Page last updated: 2024-09-28

Ebstein Anomaly

A congenital heart defect characterized by downward or apical displacement of the TRICUSPID VALVE, usually with the septal and posterior leaflets being attached to the wall of the RIGHT VENTRICLE. It is characterized by a huge RIGHT ATRIUM and a small and less effective right ventricle.

Synonyms(4)

Synonym
Ebstein Anomaly
Familial Ebstein's Anomaly
Ebstein's Anomaly
Ebstein's Malformation

Research Excerpts

Overview

ExcerptReference
"Ebstein's anomaly is an uncommon congenital cardiac defect which is associated with cyanosis and arrhythmias."( Groves, ER; Groves, JB, 1995)
"Ebstein's anomaly is a rare congenital cardiac anomaly showing significant clinical manifestations with a high mortality rate in the neonatal period."( Hayasaka, K; Komatsu, H; Nakasato, M; Sato, S; Suzuki, H, 1997)
"Ebstein anomaly is a rare tricuspid valve anomaly."( Chang, CC; Hsieh, YY; Lee, CC; Tsai, CH; Tsai, HD; Yeh, LS, 1998)
"Ebstein's anomaly is defined as the significant apical displacement of the part of the tricuspid valve causing significant tricuspid regurgitation and reduction of the functional right ventricle."( Chmara, E; Cieśliński, A; Gwizdała, A; Katarzyński, S; Oko-Sarnowska, Z; Siniawski, A; Straburzyńska-Migaj, E; Szyszka, A; Trojnarska, O, 2006)
"Ebstein's anomaly is a rare congenital cardiac defect associated with both displacement and incompetence of the tricuspid valve."( Macfarlane, AJ; Moise, S; Smith, D, 2007)
"Ebstein's anomaly is a rare congenital heart defect."( de Zorzi, A; Del Pasqua, A; Rinelli, G; Sanders, SP, 2008)
"Ebstein's anomaly is a rare congenital malformation of the tricuspid valve, often associated with Wolff-Parkinson-White (WPW) syndrome."( Kawahito, S; Kawano, H; Kitahata, H; Nakamura, T; Okada, T; Oshita, S, 2009)
"Ebstein's anomaly is a rare congenital cardiac abnormality, associated with cyanosis and arrhythmia."( Aggarwal, N; Chopra, S; Keepanasseril, A; Rohilla, M; Suri, V; Vijayvergiya, R, 2010)
"Ebstein anomaly is a rare congenital heart disease that has been described in domestic dogs, a meerkat, a pygmy goat, and a lion."( Habara, T; Hirata, S; Komai, H; Nishimura, S; Shimada, T; Shimamura, S; Shiota, Y; Takagi, N; Tani, H, 2017)
"Ebstein's anomaly is a rare congenital heart disease characterized by apical displacement of the septal and posterior tricuspid valve leaflets."( Amiya, E; Fujiu, K; Hatano, M; Kojima, T; Komuro, I; Numata, G; Watanabe, M, 2017)
"Ebstein anomaly is a congenital heart defect with a low prevalence and high mortality in the early stages of life."( Manotas, H; Olivella, A; Payán-Gómez, C; Piñeros, JG, 2020)

Context

ExcerptReference
"Some fetuses with Ebstein's anomaly have concurrent severe cardiac function impairment, which results in hydrops fetalis."( Chang, CC; Hsieh, YY; Lee, CC; Tsai, CH; Tsai, HD; Yeh, LS, 1998)

Treatment

ExcerptReference
"Prenatally diagnosed Ebstein's anomaly with tricuspid valve dysplasia (EA/TVD) is a rare and high-risk congenital heart malformation with limited effective treatments."( Kraus, E; Lannaman, K; Powel, JE; Reddy, C, 2022)

Research

Studies (107)

TimeframeStudies, This Condition (%)All Conditions %
pre-199045 (42.06)23.3326
1990's11 (10.28)12.5806
2000's21 (19.63)18.1394
2010's20 (18.69)28.8240
2020's10 (9.35)9.53
DrugIndicatedRelationship StrengthStudiesTrials
hydrogen0low10
nitrous oxide0low10
urea0low10
hydroxyindoleacetic acid0low10
amiodarone0low20
aspirin0low10
bupivacaine0low10
disopyramide0low10
fentanyl0low10
furosemide0low30
gentamicin0low10
glutaral0low10
ibuprofen0low10
indomethacin0low50
isoproterenol0low10
midazolam0low10
phenobarbital0low10
procainamide0low20
procaine0low10
propafenone0low10
propofol0low10
propranolol0low30
sevoflurane0low10
dextroamphetamine0low10
spironolactone0low10
prednisone0low20
isosorbide dinitrate0low10
lithium carbonate0low40
carbonates0low10
platinum0low10
silver0low10
tantalum0low10
technetium0low50
titanium0low10
gadolinium0low20
gold0low10
remifentanil0low10
adenosine0medium31
cephalosporin c0low10
fibrinogen0low20
landiolol0low10
mt 07030low10
glycogen0low10
quinidine0low20
imidazolidines0low10
arginine vasopressin0low10
digoxin0low100
nadp0low10
lithium0low150
nitrogen dioxide0low10
alprostadil0low40
enalapril0low10
imidapril0low10
gadolinium dtpa0low10
enerbol0low20
nad0low10
cardiovascular agents0low20
piperidines0low10
natriuretic peptide, brain0medium41
ascorbic acid0low10
sildenafil citrate0low10

Protein Targets (752)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
5-hydroxytryptamine receptor 2C0123
5-hydroxytryptamine receptor 2A0123
5-hydroxytryptamine receptor 1A0539
5-hydroxytryptamine receptor 1B0527
5-hydroxytryptamine receptor 1D0123
5-hydroxytryptamine receptor 1F0123
5-hydroxytryptamine receptor 2B0123
5-hydroxytryptamine receptor 60022
Sodium-dependent serotonin transporter0628
Sodium-dependent serotonin transporter0213
5-hydroxytryptamine receptor 7 0022
5-hydroxytryptamine receptor 5A0022
5-hydroxytryptamine receptor 5B0022
5-hydroxytryptamine receptor 3A0022
5-hydroxytryptamine receptor 4 0022
5-hydroxytryptamine receptor 3B0022
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE7007
Chain A, Membrane lipoprotein tmpC0011
Chain A, Membrane lipoprotein tmpC0011
Chain A, Membrane lipoprotein tmpC0011
Chain A, Structure of PAE2307 in complex with adenosine0011
Chain B, Structure of PAE2307 in complex with adenosine0011
Chain A, ADENOSINE RECEPTOR A2A0101
Chain A, ADENOSINE RECEPTOR A2A0101
Chain A, tRNA (guanine-N(1)-)-methyltransferase0011
Chain A, Uncharacterized protein MJ08830011
AR protein210021
signal transducer and activator of transcription 6, interleukin-4 induced1001
regulator of G-protein signaling 48008
glucocorticoid receptor [Homo sapiens]160016
retinoid X nuclear receptor alpha100010
estrogen nuclear receptor alpha240024
NPYLR7B0033
arylsulfatase A4004
IDH18008
Histone H2A.x8008
glycogen synthase kinase-3 beta isoform 10011
mitogen-activated protein kinase 14004
flap endonuclease 13003
nuclear receptor ROR-gamma isoform 16006
peripheral myelin protein 22100010
survival motor neuron protein isoform d4004
high affinity choline transporter 1 isoform a0101
Sodium/nucleoside cotransporter 10202
Calcium dependent protein kinase0101
Mitogen-activated protein kinase kinase kinase 70011
Sodium/nucleoside cotransporter 20202
Voltage-dependent calcium channel gamma-2 subunit5005
Rap guanine nucleotide exchange factor 33003
Purine nucleoside phosphorylase0101
Epidermal growth factor receptor0404
Phosphoglycerate kinase 1 0101
Adenosine deaminase0001
Avidin0011
Adenosine deaminase0001
Glyceraldehyde-3-phosphate dehydrogenase0202
Receptor tyrosine-protein kinase erbB-20202
Insulin receptor0001
Phosphoglycerate kinase 20101
Heat shock protein HSP 90-alpha0112
Platelet-derived growth factor receptor beta0001
Adenosine receptor A30539
Heat shock 70 kDa protein 1A 0101
Heat shock cognate 71 kDa protein0011
Fibroblast growth factor receptor 10001
Inosine-5'-monophosphate dehydrogenase 20101
Endoplasmin0112
Glutamate receptor 25005
Inosine-5'-monophosphate dehydrogenase 1 0101
Fibroblast growth factor receptor 20001
Fibroblast growth factor receptor 40001
Fibroblast growth factor receptor 30001
Streptavidin0011
Adenosylhomocysteinase0001
Adenosine receptor A10415
Adenosine receptor A30101
Adenosine receptor A2a0236
Adenosine receptor A2b0012
Adenosine receptor A2b0112
Adenylate kinase 2, mitochondrial0101
Adenosine receptor A10326
Adenosine receptor A2a0415
Adenylate kinase isoenzyme 1 0101
Phosphatidylinositol 4-kinase alpha0203
Adenosine receptor A10112
Adenosine kinase0001
Adenosine deaminase 0001
Equilibrative nucleoside transporter 20202
Phosphatidylinositol 4-kinase type 2-beta0203
Histone-lysine N-methyltransferase, H3 lysine-79 specific0101
Equilibrative nucleoside transporter 10404
Phosphatidylinositol 4-kinase type 2-alpha0203
Solute carrier family 28 member 30202
Adenosine kinase0102
Phosphatidylinositol 4-kinase beta0203
5-methylthioadenosine/S-adenosylhomocysteine deaminase0001
Adenosine transporter 10001
TDP1 protein140014
peroxisome proliferator activated receptor gamma100010
ATP-binding cassette sub-family C member 3014014
Multidrug resistance-associated protein 4014016
Bile salt export pump022022
Cellular tumor antigen p53130013
Thromboxane-A synthase 0202
Prostaglandin E2 receptor EP3 subtype0303
Prostaglandin E2 receptor EP4 subtype0314
Prostaglandin E2 receptor EP1 subtype0303
Prostacyclin receptor0325
Nuclear receptor subfamily 4 group A member 20011
Solute carrier organic anion transporter family member 2A10103
Nuclear receptor subfamily 4 group A member 20011
Nuclear receptor subfamily 4 group A member 20011
Prostaglandin E2 receptor EP2 subtype0314
Canalicular multispecific organic anion transporter 1014014
Solute carrier organic anion transporter family member 2A10002
Solute carrier organic anion transporter family member 2B10101
Solute carrier organic anion transporter family member 3A10001
Chain A, TYROSYL-DNA PHOSPHODIESTERASE6006
acetylcholinesterase4004
phosphopantetheinyl transferase2002
hypoxia-inducible factor 1 alpha subunit4004
RAR-related orphan receptor gamma120012
SMAD family member 27007
ATAD5 protein, partial3003
Fumarate hydratase4004
USP1 protein, partial7007
NFKB1 protein, partial4004
PPM1D protein3003
SMAD family member 37007
Thrombopoietin2002
caspase 7, apoptosis-related cysteine protease3003
aldehyde dehydrogenase 1 family, member A1100010
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)6006
thyroid stimulating hormone receptor9009
estrogen receptor 2 (ER beta)8008
nuclear receptor subfamily 1, group I, member 3100010
progesterone receptor9009
EWS/FLI fusion protein8008
retinoic acid nuclear receptor alpha variant 1140014
estrogen-related nuclear receptor alpha160016
farnesoid X nuclear receptor9009
pregnane X nuclear receptor120012
G5005
cytochrome P450 2D67007
polyprotein4004
peroxisome proliferator-activated receptor delta7007
caspase-33003
euchromatic histone-lysine N-methyltransferase 2140014
thyroid stimulating hormone receptor6006
v-jun sarcoma virus 17 oncogene homolog (avian)8008
cytochrome P450 2D6 isoform 14004
cellular tumor antigen p53 isoform a2002
cytochrome P450 2C9 precursor4004
D(1A) dopamine receptor5005
chromobox protein homolog 16006
thyroid hormone receptor beta isoform a7007
potassium voltage-gated channel subfamily H member 2 isoform d8008
thyroid hormone receptor beta isoform 2150015
heat shock protein beta-14004
huntingtin isoform 21001
serine/threonine-protein kinase mTOR isoform 14004
nuclear factor erythroid 2-related factor 2 isoform 1150015
peptidyl-prolyl cis-trans isomerase NIMA-interacting 14004
urokinase-type plasminogen activator precursor3003
plasminogen precursor3003
urokinase plasminogen activator surface receptor precursor3003
geminin130013
cytochrome P450 3A4 isoform 14004
muscarinic acetylcholine receptor M16006
lethal factor (plasmid)6006
lamin isoform A-delta10120012
Gamma-aminobutyric acid receptor subunit pi4329
Polyunsaturated fatty acid lipoxygenase ALOX15B2002
Voltage-dependent L-type calcium channel subunit alpha-1C0303
Solute carrier organic anion transporter family member 1A40405
Voltage-dependent L-type calcium channel subunit alpha-1F0404
5-hydroxytryptamine receptor 40808
Lysine-specific demethylase PHF20101
Interferon beta7007
HLA class I histocompatibility antigen, B alpha chain 5005
Thyroid hormone receptor alpha0101
Integrin beta-32103
Tyrosine-protein kinase Fyn0101
ATP-dependent translocase ABCB10404
Aldo-keto reductase family 1 member B10606
Muscarinic acetylcholine receptor M20314
Muscarinic acetylcholine receptor M40202
ATP-dependent translocase ABCB1014218
Integrin alpha-IIb2103
Beta-1 adrenergic receptor08210
Muscarinic acetylcholine receptor M50202
Alpha-2A adrenergic receptor0326
Cytochrome P450 2C80202
Thyroid hormone receptor alpha0101
Thyroid hormone receptor beta0101
Muscarinic acetylcholine receptor M10314
Beta-3 adrenergic receptor0729
D(2) dopamine receptor0516
Androgen receptor0405
Gamma-aminobutyric acid receptor subunit beta-14329
Alpha-1B adrenergic receptor0516
Lethal factor0101
Alpha-2B adrenergic receptor0225
Thyroid hormone receptor beta0101
Gamma-aminobutyric acid receptor subunit delta4329
Gamma-aminobutyric acid receptor subunit gamma-24329
Gamma-aminobutyric acid receptor subunit alpha-54329
Gamma-aminobutyric acid receptor subunit alpha-34329
Muscarinic acetylcholine receptor M30314
ATP-dependent translocase ABCB10404
Substance-K receptor0202
D(1A) dopamine receptor0415
D(4) dopamine receptor0404
Gamma-aminobutyric acid receptor subunit gamma-14329
Gamma-aminobutyric acid receptor subunit alpha-24329
Carnitine O-palmitoyltransferase 2, mitochondrial0101
Sodium-dependent noradrenaline transporter 0819
Histamine H2 receptor0202
Endothelin-1 receptor0314
5-hydroxytryptamine receptor 2A0617
5-hydroxytryptamine receptor 2C0819
Gamma-aminobutyric acid receptor subunit alpha-44329
Gamma-aminobutyric acid receptor subunit gamma-34329
Lysine-specific demethylase 5A0101
Gamma-aminobutyric acid receptor subunit alpha-64329
B2 bradykinin receptor0202
Melanocortin receptor 40202
C-8 sterol isomerase0101
Melanocortin receptor 50202
Mu-type opioid receptor07311
D(3) dopamine receptor0404
Sodium channel protein type 1 subunit alpha0202
Sodium channel protein type 4 subunit alpha0101
Squalene synthase0101
Delta-type opioid receptor07210
Kappa-type opioid receptor07311
5-hydroxytryptamine receptor 2B0819
C-C chemokine receptor type 20202
Melanocortin receptor 30202
Alpha-1A adrenergic receptor0516
Histamine H2 receptor4015
D(1A) dopamine receptor3003
5-hydroxytryptamine receptor 60617
Carnitine O-palmitoyltransferase 1, liver isoform0101
C-C chemokine receptor type 40202
Spike glycoprotein100010
Gamma-aminobutyric acid receptor subunit alpha-144210
Gamma-aminobutyric acid receptor subunit beta-34329
Gamma-aminobutyric acid receptor subunit beta-24329
Sodium channel protein type 7 subunit alpha0101
Voltage-dependent L-type calcium channel subunit alpha-1D 0404
Sodium-dependent dopamine transporter 0617
Potassium voltage-gated channel subfamily H member 20909
Voltage-dependent L-type calcium channel subunit alpha-1S0404
Voltage-dependent L-type calcium channel subunit alpha-1C0505
Sodium channel protein type 5 subunit alpha0404
Squalene monooxygenase0101
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase0101
Sodium channel protein type 9 subunit alpha0101
Lysine-specific demethylase 7A0101
GABA theta subunit4329
Carnitine O-palmitoyltransferase 1, muscle isoform0101
Inositol hexakisphosphate kinase 15005
Sodium channel protein type 2 subunit alpha0202
Ataxin-27007
Sigma non-opioid intracellular receptor 109110
Gamma-aminobutyric acid receptor subunit epsilon4329
NAD-dependent protein deacetylase sirtuin-3, mitochondrial0011
Sodium channel protein type 3 subunit alpha0202
Sodium channel protein type 11 subunit alpha0101
Histone lysine demethylase PHF80101
Sodium channel protein type 8 subunit alpha0101
Sodium channel protein type 10 subunit alpha0101
cytochrome P450 2C9, partial5005
ATP-dependent phosphofructokinase3003
vitamin D3 receptor isoform VDRA6006
Translocator protein0112
Vasopressin V2 receptor0214
Oxytocin receptor0112
Vasopressin V1a receptor0033
Vasopressin V1a receptor0224
Vasopressin V1b receptor0112
Vasopressin V2 receptor0011
Vasopressin V1b receptor0113
Translocator protein0102
Oxytocin receptor0112
Vasopressin V2 receptor 0112
Chain A, Hyaluronidase, phage associated0101
GLI family zinc finger 3140014
thioredoxin glutathione reductase3003
cytochrome P450 family 3 subfamily A polypeptide 4110011
vitamin D (1,25- dihydroxyvitamin D3) receptor7007
nuclear factor erythroid 2-related factor 2 isoform 24005
lethal(3)malignant brain tumor-like protein 1 isoform I1001
Polyphenol oxidase 20101
Pancreatic alpha-amylase0202
Albumin0202
Urease0101
Prolyl 4-hydroxylase subunit alpha-10001
Tyrosinase0101
Hyaluronate lyase0101
Prolyl hydroxylase EGLN20001
Egl nine homolog 10001
Prolyl hydroxylase EGLN30001
Hypoxia-inducible factor 1-alpha inhibitor0001
Solute carrier family 23 member 10101
Chain A, Phospholipase A2 isoform 30011
Chain A, HADH2 protein4004
Chain B, HADH2 protein4004
Chain A, 2-oxoglutarate Oxygenase4004
GTP-binding protein (rab7)0011
ras protein, partial0011
interleukin 84004
thioredoxin reductase7007
GLS protein5005
hypothetical protein, conserved2002
glucocerebrosidase2002
Rac1 protein0011
cell division cycle 42 (GTP binding protein, 25kDa), partial0011
Bloom syndrome protein isoform 14004
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 15005
DNA polymerase iota isoform a (long)4004
DNA polymerase kappa isoform 14004
Prostaglandin-H2 D-isomerase0202
Solute carrier family 22 member 60404
Prostaglandin G/H synthase 1 0304
Prostaglandin G/H synthase 2 0304
Carbonic anhydrase 10507
Carbonic anhydrase 20507
Fatty acid-binding protein, liver0202
Myeloperoxidase0101
Prostaglandin G/H synthase 10506
Seed linoleate 13S-lipoxygenase-10101
Glutathione hydrolase 1 proenzyme0101
Prostaglandin G/H synthase 10505
Substance-P receptor0303
Prostaglandin G/H synthase 20516
Urotensin-2 receptor0101
4-aminobutyrate aminotransferase, mitochondrial0202
Nuclear receptor ROR-gamma5117
Ras-related protein Rab-2A0011
Prostaglandin G/H synthase 20505
Rho-associated protein kinase 20202
Nicotinate phosphoribosyltransferase0202
Solute carrier family 22 member 200303
Solute carrier family 22 member 60303
Sigma non-opioid intracellular receptor 10224
Potassium channel subfamily K member 30202
Potassium channel subfamily K member 30101
Potassium channel subfamily K member 20112
Potassium channel subfamily K member 90101
Carbonic anhydrase 40204
Carbonic anhydrase0101
Carbonic anhydrase 150101
Phenylethanolamine N-methyltransferase0101
Amine oxidase [flavin-containing] B0101
Amine oxidase [flavin-containing] A0202
Sodium-dependent dopamine transporter0112
Amine oxidase [flavin-containing] B0202
Amine oxidase [flavin-containing] B0101
Trace amine-associated receptor 10011
Trace amine-associated receptor 10011
Trace amine-associated receptor 10011
Trace amine-associated receptor 10011
Chain A, Beta-lactamase5005
Chain A, ATP-DEPENDENT DNA HELICASE Q11001
Chain A, Cruzipain3003
PAX80001
STAT3, partial0101
Smad34004
67.9K protein5005
alpha-galactosidase2002
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a6006
activating transcription factor 68008
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a5005
NPC intracellular cholesterol transporter 1 precursor1001
tumor necrosis factor1001
parathyroid hormone/parathyroid hormone-related peptide receptor precursor4004
ras-related protein Rab-9A2002
signal transducer and activator of transcription 1-alpha/beta isoform alpha0101
Sodium/potassium-transporting ATPase subunit alpha-1 0202
Sodium/potassium-transporting ATPase subunit beta-10202
Sodium/potassium-transporting ATPase subunit alpha-20101
Sodium/potassium-transporting ATPase subunit alpha-3 0101
Sodium/potassium-transporting ATPase subunit beta-1 0101
Cytochrome P450 3A40415
Replicase polyprotein 1ab0101
Sodium/potassium-transporting ATPase subunit alpha-30101
Sodium/potassium-transporting ATPase subunit beta-20101
Sodium/potassium-transporting ATPase subunit alpha-20202
Sodium/potassium-transporting ATPase subunit alpha-10101
Sodium/potassium-transporting ATPase subunit beta-30101
Sodium/potassium-transporting ATPase subunit gamma0101
Sodium/potassium-transporting ATPase subunit alpha-40101
Sodium/potassium-transporting ATPase subunit alpha-40101
Solute carrier organic anion transporter family member 4C10001
Solute carrier organic anion transporter family member 4C10001
ATPase family AAA domain-containing protein 54004
Solute carrier organic anion transporter family member 1A40001
Solute carrier organic anion transporter family member 1B30303
Solute carrier organic anion transporter family member 1B10303
prostaglandin E2 receptor EP2 subtype1001
Solute carrier family 22 member 20304
Solute carrier family 22 member 1 09012
Solute carrier organic anion transporter family member 1A50001
Prostaglandin E2 receptor EP1 subtype0213
Prostaglandin E2 receptor EP4 subtype0213
Prostaglandin F2-alpha receptor0011
Prostaglandin E2 receptor EP4 subtype0112
Prostaglandin E2 receptor EP3 subtype0213
Prostaglandin E2 receptor EP2 subtype0213
Solute carrier family 22 member 60203
Solute carrier family 22 member 70002
Prostaglandin E2 receptor EP2 subtype0112
Solute carrier family 22 member 80203
Solute carrier family 22 member 70001
Solute carrier family 22 member 110001
Solute carrier organic anion transporter family member 1B20001
Solute carrier family 22 member 70001
Chain A, Breast cancer type 1 susceptibility protein1001
Chain A, Ferritin light chain2002
acid sphingomyelinase1001
RGS121001
90-kda heat shock protein beta HSP90 beta, partial0101
Microtubule-associated protein tau3003
DNA polymerase III, partial1001
isocitrate dehydrogenase 1, partial1001
nonstructural protein 13003
LANA0001
bromodomain adjacent to zinc finger domain 2B2002
thyrotropin-releasing hormone receptor2002
serine-protein kinase ATM isoform a1001
lysosomal alpha-glucosidase preproprotein1001
peripheral myelin protein 22 isoform 14004
cytochrome P450 2C19 precursor2002
guanine nucleotide-binding protein G(i) subunit alpha-1 isoform 11001
importin subunit beta-1 isoform 13003
ubiquitin carboxyl-terminal hydrolase 2 isoform a1001
serine/threonine-protein kinase PLK11001
eyes absent homolog 2 isoform a1001
heat shock protein HSP 90-alpha isoform 20101
snurportin-13003
histone-lysine N-methyltransferase 2A isoform 2 precursor1001
tumor susceptibility gene 101 protein1001
GTP-binding nuclear protein Ran isoform 11001
muscleblind-like protein 1 isoform 12002
histone acetyltransferase KAT2A isoform 14004
caspase-1 isoform alpha precursor1001
DNA dC->dU-editing enzyme APOBEC-3F isoform a1001
kelch-like ECH-associated protein 10002
neuropeptide S receptor isoform A3003
cGMP-dependent 3',5'-cyclic phosphodiesterase0101
Multidrug resistance-associated protein 50101
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta0101
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A0101
cGMP-specific 3',5'-cyclic phosphodiesterase0202
3',5'-cyclic-AMP phosphodiesterase 0202
Neuronal acetylcholine receptor subunit alpha-41102
Neuronal acetylcholine receptor subunit beta-21102
Polyunsaturated fatty acid lipoxygenase ALOX150303
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha0101
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma0101
cAMP-specific 3',5'-cyclic phosphodiesterase 4A0101
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta0101
Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'0101
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A0101
Caspase-71001
Disintegrin and metalloproteinase domain-containing protein 171001
Inositol monophosphatase 11001
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B0101
cAMP-specific 3',5'-cyclic phosphodiesterase 4B0101
cAMP-specific 3',5'-cyclic phosphodiesterase 4C0101
cAMP-specific 3',5'-cyclic phosphodiesterase 4D0101
TAR DNA-binding protein 432002
cGMP-inhibited 3',5'-cyclic phosphodiesterase B0101
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A0101
Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma0101
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C0101
cGMP-inhibited 3',5'-cyclic phosphodiesterase A0101
Exopolyphosphatase PRUNE10101
Multidrug and toxin extrusion protein 20202
Rap guanine nucleotide exchange factor 41001
Multidrug and toxin extrusion protein 10707
Single-stranded DNA cytosine deaminase1001
Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A0101
cAMP-specific 3',5'-cyclic phosphodiesterase 7B0101
Broad substrate specificity ATP-binding cassette transporter ABCG20202
Phosphodiesterase 0101
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A0101
5-hydroxytryptamine receptor 70404
Solute carrier family 22 member 10506
Solute carrier family 22 member 20505
endonuclease IV2002
Angiotensin-converting enzyme 0202
Angiotensin-converting enzyme0101
Type-2 angiotensin II receptor0101
Succinyl-diaminopimelate desuccinylase0101
Solute carrier family 15 member 10101
Solute carrier organic anion transporter family member 1A10203
Angiotensin-converting enzyme0101
Solute carrier family 15 member 10101
Angiotensin-converting enzyme 2 0101
Luciferase3003
Nuclear receptor subfamily 1 group I member 20011
Delta-type opioid receptor0416
Delta-type opioid receptor0426
Mu-type opioid receptor0538
Kappa-type opioid receptor0224
Histamine H1 receptor0101
Kappa-type opioid receptor0415
Mu-type opioid receptor0203
Mu-type opioid receptor0516
Sigma non-opioid intracellular receptor 10404
aryl hydrocarbon receptor4004
Carbonic anhydrase 120103
Bile salt export pump0404
Albumin0347
Carbonic anhydrase 30102
Glucose-6-phosphate 1-dehydrogenase0101
Cytochrome P450 2C9 0808
Carbonic anhydrase 60103
Serum paraoxonase/arylesterase 10202
Corticosteroid 11-beta-dehydrogenase isozyme 10101
Carbonic anhydrase 5A, mitochondrial0103
Carbonic anhydrase 70103
Corticosteroid 11-beta-dehydrogenase isozyme 10101
Cytochrome P450 2J20505
6-phosphogluconate dehydrogenase, decarboxylating0101
Holo-[acyl-carrier-protein] synthase0101
Sodium/bile acid cotransporter0202
Carbonic anhydrase 90103
Carbonic anhydrase 130103
G-protein coupled receptor 350112
CDGSH iron-sulfur domain-containing protein 10202
Carbonic anhydrase 140103
Carbonic anhydrase 5B, mitochondrial0103
M-phase phosphoprotein 82002
Uracil nucleotide/cysteinyl leukotriene receptor0202
transcriptional regulator ERG isoform 31001
Acid-sensing ion channel 30101
Dihydrofolate reductase0101
Albumin0022
Cholinesterase0202
Fatty acid-binding protein, intestinal0101
Polyunsaturated fatty acid 5-lipoxygenase0204
UDP-glucuronosyltransferase 2B70203
Acetylcholinesterase0303
Prostaglandin G/H synthase 10202
Caspase-10102
Prostaglandin G/H synthase 2 0203
UDP-glucuronosyltransferase 1A30001
Aldo-keto reductase family 1 member C30303
Caspase-30101
Caspase-40101
Caspase-50101
Caspase-90101
Acid-sensing ion channel 10101
Fatty-acid amide hydrolase 10202
Prostaglandin G/H synthase 20203
Prostaglandin G/H synthase 1 0203
Dehydrogenase/reductase SDR family member 90101
Liver carboxylesterase 10001
Chain A, membrane-associated prostaglandin E synthase-20101
Chain A, Putative fructose-1,6-bisphosphate aldolase2002
Parkin1001
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)1001
Prostaglandin E synthase0101
Solute carrier organic anion transporter family member 2B1 0202
Cytochrome c oxidase subunit 20101
Phospholipase A2, major isoenzyme0101
Procathepsin L0101
Interleukin-80101
Androgen receptor0224
Aldo-keto reductase family 1 member B10101
Aldo-keto reductase family 1 member B10101
Aldo-keto reductase family 1 member C40101
Sodium- and chloride-dependent GABA transporter 10202
Indoleamine 2,3-dioxygenase 10101
Nitric oxide synthase, inducible0101
Sodium- and chloride-dependent GABA transporter 20202
Sodium- and chloride-dependent GABA transporter 30202
Multidrug resistance-associated protein 1 0101
Bifunctional epoxide hydrolase 20101
Peroxisome proliferator-activated receptor gamma0011
Sodium- and chloride-dependent betaine transporter0202
C-X-C chemokine receptor type 30101
Aldo-keto reductase family 1 member C2 0101
Guanine nucleotide-binding protein G1001
Prostaglandin D2 receptor 0202
Solute carrier organic anion transporter family member 1A30101
Lactoylglutathione lyase0101
Aldo-keto reductase family 1 member C10101
Sigma intracellular receptor 20101
Dehydrogenase/reductase SDR family member 90101
P2Y purinoceptor 120101
Cytosolic phospholipase A2 gamma0101
Prostaglandin D2 receptor 20112
glp-1 receptor, partial3003
Beta-1 adrenergic receptor 0125
beta-2 adrenergic receptor1001
hexokinase-4 isoform 11001
glucokinase regulatory protein1001
Beta-2 adrenergic receptor06310
Beta-2 adrenergic receptor0416
Beta-1 adrenergic receptor0428
Beta-2 adrenergic receptor0011
Alpha-2B adrenergic receptor0213
Alpha-2C adrenergic receptor0213
Alpha-2A adrenergic receptor0213
Alpha-1D adrenergic receptor0314
Beta-adrenergic receptor kinase 10011
Alpha-1D adrenergic receptor0023
Beta-3 adrenergic receptor0011
Beta-3 adrenergic receptor0314
Beta-1 adrenergic receptor0213
Alpha-1A adrenergic receptor0135
Alpha-1B adrenergic receptor0023
Glutamate receptor ionotropic, NMDA 1 0011
Beta-2 adrenergic receptor0202
Taste receptor type 2 member 380011
Taste receptor type 2 member 390011
Taste receptor type 2 member 400011
Taste receptor type 2 member 410011
Taste receptor type 2 member 430011
Taste receptor type 2 member 310011
Taste receptor type 2 member 450011
Taste receptor type 2 member 460011
Taste receptor type 2 member 300011
Taste receptor type 2 member 190011
Taste receptor type 2 member 200011
Taste receptor type 2 member 500011
Taste receptor type 2 member 600011
Glutamate receptor ionotropic, NMDA 2A 0011
Glutamate receptor ionotropic, NMDA 2B0011
Glutamate receptor ionotropic, NMDA 2C0011
Beta-2 adrenergic receptor 0112
Glutamate receptor ionotropic, NMDA 2D0011
Taste receptor type 2 member 420011
Beta-2 adrenergic receptor0236
Glutamate receptor ionotropic, NMDA 3B0011
Taste receptor type 2 member 160011
Taste receptor type 2 member 140011
Taste receptor type 2 member 130011
Taste receptor type 2 member 100011
Taste receptor type 2 member 90011
Taste receptor type 2 member 80011
Taste receptor type 2 member 70011
Taste receptor type 2 member 50011
Taste receptor type 2 member 40011
Taste receptor type 2 member 30011
Taste receptor type 2 member 10011
Glutamate receptor ionotropic, NMDA 3A0011
2,3-bisphosphoglycerate-independent phosphoglycerate mutase1001
UDP-glucuronosyltransferase 1-60202
UDP-glucuronosyltransferase 1A1 0202
UDP-glucuronosyltransferase 1A40202
UDP-glucuronosyltransferase 2B10 0202
Chain B, Exotoxin A0011
Chain B, Exotoxin A0011
Chain B, Exotoxin A0011
Muscarinic acetylcholine receptor M10101
Muscarinic acetylcholine receptor M30101
Muscarinic acetylcholine receptor M40101
Muscarinic acetylcholine receptor M50101
Cytochrome P450 2D60505
Muscarinic acetylcholine receptor M20101
Histidine decarboxylase0011
D(3) dopamine receptor0202
Kappa-type opioid receptor0102
UDP-glucuronosyltransferase 1A80002
Atrial natriuretic peptide receptor 10101
pregnane X receptor2002
Glucocorticoid receptor0426
Glycine receptor subunit alpha-10404
Glycine receptor subunit beta0404
Glycine receptor subunit alpha-20404
Glycine receptor subunit alpha-30404
Solute carrier family 22 member 10101
Sterol O-acyltransferase 10101
Solute carrier family 22 member 20101
Solute carrier family 22 member 30101
Acetylcholinesterase 0101
DNA (cytosine-5)-methyltransferase 10101
Sterol O-acyltransferase 10101
Solute carrier family 22 member 40101
DNA (cytosine-5)-methyltransferase 3-like0101
DNA (cytosine-5)-methyltransferase 3A0101
ATP-binding cassette sub-family C member 90101
Cytochrome P450 1A20202
ATP-sensitive inward rectifier potassium channel 110101
Lanosterol 14-alpha demethylase0101
Nuclear receptor subfamily 2 group E member 10033
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Fatty-acid amide hydrolase 10101
UDP-glucuronosyltransferase 1A90001
Gamma-aminobutyric acid receptor subunit alpha-10001
Gamma-aminobutyric acid receptor subunit beta-10001
Gamma-aminobutyric acid receptor subunit alpha-20001
Gamma-aminobutyric acid receptor subunit alpha-30001
Gamma-aminobutyric acid receptor subunit alpha-10112
Gamma-aminobutyric acid receptor subunit beta-10011
Gamma-aminobutyric acid receptor subunit gamma-20112
Gamma-aminobutyric acid receptor subunit alpha-40001
Gamma-aminobutyric acid receptor subunit gamma-20001
Gamma-aminobutyric acid receptor subunit beta-30112
Gamma-aminobutyric acid receptor subunit alpha-50011
Gamma-aminobutyric acid receptor subunit alpha-30011
Gamma-aminobutyric acid receptor subunit alpha-20011
Gamma-aminobutyric acid receptor subunit beta-20011
Gamma-aminobutyric acid receptor subunit alpha-40011
Gamma-aminobutyric acid receptor subunit alpha-60011
5-hydroxytryptamine receptor 1A0101
Alpha-2C adrenergic receptor0124
Voltage-dependent L-type calcium channel subunit alpha-1C0101
5-hydroxytryptamine receptor 1B0213
Neuromedin-K receptor0011
Type-1 angiotensin II receptor0112
Cholecystokinin receptor type A0112
Cytochrome P450 2C190202
5-hydroxytryptamine receptor 70112
Histidine-rich protein PFHRP-II0101
Cytochrome P450 2D10101
Cytochrome P450 2D260101
Cytochrome P450 2D30101
Potassium voltage-gated channel subfamily A member 50101
Cholinesterase0101
Potassium voltage-gated channel subfamily D member 20101
Cytochrome P450 2D40101
Multidrug resistance protein 1a0001
nuclear receptor subfamily 1, group I, member 21001
Chain A, Mineralocorticoid receptor0101
Chain A, Mineralocorticoid receptor0101
Vpr1001
Estrogen receptor0213
Progesterone receptor0213
Mineralocorticoid receptor 0203
Estrogen receptor beta0112
Urease subunit alpha0101
Urease subunit beta0101
Olfactory receptor 51E20011
Proprotein convertase subtilisin/kexin type 70101
Vitamin K epoxide reductase complex subunit 1-like protein 10101
Vitamin K epoxide reductase complex subunit 10101
Protease 0101
Vitamin K epoxide reductase complex subunit 1-like protein 10101
Vitamin K epoxide reductase complex subunit 1 0202
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]