ascorbic-acid and fludarabine

ascorbic-acid has been researched along with fludarabine* in 1 studies

Other Studies

1 other study(ies) available for ascorbic-acid and fludarabine

Article	Year
Oxidative stress and delta-ALA-D activity in different conditioning regimens in allogeneic bone marrow transplantation patients. Clinical biochemistry, 2009, Volume: 42, Issue:7-8 To compare different conditioning regimens (CR), in order to determine whether either of them could be less toxic to allogeneic bone marrow transplantation (BMT) patients in terms of oxidative stress and also analyze delta-ALA-D activity as a possible marker of oxidative stress.. Lipid peroxidation, vitamin C, thiol groups levels and catalase, superoxide dismutase and delta-ALA-D activity were determined in 21 healthy controls, 5 patients with fludarabine+cyclophosphamide (FluCy) CR, 12 with busulfan+cyclophosphamide (BuCy) and 4 with cyclophosphamide+total body irradiation (CyTBI).. There were a decrease in enzymatic and non enzymatic antioxidants, in delta-ALA-D activity, and in all CRs and an increase in lipid peroxidation more pronounced in CyTBI CR.. All CRs promoted oxidative stress in allogeneic BMT patients, but this was more pronounced with CyTBI and delta-ALA-D activity seemed to be an additional biomarker of oxidative stress in these patients. Topics: Adult; Antioxidants; Ascorbic Acid; Bone Marrow Transplantation; Catalase; Cyclophosphamide; Enzyme Activation; Female; Humans; Lipid Peroxidation; Male; Middle Aged; Oxidative Stress; Porphobilinogen Synthase; Superoxide Dismutase; Vidarabine	2009

Article

Year

Oxidative stress and delta-ALA-D activity in different conditioning regimens in allogeneic bone marrow transplantation patients.

Clinical biochemistry, 2009, Volume: 42, Issue:7-8

To compare different conditioning regimens (CR), in order to determine whether either of them could be less toxic to allogeneic bone marrow transplantation (BMT) patients in terms of oxidative stress and also analyze delta-ALA-D activity as a possible marker of oxidative stress.. Lipid peroxidation, vitamin C, thiol groups levels and catalase, superoxide dismutase and delta-ALA-D activity were determined in 21 healthy controls, 5 patients with fludarabine+cyclophosphamide (FluCy) CR, 12 with busulfan+cyclophosphamide (BuCy) and 4 with cyclophosphamide+total body irradiation (CyTBI).. There were a decrease in enzymatic and non enzymatic antioxidants, in delta-ALA-D activity, and in all CRs and an increase in lipid peroxidation more pronounced in CyTBI CR.. All CRs promoted oxidative stress in allogeneic BMT patients, but this was more pronounced with CyTBI and delta-ALA-D activity seemed to be an additional biomarker of oxidative stress in these patients.

Topics: Adult; Antioxidants; Ascorbic Acid; Bone Marrow Transplantation; Catalase; Cyclophosphamide; Enzyme Activation; Female; Humans; Lipid Peroxidation; Male; Middle Aged; Oxidative Stress; Porphobilinogen Synthase; Superoxide Dismutase; Vidarabine

2009