Compounds > siphonodictyal b1
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siphonodictyal b1

Description

siphonodictyal B1: isolated from Siphonodictyon coralliphagum; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID135625497
CHEMBL ID222633
MeSH IDM0549974

Synonyms (2)

Synonym
CHEMBL222633
siphonodictyal b1

Research Excerpts

Overview

Siphonodictyal B1 is a sesquiterpene-hydroquinone isolated from the Caribbean coral reef bioeroding sponge.

ExcerptReference
"Siphonodictyal B1 is a sesquiterpene-hydroquinone isolated from the Caribbean coral reef bioeroding sponge Siphonodictyon coralliphagum. "( Siphonodictyal B1 from a marine sponge increases intracellular calcium levels comparable to the Ca2+-ATPase (SERCA) inhibitor thapsigargin.
Bickmeyer, U; Grube, A; Klings, KW; Köck, M; Pawlik, JR, 2010)
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (15)

Assay IDTitleYearJournalArticle
AID283706Antimicrobial activity against Saccharomyces cerevisiae at 20 ug by agar diffusion test2007Journal of natural products, Apr, Volume: 70, Issue:4
Bioactive metabolites from the Caribbean sponge Aka coralliphagum.
AID283711Antimicrobial activity against Pythium debaryanum at 20 ug by agar diffusion test2007Journal of natural products, Apr, Volume: 70, Issue:4
Bioactive metabolites from the Caribbean sponge Aka coralliphagum.
AID283708Antimicrobial activity against Botrytis cinerea at 20 ug by agar diffusion test2007Journal of natural products, Apr, Volume: 70, Issue:4
Bioactive metabolites from the Caribbean sponge Aka coralliphagum.
AID283698Antimicrobial activity against Escherichia coli tolC at 20 ug by agar diffusion test2007Journal of natural products, Apr, Volume: 70, Issue:4
Bioactive metabolites from the Caribbean sponge Aka coralliphagum.
AID283703Antimicrobial activity against Staphylococcus aureus at 20 ug by agar diffusion test2007Journal of natural products, Apr, Volume: 70, Issue:4
Bioactive metabolites from the Caribbean sponge Aka coralliphagum.
AID283697DPPH radical scavenging activity at 200 umol/L relative to control2007Journal of natural products, Apr, Volume: 70, Issue:4
Bioactive metabolites from the Caribbean sponge Aka coralliphagum.
AID283699Antimicrobial activity against Klebsiella pneumoniae at 20 ug by agar diffusion test2007Journal of natural products, Apr, Volume: 70, Issue:4
Bioactive metabolites from the Caribbean sponge Aka coralliphagum.
AID283705DPPH radical scavenging activity at 40 umol/L relative to control2007Journal of natural products, Apr, Volume: 70, Issue:4
Bioactive metabolites from the Caribbean sponge Aka coralliphagum.
AID283701Antimicrobial activity against Micrococcus luteus at 20 ug by agar diffusion test2007Journal of natural products, Apr, Volume: 70, Issue:4
Bioactive metabolites from the Caribbean sponge Aka coralliphagum.
AID283702Antimicrobial activity against Mycobacterium phlei at 20 ug by agar diffusion test2007Journal of natural products, Apr, Volume: 70, Issue:4
Bioactive metabolites from the Caribbean sponge Aka coralliphagum.
AID283700Antimicrobial activity against Pseudomonas aeruginosa at 20 ug by agar diffusion test2007Journal of natural products, Apr, Volume: 70, Issue:4
Bioactive metabolites from the Caribbean sponge Aka coralliphagum.
AID283710Antimicrobial activity against Hansenula anomala at 20 ug by agar diffusion test2007Journal of natural products, Apr, Volume: 70, Issue:4
Bioactive metabolites from the Caribbean sponge Aka coralliphagum.
AID283707Antimicrobial activity against Aspergillus fumigatus at 20 ug by agar diffusion test2007Journal of natural products, Apr, Volume: 70, Issue:4
Bioactive metabolites from the Caribbean sponge Aka coralliphagum.
AID283704Antimicrobial activity against Candida albicans at 20 ug by agar diffusion test2007Journal of natural products, Apr, Volume: 70, Issue:4
Bioactive metabolites from the Caribbean sponge Aka coralliphagum.
AID283709Cytotoxicity against mouse L929 cells by MTT assay2007Journal of natural products, Apr, Volume: 70, Issue:4
Bioactive metabolites from the Caribbean sponge Aka coralliphagum.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (20.00)29.6817
2010's4 (80.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
palladium
Palladium: A chemical element having an atomic weight of 106.4, atomic number of 46, and the symbol Pd. It is a white, ductile metal resembling platinum, and following it in abundance and importance of applications. It is used in dentistry in the form of gold, silver, and copper alloys.. palladium : Chemical element (nickel group element atom) with atomic number 46.		2.1710metal allergen;
nickel group element atom;
platinum group metal atom
thapsigargin
Thapsigargin: A sesquiterpene lactone found in roots of THAPSIA. It inhibits SARCOPLASMIC RETICULUM CALCIUM-TRANSPORTING ATPASES.. thapsigargin : An organic heterotricyclic compound that is a hexa-oxygenated 6,7-guaianolide isolated fron the roots of Thapsia garganica L., Apiaceae. A potent skin irritant, it is used in traditional medicine as a counter-irritant. Thapsigargin inhibits Ca(2+)-transporting ATPase mediated uptake of calcium ions into sarcoplasmic reticulum and is used in experimentation examining the impacts of increasing cytosolic calcium concentrations.		7.0510butyrate ester;
organic heterotricyclic compound;
sesquiterpene lactone		calcium channel blocker;
EC 3.6.3.8 (Ca(2+)-transporting ATPase) inhibitor
sesquiterpenes
[no description available]		3.0340
sclareolide
sclareolide: has antineoplastic activity; synthesized by oxidation of sclareol; a minor constituent of Arnica angustifolia and Sideritis nutans; structure in first source		2.2110
liphagal
liphagal: selective inhibitor of PI3 kinase alpha isolated from the sponge akacoralliphaga; structure in first source. liphagal : A meroterpenoid isolated from the marine sponge Aka coralliphaga and has been shown to exhibit inhibitory activity against phosphatidylinositol-3-OH kinase.		2.8530aldehyde;
cyclic ether;
meroterpenoid;
organic heterotetracyclic compound;
polyphenol		EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor;
metabolite
ascorbic acid
Ascorbic Acid: A six carbon compound related to glucose. It is found naturally in citrus fruits and many vegetables. Ascorbic acid is an essential nutrient in human diets, and necessary to maintain connective tissue and bone. Its biologically active form, vitamin C, functions as a reducing agent and coenzyme in several metabolic pathways. Vitamin C is considered an antioxidant.. L-ascorbic acid : The L-enantiomer of ascorbic acid and conjugate acid of L-ascorbate.. L-ascorbate : The L-enantiomer of ascorbate and conjugate base of L-ascorbic acid, arising from selective deprotonation of the 3-hydroxy group. Required for a range of essential metabolic reactions in all animals and plants.. vitamin C : Any member of a group of vitamers that belong to the chemical structural class called butenolides that exhibit biological activity against vitamin C deficiency in animals. The vitamers include L-ascorbic acid and its salt, ionized and oxidized forms.		2.0310ascorbic acid;
vitamin C		coenzyme;
cofactor;
flour treatment agent;
food antioxidant;
food colour retention agent;
geroprotector;
plant metabolite;
skin lightening agent
ConditionIndicatedRelationship StrengthStudiesTrials