ascorbic-acid and Keratosis

Topics: Adult; Ascorbic Acid; Carbon Isotopes; Clinical Trials as Topic; Diet; Electrocardiography; Electroencephalography; Enteral Nutrition; Eye Diseases; Feces; Glucose Tolerance Test; Hematology; Hemorrhage; Humans; Keratosis; Male; Nutritional Physiological Phenomena; Nutritional Requirements; Oral Hemorrhage; Scurvy; Skin Diseases; Urine

Topics: Aged; Alcoholism; Ascorbic Acid; Dermoscopy; Erythrocytes; Fibrosis; Fruit; Hair Follicle; Humans; Keratosis; Male; Malnutrition; Mouth, Edentulous; Purpura; Remission Induction; Scurvy; Skin Pigmentation; Vegetables

Reactive oxygen species and lipid peroxides have been implicated in the pathogenesis of a variety of diseases, particularly cancer. There may be an inverse correlation between lipid peroxidation and antioxidant defense mechanisms. The aim of this study was to investigate whether certain plasma antioxidants (ascorbic acid, alpha-tocopherol, total thiol groups, ceruloplasmin, urate, albumin and erythrocyte glutathione) are altered in actinic keratosis (AK) and basal cell carcinoma (BCC).. Plasma samples and red blood cells (RBC) of 13 patients with AK, 12 with BCC and 16 healthy controls were investigated.. Data analysis indicates significant decrease of ascorbic acid (P < 0.001), alpha-tocopherol (P < 0.05 and P < 0.001), total thiol groups (P < 0.001), ceruloplasmin (P < 0.001 and P < 0.05), and RBC glutathione (P < 0.05) values in both AK and BCC groups compared to controls. Comparison of AK and BCC groups evidenced a significant decrease of alpha-tocopherol and RBC glutathione (P < 0.05) in BCC patient.. Plasma antioxidants are decreased in the AK and BCC, probably due to the long exposure to UV irradiation which is one of the most important factors in the etiology of AK and BCC and alpha-tocopherol and RBC glutathione (P < 0.05) are most altered in BCC.

Topics: Adult; Aged; Antioxidants; Ascorbic Acid; Carcinoma, Basal Cell; Ceruloplasmin; Erythrocytes; Female; Glutathione; Humans; Keratosis; Male; Middle Aged; Reference Values; Serum Albumin; Skin Neoplasms; Sulfhydryl Compounds; Uric Acid; Vitamin E

A 9-year-old girl had the insidious development of lethargy, gingival erosions, and follicular hyperkeratosis with perifollicular hemorrhage. A dietary history disclosed that she consumed only one kind of sandwich and beverage and took no other foods. A skin biopsy specimen was consistent with the diagnosis of scurvy, and marked improvement occurred with ascorbic acid therapy. Although it is an uncommon disorder in the United States, scurvy may occur in persons with prolonged and peculiar dietary habits.

Topics: Ascorbic Acid; Child; Feeding Behavior; Female; Folliculitis; Gingiva; Gingivitis; Hemorrhage; Humans; Keratosis; Leg; Scurvy

Topics: Adult; Antigens; Ascorbic Acid; Blood Glucose; Blood Protein Disorders; Body Weight; Carbon Isotopes; Cholesterol; Diet Therapy; Epinephrine; Epithelium; Fatigue; Gingival Diseases; Hemorrhage; Humans; Immunization; Insulin; Joint Diseases; Keratosis; Lipids; Male; Middle Aged; Muscular Diseases; Nutritional Requirements; Pain; Plasma; Scurvy; Time Factors; Typhoid Fever; Water

Topics: Adult; Ascorbic Acid; Black People; Dental Caries Susceptibility; Fatty Acids; Gingivitis; Health Surveys; Humans; Keratosis; Male; Middle Aged; Nicotinic Acids; Pellagra; Riboflavin Deficiency; Rural Population; Skin Diseases; South Africa; Urban Population; Vitamin A Deficiency

Topics: Ascorbic Acid; Humans; Keratosis; Skin Diseases; Vitamin A; Vitamin B Complex; Vitamins

Topics: Adult; Aged; Ascorbic Acid; Ascorbic Acid Deficiency; Chronic Disease; Depression; Diet; Diet Therapy; Edema; Female; Hemorrhage; Humans; Keratosis; Middle Aged; Scurvy

Topics: Aged; Angiomatosis; Arteriosclerosis; Ascorbic Acid; Glomerulonephritis; Humans; Hypertension; Keratosis; Male; Nails; Pressure; Purpura