Any pathological condition where fibrous connective tissue invades any organ, usually as a consequence of inflammation or other injury.
| Excerpt | Reference |
|---|
| "Myocardial fibrosis is an important determinant of pathological hypertrophy." | ( Brilla, CG; Weber, KT, 1992) |
| "Reactive fibrosis is associated with elevations in plasma aldosterone concentrations that are inappropriate relative to dietary sodium intake." | ( Brilla, CG; Weber, KT, 1992) |
| "Pulmonary fibrosis is an irreversible accumulation of connective tissue in the interstitium of the lung." | ( Greenberg, AH; Khalil, N, 1991) |
| "Interstitial fibrosis is a frequent finding in biopsies from long-term renal allografts, and may be due to chronic cyclosporine nephrotoxicity or chronic rejection." | ( Backman, U; Bohman, SO; Hemmingsson, A; Jennerholm, S; Nyman, R, 1990) |
| "Endometrial fibrosis is a major cause of infertility in broodmares." | ( Frazer, GS; Rossol, TJ; Threlfall, WR; Weisbrode, SE, 1988) |
| "Myocardial fibrosis is characterized by a pathological accumulation of types I and III collagens." | ( Appay, MD; Bariety, J; Heudes, D; Hinglais, N; Michel, JB; Nicoletti, A; Philippe, M; Sassy-Prigent, C, 1995) |
| "Tissue fibrosis is a common and serious consequence of chronic inflammation." | ( Cook, HT; Shaw, RJ; Taylor, GM; Wangoo, A, 1995) |
| "Myocardial fibrosis is a characteristic late feature in cases of viral myocarditis that progress to dilated cardiomyopathy." | ( Abelmann, WH; Dvorak, HF; Kishimoto, C; Owings, DV; Schnitt, SJ; Stillman, IE, 1993) |
| "Fibrosis is the pathologic hallmark of many common diseases." | ( Jimenez, SA; Varga, J, 1995) |
| "The reactive fibrosis is thought to be related to MC excess, while cell loss and microscopic scarring may be secondary to enhanced potassium excretion or a cytotoxic effect of aldosterone." | ( Campbell, SE; Janicki, JS; Matsubara, BB; Weber, KT, 1993) |
| "Subretinal fibrosis is an infrequent complication of diabetic macular edema." | ( Davis, MD; Ferris, FL; Fong, DS; Hubbard, LD; Myers, F; Segal, PP, 1997) |
| "Penile fibrosis is hence a significant complication of intracavernosal PGE1 therapy." | ( Chew, KK; Dhaliwal, SS; Earle, CM; Keogh, EJ; Stuckey, BG, 1997) |
| "Tubulointerstitial fibrosis is one of the most important histologic features that predicts progression in kidney disease." | ( Couser, WG; Hugo, C; Johnson, RJ; Pichler, RH; Shankland, SJ, 1998) |
| "1." | ( Nagler, A; Pines, M, 1998) |
| "The capsular fibrosis is presumably caused by accumulation of fibrin and proliferation stimulating factors in the narrow space between intraocular lens and air/SF6-gas bubble." | ( Jacobi, KW; Pavlovic, S; Scharwey, K, 1998) |
| "Cardiac fibrosis is linked to aldosterone-induced hypertension, but the effects on in vivo left ventricular (LV) function are not established." | ( Charlemagne, D; Delcayre, C; Lechat, P; Mougenot, N; Ramirez-Gil, JF; Robert, V; Trouve, P; Wassef, M, 1998) |
| "Serosal fibrosis is a rarely reported adverse effect of pergolide treatment, although it is well described with other dopamine agonists." | ( Dick, DJ; Pilling, JB; Shaunak, S; Wilkins, A, 1999) |
| "This massive fibrosis is associated with an increase in pancreatic size and weight." | ( Adler, G; Klöppel, G; Schmid, RM; Wagner, M, 1999) |
| "Tubulointerstitial fibrosis is a common end-point of many chronic renal diseases and contributes to the permanent loss of renal function." | ( Stahl, RA; Wolf, G; Ziyadeh, FN, 1999) |
| "Fibrosis is also an important phenomenon in patients with chronic pancreatitis (CP)." | ( Basso, D; De Paoli, M; Floreani, A; Fogar, P; Melis, A; Pasquali, C; Pedrazzoli, S; Piva, MG; Plebani, M; Sperti, C, 1998) |
| "Radiation fibrosis is a frequent sequel of therapeutic or accidental radiation overexposure in normal human tissues." | ( Delanian, S; Lefaix, J; Martin, M, 2000) |
| "Periaortic fibrosis is less frequent." | ( Bartoli, JM; De Roux, C; Disdier, P; Granel, B; Pellissier, JF; Serratrice, J; Swiader, L; Weiller, PJ, 2000) |
| "Tubulointerstitial fibrosis is a major component of several kidney diseases associated with the progression to end-stage renal failure." | ( Guo, G; Hruska, KA; Klahr, S; Liapis, H; Loveday, K; Martin, D; Miller, S; Morrissey, J; Sampath, TK; Wozniak, M, 2000) |
| "This interstitial fibrosis is an important determinant of pathologic hypertrophy in chronic heart failure." | ( Brilla, CG, 2000) |
| "Because progressive fibrosis is a histological hallmark of the aging kidney, we sought to characterize the course of some fibrosis-related genes [pro-alpha2(I)collagen (COL-I), pro-alpha1(III)collagen (COL-III), and transforming growth factors beta1 and beta3 (TGF-beta1 and TGF-beta3)] of interstitial collagen accumulation [COL-I and COL-III proteins, hydroxyproline (PRO-OH), histology] and its degradation (matrix metalloproteinase MMP-1 and -2) during maturation and early aging in rats." | ( Annoni, G; Arosio, B; Balestrieri, MR; Gagliano, N; Masson, S; Padoani, G; Santambrogio, D; Tagliabue, J; Vergani, C, 2000) |
| "Development of fibrosis is paralleled by increased expression of desmin and alpha-smooth muscle actin." | ( Ceyssens, B; De Bleser, P; De Craemer, D; Geerts, A; Hellemans, K; Pauwels, M; Van den Branden, C; Vanden Houte, K; Verbeelen, D, 2000) |
| "Skin fibrosis is characterized by the proliferation and accumulation of activated fibroblasts called myofibroblasts." | ( Delanian, S; Gault, N; Geffrotin, C; Lefaix, JL; Martin, M; Renard, C; Sivan, V; Vozenin-Brotons, MC, 2001) |
| "Epidural fibrosis is among the most common causes of FBSS, and it is often recalcitrant to treatment." | ( Braverman, DL; Lenrow, DA; Slipman, CW, 2001) |
| "Fibrosis is an unregulated tissue repair process whose predominant characteristics are the proliferation of myofibroblasts and an excessive deposition of extracellular matrix." | ( Klising, E; Lawrence, DA; Martin, MT; Reisdorf, P; Sivan, V, 2001) |
| "Kidney fibrosis is the hallmark of most types of progressive kidney disease, including the genetic disorder Alport's syndrome." | ( Cosgrove, D; Enke, DA; Gotwals, P; Koteliansky, V; Ryan, ST; Sampson, NS, 2001) |
| "When histologic fibrosis is uniformly present through the pancreas in patients with chronic pancreatitis, there is no demarcation of masses due to chronic pancreatitis." | ( Hori, M; Kim, T; Murakami, T; Nakamori, S; Nakamura, H; Sakon, M; Takahashi, S; Takamura, M; Tanji, Y; Wakasa, K, 2001) |
| "The extent of renal fibrosis is the best predictor for functional outcomes in a variety of progressive renal diseases." | ( Ban, S; Inoue, T; Kalluri, R; Kanno, Y; Kobayashi, T; Okada, H; Suzuki, H, 2001) |
| "Tubulointerstitial fibrosis is a crucial process determining the progression and prognosis of various renal diseases." | ( Fujinaga, Y; Makino, H; Mori, K; Mukoyama, M; Nagae, T; Nakao, K; Suganami, T; Sugawara, A; Tanaka, I; Yahata, K; Yokoi, H, 2001) |
| "Tissue fibrosis is the result of a complex series of events focusing on regulation of fibroblast proliferation, synthesis of extracellular matrix, and apoptosis." | ( Kissin, E; Korn, JH, 2002) |
| "Reticulin fibrosis is also commonly associated with systemic mastocytosis." | ( Baek, JY; Li, CY, 2002) |
| "Myocardial fibrosis is common in patients with chronic aortic regurgitation (AR)." | ( Borer, JS; Carter, JN; Dumlao, TF; Falcone, DJ; Herrold, EM; Lee, JA; Pena, M; Supino, PG; Truter, S, 2002) |
| "Fibrosis is one of the major causes of post-treatment morbidity in tuberculosis." | ( Jayasankar, K; Ramanathan, VD; Shakila, H; Umapathy, KC, 2002) |
| "Renal fibrosis is a complication of kidney injury and can contribute to organ failure." | ( Al-Bayati, MA; Giri, SN; Margolin, SB; Mohr, FC; Xie, Y, 2002) |
| "Tubulointerstitial fibrosis is considered to be common endpoint result of many forms of chronic renal diseases." | ( Dai, C; Liu, Y; Yang, J, 2002) |
| "Increasing fibrosis is associated with decreased liver AO levels indicating that severe disease may be a consequence of AO depletion or decreased liver storage resulting from fibrosis." | ( Hertan, HI; Norkus, EP; Pitchumoni, CS; Schweitzer, P; Yadav, D, 2002) |
| "(2) Fibrosis is a common complication of treatment with ergot derivatives." | ( , 2002) |
| "Tubulointerstitial fibrosis is a hallmark feature of chronic renal injury." | ( Kalluri, R; Zeisberg, M, 2003) |
| "Tubulointerstitial fibrosis is tis near invariable finding and significant prognostic feature." | ( Kropiewnicka, E; Niewczas, M; Paczek, L; Pilecki, T; Senatorski, G; Wyzgał, J; Zegarska, J, 2002) |
| "Renal fibrosis is one of the major complications associated with the development of hypertension." | ( Boffa, JJ; Chatziantoniou, C; Dussaule, JC; Lu, Y; Placier, S; Stefanski, A, 2003) |
| "Bladder wall fibrosis is a sequela of recurrent urinary tract infection (UTI)." | ( Austin, PF; Cain, MP; Casale, AJ; Rink, RC; Weintraub, SJ, 2003) |
| "Peritoneal fibrosis is a serious complication in patients on continuous ambulatory peritoneal dialysis (CAPD), but the molecular mechanism of this process remains unclear." | ( Abe, K; Furusu, A; Harada, T; Kohno, S; Koji, T; Mishima, Y; Miyazaki, M; Nishino, T; Ozono, Y, 2003) |
| "Tubulointerstitial fibrosis is a hallmark feature of chronic renal injury." | ( Bottiglio, C; Kalluri, R; Kumar, N; Maeshima, Y; Müller, GA; Strutz, F; Zeisberg, M, 2003) |
| "As inflammation and fibrosis are important components of the progression of chronic renal injury, CLA may be a useful agent in dietary amelioration of renal disease." | ( Aukema, HM; Bankovic-Calic, N; Fitzpatrick-Wong, S; Nitschmann, E; Ogborn, MR; Weiler, HA, 2003) |
| "Myocardial fibrosis is a major component of ventricular remodeling after large myocardial infarction (MI)." | ( Chu, ML; Evangelisti, L; Gao, E; Ma, X; Markova, D; Tsuda, T, 2003) |
| "Tubulointerstitial fibrosis is the final common result of a variety of progressive injuries leading to chronic renal failure." | ( Muragaki, Y; Ooshima, A; Roberts, AB; Saika, S; Sato, M, 2003) |
| "Hepatic fibrosis is due to the increased synthesis and deposition of type I collagen." | ( Mezey, E; Novitskiy, G; Potter, JJ; Rennie-Tankersley, L, 2004) |
| "Radiation-induced fibrosis is an untoward effect of high dose therapeutic and inadvertent exposure to ionizing radiation." | ( Felici, A; Flanders, KC; Fujii, M; Javelaud, D; Mauviel, A; Mitchell, JB; Piek, E; Reiss, M; Roberts, AB; Russo, A; Samuni, AM; Sowers, A; Xavier, S; Yarkoni, S, 2004) |
| "Peritoneal fibrosis is one of the most common morphological changes observed in continuous ambulatory peritoneal dialysis (CAPD) patients." | ( Aguilera, A; Alvarez, V; Aroeira, LS; Bajo, MA; del Peso, G; Gamallo, C; Jiménez-Heffernan, JA; Lara-Pezzi, E; López-Cabrera, M; Ramírez, M; Sánchez-Tomero, JA; Selgas, R, 2004) |
| "However, liver fibrosis is a prolonged change both in gene expression and histopathological alterations." | ( Jiang, Y; Kang, YJ; Liu, J; Waalkes, M, 2004) |
| "Peribronchiolar fibrosis is a prominent feature of airway remodeling in asthma and involves fibroblast growth and collagen deposition." | ( Bonner, JC; Geisenhoffer, K; Ingram, JL; Madtes, DK; Rice, AB, 2004) |
| "Cardiac fibrosis is a key component of heart disease and involves the proliferation and differentiation of matrix-producing fibroblasts." | ( Bathgate, RA; Du, XJ; Layfield, SL; Mak, J; Mookerjee, I; Samuel, CS; Tregear, GW; Unemori, EN, 2004) |
| "Reduced fibrosis is due to deregulated fibroblast function, as the inflammatory response induced by bleomycin was similar in wild-type and Smad3(-/-) mice." | ( Chen, SJ; DiPietro, LA; Ferreira, AM; Han, G; Lakos, G; Masuda, K; Takagawa, S; Varga, J; Wang, XJ, 2004) |
| "Fibrosis is a hallmark of progressive organ diseases." | ( Asano, M; Furuichi, K; Hashimoto, H; Ishiwata, Y; Kitagawa, K; Kuziel, WA; Matsushima, K; Mukaida, N; Takeya, M; Wada, T; Yokoyama, H, 2004) |
| "Ventricular fibrosis is promoted by many effectors that chronically activate phospholipase D (PLD), and induces cardiac dysfunction and heart failure in cardiovascular diseases." | ( Hori, M; Inoue, S; Mano, T; Masuyama, T; Miwa, T; Nishikawa, N; Oishi, Y; Sakata, Y; Takahashi, Y; Yamamoto, K; Yoshida, J, 2004) |
| "Fibrosis is characterized by an excessive accumulation of collagen which contains increased levels of pyridinoline cross-links." | ( Bank, RA; Boers, W; DeGroot, J; Huizinga, TW; Karel Ronday, H; Middelkoop, E; Ulrich, MM; van den Bogaerdt, AJ; van der Slot, AJ; Zuurmond, AM, 2004) |
| "Fibrosis is a characteristic feature in the pathogenesis of a wide spectrum of diseases." | ( Cheever, AW; Davies, SJ; Hesse, M; Kaviratne, M; Letterio, JJ; Leusink, M; McKerrow, JH; Wakefield, LM; Wynn, TA, 2004) |
| "In such conditions, fibrosis is mediated, at least partially, through ANG II induction of the cytokine transforming growth factor-beta1 (TGF-beta1)." | ( Faitelson, Y; Goldin, E; Latella, G; Pappo, O; Pines, M; Sestieri, M; Villanova, A; Wengrower, D; Zannineli, G; Zanninelli, G, 2004) |
| "Significant fibrosis is frequent, and its progression is mostly influenced by iron overload which, with current therapy regimens, may be attributable to both erythrocyte catabolism and iron hyperabsorption." | ( Cappellini, MD; Cerino, M; Cianciulli, P; Coggi, G; Fiorelli, G; Forni, GL; Gramignoli, R; Maggioni, M; Magnano, C; Meo, A; Milani, S; Prati, D; Rebulla, P, 2004) |
| "Because cutaneous fibrosis is the hallmark of scleroderma, we also studied dermal fibroblasts." | ( Bonner, M; Gooz, P; Hacker, S; Hoffman, S; Pannu, J; Scholz, D; Silver, RM; Tourkina, E; Trojanowska, M, 2005) |
| "Pancreatic fibrosis is a characteristic feature of chronic pancreatic injury, which is a result of the imbalance between synthesis and degradation of extracellular matrix (ECM) proteins." | ( Cho, SW; Choi, JH; Hahm, KB; Kim, JH; Kim, SJ; Kim, WW; Oh, TY; Yeo, M; Yoo, BM, 2005) |
| "Renal fibrosis is an evolutive process frequently leading to end stage renal failure." | ( Martin, PY; Niksic, L, 2005) |
| "The hallmark of fibrosis is the excessive accumulation of collagen." | ( Bank, RA; De Groot, J; de Wit, EC; Huizinga, TW; van der Slot, AJ; van Dura, EA; Zuurmond, AM, 2005) |
| "Tubulointerstitial fibrosis is a relatively common and sinister complication of cyclosporine A (CsA) therapy that limits its clinical use." | ( Campbell, E; Gaffney, MM; McMorrow, T; Ryan, MP; Slattery, C, 2005) |
| "Tissue fibrosis is one of the characteristics of chronic pancreatitis and pancreatic adenocarcinoma." | ( Chen, Y; Fürst, D; Jesnowski, R; Kleeff, J; Kolb, A; Löhr, M; Ringel, J; Schareck, WD; Schrödel, A, 2005) |
| "Interstitial fibrosis is the main characteristic of chronic allograft nephropathy and long-term graft failure." | ( Bajema, IM; Bemelman, F; de Fijter, JW; Eikmans, M; Florquin, S; Idu, M; Mallat, MJ; Paul, LC; Roos-van Groningen, MC; Rowshani, AT; Scholten, EM; Surachno, JS; ten Berge, I; van Groningen, MC, 2006) |
| "Tubulointerstitial fibrosis is the consequence of an injury characterized by the accumulation of excess collagen and other extracellular matrix components, resulting in the destruction of the normal kidney architecture and subsequent loss of function." | ( Chae, YM; Chang, YC; Kim, CH; Kim, JK; Lee, IK; Park, KK, 2006) |
| "Tubulointerstitial fibrosis is a common feature of many progressive renal diseases and is a main determinant that leads to an irreversible loss of renal function." | ( Asai, T; Iwai, T; Kaneda, N; Komiya, T; Kuwabara, N; Miura, K; Nakatani, T; Tamada, S; Teramoto, K; Uchida, J; Yukimura, T, 2006) |
| "Renal fibrosis is the inevitable consequence of an excessive accumulation of extracellular matrix that occurs in virtually every type of chronic kidney disease." | ( Liu, Y, 2006) |
| "Increased medullary fibrosis is correlated with chronic cortical damage." | ( Camsari, T; Celik, A; Gulay, H; Kasap, B; Kavukcu, S; Sarioglu, S; Sis, B; Yildiz, S, 2006) |
| "Interstitial fibrosis is a characteristic pathological feature of HCM and a risk factor for sudden cardiac death." | ( Chen, SN; Lombardi, R; Marian, AJ; Senthil, V, 2006) |
| "Fibrosis is a common pathological feature observed in muscle from patients with Duchenne muscular dystrophy and in mdx diaphragm." | ( Gosselin, LE; Williams, JE, 2006) |
| "Hepatic fibrosis is a common outcome of a variety of chronic liver diseases." | ( Dai, C; Liu, Y; Michalopoulos, GK; Xia, JL, 2006) |
| "Scar and fibrosis are often the end result of mechanical injury and inflammatory diseases." | ( DiPietro, LA; Ferreira, AM; Fresco, R; Takagawa, S; Varga, J; Zhu, X, 2006) |
| "Subepithelial fibrosis is a cardinal feature of bronchial asthma." | ( Arima, K; Hotokebuchi, T; Izuhara, K; Kanaji, T; McKenzie, AN; Nagai, H; Shoji, S; Takayama, G; Tanaka, H; Toda, S, 2006) |
| "Pleural fibrosis is a double-edged sword in clinical settings." | ( Kalomenidis, I; Lee, YC; Mutsaers, SE; Wilson, NA, 2006) |
| "Fibrosis is a major cause of human death and disability." | ( Karasek, MA, 2007) |
| "Excessive fibrosis is frequently associated with endometriosis." | ( Matsumoto, H; Narahara, H; Nasu, K; Nishida, M; Yuge, A, 2007) |
| "Fibrosis is characterized by the persistence of activated myofibroblasts, ineffective re-epithelialization, and variable degrees of inflammation within injured tissues." | ( Han, MK; Horowitz, JC; Moore, BB; Thannickal, VJ; Vittal, R; Zhang, H, 2007) |
| "Tubulointerstitial fibrosis is a final common pathway to the eventual structural desolation of kidneys." | ( Chen, J; Li, J; Li, Y; Liu, FY; Peng, YM, 2007) |
| "Hepatic fibrosis is a dynamic process that involves the interplay of different cell types in the hepatic tissue." | ( George, J; Tsutsumi, M, 2007) |
| "Obstruction-induced fibrosis is a leading cause of end-stage renal failure in children." | ( Eskild-Jensen, A; Frøkiaer, J; Nyengaard, JR; Olesen, P; Paulsen, LF; Pedersen, L; Wogensen, L, 2007) |
| "Interstitial fibrosis is a universal feature of progressive kidney disease." | ( Cai, X; Collins, SJ; Eddy, AA; Lopez-Guisa, JM; Okamura, DM; Yamaguchi, I, 2007) |
| "Renal fibrosis is a hallmark of end-stage renal diseases and of chronic allograft nephropathy (CAN)." | ( Bertocchi, AP; Câmara, NO; Cenedeze, MA; Damião, MJ; Dos Reis, MA; Feitoza, CQ; Giannocco, G; Gonçalves, GM; Marques, GD; Mazzali, M; Monteiro, RM; Pacheco-Silva, A; Teixeira, VP, 2007) |
| "EMT in tissue fibrosis is a form of reverse embryogenesis, when highly specialized epithelial cells in the specific organs will respond to injury with loosing their epithelial characteristics and functions and regaining characteristics of the cells from which they originated." | ( Mucsi, I; Rosivall, L, 2007) |
| "Progressive fibrosis is a cause of progressive organ dysfunction." | ( Kopp, JB; Lucio-Cazana, J; Norman, JT; Shrivastav, S; Xu, Q, 2007) |
| "Fibrosis is a common side effect after treatment with ionizing radiation." | ( Altemus, RM; Augustine, E; Camphausen, KA; Gerber, L; Mitchell, JB; Simone, NL; Smith, S; Soule, BP, 2007) |
| "Progressive renal fibrosis is an unwanted and limiting side effect of cancer treatments, whether they are systemic (for example, chemotherapy), local (for example, radiotherapy), or total body irradiation for allogenic bone marrow transplants." | ( Gobe, GC; Johnson, DW; Vesey, DA; Wei, MQ; Yang, T, 2007) |
| "Skin fibrosis is a hallmark of ionizing radiation-induced tissue injury and we hypothesized that mast cells via their products (especially tryptase) are involved in this event." | ( Albrecht, M; Köhn, FM; Mayerhofer, A; Meineke, V; Müller, K, 2007) |
| "Tissue fibrosis is a hallmark compromising feature of many disorders." | ( Distler, JH; Distler, O; Gay, RE; Gay, S; Hauser, T; Hemmatazad, H; Huber, LC; Jüngel, A; Matucci-Cerinic, M; Michel, BA; Moritz, F, 2007) |
| "Fibrosis is a hallmark of progressive organ disease." | ( Furuichi, K; Gerard, C; Haino, M; Ishida, Y; Kaneko, S; Kawachi, H; Kitagawa, K; Kondo, T; Matsushima, K; Nakaya, I; Narumi, S; Sakai, N; Shimizu, F; Sugaya, T; Wada, T; Yokoyama, H, 2007) |
| "Fibrosis is excessive scarring caused by the accumulation of extracellular matrix proteins and is a common end pathway in many chronic diseases." | ( Abraham, DJ; Black, CM; Bou-Gharios, G; Chen, Y; Dashwood, MR; Denton, CP; du Bois, RM; Howat, S; Kennedy, L; Leask, A; Pearson, JD; Renzoni, EA; Shi-Wen, X, 2007) |
| "Reversal of cardiac fibrosis is a major determinant of the salutary effects of mineralocorticoid receptor antagonists in heart failure." | ( Beugels, IP; Cohuet, GM; de Gooyer, ME; Emmen, JM; Hermans, JJ; Hilbers, PA; Minnaard-Huiban, M; Ottenheijm, HC; Pieterse, K; Plate, R; Roumen, L; Ruijters, E; Smits, JF; van Essen, H, 2008) |
| "Fibrosis is a major complication of chronic inflammation, as seen in Crohn's disease and ulcerative colitis, two forms of inflammatory bowel diseases." | ( Chakravarti, S; Wu, F, 2007) |
| "Tubulointerstitial fibrosis is a hallmark of chronic progressive kidney disease leading to end-stage renal failure." | ( Choi, ME; He, Y; Kim, SI; Kwak, JH; Lee, JY; Wang, L, 2008) |
| "Fibrosis is defined by the overgrowth, hardening, and/or scarring of various tissues and is attributed to excess deposition of extracellular matrix components including collagen." | ( Wynn, TA, 2008) |
| "Pulmonary fibrosis is characterized by alterations in fibroblast phenotypes resulting in excessive extracellular matrix accumulation and anatomic remodeling." | ( Gangireddy, SR; Hogaboam, CM; Hu, B; Keshamouni, VG; Milam, JE; Phan, SH; Reddy, RC; Standiford, TJ; Thannickal, VJ, 2008) |
| "Peridural fibrosis is one of the more frequent complications of lumbar surgery." | ( Hernandez-Vaquero, D; Sandoval, MA, 2008) |
| "Arthrofibrosis is a disabling complication after knee trauma and surgery and is characterised clinically by joint stiffness." | ( Bosch, U; Brand, J; Haeder, L; Jagodzinski, M; Lobenhoffer, P; Zeichen, J, 2008) |
| "Renal fibrosis is the major determinant in progression of kidney disease and results from an inappropriate response to acute and chronic kidney injury." | ( Goldschmeding, R; Nguyen, TQ, 2008) |
| "Peritoneal fibrosis is a major complication leading to the loss of peritoneal function in patients undergoing peritoneal dialysis." | ( Asanuma, M; Fukuoka, N; Inoue, T; Kikumoto, Y; Maeshima, Y; Makino, H; Masuoka, N; Morinaga, H; Nakao, K; Ogino, K; Sugiyama, H; Takiue, K; Wang, DH, 2008) |
| "Quantification of fibrosis is a key parameter in the assessment of the severity of cardiovascular disease and efficacy of future candidate therapies." | ( Gaspard, GJ; Pasumarthi, KB, 2008) |
| "Skeletal muscle fibrosis is a major pathological hallmark of chronic myopathies in which myofibers are replaced by progressive deposition of collagen and other extracellular matrix proteins produced by muscle fibroblasts." | ( Kollias, HD; Li, ZB; Wagner, KR, 2008) |
| "Cardiac fibrosis is an important component of diabetic cardiomyopathy." | ( Caglayan, E; Collins, AR; Erdmann, E; Hsueh, WA; Liu, J; Lyon, CJ; Peterson, LE; Rosenkranz, S; Ross, RS; Stauber, B; Tangirala, RK; Yin, F, 2008) |
| "Peritoneal fibrosis is a serious complication in long-term peritoneal dialysis (PD) patients." | ( Chen, W; Dong, X; Liu, Q; Mao, H; Nie, J; Yang, Q; Yu, X, 2008) |
| "Renal fibrosis is highly implicated as a cause of chronic renal failure, for which suitable therapeutics have not yet been developed." | ( Boo, YC; Kim, J; Park, KM; Park, MJ; Park, YK; Seok, YM, 2008) |
| "Tubulointerstitial fibrosis is a final common pathway to end-stage chronic kidney diseases, which are characterized by elevated renal angiotensin II (AngII) production." | ( Carvajal-González, G; Egido, J; Mezzano, S; Ortiz, A; Rodrigues Díez, R; Rodrigues-Díez, R; Rodríguez-Vita, J; Ruiz-Ortega, M; Sánchez-López, E; Selgas, R, 2008) |
| "Fibrosis is an important component of large conduit artery disease in hypertension." | ( Carretero, OA; D'Ambrosio, MA; Liao, TD; Lin, CX; Rhaleb, NE; Yang, XP, 2008) |
| "Fibrosis is a known feature of dystrophic muscles, particularly the diaphragm, in the mdx mouse." | ( Anderson, JE; Genin, O; Hagai, Y; Halevy, O; Huebner, K; Jassal, DS; Nagler, A; Pines, M; Turgeman, T, 2008) |
| "Fibrosis is a common feature of chronic kidney diseases that is mediated by matrix-producing myofibroblasts." | ( Daniel, C, 2008) |
| "Tissue fibrosis is a major cause of death in SSc, but therapies that target selectively fibrosis are not yet available for routine clinical use." | ( Distler, JH; Distler, O, 2008) |
| "Fibrosis is a hallmark of renal damage in several diseases, including arterial hypertension." | ( Belloni, AS; Guidolin, D; Maniero, C; Pessina, AC; Pothen, P; Rossi, GP; Seccia, TM, 2008) |
| "Diffuse myocardial fibrosis is a fundamental process in pathologic remodeling in cardiomyopathy and is postulated to cause increased cardiac stiffness and poor clinical outcomes." | ( Aksit, P; Cherayath, J; Gupta, SN; Iles, L; Kaye, DM; Pfluger, H; Phrommintikul, A; Taylor, AJ, 2008) |
| "Pancreatic fibrosis is the hallmark of chronic pancreatitis, currently an incurable disease." | ( Chen, Y; He, J; Liu, X; Qian, KQ; Sun, X; Wang, Z, 2009) |
| "Myocardial fibrosis is the major determinant of diastolic property of the left ventricle (LV)." | ( Imaizumi, T; Kai, H; Kuwahara, F; Mizoguchi, M; Mizuta, Y; Nakaura, H; Osada, K; Tahara, N, 2008) |
| "Myocardial fibrosis is an integral component of most cardiac pathologic conditions and contributes to the development of both systolic and diastolic dysfunction." | ( Corbett, D; Frangogiannis, NG; Lee, K; Li, N; Mendoza, L; Xia, Y, 2009) |
| "Fibrosis is the result of the unbalance between exaggerated collagen synthesis and unchanged or depressed collagen degradation." | ( Díez, J; González, A; Hermida, N; Laviades, C; López, B, 2008) |
| "Renal fibrosis is characterized by excessive accumulation of extracellular matrix proteins." | ( Aicher, WK; Alexander, D; Artunc, F; Friedrich, B; Janessa, A; Lang, F; Müller, GA; Risler, T, 2008) |
| "Fibrosis is a major cause of end-stage renal disease, and although initiation factors have been elucidated, uncertainty concerning the downstream pathways has hampered the development of anti-fibrotic therapies." | ( Najmabadi, F; Perbal, B; Peterson, DR; Rambow, JA; Riser, BL; Riser, ML; Riser, SC; Sukowski, E; Yeger, H, 2009) |
| "Peritoneal fibrosis is a serious complication of peritoneal dialysis (PD)." | ( Arakawa, T; Doi, S; Ito, T; Kawai, T; Kohno, N; Masaki, T; Nakashima, A; Takahashi, S; Taniguchi, Y; Yorioka, N, 2009) |
| "Cardiac fibrosis is a hallmark of cardiovascular remodeling associated with hypertension." | ( Asada, Y; Hatakeyama, K; Imamura, T; Kato, J; Kitamura, K; Masuyama, H; Sekita, Y; Stasch, JP; Tsuruda, T, 2009) |
| "Fibrosis is a scarring process that is a common feature of chronic organ injury." | ( Borkham-Kamphorst, E; Gressner, AM; Gressner, OA; Herrmann, J; Meurer, SK; Weiskirchen, R, 2009) |
| "Myocardial fibrosis is a hallmark of inflammation-triggered end-stage heart disease, a common cause of heart failure in young patients." | ( Blyszczuk, P; Dirnhofer, S; Eriksson, U; Germano, D; Hunziker, L; Kania, G; Matter, CM; Stein, S; Valaperti, A, 2009) |
| "Myocardial fibrosis is the major factor that regulates left ventricular (LV) diastolic function." | ( Aoki, I; Goto, T; Ito, H; Katsuta, M; Terui, G, 2009) |
| "Peridural fibrosis is a common cause of pain in patients undergoing spinal surgery." | ( Celik, B; Cemil, B; Ceviker, N; Durdag, E; Erdem, O; Kurt, G, 2009) |
| "Fibrosis is the response of heart and other organs to injuries." | ( Tang, J; Wang, DW; Wang, P; Xiao, X; Yan, W; Zhao, CX, 2009) |
| "The mechanism of fibrosis is not clear in patients with obliterative bronchiolitis after a remote injury." | ( Fuehrer, NE; Jagirdar, J; Marchevsky, AM, 2009) |
| "The LV fibrosis is often found in the IVS with DCM." | ( Harada, M; Inoue, Y; Nakano, H; Namiki, A; Nanjo, S; Yamazaki, J; Yoshikawa, K, 2009) |
| "Vascular fibrosis is a major complication of hypertension and atherosclerosis, yet it is largely untreatable." | ( Arany, ZP; Hofmann, F; Itoh, H; Miyashita, K; Nakao, K; Sawada, N; Sone, M; Tsujimoto, H; Yamahara, K, 2009) |
| "Renal interstitial fibrosis is a major determinant of renal failure in the majority of chronic renal diseases." | ( Hirschberg, R; Leof, EB; Wang, S; Wilkes, MC, 2010) |
| "Tissue fibrosis is a major cause of morbidity and mortality in systemic sclerosis (SSc), and an increasing number of promising molecular targets for antifibrotic therapies have been described recently." | ( Fujimoto, M; Hasegawa, M; Higashi, K; Horikawa, M; Kaneko, H; Matsushita, Y; Sato, S; Shirasaki, F; Takehara, K; Tomigahara, Y, 2009) |
| "Fibrosis is a common end point of many pathological processes affecting the myocardium and may alter myocardial relaxation properties." | ( Ambrosio, G; De Chiara, B; Mauri, F; Moreo, A; Pu, M; Raman, SV; Tran, T, 2009) |
| "Epidural fibrosis is the scar tissue formed over the dura mater after a laminectomy." | ( Cemil, B; Cevirgen, B; Comert, A; Kaptanoglu, E; Kaymaz, F; Tekdemir, I; Tun, K, 2009) |
| "Since fibrosis is observed in smokers' gingiva, it was hypothesized that fibrosis was caused by nicotine in the periodontium." | ( Endo, K; Kubota, S; Murakashi, E; Ng, PS; Numabe, Y; Takeuchi, H; Takigawa, M; Zhou, Y, 2010) |
| "Renal fibrosis is the final common pathway of chronic kidney disease, and its progression predicts the degree of renal dysfunction." | ( Chikanishi, T; Fujimori, A; Itoh, H; Iwatsuki, Y; Nakajima, H; Okada, M; Takakuta, K; Tanokura, A; Yamamoto, M, 2010) |
| "Tubulointerstitial fibrosis is characterized by the presence of myofibroblasts that contribute to extracellular matrix accumulation." | ( Arévalo, M; Fuentes-Calvo, I; Grande, MT; Heredia, F; López-Novoa, JM; Martínez-Salgado, C; Nieto, MA; Rodríguez-Puyol, D; Santos, E, 2010) |
| "Fibrosis is a hallmark of arrhythmogenic structural remodeling, but the underlying molecular mechanisms are incompletely understood." | ( Adam, O; Ameling, S; Böhm, M; Grube, M; Hohl, M; Kroemer, HK; Laufs, U; Lavall, D; Rosenkranz, S; Schäfers, HJ; Sussman, MA; Theobald, K, 2010) |
| "Intestinal fibrosis is a major complication of Crohn disease (CD), but the precise mechanism by which it occurs is incompletely understood." | ( Flier, SN; Kalluri, R; Kokkotou, EG; Sugimoto, H; Tanjore, H; Zeisberg, M, 2010) |
| "Cardiac fibrosis is a consequence of many cardiovascular diseases and contributes to impaired ventricular function." | ( Chan, EC; Dilley, R; Dusting, GJ; Guo, N; Jiang, F; Narumiya, S; Peshavariya, HM; Taylor, CJ, 2010) |
| "Fibrosis is a fundamental component of the adverse structural remodeling of myocardium present in the failing heart." | ( Ahokas, RA; Bhattacharya, SK; Gandhi, MS; Gerling, IC; Kamalov, G; Shahbaz, AU; Sun, Y; Weber, KT, 2011) |
| "Fibrosis is a frequent complication of diabetes mellitus in many organs and tissues but the mechanism of how diabetes-induced glycation of extracellular matrix proteins impacts the formation of fibrotic lesions is not defined." | ( Birek, J; Chan, M; Laschinger, C; Lee, W; McCulloch, CA; Simmons, CA; Sivagurunathan, K; Talior, I; Won, E; Young, EW; Yuen, A, 2010) |
| "Epidural fibrosis is a well-known complication following lumbar disc surgery." | ( Altinors, N; Calisaneller, T; Caner, H; Kiyici, H; Ozdemir, O; Sonmez, E, 2010) |
| "Skeletal muscle fibrosis is present in the diaphragm of the mdx mouse, a model for Duchenne dystrophy." | ( Bruemmer, K; Carlson, CG; Curtis, H; Gatti, F; Graham, KM; Malnassy, G; Millman, G; Sesti, J; Singh, R; Stefanski, C, 2010) |
| "Myocardial fibrosis is frequently identified in patients with hypertrophic cardiomyopathy (HCM)." | ( Borggrefe, M; Doesch, C; Fluechter, S; Germans, T; Haghi, D; Kuschyk, J; Papavassiliu, T; Schoenberg, SO; Streitner, F; Sueselbeck, T; Veltmann, C; Wolpert, C, 2010) |
| "Oral submucous fibrosis is a common premalignant condition caused by chewing arecanut and other irritants in various forms." | ( Gupta, SC; Mehrotra, R; Niranjan, HS; Sharma, D; Singh, M, 2010) |
| "Fibrosis is one of the largest groups of diseases for which there is no therapy but is believed to occur because of a persistent tissue repair program." | ( Leask, A, 2010) |
| "Capsular fibrosis is one of the most severe complications that can occur in connection with silicone breast implants." | ( Larena-Avellaneda, A; Schmidt, K; Zeplin, PH, 2010) |
| "Fibrosis is the final common pathway for various tissue lesions that lead to chronic progressive organ failure, and consequently effective antifibrotic drugs are strongly desired." | ( Kato, M; Mizuno, M; Sada, T; Terashima, H; Tsuchida, H; Yasumo, H, 2010) |
| "Fibrosis is a newly appreciated hallmark of the pathological alteration of human white adipose tissue (WAT)." | ( Aissat, A; Basdevant, A; Bedossa, P; Clément, K; Divoux, A; Guerre-Millo, M; Hugol, D; Lacasa, D; Poitou, C; Tordjman, J; Veyrie, N; Zucker, JD, 2010) |
| "Tissue fibrosis is believed to be a manifestation of dysregulated repair following injury, in association with impaired reepithelialization, and aberrant myofibroblast activation and proliferation." | ( Aesif, SW; Anathy, V; Budd, RC; Guala, AS; Janssen-Heininger, YM; Reiss, JN; Reynaert, NL; Roberson, EC; van der Velden, J, 2010) |
| "Diffuse fibrosis is a likely common final pathway and is quantifiable using MRI." | ( Broberg, CS; Chugh, SS; Conklin, C; Jerosch-Herold, M; Sahn, DJ, 2010) |
| "Fibrosis is the end point of most renal diseases, and several glycosaminoglycans have been shown to attenuate this process." | ( Belmiro, CL; Gonçalves, RG; Leite, M; Melo-Filho, NM; Mourão, PA; Pavão, MS; Takiya, CM, 2010) |
| "Fibrosis is due not only to the activation of tissue-resident fibroblasts and their transdifferentiation into myofibroblasts, but also the differentiation of bone marrow-derived fibrocytes, and transition of endothelial and epithelial cells, pericytes and adipocytes into activated mesenchymal cells." | ( Bhattacharyya, S; Tourtellotte, WG; Varga, J; Wei, J, 2011) |
| "Altogether, fibrosis is associated with an increased risk of ventricular dysfunction and arrhythmias." | ( Creemers, EE; Pinto, YM, 2011) |
| "fibrosis is associated with various cardiac pathologies and dysfunction." | ( Beliën, JA; Grunberg, K; Hadi, AM; Meijer, GA; Mouchaers, KT; Schalij, I; van der Laarse, WJ; Vonk-Noordegraaf, A, 2010) |
| "Renal interstitial fibrosis is the major histopathological change seen in a variety of renal disorders and is closely related to renal dysfunction." | ( Deng, Y; Fan, JM; Liu, HC; Wang, FP; Xie, XS; Zhang, CL; Zuo, C, 2010) |
| "Tubulointerstitial fibrosis is a common outcome of several progressive renal diseases." | ( Hayashi, T; Inoue, T; Ishizaka, N; Kitada, K; Kitaura, Y; Kurumazuka, D; Matsuda, H; Matsumura, Y; Mori, T; Nagatoya, K; Ukimura, A, 2011) |
| "Fibrosis is a pathological feature observed in patients with Duchenne muscular dystrophy (DMD) and in mdx mice, the experimental model of DMD." | ( Marques, MJ; Matsumura, CY; Pertille, A; Santo Neto, H; Taniguti, AP, 2011) |
| "Interstitial fibrosis is an outcome measure of increasing importance in clinical trials of both renal transplantation and native disease, but data on the comparative advantages of fibrosis measurement methods are limited." | ( Adams, CD; Brousaides, N; Collins, AB; Colvin, RB; Della Pelle, PA; Farris, AB; Grimm, PC; Moradi, E; Smith, RN, 2011) |
| "Myocardial fibrosis is characterized by significant extracellular matrix (ECM) deposition." | ( Lee, TD; Légaré, JF; Rosin, NL; Sopel, MJ, 2011) |
| "Myocardial fibrosis is related to clinical disease severity and LV systolic dysfunction in isolated LVNC." | ( Aquaro, GD; Lombardi, M; Masci, PG; Nucifora, G; Pingitore, A, 2011) |
| "SSCT fibrosis is present for up to 12 weeks after dextrose injection; multiple injections have bigger effects, including what appears to be a secondary change in nerve flattening." | ( Amadio, PC; An, KN; Low, PA; Schmelzer, JD; Yoshii, Y; Zhao, C, 2011) |
| "Hepatic fibrosis is the result of chronic liver injuries underlined by diverse etiologies." | ( Ding, Z; Ke, Z; Kng, Y; Yang, H; Zhuo, L, 2011) |
| "Myocardial fibrosis is the common results of the development of a variety of heart diseases which leads to extracellular matrix protein metabolic disorders and causes cardiac remodeling owing to cardiac fibroblasts proliferation, eventually results in malignant arrhythmia, heart failure, and even the occurrence of sudden cardiac death." | ( Wang, LY; Yang, SJ, 2010) |
| "The presence of fibrosis is associated with alterations in organ architecture and is responsible for the morbidity of diseases including pneumopathies, systemic sclerosis, liver cirrhosis, chronic cardiovascular diseases, progressive kidney diseases and diabetes." | ( Bascands, JL; Gonzalez, J; Klein, J; Pradère, JP; Rancoule, C; Saulnier-Blache, JS; Schanstra, JP; Valet, P, 2011) |
| "Fibrosis is a deregulated and ultimately defective form of tissue repair that underlies a large number of chronic human diseases, as well as obesity and aging." | ( Bhattacharyya, S; Fang, F; Feghali-Bostwick, C; Tourtellotte, W; Varga, J; Wu, M, 2011) |
| "Fibrosis is associated with various cardiac pathologies and dysfunction." | ( Beliën, JA; Grunberg, K; Hadi, AM; Meijer, GA; Mouchaers, KT; Schalij, I; van der Laarse, WJ; Vonk-Noordegraaf, A, 2011) |
| "Organ fibrosis is associated with excessive deposition of dermatan sulfate (DS) in the extracellular matrix (ECM) of the affected tissue." | ( Koźma, EM; Kusz, D; Olczyk, K; Wisowski, G, 2011) |
| "Myocardial fibrosis is a key pathological feature of HFPEF." | ( Anand, IS; Black, M; Carson, PE; Elsik, M; Komajda, M; Krum, H; Massie, BM; McKelvie, RS; McMurray, JJ; Ptaszynska, A; Schneider, HG; Zile, MR, 2011) |
| "Renal interstitial fibrosis is a common outcome of a variety of chronic renal diseases." | ( He, D; Lee, L; Wang, X; Yang, J, 2011) |
| "Significant atrial fibrosis is associated with clinically significant SND requiring pacemaker implantation." | ( Akoum, N; Badger, T; Kholmovski, E; Macleod, R; Mahnkopf, C; Marrouche, N; McGann, C; Ranjan, R; Vergara, G, 2012) |
| "Thus, renal fibrosis is characterized by a reduction of PPAR-α expression, and treatment with BAY PP1 restores PPAR-α expression and ameliorates renal fibrosis by modulating the cross-talk between tubular cells and fibroblasts." | ( Albrecht-Küpper, B; Boor, P; Celec, P; Esposito, C; Heidland, A; Hodosy, J; Klenovicsová, K; Martin, IV; Ostendorf, T; Schäfer, S; Šebeková, K; Villa, L, 2011) |
| "Renal fibrosis is mediated by the accumulation of myofibroblasts, whereas renal anemia is mediated by the reduced production of fibroblast-derived erythropoietin, a hormone that stimulates erythropoiesis." | ( Asada, M; Asada, N; Fehling, HJ; Fukatsu, A; Kimura, T; Kita, T; Minegishi, N; Nagoshi, N; Nakamura, J; Oguchi, A; Okano, H; Rao, TN; Shibata, S; Suzuki, N; Takase, M; Yamamoto, M; Yamamura, K; Yanagita, M, 2011) |
| "Anthracofibrosis is a bronchial stenosis due to local mucosal fibrosis that also presents anthracotic pigment in the mucosa." | ( Fernández-Navamuel, I; Gómez-Seco, J; Guerrero-González, J; Pérez-Boal, I; Rodríguez-Nieto, MJ; Sáez-Noguero, F, 2012) |
| "Myocardial fibrosis is an important contributor to heterogeneity of left ventricular (LV) dysfunction in the metabolic syndrome (MS)." | ( Kosmala, W; Marwick, TH; Mysiak, A; Przewlocka-Kosmala, M; Wojnalowicz, A, 2012) |
| "Intestinal fibrosis is a challenging clinical condition in several fibrostenosing enteropathies, particularly Crohn's disease." | ( Goldin, E; Israeli, E; Latella, G; Lysy, J; Metanes, I; Necozione, S; Papo, O; Pines, M; Wengrower, D; Zanninelli, G, 2012) |
| "Renal interstitial fibrosis is the common pathway in progressive renal diseases, where oxidative stress promotes inflammation and macrophage infiltration." | ( Inoue, K; Isaka, Y; Kaimori, J; Kawada, N; Matsui, I; Moriyama, T; Omori, H; Rakugi, H; Takabatake, Y; Ueda, Y; Yamamoto, R, 2012) |
| "Kidney fibrosis is a common process that leads to the progression of various types of kidney disease." | ( Chen, EY; Chen, N; Chuang, PY; D'Agati, V; Dai, Y; Fan, Y; He, JC; Jin, Y; Ma'ayan, A; Mazloom, AR; Ratnam, K; Ross, MJ; Xiong, H; Zhong, Y, 2012) |
| "Fibrosis is a key feature of systemic sclerosis (SSc) and arises from excessive release of collagens by pathologically activated fibroblasts." | ( Beyer, C; Distler, JH; Distler, O, 2012) |
| "Interstitial fibrosis is an inevitable outcome of all kinds of progressive chronic kidney disease (CKD)." | ( Chen, G; Chen, H; Liu, F; Liu, H; Peng, Y; Sun, L; Wang, C, 2012) |
| "Fibrosis is the predominant chemotherapy-related pathologic alteration driving the association of treatment response with survival after CLM resection." | ( Allen, PJ; Bao, F; D'Angelica, MI; DeMatteo, RP; Fong, Y; Hernandez-Boussard, T; Jarnagin, WR; Kemeny, NE; Klimstra, DS; Poultsides, GA; Saltz, LB; Servais, EL; Shia, J, 2012) |
| "Liver fibrosis is a reversible pathology characterized by the up-regulated secretion and deposition of ECM proteins and inhibitors of metalloproteinases, which increase the stiffness and viscosity of this organ." | ( Bader, A; Díaz-Cuenca, A; Fritsch, A; Heidebrecht, F; Käs, J; Leal-Egaña, A; Nowicki, M, 2012) |
| "Intestinal fibrosis is one of the major complications of Crohn's disease (CD) for which there are no effective pharmacological therapies." | ( Higgins, PD; Johnson, LA; Rodansky, ES; Sauder, KL; Simpson, RU, 2012) |
| "Peridural fibrosis is an inevitable healing process causing failed back surgery syndrome after lumbar spinal operations." | ( Akbasak, A; Erdogan, H; Huseyinoglu, U; Kaya, M; Kosemehmetoglu, K; Tasdemiroglu, E; Yildirim, CH, 2012) |
| "Renal fibrosis is a common finding in progressive renal diseases." | ( Akimoto, T; Arai, T; Du, X; Fukuda, Y; Iino, Y; Kaneko, T; Kataoka, M; Kuwahara, N; Masuda, Y; Shimizu, A; Uchiyama, M, 2012) |
| "Progressive renal fibrosis is the final common pathway leading to renal failure irrespective of the initiating cause." | ( Dewage, L; Gan, PY; Holdsworth, SR; Kitching, AR; Ma, FT; Nikolic-Paterson, DJ; O'Sullivan, KM; Ooi, JD; Summers, SA, 2012) |
| "Fibrosis is a pathological process characterized by massive deposition of extracellular matrix (ECM) such as type I/III collagens and fibronectin that are secreted by an expanded pool of myofibroblasts, which are phenotypically altered fibroblasts with more contractile, proliferative, migratory and secretory activities." | ( Ikeda, H; Okamoto, Y; Takuwa, N; Takuwa, Y; Yoshioka, K, 2013) |
| "Atrial fibrosis is important for the pathogenesis of atrial fibrillation (AF) but the underlying signal transduction is incompletely understood." | ( Adam, O; Böhm, M; Gupta, SK; Laufs, U; Löhfelm, B; Puhl, SL; Schäfers, HJ; Thum, T, 2012) |
| "Cardiac fibrosis is a hallmark of heart disease and plays a vital role in cardiac remodeling during heart diseases, including hypertensive heart disease." | ( Cao, JM; Chen, C; Ding, F; Gao, X; Hao, W; Pang, J; Xu, RK; Xu, X, 2012) |
| "Fibrosis is one of the major pathological features of hypertensive vascular disease." | ( Deng, S; Huang, D; Huang, K; Wang, L; Wang, R; Wang, Y; Zhang, C; Zhang, F; Zhang, Y, 2013) |
| "Intestinal fibrosis is a major complication of Crohn's disease." | ( Blue, RE; Ding, S; Lund, PK; Macnaughton, K; Magness, ST; McNaughton, K; Walton, KL, 2012) |
| "Interstitial fibrosis is regarded as the common final pathway in chronic renal failure." | ( Ichikawa, C; Izawa, T; Juniantito, V; Kuwamura, M; Yamate, J; Yano, R; Yuasa, T, 2013) |
| "Tissue fibrosis is the prominent reason for mortality, and still, there is no satisfactory treatment." | ( Bagcı, C; Demir, T; Kaplan, DS; Kisacik, B; Onat, AM; Orkmez, M; Pehlivan, Y; Taysi, S; Turkbeyler, I; Tutar, E, 2013) |
| "Fibrosis is a result of chronic irritation by various factors and is defined by an excess production of extracellular matrix leading to tissue scarring and organ dysfunction." | ( Huwiler, A; Pfeilschifter, J; Schwalm, S, 2013) |
| "Tissue fibrosis is a major hallmark and a leading cause of death in systemic sclerosis (SSc)." | ( Beyer, C; Cedzik, D; Dees, C; Distler, A; Distler, JH; Distler, O; Palumbo-Zerr, K; Schafer, PH; Schett, G; Shankar, SL; Tomcik, M; Weingärtner, S; Zerr, P, 2012) |
| "Fibrosis is a predominant cause of death in systemic sclerosis (SSc)." | ( Beyer, C; Dees, C; Distler, A; Distler, JH; Distler, O; Gelse, K; Khodzhigorova, A; Lang, V; Schett, G; Schneider, H, 2012) |
| "Intestinal fibrosis is a common and severe complication of inflammatory bowel disease (IBD), especially Crohn's disease (CD)." | ( Asakura, H; Kawachi, H; Kawase, T; Kawauchi, Y; Nagata, M; Sukumaran, V; Suzuki, K; Takagi, R; Thandavarayan, RA; Tomita, M; Watanabe, K; Yamaguchi, H; Yokoyama, J; Yoneyama, H, 2012) |
| "Renal fibrosis is a common cause of renal dysfunction with chronic kidney disease." | ( Itoh, H; Sanagi, M; Tahara, A; Takakura, K; Tomura, Y, 2012) |
| "Radiation-induced fibrosis is a serious late complication of radiotherapy." | ( Delanian, S; Gilbert-Sirieix, M; Hamama, S; Vozenin, MC, 2012) |
| "Fibrosis is a major cause of morbidity and mortality worldwide." | ( Henderson, NC; Sheppard, D, 2013) |
| "Fibrosis is initiated by a variety of pathological, physiological, biochemical, and physical factors." | ( Cheng, NS; Deng, YL; Xiong, XZ, 2012) |
| "Fibrosis is a major contributor to joint stiffness in osteoarthritis (OA)." | ( Bank, RA; Blaney Davidson, EN; Blom, AB; Remst, DF; Snabel, JM; Stoop, R; van den Berg, WB; van der Kraan, PM; Vitters, EL, 2013) |
| "Dermal fibrosis is a disabling late toxicity of radiotherapy." | ( Chung, EJ; Citrin, DE; Horton, JA; Hudak, KE; Mitchell, JB; Sowers, A; Thetford, A; White, AO, 2013) |
| "Renal fibrosis is a major hallmark of chronic kidney disease, regardless of the initial causes, and prominent renal fibrosis predicts poor prognosis for renal insufficiency." | ( Yanagita, M, 2012) |
| "Renal interstitial fibrosis is a major complication of cisplatin (CP) treatment, and increased sodium intake may accelerate its progression by stimulating transforming growth factor (TGF)-β/Smad signaling." | ( Jo, CH; Kim, GH; Kim, S; Park, JS, 2013) |
| "Fibrosis is an abnormal response to organ injury, characterized by accumulation of activated fibroblasts at the sites of injury." | ( Horie, M; Jo, T; Kase, M; Kohyama, T; Mikami, Y; Nagase, T; Takizawa, H; Yamauchi, Y, 2012) |
| "Congenital orbital fibrosis is an orbital disease occurs at birth and is characterized with series of signs such as endophthalmos or exophthalmos, ocular dyskinesia and diplopia." | ( Lu, XZ; Su, F; Wang, Y; Xiao, LH; Yang, XJ; Zhao, HP; Zhu, H, 2012) |
| "Renal interstitial fibrosis is characterized by increased extracellular matrix (ECM) synthesis." | ( Chang, SY; Chen, PY; Chuang, LY; Guh, JY; Hsieh, PF; Hung, CY; Hung, TJ; Hung, YJ; Lee, TC; Liu, SF; Yang, YL, 2012) |
| "Renal fibrosis is the culmination of processes driven by signaling pathways involving transforming growth factor-β family of cytokines, connective-tissue growth factor, nuclear factor κB, Wnt/β-catenin, Notch, and other growth factors." | ( Chuang, PY; He, JC; Menon, MC, 2013) |
| "Cardiac fibrosis is a pathogenic factor in a variety of cardiovascular diseases and is characterized by an abnormal accumulation of extracellular matrix protein that leads to cardiac dysfunction." | ( Arévalo, M; Blanca, AJ; Mate, A; Miguel-Carrasco, JL; Ruiz-Armenta, MV; Vázquez, CM; Vázquez, MJ; Zambrano, S, 2013) |
| "Tissue fibrosis is thought to result from a dysregulated wound healing response as a result of continual local injury or impaired control mechanisms." | ( Chambers, RC; Mercer, PF, 2013) |
| "Fibrosis is the principal characteristic of the autoimmune disease known as scleroderma or systemic sclerosis (SSc)." | ( Iwayama, T; Olson, LE, 2013) |
| "Fibrosis is the feature of Duchenne muscular dystrophy." | ( Fukada, S; Ito, T; Miyagoe-Suzuki, Y; Ogawa, R; Ohtani, T; Takeda, S; Tsujikawa, K; Uezumi, A; Watanabe, Y; Yamamoto, H, 2013) |
| "Liver fibrosis is characterized by excessive deposition of extracellular matrix proteins by myofibroblasts derived from hepatic stellate cells and portal fibroblasts." | ( Georges, PC; Janmey, PA; Perepelyuk, M; Terajima, M; Wang, AY; Wells, RG; Yamauchi, M, 2013) |
| "The degree of fibrosis is routinely analyzed with invasive histological and immunohistochemical methods, giving a limited and qualitative understanding of the tissue's morphological adaptation to disease." | ( Caorsi, V; Ferenczi, MA; Lyon, AR; MacLeod, K; Sikkel, MB; Toepfer, C, 2013) |
| "Cardiac fibrosis is associated with most cardiac diseases." | ( Jiang, J; Xie, J; Yue, L; Yue, Z; Zhang, Y, 2013) |
| "Subepithelial fibrosis is one of the most critical structural changes affecting bronchial airway function during asthma." | ( Al-Jahdali, H; Al-Muhsen, S; Bahammam, AS; Halwani, R; Hamid, Q; Letuve, S; Pureza, MA; Vazquez-Tello, A, 2013) |
| "Renal interstitial fibrosis is a common outcome of chronic renal diseases." | ( Guo, J; Sheng, M; Tan, J; Wu, W; Yang, S, 2013) |
| "Myocardial fibrosis is a hallmark of hypertrophic cardiomyopathy (HCM) and a potential substrate for arrhythmias and heart failure." | ( Abbasi, SA; Chen, Y; Cirino, AL; Díez, J; González, A; Heydari, B; Ho, CY; Jerosch-Herold, M; Kwong, RY; Lakdawala, NK; López, B; Neilan, TG; Orav, EJ; Shah, RV, 2013) |
| "Severe muscle fibrosis is the endpoint of many chronic myopathies." | ( Gibertini, S; Mantegazza, R; Mora, M; Savadori, P; Zanotti, S, 2013) |
| "Fibrosis is a major socioeconomic burden, but effective antifibrotic therapies are not available in the clinical routine." | ( Akan, H; Beyer, C; Dees, C; Distler, A; Distler, JH; Distler, O; Gelse, K; Lin, NY; Mallano, T; Palumbo-Zerr, K; Reichert, H; Schett, G; Schramm, A; Varga, J, 2013) |
| "Cardiac fibrosis is characterized by excessive deposition of extracellular matrix (ECM) and is a common complication of various cardiovascular diseases." | ( Barallobre-Barreiro, J; Didangelos, A; Doménech, N; Mayr, M; Yin, X, 2013) |
| "Liver fibrosis is a reversible wound-healing response involving TGFβ1/SMAD activation of hepatic stellate cells (HSCs)." | ( Atkins, AR; Barish, GD; Coulter, S; Ding, N; Downes, M; Evans, RM; Gunton, JE; He, M; Lau, SL; Leblanc, M; Liddle, C; Rao, R; Scott, C; Sherman, MH; Subramaniam, N; Wilson, C; Yu, RT, 2013) |
| "Atrial fibrosis is considered to contribute to atrial fibrillation (AF) recurrence following cardioversion." | ( Adams, DK; Akar, JG; DeSantis, SM; Gold, MR; McClure, CD; Mukherjee, R; Rice, AD; Spinale, FG; Stroud, RE; Wharton, JM, 2013) |
| "Fibrosis is defined as an abnormal matrix remodeling due to excessive synthesis and accumulation of extracellular matrix proteins in tissues during wound healing or in response to chemical, mechanical and immunological stresses." | ( Ghosh, AK; Kishore, R; Murphy, SB; Vaughan, DE, 2013) |
| "Intestinal fibrosis is a common complication of in inflammatory bowel disease (IBD) and can occur in both ulcerative colitis (UC) and Crohn's disease (CD), but is much more prevalent in CD." | ( Gaudio, E; Latella, G; Sferra, R; Speca, S; Vetuschi, A, 2013) |
| "Skin fibrosis is a severe type of fibrotic disorder emerging in terms of hypertrophic scars or systemic sclerosis." | ( Faust, I; Hendig, D; Knabbe, C; Kuhn, J; Prante, C; Roch, C, 2013) |
| "Fibrosis is a state, in which excess amounts of extracellular matrix are deposited in the tissue." | ( Honda, E; Munakata, H; Park, AM; Tabuchi, M; Yoshida, K, 2013) |
| "Fibrosis is the final disorder of end-stage renal disease." | ( Chen, LJ; Cheng, JT; Cheng, MF; Hsu, CT; Wang, MC, 2014) |
| "Atrial fibrosis is independently associated with appendage thrombus and spontaneous contrast." | ( Akoum, N; Fernandez, G; Kholmovski, E; Marrouche, N; Mcgann, C; Wilson, B, 2013) |
| "Tubulointerstitial fibrosis is a common pathway that leads to kidney failure, and persistent tubulointerstitial inflammation is a key event in the development of tubulointerstitial fibrosis." | ( Chen, JF; Liu, BC; Liu, H; Ma, KL; Ni, HF; Pan, MM; Tang, RN; Zhang, JD; Zhang, MH, 2013) |
| "Fibrosis is characterized by excessive accumulation of scar tissue as a result of exaggerated deposition of extracellular matrix (ECM), leading to tissue contraction and impaired function of the organ." | ( Bhoria, P; Gupta, A; Gupta, V; Luthra-Guptasarma, M; Sharma, M; Sharma, S; Tiwari, A, 2013) |
| "Tubulointerstitial fibrosis is characterized by an accumulation of extracellular matrix in the renal interstitium, myofibroblast activation, cell infiltration, and tubular cell apoptosis, leading to chronic renal failure." | ( López-Novoa, JM; Martínez-Salgado, C; Muñoz-Félix, JM, 2014) |
| "TGF-β signaling and fibrosis are markedly increased in CF (p<0." | ( Ambalavanan, N; Clancy, JP; Hagood, JS; Harris, WT; Kelly, DR; MacEwen, M; Sorscher, EJ; Wang, D; Zhou, Y, 2013) |
| "Myocardial fibrosis is dysrhythmogenic and may contribute to the high incidence of cardiac death in stroke survivors, especially if they have long QTc." | ( MacWalter, RS; McSwiggan, S; Ogston, SA; Struthers, AD; Sze, KY; Wong, KY; Wong, SY, 2013) |
| "Myocardial fibrosis is dysrhythmogenic and may contribute to the high incidence of cardiac death in stroke survivors, especially if they have long QTc." | ( MacWalter, RS; McSwiggan, S; Ogston, SA; Struthers, AD; Sze, KY; Wong, KY; Wong, SY, 2013) |
| "Myocardial fibrosis is considered to be an important factor in myocardial dysfunction and sudden cardiac death in hypertrophic cardiomyopathy (HCM)." | ( Fukushima, K; Hashimura, H; Higashi, M; Ishibashi-Ueda, H; Kiso, K; Kono, A; Morita, Y; Naito, H; Noguchi, T; Sugimura, K; Yamada, N, 2013) |
| "Fibrosis is a common phenomenon associated with several pathologies, characterized by an excessive extracellular matrix deposition that leads to a progressive organ dysfunction." | ( González-Núñez, M; López-Novoa, JM; Muñoz-Félix, JM, 2013) |
| "Renal fibrosis is a common consequence of unilateral ureteral obstruction, which provides a useful model to investigate the pathogenesis of obstructive nephropathy and progressive renal fibrosis." | ( Kang, JM; Kim, SJ; Kim, YW; Lee, SY; Ooshima, A; Park, J; Yang, KM, 2013) |
| "Myocardial fibrosis is one of the key mechanisms and aldosterone is a key mediator of myocardial fibrosis." | ( Heritier, S; Leung, DY; Leung, M; Mihailidou, AS; Wong, VW, 2013) |
| "Prevention of fibrosis is a very important therapeutic strategy in the treatment of obstructive nephropathy (ON)." | ( Acikgoz, A; Acikgoz, Y; Bek, K; Can, B; Genç, G; Ozkaya, O; Sarikaya, S, 2014) |
| "Tissue fibrosis is characterized by excessive production, deposition, and contraction of the extracellular matrix (ECM)." | ( Aroonsakool, N; Insel, PA; Lu, D; Patel, HH; Yokoyama, U, 2013) |
| "Renal fibrosis is a common outcome of chronic kidney disease." | ( Han, J; Liang, J; Tian, S; Xiong, P, 2014) |
| "Fibrosis is characterized by the excessive deposition of extracellular matrix components eventually resulting in organ dysfunction and failure." | ( Babalola, O; Jagdeo, J; Lev-Tov, H; Mamalis, A, 2014) |
| "Cardiac fibrosis is a substantial problem in managing multiple forms of heart disease." | ( Davis, J; Molkentin, JD, 2014) |
| "Myocardial fibrosis is a key process in diabetic cardiomyopathy." | ( Ares-Carrasco, S; Caro-Vadillo, A; Egido, J; Iborra, C; Lorenzo, O; Picatoste, B; Ramírez, E; Tuñón, J, 2013) |
| "Fibrosis is a hallmark of chronic kidney disease, for which there is currently no effective cure." | ( Bathgate, RA; Bosnyak, S; Chow, BS; Hewitson, TD; Jones, ES; Kocan, M; Samuel, CS; Sarwar, M; Summers, RJ; Widdop, RE; Wigg, B, 2014) |
| "Fibrosis is the important pathway for end-stage renal failure." | ( Chang, WT; Chen, MF; Hsieh, PF; Hung, CY; Hung, TJ; Hung, YJ; Liu, SF; Shiue, YL; Wang, WC; Yang, YL, 2014) |
| "Fibrosis is a common and intractable condition associated with various pathologies." | ( Cant, R; Ciechomska, M; O'Reilly, S; van Laar, JM, 2014) |
| "Kidney fibrosis is the final common pathway of all progressive chronic kidney diseases, of which diabetic nephropathy is the leading cause." | ( He, J; Ishigaki, Y; Kanasaki, K; Kanasaki, M; Kitada, M; Koya, D; Nagai, T; Nakamura, Y; Shi, S; Srivastava, SP, 2014) |
| "Synovial fibrosis is a major contributor to joint stiffness in osteoarthritis (OA)." | ( Bank, RA; Blaney Davidson, EN; Blom, AB; Remst, DF; van den Berg, WB; van der Kraan, PM; Vitters, EL, 2014) |
| "Cardiac fibrosis is implicated in numerous physiologic and pathologic conditions, including scar formation, heart failure and cardiac arrhythmias." | ( Long, CS; McKinsey, TA; Schuetze, KB, 2014) |
| "Cardiac fibrosis is involved in a lot of cardiovascular pathological processes." | ( Chen, S; Guo, J; Jia, Y; Jiang, J; Liu, P; Xiao, C; Yu, Y, 2014) |
| "Fibrosis is characterized by the development and persistence of myofibroblasts, whose unregulated deposition of extracellular matrix components disrupts signaling cascades and normal tissue architecture leading to organ failure and death." | ( Berger, P; Sampson, N; Zenzmaier, C, 2014) |
| "Kidney fibrosis is a typical feature of chronic kidney disease and is characterized as an expansion of the interstitium due to increases in extracellular matrix molecules and interstitial cells caused by accumulations of extrarenal cells and by the proliferation or differentiation of intrarenal cells." | ( Han, SJ; Jang, HS; Kim, JI; Park, KM, 2014) |
| "Cardiac fibrosis is a final outcome of many clinical conditions that lead to cardiac failure and is characterized by a progressive substitution of cellular elements by extracellular-matrix proteins, such as collagen type I, collagen type II, connective tissue growth factor (CTGF), etc." | ( Gupta, S; Li, L; Thakur, S, 2014) |
| "Progression of fibrosis is an important clinical issue and monitoring is required for new therapeutic approaches." | ( Bedekovics, J; Beke, L; Fazekas, A; Méhes, G; Szeghalmy, S, 2014) |
| "Renal fibrosis is a common progressive kidney disease, and there is a lack of efficient treatment for the condition." | ( Chen, M; Gao, Y; Gu, X; Li, H; Ping, Q; Qi, J; Qiao, H; Su, Z; Sun, M; Xie, Y; Zhao, Q; Zong, L, 2014) |
| "Muscle fibrosis is also thought to have a role in determining muscle compliance at the time of surgery." | ( Feeley, BT; Joshi, SK; Kim, HT; Laron, D; Liu, X; Ravishankar, B, 2014) |
| "Cardiac fibrosis is an important process in pathological cardiac remodeling and leads to heart failure." | ( Jia, P; Li, Z; Lu, H; Tian, A; Wu, J; Xing, R; Yang, C; Yang, L; Zhang, Y; Zheng, X, 2014) |
| "Fibrosis is an essential component of structural remodeling that accompanies different cardiovascular disease conditions." | ( Akoum, N; Marrouche, N, 2014) |
| "Fibrosis is the most common side effect after anti-vascular epithelial growth factor (VEGF) therapy (intravitreal bevacizumab) for retinal or choroidal neovascularization." | ( Chu, S; Xu, H; Zeng, F; Zhang, M, 2015) |
| "Biliary fibrosis is a major complication after donation after cardiac death (DCD) liver transplantation." | ( Chen, G; Chen, L; Fan, W; Guo, Y; Liu, L; Qian, Y; Shi, B; Xiao, L, 2014) |
| "Arthrofibrosis is a major obstacle to restoring joint function after trauma." | ( Dahners, LE; Efird, W; Kellam, P; Weinhold, P; Yeazell, S, 2014) |
| "Renal fibrosis is the final common pathway of a wide variety of chronic kidney diseases." | ( Ikeda, K; Kanno, Y; Kawashita, E; Kokado, A; Kuretake, H; Matsuno, H; Matsuo, O; Okada, K; Seishima, M; Ueshima, S, 2014) |
| "Tubulointerstitial fibrosis is a major feature of chronic kidney disease." | ( Arévalo, M; Docherty, NG; Eleno, N; Fuentes-Calvo, I; Grande, MT; López-Novoa, JM; Pérez-Barriocanal, F; Rodríguez-Peña, AB, 2014) |
| "Kidney fibrosis is a common feature of chronic kidney disease (CKD)." | ( Dong, Y; Du, J; Jia, L; Li, H; Peng, X; Xiao, Z; Zhang, J, 2014) |
| "Renal fibrosis is a major hallmark of chronic kidney disease that is considered to be a common end point of various types of renal disease." | ( Mack, M; Yanagita, M, 2015) |
| "Renal fibrosis is characterized by the excessive accumulation of extracellular matrix (ECM) proteins such as type I collagen, fibronectin, and by the increased expression of PAI-1." | ( Bae, YS; Chang, YC; Cho, HJ; Choe, JY; Choi, YH; Han, SM; Jeong, YJ; Kang, JH; Kim, WJ; Moon, SK; Park, KK; Park, SH; Park, YY; Shin, JM, 2014) |
| "Renal fibrosis is the final common pathway leading to decreased renal function." | ( Ishibashi, K; Kusano, E; Morishita, Y; Muto, S; Nagata, D; Watanabe, M; Yoshizawa, H, 2014) |
| "Fibrosis is a major hallmark of progressive kidney disease." | ( Portilla, D, 2014) |
| "Fibrosis is the end result of chronic inflammatory reactions induced by a variety of stimuli, and the key cellular mediator of fibrosis comprises the myofibroblasts which, when activated, serve as the primary collagen-producing cells." | ( Pines, M, 2014) |
| "Epidural fibrosis is nonphysiological scar formation, usually at the site of neurosurgical access into the spinal canal, in the intimate vicinity of and around the origin of the radicular sheath." | ( Atalay, FO; Dogan, S; Isık, S; Taşkapılıoğlu, MÖ, 2015) |
| "Epidural fibrosis is a major challenge in spine surgery, with some patients having recurrent symptoms secondary to excessive formation of scar tissue resulting in neurologic compression." | ( Gökçe, A; Gökçe, EC; Gürer, B; Kahveci, R; Ozevren, H; Turkoglu, E, 2015) |
| "Renal fibrosis is mainly characterized by activation and proliferation of interstitial fibroblasts and by excessive synthesis and accumulation of extracellular matrix (ECM) components, including fibronectin (FN) and collagen." | ( Wang, W; Xu, C; Zhang, J; Zhou, X, 2014) |
| "Fibrosis is generally characterized by an excessive accumulation and deposition of extracellular matrix (ECM) that progressively leads to the destruction of functional nephrons of the kidney." | ( Bhatnagar, I; Kim, SK, 2015) |
| "Fibrosis is an inherent response to chronic damage upon immense apoptosis or necrosis." | ( Kim, DK; Kim, JS; Kim, MJ; Lee, SJ; Nam, JS; Park, SA; Park, SY; Sheen, YY; Woo, HA, 2015) |
| ": Interstitial fibrosis is a common pathological change in various heart diseases, especially cardiac hypertrophy." | ( He, Y; Li, X; Niu, X; Xu, M; Xue, Y; Zhao, L; Zhao, X, 2014) |
| "Fibrosis is concomitant with repair processes following injuries in the central nervous system (CNS)." | ( Ago, T; Arimura, K; Kamouchi, M; Kitazono, T; Kuroda, J; Makihara, N; Matsuo, R; Nakamura, K; Nishimura, A; Sugimori, H; Tachibana, M; Wakisaka, Y, 2015) |
| "Fibrosis is induced by the excessive and abnormal deposition of extracellular matrix (ECM) with various growth factors in tissues." | ( Lee, MK; Park, JH; Yoon, J, 2015) |
| "Kidney fibrosis is the final common pathway for virtually every type of chronic kidney disease and is a consequence of a prolonged healing response that follows tissue inflammation." | ( Choi, U; Karihaloo, A; Lee, Y; Moeckel, G; Yuan, A, 2015) |
| "Kidney fibrosis is an important factor for the progression of kidney diseases, e." | ( Schinner, E; Schlossmann, J; Wetzl, V, 2015) |
| "Intestinal fibrosis is a serious and often recurrent complication of inflammatory bowel disease despite surgical intervention." | ( Baird, AC; Lawrance, IC; Lloyd, F, 2015) |
| "Renal fibrosis is a final common feature that contributes to the progression of CKD; however, little is known about the association between renal iron accumulation and renal interstitial fibrosis in CKD." | ( Eguchi, A; Fujii, A; Hirotani, S; Iwasaku, T; Masuyama, T; Morisawa, D; Naito, Y; Oboshi, M; Okuhara, Y; Sawada, H, 2015) |
| "Fibrosis is one of the characteristic features of chronic kidney disease (CKD)." | ( Bo, Y; Cheng, H; Jia, Z; Li, F; Shen, W; Tan, J; Xu, C, 2015) |
| "Cardiac fibrosis is a common feature of advanced coronary heart disease and is characteristic of heart disease." | ( Bai, Y; Fan, TP; Li, Z; Lu, H; Tian, A; Wu, J; Yang, C; Yang, Q; Yin, Q; Zhang, Y; Zheng, X, 2015) |
| "Although fibrosis is becoming increasingly recognized as a major cause of morbidity and mortality in chronic inflammatory diseases, available treatment strategies are limited." | ( Hammarström, C; Haraldsen, G; Kasprzycka, M, 2015) |
| "Intestinal fibrosis is a critical complication of Crohn's disease (CD)." | ( Higgins, PD; Huang, S; Johnson, LA; Rodansky, ES; Spence, JR, 2015) |
| "Inflammation and fibrosis are implicated in the pathogenesis of hypertensive kidney damage." | ( Cho, JY; Cho, SN; Choi, SY; Jeong, MH; Kee, HJ; Kim, GR; Kim, HS; Kim, IK; Ryu, Y, 2015) |
| "Pulmonary fibrosis is a respiratory disease with a high mortality rate and its pathogenesis involves multiple mechanisms including epithelial cell injury, fibroblast proliferation, inflammation, and collagen coagulation." | ( Fu, Q; Li, N; Liu, T; Lv, C; Qiu, X; Sun, Y; Wang, L; Yang, D; Yuan, W, 2015) |
| "Lung fibrosis is a poor prognostic factor for pulmonary adenocarcinoma, and the effect of a rigid microenvironment on cancer behavior is unclear." | ( Chang, CC; Ho, JH; Hsiao, CH; Hsieh, TL; Hsu, WT; Ji, AT; Lee, OK; Tiong, TY, 2015) |
| "Renal fibrosis is a final common manifestation of CKD resulting in progressive loss of kidney function." | ( Mitch, WE; Wang, Y; Yan, J; Yang, J; Zhang, Z, 2015) |
| "Marked fibrosis is less common in the lacrimal gland compared with orbital adipose tissue." | ( Al Hussain, H; Alabiad, C; Alkatan, H; Choi, D; Czyz, CN; Dailey, RA; Dolman, P; Dubovy, S; Edward, DP; Foster, JA; Grossniklaus, HE; Harrington, CA; Harris, GJ; Kazim, M; Kikkawa, D; Korn, B; Ng, JD; Parekh, P; Patel, P; Planck, SR; Rosenbaum, JT; Selva, D; Stauffer, P; Steele, EA; Tse, D; White, V; Wilson, DJ; Yeatts, P, 2015) |
| "Fibrosis is one of the leading causes of morbidity and mortality in the Western world." | ( Dalm, V; Dik, WA; Thio, HB; van Daele, PL; van den Blink, B; van Hagen, PM, 2015) |
| "Renal fibrosis is a crucial event in the pathogenesis of diabetic nephropathy (DN)." | ( Choi, YJ; Kang, MK; Kang, YH; Park, SH; Shin, D, 2015) |
| "Chronic renal fibrosis is the final common pathway of end stage renal disease caused by glomerular or tubular pathologies." | ( Csont, T; Erdélyi, K; Godó, M; Hamar, P; Kaucsár, T; Kiss, N; Kökény, G; Krenács, T; Lajtár, E; Pacher, P; Révész, C; Sárközy, M; Szalay, CI; Szénási, G, 2015) |
| "Renal fibrosis is a serious clinical problem resulting in the greatest need for renal replacement therapy." | ( Hillebrands, JL; Olinga, P; Oosterhuis, D; Pham, BT; Poelstra, K; Poosti, F; van Goor, H, 2015) |
| "Bone marrow (BM) fibrosis is associated with poor prognosis in patients with de novo myelodysplastic syndromes (MDS)." | ( Al-Ibraheemi, A; Bueso-Ramos, CE; Garcia-Manero, G; Kantarjian, HM; Khoury, JD; Loghavi, S; Luthra, R; Medeiros, LJ; Miranda, RN; Wang, SA; Yabe, M; Yin, CC; Zuo, Z, 2015) |
| "Synovial fibrosis is often found in OA, contributing heavily to joint pain and joint stiffness, the main symptoms of OA." | ( Blaney Davidson, EN; Remst, DF; van der Kraan, PM, 2015) |
| "Tissue fibrosis is a maladaptive repair process following injury, associated with oxidative stress." | ( Jang, HS; Kim, HY; Kim, JI; Kim, KY; Noh, MR; Park, KM, 2015) |
| "Cardiac fibrosis is an important causative mechanism of HF associated with diabetes." | ( Byrne, M; Chu, PY; Horlock, D; Jandeleit-Dahm, K; Kaye, DM; Nelson, E; Walder, K; Williams, D; Zimmet, P, 2015) |
| "Pancreatic fibrosis is a prominent histopathological characteristic of chronic pancreatitis and plausibly a dynamic process of transition to the development of pancreatic ductal adenocarcinoma." | ( Bian, ZX; Lin, Z; Tsang, SW; Zhang, HJ; Zheng, LC, 2015) |
| "Fibrosis is one postulated pathway by which diabetes produces cardiac and other systemic complications." | ( Agarwal, I; Barasch, E; Djousse, L; Glazer, NL; Gottdiener, JS; Ix, JH; King, GL; Kizer, JR; Mukamal, KJ; Rimm, EB; Siscovick, DS, 2015) |
| "Primary myelofibrosis is a stem cell-derived clonal malignancy characterized by unchecked proliferation of myeloid cells, resulting in bone marrow fibrosis, osteosclerosis, and pathologic angiogenesis." | ( Daver, N; Khoury, JD; Nazha, A; Rampal, RK, 2015) |
| "Liver fibrosis is an integral stage in the development of chronic liver disease, and transforming growth factor β (TGFβ) is known to play a central role in the progression of this entity." | ( Fukuda, N; Fukushima, A; Inami, M; Matsumoto, Y; Moriyama, M; Soma, M; Tsunemi, A; Ueno, T; Yamada, T, 2015) |
| "Cardiac fibrosis is characterized by net accumulation of extracellular matrix proteins in the cardiac interstitium, and contributes to both systolic and diastolic dysfunction in many cardiac pathophysiologic conditions." | ( Hu, W; Li, J; Shi, KH; Tao, H; Yang, JJ, 2016) |
| "Fibrosis is a chronic disorder affecting many organs." | ( Bank, RA; Mia, MM, 2016) |
| "Renal fibrosis is an inevitable outcome of chronic kidney disease (CKD)." | ( Cao, H; Dai, C; Fang, L; Jiang, L; Niu, J; Sun, Q; Yang, J; Yu, Y; Zen, K; Zhou, Y, 2016) |
| "Skin fibrosis is a significant medical problem that leads to a functional, aesthetic, and psychosocial impact on quality-of-life." | ( Isseroff, RR; Jagdeo, J; Koo, E; Mamalis, A; Murphy, W, 2015) |
| "Renal fibrosis is the major cause of chronic kidney disease, and the Rho/Rho-associated coiled-coil kinase (ROCK) signaling cascade is involved in the renal fibrotic processes." | ( Baba, I; Egi, Y; Kakimoto, T; Suzuki, K; Utsumi, H, 2015) |
| "Intestinal fibrosis is mainly associated with Crohn's disease and is defined as a progressive and excessive deposition of extracellular matrix components." | ( Bertin, B; Desreumaux, P; Dubuquoy, C; Dubuquoy, L; Gaudio, E; Giusti, I; Latella, G; Rieder, F; Rousseaux, C; Sferra, R; Speca, S; Vetuschi, A, 2016) |
| "Renal fibrosis is a main cause of end-stage renal disease." | ( Cao, Y; Li, L; Long, Y; Rong, R; Xu, M; Yang, C; Zhang, Y; Zhu, T, 2015) |
| "Cardiac fibrosis is one of the major components of the healing mechanism following any injury of the heart and as such may contribute to both systolic and diastolic dysfunction in a range of pathophysiologic conditions." | ( Chen, C; Li, R; Manso, AM; Ross, RS, 2016) |
| "Renal fibrosis is a well‑known cause for the progression of chronic kidney disease." | ( Baba, I; Egi, Y; Suzuki, K, 2016) |
| "Myocardial fibrosis is frequently observed and may be associated with the prognosis in patients with hypertrophic cardiomyopathy (HCM); however, the clinical pathophysiological features, particularly in terms of fibrosis, of hypertrophic obstructive cardiomyopathy (HOCM) remain unclear." | ( Iwanaga, Y; Kawamura, T; Miyaji, Y; Miyazaki, S; Morooka, H; Nakamura, T; Yasuda, M, 2016) |
| "Cardiac fibrosis is an important pathological process of cardiac remodeling." | ( Cui, QW; Guan, GC; Liu, B; Tian, G; Wang, JK; Zhang, Y; Zhao, NA; Zhu, HL; Zhu, SM, 2015) |
| "Myocardial fibrosis is the predominant pathological characteristic of diabetic myocardial damage." | ( Li, F; Luo, J; Wu, Z; Xiao, T; Yang, J; Zeng, O, 2016) |
| "Fibrosis is a common occurrence following organ injury and failure." | ( Deng, C; Di, S; Fan, C; Hu, W; Jiang, S; Lv, J; Ma, Z; Reiter, RJ; Yan, X; Yang, Y, 2016) |
| "Focal myocardial fibrosis is prevalent in patients with rTOF." | ( Chen, CA; Dusenbery, SM; Geva, T; Powell, AJ; Valente, AM, 2016) |
| "Cochlear fibrosis is a common finding following cochlear implantation." | ( Bourien, J; Eybalin, M; François, F; Jia, H; Lloyd, RV; Puel, JL; Van De Water, TR; Venail, F, 2016) |
| "Myocardial fibrosis is an essential hallmark of diabetic cardiomyopathy (DCM) contributing to cardiac dysfunctions." | ( Chen, JZ; Chen, QH; Kang, LN; Li, GN; Li, R; Wei, ZH; Wu, H; Xie, J; Xu, B, 2016) |
| "Cardiac fibrosis is a major cause of heart failure." | ( Chen, L; Deng, L; Guo, X; Leng, B; Liu, X; Lv, L; Qiao, G; Shan, H; Xu, W; Yao, Z; Zhao, D; Zhou, Y, 2016) |
| "Fibrosis is a general term encompassing a plethora of pathologies that span all systems and is marked by increased deposition of collagen." | ( Beauloye, C; Bertrand, L; Daskalopoulos, EP; Dufeys, C; Horman, S, 2016) |
| "Myocardial fibrosis is a risk factor for sudden cardiac death in hypertrophic cardiomyopathy (HCM) and is conventionally identified by cardiac magnetic resonance imaging (CMR) using late gadolinium enhancement (LGE)." | ( Bogarapu, S; Everitt, MD; Menon, SC; Puchalski, MD; Weng, HY; Williams, RV, 2016) |
| "Renal fibrosis is the usual outcome of an excessive accumulation of extracellular matrix (ECM) that frequently occurs in membranous and diabetic nephropathy." | ( Jhonsa, D; Saraf, MN; Sutariya, B, 2016) |
| "Corneal fibrosis is often seen in patients with ocular trauma and infection that compromises corneal transparency resulting in vision loss." | ( Barathi, VA; Chaurasia, SS; Lim, RR; Liu, YC; Mehta, JS; Mohan, RR; Tan, A, 2016) |
| "Kidney fibrosis is the most common final stage of progressive renal disease." | ( Cao, J; Li, Y; Peng, Y; Wang, W; Xia, A; Xia, J; Zhang, Y, 2016) |
| "Renal fibrosis is a common final pathway of end-stage kidney disease which is induced by aberrant accumulation of myofibroblasts." | ( Bae, EH; Choi, HI; Kim, SW; Lee, J; Ma, SK, 2016) |
| "Inflammation and fibrosis are frequently triggered by various signals such as proinflammatory cytokines and chemokines, released by injuried hepatocytes and activated Kupffer cells." | ( Baker, RD; Baker, SS; Bhatia, T; Liu, W; Zhu, L, 2016) |
| "Fibrosis is a major contributor to systemic sclerosis (SSc)-related morbidity, and rapid, progressive skin involvement predicts later mortality." | ( Bi, Y; Bian, H; Han, L; Ouyang, J; Yang, L; Ye, S, 2016) |
| "Tubulo-interstitial fibrosis is a common, destructive endpoint for a variety of kidney diseases." | ( Hu, J; Kuro-o, M; Malter, JS; Shen, ZJ; Shiizaki, K, 2016) |
| "Kidney fibrosis is related to scarring after acute kidney injury and the progression of chronic kidney disease." | ( Kuma, A; Otsuji, Y; Tamura, M, 2016) |
| "Cardiac fibrosis is an important pathological feature of cardiac remodeling in heart diseases." | ( Li, J; Shi, KH; Tao, H; Yang, JJ, 2016) |
| "Renal interstitial fibrosis is characterized by excessive accumulation of extracellular matrix, which leads to end-stage renal failure." | ( Jung, JY; Kim, HT; Kim, TW; Kim, YJ; Lee, MY; Park, SR; Seo, CS, 2016) |
| "Hypoxia and fibrosis are early causes of adipose dysfunction in obesity." | ( Huang, F; Kou, J; Li, A; Li, J; Li, X; Liu, B; Liu, K; Qi, LW; Qiu, Z; Wang, L, 2016) |
| "Renal fibrosis is the common pathological foundation of many chronic kidney diseases (CKDs)." | ( Chu, J; Duan, J; Hu, N; Li, H; Liu, M; Lu, C; Sun, J; Wang, C; Wang, F; Wang, Y; Wen, A, 2016) |
| "Fibrosis is an ominous pathological process in failing myocardium, but its pathogenesis is poorly understood." | ( Chu, ML; Dong, H; Joyce, J; Khan, SA; Sasaki, T; Tsuda, T, 2016) |
| "Epidural fibrosis is a common complication after laminectomy." | ( Chen, H; Dai, J; He, J; Li, X; Sun, Y; Wang, D; Wang, J; Yan, L; Zhao, S, 2016) |
| "Myocardial fibrosis is the endpoint pathology common to many cardiovascular disorders." | ( Chen, Y; Cui, J; Du, X; Wang, P; Wang, W; Yang, Q; Zhang, T, 2016) |
| "Fibrosis is a final common pathway leading to loss of kidney function, in which the fibrogenic cytokine, transforming growth factor β (TGF-β), plays a central role." | ( Hayashida, T; Ledbetter, S; Liang, X; Matsusaka, T; Pastan, I; Schnaper, HW, 2016) |
| "Renal fibrosis is the common feature of chronic kidney disease and mainly mediated by TGFβ-associated pro-fibrogenic signaling, which causes excessive extracellular matrix accumulation and successive loss of kidney functions." | ( Cao, W; Huang, F; Liu, Y; Qin, T; Yang, J; Yin, S; Zhang, Q, 2016) |
| "Interstitial fibrosis is seen in >90% of patients distributed in both the atria and is independent of the rhythm." | ( Kalpana, SR; Kamlapurkar, G; Nagashetty, RK; Prabhu, MA; Rai, MK; Shenthar, J, 2016) |
| "Pleural fibrosis is defined as an excessive deposition of extracellular matrix (ECM) components that results in destruction of the normal pleural tissue architecture." | ( Cai, PC; Greer, PA; Li, FZ; Lu, YZ; Ma, WL; Shi, HZ; Su, Y; Xiang, F; Xin, JB; Xu, XX; Yang, J; Ye, H; Yu, F; Zhou, Q, 2016) |
| "Fibrosis is often involved in the pathogenesis of various chronic progressive diseases such as interstitial pulmonary disease." | ( Makita, K; Matsuzaki, H; Mikami, Y; Nagase, T; Takeshima, H; Yamauchi, Y, 2016) |
| "Tubulointerstitial fibrosis is a major feature associated with declining kidney function in chronic kidney disease of diverse etiology." | ( Chen, X; Gao, B; Krepinsky, JC; Mustafa, M; Wang, TN, 2016) |
| "Cardiac fibrosis is extremely difficult and challenging to treat in a clinical setting due to lack of understanding of molecular mechanisms leading to cardiac fibrosis and effective anti-fibrotic therapies." | ( Agellon, LB; Dyck, JR; Groenendyk, J; Jung, J; Lee, D; Lopaschuk, GD; Michalak, M, 2016) |
| "Renal interstitial fibrosis is a major pathologic feature of diabetic nephropathy, while the pathogenesis and therapeutic interventions of diabetic renal interstitial fibrosis are not well established." | ( Guan, X; He, T; Huang, Y; Liu, L; Nie, L; Sharma, K; Wang, J; Xiao, T; Xiong, J; Xu, X; Yang, K; Yu, Y; Zhang, D; Zhang, J; Zhao, J, 2016) |
| "Chronic allograft fibrosis is the major cause of graft loss in kidney transplantation." | ( Hamar, P; Kerjaschki, D, 2016) |
| "Cardiac fibrosis is a common pathological process accompanying diabetes mellitus." | ( Chen, X; Du, Z; Liang, E; Liu, X; Lu, J; Song, X; Zhang, M; Zhang, Y; Zhao, Y, 2016) |
| "Fibrosis is a characteristic of Duchenne muscular dystrophy (DMD), yet the cellular and molecular mechanisms responsible for DMD fibrosis are poorly understood." | ( Duffield, JS; Hays, A; Ieronimakis, N; Janebodin, K; Prasad, A; Reyes, M, 2016) |
| "Renal fibrosis is a common irreversible process of chronic kidney disease (CKD) characterized by uncontrolled deposits of extracellular matrix, replacement of cellular parenchyma and progressive loss of renal function." | ( Alarcón, S; San Martín, R; Vega, G, 2016) |
| "Renal fibrosis is the principal pathological process underlying the progression of chronic kidney disease that leads to end-stage renal disease." | ( An, HJ; Han, SM; Kim, JY; Kim, WH; Park, KK, 2016) |
| "Hence, renal fibrosis is one of the underlying mechanisms by which Cd40 plays a crucial role in the development of hypertensive renal disease." | ( Chaudhry, M; Cooper, CJ; Drummond, CA; Filipiak, WE; Folt, DA; Haller, ST; Joe, B; Karamchandani, M; Kumarasamy, S; Maxwell, K; Mell, B; Saunders, TL; Shapiro, JI; Stepkowski, S; Tian, J; Upadhyaya, S; Waghulde, H; Wuescher, LM, 2017) |
| "Renal fibrosis is the hallmark of chronic kidney diseases (CKD) and its development and progression are significantly affected by epigenetic modifications." | ( Cao, W; Liu, L; Liu, Z; Yin, S; Zhang, Q, 2016) |
| "Renal fibrosis is characterized by glomerulosclerosis and tubulointerstitial fibrosis." | ( Mukoyama, M; Yokoi, H, 2017) |
| "Fibrosis is a complication of chronic inflammatory disorders such as inflammatory bowel disease, a condition which has limited therapeutic options and often requires surgical intervention." | ( Barrett, KE; Brown, E; Cavadas, MA; Cheong, A; Cummins, EP; Harnoss, JM; Keogh, CE; Manresa, MC; Radhakrishnan, P; Schneider, M; Tambuwala, MM; Taylor, CT, 2016) |
| "Renal fibrosis is characterized by infiltration of inflammatory cells, activation and proliferation of fibroblasts, and accumulation of extracellular matrix (ECM)." | ( Chen, C; Gong, X; Shan, G; Sun, X; Yang, Y; Yao, Q; Zhou, X, 2017) |
| "Fibrosis is the final pathological outcome of many chronic kidney diseases and is quite common." | ( Jang, WH; Kang, MS; Kang, SW; Kim, JY; Kim, SY; Kim, TH; Kim, YH; Lee, SM; Seo, SK, 2017) |
| "Renal fibrosis is a common pathological feature of the progression of chronic kidney disease." | ( Doi, S; Doi, T; Kawaoka, K; Masaki, T; Nakashima, A; Ueno, T; Yamada, K, 2017) |
| "Renal fibrosis is the final common pathway of chronic renal disease." | ( Covic, A; Kanbay, M; Ortiz, A; Siriopol, D; Solak, Y; Yildiz, A; Yilmaz, MI, 2017) |
| "Dermal fibrosis is characterized by the activation of the matrix-producing 'positive' myofibroblasts, and the relentless production and deposition of extracellular matrix." | ( Cai, SQ; Cao, HL; Chen, JQ; Chen, XB; Landeck, L; Li, W; Man, XY; Yang, JQ; Zheng, M; Zhou, J, 2016) |
| "Skin fibrosis is the predominant feature of SSc and arises from excessive extracellular matrix deposition." | ( Beyer, C; Cavallaro, A; Dahlmann, A; Distler, JHW; Eckardt, KU; Hammon, M; Jantsch, J; Kopp, C; Linz, P; Luft, FC; Müller, DN; Neubert, P; Rosenhauer, D; Schett, G; Titze, J; Uder, M, 2017) |
| "Liver fibrosis is the net result of dynamic changes between fibrogenesis and fibrolysis." | ( Chen, G; Chen, S; Chen, Y; Ding, H; Feng, B; Jia, J; Jiang, W; Li, H; Liu, H; Lu, L; Lv, F; Nan, Y; Ou, X; Piao, H; Shao, C; Sun, Y; Theise, ND; Wang, B; Wang, L; Wang, T; Wee, A; Wu, X; Xie, W; Xu, Y; You, H; Zheng, H; Zhou, J, 2017) |
| "Fibrosis is a complex chronic disease characterized by a persistent repair response." | ( Di Battista, JA; Gerarduzzi, C, 2017) |
| "Renal fibrosis is the common pathological hallmark of progressive chronic kidney disease (CKD) with diverse aetiologies." | ( Li, R; Liu, M; Ning, X; Qian, Q; Sun, S; Yang, X; Yang, Z, 2017) |
| "Fibrosis is a common pathological state characterized by the excessive accumulation of extracellular matrix components, but the pathogenesis of the disease is still not clear." | ( Deng, Z; He, L; He, Y; Lu, L; Shi, A; Shi, H; Yang, X, 2017) |
| "Biliary fibrosis is a complex process in which macrophages and myofibroblasts may play central roles." | ( Bondoc, A; Golbar, HM; Izawa, T; Kuwamura, M; Tennakoon, AH; Wijesundera, KK; Yamate, J, 2017) |
| "Intestinal fibrosis is characterized by abnormal production and deposition of extracellular matrix (ECM) proteins by activated myofibroblasts." | ( Cristiano, L; Desreumaux, P; Di Gregorio, J; Dubuquoy, C; Flati, V; Gaudio, E; Latella, G; Pompili, S; Sferra, R; Speca, S; Vetuschi, A, 2017) |
| "Fibrosis is the unifying pathway leading to chronic kidney disease." | ( Coca, SG; Gentry, M; Mansour, SG; Parikh, CR; Puthumana, J, 2017) |
| "Cardiac fibrosis is considered an important pathological mechanism in the progression of cardiac remodeling and heart failure." | ( Dai, H; Jia, G; Liang, C; Lu, M; Wang, H; Wang, Y, 2017) |
| "Renal fibrosis is a pathological process common to all CKD and thereby represents an excellent treatment target." | ( Boor, P; Floege, J; Goldschmeding, R; Klinkhammer, BM, 2017) |
| "Renal fibrosis is a common pathological feature of chronic kidney diseases (CKD) and its development and progression are significantly affected by epigenetic modifications such as aberrant miRNA and DNA methylation." | ( Cao, W; Chen, F; Li, Y; Lin, W; Yang, J; Yin, S; Zhang, Q, 2017) |
| "Renal fibrosis is the final common pathway of all varieties of progressive chronic kidney disease." | ( Chang, X; Ding, K; Hu, Z; Liu, J; Nie, J; Ren, X; Zhen, X; Zhou, Z; Zhu, F, 2017) |
| "LF hypertrophy and fibrosis are important causes of LSS." | ( Ding, W; Li, H; Liu, XY; Sun, W; Sun, XJ; You-Zhuan, X; Zhang, K; Zhao, CQ; Zhao, J, 2017) |
| "Bladder wall fibrosis is a major complication of ketamine-induced cystitis (KC), but the underlying pathogenesis is poorly understood." | ( Chen, J; Chen, Y; Gu, D; Wang, J; Wu, P; Zhang, G; Zhao, J, 2017) |
| "Radiation-induced fibrosis is widely considered as a common but forsaken phenomenon that can lead to clinical sequela and possibly vital impairments." | ( Ben-Mrad, M; El Meddeb Hamrouni, A; Espenel, S; Guy, JB; Langrand-Escure, J; Magné, N; Rancoule, C; Rehailia-Blanchard, A; Trone, JC; Vallard, A; Xia, Y, 2017) |
| "Renal fibrosis is a hallmark feature of chronic kidney disease, which is reflected by proliferation and migration of interstitial fibroblasts and extracellular matrix (ECM) accumulation." | ( Qian, J; Sun, B; Wang, H; Xing, C; Zhao, X, 2017) |
| "Fibrosis is a potentially debilitating disease with high morbidity rates." | ( Koh, RY; Lee, SY; Siang, R; Wen, WX, 2017) |
| "Renal fibrosis is the most common outcome of chronic kidney disease (CKD), while the pathogenesis of renal fibrosis is not fully understood." | ( Feng, B; Guan, X; He, T; Huang, Y; Li, Y; Liu, Y; Nie, L; Wang, Y; Xiong, J; Xu, X; Yang, K; Yu, Y; Zhang, J; Zhao, J, 2017) |
| "Fibrosis is a common feature in skeletal muscle under chronic damage conditions such as those caused by muscular dystrophies or denervation." | ( Brandan, E; Contreras, O; Espinoza, JP; Gonzalez, D; Rebolledo, DL; van Zundert, B, 2017) |
| "Cardiac fibrosis is a significant global health problem with limited treatment choices." | ( Chen, GX; Fan, T; Hou, J; Liang, MY; Wang, LX; Wu, ZK; Yang, X; Yue, Y, 2017) |
| "Intestinal fibrosis is a serious complication of inflammatory bowel disease, including Crohn's disease and ulcerative colitis." | ( Hahm, KB; Hong, SP; Jung, Y; Kim, DH; Kim, G; Kim, JW; Koo, JB; Lee, KJ; Lee, KM; Nam, MO; Shin, SJ; Yoo, J; Yoo, JH, 2017) |
| "Fibrosis is a chronic process involving development and progression of multiple diseases in various organs and is responsible for almost half of all known deaths." | ( Bo, Q; Cao, Y; Chen, W; Chen, X; Liu, X; Liu, Y; Luo, Y; Wu, M; Xiao, W; Ye, S, 2017) |
| "Inhibiting renal fibrosis is one of the most promising therapeutic strategies for CKD." | ( Fang, X; Ke, B; Luo, F; Xu, Y; Zhu, N, 2017) |
| "Renal fibrosis is the common final manifestation of chronic kidney diseases and usually results in end-stage renal failure." | ( Shi, D; Tian, T; Wen, S; Zhang, J; Zhou, H; Zhu, X, 2017) |
| "Renal fibrosis is an important factor for end-stage renal failure." | ( Faerber, L; Kees, F; Schinner, E; Schlossmann, J; Wetzl, V, 2017) |
| "BACKGROUND Tissues fibrosis is caused by ischemia-reperfusion injury (IRI) and results in organ dysfunction." | ( He, Y; Lin, L; Liu, Q; Wang, L; Zhang, J, 2017) |
| "Skin fibrosis is a common pathological process characterized by fibroblast proliferation and excessive deposition of extracellular matrix." | ( Chen, T; Lei, Y; Li, Y; Lyu, L; Zhang, J; Zuo, R, 2017) |
| "Renal fibrosis is a common pathway leading to the progression of chronic kidney disease, and bone marrow-derived fibroblasts contribute significantly to the development of renal fibrosis." | ( Hu, Z; Liang, H; Mitch, WE; Wang, Y; Yan, J; Zhang, Z, 2017) |
| "Renal fibrosis is a common pathway through which a variety of chronic kidney diseases progress to end-stage renal disease." | ( Cui, T; Gao, Z; Li, Z; Zhang, H; Zhu, W, 2017) |
| "Cardiac fibrosis is a common feature in left ventricular remodeling that leads to heart failure, regardless of the cause." | ( Cai, Z; Fu, Z; Jia, L; Shen, J; Su, SA; Wang, JA; Wang, Y; Wu, Y; Xiang, M; Xie, Y; Yang, D; Zhu, W, 2017) |
| "Intestinal fibrosis is a common complication of Crohn's disease; however, its mechanism of intestinal fibrosis is largely unclear." | ( Guan, Y; Liu, W; Pan, D; Sun, Y; Tan, Y; Wang, D; Yang, J; Zheng, C, 2018) |
| "Fibrosis is characterized by the accumulation of extracellular matrix proteins in the glomeruli and tubular interstitium." | ( López-Novoa, JM; Mora, I; Müller, AG; Muñoz-Félix, JM; Olmos, G; Rodríguez-Puyol, D; Ruiz-Torres, MP, 2018) |
| "Fibrosis is a frequent adverse effect of radiotherapy and no effective treatments are currently available to prevent or reverse fibrotic disease." | ( Herskind, C; Oakes, CC; Plass, C; Popanda, O; Schmezer, P; Valinciute, G; Veldwijk, MR; Weigel, C; Wenz, F, 2017) |
| "Myocardial fibrosis is a characteristic feature of cardiomyopathies." | ( Hu, C; Ke, X; Liang, J; Wang, X; Wu, S; Yang, D, 2017) |
| "Cardiac fibrosis is characterized by an excessive accumulation of extracellular matrix components, including collagens." | ( Fernández-Celis, A; Fernández-Irigoyen, J; Ibarrola, J; Jaisser, F; López-Andrés, N; Martínez-Martínez, E; Rossignol, P; Santamaria, E, 2017) |
| "Cardiac fibrosis is an important pathological mechanism during cardiac remodelling associated with heart failure." | ( Dai, H; Jia, G; Leng, B; Wang, H, 2017) |
| "Myocardial fibrosis is one of the most important pathological features of alcoholic cardiomyopathy (ACM)." | ( Li, Z; Liang, B; Liu, M; Liu, S; Long, J; Xiao, T; Yang, J, 2017) |
| "Fibrosis is characterised by a surplus of collagen fibre accumulation and is amongst others also a feature of obesity-associated dysfunctional adipose tissue (AT) which has been linked with type 2 diabetes." | ( Knight, B; Kos, K; Liversedge, N; McCulloch, LJ; Møller, N; Pastel, E; Price, E; Rittig, N; Sjöholm, K; Svensson, PA, 2018) |
| "Tissue and organ fibrosis is the major cause for disability and death related to a variety of diseases worldwide." | ( Zhu, QJ, 2017) |
| "Renal fibrosis is the final common pathological feature in a variety of chronic kidney disease." | ( Cai, CJ; Chang, PJ; Hsu, YC; Lin, CL; Shih, YH; Tung, CW; Wang, CJ, 2017) |
| "Pleural fibrosis is associated with various inflammatory processes such as tuberculous pleurisy and bacterial empyema." | ( Greer, PA; Huang, H; Ma, WL; Shi, HZ; Song, LJ; Su, Y; Xiang, F; Xin, JB; Xiong, L; Xu, JJ; Yang, J; Ye, H; Yu, F, 2018) |
| "Pancreatic fibrosis is a key pathological feature of alcoholic chronic pancreatitis (ACP)." | ( Brigstock, DR; Gao, R; Li, H; Qu, L; Sun, L; Wang, S; Xiu, M, 2018) |
| "Cardiac fibrosis is one of the pathological characteristics of diabetic cardiomyopathy (DbCM)." | ( Cui, L; Guan, G; Guo, Y; Liu, Z; Qiu, C; Wang, J; Yang, T; Zhang, Y, 2018) |
| "Renal interstitial fibrosis is one of the most typical features of AAN." | ( Li, J; Li, Y; Mao, Y; Peng, X; Yu, F; Zhang, M; Zhang, X, 2018) |
| "As fibrosis is central in the aging process, we investigated the effect of the intervention on biomarkers of fibrogenic activity in a subanalysis of this intervention study." | ( Aaseth, J; Alehagen, U; Alexander, J; Johansson, P; Larsson, A; Svensson, E, 2018) |
| "Fibrosis is a common complication of Crohn's disease [CD], and is related to dysregulated tissular repair following inflammation, in which macrophages play a central role." | ( Alós, R; Barrachina, MD; Bernardo, D; Calatayud, S; Esplugues, JV; Gisbert-Ferrándiz, L; Hernández, C; Macías-Ceja, DC; Navarro-Vicente, F; Ortiz-Masiá, D; Salvador, P, 2018) |
| "Adipose tissue fibrosis is a hallmark of malfunction that is linked to insulin resistance and type 2 diabetes; however, what regulates this process remains unclear." | ( Alba, DL; Chen, Y; Chi, J; Cohen, P; Hasegawa, Y; Hosono, T; Ikeda, K; Ishigaki, Y; Kajimura, S; Koliwad, SK; Maretich, P; Shinoda, K; Stifler, D; Yang, Y, 2018) |
| "Epidural fibrosis is a challenging topic in spinal surgery." | ( Bayram, P; Billur, D; Bozkurt, G; Bozkurt, I; Erbay, FK; Guvenc, Y; Hayirli, N; Ozturk, Y; Senturk, S; Tolunay, T; Yaman, ME, 2018) |
| "Renal fibrosis is characterized by infiltration of interstitial inflammatory cells and release of inflammatory mediators, activation and proliferation of fibroblasts, and deposition of excessive extracellular matrix (ECM)." | ( Ding, F; Hu, D; Liu, B; Long, C; Shen, L; Wei, G; Zhang, D; Zhang, Y; Zhou, Y, 2018) |
| "Fibrosis is a common feature of several chronic diseases and is characterized by exacerbated accumulation of ECM." | ( Brandan, E; Contreras, O; Riquelme-Guzmán, C, 2018) |
| "Hepatic fibrosis is a physiological response to liver injury that includes a range of cell types." | ( Deng, Q; Lun, W; Wu, X; Zhang, W; Zhi, F, 2018) |
| "Renal fibrosis is a common pathogenic response to injury in chronic kidney disease (CKD)." | ( Choi, AM; Choi, ME; Chung, KP; Imamura, M; Moon, JS; Muthukumar, T; Nakahira, K; Ryter, SW; Shingarev, R, 2018) |
| "Tissue fibrosis is often initiated and sustained through transforming growth factor-β (TGF-β) signaling, and Krüppel-like factor 10 (KLF10) is an immediate early gene that is transcriptionally activated in response to TGF-β signaling." | ( DiMario, JX, 2018) |
| "Cardiac fibrosis is an important cardiac remodeling event that can ultimately lead to the development of severe arrhythmia and heart failure." | ( Gao, Y; Jiao, L; Liu, T; Shan, H; Shao, Y; Yang, B; Yin, H; Zhang, L; Zhang, Y, 2018) |
| "Dermal fibrosis is the pathological formation of excess fibrous connective tissue of the skin, usually the result of traumatic cutaneous injury." | ( Hall, CL; Leung, KP; Wells, AR, 2018) |
| "Sinoatrial node fibrosis is involved in the pathogenesis of sinus sick syndrome (SSS)." | ( Lian, G; Wang, H; Wang, T; Xie, L; Xu, C; Zhong, H, 2018) |
| "Cardiac fibrosis is a major pathological manifestation of diabetic cardiomyopathy (DCM), which leads to cardiac remodeling, dilated cardiomyopathy and congestive heart failure." | ( Guo, H; Meng, L; Tada, H; Uzui, H, 2018) |
| "The development of fibrosis is the most important factor contributing to NASH-associated morbidity and mortality." | ( Andreola, F; De Chiara, F; Jalan, R; Mookerjee, RP; Rombouts, K; Thomsen, KL; Vilstrup, H, 2018) |
| "Renal fibrosis is recognized as the common route of all chronic kidney disease (CKD) progressing to end-stage renal disease (ESRD)." | ( Hu, XF; Li, SL; Li, YK; Ma, DX; Shu, YW; Tian, HZ; Wang, MJ; Wang, ZM; Yang, J, 2018) |
| "Renal fibrosis is a common outcome of nearly all kinds of chronic kidney disease (CKD) and eventually progresses to end-stage renal disease." | ( Bai, F; Liu, W; Qin, N; Sun, Q; Yang, J; Yu, Y; Zhou, Y, 2018) |
| "Epidural fibrosis is a challenging topic in spinal surgery." | ( Bozkurt, G; Erbay, FK; Ergül, G; Güvenç, Y; Kırçıl, C; Öztürk, Y; Şentürk, S; Tolunay, T; Yaman, ME, 2018) |
| "BACKGROUND Fibrosis is the common pathological feature in most kinds of chronic kidney disease (CKD)." | ( Ji, X; Li, J; Liu, Y; Tan, R; Wang, H; Wang, L; Wu, Z; Zhang, Y; Zhong, X; Zhu, M, 2018) |
| "Renal interstitial fibrosis is a final pathway that is observed in various types of kidney diseases, including diabetic kidney disease (DKD)." | ( Li, Y; Liao, YJ; Luo, JH; Yin, DD; Zhao, ZY, 2018) |
| "Renal fibrosis is defined as the excessive deposition and modification of extracellular matrix (ECM) in the renal parenchyma in response to injury and inflammation, resulting in renal function loss." | ( Li, N; Ritter, JK; Zhang, X, 2018) |
| "LV myocardial fibrosis is present in many PLN p." | ( Boekholdt, SM; de Boer, RA; Gorter, TM; Planken, RN; Suurmeijer, AJH; Te Rijdt, WP; Ten Sande, JN; van den Berg, MP; van der Zwaag, PA; van Dessel, PFHM; van Haelst, PL; van Rijsingen, IA; van Tintelen, JP; van Veldhuisen, DJ; Wilde, AAM; Willems, TP, 2019) |
| "Renal fibrosis is a complication of kidney injury and associated with increased risk of morbidity and mortality." | ( Begum, J; Kumar, D; Kumar, P; Lingaraju, MC; Mathesh, K; Sharma, A; Singh, TU; Thakur, R, 2018) |
| "Tubulo-interstitial fibrosis is the final pathway in the progression of chronic kidney disease (CKD) to kidney failure." | ( Cao, G; Chen, DQ; Chen, L; Guo, Y; Liu, D; Vaziri, ND; Wang, M; Zhao, H; Zhao, YY, 2018) |
| "Radiation-induced fibrosis is a side effect of radiation therapy and may occur in up to 13% of the cases in patients (Radiother Oncol, 2009;90:80), fortunately usually is modest/localized and not associated with marked symptoms." | ( Jones, EL; Kaidar-Person, O; Marks, LB, 2018) |
| "Intestinal fibrosis is a major complication of CD and may result in stricture formation leading to intestinal obstruction." | ( He, X; Huang, Q; Ke, J; Lan, P; Lian, L; Qin, H; Xie, M; Zhang, L, 2018) |
| "Myocardial fibrosis is characterized by excessive cross-linking and deposition of collagen type I and is involved in left ventricular stiffening and left ventricular diastolic dysfunction (LVDD)." | ( Bach, D; Bachran, D; Delles, C; Díez, J; Dominiczak, AF; Edelmann, F; González, A; Hasenfuss, G; López, B; Pieske, B; Ravassa, S; Trippel, T; Wachter, R, 2018) |
| "Fibrosis is the end result of most inflammatory conditions, but its pathogenesis remains unclear." | ( Abtin, F; Divekar, AA; Furst, DE; Kafaja, S; Khanna, D; Saggar, R; Singh, RR; Valera, I, 2018) |
| "Renal fibrosis is widely considered a common mechanism leading to end-stage renal failure." | ( Cai, W; Feng, D; Luo, M; Wang, H; Xu, C; Zhou, S; Zhou, T, 2018) |
| "Renal fibrosis is a common pathological symptom of chronic kidney disease (CKD)." | ( Ding, W; Liu, Y; Wang, Y, 2018) |
| "Adipose tissue fibrosis is associated with inflammation and insulin resistance in human obesity." | ( Farmer, SR; Lin, JZ; Rabhi, N, 2018) |
| "Skeletal-muscle fibrosis is a common and irreversibly damaging process." | ( Li, JL; Li, Y; Pan, H; Qi, X; Qian, H; Rao, Z; Wang, L; Wu, G; Xu, M; Ying, H; Zhang, H, 2018) |
| "Cardiac fibrosis is a crucial factor of heart failure." | ( Feng, K; Liu, T; Liu, Y; Lu, C; Pan, Y; Tang, Y; Wang, X; Wu, Y; Xu, H, 2018) |
| "Renal fibrosis is the final manifestation of various chronic kidney diseases, and no effective therapy is available to prevent or reverse it." | ( Cao, X; He, QH; Li, GQ; Li, SJ; Li, Y; Tang, M; Xu, GL; Zhang, K; Zhang, KQ; Zheng, QY, 2018) |
| "Cardiac fibrosis is an independent risk factor for heart failure and even the leading cause of death in myocardial infarction patients." | ( Cao, Y; Jia, S; Liu, Y; Weng, L; Xu, C; Ye, J; Zheng, M, 2018) |
| "Cardiac fibrosis is implicit in all forms of heart disease but there are no effective treatments." | ( Camelliti, P; Griffin, M; Lip, GYH; Murdoch, CE; Stuckey, DJ; Wang, Z, 2018) |
| "Fibrosis is a severe health problem characterized by progressive stiffening of tissues which causes organ malfunction and failure." | ( Asmani, M; Chen, Z; Hinz, B; Hsia, I; Li, Y; Velumani, S; Wawrzyniak, N; Zhao, R, 2018) |
| "Adipose tissue fibrosis is a novel mechanism for the development of obesity related insulin resistance." | ( Hua, Y; Song, Y; Wang, L; Ye, X, 2018) |
| "Age-related fibrosis is attenuated by aerobic exercise; however, little is known concerning the underlying molecular mechanism." | ( Liu, HM; Liu, JD; Ma, N; Wang, XZ; Xia, T, 2018) |
| "Cardiac fibrosis is a common feature of many cardiac pathophysiologic conditions." | ( Qi, R; Tuerdi, N; Wan, Y; Wang, Y; Xu, L; Ye, M, 2018) |
| "Fibrosis is an inadequate response to tissue stress with very few therapeutic options to prevent its progression to organ dysfunction." | ( Aubert, JD; Golshayan, D; Juillerat-Jeanneret, L; Mikulic, J, 2018) |
| "Fibrosis is a pathophysiological state characterized by the excessive formation/deposition of fibrous extracellular matrix." | ( Adhyatmika, A; Adlia, A; de Jong, KP; Luangmonkong, T; Mutsaers, HAM; Olinga, P; Oosterhuis, D; Suriguga, S; Suthisisang, C, 2018) |
| "Fibrosis is a pathological form of aberrant tissue repair, the complications of which account for nearly half of all deaths in the industrialized world." | ( Dolivo, DM; Dominko, T; Larson, SA, 2018) |
| "Renal fibrosis is the common manifestation of CKD that usually leads to end-stage renal disease although the molecular events leading to chronic renal fibrosis and eventually chronic renal failure remain to be fully understood." | ( Chen, L; Feng, Y; Gan, H; Haydon, RC; He, TC; Huang, B; Huang, S; Lei, J; Liu, W; Luo, W; Luu, HH; Shu, Y; Wang, X; Xia, Y; Yan, S; Yu, X; Yuan, C; Zeng, L; Zeng, Z; Zhang, B; Zhang, H; Zhang, L; Zhang, R; Zhang, X; Zhao, C, 2018) |
| "Cardiac fibrosis is referred to as an excessive accumulation of stromal cells and extracellular matrix proteins in the myocardium." | ( Błyszczuk, P; Działo, E; Tkacz, K, 2018) |
| "Cardiac fibrosis is a common pathologic consequence of stress insult to the heart and is characterized by abnormal deposition of fibrotic extracellular matrix that compromises cardiac function." | ( Accornero, F; Dorn, LE; Petrosino, JM; Wright, P, 2018) |
| "Tubulointerstitial fibrosis is a common feature of kidney disease." | ( Bae, EH; Cha, H; Cho, JM; Choi, HS; Eom, GH; Joo, SY; Kim, I; Kim, IJ; Kim, SW; Ma, SK; Song, JH, 2018) |
| "Renal interstitial fibrosis is a common renal injury resulted from a variety of chronic kidney conditions and an array of factors." | ( Ding, T; Huang, M; Tang, D; Tao, L; Xu, H; Ye, Z; Yuan, Q; Zhang, J, 2018) |
| "Skin fibrosis is accompanied by attrition of the dermal white adipose tissue layer, and alterations in the levels and function of adiponectin." | ( Asano, Y; Fang, F; Hong, W; Lakota, K; Sato, S; Sodin-Semrl, S; Taniguchi, T; Varga, J; Yamashita, T; Yoshizaki, A; Zhou, X, 2018) |
| "Intestinal fibrosis is a common complication of Crohn's disease (CD)." | ( Guan, L; Li, Y; Sun, MJ; Zhang, HJ; Zhang, YN; Zhou, H, 2018) |
| "Increased fibrosis is a hallmark of the development and pathology of CTS." | ( Bali, A; Jaggi, AS; Sharma, D, 2018) |
| "Renal fibrosis is the final common pathway of numerous progressive kidney diseases, and transforming growth factor-β (TGF-β) has an important role in tissue fibrosis by up-regulating matrix protein synthesis, inhibiting matrix degradation, and altering cell-cell interaction." | ( Isaka, Y, 2018) |
| "Fibrosis is known to be the hallmarks of chronic inflammation of the bowel." | ( Kesharwani, P; McCarron, PA; Shukla, R; Tambuwala, MM; Thompson, PD, 2018) |
| "Fibrosis is a common pathological feature in most kinds of chronic kidney disease." | ( An, HJ; Gu, H; Gwon, MG; Jang, KM; Kim, JY; Park, B; Park, JH; Park, KK, 2018) |
| "Renal fibrosis is a well-known pathological stage frequently observed in progressive chronic kidney disease (CKD)." | ( Chang, YW; Singh, KP, 2019) |
| "Cardiac fibrosis is a common precursor to ventricular dysfunction and eventual heart failure, and cardiac fibrosis begins with cardiac fibroblast activation." | ( Choi, JW; Hwang, KC; Kim, IK; Kim, SW; Lee, CY; Lee, J; Lee, S; Lim, S; Seo, HH; Shin, S; Song, BW, 2019) |
| "Tissue fibrosis is one of the major problems in successfully treating chronic pancreatitis pathogenesis." | ( Kandikattu, HK; Manohar, M; Mishra, A; Verma, AK, 2018) |
| "Myocardial fibrosis is a common pathophysiological process that is related to ventricular remodeling in congenital heart disease." | ( An, Q; Chen, YC; Cheng, W; Chung, YC; Greiser, A; Han, Y; Li, X; Liu, H; Luo, Y; Sun, JY; Wan, K; Yang, D; Zhang, TJ, 2018) |
| "Increased diffuse fibrosis is associated with worse LV function, increased Ebstein's severity, and worse clinical status." | ( An, Q; Chen, YC; Cheng, W; Chung, YC; Greiser, A; Han, Y; Li, X; Liu, H; Luo, Y; Sun, JY; Wan, K; Yang, D; Zhang, TJ, 2018) |
| "Pancreatic fibrosis is a pathophysiological process associated with excessive deposition of extracellular matrix in pancreas, leading to reduced insulin secretion and derangement of glucose metabolism." | ( Huwatibieke, B; Li, Y; Li, Z; Liu, S; Yin, Y; Yu, R; Zhang, W, 2018) |
| "Intestinal fibrosis is thought to be a consequence of excessive tissue repair, and constitutes a common problem in patients with Crohn's disease (CD)." | ( Fagagnini, S; Hausmann, M; Hünerwadel, A; Jaeger, SU; Lutz, C; Mamie, C; Rogler, G; Ruiz, PA; Weder, B, 2018) |
| "Fibrosis is markedly increased in peritumoral liver." | ( Anders, RA; Besharati, S; Cottrell, TR; Waters, KM; Zhu, Q, 2019) |
| "Cardiac fibrosis is an important cardiac remodeling event in the development of inflammation dilated cardiomyopathy （iDCM）." | ( Cheng, B; Hu, F; Lu, S; Ma, W; Wang, Y; Wang, Z; Yan, L, 2018) |
| "Myocardial fibrosis is progressive in some HCM patients." | ( Ariga, R; Chan, K; Daniels, MJ; Dass, S; Francis, J; Kramer, CM; Lewandowski, AJ; Mahmod, M; Neubauer, S; Ohuma, EO; Petersen, SE; Raman, B; Rodgers, C; Sivalokanathan, S; Smillie, R; Spartera, M; Watkins, H, 2019) |
| "Cardiac fibrosis is a common pathophysiological process observed during chronic and stress-induced acceleration of cardiac aging." | ( Chang, HN; Chang, YM; Day, CH; Huang, CY; Kuo, WW; Lin, HJ; Lin, YM; Tamilselvi, S; Tsai, CC; Viswanadha, VP, 2019) |
| "Epidural fibrosis is a major problem after spine surgery, with some patients having recurrent symptoms secondary to excessive formation of scar tissue resulting in neurologic compression." | ( Borekci, A; Bozkurt, H; Eğilmez, R; Gürer, B; Kertmen, H; Kuru Bektaşoğlu, P; Öztürk, ÖÇ; Yüce, MF, 2019) |
| "Cardiac fibrosis is a major cause of diverse cardiovascular diseases." | ( Guo, L; Hao, S; Huang, C; Lang, Y; Liang, Z; Liu, H; Pei, Y; Shu, L; Su, G; Xu, J; Zhang, J, 2018) |
| "Cardiac fibrosis is defined as the imbalance of extracellular matrix (ECM) production and degradation, thus contributing to cardiac dysfunction in many cardiac pathophysiologic conditions." | ( Ma, ZG; Tang, QZ; Wu, HM; Yuan, YP; Zhang, X, 2018) |
| "Intestinal fibrosis is a long-term complication in inflammatory bowel diseases (IBD) that frequently results in functional damage, bowel obstruction, and surgery." | ( Atreya, R; Baum, P; Carlé, B; Claussen, J; Ekici, AB; Friedrich, O; Kersten, C; Klimowicz, AC; Knieling, F; Kollias, G; Mbow, ML; Meyer, S; Neufert, C; Neurath, MF; Primbs, T; Rath, T; Raymond, EL; Scheibe, K; Schmied, A; Schürmann, S; Vieth, M; Waldner, MJ; Wirtz, S; Zheng, J, 2019) |
| "Progressive renal fibrosis is the last phase of chronic kidney disease and results in renal failure." | ( Chen, B, 2019) |
| "Fibrosis is characterized by the excessive deposition of extracellular matrix and crosslinked proteins, in particular collagen and elastin, leading to tissue stiffening and disrupted organ function." | ( Buson, A; Deodhar, M; Findlay, AD; Foot, JS; Greco, A; Jarolimek, W; Joshi, A; Moses, J; Perryman, L; Rayner, B; Schilter, H; Townsend, S; Turner, CI; Yow, TT; Zahoor, A; Zhou, W, 2019) |
| "Background Cardiac fibrosis is a core pathological process associated with heart failure." | ( Deng, XL; Du, XJ; Gou, W; Hou, MC; Lai, BC; Lei, T; Ren, YJ; She, G; Wang, HF; Wang, Y, 2019) |
| "Renal fibrosis is the pathological hallmark of chronic kidney disease (CKD) and manifests as glomerulosclerosis and tubulointerstitial fibrosis." | ( Bhave, G; Colon, S; Gewin, L; Liu, Y; Luan, H; Meyer, C, 2019) |
| "Renal fibrosis is a key pathological feature and final common pathway leading to end-stage kidney failure in many chronic kidney diseases." | ( Cao, Q; Feng, X; Guo, R; Hu, M; Liu, X; Qiao, X; Wang, H; Wang, L; Wang, Y; Yang, Y; Zhang, J; Zhang, Z; Zhao, L; Zheng, G, 2019) |
| "Renal fibrosis is the common final outcome of nearly all progressive chronic kidney diseases (CKD) that eventually develop into end-stage renal failure, which threatens the lives of patients." | ( Du, J; He, Q; Jiang, L; Jin, F; Jin, Y; Luo, P; Yang, B; Zhang, Y; Zhao, Z, 2019) |
| "Fibrosis is associated with accumulation of excess fibrillar collagen, leading to tissue dysfunction." | ( Bennett, RG; Ng, HH; Samuel, CS; Schlossmann, J; Shen, M, 2019) |
| "Myocardial fibrosis is a major pathophysiologic substrate of heart failure with preserved ejection fraction." | ( Joseph, J; Joseph, L; Zhang, L, 2019) |
| "Renal fibrosis is the most common pathway leading to end-stage renal disease." | ( Dan, Z; Guanyi, L; Lan, T; Menghua, L; Wei, Z; Xianyuan, L; Xueli, T; Yaqian, D; Zhanglu, D, 2019) |
| "Cardiac fibrosis is a common feature in chronic hypertension patients with advanced heart failure, and endothelial-tomesenchymal transition (EndMT) is known to promote Angiotensin II (Ang II)-mediated cardiac fibrosis." | ( Chen, D; Fu, M; Gao, P; Grossfeld, P; Han, W; Ostrowski, MC; Xu, L; Ye, M, 2019) |
| "Excessive fibrosis is the topmost factor for the defeat of surgical glaucoma drainage device (GDD) implantation." | ( Dong, A; Fan, P; Han, L; Shao, Z; Yuan, H; Zhou, X, 2019) |
| "Renal fibrosis is the final common pathway of various renal injuries and it leads to chronic kidney disease." | ( Ha, H; Kim, HL; Kim, J; Kim, JW; Kim, WY; Kim, YK; Komatsu, M; Lee, MS; Lim, JH; Nam, SA; Park, CW; Park, SH; Yang, CW, 2019) |
| "Muscular fibrosis is caused by excessive accumulation of extracellular matrix (ECM) that replaces functional tissue, and it is a feature of several myopathies and neuropathies." | ( Brandan, E; Contreras, O; Faundez-Contreras, J; González, D; Lipson, KE; Murphy-Ullrich, JE; Rebolledo, DL; Vio, CP, 2019) |
| "Renal fibrosis is a common cause of renal dysfunction with chronic kidney diseases." | ( Armutcu, F; Celik, HT; Demircan, K; Namuslu, M; Yagmurca, M; Yildirim, U, 2019) |
| "Kidney fibrosis is one of the main pathological findings of progressive chronic kidney disease (CKD) although the pathogenesis of renal scar formation remains incompletely explained." | ( Calleros, L; de Frutos, S; García-Jérez, A; Griera, M; Hatem-Vaquero, M; Luengo, A; O'Valle, F; Rodríguez-Puyol, D; Rodríguez-Puyol, M, 2019) |
| "Atrial fibrosis is an important pathophysiological contributor to AF." | ( Dong, W; Fang, X; Guo, H; Li, H; Liang, J; Pan, R; Shan, Z; Wu, S; Xiao, Z; Yang, J; Yang, Z; Yuan, S; Zheng, XL; Zhu, J, 2019) |
| "Tubulointerstitial fibrosis is considered a hallmark of maladaptive repair processes after tubular injury leading to chronic kidney disease." | ( De Chiara, L; Romagnani, P, 2019) |
| "Renal fibrosis is the pathological feature of chronic kidney disease (CKD) which leads to end-stage renal disease (ESRD) and renal failure." | ( Bresette, W; Chen, Y; Cheng, J; Li, L; Liu, J; Liu, S; Lu, Y; Wang, C; Yuan, Y; Zhao, M; Zhou, Y, 2019) |
| "Renal fibrosis is a common histomorphological feature of renal aging and chronic kidney diseases of all etiologies, and its initiation and progression are substantially influenced by aberrant epigenetic modifications of fibrosis-susceptible genes, yet without effective therapy." | ( Bi, F; Cao, W; Chen, F; Li, Y; Lin, W; Wei, A; Yin, S; Zhu, X, 2019) |
| "Cardiac fibrosis is a pathophysiological process characterized by excessive deposition of extracellular matrix." | ( Chen, X; Cheng, L; Feng, J; Li, Q; Qiu, C; Su, J; Zheng, Q, 2019) |
| "Fibrosis is a serious health problem often leading to accompanying organ failure." | ( Faust, I; Fischer, B; Hendig, D; Knabbe, C; Kuhn, J; Ly, TD; Pécheur, EI; Reungoat, E, 2019) |
| "Renal fibrosis is the main pathological characteristic of chronic kidney disease (CKD), whereas the underlying mechanisms of renal fibrosis are not clear yet." | ( Bi, X; Han, W; He, T; Jiang, W; Li, Y; Liu, C; Liu, Y; Xiao, T; Xiong, J; Xu, X; Yang, K; Yu, Y; Zhang, B; Zhang, J; Zhao, J, 2019) |
| "Renal fibrosis is the most common final stage of progressive renal disease, characterized by fibroblast proliferation, fibroblast-to-myofibroblast differentiation and excessive accumulation of extracellular matrix." | ( Chen, X; Chen, Z; Dai, G; Du, Y; He, Y; Liu, P; Liu, Y; Mo, M; Xia, W; Zhang, B; Zhou, Y, 2019) |
| "Fibrosis is a universal finding in chronic allograft dysfunction, and it is characterized by an accumulation of extracellular matrix." | ( Ali, S; Glover, EK; Jordan, N; Sheerin, NS, 2019) |
| "Renal fibrosis is a common pathological change in all stages of kidney disease." | ( He, L; Ji, J; Tao, P, 2019) |
| "Synovial fibrosis is a pathological process that is observed in several musculoskeletal disorders and characterized by the excessive deposition of extracellular matrix, as well as cell migration and proliferation." | ( Charlier, E; de Seny, D; Deroyer, C; Gillet, P; Kurth, W; Malaise, MG; Malaise, O; Meijide-Failde, R; Neuville, S; Vaamonde-Garcia, C, 2019) |
| "Fibrosis is the common endpoint and currently the best predictor of progression of chronic kidney diseases (CKDs)." | ( Amann, K; Baues, M; Boor, P; Botnar, RM; Daniel, C; Djudjaj, S; Drude, NI; Ehling, J; Floege, J; Kiessling, F; Kim, H; Klinkhammer, BM; Kramann, R; Lammers, T; Onthank, DC; Saez-Rodriguez, J; Sun, Q; Weiskirchen, R, 2019) |
| "Fibrosis is a reparative process with very few therapeutic options to prevent its progression to organ dysfunction." | ( Huang, CY; Jiang, JL; Li, G; Zhao, WC, 2019) |
| "Renal interstitial fibrosis is a common pathological feature of chronic kidney disease that may involve changes of metabolism in kidney cells." | ( Dong, G; Dong, Z; Huo, Y; Su, J; Wei, Q; Zhang, M, 2019) |
| "Renal interstitial fibrosis is a common pathological feature in progressive kidney diseases currently lacking effective treatment." | ( Cai, J; Dong, Z; Liu, Z; Shu, S; Tang, C; Wang, Y; Zheng, M, 2019) |
| "Fibrosis is a hallmark in the pathogenesis of various diseases, with very limited therapeutic solutions." | ( Battini, T; Braga, L; Carloni, P; Celsi, F; Collesi, C; Confalonieri, M; Crovella, S; Del Sal, G; Giacca, M; Guarnaccia, C; Kocijan, T; Long, C; Marcello, A; Martinelli, V; Myers, MP; Raspa, M; Rehman, M; Ring, N; Rossetti, G; Skoko, N; Vodret, S; Vukusic, K; Zacchigna, S, 2019) |
| "Myocardial fibrosis is a common pathological manifestation of many cardiovascular diseases at the end stage." | ( He, Y; Liu, C; Liu, X; Wang, J; Wang, L; Wang, T; Wu, X; Yuan, D; Zhang, C; Zheng, J; Zhou, Z, 2019) |
| "Myocardial fibrosis is one of the serious pathological changes, so investigating the pathogenesis of myocardial fibrosis has the significant value." | ( Guanjun, Z; Heng, Z; Hongwei, Y; Jie, H; Jie, T; Junfeng, H; Qin, G; Ruiping, C; Xingyu, L; Yingyan, F; Zhenghong, L, 2019) |
| "Tubulointerstitial fibrosis is the hallmark of diabetic nephropathy, which is the leading cause of end-stage renal disease worldwide." | ( He, X; Liu, W; Wang, S; Zhang, Y; Zhao, H; Zhao, X; Zhou, Y, 2019) |
| "Myocardial fibrosis is a key pathophysiological mechanism of HFpEF and myocardial fibrotic burden is strongly and independently associated with adverse outcome." | ( Ahmed, FZ; Bedson, E; Clayton, D; Cooper, A; Cunnington, C; Dodd, S; Eccleson, H; Jimenez, BD; Lewis, GA; McDonagh, T; Miller, CA; Naish, JH; Neubauer, S; Russell, S; Schelbert, EB; Viswesvaraiah, R; Williams, SG; Williamson, PR, 2019) |
| "Fibrosis is unregulated tissue repair that may cause impairment of organ function, especially in end-organ damage." | ( Agarwal, V; Ahmed, S; Misra, DP, 2019) |
| "Fibrosis is characterized by the progressive alteration of the tissue structure due to the excessive production of extracellular matrix (ECM)." | ( Cool, RH; Michiels, T; Quax, WJ; Setroikromo, R; van Merkerk, R; Wang, Y, 2019) |
| "Myocardial fibrosis is associated with cardiovascular remodeling, which is characterized by abnormal collagen architecture." | ( Guo, Q; Jiang, Y; Liu, D; Tu, PF; Wan, YJ; Zeng, KW, 2019) |
| "Tubulointerstitial fibrosis is a final common pathway for most causes of progressive CKD." | ( Griggs, D; Rauchman, M, 2019) |
| "Cardiac fibrosis is a common pathological progress of cardiovascular disease resulting from the excessive accumulation of extracellular matrix (ECM)." | ( Guo, D; Jiao, S; Li, C; Ren, Y; Wang, Q; Wang, W; Wang, Y; Xia, K; Yang, X; Zeng, Z; Zhu, Q, 2019) |
| "Kidney fibrosis is the common histological end-point of progressive, chronic kidney diseases (CKDs) regardless of the underlying etiology." | ( Boor, P; Bülow, RD, 2019) |
| "Renal fibrosis is an important component of chronic kidney disease, an incurable pathology with increasing prevalence worldwide." | ( Chatziantoniou, C; Hadchouel, J; Prakoura, N, 2019) |
| "Renal fibrosis is a common pathological hallmark of chronic kidney disease, and no effective treatment is clinically available to manage its progression." | ( Cao, W; Chen, W; Diao, W; Guo, H; Ji, H; Wang, T; Yuan, H; Zhao, X; Zhou, H; Zhu, X, 2019) |
| "Renal fibrosis is essential for the progression of diabetic nephropathy (DN)." | ( Da, J; Dong, R; Li, J; Yu, F; Yu, J; Zha, Y, 2019) |
| "Cardiac fibrosis is a hallmark of heart failure for which there is no effective pharmacological therapy." | ( Hartmann, S; Lutz, S; Ridley, A; Santos, GL; Zimmermann, WH, 2019) |
| "Fibrosis is a highly prevalent disease, which is responsible for 45% of deaths through pathological effects in developed countries." | ( Ahn, JC; Hong, N; Kang, HW; Kim, H; Lee, Y, 2020) |
| "Fibrosis is associated with almost all forms of chronic cardiac and skeletal muscle diseases." | ( Albertini, A; Aldeiri, BM; Arnò, B; Bragg, L; Cartwright, EJ; Cossu, G; Galli, F; McDermott, JC; Miyake, T; Prehar, S; Roostalu, U, 2019) |
| "Cardiac fibrosis is a major cause of heart failure (HF), and mediated by the differentiation of cardiac fibroblasts into myofibroblasts." | ( Chen, Q; Clark, IM; Da, X; Hu, C; Li, H; Li, Y; Song, Q; Wang, QK; Yao, Y; Yu, Y, 2020) |
| "Renal fibrosis is the common pathway of chronic kidney disease progression." | ( Bae, EH; Choi, HI; Kim, CS; Kim, DH; Kim, SW; Ma, SK; Park, JS, 2019) |
| "Fibrosis is a common pathologic outcome of chronic disease resulting in the replacement of normal tissue parenchyma with a collagen-rich extracellular matrix produced by myofibroblasts." | ( Beckett, JD; Bedja, D; Butcher, JT; Chen, Y; Creamer, TJ; Dietz, HC; Gould, RA; Hata, S; Kim, DH; MacFarlane, EG; Mitzner, W; Nagpal, V; Rouf, R; Seman-Senderos, MA; Warren, DS, 2019) |
| "Renal fibrosis is the common pathological feature in a variety of chronic kidney diseases." | ( Hou, FF; Li, C; Li, H; Liu, J; Liu, Y; Luo, C; Miao, J; Niu, J; Shen, W; Yang, P; Zhang, Y; Zhou, L, 2019) |
| "The hallmark of fibrosis is an excessive accumulation of collagen, ultimately leading to organ failure." | ( Bank, RA; Piersma, B, 2019) |
| "Myocardial fibrosis is a common feature of many cardiac diseases." | ( Bikakis, I; Cunha, DK; Garcia, MJ; Greenwood, JP; Kampaktsis, PN; Karamitsos, TD; Kokkinidis, DG; Oikonomou, EK; Papanastasiou, CA, 2020) |
| "Fibrosis is a feature of EAO." | ( Bergmann, M; Bhushan, S; Fietz, D; Fijak, M; Groome, NP; Hedger, MP; Kauerhof, AC; Kliesch, S; Loveland, KA; Meinhardt, A; Nicolas, N; Pilatz, A; Schuppe, HC; Wahle, E, 2019) |
| "Fibrosis is a common pathology in renal disease." | ( Duan, Q; Huang, T; Peng, Y; Wang, X; Xia, F; Yang, T; Zhang, W; Zhou, Y, 2019) |
| "Cardiac fibrosis is a final common pathology in inherited and acquired heart diseases that causes cardiac electrical and pump failure." | ( Angelini, G; Barton, PJR; Beltrami, C; Bottolo, L; Chen, H; Cook, SA; Devapragash, N; Emanueli, C; Felkin, LE; Harmston, N; Heng, EL; Hubner, N; Lara-Pezzi, E; Mancini, M; Moreno-Moral, A; Pesce, F; Petretto, E; Pravenec, M; Rackham, OJL; Rotival, M; Schafer, S; Shkura, K; Srivastava, PK; Sun, XM; Tan, ELS; Tee, NGZ; Yu, WP, 2019) |
| "Fibrosis is characterized by hardening, overgrowth, and development of scars in various tissues as a result of faulty reparative processes, diseases, or chronic inflammation." | ( Danielson, P; Słoniecka, M, 2019) |
| "Renal fibrosis is characterized by excessive deposition of extracellular matrix (ECM) that disrupts and replaces functional parenchyma, which leads to organ failure." | ( Ma, TT; Meng, XM, 2019) |
| "Arthrofibrosis is a common complication for patients with bone fracture following external and internal fixation." | ( Dong, F; Feng, YS; Wang, MM; Xing, Y; Zhang, F, 2019) |
| "Arthrofibrosis is a common complication following total knee arthroplasty caused by pathologic fibroblast activation and excessive collagen deposition around a synovial joint leading to debilitating loss of motion." | ( Abdel, MP; Berry, DJ; Bolon, B; Carter, JM; Jay, AG; Jones, CR; Lewallen, EA; Limberg, AK; Morrey, ME; Paradise, CR; Reina, N; Robin, JX; Salib, CG; Sanchez-Sotelo, J; Tibbo, ME; Trousdale, WH; Turner, TW; van Wijnen, AJ, 2019) |
| "Epidural fibrosis is the major cause of lower back pain and other complications." | ( Chen, H; Dai, J; Jiao, R; Li, X; Sun, Y; Wan, Q; Yan, L; Zhang, X, 2019) |
| "Fibrosis is a complex pathophysiological process involving interplay between multiple cell types." | ( Chen, CW; Distler, JHW; Groeber-Becker, F; Györfi, AH; Hansmann, J; Jüngel, A; Kiesewetter, L; Li, YN; Matei, AE; Schett, G; Tran Manh, C; Trinh-Minh, T; van Kuppevelt, T; Xu, X, 2019) |
| "Fibrosis is the abnormal deposition of extracellular matrix, which can lead to organ dysfunction, morbidity, and death." | ( Kwan, JYY; Liu, FF; Liu, PP; Yip, K; Zhao, X, 2020) |
| "Fibrosis is the underlying mechanism that leads to organ dysfunction, but as yet we have no therapeutics that can influence this process." | ( Hendry, BM; Hung, G; Newbury, LJ; Sharpe, CC; Wang, JH, 2019) |
| "Fibrosis is the most important pathologic condition involved in undesirable outcomes of dacryocystorhinostomy." | ( At'kova, EL; Krakhovetskiy, NN; Rein, DA; Subbot, AM; Yartsev, VD, 2019) |
| "Tubulointerstitial fibrosis is a progressive process affecting the kidneys, causing renal failure that can be life-threatening." | ( Hashimoto, K; Hashimoto, T; Kariya, T; Koyano, T; Kumrungsee, T; Matsuyama, M; Sakurai, H; Sanada, Y; Sotomaru, Y; van de Loo, FAJ; Yanaka, N; Yazawa, N, 2019) |
| "Epidural fibrosis is an inevitable aspect of the postoperative healing process which is one of the causes of failed back surgery syndrome following spinal surgery." | ( Chen, SC; Huang, YH; Jou, IM; Kuo, YR; Lee, JS; Lin, CL; Tu, YK; Wu, CY; Yang, SC, 2019) |
| "Renal fibrosis is a progressive process resulting from a sustained injury that may ultimately cause renal failure." | ( Abdel-Rahman, N; El-Gayar, AM; El-Karef, A; Maghmomeh, AO, 2020) |
| "Cardiac fibrosis is a crucial aspect of cardiac remodeling that can severely affect cardiac function." | ( Che, Y; Jin, YG; Shen, DF; Wang, SS; Wang, ZP; Wu, QQ; Yuan, Y, 2019) |
| "The hallmark of fibrosis is tissue remodelling with excess deposition of extracellular matrix proteins (ECM), principally collagens." | ( Bartosińska, J; Krasowska, D; Wolska-Gawron, K, 2020) |
| "Cardiac fibrosis is a key feature of cardiac remodeling." | ( Chen, C; Fang, J; Guo, SB; Han, X; Li, HH; Li, PB; Lin, QY; Wang, QS; Yan, X; Zhang, YL; Zou, LX, 2019) |
| "Fibrosis is the hallmark of pathologic tissue remodelling in most chronic diseases." | ( Bank, RA; Bigaeva, E; Boersema, M; Gore, E; Kim, YO; Mutsaers, HAM; Olinga, P; Oosterhuis, D; Schuppan, D, 2020) |
| "Fibrosis is the most common pathophysiological manifestation of Chronic Kidney Disease (CKD)." | ( Boufaied, N; Feng, D; Gerarduzzi, C; Henley, N; Ngov, C, 2019) |
| "Cardiac fibrosis is a common characteristic of many cardiac diseases." | ( Feng, K; Tang, Y; Tao, R; Wei, Y; Wu, Y; Xu, H; Zhao, Y, 2020) |
| "Fibrosis is characterized by deposition of excess fibrous material in tissues and organs and is caused by aging, chronic stress, injury, or disease." | ( Ahamed, F; Arathi, BP; Desingu, PA; Jain, A; Khan, D; Kumar, S; Maity, S; Muhamed, J; Ravi, V; Sarikhani, M; Spurthi, KM; Sundaresan, NR, 2020) |
| "Spinal epidural fibrosis is commonly seen after laminectomy." | ( Akar, EA; Aker, FV; Emon, ST; Engin, T; Erdogan, B; Is, M; Sayman, E; Somay, H, 2019) |
| "Cardiac fibrosis is a critical process that impairs heart function." | ( Nie, W; Shi, K; Xie, D; Yu, B; Yu, M; Zhang, H, 2020) |
| "Fibrosis is a common pathologic pathway of progressive kidney disease involving complex signaling networks." | ( Cai, J; Chen, G; Cheng, J; Dong, Z; Hu, X; Huang, X; Liu, F; Liu, H; Liu, Y; Liu, Z; Shu, S; Sun, L; Tang, C; Zheng, M, 2020) |
| "Renal fibrosis is the main feature of late stage LN, and novel therapeutic agents are still needed." | ( Chang, Q; Chen, C; Fu, J; Illei, GG; Jiao, C; Kong, W; Kopp, JB; Li, D; Luan, J; Pi, J; Wang, Y; Zhang, Y; Zhou, H, 2019) |
| "Renal fibrosis is the most common manifestation of chronic kidney disease (CKD)." | ( Huang, L; Peng, ZZ; Qin, J; Tang, WB; Tao, LJ; Tu, JK; Wang, W; Wang, Y; Xiao, XC; Xie, YY; Xing, QQ; Xu, H; Yuan, QJ; Yuan, XN, 2019) |
| "Left atrial (LA) fibrosis is thought to be a substrate for atrial fibrillation (AF) and can be quantified by late gadolinium enhancement magnetic resonance imaging (LGE-MRI)." | ( Baher, A; Chelu, MG; Csecs, I; Goldooz, M; Kheirkhahan, M; Kholmovski, EG; Marrouche, NF; Morris, AK; Wilson, BD, 2020) |
| "Renal interstitial fibrosis is a common pathway through which chronic kidney disease progresses to end-stage renal disease." | ( Cheng, N; Li, Y; Liu, J; Luo, J; Ren, D; Xin, H; Yang, J; Zhang, J; Zhang, X, 2020) |
| "Renal fibrosis is a common pathological manifestation of almost all forms of kidney disease irrespective of the etiological cause." | ( Godugu, C; Saifi, MA, 2020) |
| "Renal fibrosis is a common feature of all progressive chronic kidney diseases." | ( Jin, J; Kang, KP; Kim, W; Park, SK; Park, W; Quan, Y, 2020) |
| "Intestinal fibrosis is a hallmark of Crohn's disease." | ( Iswandana, R; Jansen, YJM; Luangmonkong, T; Mutsaers, HAM; Olinga, P; Oosterhuis, D; Pham, BT; Suriguga, S; van Wijk, LA, 2020) |
| "Tubulointerstitial fibrosis is a major pathological hallmark of diabetic nephropathy." | ( Chang, PJ; Ho, C; Hsu, YC; Li, YC; Lin, CL; Ni, WC; Shih, YH; Shoyama, Y; Tung, CW; Uto, T, 2020) |
| "Myocardial fibrosis is a hallmark of cardiac remodeling and functionally involved in heart failure development, a leading cause of deaths worldwide." | ( Alexander, KM; Bähre, H; Bär, C; Batkai, S; Beaumont, J; Bock, K; Braesen, JH; Brandenberger, C; Dangwal, S; Diez, J; Do, QT; Fiedler, J; Fisch, S; Foinquinos, A; Geffers, R; González, A; Grote-Levi, L; Hobuß, L; Janssen-Peters, H; José, GS; Jung, M; Just, A; Kaever, V; Kenneweg, F; Kleemiss, F; Kreutzer, FP; Leonardy, J; Liao, R; López, B; Müller, DN; Ngoy, S; Pfanne, A; Piccoli, MT; Ravassa, S; Remke, J; Samolovac, S; Santer, L; Scherf, K; Schimmel, K; Schmitz, J; Thum, T; Wertheim, BM; Wilck, N; Xiao, K; Zimmer, K, 2020) |
| "Renal fibrosis is a common characteristic of chronic kidney disease (CKD), and it can lead to end-stage renal disease." | ( Ma, Z; Wang, H; Wei, X; Zang, W, 2020) |
| "Interstitial fibrosis is a histopathological hallmark of hypertrophic cardiomyopathy (HCM)." | ( Asselin, CY; Bews, H; Cheung, D; Czubryt, MP; Goyal, V; Jassal, DS; Kirkpatrick, IDC; Mittal, I; Nagalingam, RS; Zhu, A, 2020) |
| "Renal fibrosis is an inevitable course of all kinds of progressive chronic kidney disease (CKD)." | ( He, J; Tan, N; Tian, F; Wang, Z; Zhang, Z, 2020) |
| "Atrial fibrosis is a hallmark of structural remodeling in atrial fibrillation (AF)." | ( Song, W; Su, L; Yao, Y, 2020) |
| "Fibrosis is a key pathological event during muscle aging that accelerates the development of sarcopenia." | ( Chen, JL; Chen, QN; Fan, Z; Guo, A; Lyu, AK; Wu, J; Xiao, Q; Yang, YF, 2020) |
| "Tissue fibrosis is driven by myofibroblasts, that are known to maintain their phenotype in vitro, which is associated with epigenetically driven trimethylation of lysine 27 of histone 3 (H3K27me3)." | ( Abignano, G; Chang, HY; Del Galdo, F; Feghali-Bostwick, CA; Hermes, H; Jimenez, SA; Malaab, M; Ross, RL; Wasson, CW, 2020) |
| "Tissue fibrosis is a pathological condition characterized by uncontrolled fibroblast activation that ultimately leads to organ failure." | ( Bauer, Y; Birker-Robaczewska, M; Boucher, M; Freti, D; Gatfield, J; Klenk, A; Menyhart, K; Nayler, O; Renault, B; Schnoebelen, M; Studer, R; Zmajkovicova, K, 2020) |
| "Myocardial fibrosis is an endogenous response to different cardiac insults that may become maladaptive over time and contribute to the onset and progression of heart failure (HF)." | ( Adamo, L; Aimo, A; Barison, A; Bartolucci, G; Biagini, S; Cerbai, E; Emdin, M; Lo Surdo, G; Passino, C, 2020) |
| "Renal fibrosis is a hallmark of progressive chronic kidney disease." | ( Aires, RS; Cabral, EV; Farias, JS; Lima, NKS; Paixão, AD; Santos, KM; Veras, AC; Vieira, LD, 2020) |
| "Renal fibrosis is the common pathological feature in various types of CKD." | ( Feng, Q; Feng, Y; Hou, FF; Liu, Y; Miao, J; Shen, W; Wu, Q; Zhou, L; Zhou, S, 2020) |
| "Cardiac fibrosis is associated with non-ischemic dilated cardiomyopathy, increasing its morbidity and mortality." | ( Agoston-Coldea, L; Cojan-Minzat, BO; Zlibut, A, 2021) |
| "Renal fibrosis is a major contributor to the development and progression of chronic kidney disease." | ( Ellis, CL; Hassounah, F; Klein, JD; Kuma, A; Rianto, F; Rodriguez, EL; Sands, JM; Wang, XH, 2020) |
| "Renal fibrosis is a common pathway leading to the progression of chronic kidney disease." | ( Lei, Y; Li, N; Li, Z; Liu, X; Sun, T; Wang, Z, 2020) |
| "Renal fibrosis is a key factor in chronic kidney disease (CKD)." | ( Chen, X; Chen, Z; Du, Y; He, Y; Liu, P; Liu, Y; Zhang, B, 2020) |
| "Renal fibrosis is a hallmark of chronic kidney disease." | ( Gu, YY; Huang, XR; Lan, HY; Liu, XS; Yu, XQ, 2020) |
| "Fibrosis is a complication of tendon injury where excessive scar tissue accumulates in and around the injured tissue, leading to painful and restricted joint motion." | ( Atluri, K; Chinnathambi, S; Martin, JA; Mendenhall, A; Salem, AK; Sander, EA, 2020) |
| "Fibrosis is a final common pathway for many causes of progressive chronic kidney disease (CKD)." | ( Basta, J; Griggs, DW; Prinsen, MJ; Rauchman, M; Robbins, L; Stout, L, 2020) |
| "Fibrosis is a fundamental feature of systemic sclerosis (SSc) and is characterized by excessive accumulation of extracellular matrix components like proteoglycans (PG) or collagens in skin and internal organs." | ( Faust, I; Fischer, B; Hendig, D; Knabbe, C; Kuhn, J; Ly, TD; Plümers, R; Schmidt, V, 2020) |
| "Myocardial fibrosis is often associated with cardiac hypertrophy; indeed, fibrosis is one of the most critical factors affecting prognosis." | ( Akaike, T; Kuga, K; Kusakari, Y; Minamisawa, S; Semba, K; Uesugi, K; Urashima, T, 2020) |
| "Kidney fibrosis is a highly deleterious process and a final manifestation of chronic kidney disease." | ( Bozic, M; Caus, M; Fernández, E; Gallel, P; Garí, E; Martinez, A; Panadés, MJ; Pedraza, N; Rodrigues-Diez, RR; Ruiz-Ortega, M; Valdivielso, JM, 2020) |
| "Fibrosis is characterized by excessive deposition of extracellular matrix components such as collagen in tissues or organs." | ( AlQudah, M; Czubryt, MP; Hale, TM, 2020) |
| "Conjunctival fibrosis is a process of extracellular matrix accumulation and the appearance of myofibroblasts in subconjunctival fibroblasts induced by injury or inflammation, which can significantly reduce the filtration efficiency of glaucoma filtration surgery." | ( Chen, L; Fu, Y; Lu, Y; Shao, C; Sun, H; Wu, N; Yan, D; Yao, Q; Zhou, M, 2020) |
| "Renal fibrosis is a kind of progressive kidney disease leading to end-stage renal damage." | ( Chen, J; He, Y; Li, J; Liu, B; Lu, R; Pang, Y; Wu, J; Zhou, J; Zhou, Y, 2020) |
| "Renal fibrosis is the typical manifestation of progressive kidney disease and causes a severe threat to human health." | ( Bao, H; Chen, W; Li, J; Li, P; Li, Q; Liu, X; Yang, X; Zhang, K, 2020) |
| "Subendocardial fibrosis is recognized finding in left ventricular noncompaction (LVNC); however, the evidence regarding the patterns and the frequency of late gadolinium enhancement (LGE) on cardiac magnetic resonance imaging (CMRI) is controversial." | ( Alis, D; Asmakutlu, O; Sahin, A; Topel, C, 2020) |
| "Cardiac fibrosis is a pathological feature common to a variety of heart diseases such as myocardial infarction, arrhythmias, cardiomyopathies and heart failure." | ( Han, F; Jin, D, 2020) |
| "Renal fibrosis is a major pathological event in the development of diabetic nephropathy (DN)." | ( Liang, R; Wang, P; Xu, L; Yang, C; Zhang, S, 2020) |
| "Fibrosis is the formation of excess connective tissue in an organ or tissue during a reparative or reactive process." | ( Baek, JA; Cho, KH; Cho, ML; Choi, JW; Choi, JY; Jhun, J; Kim, SY; Park, MJ; Park, SH; Ryu, J, 2020) |
| "Renal fibrosis is common to all forms of progressive kidney disease." | ( Cao, Q; Chen, J; Chen, X; Huang, C; Pollock, C; Shi, Y; Yi, H; Zhao, Y, 2020) |
| "Cardiac fibrosis is a reparative process after myocardial infarction (MI), which leads to cardiac remodeling and finally heart failure." | ( Chen, J; Ge, J; Jia, J; Li, B; Ma, L; Qian, J; Qin, Q, 2021) |
| "Fibrosis is a major cause of loss of renal function in autosomal dominant polycystic kidney disease (ADPKD)." | ( Calvet, JP; Dwivedi, N; Fields, TA; Howard, C; Jamadar, A; Leask, A; Rao, R; Sinha, S; Tao, S; Wallace, DP, 2020) |
| "Fibrosis is the most characteristic pathological hallmark of SSc, a connective tissue disease characterized by vascular and immunological abnormalities, inflammation and enhanced extracellular matrix production, leading to progressive fibrosis of skin and internal organs." | ( Arvia, R; Del Rosso, M; Ferri, C; Fibbi, G; Gallinella, G; Laurenzana, A; Margheri, F; Stincarelli, MA; Zakrzewska, K, 2020) |
| "Renal fibrosis is a progressive pathological process that eventually leads to end-stage renal failure with limited therapeutic options." | ( He, D; Hu, D; Lin, T; Liu, B; Liu, X; Long, C; Shen, L; Wei, G; Xiang, H; Xu, T; Yu, Y; Zhang, D; Zhang, Y; Zhou, Y, 2020) |
| "Renal fibrosis is a major factor in the progression of chronic kidney disease and the final common pathway of kidney injury." | ( Bi, J; Fujimura, R; Fukagawa, M; Imafuku, T; Katsuki, H; Kurauchi, Y; Maeda, H; Maruyama, T; Matsushita, K; Mukunoki, A; Murata, R; Nakagata, N; Nakamura, Y; Nishida, K; Takeo, T; Tanaka, M; Watanabe, H, 2020) |
| "Fibrosis is the final common pathway to intestinal failure in Crohn's disease, but no medical therapies exist to treat intestinal fibrosis." | ( Berinstein, JA; Cushing, KC; Higgins, PDR; Huang, S; Johnson, LA; Rodansky, ES; Spence, JR; Steiner, CA, 2021) |
| "Myocardial fibrosis is a major complication of diabetic cardiomyopathy (DCM) that is primarily caused by cardiac fibroblasts that are highly activated by persistent hyperglycemic stimulation, resulting in excessive collagen deposition." | ( Li, L; Liu, Y; Wang, Q; Wang, Z; Xu, J; Xu, X; Yu, Y; Yuan, H; Zhou, B; Zhu, Y, 2020) |
| "Myocardial fibrosis is well-known to be the aberrant deposition of extracellular matrix (ECM), which may cause cardiac dysfunction, morbidity, and death." | ( Chen, Y; Meng, Q; Sun, D; Yao, X; Zhan, K; Zhang, X; Zhao, Y; Zhu, L, 2020) |
| "Reducing fibrosis is a potential therapeutic target; however, its effect on muscle regeneration is not fully understood." | ( Blemker, SS; Ghajar-Rahimi, E; Jones, BK; Martin, KS; Miller, EY; Peirce, SM; Virgilio, KM, 2021) |
| "Pulmonary fibrosis is a disease in which lung tissues become fibrous and thereby causes severe respiratory disturbances." | ( Kang, MK; Kang, YH; Kim, DY; Kim, SI; Kim, YH; Lee, EJ; Na, W; Oh, H; Oh, SY, 2020) |
| "Myocardial fibrosis is observed in multiple cardiac conditions including hypertension and aortic stenosis." | ( Baker, AH; Borthwick, G; Boswell, L; Dweck, MR; Gray, GA; Jansen, MA; Kwiecinski, J; Lennen, RJ; Newby, DE, 2020) |
| "Kidney fibrosis is a common final pathway of chronic kidney diseases, which are characterized by renal architecture damage, inflammation, fibroblast expansion and myofibroblast formation." | ( Anggorowati, N; Arfian, N; Emoto, N; Hartopo, AB; Nugrahaningsih, DAA; Suzuki, Y, 2020) |
| "Diabetic cardiac fibrosis is one of the main pathological manifestations of diabetic cardiomyopathy (DCM)." | ( Ding, XS; Shi, P; Tao, H; Xuan, HY, 2020) |
| "Liver fibrosis is characterized by the transdifferentiation of hepatic stellate cells (HSCs) to myofibroblasts and poor response to treatment." | ( Fang, CH; Guo, CJ; Li, H; Pan, Q; Wang, JZ; Xu, QY, 2020) |
| "Intestinal fibrosis is a common complication of inflammatory bowel disease (IBD) and is defined as an excessive accumulation of scar tissue in the intestinal wall." | ( Appendino, G; Calzado, MA; Collado, JA; García-Martín, A; Minassi, A; Muñoz, E; Palomares, B; Prados, ME; Unciti-Broceta, JD, 2021) |
| "Renal fibrosis is common especially in the elderly population." | ( Chen, YH; Luo, B; Wang, H; Xie, DD; Xing, WY; Xu, DX; Xu, S; Zhang, C; Zhang, ZC; Zhang, ZH, 2021) |
| "Cardiac fibrosis is a typical pathological change in various cardiovascular diseases." | ( Bi, XY; Ding, YQ; Wang, PX; Ye, JT; Yu, YH; Yuan, J; Zhang, LL; Zhang, YH; Zhou, H, 2021) |
| "Cardiac fibrosis is a key physiological response to cardiac tissue injury to protect the heart from wall rupture." | ( Anastasia, L; Aureli, M; Carsana, EV; Ciconte, G; Cirillo, F; Creo, P; D'Imperio, S; Garatti, A; Ghiroldi, A; Menicanti, L; Micaglio, E; Monasky, MM; Pappone, C; Piccoli, M; Rota, P, 2020) |
| "Fibrosis is a pathological feature of chronic kidney disease and its progression correlates with declining renal function." | ( Ding, C; Ding, X; Ricardo, S; Shen, HH; Tesch, G; Tian, P; Wang, B; Xue, W; Zheng, J, 2020) |
| "Cardiac fibrosis is a major pathological manifestation of diabetic cardiomyopathy, which is a leading cause of mortality in patients with diabetes." | ( Duan, JZ; He, Q; Li, Y; Wang, CQ, 2020) |
| "Renal fibrosis is a common pathological hallmark of chronic kidney disease (CKD)." | ( Hou, Y; Liu, N; Ren, H; Shang, W; Yin, Z; Zuo, S, 2020) |
| "Renal fibrosis is a frequently occurring type of chronic kidney disease that can cause end-stage renal disease." | ( Chen, M; Deng, L; Hu, Y; Li, J; Liu, Y; Yang, F; Zhong, W, 2020) |
| "TGF-β-driven fibrosis is mediated through Smad-dependent or non-Smad pathways and is modulated by coreceptors and by interacting networks." | ( Frangogiannis, N, 2020) |
| "Fibrosis is a condition shared by numerous inflammatory diseases." | ( Angiolilli, C; Bekker, CPJ; Boes, M; Cossu, M; de Boer, RJ; Devaprasad, A; Giovannone, B; Hack, E; Lopes, AP; Marut, W; Pandit, A; Radstake, TRDJ; Silva-Cardoso, SC; Tao, W; van Laar, J, 2020) |
| "Vocal fold fibrosis is an abnormal condition characterized by unfavorable changes in the organization of the extracellular matrix in vocal fold lamina propria." | ( Hwang, CW; Jung, WK; Kim, TH; Lee, HS; Oh, SJ, 2020) |
| "Myocardial fibrosis is a major determinant of clinical outcomes in heart failure (HF) patients." | ( Ali, S; Bouchareb, R; Katz, M; Lebeche, D; Saadallah, N; Sassi, Y, 2020) |
| "Cardiac fibrosis is associated with most of heart diseases, but its molecular mechanism remains unclear." | ( Chang, Y; Guo, Z; Ma, K; Si, J; Sun, C; Tian, X; Wang, X, 2020) |
| "Kidney fibrosis is a histological hallmark of chronic kidney disease (CKD) and is believed to be involved in the progression of CKD." | ( Asai, A; Makitani, K; Ogo, N, 2020) |
| "Renal fibrosis is one of the main causes of chronic kidney disease." | ( Go, G; Lee, SH; Lim, JH; Yoon, YM; Yun, CW, 2020) |
| "Renal fibrosis is a common pathological process in the progression of chronic kidney disease." | ( Cheng, Y; Ge, S; Li, L; Luo, R; Xu, G; Yang, Y, 2020) |
| "Fibrosis is the end stage of many chronic diseases, which results in organ function failure and high mortality." | ( Fan, S; Huang, C; Zhang, L, 2021) |
| "Renal fibrosis is a frequent axis contributing to the occurrence of end-stage nephropathy." | ( Bai, Y; Chen, C; Guo, H; Guo, Y; Shentu, Y; Xiao, Y; Zheng, C; Zhou, Y; Zhu, H, 2021) |
| "Myocardial fibrosis is a hallmark of atrial fibrillation (AF) and its characterization could be used to guide ablation procedures." | ( Alarcón, F; Althoff, TF; Arbelo, E; Benito, EM; Borràs, R; Caixal, G; Cozzari, J; Garre, P; Guasch, E; Gunturitz, C; Linhart, M; Mont, L; Nuñez-Garcia, M; Perea, RJ; Prat-González, S; Roca-Luque, I; Sitges, M; Soto-Iglesias, D; Tolosana, JM, 2021) |
| "Cardiac fibrosis is characterized by accumulation and activation of fibroblasts and excessive production of extracellular matrix, which results in myocardial stiffening and eventually leads to heart failure." | ( Karhu, ST; Ruskoaho, H; Talman, V, 2021) |
| "Radiation-induced fibrosis is a long-term adverse effect of external beam radiation therapy for cancer treatment that can cause pain, loss of function, and decreased quality of life." | ( El Abiad, JM; Gans, I; James, AW; Levin, AS; Morris, CD, 2021) |
| "Fibrosis is characterized by the excessive accumulation of extracellular matrix components, leading to loss of tissue function in affected organs." | ( Bernacchioni, C; Bruni, P; Cencetti, F; Donati, C; Vannuzzi, V, 2021) |
| "Fibrosis is presented in various physiologic and pathologic conditions of the salivary gland." | ( Cho, ES; Han, D; Kim, HS; Yook, JI; Yun, JS; Zhang, X, 2020) |
| "Tubulointerstitial fibrosis is a hallmark of diabetic nephropathy and is associated with an epithelial-to-mesenchymal transition (EMT) program and aberrant glycolysis." | ( Kanasaki, K; Koya, D; Kumagai, A; Liu, H; Takagaki, Y, 2021) |
| "Renal fibrosis is a final common manifestation of CKD resulting in progressive loss of kidney function." | ( Fu, P; Guo, F; Huang, R; Li, Y; Ma, L, 2021) |
| "Renal fibrosis is a potent predictor of progression in patients and is often accompanied by inflammation and oxidative stress; however, the mechanisms involved in these alterations are not well established." | ( Cachofeiro, V; de la Fuente-Chávez, L; Delgado-Valero, B; Islas, F; Luaces, M; Martínez-Martínez, E; Ramchandani, B; Romero-Miranda, A; Visitación Bartolomé, M, 2021) |
| "Myocardial fibrosis is a remarkably dynamic process mediated by different molecular pathways that represent potential targets of novel therapeutic interventions." | ( Di Maio, S; Falasconi, G; Fiore, G; Fragasso, G; Margonato, A; Preda, A; Slavich, M; Spoladore, R, 2021) |
| "Renal fibrosis is a major cause of renal failure in diabetic nephropathy." | ( Habibi, P; Naderi, R; Nikibakhsh, AA; Pourheydar, B; Samadi, M, 2021) |
| "Fibrosis is a process characterized by an excessive accumulation of the extracellular matrix as a response to different types of tissue injuries, which leads to organ dysfunction." | ( Alonso-Montes, C; Cannata, P; Cannata-Andía, JB; Carrillo-López, N; Fernández-Martín, JL; Martín-Carro, B; Martínez-Arias, L; Naves-Díaz, M; Panizo, S, 2021) |
| "Renal fibrosis is one of the most significant pathological changes after ureteral obstruction." | ( Deng, Z; Diao, H; Li, S; Song, J; Sun, M; Xu, Y; Yao, F; Zhou, W, 2021) |
| "Fibrosis is a hallmark of adverse cardiac remodeling, which promotes heart failure, but it is also an essential repair mechanism to prevent cardiac rupture, signifying the importance of appropriate regulation of this process." | ( Christoffels, VM; Creemers, EE; de Vries, CJM; de Waard, V; Heese, H; Hooijkaas, IB; Medzikovic, L; van Loenen, PB; van Roomen, CPAA, 2021) |
| "Cardiac fibrosis is a significant component of pathological heart remodeling, yet it is not directly targeted by existing drugs." | ( Chandrabhatla, AS; Christiansen, SL; Holmes, JW; Nelson, AR; Saucerman, JJ; Zeigler, AC, 2021) |
| "Cardiac fibrosis is one of the most often pathological changes of heart tissues." | ( Hallajzadeh, J; Mirsafaei, L; Reiner, Ž; Zivarpour, P, 2022) |
| "Fibrosis is a serious disease that occurs in many organs, such as kidney, liver and lung." | ( Ding, Z; Li, X; Lin, K; Wu, Z; Xu, Y; Yao, H, 2021) |
| "Pulmonary fibrosis is a kind of inflammatory disease with end-stage lung pathological changes." | ( Han, B; Huang, W; Li, X; Peng, C; Xie, X; Ye, C; Zhang, N; Zhao, Q; Zhu, HP, 2021) |
| "Cardiac fibrosis is a pathological hallmark of progressive heart diseases currently lacking effective treatment." | ( Li, B; Li, J; Lin, Q; Liu, N; Liu, Q; Tu, T; Wu, K; Xiao, Y; Xu, W; Zhang, B; Zuo, W, 2021) |
| "Kidney fibrosis is characterized by the development of myofibroblasts originating from resident kidney and immigrating cells." | ( Broeker, KAE; Burzlaff, N; Fuchs, MAA; Kurtz, A; Schrankl, J; Wagner, C; Willam, C, 2021) |
| "Fibrosis is a pathological condition that leads to excessive deposition of collagen and increased tissue stiffness." | ( Chen, Z; Khuu, N; Kumacheva, E; Prince, E, 2021) |
| "In addition, kidney fibrosis is a key pathogenic intermediate for the progression of CDK." | ( Gao, Y; Kong, L; Sun, X; Tan, Y; Wang, S; Wang, T; Wu, X; Xu, Q; Xu, Y; Ye, J; Yuan, M; Zheng, B, 2021) |
| "Renal fibrosis is the common pathological hallmark of chronic kidney disease, and SET domain containing lysine methyltransferase 7 (SETD7) promote considerably renal fibrosis." | ( Huang, J; Liang, H; Liang, Z; Liu, B; Nie, J; Wen, S; Yu, W, 2021) |
| "Fibrosis is characterized by dysregulation and accumulation of extracellular matrix." | ( Gelbard, MK; Rosenbloom, J, 2021) |
| "Myocardial fibrosis is caused by the adverse and powerful remodeling of the heart secondary to the death of cardiomyocytes after myocardial infarction." | ( Du, Z; Fan, Z; Guo, J; Hang, P; Li, W; Sun, Y; Yu, J; Zhao, X, 2021) |
| "Renal fibrosis is the final result of the progression of chronic kidney disease (CKD) to end-stage renal disease (ESRD)." | ( Chen, Y; Han, X; Li, F; Li, H; Lin, T; Liu, G; Tao, J; Zhang, Y; Zhao, Z, 2022) |
| "Cardiac fibrosis is the most important pathogenesis leading to cardiac remodeling and heart failure after myocardial infarction (MI)." | ( Chang, G; Cheng, X; Gao, L; Li, G; Qin, S; Wang, L; Wen, X; Zhang, D, 2021) |
| "Left atrial (LA) fibrosis is present in patients with atrial fibrillation (AF) and can be visualized by magnetic resonance imaging with late gadolinium enhancement (LGE-MRI)." | ( Alarcón, F; Althoff, T; Arbelo, E; Benito, EM; Borras, R; Brugada, J; Caixal, G; Garre, P; Guasch, E; Gunturiz, C; Mont, L; NuñezGarcia, M; Olivas, D; Perea, RJ; Prat-González, S; Roca-Luque, I; Sanchez, P; Sitges, M; Tolosana, JM, 2021) |
| "Renal fibrosis is the main pathological feature of DN." | ( Chen, L; Hu, B; Liu, C; Wang, H; Wu, J, 2021) |
| "Fibrosis is a physiological response to organ injury and is characterized by the excessive deposition of connective tissue components in an organ, which results in the disruption of physiological architecture and organ remodeling, ultimately leading to organ failure and death." | ( Guo, M; Liu, J; Long, Y; Tan, X; Wan, S; Wu, M; Xu, H; Xu, Y, 2021) |
| "Cardiac fibrosis is the final event of heart failure and is associated with almost all forms of cardiovascular disease." | ( Jin, Y; Liu, J; Wang, B; Zhang, J; Zuo, S, 2021) |
| "Cardiac fibrosis is a pathological process that presents a continuous overproduction of extracellular matrix (ECM) components in the myocardium, which negatively influences the progression of many cardiac diseases." | ( Algeciras, L; Maestro, D; Palanca, A; RuizdelRio, J; Villar, AV, 2021) |
| "Myelofibrosis (myelofibrosis) is a deadly blood neoplasia with the worst prognosis among myeloproliferative neoplasms (MPN)." | ( Dutta, A; Le, BT; Mohi, G; Nath, D; Yang, Y, 2021) |
| "Fibrosis is defined by excessive formation and accumulation of extracellular matrix proteins, produced by myofibroblasts, that supersedes normal wound healing responses to injury and results in progressive architectural remodelling." | ( Adhyatmika, A; Habibie, H; Melgert, BN; Schaafsma, D, 2021) |
| "Fibrosis is characterized by the deposition of extracellular matrix (ECM) proteins, while idiopathic pulmonary fibrosis (IPF) is a chronic respiratory disease characterized by dysregulated tissue repair and remodeling." | ( Kai, Y; Kimura, H; Muro, S; Yoneyama, H; Yoshikawa, M, 2021) |
| "Cardiac fibrosis is the hallmark of atrial remodeling in atrial fibrillation." | ( Angelov, A; Bocheva, Y; Chervenkov, T; Kisheva, A; Yotov, Y, 2021) |
| "Myocardial fibrosis is a multistep process, which results in collagen deposition in the injured muscle." | ( Atar, S; Bandel, N; Daud, E; Ertracht, O; Moady, G; Reuveni, T; Shehadeh, M, 2021) |
| "Intestinal fibrosis is a frequent complication in inflammatory bowel diseases (IBD)." | ( Amamou, A; Aziz, M; Goichon, A; Guérin, C; Marion-Letellier, R; Rouland, M; Savoye, G; Yaker, L, 2021) |
| "Intestinal fibrosis is a common complication of Crohn’s disease, yet no effective therapies exist to treat fibrostenotic disease." | ( Collins, SG; Eaton, KA; Higgins, PDR; Huang, S; Johnson, LA; Malamet, B; Rodansky, ES; Spence, JR; Steiner, CA; Tran, A, 2022) |
| "Arthrofibrosis is a debilitating complication after total knee arthroplasty (TKA) which becomes a considerable burden for both patients and clinical practitioners." | ( Chen, X; Chu, M; Deng, W; Huang, Y; Wang, Z; Zhou, Y, 2021) |
| "Renal interstitial fibrosis is characterized by the development of myofibroblasts, originating from resident renal and immigrating cells." | ( Broeker, KAE; Fuchs, MAA; Neder, TH; Schrankl, J; Wagner, C, 2021) |
| "Skin fibrosis is a complex biological remodeling process occurring in disease like systemic sclerosis, morphea, or eosinophilic fasciitis." | ( Günther, C; Hoffmann, M; Kant, TA; Klapproth, E; Künzel, K; Künzel, SR; Newe, M; Rausch, JSE; Winter, L, 2021) |
| "Kidney fibrosis is a common manifestation and hallmark of a wide variety of chronic kidney disease (CKD) that appears in different morphological patterns, suggesting distinct pathogenic causes." | ( Hakroush, S; Korsten, P; Schridde, L; Ströbel, P; Tampe, B; Tampe, D; Zeisberg, M, 2021) |
| "Cardiac fibrosis is associated with both pathological conditions." | ( Alexander, ST; Ason, B; Fordstrom, P; Ge, H; Li, CM; Liu, G; Ly, K; Rajamani, S; Shkumatov, AA; Tao, C; Yamawaki, TM; Zhou, M, 2021) |
| "Renal fibrosis is a common pathological process that occurs with diverse etiologies in chronic kidney disease." | ( Chen, X; Chen, Z; Dai, G; Gan, Y; He, Y; Li, B; Ru, F; Xia, W; Zhang, B, 2021) |
| "Kidney fibrosis is a histological hallmark of chronic kidney disease (CKD), where hyperuricemia is a key independent risk factor." | ( Fu, P; Guo, F; Ma, L; Pan, J; Shi, M, 2021) |
| "Renal fibrosis is the main pathological feature of the occurrence and development of chronic nephropathy." | ( Chen, X; Dai, Y; Gong, Q; Jin, J; Jin, R; Kan, M; Liu, Q; Yang, J; Zang, H, 2021) |
| "Fibrosis is an important factor and process of ligamentum flavum hypertrophy." | ( Chen, Y; Fan, J; Guo, Q; Meng, D; Song, G; Wu, L; Xu, G; Xu, L; Xu, P, 2021) |
| "Right atrial fibrosis is associated with the presence of atrial arrhythmias in ASD patients." | ( Chiribiri, A; Frigiola, A; Mukherjee, RK; Niederer, S; O'Hare, D; O'Neill, L; O'Neill, MD; Razeghi, O; Sim, I; Whitaker, J; Williams, SE; Wright, M, 2022) |
| "Renal fibrosis is the common pathway in chronic kidney diseases progression to end-stage renal disease, but to date, no clinical drug for its treatment is approved." | ( He, J; Huang, C; Huang, H; Jing, X; Li, J; Li, Y; Liu, Q; Tang, Q; Xia, Y; Xu, Y; Yan, J; Zhang, G; Zhang, J; Zhang, T; Zhang, Z; Zhao, Y; Zhou, J, 2021) |
| "Although renal fibrosis is a common complication of chronic kidney disease (CKD), effective options for its treatment are currently limited." | ( Chen, X; Jin, R; Kan, M; Liu, Q; Meng, X; Pu, T; Xing, T; Yang, J; Yang, Y; Zang, H, 2021) |
| "Myocardial fibrosis is an important pathological phenomenon of cardiac remodeling that is induced by hypertension, myocardial ischemia, valvular heart disease, hypertrophic cardiomyopathy, and other heart diseases and can progress to heart failure." | ( Chen, X; Ding, L; Li, H; Liang, Y; Xu, Y, 2021) |
| "Fibrosis is defined as the pathological progress of excessive extracellular matrix (ECM), such as collagen, fibronectin, and elastin deposition, as the regenerative capacity of cells cannot satisfy the dynamic repair of chronic damage." | ( Cao, Y; Chen, Y; Jiang, F; Kong, G; Li, Y; Liu, L; Tang, M; Wang, Q; Yuan, S; Zhang, Q, 2021) |
| "Myocardial fibrosis is a common feature of several heart diseases." | ( Aimo, A; Bayes-Genis, A; Emdin, M; Lupón, J; Panichella, G; Spitaleri, G, 2022) |
| "Hepatic fibrosis is the final pathway of chronic liver disease characterized by excessive accumulation of extracellular matrix (ECM), which eventually develop into cirrhosis and liver cancer." | ( Chen, Y; Li, Y; Lin, L; Que, R; Zhang, N; Zhou, M, 2021) |
| "Fibrosis is an abnormal healing process that only repairs the structure of an organ after injury and does not address damaged functions." | ( Dai, Y; Huang, Y; Lin, H; Liu, T; Wang, X, 2021) |
| "A driver of fibrosis is the kynurenine (Kyn) pathway, and Kyn metabolism patterns and cytokines may influence cGVHD severity and manifestation (fibrosing versus gastrointestinal [GI] cGVHD)." | ( Di Pasquale, P; Dischinger, K; Dreger, P; Luft, T; Monteagudo, E; Müller-Tidow, C; Orsatti, L; Radujkovic, A; Speziale, R; Stiehl, T, 2021) |
| "Kidney fibrosis is considered the final convergent pathway for progressive chronic kidney diseases, but there is still a paucity of success in clinical application for effective therapy." | ( Cai, G; Cai, H; Chen, XM; He, JC; Hong, Q; Lee, K; Li, Z; Ni, Z; Zhang, L; Zhong, F, 2022) |
| "Renal fibrosis is the final common result of a variety of progressive injuries leading to chronic renal failure." | ( Ding, K; Huang, C; Jing, X; Wu, Q, 2022) |
| "Although renal fibrosis is associated with renal aging, whether AA induces renal aging remains unclear." | ( Abe, E; Atobe, Y; Azushima, K; Funakoshi, K; Kanaoka, T; Kinguchi, S; Suzuki, T; Taguchi, S; Tamura, K; Tanaka, S; Tsukamoto, S; Uneda, K; Urate, S; Wakui, H; Yamaji, T; Yamashita, A, 2021) |
| "Pulmonary fibrosis is a chronic, fibrotic lung disease affecting 3 million people worldwide." | ( Azuelos, I; Baglole, CJ; Eidelman, DH; Haidar, Z; Huang, MJ; Morganstein, T; Trivlidis, J, 2021) |
| "Intestinal fibrosis is a serious complication of Crohn's disease." | ( Barrett, RJ; Casero, D; Estrada, HQ; Patel, S; Rabizadeh, S; Targan, SR, 2022) |
| "Intestinal fibrosis is a serious complication of Crohn’s disease and novel in vitro models are urgently needed to study this." | ( Barrett, RJ; Casero, D; Estrada, HQ; Patel, S; Rabizadeh, S; Targan, SR, 2022) |
| "Left atrial (LA) fibrosis is a hallmark of atrial cardiomyopathy, and non-invasive surrogate measures of LA fibrosis are therefore needed." | ( Bertelsen, L; Biering-Sørensen, T; Bjerregaard, CL; Brandes, A; Diederichsen, SZ; Graff, C; Haugan, K; Højberg, S; Krieger, D; Køber, L; Olsen, FJ; Svendsen, JH; Vejlstrup, N, 2022) |
| "Kidney fibrosis is a common characteristic of chronic kidney disease and while the large conductance voltage and calcium-activated potassium channel (BK) is widely expressed in kidneys, its role in kidney fibrosis is unknown." | ( Cai, H; Eaton, DC; Farris, AB; Jiang, G; Ning, F; Ren, D; Tao, J; Wang, M; Wang, Y; Xie, W; Xin, H; Zhang, X, 2022) |
| "Renal fibrosis is the common outcome in all progressive forms of chronic kidney disease." | ( He, J; Hu, P; Li, C; Ning, F; Reilly, S; Sun, X; Wang, C; Wang, M; Wang, Y; Xiao, J; Xin, H; Xu, X; Zeng, F; Zhang, D; Zhang, X; Zhou, S, 2022) |
| "Renal fibrosis is a major driver of chronic kidney disease, yet current treatment strategies are ineffective in attenuating fibrogenesis." | ( Jensen, MS; Kresse, JC; Madsen, MG; Mutsaers, HAM; Nejsum, LN; Nørregaard, R; Praetorius, H; Tingskov, SJ, 2022) |
| "Intestinal fibrosis is the most common complication of inflammatory bowel disease; nevertheless, specific therapies are still unavailable." | ( Bai, T; Liu, X; Xiong, D; Zeng, C; Zou, K, 2022) |
| "Renal fibrosis is the expected outcome of many chronic kidney diseases, and effective treatments are needed." | ( Fan, X; Hou, Y; Li, F; Piao, J; Sun, J; Wei, Y; Xu, Z; Yao, W; Zheng, H, 2022) |
| "Inflammation and fibrosis are two pathological features of chronic kidney disease (CKD)." | ( Abdelfattah, WH; Ali, HA; El-Eraky, AM; El-Sayed, MA; El-Tabakh, NM; Elmorsy, MA; Ghanim, AMH; Ibrahim, EE; Jabban, MZ; Kandil, KK; Mahmoud, ME; Metwaly, HA; Motawea, AM, 2022) |
| "Synovial fibrosis is a pathological process which contributes to joint pain and stiffness in several musculoskeletal disorders." | ( Blanco, FJ; Dominguez, H; Flórez-Fernández, N; Meijide-Faílde, R; Piñeiro-Ramil, M; Ramil-Gómez, O; Torres, MD; Vaamonde-García, C, 2022) |
| "Tissue fibrosis is a key factor leading to disability and death worldwide; however, thus far, there are no approved treatments for fibrosis." | ( Jiang, X; Liu, W; Luo, L; Ren, C; Shi, N; Wang, Z; Zhang, Y; Zhao, J; Zhao, M; Zhu, H, 2022) |
| "Myocardial fibrosis is a concomitant bioprocess associated with many cardiovascular diseases (CVDs)." | ( Chen, L; Hu, L; Huang, K; Liang, M; Shu, J; Wang, Z; Wu, Y, 2022) |
| "Knee arthrofibrosis is a common complication of knee surgery, caused by excessive scar tissue, which results in functional disability." | ( Kikuchi, K; Maruyama, I; Matsuoka, T; Matsuzaki, R; Nakakogawa, T; Nakanishi, K; Norimatsu, K; Otsuka, S; Sakakima, H; Setoyama, K; Takada, S; Tanaka, E; Tancharoen, S; Tani, A; Uchikado, H, 2022) |
| "Kidney fibrosis is the final common pathway of progressive kidney diseases, the underlying mechanisms of which are not fully understood." | ( Cheng, J; Jiang, B; Kong, Y; Li, C; Li, J; Liang, B; Lin, Y; Wang, W; Xu, J; Zhao, X; Zhou, N, 2022) |
| "Currently, kidney fibrosis is only detectable by an invasive procedure." | ( Bahinipati, J; Gupta, P; Mahapatra, S; Mohapatra, SR; Pathak, M; Sarangi, R; Tripathy, KP, 2022) |
| "Orbital fibrosis is a hallmark of tissue remodeling in thyroid-associated ophthalmopathy (TAO)." | ( Hei, X; Huang, D; Huang, S; Ke, Y; Lin, B; Meng, J; Wu, P; Yang, H; Zhang, F; Zhou, M, 2022) |
| "Pulmonary fibrosis is a progressive fibrotic disease with a poor prognosis and has suboptimal therapeutic options." | ( Matsushima, K; Ogawa, S; Ogawa, T; Shichino, S; Ueha, S, 2022) |
| "Myocardial fibrosis is the main pathological mechanism, and it is associated with transforming growth factor-β1(TGF-β1) expression up-regulation." | ( Chen, G; Chen, Z; Zheng, L, 2023) |
| "Liver fibrosis is a dynamic and highly integrated pathological process resulting from repeated liver injury healing accompanied by inflammation and extracellular matrix deposition." | ( Dai, R; Feng, W; Li, B; Li, J, 2022) |
| "Fibrosis is defined as an excessive accumulation of extracellular matrix (ECM) components." | ( Albert, V; Bensalah, M; Bigot, A; Boulinguiez, A; Butler-Browne, G; Corneau, A; Dhiab, J; Gidaro, T; Giordani, L; Hanique, V; Lacau St-Guily, J; Mouly, V; Muraine, L; Negroni, E; Oliver, A; Perié, S; Trollet, C; Ythier, V, 2022) |
| "Fibrosis is a central pathway that drives progression of multiple chronic diseases, yet few safe and effective clinical antifibrotic therapies exist." | ( Atin, C; Attisano, L; Caldwell, L; Chan, K; Chen, X; Christova, T; Gill, MK; Goru, SK; Gregorieff, A; He, X; Hu, C; Kirpalani, A; Krizova, A; Liu, Y; McEvoy, CM; Misra, PS; Ni, R; Tolosa, MF; Ulloa Severino, L; Vukosa, N; Wrana, JL; Yuen, DA; Zhang, J; Zhang, T, 2022) |
| "Cardiac fibrosis is one of the major causes of heart failure." | ( Bi, FF; Cao, M; Cui, C; Hou, YM; Jing, ZH; Li, JR; Li, XL; Lv, LF; Pan, QM; Shan, HL; Wu, CY; Wu, Y; Zhai, X; Zhou, YH, 2022) |
| "Cardiac fibrosis is a key feature of hypertensive cardiac remodeling." | ( Fan, X; Guo, Z; Ma, R; Qi, M; Sun, R; Wang, Q; Wang, W; Yu, J; Zhu, J; Zhuang, C, 2022) |
| "Cardiac fibrosis is a common pathological process in cardiovascular disease that results from the excessive accumulation of extracellular matrix (ECM), and the transforming growth factor (TGF)-β/Smad pathway is a canonical signaling pathway that directly induces expressions of ECM-related genes." | ( Chai, X; Chen, P; Gao, X; Ge, F; Huang, L; Huang, M; Jiao, S; Li, J; Liu, J; Tu, P; Wuken, S, 2022) |
| "Fibrosis is an accumulation of extracellular matrix (ECM) proteins and fibers in a disordered fashion, which compromises cell and tissue functions." | ( Miller, CG; Resnikoff, HA; Schwarzbauer, JE, 2022) |
| "Advanced hepatic fibrosis is strongly associated with arthritis in HFE hemochromatosis." | ( Andersson, L; Olynyk, JK; Powell, LW; Ramm, GA; Ramm, LE, 2022) |
| "Fibrosis is an excessive accumulation of the extracellular matrix within solid organs in response to injury and a common pathway that leads functional failure." | ( Chao, CH; Chen, LH; Chen, Y; Chen, YT; Cheng, HT; Huang, HC; Huang, KH; Huang, KW; Jin, PR; Juang, IP; Lee, TY; Liao, YH; Lin, SL; Lin, TC; Liu, ZY; Sheng, YH; Su, CT; Sung, YC; Wang, HC; Wang, J, 2022) |
| "Renal fibrosis is the ultimate presentation of chronic kidney disease, which progresses to end-stage renal disease." | ( Bai, F; Fan, J; Feng, F; Li, D; Liu, L; Sun, N; Yang, H; Yang, X; Yu, K; Zhang, Y, 2022) |
| "Renal fibrosis is the final common pathological feature of various chronic kidney diseases (CKD)." | ( Fan, X; Hou, Y; Piao, JG; Sun, J; Wei, Y; Xu, Z; Yao, W; Zhang, K; Zhang, Q; Zhu, L, 2022) |
| "Renal fibrosis is the final common outcome of chronic kidney disease (CKD), which remains a huge challenge due to a lack of targeted treatment." | ( Chen, J; Han, F; Jin, L; Liu, G; Nie, W; Wang, J; Xia, H; Xiao, L; Yang, Y; Yu, B, 2022) |
| "Renal fibrosis is a common pathological process of chronic kidney diseases induced by multiple factors." | ( Chen, L; Chen, Q; Chen, X; Gao, Z; Peng, F; Wang, X; Zhang, C; Zhao, Y, 2022) |
| "Hepatic fibrosis is an important early stage in the evolution of liver cirrhosis, and specific medicine and therapeutic measures are unavailable to date." | ( Ge, X; Liu, Q; Pang, H; Wang, C; Wang, L; Ye, J; Zhang, J; Zhou, X, 2022) |
| "Renal fibrosis is an irreversible and progressive process that causes severe dysfunction in chronic kidney disease (CKD)." | ( Chang, YK; Choi, DE; Choi, H; Jeong, JY; Jin, JA; Kang, TW; Kim, SH; Lee, HK; Lee, JU; Lee, SH; Lee, Y; Seo, YK; So, HJ, 2022) |
| "Liver fibrosis is a major cause of morbidity and mortality in patients with chronic liver inflammation such as that caused by non-alcoholic steatohepatitis." | ( Cho, K; Jung, HJ; Kim, SY; Oh, SH; Seong, JK, 2022) |
| "Renal fibrosis is a hallmark feature of chronic kidney diseases (CKDs)." | ( Aslam Saifi, M; Godugu, C; Hirawat, R, 2023) |
| "Cardiac fibrosis is a pathogenic factor of many cardiovascular diseases (CVD), which seriously affects people's life and health, causing huge economic losses." | ( Gao, W; Han, X; Huang, L; Ji, H; Li, X; Liu, C; Qiao, O; Wang, J; Wang, W; Zhang, X; Zhang, Y, 2022) |
| "Fibrosis is a chronic inflammation caused by the loss of innate compensational mechanisms." | ( Kohan, L; Mohammadi, M; Mohammadi, S; Saeidi, M; Saghaeian Jazi, M, 2022) |
| "Uterine fibrosis is one of the main factors of female reproductive disorders." | ( Chen, T; Liu, J; Wu, H; Xu, S; Xu, T, 2022) |
| "A hallmark of fibrosis is the aberrant activation and accumulation of myofibroblasts, which is caused by excessive profibrotic cytokines." | ( He, X; Huang, S; Jiang, C; Li, B; Liu, Z; Long, Q; Qian, B; Santos, HA; Shao, Q; Shi, H; Wei, X; Xiang, X; Yan, X; Yang, Y; Ye, X; Zhao, Q; Zhong, Y, 2022) |
| "Cardiac fibrosis is a process characterized by extracellular matrix accumulation leading to myocardial dysfunction." | ( Han, X; Hao, H; Li, C; Li, W; Li, Y; Liang, C; Liu, HE; Liu, S; Liu, Y; Luo, Y; Pan, Z; Su, M; Sun, LI; Wei, Y; Yan, S; Yuan, Y; Zhang, R; Zhao, X, 2022) |
| "Renal fibrosis is the inevitable common end-point of all progressive chronic kidney diseases." | ( Du, Y; Jiang, L; Jin, D; Li, C; Long, M; Miao, C; Wei, X; Zhu, X, 2022) |
| "Renal fibrosis is the final stage of chronic kidney injury characterized by glomerulosclerosis and tubulointerstitial fibrosis with parenchymal destruction." | ( Bastidas-Ramírez, BE; Gasca-Lozano, LE; Gurrola-Díaz, CM; Hernández-Ortega, LD; Martínez-Limón, FJ; Mena-Enríquez, M; Salazar-Montes, AM; Sánchez-Jaramillo, EA; Vargas-Guerrero, B; Vera-Cruz, JM, 2022) |
| "Renal fibrosis is a chronic pathological process that seriously endangers human health." | ( Bae, EH; Byon, CH; Choi, HI; Kim, DH; Kim, SW; Ma, SK; Park, JS; Sun, W, 2022) |
| "Liver fibrosis is a prevalent liver disease that requires rapid and effective treatment prior to its progression to cirrhosis and liver damage." | ( Albogami, SM; Alotaibi, SS; Batiha, GE; Elewa, YHA; Makled, S; Mostafa-Hedeab, G; Yassin, F; Zein, N, 2022) |
| "Hence, organ fibrosis is being actively researched worldwide." | ( Huang, X; Lan, Y; Lei, Y; Li, J; Liu, R; Luo, X; Yang, F; Zeng, F, 2022) |
| "Liver fibrosis is an important process in chronic liver disease and is strongly related to poor prognosis." | ( Bao, YY; Chen, MH; Ge, MX; He, HW; Li, Y; Li, YM; Lu, ZN; Niu, WX; Zhang, N, 2022) |
| "Renal fibrosis is a final common pathway to end-stage renal disease independent of the underlying etiology, and connective tissue growth factor (CTGF) is a well-recognized profibrotic factor in fibrosis of various organ systems." | ( Azegami, T; Hayashi, K; Hishikawa, A; Itoh, H; Nakamichi, R; Nakayama, T; Sugita, E; Yoshimoto, N, 2022) |
| "Atrial fibrosis is an essential contributor to atrial fibrillation (AF)." | ( Chang, GJ; Chang, SH; Chen, WJ; Huang, CC; Lai, YJ; Tsai, FC; Yeh, YH, 2022) |
| "Fibrosis is the last revertible stage in the progress of middle ear inflammation to TS." | ( Chen, M; Chi, Z; Li, Q; Liu, YW; Mao, J; Min, S; Zhang, C, 2022) |
| "Intestinal fibrosis is a common complication of inflammatory bowel diseases." | ( Boirivant, M; Butera, A; Campanile, D; Crippa, L; Di Carlo, N; Labbaye, C; Quaranta, MT; Saulle, E; Spinello, I, 2022) |
| "Myocardial fibrosis is the main pathological manifestation of hypertensive heart failure, and Shenmai Injection could inhibit myocardial fibrosis and effectively improve heart failure by regulating TGF-β 1/Smad signaling pathway." | ( Hu, SY; Hu, ZX; Huang, SM; Li, L; Li, XC; Yang, M; Zhong, SJ; Zhou, Y, 2023) |
| "Lung fibrosis is the leading cause of death in SSc, with no cure currently available." | ( Feghali-Bostwick, C; Mouawad, JE; Nadig, SN; Pilewski, JM; Renaud, L; Sharma, S, 2023) |
| "Liver fibrosis is a common cause of chronic liver disease." | ( Chen, K; Gao, Q; Guo, W; Han, Y; Li, R; Wang, S, 2022) |
| "Pulmonary fibrosis is a fatal lung disease characterized by progressive fibroblast proliferation and extensive extracellular matrix (ECM) deposition." | ( Chen, S; Fang, Y; Li, P; Wan, X; Xie, S; Zhao, T, 2022) |
| "Hepatic fibrosis is a major global health problem and considered a leading cause of liver-related morbidity and mortality worldwide." | ( Cao, Z; Chu, Y; Du, H; Fang, Y; Fu, J; Kuang, T; Lei, X; Liang, XM; Liu, G; Liu, Q; Liu, Z; Mori, M; Qian, K; Wu, X; Xie, C; Xu, G; Xu, X; Yamamoto, H; Yan, L; Zhang, J, 2022) |
| "Fibrosis is considered the base and the fate of CKD; thus, the goal of this study was to evaluate the effects of sodium molybdate on cisplatin-induced CKD model and demonstrate the possible involved mechanisms." | ( El-Waseif, EG; Sharawy, MH; Suddek, GM, 2022) |
| "Renal fibrosis is the result of renal tissue damage and repair response disorders." | ( Du, Y; Hou, Y; Jiang, L; Long, M; Wei, X, 2022) |
| "Cardiac fibrosis is a common precursor of ventricular dysfunction and heart failure." | ( Gao, Y; Gong, Y; He, Q; Huang, C; Li, X; Liu, W; Wei, S; Wu, H; Xu, Z; Yao, H; Zheng, C, 2022) |
| "Cardiac fibrosis is characterized by the net accumulation of extracellular matrix in the myocardium and is an integral component of most pathological cardiac conditions." | ( Hada, Y; Uchida, HA; Umebayashi, R; Wada, J; Yoshida, M, 2022) |
| "Intestinal fibrosis is a common complication in inflammatory bowel disease (IBD) patients without specific treatment." | ( Amamou, A; Bôle-Feysot, C; Leboutte, M; Marion-Letellier, R; Savoye, G; Yaker, L, 2022) |
| "Cardiac fibrosis is a common irreversible pathological feature of diverse heart disorders." | ( Jiang, Y; Liu, X; Tan, Y; Wang, B; Yang, J; Zhan, Z; Zhou, W, 2022) |
| "Cardiac fibrosis is a major structural change observed in the heart of patients with type 2 diabetes mellitus (T2DM), ultimately resulting in heart failure (HF)." | ( Hu, XP; Huang, P; Huang, ZJ; Liu, T; Pan, ZF; Shi, JN; Sun, ZY; Xu, YN; Yuan, MN; Zhang, YW; Zou, XZ, 2022) |
| "Ovarian fibrosis is a pathological condition associated with aging and is responsible for a variety of ovarian dysfunctions." | ( Cook, DP; Fasih, S; Landry, DA; Upham, J; Vanderhyden, BC; Yakubovich, E, 2022) |
| "Organ fibrosis is accompanied by pathological angiogenesis." | ( Ben, H; Qing, J; Ren, Y; Wang, L; Yang, S; Yang, X; Zhang, Y; Zhao, F, 2022) |
| "Renal interstitial fibrosis is a common pathological feature of a variety of kidney diseases that progress to end-stage renal disease." | ( An, N; Cai, S; Pei, J; Peng, J; Wang, D; Wang, W; Wu, M; Zhan, X, 2022) |
| "Renal fibrosis is the result of a complex combination of a variety of lesions." | ( Ma, Y; Yu, R; Zhou, X; Zou, J, 2022) |
| "Liver fibrosis is a serious cause of morbidity and mortality worldwide characterized by accumulation of extracellular matrix produced by hepatic stellate cells (HSCs)." | ( Chen, R; Chen, X; Chen, Y; Cong, W; Dong, Y; Fan, J; Gong, W; Hu, Z; Jin, L; Li, S; Tong, G; Yu, Y; Zhou, B; Zhu, J; Zhu, K; Zhu, S, 2023) |
| "Renal fibrosis is an important pathological condition in patients with CKD." | ( Chen, Y; Chen, ZW; Dong, ZH; He, Y; Hou, R; Jin, J; Li, C; Li, J; Liu, MM; Ma, WX; Meng, XM; Ni, WJ; Suo, XG; Wang, JN; Wen, JG; Xie, SS; Xu, CH; Yang, Q; Yu, JT, 2022) |
| "Adipose tissue fibrosis is a typical feature of adipose tissue dysfunction in obese individuals, which is closely related to metabolic diseases." | ( Chen, H; Ding, F; Hu, X; Li, Z; Sun, A; Yan, X; Yan, YE; Zheng, P, 2022) |
| "Liver fibrosis is a pathological process of multiple chronic liver diseases progressing to cirrhosis for which there are currently no effective treatment options." | ( Bi, J; Cao, Y; Li, J; Li, Y; Liang, Q; Liu, J; Liu, Y; Yang, J; Zhou, L, 2022) |
| "Fibrosis is a common final pathway of chronic kidney disease, which is a major incurable disease." | ( Jung, K; Kim, J; Lee, T; Song, I; Sung, E, 2022) |
| "Renal fibrosis is the inevitable pathway of the progression of chronic kidney disease to end-stage renal disease, which manifests as progressive glomerulosclerosis and renal interstitial fibrosis." | ( Chang, Y; Gao, X; Han, Y; Hao, J; Liang, L; Qiang, P; Shimosawa, T; Xian, Y; Xiong, Y; Xu, Q; Yang, F, 2022) |
| "Renal fibrosis is most common among chronic kidney diseases." | ( Hu, L; Ma, C; Wei, J; Zhang, H; Zhang, Y, 2022) |
| "Cardiac fibrosis is common in patients with CKD with left ventricular diastolic dysfunction, and it is associated with increased risk of heart failure and mortality." | ( Hirayama, A; Ishimoto, T; Ito, Y; Kamiya, K; Kim, H; Kinashi, H; Kunoki, S; Mizuno, M; Nobata, H; Sakai, Y; Sakata, F; Soga, T; Sun, T; Tanaka, H; Yamaguchi, M; Yoshikawa, K, 2022) |
| "Liver fibrosis is a common scarring response and may ultimately lead to liver cancer, unfortunately, there is currently no effective antifibrotic drug approved for human use." | ( Dong, R; Kong, L; Leng, Y; Liu, J; Luo, J; Wu, E; Xu, W; Yang, T; Ye, S; Zhang, H; Zheng, Y; Zhong, J; Zhu, X, 2022) |
| "Fibrosis is a common pathophysiological response of many tissues and organs subjected to chronic injury." | ( Kanashiro-Galo, L; Mosser, DM; Pagliari, C; Quaresma, JAS; Silva, AMG; Sotto, MN; Tafuri, WL; Tomokane, TY, 2022) |
| "Cardiac fibrosis is a severe condition with limited therapeutic options and often occurs in chronic cardiovascular diseases such as hypertension and myocardial infarction." | ( Chen, W; Han, L; Ji, H; Yu, L; Zhu, H, 2022) |
| "Hepatic fibrosis is a common pathologic stage in chronic liver disease development, which might ultimately lead to liver cirrhosis." | ( Feng, J; Fu, Q; Guo, J; Ling, B; Ning, K; Wang, J; Wu, B; Xiu, G; Xu, J, 2022) |
| "Renal fibrosis is a global health concern with limited curative treatment." | ( Cao, Z; Chai, C; Ge, H; Gu, L; Hu, Y; Jiang, S; Ren, Y; Yang, Z; Yu, B; Zhao, F, 2022) |
| "Cardiac fibrosis is a hallmark of various cardiovascular diseases, which is quite commonly found in obesity, and may contribute to the increased incidence of heart failure arrhythmias, and sudden cardiac death in obese populations." | ( Li, P; Mao, Y; Sheng, Y; Zhao, K, 2023) |
| "Renal fibrosis is an inevitable outcome of various manifestations of progressive chronic kidney diseases (CKD)." | ( Alolga, RN; Bian, XY; Chen, C; Jiang, H; Li, J; Liu, HL; Liu, SJ; Liu, YF; Shan, JJ; Si, ZL; Tan, NH; Wang, H; Wu, WH; Zhang, ZH; Zhou, W, 2022) |
| "Kidney fibrosis is a common pathway that leads to chronic kidney disease." | ( Abe, E; Azushima, K; Hirota, K; Suzuki, T; Taguchi, S; Takahashi, H; Tamura, K; Tanaka, S; Tsukamoto, S; Uehara, T; Urate, S; Wakui, H; Yamaji, T; Yamashita, A, 2022) |
| "Cardiac fibrosis is a hallmark of numerous chronic cardiovascular diseases that leads to heart failure." | ( Duan, Y; Gu, H; Jiang, M; Li, S; Wang, C; Wang, Q; Yin, S; Zhen, W, 2022) |
| "Diabetes cardiac fibrosis is associated with altered DNA methylation of fibrogenic genes; however, the underlying mechanisms remain unclear." | ( Ding, JF; Sha, JM; Song, K; Sun, H; Tao, H; Tu, B; Yang, JJ; Zhang, Y; Zhao, JY; Zhou, Y, 2022) |
| "While fibrosis is primarily characterized by an accumulation of extracellular matrix (ECM) components, there are changes in ECM architecture during fibrosis that relate more closely to functional muscle stiffness." | ( Brashear, SE; Christiansen, BA; Hu, LY; Jbeily, EH; Smith, LR; Wohlgemuth, RP, 2022) |
| "Peritoneal fibrosis is a common complication of peritoneal dialysis (PD) with a complicated pathogenesis and limited treatments." | ( Chen, C; Feng, W; Huang, Y; Li, S; Liang, J; Lin, M; Long, H; Peng, X; Shen, H; Wang, Z; Xiao, L; Zhang, Y; Zhao, Y; Zhu, L, 2022) |
| "Fibrosis is a common complication of inflammatory bowel diseases (IBDs)." | ( Alston, LA; Flannigan, KL; Hirota, SA; Lee, JW; Mani, S; Nieves, KM; Ramay, H; Serra, A; Szczepanski, HE, 2023) |
| "Cardiac fibrosis is an integral aspect of every form of cardiovascular diseases, which is one of the leading causes of death worldwide." | ( Chen, J; Jin, X; Li, L; Ouyang, H; Pang, D; Tang, X; Wang, J; Zhang, H, 2022) |
| "Cardiac fibrosis is a common cause of most cardiovascular diseases." | ( Chen, K; Li, Z; Zhu, YZ, 2022) |
| "Kidney fibrosis is a common step during chronic kidney disease (CKD), and its incidence has been increasing worldwide." | ( Kandel, R; Singh, KP, 2022) |
| "Renal fibrosis is a common pathological feature of various kidney diseases, leading to irreversible renal failure and end-stage renal disease." | ( Chen, M; Guo, Q; Jin, L; Liu, X; Long, C; Mi, T; Pan, J; Shen, L; Tian, X; Wei, G; Xiang, B; Xu, T; Yu, Y; Zhang, D; Zhang, Y, 2022) |
| "Fibrosis is a pathological process in which parenchymal cells are necrotic and excess extracellular matrix (ECM) is accumulated due to dysregulation of tissue injury repair." | ( Jia, W; Wang, W; Zhang, C, 2022) |
| "Pulmonary fibrosis is a severe disease characterized by inflammation and fibrosis of unknown etiology and lacking an effective treatment." | ( Catarinicchia, S; Jacobson, KA; Lucarini, L; Marri, S; Masini, E; Pini, A; Salvemini, D; Sgambellone, S; Tosh, DK, 2022) |
| "Renal fibrosis is characterized by glomerulosclerosis and tubulointerstitial fibrosis and transforming growth factor-β." | ( Mukoyama, M; Toda, N; Yokoi, H, 2023) |
| "Cardiac fibrosis is a leading cause of cardiac dysfunction in patients with diabetes." | ( Chun, HJ; Guo, D; Hu, C; Hu, J; Hu, L; Li, Y; Liu, M; Peng, T; Qi, B; Ren, G; Song, L; Wang, D; Zhang, F, 2022) |
| "Cardiac fibrosis is a leading cause of cardiac dysfunction in patients with diabetes." | ( Chun, HJ; Guo, D; Hu, C; Hu, J; Hu, L; Li, Y; Liu, M; Peng, T; Qi, B; Ren, G; Song, L; Wang, D; Zhang, F, 2022) |
| "Cardiac fibrosis is a leading cause of cardiac dysfunction in patients with diabetes." | ( Chun, HJ; Guo, D; Hu, C; Hu, J; Hu, L; Li, Y; Liu, M; Peng, T; Qi, B; Ren, G; Song, L; Wang, D; Zhang, F, 2022) |
| "Myocardial fibrosis is a common pathophysiological process involved in many cardiovascular diseases." | ( Chen, C; Chen, X; Chen, Y; Gong, C; Guo, J; He, J; Pu, S; Wan, K; Wang, L; Wen, B; Yin, L, 2022) |
| "Myocardial fibrosis is a common feature of ES." | ( Chen, C; Chen, X; Chen, Y; Gong, C; Guo, J; He, J; Pu, S; Wan, K; Wang, L; Wen, B; Yin, L, 2022) |
| "Myocardial fibrosis is a common pathophysiological process involved in many cardiovascular diseases." | ( Chen, C; Chen, X; Chen, Y; Gong, C; Guo, J; He, J; Pu, S; Wan, K; Wang, L; Wen, B; Yin, L, 2022) |
| "Myocardial fibrosis is a common feature of ES." | ( Chen, C; Chen, X; Chen, Y; Gong, C; Guo, J; He, J; Pu, S; Wan, K; Wang, L; Wen, B; Yin, L, 2022) |
| "Myocardial fibrosis is a common pathophysiological process involved in many cardiovascular diseases." | ( Chen, C; Chen, X; Chen, Y; Gong, C; Guo, J; He, J; Pu, S; Wan, K; Wang, L; Wen, B; Yin, L, 2022) |
| "Myocardial fibrosis is a common feature of ES." | ( Chen, C; Chen, X; Chen, Y; Gong, C; Guo, J; He, J; Pu, S; Wan, K; Wang, L; Wen, B; Yin, L, 2022) |
| "Renal fibrosis is the final manifestation of chronic kidney disease (CKD) regardless of etiology." | ( Kim, DA; Kim, M; Kong, KH; Lee, MR; Oh, HJ, 2023) |
| "Renal fibrosis is the final manifestation of chronic kidney disease (CKD) regardless of etiology." | ( Kim, DA; Kim, M; Kong, KH; Lee, MR; Oh, HJ, 2023) |
| "Renal fibrosis is the final manifestation of chronic kidney disease (CKD) regardless of etiology." | ( Kim, DA; Kim, M; Kong, KH; Lee, MR; Oh, HJ, 2023) |
| "Atrial fibrosis is an important pathophysiological event in the progression of atrial fibrillation (AF)." | ( Kong, Y; Li, L; Li, W; Lou, Q; Yang, W; Zhang, L; Zhang, W; Zhao, H, 2023) |
| "Atrial fibrosis is an important pathophysiological event in the progression of atrial fibrillation (AF)." | ( Kong, Y; Li, L; Li, W; Lou, Q; Yang, W; Zhang, L; Zhang, W; Zhao, H, 2023) |
| "Atrial fibrosis is an important pathophysiological event in the progression of atrial fibrillation (AF)." | ( Kong, Y; Li, L; Li, W; Lou, Q; Yang, W; Zhang, L; Zhang, W; Zhao, H, 2023) |
| "Fibrosis is often diagnosed in various organs, including the liver, lungs, kidneys, heart, and skin, and has been described as excessive accumulation of extracellular matrix that can affect specific organs in the body or systemically throughout the body." | ( Beaven, E; Bhatt, HN; Esquivel, SV; Kumar, R; Nurunnabi, M, 2022) |
| "Fibrosis is often diagnosed in various organs, including the liver, lungs, kidneys, heart, and skin, and has been described as excessive accumulation of extracellular matrix that can affect specific organs in the body or systemically throughout the body." | ( Beaven, E; Bhatt, HN; Esquivel, SV; Kumar, R; Nurunnabi, M, 2022) |
| "Myocardial fibrosis is a common pathological companion of various cardiovascular diseases." | ( Akram, HMB; Aziz, S; Lemin, J; Raza, MA; Yalan, L; Zhao, W, 2023) |
| "Myocardial fibrosis is a common pathological companion of various cardiovascular diseases." | ( Akram, HMB; Aziz, S; Lemin, J; Raza, MA; Yalan, L; Zhao, W, 2023) |
| "Renal interstitial fibrosis is the common pathological process of various chronic kidney diseases to end-stage renal disease." | ( Chen, DQ; Chen, L; Guo, Y; Li, P; Wu, XQ; Yan, MH; Zhang, GQ; Zhang, HJ; Zhao, HL; Zhao, TT, 2023) |
| "Renal interstitial fibrosis is the common pathological process of various chronic kidney diseases to end-stage renal disease." | ( Chen, DQ; Chen, L; Guo, Y; Li, P; Wu, XQ; Yan, MH; Zhang, GQ; Zhang, HJ; Zhao, HL; Zhao, TT, 2023) |
| "Colonic fibrosis is associated with altered bowel motility and induction of profibrotic factors driven by TGF-β signalling." | ( Antonioli, L; Bernardini, N; Blandizzi, C; Colucci, R; Fornai, M; Ippolito, C; Nericcio, A; Pellegrini, C; Segnani, C; Serio, R; Zizzo, MG, 2023) |
| "Colonic fibrosis is associated with altered bowel motility and induction of profibrotic factors driven by TGF-β signalling." | ( Antonioli, L; Bernardini, N; Blandizzi, C; Colucci, R; Fornai, M; Ippolito, C; Nericcio, A; Pellegrini, C; Segnani, C; Serio, R; Zizzo, MG, 2023) |
| "Skin fibrosis is a hallmark of a wide array of dermatological diseases which can greatly impact the patients' quality of life." | ( Almudéver, P; Alonso-Carpio, M; Cortijo, J; Marín, S; Milara, J; Montero, P; Peiró, T; Ribera, P; Roger, I, 2022) |
| "Skin fibrosis is a hallmark of a wide array of dermatological diseases which can greatly impact the patients' quality of life." | ( Almudéver, P; Alonso-Carpio, M; Cortijo, J; Marín, S; Milara, J; Montero, P; Peiró, T; Ribera, P; Roger, I, 2022) |
| "Fibrosis is a hallmark of chronic hypertension and disrupts the viability of human bone marrow-derived mesenchymal stromal cells (BM-MSCs) post-transplantation." | ( Broughton, BRS; de Veer, M; Li, Y; Ricardo, SD; Salimova, E; Samuel, CS; Zheng, G, 2023) |
| "Fibrosis is a hallmark of chronic hypertension and disrupts the viability of human bone marrow-derived mesenchymal stromal cells (BM-MSCs) post-transplantation." | ( Broughton, BRS; de Veer, M; Li, Y; Ricardo, SD; Salimova, E; Samuel, CS; Zheng, G, 2023) |
| "Fibrosis is a common pathological feature of organ diseases resulting from excessive production of extracellular matrix, which accounts for significant morbidity and mortality." | ( Hu, X; Ning, F; Reilly, S; Wang, M; Wu, T; Xin, H; Zhang, X; Zhou, S, 2023) |
| "Fibrosis is a common pathological feature of organ diseases resulting from excessive production of extracellular matrix, which accounts for significant morbidity and mortality." | ( Hu, X; Ning, F; Reilly, S; Wang, M; Wu, T; Xin, H; Zhang, X; Zhou, S, 2023) |
| "Pancreatic fibrosis is mainly manifested by imbalance in extracellular matrix (ECM) homeostasis due to excessive deposition of collagen in pancreas by activated pancreatic stellate cells (PSCs)." | ( Han, H; Han, MM; Jiang, HL; Li, L; Pandol, SJ; Qi, L; Sun, Y; Xing, L, 2023) |
| "Pancreatic fibrosis is mainly manifested by imbalance in extracellular matrix (ECM) homeostasis due to excessive deposition of collagen in pancreas by activated pancreatic stellate cells (PSCs)." | ( Han, H; Han, MM; Jiang, HL; Li, L; Pandol, SJ; Qi, L; Sun, Y; Xing, L, 2023) |
| "Renal fibrosis is a common pathway and pathological marker of virtually every type of chronic kidney disease (CKD), and amelioration of renal fibrosis is of utmost importance to reduce the progression of CKD." | ( Afsar, B; Afsar, RE, 2023) |
| "Skeletal muscle fibrosis is one of the significant pathological manifestations associated with the development of age-related sarcopenia." | ( Fu, R; Li, Y; Sun, Y; Wu, Y; Xiao, Q; Yu, J; Zhang, Y; Zhao, K, 2023) |
| "Bone marrow (BM) fibrosis is a condition characterized by deposition of reticulin and collagen fibers in BM." | ( Asano, N; Igarashi, K; Ishida, F; Kaiume, H; Nakazawa, H; Uehara, T; Umemura, T; Yamazaki, T, 2023) |
| "Airway fibrosis is one of the pathological characteristics of severe asthma." | ( Chen, BC; Chen, CL; Cheng, WH; Kao, SY; Lin, CH; Lin, LY; Yuliani, FS, 2022) |
| "Fibrosis is an important pathological mechanism in heart failure (HF) and is associated with poor prognosis." | ( Isono, T; Kageyama, S; Kawauchi, A; Kubota, S; Matsumoto, T; Suzaki, M; Wada, A, 2022) |
| "Cardiac fibrosis is an essential structural remodeling associated with HF; therefore, preventing cardiac fibrosis is crucial to decelerating the progression of HF." | ( Adu-Amankwaah, J; An, K; Cui, J; Lin, L; Song, N; Sun, H; Tan, R; Wang, M; You, Q; Yuan, J, 2023) |
| "Fibrosis is the end-stage pathological manifestation of many chronic diseases." | ( Li, K; Wang, W; Xiao, W, 2023) |
| "Liver fibrosis is a disease with significant morbidity and mortality." | ( Hu, C; Huang, Y; Li, B; Li, Y; Qian, F; Sun, W; Yang, F; Zhang, A, 2023) |
| "Renal fibrosis is scarring and tissue hardening caused by the excess deposition of extracellular matrix proteins in response to chronic inflammation." | ( Hattori, K; Ishida, T; Nagao, G; Sawa-Aihara, A; Yamada, Y, 2023) |
| "Liver fibrosis is the underlying causeof hepatitis C virus (HCV)-related disease progression to endpoints such as cirrhosis, liver failure, and hepatocellular carcinoma." | ( Abdel-Rahman, YO; Abdel-Razik, W; Dabbous, HM; Elakel, W; Elmakhzangy, H; Elshafaey, A; Esmat, G; Ismail, SA; Omar, H; Saeed, R; Salama, R; Waked, I; Ziada, DH, 2023) |
| "Liver fibrosis is a worldwide public health problem due to its life-threatening complications, including portal hypertension, liver failure, cirrhosis, and hepatocellular carcinoma (HCC)." | ( Erdem Koc, G; Gokcimen, A; Sahin, F, 2023) |
| "Fibrosis is an inevitable stage in the development of chronic liver disease and has an irreplaceable role in characterizing the degree of progression of chronic liver disease." | ( Gou, J; Guan, T; He, Q; He, Y; Liu, Y; Shi, S; Yan, R; Ye, P; Zhou, G; Zhu, L, 2023) |
| "Tubulointerstitial fibrosis is observed in diabetic nephropathy." | ( Bianchi, C; Bombelli, S; Cifola, I; De Marco, S; Invernizzi, L; Meregalli, C; Morabito, I; Perego, RA; Strada, G; Torsello, B; Zucchini, N, 2023) |
| "Radiation-induced fibrosis is a common side effect of radiotherapy, which is the most common treatment for cancer." | ( Dawson, MR; Ghosh, D; Koh, IL; Lee, AH, 2023) |
| "Fibrosis is a pathological state caused by excess deposition of extracellular matrix proteins in a tissue." | ( Basu, R; Bell, S; Berryman, DE; Caggiano, LJ; Geitgey, DK; Kopchick, JJ; Lach, G; Lee, K; List, EO; Okada, S; Swegan, D; Young, JA, 2023) |
| "Tubulointerstitial fibrosis is a common pathological change in end-stage renal disease." | ( Guo, H; Han, R; Li, J; Liu, X; Ni, Y; Wang, L; Zhu, B, 2023) |
| "Renal fibrosis is an important pathological cause for MM patients combined with renal insufficiency." | ( Cheng, Q; Liu, J; Liu, L; Liu, R, 2023) |
| "Hepatic fibrosis is a late stage process of many chronic liver diseases." | ( Fan, S; Huang, C; Liu, C; Yin, L; Zhang, L, 2023) |
| "Renal interstitial fibrosis is a hallmark of CKD progression." | ( Guan, J; Ni, W; Wang, M; Zhang, M; Zhao, M, 2023) |
| "Renal fibrosis is one of the main pathophysiological processes underlying the progression of chronic kidney disease and kidney allograft failure." | ( Jensen, MS; Kresse, JC; Madsen, MG; Mutsaers, HAM; Nørregaard, R; Tingskov, SJ, 2023) |
| "Renal fibrosis is a hallmark of chronic and progressive renal diseases characterized by excessive fibroblast proliferation, extracellular matrix accumulation, and a loss of renal function, eventually leading to end-stage renal diseases." | ( Cheng, YT; Chien, YS; Chung, YH; Huang, GK; Kang, CH; Kao, YH, 2023) |
| "Pulmonary fibrosis is a severe condition in interstitial lung diseases (ILD) such as idiopathic pulmonary fibrosis (IPF) and systemic sclerosis-ILD, where the underlying mechanism is not well defined and with no curative treatments available." | ( Brunnström, H; Dellgren, G; Löfdahl, A; Nybom, A; Wenglén, C; Westergren-Thorsson, G; Wigén, J, 2023) |
| "Ocular tissue fibrosis is involved in the development of myopia and this study aimed to investigate the effect of miR-138-5p on choroidal fibrosis in myopic guinea pigs via regulating the HIF-1α signaling pathway." | ( Bao, B; Bi, H; Guo, D; Hao, J; Hao, Y; Jiang, W; Li, T; Li, X; Liu, J; Wei, H; Yang, Z; Zhang, R; Zhou, M, 2023) |
| "Cystic fibrosis is a life-threatening genetic disorder caused by mutations in the CFTR chloride channel." | ( Hu, Y; Jennings, S; Luo, M; Nauseef, WM; Scull, C; Taylor, CM; Wang, G; Wellems, D, 2023) |
| "Renal fibrosis is the common histopathological feature of chronic kidney diseases (CKD), and there is increasing evidence that epigenetic regulation is involved in the occurrence and progression of renal fibrosis." | ( Fan, X; Huang, T; Lang, Y; Li, X; Lv, Z; Sheng, Q; Wang, Q; Wang, R; Zhang, T; Zhao, Y; Zhen, J; Zhou, P, 2023) |
| "Interstitial fibrosis is the key pathological characteristics of chronic kidney diseases (CKD)." | ( Deng, C; Han, RY; Jia, J; Su, HW; Tan, RZ; Wang, L; Xie, KH; Xu, LH; Zhong, X, 2023) |
| "Cardiac fibrosis is a pathological process characterized by an excessive deposition of extracellular matrix (ECM) and an increased production of fibrillar collagen in the cardiac interstitium, mainly caused by the activation of cardiac fibroblasts and their transition into myofibroblasts." | ( Bitto, A; Booz, C; D'Angelo, T; Imbesi, C; Irrera, N; Mannino, F; Minutoli, L; Pallio, G; Squadrito, F, 2023) |
| "Renal fibrosis is the final common pathway of chronic kidney disease (CKD), which is clinically irreversible and without effective therapy." | ( Guan, H; Jiang, X; Lan, HY; Li, J; Li, N; Liu, Y; Shu, X; Xia, Y; Zheng, Z; Zhong, M; Zhu, E, 2023) |
| "Renal fibrosis is the major pathologic manifestation of chronic kidney disease (CKD)." | ( Bai, Y; Bian, X; He, P; Sun, G; Wu, Y; Yu, R; Zhang, B; Zhang, Y, 2023) |
| "Myocardial fibrosis is a pathological hallmark of cardiac dysfunction." | ( Buigues, M; Dekker, N; García, NA; González-King, H; Sepúlveda, P; Silva, AM; Tejedor, S, 2023) |
| "Renal fibrosis is a crucial pathological feature of hypertensive renal disease (HRD)." | ( Chen, X; Chen, Y; Fan, S; Li, Z; Liang, G; Lin, Y; Su, X; Wang, X; Zhao, Y, 2023) |
| "Kidney fibrosis is closely associated with the progression of chronic kidney disease (CKD)." | ( Atobe, T; Hara, H; Kadowaki, M; Kamiya, T; Kunieda, K; Morimoto, K, 2023) |
| "Cardiac fibrosis is a common pathological feature of cardiac remodelling process with disordered expression of multiple genes and eventually lead to heart failure." | ( Han, Z; Liu, C; Lu, M; Nie, Y; Wang, J; Zhang, H; Zhang, X, 2023) |
| "Cardiac fibrosis is a hallmark of heart disease and is associated with a stiff myocardium and heart failure." | ( Du, CX; Huang, CW; Ku, HC; Kuo, YH; Lee, SY, 2023) |
| "Kidney fibrosis is the common final pathway of nearly all chronic and progressive nephropathies." | ( Janssen, MJ; Masereeuw, R; Mihajlovic, M; Yang, Y, 2023) |
| "Cardiac fibrosis is the main pathological basis of diabetic cardiomyopathy (DCM), and endothelial-to-meschenymal transition (EndMT) is a key driver to cardiac fibrosis and plays an important role in the pathogenesis of DCM." | ( He, S; Huang, C; Jiang, J; Li, G; Li, N; Li, T; Niu, B; Tong, W; Wang, S; Wu, M; Wu, T; Yan, L, 2023) |
| "Liver fibrosis is a reversible wound-healing response that can lead to end-stage liver diseases without effective treatment, in which HBV infection is a major cause." | ( Cai, C; Chu, T; Fang, F; Feng, S; Feng, Y; Gao, B; He, M; Liu, Y; Lu, L; Shi, R; Wang, Z; Zhang, X, 2023) |
| "Liver fibrosis is a key global health care burden." | ( Bao, YY; Ge, MX; He, HW; Lu, ZN; Niu, WX, 2023) |
| "Fibrosis is a fundamental change occurring in impaired renal function and plays an important role in the progression of diabetic kidney disease (DKD)." | ( Da, J; Dai, L; Deng, Y; Dong, R; Huang, C; Yang, Y; Yu, J; Yuan, J, 2023) |
| "Furthermore, LV-LGE fibrosis is an independent predictor of cardiovascular disease mortality, which could be integrated into risk assessment in clinical management." | ( Alexanderson-Rosas, E; Antonio-Villa, NE; Aranda-Fraustro, A; Cabello-Ganem, A; Cano-Zarate, R; Espejel-Guzman, A; Espinola-Zavaleta, N; Fernandez-Badillo, V; Keirns, C; Meave-Gonzalez, A; Serrano-Roman, J; Solorzano-Pinot, E; Torres-Araujo, LV, 2023) |
| "Interstitial fibrosis is involved in the progression of various chronic kidney diseases and renal failure." | ( Li, XL; Shi, R; Wang, DG; Wang, ZJ; Zhao, WM; Zhu, Y, 2023) |
| "Cardiac fibrosis is one of the main contributors to the pathogenesis of heart failure." | ( Chen, F; Li, N; Lin, L; Shen, Y; Tang, W; Yao, Y, 2023) |
| "Skin fibrosis is a common pathological manifestation in systemic sclerosis (SSc), keloid, and localized scleroderma (LS) characterized by fibroblast activation and excessive extracellular matrix (ECM) deposition." | ( Gong, Y; Huang, Y; Jiang, S; Lin, J; Liu, J; Liu, Q; Ma, Y; Pu, W; Shi, X; Tang, Y; Wang, J; Wu, W; Zhang, Y; Zhao, H, 2023) |
| "Fibrosis is characterized by excessive accumulation of extracellular matrix, which is a key feature of uterine fibroids." | ( Brennan, JT; Islam, MS; Parish, M; Segars, JH; Winer, BL, 2023) |
| "Kidney fibrosis is the final manifestation of chronic kidney disease, a condition mainly caused by diabetic nephropathy." | ( Du, CX; Huang, CW; Ku, HC; Lee, SY, 2023) |
| "Fibrosis is the culprit in the electrical derangement of the myocytes." | ( Baroni, M; Carbonaro, M; Ciampi, CM; Fortuna, M; Giannattasio, C; Gigli, L; Leidi, F; Maloberti, A; Mazzone, P; Paolucci, M; Testoni, A; Vargiu, S; Varrenti, M, 2023) |
| "Vascular fibrosis is more prominent in TAK than in giant cell arteritis (GCA)." | ( Agarwal, V; Misra, DP; Sharma, A; Singh, K, 2023) |
| "Pulmonary fibrosis is a progressive and fatal fibrotic lung disease and associated with a high mortality rate." | ( Cao, X; Guo, X; Han, Q; Jin, Y; Li, Q; Li, S; Liu, J; Liu, Y; Ren, G; Sun, W; Wang, X; Zhao, H, 2023) |
| "Fibrosis is an important phenomenon as it can occur early in the pathogenesis of asthma; it may be associated with disease severity and resistance to therapy." | ( Pawliczak, R; Wieczfinska, J, 2023) |
| "Cardiac fibrosis is an important pathological change after myocardial infarction (MI)." | ( Hu, H; Huang, J; Li, W; Sun, K; Zhang, B; Zhang, S, 2023) |
| "Fibrosis is a pathological condition that is characterized by an abnormal buildup of extracellular matrix (ECM) components, such as collagen, in tissues." | ( Han, SH; Kang, ES; Ko, JY; Park, JH; Yoo, KH, 2023) |
| "Pulmonary fibrosis is an interstitial lung disease caused by various factors such as exposure to workplace environmental contaminants, drugs, or X-rays." | ( Chao, J; Chen, M; Jiang, W; Long, M; Luo, W; Sun, Y; Wang, J; Wang, S; Yuan, M; Zhang, W; Zhou, Y, 2023) |
| "Pancreatic fibrosis is characterized by the activation of pancreatic stellate cells leading to the expression of smooth muscle actin (α-SMA)." | ( Das, P; Dash, NR; Goswami, P; Gunjan, D; Mohta, S; Saraya, A; Singh, N, 2023) |
| "Fibrosis is a response to ongoing cellular injury, disruption, and tissue remodeling, the pathogenesis of which is unknown, and is characterized by extracellular matrix deposition." | ( Jiao, L; Jin, C; Liu, J; Tian, M; Yang, S; Yao, W; Zhang, S; Zhou, F; Zhou, R, 2023) |
| "Cardiac fibrosis is the main pathological change in the end stage of cardiovascular diseases." | ( Ding, Y; Liu, Y; Peng, Y; Wang, H; Wang, Y; Zhang, X; Zhang, Y, 2023) |
| "Hepatic fibrosis is the first stage of liver disease, and can progress to a chronic status, such as cirrhosis or hepatocellular carcinoma." | ( Azamov, B; Hur, J; Lee, C; Lee, KM; Muradillaeva, S; Shim, WS; Song, P, 2023) |
| "Liver fibrosis is a reversible pathological process and a wound healing response to liver injury." | ( Chen, C; Chen, P; Gu, Y; Li, S; Liu, F; Wang, L; Wang, R; Wang, S; Yuan, Y, 2023) |
| "Pancreatic fibrosis is the hallmark of chronic pancreatitis (CP), which is associated with microcirculatory disturbance." | ( Li, J; Liu, H; Lu, Y; Ren, G; Wang, D; Yang, B; Yang, S; Yao, D; Zhang, T, 2023) |
| "Liver fibrosis is a worldwide challenge of health issue." | ( Guo, FY; Jin, CH; Lian, LH; Lin, YC; Nan, JX; Wu, YL; Yang, HX, 2023) |
| "Fibrosis is shared in multiple diseases with progressive tissue stiffening, organ failure and limited therapeutic options." | ( Accorsi, L; Arnaud, GF; Bergamini, V; Chiavelli, C; Delnevo, A; Dominici, M; Ferrari, A; Ganzerli, F; Marra, C; Petrachi, T; Portone, A; Resca, E; Rovati, L; Veronesi, E, 2023) |
| "Tubulointerstitial fibrosis is considered the final convergent pathway of progressive chronic kidney diseases (CKD) regardless of etiology." | ( Chen, X; Ding, ZY; Ge, C; Jin, G; Kuang, D; Li, P; Li, Z; Liang, H; Liu, J; Liu, L; Mo, J; Pan, Y; Tang, X; Wang, W; Xu, G; Yuan, C; Zhang, B; Zhang, Q; Zhang, W; Zhang, X, 2023) |
| "Pulmonary fibrosis is a debilitating and life-limiting lung condition in which the damage- response mechanisms of mixed-population cells within the lungs go awry." | ( Cash, E; Goodwin, AT; Tatler, AL, 2023) |
| "Renal fibrosis is the final manifestation of chronic kidney disease (CKD); its prevention is vital for controlling CKD progression." | ( Horikawa, M; Hou, H; Izumi, Y; Jono, H; Kakizoe, Y; Kuwabara, T; Mukoyama, M; Narita, Y; Saito, H, 2023) |
| "Renal fibrosis is an inevitable process in the progression of chronic kidney disease (CKD)." | ( Chang, J; Chang, Y; Fan, L; Gao, X; Liu, Z; Shimosawa, T; Xu, Q; Yang, F; Zhang, C, 2023) |
| "Myocardial fibrosis is common in DMD." | ( Crum, K; George-Durrett, K; Kasten, J; Markham, LW; Raucci, FJ; Slaughter, JC; Soslow, JH; Sunthankar, SD, 2023) |
| "Intestinal fibrosis is a prevalent complication of Crohn's disease (CD), characterized by excessive deposition of extracellular matrix (ECM), and no approved drugs are currently available for its treatment." | ( Dai, Y; Mu, K; Wei, Z; Wu, X; Xue, X; Zeng, X, 2023) |
| "Liver fibrosis is a global health problem, and studying its development provides important information to address its treatment." | ( de Sánchez, VC; de Vaca, RP; Domínguez-López, M; Guerrero-Celis, N; Rodríguez-Aguilera, JR; Velasco-Loyden, G, 2023) |
| "Fibrosis is a severe complication of chronic kidney disease (CKD)." | ( Abramicheva, PA; Kazakov, EP; Pevzner, IB; Plotnikov, EY; Popkov, VA; Semenovich, DS; Sokolov, IA; Zorov, DB; Zorova, LD, 2023) |
| "Atrial fibrosis is a major factor of atrial fibrillation (AF)." | ( Cai, X; Li, M; Liang, Z; Yang, W; Zhong, Y, 2023) |
| "Renal interstitial fibrosis is the primary pathological basis for the progression and development of various chronic kidney diseases, ultimately leading to renal failure." | ( Duan, Q; Peng, X; Wang, J; Wang, Z; Xia, F, 2023) |
| "Cardiac fibrosis is known as the expansion of the cardiac interstitium through excessive deposition of extracellular matrix proteins; this process is performed by a multifunctional cell known as the cardiac fibroblast." | ( Bolívar, S; Castellar-Lopez, J; Mendoza-Torres, E; Monterroza-Torres, J; Pérez-Cantillo, M; Vásquez-Trincado, C, 2023) |
| "Renal fibrosis is the final stage of most progressive kidney diseases." | ( Naas, S; Schiffer, M; Schödel, J, 2023) |
| "Renal fibrosis is a pathologic process that leads to irreversible renal failure without effective treatment." | ( Hong, Y; Li, Y; Liu, Q; Long, H; Luo, C; Tao, D; Wang, S; Xu, Z; Zeng, Y; Zheng, Z, 2023) |
| "Myocardial fibrosis is an underlying cause of many cardiovascular diseases." | ( Du, Y; Lan, B; Wang, B; Wang, H; Xie, H; Zhang, S, 2023) |
| "Hepatic fibrosis is a common pathological process in many chronic liver diseases." | ( Dong, F; Song, D; Tian, H; Wu, H; Wu, W; Zeng, J; Zhang, L, 2023) |
| "In conclusion, BM fibrosis is a novel mechanism mediating nonresponse to CD19-directed CAR T-cell therapy in B-ALL." | ( Alnemri, A; Anil, AE; Anil, J; Baumgartner, M; Gebre, K; Grupp, SA; Lockhart, B; Lytle, A; McFerran, J; Pillai, V; Rheingold, SR, 2023) |
| "Renal fibrosis is a common pathway leading to progressive renal function loss in various forms of chronic kidney disease." | ( Chang, MY; Chen, KH; Hsu, HH; Hung, CC; Ko, YC; Yang, CW; Yang, HY, 2024) |
| "Cardiac fibrosis is the uncontrolled accumulation of extracellular matrix proteins, which can exacerbate the progression of heart failure, and there are currently no drugs approved specifically to target matrix accumulation in the heart." | ( Nichols, W; Richardson, WJ; Watts, KM, 2023) |
| "Fibrosis is an unbalanced deposition of extracellular matrix components responsible for scar tissue formation with consequent tissue and organ impairment." | ( Corano Scheri, K; Fawzi, AA; Hsieh, YW; Jeong, E, 2023) |
| "Cardiac fibrosis is one of the top killers among fibrotic diseases and continues to be a global unaddressed health problem." | ( Barczyk-Woznicka, O; Bobis-Wozowicz, S; Cathomen, T; Ferdek, PE; Fic, K; Hammad, R; Kusiak, AA; Litewka, JJ; Madeja, Z; Nit, K; Paw, M; Piejko, M; Sarna, M; Stopa, KB; Wnuk, D; Zuba-Surma, E, 2023) |
| "Renal fibrosis is the final development pathway and the most common pathological manifestation of chronic kidney disease." | ( Aji, R; Feng, W; Gao, WQ; Gui, L; Li, L; Li, X; Liu, C; Ma, C; Ni, L; Rao, H; Wang, Z; Xu, J; Xu, Y; Zhang, W; Zhu, Y, 2023) |
| "Hepatic fibrosis is a progressive pathological process involving the exhaustion of hepatocellular regenerative capacity and ultimately leading to the development of cirrhosis and even hepatocellular carcinoma." | ( Cheng, Z; Friess, H; Hartmann, D; Hüser, N; Kaufmann, B; Mogler, C; Schmid, RM; von Figura, G; Wang, B; Yin, Y; Zhong, S, 2023) |