An agonist that selectively binds to and activates a protein kinase G receptor.
ChEBI ID: 64105
| Member | Definition | Class |
|---|---|---|
| 8-bromocyclic gmp | A 3',5'-cyclic purine nucleotide that is 3',5'-cyclic GMP bearing an additional bromo substituent at position 8 on the guanine ring. A membrane permeable cGMP analogue that activates protein kinase G (PKG). It is 4.3-fold more potent than cGMP in activating PKG1alpha and promotes relaxation of tracheal and vascular smooth muscle tissue in vitro. | 8-bromo-3',5'-cyclic GMP |
| 8-bromocyclic gmp, sodium salt | An organic sodium salt having 8-bromoguanosine 3',5'-cyclic phosphate as the counterion. A membrane permeable cGMP analogue that activates protein kinase G (PKG). It is 4.3-fold more potent than cGMP in activating PKG1alpha and promotes relaxation of tracheal and vascular smooth muscle tissue in vitro. | sodium 8-bromo-3',5'-cyclic GMP |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 205 (13.70) | 18.7374 |
| 1990's | 671 (44.85) | 18.2507 |
| 2000's | 505 (33.76) | 29.6817 |
| 2010's | 109 (7.29) | 24.3611 |
| 2020's | 6 (0.40) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 2 (0.13%) | 5.53% |
| Reviews | 8 (0.53%) | 6.00% |
| Case Studies | 1 (0.07%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 1,512 (99.28%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| geminin | Homo sapiens (human) | Potency | 1.0000 | 1 | 1 |
| nuclear factor erythroid 2-related factor 2 isoform 2 | Homo sapiens (human) | Potency | 0.4611 | 1 | 1 |
| Rap guanine nucleotide exchange factor 4 | Homo sapiens (human) | Potency | 5.6234 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| cAMP-dependent protein kinase catalytic subunit beta isoform 1 | Mus musculus (house mouse) | EC50 | 7.8270 | 2 | 2 |
| cAMP-dependent protein kinase catalytic subunit beta isoform 3 | Homo sapiens (human) | EC50 | 2.1550 | 2 | 2 |
| cAMP-dependent protein kinase type I-alpha regulatory subunit | Bos taurus (cattle) | EC50 | 7.8270 | 2 | 2 |
| cAMP-dependent protein kinase type II-beta regulatory subunit | Homo sapiens (human) | EC50 | 2.1550 | 2 | 2 |