Page last updated: 2024-08-05 15:21:29

fixative

Any compound used for the purpose of preserving biological tissues from decay in such a way as to allow for the preparation of thin, stained sections for subsequent histological study.

ChEBI ID: 50913

Members (4)

MemberDefinitionClass
benzyl cinnamateThe cinnamate ester derived from cinnamic acid and benzyl alcohol. Occuring in Balsam of Peru and Tolu balsam, in Sumatra and Penang benzoin, and as the main constituent of copaiba balsam, it is used in heavy oriental perfumes, as a fixative and as a flavouring agent.benzyl cinnamate
glutaralA dialdehyde comprised of pentane with aldehyde functions at C-1 and C-5.glutaraldehyde
osmium tetroxideAn osmium coordination entity consisting of four oxygen atoms bound to a central osmium atom via covalent double bonds.osmium tetroxide
picric acidA C-nitro compound comprising phenol having three nitro substtituents at the 2-, 4- and 6-positions.picric acid

Research

Studies (8,007)

TimeframeStudies, Drugs with This Role(%)All Drugs %
pre-19903,094 (38.64)18.7374
1990's1,728 (21.58)18.2507
2000's1,365 (17.05)29.6817
2010's1,373 (17.15)24.3611
2020's447 (5.58)2.80

Study Types

Publication TypeStudies, Drugs with this Role (%)All Drugs (%)
Trials156 (1.79%)5.53%
Reviews213 (2.44%)6.00%
Case Studies148 (1.70%)4.05%
Observational0 (0.00%)0.25%
Other8,212 (94.08%)84.16%

Protein Targets (41)

Potency Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
activating transcription factor 6Homo sapiens (human)Potency43.462324
AR proteinHomo sapiens (human)Potency43.417756
aryl hydrocarbon receptorHomo sapiens (human)Potency26.603211
Ataxin-2Homo sapiens (human)Potency42.316913
ATPase family AAA domain-containing protein 5Homo sapiens (human)Potency46.478024
Cellular tumor antigen p53Homo sapiens (human)Potency41.809738
cytochrome P450 2C9, partialHomo sapiens (human)Potency12.301811
cytochrome P450 family 3 subfamily A polypeptide 4Homo sapiens (human)Potency3.682222
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_aHomo sapiens (human)Potency47.093812
estrogen nuclear receptor alphaHomo sapiens (human)Potency41.8023815
estrogen-related nuclear receptor alphaHomo sapiens (human)Potency22.1360612
euchromatic histone-lysine N-methyltransferase 2Homo sapiens (human)Potency31.622811
farnesoid X nuclear receptorHomo sapiens (human)Potency26.601111
GVesicular stomatitis virusPotency12.301811
GLI family zinc finger 3Homo sapiens (human)Potency6.955023
glucocorticoid receptor [Homo sapiens]Homo sapiens (human)Potency35.065622
Glutamate receptor 2Rattus norvegicus (Norway rat)Potency15.157712
HLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)Potency12.301811
hypoxia-inducible factor 1 alpha subunitHomo sapiens (human)Potency59.449111
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)Homo sapiens (human)Potency39.810711
Inositol hexakisphosphate kinase 1Homo sapiens (human)Potency12.301812
Interferon betaHomo sapiens (human)Potency12.301811
interleukin 8Homo sapiens (human)Potency74.978011
lamin isoform A-delta10Homo sapiens (human)Potency0.035511
LuciferasePhotinus pyralis (common eastern firefly)Potency13.994323
nuclear factor erythroid 2-related factor 2 isoform 1Homo sapiens (human)Potency32.722337
Nuclear receptor ROR-gammaHomo sapiens (human)Potency33.491511
nuclear receptor subfamily 1, group I, member 3Homo sapiens (human)Potency11.990036
peroxisome proliferator activated receptor gammaHomo sapiens (human)Potency43.473858
potassium voltage-gated channel subfamily H member 2 isoform dHomo sapiens (human)Potency24.803312
RAR-related orphan receptor gammaMus musculus (house mouse)Potency25.078827
retinoic acid nuclear receptor alpha variant 1Homo sapiens (human)Potency18.803736
retinoid X nuclear receptor alphaHomo sapiens (human)Potency14.204524
Spike glycoproteinSevere acute respiratory syndrome-related coronavirusPotency5.011911
TDP1 proteinHomo sapiens (human)Potency3.349811
thyroid hormone receptor beta isoform 2Rattus norvegicus (Norway rat)Potency26.337011
thyroid stimulating hormone receptorHomo sapiens (human)Potency7.695922
USP1 protein, partialHomo sapiens (human)Potency33.117012
v-jun sarcoma virus 17 oncogene homolog (avian)Homo sapiens (human)Potency29.795111
Voltage-dependent calcium channel gamma-2 subunitMus musculus (house mouse)Potency15.157712

Inhibition Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
17beta-hydroxysteroid dehydrogenaseCurvularia lunataIC503.850022