	low	1	0
lithium carbonate	low	4	0
carbonates	low	1	0
platinum	low	1	0
silver	low	1	0
tantalum	low	1	0
technetium	low	5	0
titanium	low	1	0
gadolinium	low	2	0
gold	low	1	0
remifentanil	low	1	0
adenosine	medium	3	1
cephalosporin c	low	1	0
fibrinogen	low	2	0
landiolol	low	1	0
mt 0703	low	1	0
glycogen	low	1	0
quinidine	low	2	0
imidazolidines	low	1	0
arginine vasopressin	low	1	0
digoxin	low	10	0
nadp	low	1	0
lithium	low	15	0
nitrogen dioxide	low	1	0
alprostadil	low	4	0
enalapril	low	1	0
imidapril	low	1	0
gadolinium dtpa	low	1	0
enerbol	low	2	0
nad	low	1	0
cardiovascular agents	low	2	0
piperidines	low	1	0
natriuretic peptide, brain	medium	4	1
ascorbic acid	low	1	0
sildenafil citrate	low	1	0

Protein Targets (752)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
5-hydroxytryptamine receptor 2C	0	1	2	3
5-hydroxytryptamine receptor 2A	0	1	2	3
5-hydroxytryptamine receptor 1A	0	5	3	9
5-hydroxytryptamine receptor 1B	0	5	2	7
5-hydroxytryptamine receptor 1D	0	1	2	3
5-hydroxytryptamine receptor 1F	0	1	2	3
5-hydroxytryptamine receptor 2B	0	1	2	3
5-hydroxytryptamine receptor 6	0	0	2	2
Sodium-dependent serotonin transporter	0	6	2	8
Sodium-dependent serotonin transporter	0	2	1	3
5-hydroxytryptamine receptor 7	0	0	2	2
5-hydroxytryptamine receptor 5A	0	0	2	2
5-hydroxytryptamine receptor 5B	0	0	2	2
5-hydroxytryptamine receptor 3A	0	0	2	2
5-hydroxytryptamine receptor 4	0	0	2	2
5-hydroxytryptamine receptor 3B	0	0	2	2
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	7	0	0	7
Chain A, Membrane lipoprotein tmpC	0	0	1	1
Chain A, Membrane lipoprotein tmpC	0	0	1	1
Chain A, Membrane lipoprotein tmpC	0	0	1	1
Chain A, Structure of PAE2307 in complex with adenosine	0	0	1	1
Chain B, Structure of PAE2307 in complex with adenosine	0	0	1	1
Chain A, ADENOSINE RECEPTOR A2A	0	1	0	1
Chain A, ADENOSINE RECEPTOR A2A	0	1	0	1
Chain A, tRNA (guanine-N(1)-)-methyltransferase	0	0	1	1
Chain A, Uncharacterized protein MJ0883	0	0	1	1
AR protein	21	0	0	21
signal transducer and activator of transcription 6, interleukin-4 induced	1	0	0	1
regulator of G-protein signaling 4	8	0	0	8
glucocorticoid receptor [Homo sapiens]	16	0	0	16
retinoid X nuclear receptor alpha	10	0	0	10
estrogen nuclear receptor alpha	24	0	0	24
NPYLR7B	0	0	3	3
arylsulfatase A	4	0	0	4
IDH1	8	0	0	8
Histone H2A.x	8	0	0	8
glycogen synthase kinase-3 beta isoform 1	0	0	1	1
mitogen-activated protein kinase 1	4	0	0	4
flap endonuclease 1	3	0	0	3
nuclear receptor ROR-gamma isoform 1	6	0	0	6
peripheral myelin protein 22	10	0	0	10
survival motor neuron protein isoform d	4	0	0	4
high affinity choline transporter 1 isoform a	0	1	0	1
Sodium/nucleoside cotransporter 1	0	2	0	2
Calcium dependent protein kinase	0	1	0	1
Mitogen-activated protein kinase kinase kinase 7	0	0	1	1
Sodium/nucleoside cotransporter 2	0	2	0	2
Voltage-dependent calcium channel gamma-2 subunit	5	0	0	5
Rap guanine nucleotide exchange factor 3	3	0	0	3
Purine nucleoside phosphorylase	0	1	0	1
Epidermal growth factor receptor	0	4	0	4
Phosphoglycerate kinase 1	0	1	0	1
Adenosine deaminase	0	0	0	1
Avidin	0	0	1	1
Adenosine deaminase	0	0	0	1
Glyceraldehyde-3-phosphate dehydrogenase	0	2	0	2
Receptor tyrosine-protein kinase erbB-2	0	2	0	2
Insulin receptor	0	0	0	1
Phosphoglycerate kinase 2	0	1	0	1
Heat shock protein HSP 90-alpha	0	1	1	2
Platelet-derived growth factor receptor beta	0	0	0	1
Adenosine receptor A3	0	5	3	9
Heat shock 70 kDa protein 1A	0	1	0	1
Heat shock cognate 71 kDa protein	0	0	1	1
Fibroblast growth factor receptor 1	0	0	0	1
Inosine-5'-monophosphate dehydrogenase 2	0	1	0	1
Endoplasmin	0	1	1	2
Glutamate receptor 2	5	0	0	5
Inosine-5'-monophosphate dehydrogenase 1	0	1	0	1
Fibroblast growth factor receptor 2	0	0	0	1
Fibroblast growth factor receptor 4	0	0	0	1
Fibroblast growth factor receptor 3	0	0	0	1
Streptavidin	0	0	1	1
Adenosylhomocysteinase	0	0	0	1
Adenosine receptor A1	0	4	1	5
Adenosine receptor A3	0	1	0	1
Adenosine receptor A2a	0	2	3	6
Adenosine receptor A2b	0	0	1	2
Adenosine receptor A2b	0	1	1	2
Adenylate kinase 2, mitochondrial	0	1	0	1
Adenosine receptor A1	0	3	2	6
Adenosine receptor A2a	0	4	1	5
Adenylate kinase isoenzyme 1	0	1	0	1
Phosphatidylinositol 4-kinase alpha	0	2	0	3
Adenosine receptor A1	0	1	1	2
Adenosine kinase	0	0	0	1
Adenosine deaminase	0	0	0	1
Equilibrative nucleoside transporter 2	0	2	0	2
Phosphatidylinositol 4-kinase type 2-beta	0	2	0	3
Histone-lysine N-methyltransferase, H3 lysine-79 specific	0	1	0	1
Equilibrative nucleoside transporter 1	0	4	0	4
Phosphatidylinositol 4-kinase type 2-alpha	0	2	0	3
Solute carrier family 28 member 3	0	2	0	2
Adenosine kinase	0	1	0	2
Phosphatidylinositol 4-kinase beta	0	2	0	3
5-methylthioadenosine/S-adenosylhomocysteine deaminase	0	0	0	1
Adenosine transporter 1	0	0	0	1
TDP1 protein	14	0	0	14
peroxisome proliferator activated receptor gamma	10	0	0	10
ATP-binding cassette sub-family C member 3	0	14	0	14
Multidrug resistance-associated protein 4	0	14	0	16
Bile salt export pump	0	22	0	22
Cellular tumor antigen p53	13	0	0	13
Thromboxane-A synthase	0	2	0	2
Prostaglandin E2 receptor EP3 subtype	0	3	0	3
Prostaglandin E2 receptor EP4 subtype	0	3	1	4
Prostaglandin E2 receptor EP1 subtype	0	3	0	3
Prostacyclin receptor	0	3	2	5
Nuclear receptor subfamily 4 group A member 2	0	0	1	1
Solute carrier organic anion transporter family member 2A1	0	1	0	3
Nuclear receptor subfamily 4 group A member 2	0	0	1	1
Nuclear receptor subfamily 4 group A member 2	0	0	1	1
Prostaglandin E2 receptor EP2 subtype	0	3	1	4
Canalicular multispecific organic anion transporter 1	0	14	0	14
Solute carrier organic anion transporter family member 2A1	0	0	0	2
Solute carrier organic anion transporter family member 2B1	0	1	0	1
Solute carrier organic anion transporter family member 3A1	0	0	0	1
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	6	0	0	6
acetylcholinesterase	4	0	0	4
phosphopantetheinyl transferase	2	0	0	2
hypoxia-inducible factor 1 alpha subunit	4	0	0	4
RAR-related orphan receptor gamma	12	0	0	12
SMAD family member 2	7	0	0	7
ATAD5 protein, partial	3	0	0	3
Fumarate hydratase	4	0	0	4
USP1 protein, partial	7	0	0	7
NFKB1 protein, partial	4	0	0	4
PPM1D protein	3	0	0	3
SMAD family member 3	7	0	0	7
Thrombopoietin	2	0	0	2
caspase 7, apoptosis-related cysteine protease	3	0	0	3
aldehyde dehydrogenase 1 family, member A1	10	0	0	10
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	6	0	0	6
thyroid stimulating hormone receptor	9	0	0	9
estrogen receptor 2 (ER beta)	8	0	0	8
nuclear receptor subfamily 1, group I, member 3	10	0	0	10
progesterone receptor	9	0	0	9
EWS/FLI fusion protein	8	0	0	8
retinoic acid nuclear receptor alpha variant 1	14	0	0	14
estrogen-related nuclear receptor alpha	16	0	0	16
farnesoid X nuclear receptor	9	0	0	9
pregnane X nuclear receptor	12	0	0	12
G	5	0	0	5
cytochrome P450 2D6	7	0	0	7
polyprotein	4	0	0	4
peroxisome proliferator-activated receptor delta	7	0	0	7
caspase-3	3	0	0	3
euchromatic histone-lysine N-methyltransferase 2	14	0	0	14
thyroid stimulating hormone receptor	6	0	0	6
v-jun sarcoma virus 17 oncogene homolog (avian)	8	0	0	8
cytochrome P450 2D6 isoform 1	4	0	0	4
cellular tumor antigen p53 isoform a	2	0	0	2
cytochrome P450 2C9 precursor	4	0	0	4
D(1A) dopamine receptor	5	0	0	5
chromobox protein homolog 1	6	0	0	6
thyroid hormone receptor beta isoform a	7	0	0	7
potassium voltage-gated channel subfamily H member 2 isoform d	8	0	0	8
thyroid hormone receptor beta isoform 2	15	0	0	15
heat shock protein beta-1	4	0	0	4
huntingtin isoform 2	1	0	0	1
serine/threonine-protein kinase mTOR isoform 1	4	0	0	4
nuclear factor erythroid 2-related factor 2 isoform 1	15	0	0	15
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	4	0	0	4
urokinase-type plasminogen activator precursor	3	0	0	3
plasminogen precursor	3	0	0	3
urokinase plasminogen activator surface receptor precursor	3	0	0	3
geminin	13	0	0	13
cytochrome P450 3A4 isoform 1	4	0	0	4
muscarinic acetylcholine receptor M1	6	0	0	6
lethal factor (plasmid)	6	0	0	6
lamin isoform A-delta10	12	0	0	12
Gamma-aminobutyric acid receptor subunit pi	4	3	2	9
Polyunsaturated fatty acid lipoxygenase ALOX15B	2	0	0	2
Voltage-dependent L-type calcium channel subunit alpha-1C	0	3	0	3
Solute carrier organic anion transporter family member 1A4	0	4	0	5
Voltage-dependent L-type calcium channel subunit alpha-1F	0	4	0	4
5-hydroxytryptamine receptor 4	0	8	0	8
Lysine-specific demethylase PHF2	0	1	0	1
Interferon beta	7	0	0	7
HLA class I histocompatibility antigen, B alpha chain	5	0	0	5
Thyroid hormone receptor alpha	0	1	0	1
Integrin beta-3	2	1	0	3
Tyrosine-protein kinase Fyn	0	1	0	1
ATP-dependent translocase ABCB1	0	4	0	4
Aldo-keto reductase family 1 member B1	0	6	0	6
Muscarinic acetylcholine receptor M2	0	3	1	4
Muscarinic acetylcholine receptor M4	0	2	0	2
ATP-dependent translocase ABCB1	0	14	2	18
Integrin alpha-IIb	2	1	0	3
Beta-1 adrenergic receptor	0	8	2	10
Muscarinic acetylcholine receptor M5	0	2	0	2
Alpha-2A adrenergic receptor	0	3	2	6
Cytochrome P450 2C8	0	2	0	2
Thyroid hormone receptor alpha	0	1	0	1
Thyroid hormone receptor beta	0	1	0	1
Muscarinic acetylcholine receptor M1	0	3	1	4
Beta-3 adrenergic receptor	0	7	2	9
D(2) dopamine receptor	0	5	1	6
Androgen receptor	0	4	0	5
Gamma-aminobutyric acid receptor subunit beta-1	4	3	2	9
Alpha-1B adrenergic receptor	0	5	1	6
Lethal factor	0	1	0	1
Alpha-2B adrenergic receptor	0	2	2	5
Thyroid hormone receptor beta	0	1	0	1
Gamma-aminobutyric acid receptor subunit delta	4	3	2	9
Gamma-aminobutyric acid receptor subunit gamma-2	4	3	2	9
Gamma-aminobutyric acid receptor subunit alpha-5	4	3	2	9
Gamma-aminobutyric acid receptor subunit alpha-3	4	3	2	9
Muscarinic acetylcholine receptor M3	0	3	1	4
ATP-dependent translocase ABCB1	0	4	0	4
Substance-K receptor	0	2	0	2
D(1A) dopamine receptor	0	4	1	5
D(4) dopamine receptor	0	4	0	4
Gamma-aminobutyric acid receptor subunit gamma-1	4	3	2	9
Gamma-aminobutyric acid receptor subunit alpha-2	4	3	2	9
Carnitine O-palmitoyltransferase 2, mitochondrial	0	1	0	1
Sodium-dependent noradrenaline transporter	0	8	1	9
Histamine H2 receptor	0	2	0	2
Endothelin-1 receptor	0	3	1	4
5-hydroxytryptamine receptor 2A	0	6	1	7
5-hydroxytryptamine receptor 2C	0	8	1	9
Gamma-aminobutyric acid receptor subunit alpha-4	4	3	2	9
Gamma-aminobutyric acid receptor subunit gamma-3	4	3	2	9
Lysine-specific demethylase 5A	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	4	3	2	9
B2 bradykinin receptor	0	2	0	2
Melanocortin receptor 4	0	2	0	2
C-8 sterol isomerase	0	1	0	1
Melanocortin receptor 5	0	2	0	2
Mu-type opioid receptor	0	7	3	11
D(3) dopamine receptor	0	4	0	4
Sodium channel protein type 1 subunit alpha	0	2	0	2
Sodium channel protein type 4 subunit alpha	0	1	0	1
Squalene synthase	0	1	0	1
Delta-type opioid receptor	0	7	2	10
Kappa-type opioid receptor	0	7	3	11
5-hydroxytryptamine receptor 2B	0	8	1	9
C-C chemokine receptor type 2	0	2	0	2
Melanocortin receptor 3	0	2	0	2
Alpha-1A adrenergic receptor	0	5	1	6
Histamine H2 receptor	4	0	1	5
D(1A) dopamine receptor	3	0	0	3
5-hydroxytryptamine receptor 6	0	6	1	7
Carnitine O-palmitoyltransferase 1, liver isoform	0	1	0	1
C-C chemokine receptor type 4	0	2	0	2
Spike glycoprotein	10	0	0	10
Gamma-aminobutyric acid receptor subunit alpha-1	4	4	2	10
Gamma-aminobutyric acid receptor subunit beta-3	4	3	2	9
Gamma-aminobutyric acid receptor subunit beta-2	4	3	2	9
Sodium channel protein type 7 subunit alpha	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	4	0	4
Sodium-dependent dopamine transporter	0	6	1	7
Potassium voltage-gated channel subfamily H member 2	0	9	0	9
Voltage-dependent L-type calcium channel subunit alpha-1S	0	4	0	4
Voltage-dependent L-type calcium channel subunit alpha-1C	0	5	0	5
Sodium channel protein type 5 subunit alpha	0	4	0	4
Squalene monooxygenase	0	1	0	1
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase	0	1	0	1
Sodium channel protein type 9 subunit alpha	0	1	0	1
Lysine-specific demethylase 7A	0	1	0	1
GABA theta subunit	4	3	2	9
Carnitine O-palmitoyltransferase 1, muscle isoform	0	1	0	1
Inositol hexakisphosphate kinase 1	5	0	0	5
Sodium channel protein type 2 subunit alpha	0	2	0	2
Ataxin-2	7	0	0	7
Sigma non-opioid intracellular receptor 1	0	9	1	10
Gamma-aminobutyric acid receptor subunit epsilon	4	3	2	9
NAD-dependent protein deacetylase sirtuin-3, mitochondrial	0	0	1	1
Sodium channel protein type 3 subunit alpha	0	2	0	2
Sodium channel protein type 11 subunit alpha	0	1	0	1
Histone lysine demethylase PHF8	0	1	0	1
Sodium channel protein type 8 subunit alpha	0	1	0	1
Sodium channel protein type 10 subunit alpha	0	1	0	1
cytochrome P450 2C9, partial	5	0	0	5
ATP-dependent phosphofructokinase	3	0	0	3
vitamin D3 receptor isoform VDRA	6	0	0	6
Translocator protein	0	1	1	2
Vasopressin V2 receptor	0	2	1	4
Oxytocin receptor	0	1	1	2
Vasopressin V1a receptor	0	0	3	3
Vasopressin V1a receptor	0	2	2	4
Vasopressin V1b receptor	0	1	1	2
Vasopressin V2 receptor	0	0	1	1
Vasopressin V1b receptor	0	1	1	3
Translocator protein	0	1	0	2
Oxytocin receptor	0	1	1	2
Vasopressin V2 receptor	0	1	1	2
Chain A, Hyaluronidase, phage associated	0	1	0	1
GLI family zinc finger 3	14	0	0	14
thioredoxin glutathione reductase	3	0	0	3
cytochrome P450 family 3 subfamily A polypeptide 4	11	0	0	11
vitamin D (1,25- dihydroxyvitamin D3) receptor	7	0	0	7
nuclear factor erythroid 2-related factor 2 isoform 2	4	0	0	5
lethal(3)malignant brain tumor-like protein 1 isoform I	1	0	0	1
Polyphenol oxidase 2	0	1	0	1
Pancreatic alpha-amylase	0	2	0	2
Albumin	0	2	0	2
Urease	0	1	0	1
Prolyl 4-hydroxylase subunit alpha-1	0	0	0	1
Tyrosinase	0	1	0	1
Hyaluronate lyase	0	1	0	1
Prolyl hydroxylase EGLN2	0	0	0	1
Egl nine homolog 1	0	0	0	1
Prolyl hydroxylase EGLN3	0	0	0	1
Hypoxia-inducible factor 1-alpha inhibitor	0	0	0	1
Solute carrier family 23 member 1	0	1	0	1
Chain A, Phospholipase A2 isoform 3	0	0	1	1
Chain A, HADH2 protein	4	0	0	4
Chain B, HADH2 protein	4	0	0	4
Chain A, 2-oxoglutarate Oxygenase	4	0	0	4
GTP-binding protein (rab7)	0	0	1	1
ras protein, partial	0	0	1	1
interleukin 8	4	0	0	4
thioredoxin reductase	7	0	0	7
GLS protein	5	0	0	5
hypothetical protein, conserved	2	0	0	2
glucocerebrosidase	2	0	0	2
Rac1 protein	0	0	1	1
cell division cycle 42 (GTP binding protein, 25kDa), partial	0	0	1	1
Bloom syndrome protein isoform 1	4	0	0	4
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	5	0	0	5
DNA polymerase iota isoform a (long)	4	0	0	4
DNA polymerase kappa isoform 1	4	0	0	4
Prostaglandin-H2 D-isomerase	0	2	0	2
Solute carrier family 22 member 6	0	4	0	4
Prostaglandin G/H synthase 1	0	3	0	4
Prostaglandin G/H synthase 2	0	3	0	4
Carbonic anhydrase 1	0	5	0	7
Carbonic anhydrase 2	0	5	0	7
Fatty acid-binding protein, liver	0	2	0	2
Myeloperoxidase	0	1	0	1
Prostaglandin G/H synthase 1	0	5	0	6
Seed linoleate 13S-lipoxygenase-1	0	1	0	1
Glutathione hydrolase 1 proenzyme	0	1	0	1
Prostaglandin G/H synthase 1	0	5	0	5
Substance-P receptor	0	3	0	3
Prostaglandin G/H synthase 2	0	5	1	6
Urotensin-2 receptor	0	1	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	2	0	2
Nuclear receptor ROR-gamma	5	1	1	7
Ras-related protein Rab-2A	0	0	1	1
Prostaglandin G/H synthase 2	0	5	0	5
Rho-associated protein kinase 2	0	2	0	2
Nicotinate phosphoribosyltransferase	0	2	0	2
Solute carrier family 22 member 20	0	3	0	3
Solute carrier family 22 member 6	0	3	0	3
Sigma non-opioid intracellular receptor 1	0	2	2	4
Potassium channel subfamily K member 3	0	2	0	2
Potassium channel subfamily K member 3	0	1	0	1
Potassium channel subfamily K member 2	0	1	1	2
Potassium channel subfamily K member 9	0	1	0	1
Carbonic anhydrase 4	0	2	0	4
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 15	0	1	0	1
Phenylethanolamine N-methyltransferase	0	1	0	1
Amine oxidase [flavin-containing] B	0	1	0	1
Amine oxidase [flavin-containing] A	0	2	0	2
Sodium-dependent dopamine transporter	0	1	1	2
Amine oxidase [flavin-containing] B	0	2	0	2
Amine oxidase [flavin-containing] B	0	1	0	1
Trace amine-associated receptor 1	0	0	1	1
Trace amine-associated receptor 1	0	0	1	1
Trace amine-associated receptor 1	0	0	1	1
Trace amine-associated receptor 1	0	0	1	1
Chain A, Beta-lactamase	5	0	0	5
Chain A, ATP-DEPENDENT DNA HELICASE Q1	1	0	0	1
Chain A, Cruzipain	3	0	0	3
PAX8	0	0	0	1
STAT3, partial	0	1	0	1
Smad3	4	0	0	4
67.9K protein	5	0	0	5
alpha-galactosidase	2	0	0	2
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	6	0	0	6
activating transcription factor 6	8	0	0	8
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	5	0	0	5
NPC intracellular cholesterol transporter 1 precursor	1	0	0	1
tumor necrosis factor	1	0	0	1
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	4	0	0	4
ras-related protein Rab-9A	2	0	0	2
signal transducer and activator of transcription 1-alpha/beta isoform alpha	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-1	0	2	0	2
Sodium/potassium-transporting ATPase subunit beta-1	0	2	0	2
Sodium/potassium-transporting ATPase subunit alpha-2	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-3	0	1	0	1
Sodium/potassium-transporting ATPase subunit beta-1	0	1	0	1
Cytochrome P450 3A4	0	4	1	5
Replicase polyprotein 1ab	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-3	0	1	0	1
Sodium/potassium-transporting ATPase subunit beta-2	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-2	0	2	0	2
Sodium/potassium-transporting ATPase subunit alpha-1	0	1	0	1
Sodium/potassium-transporting ATPase subunit beta-3	0	1	0	1
Sodium/potassium-transporting ATPase subunit gamma	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-4	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-4	0	1	0	1
Solute carrier organic anion transporter family member 4C1	0	0	0	1
Solute carrier organic anion transporter family member 4C1	0	0	0	1
ATPase family AAA domain-containing protein 5	4	0	0	4
Solute carrier organic anion transporter family member 1A4	0	0	0	1
Solute carrier organic anion transporter family member 1B3	0	3	0	3
Solute carrier organic anion transporter family member 1B1	0	3	0	3
prostaglandin E2 receptor EP2 subtype	1	0	0	1
Solute carrier family 22 member 2	0	3	0	4
Solute carrier family 22 member 1	0	9	0	12
Solute carrier organic anion transporter family member 1A5	0	0	0	1
Prostaglandin E2 receptor EP1 subtype	0	2	1	3
Prostaglandin E2 receptor EP4 subtype	0	2	1	3
Prostaglandin F2-alpha receptor	0	0	1	1
Prostaglandin E2 receptor EP4 subtype	0	1	1	2
Prostaglandin E2 receptor EP3 subtype	0	2	1	3
Prostaglandin E2 receptor EP2 subtype	0	2	1	3
Solute carrier family 22 member 6	0	2	0	3
Solute carrier family 22 member 7	0	0	0	2
Prostaglandin E2 receptor EP2 subtype	0	1	1	2
Solute carrier family 22 member 8	0	2	0	3
Solute carrier family 22 member 7	0	0	0	1
Solute carrier family 22 member 11	0	0	0	1
Solute carrier organic anion transporter family member 1B2	0	0	0	1
Solute carrier family 22 member 7	0	0	0	1
Chain A, Breast cancer type 1 susceptibility protein	1	0	0	1
Chain A, Ferritin light chain	2	0	0	2
acid sphingomyelinase	1	0	0	1
RGS12	1	0	0	1
90-kda heat shock protein beta HSP90 beta, partial	0	1	0	1
Microtubule-associated protein tau	3	0	0	3
DNA polymerase III, partial	1	0	0	1
isocitrate dehydrogenase 1, partial	1	0	0	1
nonstructural protein 1	3	0	0	3
LANA	0	0	0	1
bromodomain adjacent to zinc finger domain 2B	2	0	0	2
thyrotropin-releasing hormone receptor	2	0	0	2
serine-protein kinase ATM isoform a	1	0	0	1
lysosomal alpha-glucosidase preproprotein	1	0	0	1
peripheral myelin protein 22 isoform 1	4	0	0	4
cytochrome P450 2C19 precursor	2	0	0	2
guanine nucleotide-binding protein G(i) subunit alpha-1 isoform 1	1	0	0	1
importin subunit beta-1 isoform 1	3	0	0	3
ubiquitin carboxyl-terminal hydrolase 2 isoform a	1	0	0	1
serine/threonine-protein kinase PLK1	1	0	0	1
eyes absent homolog 2 isoform a	1	0	0	1
heat shock protein HSP 90-alpha isoform 2	0	1	0	1
snurportin-1	3	0	0	3
histone-lysine N-methyltransferase 2A isoform 2 precursor	1	0	0	1
tumor susceptibility gene 101 protein	1	0	0	1
GTP-binding nuclear protein Ran isoform 1	1	0	0	1
muscleblind-like protein 1 isoform 1	2	0	0	2
histone acetyltransferase KAT2A isoform 1	4	0	0	4
caspase-1 isoform alpha precursor	1	0	0	1
DNA dC->dU-editing enzyme APOBEC-3F isoform a	1	0	0	1
kelch-like ECH-associated protein 1	0	0	0	2
neuropeptide S receptor isoform A	3	0	0	3
cGMP-dependent 3',5'-cyclic phosphodiesterase	0	1	0	1
Multidrug resistance-associated protein 5	0	1	0	1
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta	0	1	0	1
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A	0	1	0	1
cGMP-specific 3',5'-cyclic phosphodiesterase	0	2	0	2
3',5'-cyclic-AMP phosphodiesterase	0	2	0	2
Neuronal acetylcholine receptor subunit alpha-4	1	1	0	2
Neuronal acetylcholine receptor subunit beta-2	1	1	0	2
Polyunsaturated fatty acid lipoxygenase ALOX15	0	3	0	3
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha	0	1	0	1
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	1	0	1
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta	0	1	0	1
Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	0	1	0	1
Caspase-7	1	0	0	1
Disintegrin and metalloproteinase domain-containing protein 17	1	0	0	1
Inositol monophosphatase 1	1	0	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4C	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
TAR DNA-binding protein 43	2	0	0	2
cGMP-inhibited 3',5'-cyclic phosphodiesterase B	0	1	0	1
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A	0	1	0	1
Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	0	1	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase A	0	1	0	1
Exopolyphosphatase PRUNE1	0	1	0	1
Multidrug and toxin extrusion protein 2	0	2	0	2
Rap guanine nucleotide exchange factor 4	1	0	0	1
Multidrug and toxin extrusion protein 1	0	7	0	7
Single-stranded DNA cytosine deaminase	1	0	0	1
Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 7B	0	1	0	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	2	0	2
Phosphodiesterase	0	1	0	1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	0	1	0	1
5-hydroxytryptamine receptor 7	0	4	0	4
Solute carrier family 22 member 1	0	5	0	6
Solute carrier family 22 member 2	0	5	0	5
endonuclease IV	2	0	0	2
Angiotensin-converting enzyme	0	2	0	2
Angiotensin-converting enzyme	0	1	0	1
Type-2 angiotensin II receptor	0	1	0	1
Succinyl-diaminopimelate desuccinylase	0	1	0	1
Solute carrier family 15 member 1	0	1	0	1
Solute carrier organic anion transporter family member 1A1	0	2	0	3
Angiotensin-converting enzyme	0	1	0	1
Solute carrier family 15 member 1	0	1	0	1
Angiotensin-converting enzyme 2	0	1	0	1
Luciferase	3	0	0	3
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Delta-type opioid receptor	0	4	1	6
Delta-type opioid receptor	0	4	2	6
Mu-type opioid receptor	0	5	3	8
Kappa-type opioid receptor	0	2	2	4
Histamine H1 receptor	0	1	0	1
Kappa-type opioid receptor	0	4	1	5
Mu-type opioid receptor	0	2	0	3
Mu-type opioid receptor	0	5	1	6
Sigma non-opioid intracellular receptor 1	0	4	0	4
aryl hydrocarbon receptor	4	0	0	4
Carbonic anhydrase 12	0	1	0	3
Bile salt export pump	0	4	0	4
Albumin	0	3	4	7
Carbonic anhydrase 3	0	1	0	2
Glucose-6-phosphate 1-dehydrogenase	0	1	0	1
Cytochrome P450 2C9	0	8	0	8
Carbonic anhydrase 6	0	1	0	3
Serum paraoxonase/arylesterase 1	0	2	0	2
Corticosteroid 11-beta-dehydrogenase isozyme 1	0	1	0	1
Carbonic anhydrase 5A, mitochondrial	0	1	0	3
Carbonic anhydrase 7	0	1	0	3
Corticosteroid 11-beta-dehydrogenase isozyme 1	0	1	0	1
Cytochrome P450 2J2	0	5	0	5
6-phosphogluconate dehydrogenase, decarboxylating	0	1	0	1
Holo-[acyl-carrier-protein] synthase	0	1	0	1
Sodium/bile acid cotransporter	0	2	0	2
Carbonic anhydrase 9	0	1	0	3
Carbonic anhydrase 13	0	1	0	3
G-protein coupled receptor 35	0	1	1	2
CDGSH iron-sulfur domain-containing protein 1	0	2	0	2
Carbonic anhydrase 14	0	1	0	3
Carbonic anhydrase 5B, mitochondrial	0	1	0	3
M-phase phosphoprotein 8	2	0	0	2
Uracil nucleotide/cysteinyl leukotriene receptor	0	2	0	2
transcriptional regulator ERG isoform 3	1	0	0	1
Acid-sensing ion channel 3	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Albumin	0	0	2	2
Cholinesterase	0	2	0	2
Fatty acid-binding protein, intestinal	0	1	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	2	0	4
UDP-glucuronosyltransferase 2B7	0	2	0	3
Acetylcholinesterase	0	3	0	3
Prostaglandin G/H synthase 1	0	2	0	2
Caspase-1	0	1	0	2
Prostaglandin G/H synthase 2	0	2	0	3
UDP-glucuronosyltransferase 1A3	0	0	0	1
Aldo-keto reductase family 1 member C3	0	3	0	3
Caspase-3	0	1	0	1
Caspase-4	0	1	0	1
Caspase-5	0	1	0	1
Caspase-9	0	1	0	1
Acid-sensing ion channel 1	0	1	0	1
Fatty-acid amide hydrolase 1	0	2	0	2
Prostaglandin G/H synthase 2	0	2	0	3
Prostaglandin G/H synthase 1	0	2	0	3
Dehydrogenase/reductase SDR family member 9	0	1	0	1
Liver carboxylesterase 1	0	0	0	1
Chain A, membrane-associated prostaglandin E synthase-2	0	1	0	1
Chain A, Putative fructose-1,6-bisphosphate aldolase	2	0	0	2
Parkin	1	0	0	1
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	1	0	0	1
Prostaglandin E synthase	0	1	0	1
Solute carrier organic anion transporter family member 2B1	0	2	0	2
Cytochrome c oxidase subunit 2	0	1	0	1
Phospholipase A2, major isoenzyme	0	1	0	1
Procathepsin L	0	1	0	1
Interleukin-8	0	1	0	1
Androgen receptor	0	2	2	4
Aldo-keto reductase family 1 member B1	0	1	0	1
Aldo-keto reductase family 1 member B1	0	1	0	1
Aldo-keto reductase family 1 member C4	0	1	0	1
Sodium- and chloride-dependent GABA transporter 1	0	2	0	2
Indoleamine 2,3-dioxygenase 1	0	1	0	1
Nitric oxide synthase, inducible	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	2	0	2
Sodium- and chloride-dependent GABA transporter 3	0	2	0	2
Multidrug resistance-associated protein 1	0	1	0	1
Bifunctional epoxide hydrolase 2	0	1	0	1
Peroxisome proliferator-activated receptor gamma	0	0	1	1
Sodium- and chloride-dependent betaine transporter	0	2	0	2
C-X-C chemokine receptor type 3	0	1	0	1
Aldo-keto reductase family 1 member C2	0	1	0	1
Guanine nucleotide-binding protein G	1	0	0	1
Prostaglandin D2 receptor	0	2	0	2
Solute carrier organic anion transporter family member 1A3	0	1	0	1
Lactoylglutathione lyase	0	1	0	1
Aldo-keto reductase family 1 member C1	0	1	0	1
Sigma intracellular receptor 2	0	1	0	1
Dehydrogenase/reductase SDR family member 9	0	1	0	1
P2Y purinoceptor 12	0	1	0	1
Cytosolic phospholipase A2 gamma	0	1	0	1
Prostaglandin D2 receptor 2	0	1	1	2
glp-1 receptor, partial	3	0	0	3
Beta-1 adrenergic receptor	0	1	2	5
beta-2 adrenergic receptor	1	0	0	1
hexokinase-4 isoform 1	1	0	0	1
glucokinase regulatory protein	1	0	0	1
Beta-2 adrenergic receptor	0	6	3	10
Beta-2 adrenergic receptor	0	4	1	6
Beta-1 adrenergic receptor	0	4	2	8
Beta-2 adrenergic receptor	0	0	1	1
Alpha-2B adrenergic receptor	0	2	1	3
Alpha-2C adrenergic receptor	0	2	1	3
Alpha-2A adrenergic receptor	0	2	1	3
Alpha-1D adrenergic receptor	0	3	1	4
Beta-adrenergic receptor kinase 1	0	0	1	1
Alpha-1D adrenergic receptor	0	0	2	3
Beta-3 adrenergic receptor	0	0	1	1
Beta-3 adrenergic receptor	0	3	1	4
Beta-1 adrenergic receptor	0	2	1	3
Alpha-1A adrenergic receptor	0	1	3	5
Alpha-1B adrenergic receptor	0	0	2	3
Glutamate receptor ionotropic, NMDA 1	0	0	1	1
Beta-2 adrenergic receptor	0	2	0	2
Taste receptor type 2 member 38	0	0	1	1
Taste receptor type 2 member 39	0	0	1	1
Taste receptor type 2 member 40	0	0	1	1
Taste receptor type 2 member 41	0	0	1	1
Taste receptor type 2 member 43	0	0	1	1
Taste receptor type 2 member 31	0	0	1	1
Taste receptor type 2 member 45	0	0	1	1
Taste receptor type 2 member 46	0	0	1	1
Taste receptor type 2 member 30	0	0	1	1
Taste receptor type 2 member 19	0	0	1	1
Taste receptor type 2 member 20	0	0	1	1
Taste receptor type 2 member 50	0	0	1	1
Taste receptor type 2 member 60	0	0	1	1
Glutamate receptor ionotropic, NMDA 2A	0	0	1	1
Glutamate receptor ionotropic, NMDA 2B	0	0	1	1
Glutamate receptor ionotropic, NMDA 2C	0	0	1	1
Beta-2 adrenergic receptor	0	1	1	2
Glutamate receptor ionotropic, NMDA 2D	0	0	1	1
Taste receptor type 2 member 42	0	0	1	1
Beta-2 adrenergic receptor	0	2	3	6
Glutamate receptor ionotropic, NMDA 3B	0	0	1	1
Taste receptor type 2 member 16	0	0	1	1
Taste receptor type 2 member 14	0	0	1	1
Taste receptor type 2 member 13	0	0	1	1
Taste receptor type 2 member 10	0	0	1	1
Taste receptor type 2 member 9	0	0	1	1
Taste receptor type 2 member 8	0	0	1	1
Taste receptor type 2 member 7	0	0	1	1
Taste receptor type 2 member 5	0	0	1	1
Taste receptor type 2 member 4	0	0	1	1
Taste receptor type 2 member 3	0	0	1	1
Taste receptor type 2 member 1	0	0	1	1
Glutamate receptor ionotropic, NMDA 3A	0	0	1	1
2,3-bisphosphoglycerate-independent phosphoglycerate mutase	1	0	0	1
UDP-glucuronosyltransferase 1-6	0	2	0	2
UDP-glucuronosyltransferase 1A1	0	2	0	2
UDP-glucuronosyltransferase 1A4	0	2	0	2
UDP-glucuronosyltransferase 2B10	0	2	0	2
Chain B, Exotoxin A	0	0	1	1
Chain B, Exotoxin A	0	0	1	1
Chain B, Exotoxin A	0	0	1	1
Muscarinic acetylcholine receptor M1	0	1	0	1
Muscarinic acetylcholine receptor M3	0	1	0	1
Muscarinic acetylcholine receptor M4	0	1	0	1
Muscarinic acetylcholine receptor M5	0	1	0	1
Cytochrome P450 2D6	0	5	0	5
Muscarinic acetylcholine receptor M2	0	1	0	1
Histidine decarboxylase	0	0	1	1
D(3) dopamine receptor	0	2	0	2
Kappa-type opioid receptor	0	1	0	2
UDP-glucuronosyltransferase 1A8	0	0	0	2
Atrial natriuretic peptide receptor 1	0	1	0	1
pregnane X receptor	2	0	0	2
Glucocorticoid receptor	0	4	2	6
Glycine receptor subunit alpha-1	0	4	0	4
Glycine receptor subunit beta	0	4	0	4
Glycine receptor subunit alpha-2	0	4	0	4
Glycine receptor subunit alpha-3	0	4	0	4
Solute carrier family 22 member 1	0	1	0	1
Sterol O-acyltransferase 1	0	1	0	1
Solute carrier family 22 member 2	0	1	0	1
Solute carrier family 22 member 3	0	1	0	1
Acetylcholinesterase	0	1	0	1
DNA (cytosine-5)-methyltransferase 1	0	1	0	1
Sterol O-acyltransferase 1	0	1	0	1
Solute carrier family 22 member 4	0	1	0	1
DNA (cytosine-5)-methyltransferase 3-like	0	1	0	1
DNA (cytosine-5)-methyltransferase 3A	0	1	0	1
ATP-binding cassette sub-family C member 9	0	1	0	1
Cytochrome P450 1A2	0	2	0	2
ATP-sensitive inward rectifier potassium channel 11	0	1	0	1
Lanosterol 14-alpha demethylase	0	1	0	1
Nuclear receptor subfamily 2 group E member 1	0	0	3	3
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Fatty-acid amide hydrolase 1	0	1	0	1
UDP-glucuronosyltransferase 1A9	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	0	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	1	2
Gamma-aminobutyric acid receptor subunit beta-1	0	0	1	1
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-4	0	0	0	1
Gamma-aminobutyric acid receptor subunit gamma-2	0	0	0	1
Gamma-aminobutyric acid receptor subunit beta-3	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-5	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	0	1	1
Gamma-aminobutyric acid receptor subunit beta-2	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	0	1	1
5-hydroxytryptamine receptor 1A	0	1	0	1
Alpha-2C adrenergic receptor	0	1	2	4
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
5-hydroxytryptamine receptor 1B	0	2	1	3
Neuromedin-K receptor	0	0	1	1
Type-1 angiotensin II receptor	0	1	1	2
Cholecystokinin receptor type A	0	1	1	2
Cytochrome P450 2C19	0	2	0	2
5-hydroxytryptamine receptor 7	0	1	1	2
Histidine-rich protein PFHRP-II	0	1	0	1
Cytochrome P450 2D1	0	1	0	1
Cytochrome P450 2D26	0	1	0	1
Cytochrome P450 2D3	0	1	0	1
Potassium voltage-gated channel subfamily A member 5	0	1	0	1
Cholinesterase	0	1	0	1
Potassium voltage-gated channel subfamily D member 2	0	1	0	1
Cytochrome P450 2D4	0	1	0	1
Multidrug resistance protein 1a	0	0	0	1
nuclear receptor subfamily 1, group I, member 2	1	0	0	1
Chain A, Mineralocorticoid receptor	0	1	0	1
Chain A, Mineralocorticoid receptor	0	1	0	1
Vpr	1	0	0	1
Estrogen receptor	0	2	1	3
Progesterone receptor	0	2	1	3
Mineralocorticoid receptor	0	2	0	3
Estrogen receptor beta	0	1	1	2
Urease subunit alpha	0	1	0	1
Urease subunit beta	0	1	0	1
Olfactory receptor 51E2	0	0	1	1
Proprotein convertase subtilisin/kexin type 7	0	1	0	1
Vitamin K epoxide reductase complex subunit 1-like protein 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1	0	1	0	1
Protease	0	1	0	1
Vitamin K epoxide reductase complex subunit 1-like protein 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1	0	2	0	2
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

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