Infrequent or difficult evacuation of FECES. These symptoms are associated with a variety of causes, including low DIETARY FIBER intake, emotional or nervous disturbances, systemic and structural disorders, drug-induced aggravation, and infections.
| Excerpt | Reference |
|---|
| "Chronic constipation is not a simple problem." | ( Benson, JA, 1975) |
| "Although constipation is a well-known side effect of calcium channel blockers such as verapamil, this side effect has not been evaluated in a quantitative manner." | ( Cohen, S; Krevsky, B; Maurer, AH; Niewiarowski, T, 1992) |
| "Chronic constipation is probably the most common symptom resulting in a referral of patients for a dynamic radiologic investigation of the GI tract." | ( Piloni, V, 1991) |
| "Severe constipation is a debilitating concomitant of complete traumatic thoracic spinal cord injury." | ( Bradley, WE; Downey, N; Glick, ME; Haldeman, S; Hoehler, F; Meshkinpour, H, 1984) |
| "Meconium constipation is observed in a number of foals during every foaling period." | ( van Wuijckhuise-Sjouke, LA, 1984) |
| "Functional constipation is not a life-threatening disease, but as a chronic state it worries the patient and causes him discomfort and often leads him to self-medication with potentially dangerous drugs." | ( Goffin, H; Hanck, AB, 1982) |
| "Constipation is a common problem during pregnancy." | ( Jaquenoud, E; Müller, M, 1995) |
| "Chronic functional constipation is common in childhood." | ( Heyman, MB; Seth, R, 1994) |
| "Slow transit constipation is notoriously difficult to treat." | ( Klauser, AG; Mühldorfer, BE; Müller-Lissner, SA; Voderholzer, WA; Wenzel, G, 1995) |
| "Management of constipation is frequently poor, and considerable research effort is needed into both the more effective use of current treatments and the development of new therapies." | ( Sykes, NP, 1994) |
| "Slow transit constipation is associated with abnormalities of the substance P content of the enteric nervous system of mucosa and submucosa." | ( Klauser, AG; Müller-Lissner, SA; Riepl, RL; Schindlbeck, NE; Tzavella, K; Voderholzer, WA, 1996) |
| "Constipation is a problem frequently encountered during pregnancy as is excessive weight gain." | ( Croce, P; Dedè, A; Signorelli, P, 1996) |
| "Constipation is an ailment encountered often in elderly people." | ( Blaut, M; Kleessen, B; Sykura, B; Zunft, HJ, 1997) |
| "Chronic constipation is a common problem in children." | ( Doig, C; Miller, V; Odeka, EB; Sagher, F, 1997) |
| "Acute and chronic constipation are common conditions." | ( Barloon, TJ; Lu, CC, 1997) |
| "Chronic constipation is a common clinical condition that frequently does not respond to routine therapeutic measures." | ( Davis, RH; Eaker, EY; Sninsky, CA; Verne, GN, 1997) |
| "Chronic idiopathic constipation is likely to be a heterogeneous condition." | ( Anand, P; Knowles, C; Pilot, MA; Raethjen, J; Warner, G; Williams, N, 1997) |
| "Constipation is not an infrequent side effect complained of by patients taking calcium channel blockers." | ( Annese, V; Bassotti, G; Calcara, C; Fiorella, S; Morelli, A; Roselli, P, 1998) |
| "Constipation is a frequent cause of distress in advanced cancer." | ( Balachandran, P; Kumar, KS; Rajagopal, MR; Ramesh, PR; Warrier, PK, 1998) |
| "Constipation is a common condition affecting millions of people throughout the world." | ( Chung, BD; Parekh, U; Sellin, JH, 1999) |
| "Chronic constipation is one of the most common disorders in Western countries and despite numerous clinical, pathophysiologic, and epidemiologic studies its cause is still unclear." | ( Adamidis, D; Constantopoulos, A; Messaritakis, J; Nikolara, R; Roma, E, 1999) |
| "Constipation is a common symptom in cancer patients, especially in those who are receiving opioid analgesics for pain." | ( Bruera, E; Daeninck, PJ, 1999) |
| "Opioid-related constipation is one of the most frequent side effects of chronic pain treatment." | ( Hartmann, M; Kath, R; Meissner, W; Reinhart, K; Schmidt, U, 2000) |
| "Constipation is the most common chronic adverse effect of opioid pain medications in patients who require long-term opioid administration, such as patients with advanced cancer, but conventional measures for ameliorating constipation often are insufficient." | ( Foss, JF; Karrison, T; Moss, J; O'Connor, M; Osinski, J; Roizen, MF; Yuan, CS, 2000) |
| "Constipation is a risk factor of colorectal cancer." | ( Hase, T; Meguro, S; Sakata, T; Shimotoyodome, A; Tokimitsu, I, 2000) |
| "Constipation is probably the result of the volvulus." | ( Boddy, SA; Capps, S; Samuel, M, 2000) |
| "Constipation is the most frequent adverse event, with a higher incidence of transient constipation in alosetron-treated patients, typically occurring in the first month of treatment." | ( Chey, WY; Dukes, GE; Harding, J; Heath, AT; Hunt, CM; McSorley, DJ; Washington, MK; Wolfe, SG, 2001) |
| "Constipation is an expected side effect of opioid use and as such should be treated prophylactically." | ( Thorpe, DM, 2001) |
| "Constipation is a common side-effect of opioid therapy; in addition to their analgesic effect, opioids reduce intestinal secretion and motility with an increase in whole-gut transit time." | ( Evans, BK; Hawkes, ND; Lewis, SJ; Rhodes, J; Richardson, C; Thomas, GA, 2001) |
| "However, constipation is a major adverse effect that often detracts from the patient's quality of life." | ( Hoshi, S; Inagaki, K; Nabeshima, T; Nakao, M; Nishida, M; Niwa, T; Yamada, K, 2002) |
| "Constipation is common in patients with PSS." | ( Chen, DY; Chen, YH; Hsieh, TY; Lan, JL; Lin, WY; Wang, SJ, 2002) |
| "Refractory constipation is a common GI complaint seen by physicians in all practice settings." | ( Davis, RH; Eaker, EY; Gordon, JM; Robinson, ME; Sninksy, CA; Verne, GN, 2003) |
| "opioid-induced constipation is caused by linkage of the opioid to opioid receptors in the bowel and the central nerve system." | ( Klaschik, E; Nauck, F; Ostgathe, C, 2003) |
| "Constipation is mentioned occasionally as a possible tobacco withdrawal symptom, but no systematic data have been published on this issue." | ( Gillison, F; Hajek, P; McRobbie, H, 2003) |
| "Constipation is one of the more frequently occurring adverse effects associated with opioid therapy." | ( Markowitz, J; Schein, J; Staats, PS, 2004) |
| "Constipation is a common problem after reconstructive surgery for anorectal malformations." | ( Osatakul, N; Patrapinyokul, S; Sangkhathat, S, 2004) |
| "Chronic constipation is a common gastrointestinal disorder." | ( Chey, WD; Fordham, F; Guella, M; Johanson, JF; Lembo, AJ; Nault, B; Novick, JS; Tougas, G; Wald, A, 2004) |
| "Constipation is one of the most common gastrointestinal conditions with limited effective treatment options." | ( Johanson, JF, 2004) |
| "Chronic constipation is a common, persistent disorder with limited effective treatment options." | ( Boeckxstaens, G; Dzieniszewski, J; Fordham, F; Haeck, P; Hugot-Cournez, S; Kalinin, A; Kamm, MA; Minushkin, ON; Müller-Lissner, S; Nault, B; Tack, J; Talley, NJ, 2005) |
| "Symptoms of constipation are commonly seen in medical practice." | ( Talley, NJ, 2005) |
| "Constipation is a common complication of amyotrophic lateral sclerosis (ALS), especially as the disease progresses." | ( Fu, A, 2005) |
| "Constipation is associated with striking changes in the faecal flora, intestinal permeability and the systemic immune response." | ( Khalif, IL; Konovitch, EA; Maximova, ID; Quigley, EM, 2005) |
| "Chronic constipation is a highly prevalent disorder that is associated with significant direct and indirect costs and has substantial impact on patient quality of life." | ( Cash, BD; Chey, WD, 2005) |
| "Constipation is a common pediatric problem." | ( , 2006) |
| "Constipation is considered an expected side effect with chronic opioid use." | ( Logemann, C; Swegle, JM, 2006) |
| "Chronic constipation is a common and costly health problem occurring in approximately 4." | ( Chagan, L; Rivkin, A, 2006) |
| "Chronic constipation is a widespread condition." | ( Jordan, CC; Kamm, MA; Kienzle-Horn, S; Peil, H; Schuijt, C; Vix, JM, 2007) |
| "Infant constipation is a frequent condition in formula-fed infants." | ( Chao, HC; Vandenplas, Y, 2007) |
| "Constipation is the most common adverse event with alosetron treatment." | ( Ameen, V; Carter, EG; Gordon, SH; Heath, AT; Krause, R; Perschy, T; West, M, 2007) |
| "Constipation is a worldwide problem that affects many children." | ( Benninga, MA; Di Lorenzo, C; Liem, O; Mousa, HM, 2007) |
| "A rare cause of constipation is Hirschsprung disease (HD)." | ( Benninga, MA; Boeckxstaens, GE; de Lorijn, F, 2007) |
| "Constipation is a particularly problematic and common side effect of opioid pharmacology." | ( Friedman, D; Jahdi, M; Rim, F; Shaiova, L, 2007) |
| "Cancer-related constipation is common and a significant detractor from patient quality of life." | ( Thomas, J, 2007) |
| "Constipation is common in the elderly because of age-related physiologic changes and polypharmacy." | ( Ginsberg, DA; Josephson, KL; Phillips, SE; Wallace, J, 2007) |
| "Constipation is a frequent adverse effect of antipsychotics and adjunctive psychotropics, which can be severe and may lead to life-threatening paralytic ileus." | ( Kashima, H; Suzuki, T; Uchida, H; Watanabe, K, 2007) |
| "Although constipation is a common and usually benign side effect of treatment with clozapine, this case-report highlights the consequences of undertreated and unrecognized marked constipation progressing to severe bowel obstruction (a complication which deserves more attention because it can lead to hospitalization and might be potentially fatal)." | ( Borella, D; De Luca, P; La Pesa, M; Pelizza, L, 2007) |
| "Chronic constipation is associated with use of acetaminophen, aspirin and non-steroidal anti-inflammatory drugs." | ( Chang, JY; Locke, GR; Schleck, CD; Talley, NJ; Zinsmeister, AR, 2007) |
| "However, severe constipation is associated with time since diagnosis and severity of disease." | ( Krogh, K; Laurberg, S; Ostergaard, K; Sabroe, S, 2008) |
| "Constipation is a significant problem in patients taking morphine for cancer pain." | ( Droney, J; Gretton, S; Riley, J; Ross, J; Sato, H; Welsh, K, 2008) |
| "Constipation is one of the most frequent gastrointestinal symptoms." | ( Erckenbrecht, JF; Hinkel, U; Schuijt, C, 2008) |
| "Constipation is a common disease in children." | ( Dong, M; Li, ZH; Wang, ZF, 2008) |
| "Constipation is a common and distressing condition in patients with cancer, especially those taking opioid analgesics." | ( Byeon, JJ; Hawley, PH, 2008) |
| "Constipation is a distressing side effect of opioid treatment." | ( Chamberlain, BH; Cooney, GA; Israel, RJ; Karver, S; Kremer, AB; Slatkin, NE; Stambler, N; Thomas, J; Watt, CK, 2008) |
| "functional constipation is a prevalent problem within the western population." | ( Carmuega, E; De Paula, JA; Weill, R, 2008) |
| "Constipation is the most common gastrointestinal complication associated with opioid therapy in chronic pain patients, and also frequently occurs in sedated intensive care unit patients." | ( Chappell, D; Conzen, P; Rehm, M, 2008) |
| "Constipation is a common symptom in palliative care patients that can generate considerable suffering due to both unpleasant physical symptoms and psychological preoccupations that may arise." | ( Clemens, KE; Klaschik, E, 2008) |
| "Chronic constipation is highly prevalent, reduces patients' quality of life, and imposes a significant health care burden on society." | ( Lacy, BE; Levy, LC, 2008) |
| "Constipation is a common gastrointestinal disease affecting 2-27% of the population in Western hemisphere." | ( Fried, M; Pohl, D; Tutuian, R, 2008) |
| "Constipation is a common complaint in children and early intervention with oral laxatives may improve complete resolution of functional constipation." | ( Benninga, MA; Berger, MY; Pijpers, MA; Tabbers, MM, 2009) |
| "Constipation is clearly a major issue in the elderly and these new, emerging strategies will hopefully improve the quality of life and relieve the symptoms of constipation in this population." | ( Kapoor, S, 2008) |
| "Symptoms of constipation are extremely common, especially in the elderly." | ( Chan, HC; Du, JY; Ko, WH; Pan, A; Ruan, YC; Yang, ZH; Yu, HJ; Zhou, WL, 2008) |
| "Constipation is one of the most frequent adverse drug reactions occurring in hospital inpatients." | ( Davies, EC; Green, CF; Mottram, DR; Pirmohamed, M, 2008) |
| "Constipation is a common problem in children." | ( Alles, MS; Benninga, MA; Decates, TS; Fiselier, TJ; Kimpen, JL; Kokke, FT; Scholtens, PA; Tolboom, JJ, 2008) |
| "Chronic constipation is a common condition that affects up to 27% of the population." | ( Müller-Lissner, S; Tack, J, 2009) |
| "Unfortunately, constipation is a common adverse effect associated with opioid use." | ( Arpino, PA; Thompson, BT, 2009) |
| "Opioid-induced constipation is a significant problem particularly for end stage cancer patients, methadone users, patients suffering from chronic pain as well as surgical patients." | ( Cannom, RR; Mason, RJ, 2009) |
| "Constipation is a common problem in children, with childhood prevalence estimated at between 1 and 30%." | ( Catto-Smith, AG; Chase, JW; Clarke, MC; Gibb, S; Hutson, JM; King, SK; Robertson, VJ; Southwell, BR; Sutcliffe, J, 2009) |
| "Constipation is reported in 52% of people with advanced malignancy." | ( Ahmedzai, SH; Boland, J, 2007) |
| "Constipation is highly prevalent, with approximately 12 million general practitioner prescriptions for laxatives in England in 2001." | ( Barclay, M; Frizelle, F, 2007) |
| "Chronic constipation is common among nursing home residents." | ( Beyens, G; Camilleri, M; Kerstens, R; Robinson, P; Vandeplassche, L, 2009) |
| "Constipation is one of the most common gastrointestinal complications suspected to degrade the quality of life in diabetic patients." | ( Inui, A; Satoh, Y; Ueno, N, 2010) |
| "Constipation is a common problem associated with opiates and opioid compounds used for the treatment of pain and other medical conditions, and can influence patient quality of life." | ( Baker, DE, 2009) |
| "Constipation is a significant medical issue in CF and was associated with low total fat absorption and a history of meconium ileus." | ( Beek, FJ; Froeling, SP; Houwen, RH; Kokke, FT; van der Doef, HP; Woestenenk, JW, 2010) |
| "Constipation is a frequent adverse drug event seen with opioids, the first-line therapy for sickle cell pain crises." | ( Fan, L; Kelleher, KJ; O'Brien, SH, 2010) |
| "Opioid-induced constipation is common in palliative care and causes considerable distress to patients taking opioids." | ( Kyle, G, 2009) |
| "Opioid-induced constipation is a common adverse event in patients with advanced illness and has a significant negative impact on patients' quality of life and costs." | ( Earnshaw, SR; Iyer, S; Klok, RM; McDade, C, 2010) |
| "Chronic constipation is a frequently reported medical disorder that reduces patients' quality of life and imposes a significant economic burden on the health care system." | ( Crowell, MD; Lacy, BE; Loew, B, 2009) |
| "Constipation is a significant manifestation of a number of psychological disorders." | ( El-Tawil, AM, 2010) |
| "Constipation is a common pathological condition in pregnant women; nevertheless, its possible association with structural birth defects (i." | ( Acs, N; Bánhidy, F; Czeizel, AE; Puhó, EH, 2010) |
| "Constipation is common in advanced cancer." | ( Clark, K; Currow, DC; Urban, K, 2010) |
| "Functional constipation is the most common cause of constipation in Indian children." | ( Khanna, V; Poddar, U; Yachha, SK, 2010) |
| "Constipation is a common gastrointestinal disorder often related to the food diet." | ( de Candia, S; Lavermicocca, P; Lonigro, SL; Orlando, A; Riezzo, G; Russo, F; Valerio, F, 2010) |
| "Constipation is a common problem in children with severe disabilities." | ( Benninga, MA; Calis, EA; Evenhuis, H; Penning, C; Tibboel, D; Veugelers, R; Willemsen, SP, 2010) |
| "Overall constipation is a rarely studied or reported side effect of antipsychotic medication." | ( Bernagie, C; De Hert, M; Dockx, L; Hudyana, H; Leucht, S; Peuskens, J; Sweers, K; Tack, J, 2011) |
| "Constipation is a common clinical problem." | ( Lee-Robichaud, H; Morgan, J; Nelson, RL; Thomas, K, 2010) |
| "Constipation is the most common gastrointestinal complaint all over the world and it is a risk factor of colorectal cancer." | ( Afolayan, AJ; Sunmonu, TO; Wintola, OA, 2010) |
| "Constipation is a common gastrointestinal symptom in Korea as well as in Western countries." | ( Chang, KJ; Park, JY; You, JS, 2010) |
| "Constipation is a common problem for advanced cancer patients, and is generally inadequately treated." | ( Casuccio, A; Ferrera, P; Mercadante, S, 2011) |
| "Chronic constipation is a common digestive problem in North America, with significant psychosocioeconomic implications." | ( Rao, SS; Singh, S, 2010) |
| "Constipation is a common adverse event of treatment with opioids for chronic non-malignant pain and may result in a considerable reduction in health-related quality of life." | ( Hopp, M; Leyendecker, P; Rentz, AM; van Hanswijck de Jonge, P, 2011) |
| "Opioid-induced constipation is a major side effect of the use of opioid pain medications in a palliative care population." | ( Boyd, TA; Rotshteyn, Y; Yuan, CS, 2011) |
| "Constipation is common in palliative care; it can generate considerable suffering due to the unpleasant physical symptoms." | ( Candy, B; Drake, R; Goodman, ML; Jones, L; Tookman, A, 2011) |
| "While constipation is a common symptom in Korea, there are no existing treatment guidelines." | ( Choi, CH; Choi, MG; Choi, SC; Huh, KC; Jung, SA; Myung, SJ; Park, MI; Shin, JE; Sohn, CI, 2011) |
| "Constipation is a common complaint seen in the emergency department for which patients will try many different remedies." | ( Desai, Y; Orledge, J, 2010) |
| "Chronic constipation is a highly debilitating condition, affecting a significant proportion of the community." | ( Spencer, NJ; Zarate, N, 2011) |
| "DIOS and constipation are frequently seen in cystic fibrosis patients, especially later in life; genetic, dietary, and other associations have been explored." | ( Houwen, RH; Kokke, FT; van der Doef, HP; van der Ent, CK, 2011) |
| "Constipation is thought to be common, and a potential serious side-effect, which has received little attention in recent literature." | ( Bernagie, C; De Hert, M; Dockx, L; Leucht, S; Peuskens, B; Peuskens, J; Sweers, K; Tack, J; Van de Straete, S; Wampers, M, 2011) |
| "Constipation is highly prevalent, with approximately 12 million general practitioner prescriptions for laxatives in England in 2001." | ( Mueller-Lissner, SA; Wald, A, 2010) |
| "Constipation is a personal symptom and there is little correlation between subjective methods for assessment of constipation and objective evaluations, such as transit time and fecal loading." | ( Drewes, AM; Olesen, AE, 2011) |
| "Constipation is a common problem for adults and paediatric patients and can generate considerable suffering for patients due to both the unpleasant physical symptoms and psychological preoccupations that can arise." | ( Maydeo, A, 2010) |
| "Constipation is a common occurrence in formula-fed infants." | ( Alvarez, MM; Infante, DD; Miserachs, MM; Redecillas, SS; Segarra, OO, 2011) |
| "A case of severe constipation is described in a 75-year- old cancer patient receiving methadone for pain." | ( Papa, P; Turconi, L, 2011) |
| "Constipation is a frequent complaint, especially in women and the elderly." | ( , 2011) |
| "Functional constipation is common in childhood; diets in affluent industrialised countries may be a significant contributory factor as a result of inadequate fibre content." | ( Alder, N; Lambert, B; Shrestha, B; Sullivan, PB; Turton, L, 2012) |
| "Constipation is reported in 52% of people with advanced malignancy." | ( Ahmedzai, SH; Boland, J, 2010) |
| "Constipation is a common complication in critically ill children and it is occasionally resistant to the drugs typically used in treatment." | ( Botrán, M; García, A; González, R; López-Herce, J; Solana, MJ; Urbano, J, 2011) |
| "Constipation is prevalent in the cystic fibrosis (CF) population and yet there are few data demonstrating the effectiveness of currently used treatments." | ( Anderson, PJ; O'Brien, CE; Stowe, CD, 2011) |
| "Opioid-induced constipation is a severe complication affecting up to 90% of chronic pain patients treated with opioids, causing considerable suffering and non-adherence to treatment." | ( Bernardi, M; Hess, B; Klotz, HP, 2011) |
| "Constipation is a common functional gastrointestinal disorder that affects patients of all ages." | ( Liu, LW, 2011) |
| "Chronic constipation is a frequent complaint." | ( Pare, P, 2011) |
| " Opioid-induced constipation is a frequent side effect of opioid pain therapy due to opioid effects on the enteric nervous system, including gastric emptying and fluid absorption." | ( Bath, B; Bilsky, E; Burkart, J; Dallaire, B; Magiera, D; Phelps, M; Sadee, W; Webster, L; Yancey-Wrona, J; Yang, X, 2011) |
| "Constipation is one of the most common gastrointestinal complaints worldwide." | ( Back, HI; Chae, HJ; Chae, SW; Ha, KC; Hwang, MH; Im, YJ; Jeon, JY; Jeung, HW; Kim, DS; Kim, HR; Kim, JH; Kim, MG; Kim, SY; Lee, CU; Lee, GH; Lee, HY; Li, B; Oh, MR; Park, SH; Shin, SJ; So, BO; Sung, MS; Yoo, WH, 2012) |
| "Constipation is also a problem in patients not on opioids and more attention is required." | ( Bian, ZX; Cheng, CW; Kwok, AO; Tse, DM, 2013) |
| "Constipation is a highly prevalent disorder." | ( Crowell, M; Lacy, BE; Levenick, J, 2012) |
| "Refractory constipation is a more difficult situation with limited treatment options available." | ( Chan, AO, 2012) |
| "Constipation is a common and potentially fatal side effect of clozapine treatment." | ( Chukhin, E; Eronen, M; Hakko, H; Joffe, G; Putkonen, H; Raidma, M; Räsänen, P; Stenberg, JH; Takala, P; Terevnikov, V, 2013) |
| "Opioid-induced constipation is described, including features, mechanism, and management of the disorder." | ( Wein, S, 2012) |
| "Prevalence of constipation is high among senior hospitalized patients." | ( Jia, ML; Li, B; Xiang, DN; Yu, XF; Zhang, Y, 2012) |
| "Chronic constipation is a frequent condition often treated pharmacologically." | ( Müller-Lissner, S, 2013) |
| "Chronic constipation is a common disorder in the general population, with higher prevalence in the elderly, and is associated with worse quality of life and with greater health care utilization." | ( Cremonini, F; Gras-Miralles, B, 2013) |
| "Constipation is a common condition for which PEG 3350 is an established treatment and prucalopride has recently been approved for this indication." | ( Chera, D; Cinca, R; Gruss, HJ; Halphen, M, 2013) |
| "Constipation is one of the most common gastrointestinal complaints with a highly prevalent and often chronic functional gastrointestinal disorder affecting health-related quality of life." | ( Chen, J; Chen, P; Jia, P; Xiu, A; Zhan, Y; Zhang, J; Zhao, Y; Zhou, M, 2013) |
| "Indacaterol-induced constipation is an unusual event that could be accounted for the high intrinsic activity of the drug on colonic β3-adrenoreceptors, resulting in an inhibitory control of smooth muscle function and intestinal secretion." | ( Bellido, I; Carrascosa, MF; Lucena, MI; Salcines-Caviedes, JR, 2013) |
| "Opioid-induced constipation is commonly seen in pediatrics, especially at the end of life." | ( Baker, JN; Laubisch, JE, 2013) |
| "Constipation is a common side effect of opioid therapy." | ( Hammond, G; Kavanagh, S; Kwong, WJ; Okamoto, A; Upmalis, D; Yang, M, 2013) |
| "Chronic constipation is very frequent in the general population." | ( Antoniazzi, S; Carnovale, C; Clementi, E; Nisic, A; Pellegrino, P; Perrone, V; Pozzi, M; Radice, S, 2013) |
| "Chronic functional constipation is a common disorder in childhood." | ( Ejerskov Pedersen, C; Jønsson, IM; Krogh, K; Siggaard, C, 2013) |
| "Chronic constipation is one of the most common reasons for pediatric outpatient visits." | ( Chogle, A; Saps, M, 2013) |
| "Constipation is a major gastrointestinal motility disorder with clinical need for effective drugs." | ( Doihara, H; Itou, H; Kaku, H; Keto, Y; Kojima, R; Nozawa, K; Yokoyama, T, 2014) |
| "Constipation is a common medical problem and when standard laxatives fail it can be difficult to treat." | ( Ali, H; Thayalasekeran, S; Tsai, HH, 2013) |
| "Chronic constipation is a frequent pathological condition bearing relevant socioeconomic burdens, mainly due to uncertain management and unsatisfactory response to traditional laxatives." | ( Barbara, G; Bellacosa, L; Cogliandro, R; Cremon, C; De Giorgio, R; Stanghellini, V, 2014) |
| "Constipation is often characterized by slow colonic transit, but the relationship between colonic transit time (CTT) and symptoms is unclear." | ( Cools, M; Emmanuel, A; Kerstens, R; Vandeplassche, L, 2014) |
| "Opioid-induced constipation is common and debilitating." | ( Barker, PN; Chey, WD; Lappalainen, J; Sostek, M; Tack, J; Webster, L, 2014) |
| "Chronic constipation is frequent in children." | ( Garnier, P; Mathiex-Fortunet, H; Pienvichit, P; Simakachorn, N; Tongpenyai, Y; Treepongkaruna, S; Varavithya, W, 2014) |
| "Chronic constipation is a very common clinical problem with its prevalence of up to 14% in the general population." | ( Choi, SC; Hong, KS; Jung, KW; Kim, SE; Lee, BE; Lee, TH; Park, KS; Park, SY; Shin, JE, 2014) |
| "Because chronic constipation is frequently reported in children, the possibility that macrogol contributes to adrenal crisis should be taken in account." | ( de Martino, M; Del Greco, P; Iurato, C; Poggi, G; Ricci, F; Seminara, S; Stagi, S, 2014) |
| "Opioid-induced constipation is a major clinical problem." | ( Akbarali, HI; Dewey, WL; Inkisar, A, 2014) |
| "Dry mouth and constipation are the most frequently reported adverse events." | ( Brunocilla, E; Carini, M; De Nunzio, C; Gacci, M; Gravas, S; Novara, G; Oelke, M; Salvi, M; Schiavina, R; Sebastianelli, A; Serni, S; Tubaro, A, 2014) |
| "Constipation is an uncomfortable and common condition that affects many, irrespective of age." | ( Fedorak, RN; Paré, P, 2014) |
| "However the rate of constipation is higher for solifenacin." | ( Li, J; Li, P; Liu, B; Wang, Y; Wu, Y, 2014) |
| "Constipation is one of most frequent non-motor symptoms of Parkinson's disease (PD) and it may precede the clinical diagnosis of PD by years, with negative effects on quality of life." | ( Bautista, A; Haider, JM; Pagano, G; Tagliati, M; Tan, EE, 2015) |
| "Constipation is a frequent non-motor feature of Parkinson's disease (PD)." | ( Merello, M; Perez-Lloret, S; Rossi, M, 2015) |
| "Constipation is an extremely common problem in children, varying from mild and short-lived to severe and chronic." | ( Dominguez, ML; Garcia, L; Infante, JR; Moreno, M; Rayo, JI; Serrano, J, 2015) |
| "Constipation is a common gastrointestinal disorder characterized by symptoms such as straining, hard stool, and infrequent defecation." | ( Inaloo, S; Moezi, L; Pirsalami, F, 2015) |
| "Chronic constipation is a common problem in children." | ( Barnhart, DC; Rollins, MD; Russell, KW; Scaife, ER; Zobell, S, 2015) |
| "Constipation is a common cause of admission to hospital for disimpaction, as oral laxatives are often inadequate." | ( Hutson, JM; Jordan-Ely, J; Southwell, BR, 2015) |
| "Constipation is a common complication in patients with opioid therapy." | ( Bellin, F; Beutlhauser, T; Fritzsche, T; Reuter, E; Schäfer, M; Tafelski, S; West, C, 2016) |
| "Constipation is common in the palliative population." | ( Bharucha, A; Prichard, D, 2015) |
| "Chronic idiopathic constipation is a common disorder of the gastrointestinal tract that encompasses a wide profile of symptoms." | ( Fichna, J; Mosińska, P; Storr, M, 2015) |
| "The causes of constipation are mainly three: lifestyle related (functional constipation), disease related, and drug induced." | ( Capasso, R; Cirillo, C, 2015) |
| "Chronic constipation is a risk factor of inadequate bowel preparation for colonoscopy; however, no large clinical trials have been performed in this subgroup of patients." | ( Arena, M; Baccarin, A; Bargiggia, S; Fontana, P; Manes, G; Masci, E; Mazzoleni, G; Parente, F; Spinzi, G; Testoni, PA; Vailati, C, 2015) |
| "Constipation is a common and potentially serious side effect of oral opioids." | ( Hunold, KM; Platts-Mills, TF; Smith, SA, 2015) |
| "Constipation is a common adverse effect of opioids." | ( Ahmedzai, SH; Boland, JW, 2015) |
| "Constipation is a common problem in intensive care units." | ( de Azevedo, RP; Ferreira, EM; Freitas, FG; Machado, FR; Pontes de Azevedo, LC, 2015) |
| "Constipation is extremely common in patients with Parkinson's disease (PD) and has been described in PD animal models." | ( Ambrosi, G; Balestra, B; Blandini, F; Bonizzi, A; Cerri, S; Ferrigno, A; Ghezzi, C; Levandis, G; Pastoris, O; Rizzo, V; Siani, F; Vairetti, M; Vicini, R, 2015) |
| "Constipation is common in the general population and for those on opioids and/or who are suffering from advanced cancer." | ( Davis, M; Gamier, P, 2015) |
| "Opioid-induced constipation is a common side effect of opioid therapy that has been under-recognized and undertreated." | ( Gupta, A, 2015) |
| "Constipation is a disorder frequently complained about by patients in daily clinical practice." | ( Bassotti, G; Bellini, M; Gambaccini, D, 2016) |
| "Constipation is a prevalent comorbidity affecting ∼50% of patients with long-term opioid therapy." | ( Bellin, F; Beutlhauser, T; Denke, C; Fritzsche, T; Schäfer, M; Tafelski, S; West, C, 2015) |
| "Constipation is a common adverse effect in patients requiring long-term opioid therapy for pain control." | ( Baqai, A; Diwan, S; Giambrone, GP; Mehta, N; O'Connell, K, 2016) |
| "Constipation is a common complication of opioid therapy that contributes to substantial patient morbidity, decreased productivity, and opioid nonadherence." | ( Argoff, CE; Johnson, DA, 2015) |
| "Constipation is common and a significant problem in pregnant women." | ( Hayakawa, H; Kikkawa, F; Kotani, T; Mano, Y; Sumigama, S; Tsuda, H, 2016) |
| "Opioid-induced constipation is a major side effect that persists with long-term opioid use." | ( Akbarali, HI; Damaj, MI; Dewey, WL; Gade, AR; Grider, JR; Kang, M; Khan, F, 2016) |
| "Functional constipation is a common pediatric problem in general practice and even more so in pediatric gastroenterology clinics." | ( Mouterde, O, 2016) |
| "Refractory constipation is less common in primary care set up." | ( Poddar, U, 2016) |
| "Chronic constipation is a frequent complaint in daily clinical practice." | ( Bassotti, G; Bellini, M; Gambaccini, D, 2016) |
| "Constipation is a frequently overlooked side effect of clozapine treatment that can prove fatal." | ( Flanagan, RJ; Gaughran, F; Gomez, L; Lally, J; MacCabe, JH; Moore, S; Shirazi, A; Stubbs, B, 2016) |
| "Constipation is a common disorder in the general population and can be observed in healthy individuals." | ( Airinei, G; Alexandre, V; Benamouzig, R; Bertin, C; Boubaya, M; Bouchoucha, M, 2016) |
| "Constipation is a common and often debilitating condition in the elderly, which may be caused by underlying disease conditions, structural abnormalities in the bowel, and a variety of medications such as anticholinergics, antidepressants, and opiates." | ( Bridgeman, MB; Chokhavatia, S; Dixit, D; John, ES, 2016) |
| "Constipation is the most common nonpain symptom." | ( Ackermann, RJ; Baralatei, FT, 2016) |
| "Constipation is one of the most common gastrointestinal disorders with a prevalence up to 16." | ( Lee, HJ; Park, KS, 2016) |
| "Functional constipation is an important clinical problem among chidren all over the world." | ( Arslan, N; Bozkaya, Ö; Çirali, C; Ercal, D; Küme, T; Ülgenalp, A; Ulusoy, E, 2021) |
| "Constipation is present in 80% of children with corrected anorectal malformations, usually associated to rectal dilation and hypomotility." | ( Arredondo-García, JL; Lezama-Del Valle, P; Maza-Vallejos, J; Santos-Jasso, KA, 2017) |
| "Constipation is the most common GI symptom in patients with diabetes mellitus (DM)." | ( Carter, LA; Christie, J; Dietz-Lindo, KA; Hanfelt, J; Harrison, MS; Shahnavaz, N; Shroff, S; Srinivasan, S, 2017) |
| "Constipation is a common disorder in children." | ( Castillejo-DeVillasante, G; Closa-Monasterolo, R; Escribano, J; Ferré, N; Gispert-Llaurado, M; Luque, V; Theis, S; Zaragoza-Jordana, M, 2017) |
| "Chronic constipation is one of the most common gastrointestinal symptoms in patients with diabetes, and occurs more frequently than in healthy individuals." | ( Abraham, P; Prasad, VG, 2017) |
| "Functional constipation is very common with heterogeneous symptoms that have substantial impact on patient quality of life as well as medical resources which are rarely reported as life-threatening." | ( Chieng, JY; Hazizi, AS; Lim, YJ; Rosita, J, 2016) |
| "Constipation is a major untoward effect of opioids." | ( Bassotti, G; Breivik, H; Coffin, B; Drewes, AM; Eisenberg, E; Emmanuel, A; Laroche, F; Meissner, W; Morlion, B; Müller-Lissner, S, 2017) |
| "Constipation is a common complaint for people of all ages, with prevalence increasing with age and during pregnancy." | ( Bardsley, A, 2017) |
| "Chronic constipation is a highly common functional gastrointestinal disorder that adversely affects patient quality of life." | ( Asari, T; Fujimori, Y; Fushimi, N; Inoue, T; Isaji, M; Kobayashi, M; Kurooka, T; Nishibe, H; Onozato, T; Takeda, H; Takemura, M, 2017) |
| "Constipation is a common symptom in patients with advanced disease taking opioids." | ( McPherson, ML; Sera, L, 2018) |
| "Constipation is a common symptom affecting up to 30% of the Western population and is strongly associated with the presence of intestinal methanogens, which may directly inhibit motor activity." | ( Franceschi, F; Gasbarrini, A; Gnarra, M; Migneco, A; Ojetti, V; Petruzziello, C, 2017) |
| "Opioid-induced constipation is a frequent side-effect of opioid treatment, and standard interventions have limited or inconsistent efficacy." | ( Arjona Ferreira, JC; Hale, M; Reddy, J; Wild, J; Yamada, T, 2017) |
| "Constipation is one of the main and disabling nonmotor symptoms in Parkinson's disease (PD), with a prevalence ranging from 24." | ( Stocchi, F; Torti, M, 2017) |
| "Chronic constipation is one of the most common digestive diseases frequently observed in a clinical setting." | ( Kim, SJ; Park, KS, 2017) |
| "Opioid-induced constipation is a common problem associated with chronic use of opioid analgesics." | ( Sivaramakrishnan, G; Sridharan, K, 2018) |
| "Constipation is a common affliction which causes discomfort and affects the quality of life of affected individuals." | ( Liang, Y; Su, Q; Wang, D; Wu, D; Yan, Z; Yin, H; Yin, J, 2018) |
| "Constipation is a common but potentially life-threatening adverse effect of clozapine that is understudied." | ( Bhat, SM; Chougule, A; Praharaj, SK; Sharma, PSVN, 2018) |
| "Functional constipation is a clinical problem with an incompletely understood etiology." | ( Arslan, N; Cıralı, C; Kume, T; Ulusoy, E, 2018) |
| "Constipation is a common symptom frequently compromising the quality of daily life." | ( Inoue, R; Numata, T; Okada, Y; Sato-Numata, K, 2018) |
| "Chronic constipation is a functional gastrointestinal disease that is detrimental to the quality of patient life." | ( Jang, SH; Yang, DK, 2018) |
| "Chronic constipation is a common gastrointestinal condition associated with intestinal inflammation and considerably impaired quality of life, affecting about 20% of Americans." | ( Honvoh, G; Kim, H; Mertens-Talcott, SU; Sirven, MA; Talcott, ST; Tekwe, CD; Venancio, VP, 2018) |
| "Opioid-induced constipation is a consequence of the action of opioids on their receptors in the gastrointestinal tract." | ( De Giorgio, R; Del Vecchio, S; Downes, TJ; Farmer, AD; Holt, CB; Ruggeri, E, 2018) |
| "Opioid-induced constipation is a clinically relevant side effect and a cause of potentially avoidable drug-related hospital admissions." | ( Bouvy, M; Bruin, F; Hek, K; Langendijk, P; Lieshout, JV; Teichert, M; Verduijn, M, 2019) |
| "Constipation is the most common chronic adverse effect of opioid pain medications in patients who require long-term opioid administration, such as patients with advanced cancer, but conventional measures for ameliorating constipation often are insufficient." | ( Moss, J, 2019) |
| "Constipation is a well known side effect of clozapine treatment." | ( Ingimarsson, O; MacCabe, JH; Sigurdsson, E, 2018) |
| "Constipation is a common problem during clozapine treatment which can progress to full-blown ileus which can be fatal." | ( Ingimarsson, O; MacCabe, JH; Sigurdsson, E, 2018) |
| "Constipation is an acute or chronic illness attributed to various causes, ranging from lifestyle habits to side effects of a disease." | ( Choi, JY; Hong, JT; Hwang, DY; Kim, HR; Kim, JE; Lee, ML; Park, JJ; Song, BR; Song, HK; Yun, WB, 2019) |
| "Constipation is a common condition among older people, particularly among people living in nursing homes, and the use of drugs such as opioids is one of many factors that contribute to its high prevalence." | ( Gustafsson, M; Isaksson, U; Lämås, K; Lövheim, H; Sandman, PO, 2019) |
| "Unfortunately, constipation is a common adverse effect of opioids." | ( Pergolizzi, JV; Raffa, RB; Taylor, R, 2019) |
| "Constipation is a common functional problem of the digestive system and may occur secondary to diet, drugs, endocrine diseases, metabolic diseases, neurological diseases, psychiatric disorders, or gastrointestinal obstruction." | ( Nam, K; Park, KS; Shin, JE, 2019) |
| "Constipation is a common symptom that may be primary (idiopathic or functional) or associated with a number of disorders or medications." | ( Bharucha, AE; Wald, A, 2019) |
| "Mood disorders and constipation are often comorbid, yet their shared etiologies have rarely been explored." | ( Bunnett, NW; Caron, MG; Carson, W; Del Colle, A; Israelyan, N; Jacobsen, JPR; Jensen, DD; Latorre, R; Law, K; Li, Z; Luna, RA; Madra, M; Margolis, KG; Park, Y; Rahim, R; Saurman, V; Xing, A, 2019) |
| "Constipation is a common functional gastrointestinal disorder and its etiology is multifactorial." | ( Chu, JR; Kang, SY; Kim, SE; Lee, SJ; Lee, YC; Sung, MK, 2019) |
| "Functional constipation is common in children and adults worldwide." | ( Benninga, MA; Camilleri, M; Di Lorenzo, C; Koppen, IJN; Vriesman, MH, 2020) |
| "Constipation is one of the most common gastrointestinal complaints." | ( Handa, O; Hirai, Y; Ishikawa, T; Itoh, Y; Kamada, K; Katada, K; Majima, A; Mizushima, K; Mukai, R; Naito, Y; Okayama, T; Suyama, Y; Takagi, T; Takayama, S; Uchiyama, K; Ushiroda, C, 2020) |
| "Opioid-induced constipation is frequently encountered in patients with cancer." | ( Shafi, MA, 2019) |
| "Constipation is common in patients with Parkinson's disease (PD)." | ( Abdollahi, M; Daniali, M; Mozaffari, S; Nikfar, S, 2020) |
| "Constipation is an important and highly prevalent predictor of inadequate bowel preparation during colonoscopy." | ( Dang, JT; Dang, TT; Karmali, S; Moolla, M; Shaw, A; Sultanian, R; Tian, C, 2021) |
| "Constipation is rare in sub-Saharan Africa, due to the high intake of dietary fiber." | ( Azandjeme, C; Cataria, H; Kpossou, AR; Séhonou, J; Sokpon, CNM; Vignon, RK, 2019) |
| "Enquiring about constipation is a simple and commonly used screening method for CIGH but its diagnostic accuracy has not previously been assessed." | ( Ellis, PM; Every-Palmer, S; Inns, SJ, 2020) |
| "Constipation is the most common adverse event (AE) of opioid therapy." | ( Argoff, CE; Blakesley, RE; Bochenek, W; Brenner, DM; Cash, BD; D'Astoli, P; Fox, SM; O'Dea, CR; Reasner, DS, 2020) |
| "Chronic constipation is a gastrointestinal functional disorder which affects patient quality of life." | ( Abdellaoui, A; Hajji, N; Jabri, MA; Rtibi, K; Sebai, H; Tounsi, H; Wannes, D, 2020) |
| "When opioid-induced constipation is treated with centrally acting opioid antagonists, there may be opioid withdrawal or aggravation of pain due to inhibition of μ-opioid analgesia." | ( Camilleri, M; Erwin, P; Murad, MH; Vijayvargiya, P, 2020) |
| "Constipation is a prevalent and burdensome gastrointestinal (GI) disorder that seriously affects the quality of human life." | ( Guan, X; Huang, J; Li, J; Li, S; Lin, B; Qian, L; Wang, Q; Zheng, Y, 2020) |
| "Chronic constipation is a common problem that substantially impacts the quality of life of patients and families, healthcare professionals, and resources." | ( Medina-Centeno, R, 2020) |
| "Opioid-induced constipation is a common problem in patients who have undergone surgery." | ( Di Lorenzo, C; Holstine, J; Samora, JB; Seilhamer, C, 2021) |
| "Constipation is a common side effect of opioid therapy." | ( Akashi, Y; Fumita, S; Gamoh, M; Harada, T; Imai, H; Kizawa, Y; Noriyuki, T; Okamoto, M; Tokoro, A, 2021) |
| "Constipation is a prevalent and distressing symptom affecting people with cancer." | ( LeFebvre, KB; Rogers, B; Wolles, B, 2020) |
| "Constipation is a common gastrointestinal complication during pregnancy." | ( Li, H; Xue, Y; Zhang, P, 2020) |
| "Constipation is a common problem in children with spastic cerebral palsy (sCP) with a prevalence that reaches 75%." | ( Bastawy, HA; Deifallah, SM; Hassanein, SMA, 2021) |
| "Constipation is one of the most prevalent gastrointestinal tract diseases." | ( Pegg, RB; Sun, R; Zhang, Q; Zhang, Y; Zhong, D; Zhong, G, 2021) |
| "Clozapine-induced constipation is a frequently overlooked side effect that can prove fatal." | ( Nagamine, T; Nakamura, M, 2021) |
| "Constipation is commonly treated with over-the-counter (OTC) products whose efficacy and safety remain unclear." | ( Brenner, DM; Rao, SSC, 2021) |
| "Functional constipation is a common childhood problem, with a prevalence of approximately 3% worldwide." | ( Bannerjii, R; Dheivamani, N; Mitra, M; Mukherjee, M; Thomas, W, 2021) |
| "Constipation is a common condition that affects individuals of all ages, and prolonged constipation needs to be prevented to avoid potential complications and reduce the additional stress on individuals with pre-medical conditions." | ( Chae, HJ; Chung, MJ; Hoang, TH; Jin, JS; Kang, IY; Lee, GH; Lee, HY; Park, SA, 2021) |
| "Constipation is commonly associated with diabetes." | ( Clemmensen, B; Gould, TW; Ha, SE; Heredia, DJ; Jin, B; Ro, S; Sanders, KM; Singh, R; Wei, L; Zogg, H, 2021) |
| "Opioid-induced constipation is the most prevalent adverse effect of opioid drugs." | ( Calò, G; Costanzini, A; De Giorgio, R; Malfacini, D; Neto, JA; Ruzza, C; Sternini, C; Sturaro, C, 2021) |
| "Constipation is a condition with a high prevalence rate worldwide and may occur in men and women of any age." | ( Chai, M; Chen, W; Li, X; Wang, G; Wang, L; Zhang, H; Zhao, J, 2021) |
| "Constipation is a frequent problem in children." | ( Abuhab, A; Crippa Júnior, MA; de Morais, MB; Toporovski, MS, 2021) |
| "Chronic constipation is a common gastrointestinal disorder that occurs in the elderly and in women." | ( Bai, X; Dong, X; Gao, P; Li, H; Liu, S; Shan, S; Yang, C, 2021) |
| "Constipation is a common, distressing complication in patients with cancer receiving palliative care." | ( Fuyuki, A; Higurashi, T; Honda, Y; Ichikawa, Y; Ishiki, H; Iwaki, M; Kasai, Y; Kessoku, T; Kobayashi, N; Kobayashi, T; Nakajima, A; Okubo, N; Oyamada, S; Ozaki, A; Taguri, M; Takeda, Y; Yoshihara, T, 2021) |
| "Hypertension and constipation are major hemodialysis complications." | ( Amano, A; Dohi, T; Fukushima, Y; Kaifu, K; Kasai, T; Kobayashi, T; Matsushita, S; Nagasawa, H; Okuma, T; Ono, S; Otsuka, T; Suzuki, Y; Ueda, S, 2021) |
| "Constipation is a gastrointestinal symptom with high incidence rate and large number of patients." | ( Bai, L; Gong, P; Guan, M; Liang, X; Liu, T; Lu, Y; Tong, L; Yi, H; Zhang, J; Zhang, L; Zhang, Z; Zhou, H; Zhou, X, 2021) |
| "Functional constipation is a gastrointestinal disorder prevalent around the world." | ( Chen, MH; Dai, N; Fang, XC; He, SX; Hou, XH; Li, YQ; Liu, L; Liu, S; Liu, XW; Liu, YL; Shen, XZ; Sun, MJ; Tian, A; Tian, ZB; Wang, XY; Wen, ZL; Wu, YD; Xiao, YL; Xu, H; Zeng, WZ, 2021) |
| "Functional constipation is a common pediatric GI disorder that is responsible for a significant portion of pediatric office visits each year." | ( Paul, A; Punati, J, 2021) |
| "Chronic constipation is a significant factor in poor bowel preparation for colonoscopy." | ( Esaki, M; Gotoda, T; Ichijima, R; Ikehara, H; Kusano, C; Ogura, K; Sugita, T; Suzuki, S, 2021) |
| "Constipation is a common gastrointestinal disorder." | ( Choi, CH; Choi, MG; Chung, WC; Jeon, SW; Kim, SY; Park, SJ; Yeon, SE, 2021) |
| "Chronic constipation is common among children with ASD and is associated with more severe hyperactivity, anxiety, irritability, and repetitive behaviors." | ( Bellomo, F; Boncoddo, M; Cucinotta, F; Mirabelli, S; Persico, AM; Ricciardello, A; Rossi, M; Scattoni, ML; Turriziani, L; Turturo, G, 2022) |
| "Constipation is a prevalent gastrointestinal complication in diabetes." | ( Brock, C; Jensen, SL; Liao, D; Sørensen, PS; Wegeberg, AM; Wigh, IMN; Zaugg, VS, 2022) |
| "Constipation is a major issue for 10-20% of the global population." | ( Boekhorst, J; Bos, R; Hageman, JHJ; Hartog, A; Nauta, A; Schoemaker, MH; Scholtens, PAMJ; Ten Haaf, D, 2022) |
| "Opioid-induced constipation is one of the heath problems with a negative impact on the quality of life." | ( Kocatepe, V; Talu, GK; Yildirim, D, 2022) |
| "Constipation is a very common medical condition worldwide, negatively affecting patients' quality of life and healthcare system." | ( Bian, ZX; Ma, Q; Sawadogo, WR; Wang, CZ; Yuan, CS, 2022) |
| "Constipation is a major health concern worldwide, requiring effective and safe treatment options." | ( Chai, M; Chen, W; Wang, G; Wang, J; Wang, L; Yu, Q; Zhang, H; Zhao, J, 2022) |
| "Constipation is one of the most frequent problems in cancer patients, and its etiology is multifactorial." | ( Dzierżanowski, T; Mercadante, S, 2022) |
| "Constipation is one of the most common gastrointestinal tract symptoms." | ( Geng, F; Hou, T; Li, B; Liu, X; Xia, P; Zhan, F; Zhang, Z, 2022) |
| "Constipation is characterized by infrequent bowel movements, hard and/or large stools, painful defecation, and faecal incontinence, and is often accompanied by abdominal pain." | ( Leszkowicz, J; Plata-Nazar, K; Szlagatys-Sidorkiewicz, A, 2022) |
| "Constipation is a common problem in sows and women during late pregnancy." | ( Bai, Y; Han, D; Kemp, B; Lian, S; Lu, D; Ni, D; Pi, Y; Soede, N; Wang, J; Wu, Y; Ye, H; Zhang, S; Zhao, J; Zou, X, 2022) |
| "Chronic constipation is a prevalent disorder that remains challenging to treat." | ( Dimidi, E; Drysdale, C; van der Schoot, A; Whelan, K, 2022) |
| "Constipation is a common gastrointestinal disease that reduces the quality of life and incurs considerable medical expenses." | ( Choi, Y; Ju, M; Kim, N; Lee, DH; Park, YS; Shin, CM; Yoon, H, 2022) |
| "Constipation is very pervasive all over the world." | ( Duan, J; Jiang, S; Li, W; Qian, D; Wang, Y; Yang, L; Zhang, Y, 2022) |
| "Slow transit constipation is an intractable constipation with unknown aetiology and uncertain pathogenesis." | ( Li, B; Li, M; Li, R; Li, W; Liu, Z; Luo, Y, 2022) |
| "Opioid-induced constipation is a common problem in critically ill children requiring sedation." | ( Crawley, L; Gillett, EL; Layes, CA; Schexnayder, SM, 2023) |
| "Opioid-induced constipation is a common problem in critically ill children requiring sedation." | ( Crawley, L; Gillett, EL; Layes, CA; Schexnayder, SM, 2023) |
| "Constipation is common after pelvic surgery, and studies suggest that surgeons underestimate the negative impact of constipation on patients." | ( Coughlin, AC; Dubois, B; Romanova, A; Woodbury, CF, 2023) |
| "Constipation is a common reason for children seeking medical care worldwide." | ( Farnaghi, F; Gholami, N; Hadeiy, SK; Hajipour, M; Hassanian-Moghaddam, H; Hosseini, A; Imanzadeh, F; Philips, S; Salimi, A; Sayyari, A; Zamani, N, 2023) |
| "Functional constipation is the most common form of constipation, and its exact aetiology is still unclear." | ( Arslan, B; Caliskan, M; Dogan, G; Elevli, M; Orenay-Boyacioglu, S, 2023) |
| "Refractory constipation is the most severe form of constipation, and its etiology remains unknown." | ( Chen, W; Dai, D; Li, B; Li, R; Liu, Z; Xu, S; Zhang, B, 2023) |
| "Constipation is a common functional gastrointestinal disorder, which needs more effective treatment approaches." | ( Lu, X; Wang, R; Zhang, S; Zhang, W; Zhao, L, 2023) |
| "Constipation is currently one of the most common gastrointestinal disorders, and its causes are diverse." | ( Chen, W; Guo, X; Liu, X; Wang, G; Wang, L; Zhang, C; Zhao, J, 2023) |
| "Constipation is frequent in critically ill patients, and potentially related to adverse outcomes." | ( Muttini, S; Palandri, C; Racagni, M; Umbrello, M; Venco, R, 2023) |