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toluenes

Any member of the class of benzenes that is a substituted benzene in which the substituents include one (and only one) methyl group.

ChEBI ID: 27024

Members (33)

MemberDefinitionRole
1-(2-furanylmethyl)-3-[(4-methylphenyl)methyl]pyrrolidine-2,5-dione1-(2-furanylmethyl)-3-[(4-methylphenyl)methyl]pyrrolidine-2,5-dione
1,3-ditolylguanidine1,2-bis(2-methylphenyl)guanidine
2-(2-furanyl)-4-mercapto-3-(4-methylphenyl)-6-oxo-1,2-dihydropyrimidine-5-carbonitrile2-(2-furanyl)-4-mercapto-3-(4-methylphenyl)-6-oxo-1,2-dihydropyrimidine-5-carbonitrile
2-(4-methylphenyl)thiazolidine2-(4-methylphenyl)thiazolidine
2-[3-(2-methylphenyl)-4-oxo-2-thiazolidinylidene]propanedinitrile2-[3-(2-methylphenyl)-4-oxo-2-thiazolidinylidene]propanedinitrile
2-amino-7,7-dimethyl-4-(4-methylphenyl)-5-oxo-6,8-dihydro-4H-1-benzopyran-3-carbothioamide2-amino-7,7-dimethyl-4-(4-methylphenyl)-5-oxo-6,8-dihydro-4H-1-benzopyran-3-carbothioamide
2-Chloro-1-[3-(4-methylphenyl)-5-thiophen-2-yl-3,4-dihydropyrazol-2-yl]ethanone2-Chloro-1-[3-(4-methylphenyl)-5-thiophen-2-yl-3,4-dihydropyrazol-2-yl]ethanone
2-methoxy-N-[3-[4-[3-methyl-4-[(6-methyl-3-pyridinyl)oxy]anilino]-6-quinazolinyl]prop-2-enyl]acetamideA member of the class of quinazolines that is quinazoline substituted by {3-methyl-4-[(6-methylpyridin-3-yl)oxy]phenyl}amino and 3-(2-methoxyacetamido)prop-1-en-1-yl groups at positions 4 and 6, respectively.2-methoxy-N-[3-[4-[3-methyl-4-[(6-methyl-3-pyridinyl)oxy]anilino]-6-quinazolinyl]prop-2-enyl]acetamide
3-(4-methylphenyl)-2,1-benzoxazole-5-carboxaldehyde3-(4-methylphenyl)-2,1-benzoxazole-5-carboxaldehyde
3-(n,n-dimethylsulfonamido)-4-methyl-nitrobenzeneA C-nitro compound that is benzene substituted by N,N-dimethylaminosulfonyl, methyl and nitro groups at positions 1, 2 and 5, respectively. It is a phosphodiesterase inhibitor selective for the PDE7 subtype (Ki = 180 nM).BRL-50481
3-ethyltolueneA derivative of toluene bearing an additional ethyl substituent at position 3.3-ethyltoluene
3,5-dimethoxytolueneA member of the class of toluenes that is toluene in which the hydrogens at positions 3 and 5 have been replaced by methoxy groups. It is the major scent compound of many rose varieties.3,5-dimethoxytoluene
4-cymeneA monoterpene that is toluene substituted by an isopropyl group at position 4.p-cymene
4-methylacetanilideA member of the class of toluenes that is 4-aminotoluene in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.4-acetamidotoluene
4-toluenesulfonic acidAn arenesulfonic acid that is benzenesulfonic acid in which the hydrogen at position 4 is replaced by a methyl group.toluene-4-sulfonic acid
4-tolyl isocyanateAn isocyanate comprising a benzene core with isocyanato and methyl substituents para to each other.4-tolyl isocyanate
5-(4-methylphenyl)-2-methylsulfonyl-3-thiophen-2-yl-3,4-dihydropyrazole5-(4-methylphenyl)-2-methylsulfonyl-3-thiophen-2-yl-3,4-dihydropyrazole
5-hydroxy-3-(4-methylphenyl)-5-(trifluoromethyl)-4H-pyrazole-1-carboxylic acid ethyl ester5-hydroxy-3-(4-methylphenyl)-5-(trifluoromethyl)-4H-pyrazole-1-carboxylic acid ethyl ester
5,6-dichloro-4-(4-methylphenyl)-1H-pyrazine-2,3-dione5,6-dichloro-4-(4-methylphenyl)-1H-pyrazine-2,3-dione
aminocarbA carbamate ester that is phenyl methylcarbamate substituted by a dimethylamino group at position 4 and a methyl group at position 3.aminocarb
atomoxetineA secondary amino compound having methyl and 3-(2-methylphenoxy)-3-phenylpropan-1-yl substituents.atomoxetine
celecoxibA member of the class of pyrazoles that is 1H-pyrazole which is substituted at positions 1, 3 and 5 by 4-sulfamoylphenyl, trifluoromethyl and p-tolyl groups, respectively. A cyclooxygenase-2 inhibitor, it is used in the treatment of arthritis.celecoxib
FezationeFezatione
iFSP1A member of the class of pyridobenzimidazoles that is pyrido[1,2-a]benzimidazole substituted by amino, cyano, 4-methylphenyl, and cyano groups at positions 1, 2, 3 and 4, respectively. It is a potent inhibitor of ferroptosis suppressor protein 1 (FSP1) with EC50 of 103 nM. It induces ferroptosis in GPX4 knockout cells that overexpress FSP1.iFSP1
N-(4-methylphenyl)carbamic acid (cyclopentylideneamino) esterN-(4-methylphenyl)carbamic acid (cyclopentylideneamino) ester
N-[2-(1-cyclohexenyl)ethyl]-3-[(4-methylphenyl)methylthio]propanamideN-[2-(1-cyclohexenyl)ethyl]-3-[(4-methylphenyl)methylthio]propanamide
n-acetyl-2-toluidine2`-Methylacetanilide
n-hydroxy-n'-(4-butyl-2-methylphenyl)formamidineHET0016
N-methyl-2-(4-methylphenyl)-N-(1-methylpiperidin-4-yl)quinazolin-4-amineA member of the class of quinazolines that is quinazoline which is substituted by a 4-methylphenyl group and a methyl(1-methylpiperidin-4-yl)nitrilo group at positions 2 and 4, respectively.N-methyl-2-(4-methylphenyl)-N-(1-methylpiperidin-4-yl)quinazolin-4-amine
netupitantA monocarboxylic acid amide obtained by formal condensation of the carboxy group of 2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoic acid with the secondary amino group of N-methyl-4-(2-methylphenyl)-6-(4-methylpiperazin-1-yl)pyridin-3-amine; an antiemetic used in combination with palonosetron hydrochloride (under the trade name Akynzeo) to treat nausea and vomiting in patients undergoing cancer chemotherapy.netupitant
sr 11302A retinoid that is all-trans-retinoic acid in which the methyl group at position 9 is replaced by a 4-methylphenyl group. It is an inhibitor of activator protein-1 which exhibits antitumour effects in vivo.SR11302
toloxatoneA member of the class of oxazolidinones that is 5-(hydroxymethyl)-1,3-oxazolidin-2-one substituted by a 3-methylphenyl group at position 3.5-(hydroxymethyl)-3-(3-methylphenyl)-1,3-oxazolidin-2-one
tolueneThe simplest member of the class toluenes consisting of a benzene core which bears a single methyl substituent.toluene

Research

Studies (14,639)

TimeframeStudies, Drugs in This Class (%)All Drugs %
pre-19902,763 (18.87)18.7374
1990's1,268 (8.66)18.2507
2000's4,541 (31.02)29.6817
2010's4,771 (32.59)24.3611
2020's1,296 (8.85)2.80

Study Types

Publication TypeStudies, Drugs in This Class (%)All Drugs (%)
Trials949 (6.09%)5.53%
Reviews739 (4.74%)6.00%
Case Studies490 (3.15%)4.05%
Observational16 (0.10%)0.25%
Other13,384 (85.92%)84.16%