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toluenes
Any member of the class of benzenes that is a substituted benzene in which the substituents include one (and only one) methyl group.
ChEBI ID: 27024
Members (33)
| Member | Definition | Role |
|---|---|---|
| 1-(2-furanylmethyl)-3-[(4-methylphenyl)methyl]pyrrolidine-2,5-dione | 1-(2-furanylmethyl)-3-[(4-methylphenyl)methyl]pyrrolidine-2,5-dione | |
| 1,3-ditolylguanidine | 1,2-bis(2-methylphenyl)guanidine | |
| 2-(2-furanyl)-4-mercapto-3-(4-methylphenyl)-6-oxo-1,2-dihydropyrimidine-5-carbonitrile | 2-(2-furanyl)-4-mercapto-3-(4-methylphenyl)-6-oxo-1,2-dihydropyrimidine-5-carbonitrile | |
| 2-(4-methylphenyl)thiazolidine | 2-(4-methylphenyl)thiazolidine | |
| 2-[3-(2-methylphenyl)-4-oxo-2-thiazolidinylidene]propanedinitrile | 2-[3-(2-methylphenyl)-4-oxo-2-thiazolidinylidene]propanedinitrile | |
| 2-amino-7,7-dimethyl-4-(4-methylphenyl)-5-oxo-6,8-dihydro-4H-1-benzopyran-3-carbothioamide | 2-amino-7,7-dimethyl-4-(4-methylphenyl)-5-oxo-6,8-dihydro-4H-1-benzopyran-3-carbothioamide | |
| 2-Chloro-1-[3-(4-methylphenyl)-5-thiophen-2-yl-3,4-dihydropyrazol-2-yl]ethanone | 2-Chloro-1-[3-(4-methylphenyl)-5-thiophen-2-yl-3,4-dihydropyrazol-2-yl]ethanone | |
| 2-methoxy-N-[3-[4-[3-methyl-4-[(6-methyl-3-pyridinyl)oxy]anilino]-6-quinazolinyl]prop-2-enyl]acetamide | A member of the class of quinazolines that is quinazoline substituted by {3-methyl-4-[(6-methylpyridin-3-yl)oxy]phenyl}amino and 3-(2-methoxyacetamido)prop-1-en-1-yl groups at positions 4 and 6, respectively. | 2-methoxy-N-[3-[4-[3-methyl-4-[(6-methyl-3-pyridinyl)oxy]anilino]-6-quinazolinyl]prop-2-enyl]acetamide |
| 3-(4-methylphenyl)-2,1-benzoxazole-5-carboxaldehyde | 3-(4-methylphenyl)-2,1-benzoxazole-5-carboxaldehyde | |
| 3-(n,n-dimethylsulfonamido)-4-methyl-nitrobenzene | A C-nitro compound that is benzene substituted by N,N-dimethylaminosulfonyl, methyl and nitro groups at positions 1, 2 and 5, respectively. It is a phosphodiesterase inhibitor selective for the PDE7 subtype (Ki = 180 nM). | BRL-50481 |
| 3-ethyltoluene | A derivative of toluene bearing an additional ethyl substituent at position 3. | 3-ethyltoluene |
| 3,5-dimethoxytoluene | A member of the class of toluenes that is toluene in which the hydrogens at positions 3 and 5 have been replaced by methoxy groups. It is the major scent compound of many rose varieties. | 3,5-dimethoxytoluene |
| 4-cymene | A monoterpene that is toluene substituted by an isopropyl group at position 4. | p-cymene |
| 4-methylacetanilide | A member of the class of toluenes that is 4-aminotoluene in which one of the hydrogens attached to the amino group has been replaced by an acetyl group. | 4-acetamidotoluene |
| 4-toluenesulfonic acid | An arenesulfonic acid that is benzenesulfonic acid in which the hydrogen at position 4 is replaced by a methyl group. | toluene-4-sulfonic acid |
| 4-tolyl isocyanate | An isocyanate comprising a benzene core with isocyanato and methyl substituents para to each other. | 4-tolyl isocyanate |
| 5-(4-methylphenyl)-2-methylsulfonyl-3-thiophen-2-yl-3,4-dihydropyrazole | 5-(4-methylphenyl)-2-methylsulfonyl-3-thiophen-2-yl-3,4-dihydropyrazole | |
| 5-hydroxy-3-(4-methylphenyl)-5-(trifluoromethyl)-4H-pyrazole-1-carboxylic acid ethyl ester | 5-hydroxy-3-(4-methylphenyl)-5-(trifluoromethyl)-4H-pyrazole-1-carboxylic acid ethyl ester | |
| 5,6-dichloro-4-(4-methylphenyl)-1H-pyrazine-2,3-dione | 5,6-dichloro-4-(4-methylphenyl)-1H-pyrazine-2,3-dione | |
| aminocarb | A carbamate ester that is phenyl methylcarbamate substituted by a dimethylamino group at position 4 and a methyl group at position 3. | aminocarb |
| atomoxetine | A secondary amino compound having methyl and 3-(2-methylphenoxy)-3-phenylpropan-1-yl substituents. | atomoxetine |
| celecoxib | A member of the class of pyrazoles that is 1H-pyrazole which is substituted at positions 1, 3 and 5 by 4-sulfamoylphenyl, trifluoromethyl and p-tolyl groups, respectively. A cyclooxygenase-2 inhibitor, it is used in the treatment of arthritis. | celecoxib |
| Fezatione | Fezatione | |
| iFSP1 | A member of the class of pyridobenzimidazoles that is pyrido[1,2-a]benzimidazole substituted by amino, cyano, 4-methylphenyl, and cyano groups at positions 1, 2, 3 and 4, respectively. It is a potent inhibitor of ferroptosis suppressor protein 1 (FSP1) with EC50 of 103 nM. It induces ferroptosis in GPX4 knockout cells that overexpress FSP1. | iFSP1 |
| N-(4-methylphenyl)carbamic acid (cyclopentylideneamino) ester | N-(4-methylphenyl)carbamic acid (cyclopentylideneamino) ester | |
| N-[2-(1-cyclohexenyl)ethyl]-3-[(4-methylphenyl)methylthio]propanamide | N-[2-(1-cyclohexenyl)ethyl]-3-[(4-methylphenyl)methylthio]propanamide | |
| n-acetyl-2-toluidine | 2`-Methylacetanilide | |
| n-hydroxy-n'-(4-butyl-2-methylphenyl)formamidine | HET0016 | |
| N-methyl-2-(4-methylphenyl)-N-(1-methylpiperidin-4-yl)quinazolin-4-amine | A member of the class of quinazolines that is quinazoline which is substituted by a 4-methylphenyl group and a methyl(1-methylpiperidin-4-yl)nitrilo group at positions 2 and 4, respectively. | N-methyl-2-(4-methylphenyl)-N-(1-methylpiperidin-4-yl)quinazolin-4-amine |
| netupitant | A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoic acid with the secondary amino group of N-methyl-4-(2-methylphenyl)-6-(4-methylpiperazin-1-yl)pyridin-3-amine; an antiemetic used in combination with palonosetron hydrochloride (under the trade name Akynzeo) to treat nausea and vomiting in patients undergoing cancer chemotherapy. | netupitant |
| sr 11302 | A retinoid that is all-trans-retinoic acid in which the methyl group at position 9 is replaced by a 4-methylphenyl group. It is an inhibitor of activator protein-1 which exhibits antitumour effects in vivo. | SR11302 |
| toloxatone | A member of the class of oxazolidinones that is 5-(hydroxymethyl)-1,3-oxazolidin-2-one substituted by a 3-methylphenyl group at position 3. | 5-(hydroxymethyl)-3-(3-methylphenyl)-1,3-oxazolidin-2-one |
| toluene | The simplest member of the class toluenes consisting of a benzene core which bears a single methyl substituent. | toluene |
Research
Studies (14,639)
| Timeframe | Studies, Drugs in This Class (%) | All Drugs % |
|---|---|---|
| pre-1990 | 2,763 (18.87) | 18.7374 |
| 1990's | 1,268 (8.66) | 18.2507 |
| 2000's | 4,541 (31.02) | 29.6817 |
| 2010's | 4,771 (32.59) | 24.3611 |
| 2020's | 1,296 (8.85) | 2.80 |
Study Types
| Publication Type | Studies, Drugs in This Class (%) | All Drugs (%) |
|---|---|---|
| Trials | 949 (6.09%) | 5.53% |
| Reviews | 739 (4.74%) | 6.00% |
| Case Studies | 490 (3.15%) | 4.05% |
| Observational | 16 (0.10%) | 0.25% |
| Other | 13,384 (85.92%) | 84.16% |