Neonatal Sepsis

Blood infection that occurs in an infant younger than 90 days old. Early-onset sepsis is seen in the first week of life and most often appears within 24 hours of birth. Late-onset occurs after 1 week and before 3 months of age.

Synonym
Neonatal Sepsis

Excerpt	Reference
"Neonatal sepsis is a serious condition, where an adequate empiric antibiotic treatment is crucial."	( Akselsen, AB; Sheth, CC; Veses, V, 2022)
"Neonatal sepsis is a serious and frequently lethal infection, often complicated by antimicrobial resistance (including ESBLs) in low- and middle-income countries (LMICs)."	( Darlow, CA; Hope, W, 2022)
"Neonatal sepsis is a serious bacterial infection of neonates, globally killing up to 680 000 babies annually."	( Da Costa, RMA; Darlow, CA; Das, S; Ellis, S; Farrington, N; Franceschi, F; Hope, W; Jimenez-Valverde, A; Johnson, A; Kolamunnage-Dona, R; McEntee, L; Neely, M; Piddock, LJV; Sharland, M; Unsworth, J, 2022)
"Neonatal sepsis is an underrecognized burden on health care systems throughout the world."	( Darlow, C; Das, S; Farrington, N; Greenberg, R; Hope, W; Hornik, C; Jimenez-Valverde, A; Johnson, A; McEntee, L; Schwartz, J; Unsworth, J, 2022)
"The incidence of neonatal sepsis is high, and the main pathogen is CoNS."	( Chen, PY; Dong, QY; Gong, XY; He, XR; Hu, JT; Li, W; Wang, T; Yang, YH; Yu, YQ, 2022)
"Neonatal sepsis is a major cause of morbidity and mortality with a higher burden from the low- and middle-income countries."	( Bathia, JN; Mukherjee, A; Mukherjee, M; Poddar, S, 2022)
"Neonatal sepsis is a leading cause of neonatal mortality."	( Beloum, N; Bognini, JD; Bojang, A; Bottomley, C; Camara, B; D'Alessandro, U; Danso, M; Darboe, S; Dondeh, BL; Edmond, SY; Franck, HS; Garba, Z; Getanda, P; Graves, S; Jagne, I; Jones, JC; Nakakana, UN; Nassa, WGJ; Ndure, E; Njie, Y; Roca, A; Rouamba, T; Sillah, F; Somé, AM; Tahita, MC; Tinto, H, 2023)
"Neonatal sepsis is a severe bacterial infection that can lead to life-threatening complications in newborns."	( Bajire, SK; Banerjee, S; Mithun, HK; Shastry, RP, 2023)
"Neonatal sepsis is defined as a systemic inflammatory response caused by a suspected or proven infection, occurring in the first month of life, and remains one of the main causes of morbidity and mortality in newborn and preterm infants."	( Araújo-Júnior, JX; Barreto, RSS; Bezerra Carvalho, MT; Bourguignon, JJ; Carvalho, AMS; da Silva-Júnior, EF; de Aquino, TM; Heimfarth, L; Lima, NT; Moreira, JCF; Pereira, EWM; Quintans, JSS; Quintans-Júnior, LJ; Schmitt, M, 2020)
"Neonatal sepsis is a major cause of morbidity and mortality."	( Greisen, G; Gupta, M; Jakobsen, JC; Korang, SK; Lausten-Thomsen, U; Nava, C; Safi, S, 2021)
"Neonatal sepsis is common, lethal, and hard to diagnose."	( Bengnér, J; Faresjö, M; Gäddlin, PO; Quttineh, M; Salomonsson, K, 2021)
"Neonatal sepsis is the cause of substantial morbidity and mortality."	( Sánchez, PJ; Shane, AL; Stoll, BJ, 2017)
"Neonatal sepsis is a major cause of mortality in the developing countries."	( Colah, RB; Desai, S; Ghosh, K; Martin, SL; Mukherjee, MB; Nanavati, R, 2019)
"Neonatal sepsis is a serious threat especially for preterm infants."	( Entleutner, K; Ernst, W; Fill Malfertheiner, S; Schlieckau, F; Schulz, D; Seelbach-Goebel, B, 2018)
"Neonatal sepsis is a major cause of infant mortality in developing countries because of delayed injectable treatment, making it urgent to develop noninjectable formulations that can reduce treatment delays in resource-limited settings."	( Ba, B; Behl, CR; Désiré, A; Gaudin, K; Gomes, M; Kauss, T; Langlois, MH; Malick, AW; Patel, IH; Phoeung, T; Unowsky, J; White, N, 2018)
"Neonatal sepsis is a serious condition leading to morbidity and mortality in neonates worldwide."	( Asci, A; Erkekoglu, P; Kocer-Gumusel, B; Surmeli-Onay, O; Yigit, S; Yurdakok, M, 2015)
"Neonatal sepsis is a leading cause of neonatal deaths in developing countries."	( Agarwal, A; Chadha, N; Gupta, N; Jaiswal, N; Kaur, H; Kaur, N; Kondel, R; Kumar, A; Malhotra, S; Shafiq, N; Singh, M; Thumburu, KK, 2016)
"Early diagnosis of neonatal sepsis is difficult because clinical signs are non-specific."	( Bastug, O; Gunes, T; Halis, H; Korkut, S; Kurtoğlu, S; Öztürk, A; Saraymen, B; Şen, A, 2016)
"Neonatal sepsis is a systemic inflammation occurring in neonates because of a proven infection within the first 28days of birth."	( Chen, T; Coppa, GF; Hansen, LW; Jacob, A; Khader, A; Nicastro, JM; Prince, JM; Wang, P; Yang, WL, 2017)

Excerpt	Reference
"Meropenem is increasingly used to treat neonatal sepsis."	( Hao, GX; Raza, MA; Shi, HY; Van Den Anker, J; Xu, HY; Yao, BF; Zhao, W, 2022)
"It is safe and effective to treat neonatal sepsis-related AKI with CRRT, which should be an effective measure for the treatment of sepsis-related AKI neonates."	( Cai, C; Gong, X; Hong, W; Qiu, G; Shen, Y, 2020)
"The clinical diagnosis and treatment of neonatal sepsis is highly complicated."	( Chauhan, N; Jain, U; Tiwari, S, 2017)
"Melatonin could be used in the treatment of neonatal sepsis in both preterm and full-term neonates beside the conventional treatment."	( El-Gendy, FM; El-Hawy, MA; Hassan, MG, 2018)
"Gentamicin for the treatment of neonatal sepsis is both feasible and effective in community-based settings and can be used as an alternative to the hospitalbased care in resource compromised settings."	( Agarwal, A; Chadha, N; Gupta, N; Jaiswal, N; Kaur, H; Kaur, N; Kondel, R; Kumar, A; Malhotra, S; Shafiq, N; Singh, M; Thumburu, KK, 2016)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	0 (0.00)	23.3326
1990's	0 (0.00)	12.5806
2000's	0 (0.00)	18.1394
2010's	118 (47.77)	28.8240
2020's	129 (52.23)	9.53

Drug	Relationship Strength	Studies	Trials
acetic acid	low	1	0
methane	low	1	0
lactic acid	low	4	0
niacinamide	medium	1	1
pleconaril	medium	2	2
acetaminophen	low	2	0
aztreonam	low	1	0
berberine	low	1	0
ciprofloxacin	low	2	0
enoxacin	low	1	0
fluconazole	medium	3	1
gentamicin	medium	29	4
guanidine	low	1	0
ibuprofen	low	1	0
indomethacin	low	4	0
2-propanol	medium	1	1
milrinone	low	1	0
apnea	low	1	0
nifedipine	low	1	0
nitroglycerin	low	1	0
ofloxacin	low	2	0
oxybutynin	low	1	0
propranolol	low	1	0
thyroxine	low	1	0
penicillin g	medium	5	1
chloramphenicol	low	1	0
sucrose	low	1	0
carbostyril	low	1	0
methylene blue	low	2	0
methionine	low	1	0
oxacillin	low	1	0
ampicillin	medium	18	1
taurocholic acid	low	1	0
n-vinyl-2-pyrrolidinone	low	1	0
oxazoles	medium	2	2
thiazoles	medium	1	1
aminophylline	low	1	0
betamethasone	low	3	0
chenodeoxycholic acid	low	1	0
malondialdehyde	low	1	0
erythromycin	low	8	0
monolaurin	low	1	0
s,n,n'-tripropylthiocarbamate	low	1	0
floxacillin	low	3	0
manganese	low	1	0
magnesium sulfate	low	1	0
zinc sulfate	medium	3	3
aluminum sulfate	low	1	0
cefazolin	low	3	0
amoxicillin	low	5	0
tobramycin	low	1	0
dobutamine	low	1	0
ticarcillin	low	1	0
amikacin	low	6	0
nitazoxanide	medium	1	1
piperacillin	low	1	0
simendan	low	1	0
cephalosporin c	medium	15	1
flomoxef	low	5	0
oxazolidin-2-one	low	1	0
nsc-172755	low	1	0
fibrinogen	low	1	0
imipenem, anhydrous	low	1	0
sulbactam	low	1	0
carbapenems	low	6	0
beta-lactams	low	2	0
levofloxacin	low	1	0
colistimethate sodium	low	1	0
trimethoprim, sulfamethoxazole drug combination	low	1	0
povidone-iodine	medium	1	1
raffinose	low	1	0
netilmicin	low	1	0
linezolid	low	4	0
sultamicillin	low	1	0
arachidonic acid	low	1	0
retinol	low	1	0
clindamycin	low	3	0
sodium bicarbonate	low	1	0
methimazole	low	1	0
krn 7000	low	1	0
nitrogen dioxide	low	1	0
bilirubin	medium	5	1
amphotericin b	medium	2	1
clavulanic acid	low	1	0
morphine	low	5	0
cysteine	low	1	0
cefotaxime	medium	5	2
selenium	low	1	0
amoxicillin-potassium clavulanate combination	medium	1	1
sincalide	low	1	0
ppi-0903	medium	2	1
oxadiazoles	medium	2	2
pituitrin	medium	2	1
clove	low	1	0
phosphatidylcholines	low	1	0
ro13-9904	medium	3	1
cardiovascular agents	low	1	0
glycolipids	low	1	0
interleukin-8	low	9	0
colistin	low	9	0
natriuretic peptide, brain	low	1	0
ascorbic acid	low	2	0
minocycline	medium	1	1
warfarin	low	1	0
epidermal growth factor	low	1	0
hyaluronoglucosaminidase	low	1	0
adrenomedullin	low	2	0
lactoferrin	medium	7	1
exudates	low	1	0
neopterin	low	1	0
rifampin	medium	1	1
lipoteichoic acid	low	1	0
tauromuricholate	low	1	0

Protein Targets (956)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
hypoxia-inducible factor 1 alpha subunit	7	0	0	7
RAR-related orphan receptor gamma	19	0	0	19
GLI family zinc finger 3	21	0	0	21
AR protein	21	0	0	21
aldehyde dehydrogenase 1 family, member A1	15	0	0	15
retinoic acid nuclear receptor alpha variant 1	21	0	0	21
retinoid X nuclear receptor alpha	19	0	0	19
estrogen nuclear receptor alpha	38	0	0	38
peroxisome proliferator-activated receptor delta	16	0	0	16
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	11	0	0	11
activating transcription factor 6	10	0	0	10
v-jun sarcoma virus 17 oncogene homolog (avian)	9	0	0	9
Histone H2A.x	6	0	0	6
thyroid hormone receptor beta isoform a	9	0	0	9
heat shock protein beta-1	10	0	0	10
nuclear factor erythroid 2-related factor 2 isoform 1	20	0	0	20
lamin isoform A-delta10	26	0	0	26
Voltage-dependent calcium channel gamma-2 subunit	8	0	0	8
Glutamate receptor 2	8	0	0	8
ATAD5 protein, partial	6	0	0	6
GLS protein	9	0	0	9
Microtubule-associated protein tau	12	0	0	12
Smad3	4	0	0	4
thyroid stimulating hormone receptor	10	0	0	10
nuclear receptor subfamily 1, group I, member 3	12	0	0	12
progesterone receptor	12	0	0	12
EWS/FLI fusion protein	15	0	0	15
estrogen-related nuclear receptor alpha	25	0	0	25
peroxisome proliferator activated receptor gamma	17	0	0	17
aryl hydrocarbon receptor	16	0	0	16
chromobox protein homolog 1	11	0	0	11
thyroid hormone receptor beta isoform 2	19	0	0	19
peripheral myelin protein 22	10	0	0	10
cytochrome P450 3A4 isoform 1	10	0	0	10
Gamma-aminobutyric acid receptor subunit pi	10	3	1	14
ATP-binding cassette sub-family C member 3	0	26	0	26
Multidrug resistance-associated protein 4	0	27	0	28
Solute carrier family 22 member 6	0	7	0	7
Carbonic anhydrase 12	0	3	0	3
UDP-glucuronosyltransferase 1A9	0	0	0	1
Bile salt export pump	0	11	0	12
Bile salt export pump	0	36	0	37
Cytochrome P450 2B1	0	0	0	1
Cytochrome P450 1A1	0	0	0	1
Carbonic anhydrase 1	0	5	0	5
Carbonic anhydrase 2	0	6	1	7
Myoglobin	0	1	0	1
Cytochrome P450 1A1	0	1	1	3
Cytochrome P450 1A2	0	7	0	9
Prostaglandin G/H synthase 1	0	5	0	6
Carbonic anhydrase 3	0	3	0	3
Cytochrome P450 3A4	0	12	1	14
Cytochrome P450 2D6	0	7	0	8
Cytochrome P450 2C9	0	14	0	15
Polyunsaturated fatty acid lipoxygenase ALOX15	0	4	0	4
Gamma-aminobutyric acid receptor subunit beta-1	10	3	1	14
Sulfotransferase 1A1	0	0	0	1
Gamma-aminobutyric acid receptor subunit delta	10	3	1	14
Gamma-aminobutyric acid receptor subunit gamma-2	10	3	1	14
UDP-glucuronosyltransferase 1-6	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	10	3	1	14
Gamma-aminobutyric acid receptor subunit alpha-3	10	3	1	14
Arachidonate 5-lipoxygenase-activating protein	0	1	0	1
UDP-glucuronosyltransferase 1A1	0	1	0	2
Carbonic anhydrase 4	0	4	0	4
Prostaglandin G/H synthase 1	0	5	0	5
Carbonic anhydrase 6	0	3	0	3
Gamma-aminobutyric acid receptor subunit gamma-1	10	3	1	14
Gamma-aminobutyric acid receptor subunit alpha-2	10	3	1	14
Gamma-aminobutyric acid receptor subunit alpha-4	10	3	1	14
Gamma-aminobutyric acid receptor subunit gamma-3	10	3	1	14
Gamma-aminobutyric acid receptor subunit alpha-6	10	3	1	14
Carbonic anhydrase 5A, mitochondrial	0	4	0	4
Prostaglandin G/H synthase 2	0	3	2	7
Carbonic anhydrase 7	0	3	0	3
Nuclear receptor ROR-gamma	9	0	0	9
Cytochrome P450 2J2	0	7	0	7
Gamma-aminobutyric acid receptor subunit alpha-1	10	3	1	14
Gamma-aminobutyric acid receptor subunit beta-3	10	3	1	14
Gamma-aminobutyric acid receptor subunit beta-2	10	3	1	14
Carbonic anhydrase 9	0	5	1	6
GABA theta subunit	10	3	1	14
Canalicular multispecific organic anion transporter 1	0	25	0	25
Carbonic anhydrase 15	0	2	0	2
Carbonic anhydrase 13	0	1	0	1
Gamma-aminobutyric acid receptor subunit epsilon	10	3	1	14
Carbonic anhydrase 14	0	3	0	3
Carbonic anhydrase 5B, mitochondrial	0	4	0	4
toxin B	0	0	0	1
Free fatty acid receptor 3	0	0	1	1
Free fatty acid receptor 2	0	1	1	2
Tyrosine-protein kinase Lck	0	1	1	2
Tyrosine-protein kinase Fyn	0	1	1	2
Fibrinogen C domain-containing protein 1	0	1	0	1
histone acetyltransferase KAT2A isoform 1	7	0	0	7
Aminoglycoside 3'-phosphotransferase	0	0	0	1
ATP-dependent phosphofructokinase	6	0	0	6
thioredoxin reductase	13	0	0	13
USP1 protein, partial	9	0	0	9
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	11	0	0	11
Chain A, Beta-lactamase	7	0	0	7
Chain A, 2-oxoglutarate Oxygenase	13	0	0	13
Beta-lactamase	0	1	0	5
Beta-lactamase	0	1	0	7
Beta-lactamase	0	0	0	7
Beta-lactamase	0	2	0	8
apical membrane antigen 1, AMA1	5	0	0	5
Beta-lactamase	0	0	0	4
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	6	0	0	6
DNA polymerase eta isoform 1	4	0	0	4
DNA polymerase iota isoform a (long)	10	0	0	10
urokinase-type plasminogen activator precursor	4	0	0	4
plasminogen precursor	4	0	0	4
urokinase plasminogen activator surface receptor precursor	4	0	0	4
DNA polymerase kappa isoform 1	11	0	0	11
Beta-lactamase SHV-1	0	1	0	6
Beta-lactamase SHV-1	0	3	0	10
Beta-lactamase	0	2	0	8
Kappa-type opioid receptor	0	2	0	8
Solute carrier family 15 member 1	0	9	0	9
Solute carrier family 15 member 1	0	2	0	2
B2 metallo-beta-lactamase	0	0	0	5
Solute carrier family 15 member 2	0	5	0	5
Beta-lactamase	0	1	0	6
Beta-lactamase	0	1	0	6
Solute carrier family 15 member 2	0	5	0	5
Beta-lactamase	0	1	0	6
Beta-lactamase	0	0	0	5
Chain A, HADH2 protein	9	0	0	9
Chain B, HADH2 protein	9	0	0	9
Chain A, Cruzipain	9	0	0	9
interleukin 8	8	0	0	8
phosphopantetheinyl transferase	12	0	0	12
glucocorticoid receptor [Homo sapiens]	19	0	0	19
farnesoid X nuclear receptor	14	0	0	14
vitamin D (1,25- dihydroxyvitamin D3) receptor	15	0	0	15
tumor necrosis factor	2	0	0	2
vitamin D3 receptor isoform VDRA	9	0	0	9
Cytochrome P450 2C19	0	6	0	7
Potassium voltage-gated channel subfamily H member 2	0	12	0	13
Aurora kinase B	0	2	0	2
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	3	0	3
Chain A, Mutant Al2 6e7p9g	0	0	1	1
Chain A, ATP-DEPENDENT DNA HELICASE Q1	3	0	0	3
Beta-lactamase	0	2	0	5
acid sphingomyelinase	3	0	0	3
Beta-lactamase	0	2	0	6
Beta-lactamase	0	0	0	7
Metallo-beta-lactamase type 2	0	0	1	7
Metallo-beta-lactamase VIM-11	0	0	0	5
euchromatic histone-lysine N-methyltransferase 2	20	0	0	20
Metallo-beta-lactamase VIM-2	0	0	0	5
Beta-lactamase	0	1	0	8
Metallo-beta-lactamase	0	0	0	6
Beta-lactamase	0	2	0	6
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	7	0	0	7
DNA polymerase beta	3	0	0	3
geminin	19	0	0	19
60 kDa heat shock protein, mitochondrial	0	5	0	5
Beta-lactamase OXA-7	0	0	0	3
Spike glycoprotein	11	0	0	11
10 kDa heat shock protein, mitochondrial	0	5	0	5
Angiopoietin-1 receptor	0	0	1	1
Beta-lactamase	0	2	0	5
Beta-lactamase	0	2	0	5
Beta-lactamase	0	2	0	5
Thiosulfate sulfurtransferase	0	5	0	5
Metallo-beta-lactamase VIM-13	0	0	0	6
Efflux transporter	0	0	0	2
Beta-lactamase	0	0	0	5
Beta-lactamase Toho-1	0	0	0	3
Beta-lactamase	0	0	0	2
Class D beta-lactamase	0	2	0	6
60 kDa chaperonin	0	5	0	5
Metallo-beta-lactamase	0	0	0	4
Beta-lactamase	0	2	0	7
Beta-lactamase	0	0	1	5
10 kDa chaperonin	0	5	0	5
Metallo-b-lactamase	0	0	0	8
Carbapenem-hydrolyzing beta-lactamase KPC	0	3	0	9
Histamine H3 receptor	0	0	0	5
Beta-lactamase class B VIM-2	0	0	1	9
Beta-lactamase VIM-1	0	0	0	6
TDP1 protein	23	0	0	23
arylsulfatase A	7	0	0	7
Bloom syndrome protein isoform 1	6	0	0	6
D(1A) dopamine receptor	5	0	0	5
neuropeptide S receptor isoform A	4	0	0	4
Chain A, ADIPOCYTE LIPID-BINDING PROTEIN	0	0	1	1
Chain A, SERUM ALBUMIN	0	0	1	1
Chain A, SERUM ALBUMIN	0	0	1	1
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	5	0	0	5
15-lipoxygenase, partial	4	0	0	4
thioredoxin glutathione reductase	3	0	0	3
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	4	0	0	4
cellular tumor antigen p53 isoform a	5	0	0	5
ubiquitin carboxyl-terminal hydrolase 2 isoform a	3	0	0	3
nuclear receptor ROR-gamma isoform 1	8	0	0	8
lethal(3)malignant brain tumor-like protein 1 isoform I	2	0	0	2
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	1	0	0	1
caspase-1 isoform alpha precursor	2	0	0	2
Fatty-acid amide hydrolase 1	0	1	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15B	4	0	0	4
Prostaglandin G/H synthase 1	0	2	0	4
Trypsin	0	1	0	2
Coagulation factor VII	0	2	0	2
60 kDa chaperonin	0	2	0	2
Aromatase	0	3	0	3
Tissue factor	0	2	0	2
Fatty acid-binding protein, adipocyte	0	1	1	2
Nuclear receptor subfamily 4 group A member 2	0	0	1	1
Histamine H2 receptor	7	0	0	7
Calmodulin	0	0	0	1
Disintegrin and metalloproteinase domain-containing protein 17	3	0	0	3
Prostaglandin G/H synthase 2	0	4	0	5
Solute carrier organic anion transporter family member 2A1	0	0	0	1
Fatty acid-binding protein 5	0	1	0	1
Fatty acid-binding protein 5	0	0	1	1
Lanosterol 14-alpha demethylase	0	5	1	6
Solute carrier organic anion transporter family member 1B3	0	8	0	12
Cytosolic phospholipase A2 gamma	0	2	0	2
Transient receptor potential cation channel subfamily V member 2	0	1	0	1
Solute carrier organic anion transporter family member 1B1	0	8	0	12
Chain A, Hyaluronidase, phage associated	0	1	0	1
acetylcholinesterase	8	0	0	8
cytochrome P450 family 3 subfamily A polypeptide 4	17	0	0	17
IDH1	7	0	0	7
nuclear factor erythroid 2-related factor 2 isoform 2	5	0	0	5
lethal factor (plasmid)	5	0	0	5
Polyphenol oxidase 2	0	3	0	4
Pancreatic alpha-amylase	0	2	0	2
Albumin	0	2	0	3
Urease	0	1	0	1
Prolyl 4-hydroxylase subunit alpha-1	0	0	0	1
Tyrosinase	0	1	0	1
Alpha-2B adrenergic receptor	0	2	3	6
Hyaluronate lyase	0	1	0	1
Prolyl hydroxylase EGLN2	0	0	0	1
Egl nine homolog 1	0	0	0	1
Prolyl hydroxylase EGLN3	0	0	0	1
Hypoxia-inducible factor 1-alpha inhibitor	0	0	0	1
Solute carrier family 23 member 1	0	1	0	1
Chain A, Putative fructose-1,6-bisphosphate aldolase	9	0	0	9
Fumarate hydratase	5	0	0	5
PPM1D protein	5	0	0	5
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	4	0	0	4
polyprotein	5	0	0	5
cytochrome P450 2D6 isoform 1	5	0	0	5
survival motor neuron protein isoform d	6	0	0	6
Telomerase reverse transcriptase	0	1	0	1
Acetylcholinesterase	0	2	0	2
Lysine-specific histone demethylase 1A	0	1	0	1
Interferon beta	17	0	0	17
Neuraminidase	0	1	0	1
Neuraminidase	0	1	0	1
Cholinesterase	0	4	0	4
Tyrosine-protein phosphatase non-receptor type 1	0	1	0	1
Acetylcholinesterase	0	4	0	4
Aldo-keto reductase family 1 member C3	0	4	0	4
Prolyl endopeptidase	0	1	0	1
Aldo-keto reductase family 1 member C2	0	2	0	2
Cholinesterase	0	1	0	1
Inositol monophosphatase 1	5	0	0	5
Cytochrome P450 1B1	0	4	0	4
pregnane X receptor	5	0	0	5
pregnane X nuclear receptor	17	0	0	17
nuclear receptor subfamily 1, group I, member 2	2	0	0	2
galanin receptor type 3	0	1	0	1
Glucocorticoid receptor	0	2	0	2
Glycine receptor subunit alpha-1	0	2	0	2
Glycine receptor subunit beta	0	2	0	2
Glycine receptor subunit alpha-2	0	2	0	2
Glycine receptor subunit alpha-3	0	2	0	2
ORF73	0	0	1	1
Caspase-7	1	0	0	1
Chain A, serum paraoxonase	0	1	0	1
Neutrophil cytosol factor 1	0	1	0	1
Carbonic anhydrase 13	0	2	0	2
Poly [ADP-ribose] polymerase tankyrase-2	0	1	0	1
Chain A, JmjC domain-containing histone demethylation protein 3A	7	0	0	7
Luciferase	11	0	0	11
cytochrome P450 2D6	13	0	0	13
Solute carrier family 22 member 6	0	4	0	4
Solute carrier family 22 member 8	0	5	0	5
Solute carrier family 22 member 11	0	2	0	2
Solute carrier family 22 member 8	0	4	0	5
Beta-lactamase	0	2	0	5
Beta-lactamase	0	3	0	5
Metallo-beta-lactamase VIM-19	0	0	0	5
Beta-lactamase	0	2	0	5
Albumin	0	2	10	12
Beta-lactamase	0	0	0	2
Beta-lactamase	0	2	0	5
Metallo-beta-lactamase VIM-2	0	0	0	5
Solute carrier family 22 member 7	0	1	0	2
BlaVIM-1	0	0	0	5
Beta-lactamase	0	0	0	2
Beta-lactamase	0	1	0	5
Solute carrier family 22 member 7	0	1	0	1
SMAD family member 2	7	0	0	7
SMAD family member 3	7	0	0	7
caspase 7, apoptosis-related cysteine protease	4	0	0	4
caspase-3	4	0	0	4
Caspase-7	2	0	0	2
caspase-3	2	0	0	2
Cellular tumor antigen p53	17	0	0	17
Alpha-2A adrenergic receptor	0	2	4	7
Vitamin D3 receptor	0	1	1	2
Alpha-2C adrenergic receptor	0	1	3	5
Retinoic acid receptor RXR-alpha	0	0	1	1
Guanine nucleotide-binding protein G	4	0	0	4
Ileal sodium/bile acid cotransporter	0	2	0	3
TAR DNA-binding protein 43	7	0	0	7
Bile acid receptor	0	0	1	1
G-protein coupled bile acid receptor 1	0	0	2	2
Bile acid receptor	0	1	1	2
G	14	0	0	14
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	7	0	0	7
streptokinase A precursor	0	0	8	8
Dihydroxyacetone phosphate acyltransferase	0	0	0	1
HLA class I histocompatibility antigen, B alpha chain	14	0	0	14
30S ribosomal protein S6	0	5	1	6
30S ribosomal protein S7	0	5	1	6
50S ribosomal protein L15	0	5	1	6
50S ribosomal protein L10	0	5	1	6
50S ribosomal protein L11	0	5	1	6
50S ribosomal protein L7/L12	0	5	1	6
50S ribosomal protein L19	0	5	1	6
50S ribosomal protein L1	0	5	1	6
50S ribosomal protein L20	0	5	1	6
50S ribosomal protein L27	0	5	1	6
50S ribosomal protein L28	0	5	1	6
50S ribosomal protein L29	0	5	1	6
50S ribosomal protein L31	0	5	1	6
50S ribosomal protein L31 type B	0	5	1	6
50S ribosomal protein L32	0	5	1	6
50S ribosomal protein L33	0	5	1	6
50S ribosomal protein L34	0	5	1	6
50S ribosomal protein L35	0	5	1	6
50S ribosomal protein L36	0	5	1	6
30S ribosomal protein S10	0	5	1	6
30S ribosomal protein S11	0	5	1	6
30S ribosomal protein S12	0	5	1	6
30S ribosomal protein S13	0	5	1	6
30S ribosomal protein S16	0	5	1	6
30S ribosomal protein S18	0	5	1	6
30S ribosomal protein S19	0	5	1	6
30S ribosomal protein S20	0	5	1	6
30S ribosomal protein S2	0	5	1	6
30S ribosomal protein S3	0	5	1	6
30S ribosomal protein S4	0	5	1	6
30S ribosomal protein S5	0	5	1	6
30S ribosomal protein S8	0	5	1	6
30S ribosomal protein S9	0	5	1	6
50S ribosomal protein L13	0	5	1	6
50S ribosomal protein L14	0	5	1	6
50S ribosomal protein L16	0	5	1	6
50S ribosomal protein L23	0	5	1	6
30S ribosomal protein S15	0	5	1	6
50S ribosomal protein L17	0	5	1	6
50S ribosomal protein L21	0	5	1	6
50S ribosomal protein L30	0	5	1	6
50S ribosomal protein L6	0	5	1	6
30S ribosomal protein S14	0	5	1	6
30S ribosomal protein S17	0	5	1	6
30S ribosomal protein S1	0	5	1	6
50S ribosomal protein L18	0	5	1	6
50S ribosomal protein L2	0	5	1	6
50S ribosomal protein L3	0	5	1	6
50S ribosomal protein L24	0	5	1	6
50S ribosomal protein L4	0	5	1	6
50S ribosomal protein L22	0	5	1	6
50S ribosomal protein L5	0	5	1	6
30S ribosomal protein S21	0	5	1	6
50S ribosomal protein L25	0	5	1	6
50S ribosomal protein L36 2	0	5	1	6
Inositol hexakisphosphate kinase 1	14	0	0	14
Methionine--tRNA ligase, mitochondrial	0	0	1	1
cytochrome P450 2C9, partial	14	0	0	14
Chain A, BCL-2-RELATED PROTEIN A1	0	0	2	2
PAX8	0	0	0	1
glp-1 receptor, partial	5	0	0	5
PINK1	1	0	0	1
estrogen receptor 2 (ER beta)	11	0	0	11
67.9K protein	4	0	0	4
glucocerebrosidase	2	0	0	2
Parkin	3	0	0	3
heat shock protein 90	0	0	1	1
calcineurin A1, putative	0	0	1	1
thyroid stimulating hormone receptor	8	0	0	8
hepatocyte nuclear factor 4-alpha isoform 2	0	1	0	1
cytochrome P450 2C19 precursor	3	0	0	3
cytochrome P450 2C9 precursor	5	0	0	5
perilipin-5	0	2	0	2
perilipin-1	0	2	0	2
potassium voltage-gated channel subfamily H member 2 isoform d	4	0	0	4
transcriptional regulator ERG isoform 3	3	0	0	3
huntingtin isoform 2	4	0	0	4
importin subunit beta-1 isoform 1	2	0	0	2
mitogen-activated protein kinase 1	5	0	0	5
ubiquitin-conjugating enzyme E2 N	0	1	0	1
nuclear factor NF-kappa-B p105 subunit isoform 1	1	0	0	1
flap endonuclease 1	4	0	0	4
protein AF-9 isoform a	0	0	0	2
snurportin-1	2	0	0	2
melanocortin receptor 4	0	1	0	1
CAAX prenyl protease	0	0	0	2
bcl-2-related protein A1	0	1	0	1
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform a	0	2	0	2
glycogen synthase kinase-3 alpha	0	0	0	1
hexokinase HKDC1	0	1	0	1
DNA repair protein RAD52 homolog isoform a	0	0	0	2
bcl-2-like protein 11 isoform 1	0	0	2	2
Synaptojanin-2	0	1	0	1
Solute carrier family 22 member 2	0	1	0	1
Solute carrier family 22 member 1	0	4	0	4
Synaptojanin-1	0	1	0	1
Solute carrier family 22 member 3	0	3	0	3
Glutathione reductase, mitochondrial	0	4	0	6
Integrin beta-3	3	0	0	3
72 kDa type IV collagenase	0	1	0	1
Integrin alpha-IIb	3	0	0	3
Matrix metalloproteinase-9	0	2	0	2
Trypanothione reductase	0	1	0	1
Alpha-synuclein	2	2	0	4
Peroxisomal N(1)-acetyl-spermine/spermidine oxidase	0	1	0	1
Multidrug and toxin extrusion protein 2	0	1	0	1
Rap guanine nucleotide exchange factor 4	2	0	0	2
Multidrug and toxin extrusion protein 1	0	4	0	4
ATPase family AAA domain-containing protein 5	6	0	0	6
Ataxin-2	8	0	0	8
Spermine oxidase	0	1	0	1
DNA gyrase subunit B	0	1	0	1
DNA gyrase subunit A	0	1	0	1
DNA gyrase subunit B	0	1	0	2
DNA gyrase subunit A	0	4	0	7
DNA gyrase subunit B	0	4	0	7
DNA topoisomerase 4 subunit A	0	1	0	1
DNA topoisomerase 4 subunit B	0	1	0	2
DNA topoisomerase 4 subunit A	0	1	0	2
DNA topoisomerase 2-alpha	0	1	0	4
DNA gyrase subunit A	0	1	0	2
Multidrug resistance protein MdtK	0	0	1	1
DNA gyrase subunit B	0	4	0	5
DNA gyrase subunit A	0	5	0	6
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	1	0	2
DNA topoisomerase 4 subunit A	0	1	0	1
DNA topoisomerase 4 subunit B	0	1	0	1
Integrase	0	1	0	1
Beta-lactamase	0	2	0	2
Beta-lactamase	0	2	0	3
Beta-lactamase	0	3	0	3
Beta-lactamase	0	2	0	5
Neutrophil elastase	0	1	0	1
Beta-lactamase OXA-1	0	2	0	2
Cytochrome P450 2B6	0	1	1	2
Beta-lactamase TEM	0	5	0	9
Beta-lactamase	0	1	0	1
Beta-lactamase	0	1	0	1
Beta-lactamase	0	1	0	1
Protein-arginine deiminase type-4	0	4	0	4
dopamine D1 receptor	2	0	0	2
GALC protein	1	0	0	1
mu-type opioid receptor isoform MOR-1	0	0	1	1
5-hydroxytryptamine receptor 2A	0	0	1	1
Epidermal growth factor receptor	0	3	0	3
Beta-2 adrenergic receptor	0	4	1	5
Aldo-keto reductase family 1 member B1	0	4	0	4
Beta-1 adrenergic receptor	0	4	1	5
POU domain, class 2, transcription factor 1	0	0	0	1
Sodium-dependent noradrenaline transporter	0	4	1	5
Alpha-1D adrenergic receptor	0	2	1	4
Sodium-dependent serotonin transporter	0	4	0	4
D(3) dopamine receptor	0	4	0	4
Sodium-dependent dopamine transporter	0	4	0	4
Sigma non-opioid intracellular receptor 1	0	7	0	7
V-type proton ATPase subunit B, brain isoform	0	1	0	1
Glutamate receptor ionotropic, NMDA 1	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	1	0	1
Glutamate receptor ionotropic, NMDA 2B	0	1	0	1
Glutamate receptor ionotropic, NMDA 2C	0	1	0	1
RISC-loading complex subunit TARBP2	0	0	1	1
Glutamate receptor ionotropic, NMDA 2D	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	1	0	1
Glutamate receptor ionotropic, NMDA 3A	0	1	0	1
Motilin receptor	0	0	1	1
low molecular weight phosphotyrosine protein phosphatase isoform c	0	1	0	1
serine/threonine-protein kinase PLK1	3	0	0	3
Motilin receptor	0	1	1	2
Rap guanine nucleotide exchange factor 3	3	0	0	3
ATP-dependent translocase ABCB1	0	4	0	4
ATP-dependent translocase ABCB1	0	8	0	9
Chitinase B	0	1	0	1
ATP-dependent translocase ABCB1	0	4	0	4
Low molecular weight phosphotyrosine protein phosphatase	0	1	0	1
unnamed protein product	0	1	0	1
heat shock protein HSP 90-alpha isoform 2	0	0	0	1
Histone deacetylase 3	0	1	0	1
Chymotrypsinogen A	0	1	0	1
Steroid 17-alpha-hydroxylase/17,20 lyase	0	1	0	1
Heme oxygenase 1	0	1	0	1
Lanosterol 14-alpha demethylase	0	1	1	2
Cytochrome P450 11B1, mitochondrial	0	1	0	1
Cytochrome P450 11B2, mitochondrial	0	1	0	1
Heme oxygenase 2	0	1	0	1
Malate dehydrogenase, cytoplasmic	0	1	0	1
Histone deacetylase 4	0	1	0	1
Cytochrome P450 144	0	0	1	1
Steroid C26-monooxygenase	0	0	1	1
Steroid C26-monooxygenase	0	0	1	1
Mycocyclosin synthase	0	0	1	1
Lanosterol 14-alpha demethylase	0	0	1	1
Lanosterol 14-alpha demethylase	0	0	1	1
Histone deacetylase 1	0	1	0	1
Sterol 14-alpha demethylase	0	0	1	1
Sterol 14-alpha demethylase	0	1	1	2
Histone deacetylase 7	0	1	0	1
Histone deacetylase 2	0	1	0	1
Polyamine deacetylase HDAC10	0	1	0	1
Histone deacetylase 11	0	1	0	1
14-alpha sterol demethylase	0	0	1	1
Histone deacetylase 8	0	1	0	1
Histone deacetylase 6	0	1	0	1
Histone deacetylase 9	0	1	0	1
Histone deacetylase 5	0	1	0	1
heat shock protein 90, putative	0	0	0	1
likely tRNA 2'-phosphotransferase	0	1	0	1
UDP-N-acetylglucosamine 1-carboxyvinyltransferase	0	1	0	1
UDP-N-acetylglucosamine 1-carboxyvinyltransferase	0	1	0	1
Solute carrier family 22 member 1	0	2	0	3
Solute carrier family 22 member 2	0	2	0	3
NFKB1 protein, partial	3	0	0	3
nonstructural protein 1	2	0	0	2
muscleblind-like protein 1 isoform 1	4	0	0	4
Acid-sensing ion channel 3	0	1	0	1
Solute carrier organic anion transporter family member 1A4	0	4	0	6
Prostaglandin G/H synthase 2	0	2	0	3
Dihydrofolate reductase	0	1	0	1
Fatty acid-binding protein, liver	0	1	0	1
Albumin	0	0	2	2
Fatty acid-binding protein, intestinal	0	1	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	2	0	4
UDP-glucuronosyltransferase 2B7	0	0	0	1
Prostaglandin G/H synthase 1	0	2	0	2
Adenosine receptor A1	0	2	0	2
Caspase-1	0	2	0	3
Adenosine receptor A2a	0	3	0	3
Substance-P receptor	0	2	0	2
Prostaglandin G/H synthase 2	0	2	0	3
UDP-glucuronosyltransferase 1A3	0	0	0	2
Caspase-3	0	1	0	1
Solute carrier organic anion transporter family member 1A1	0	3	0	4
Caspase-4	0	1	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	1	0	1
Caspase-5	0	1	0	1
Caspase-9	0	1	0	1
Acid-sensing ion channel 1	0	1	0	1
Mu-type opioid receptor	0	3	0	3
Fatty-acid amide hydrolase 1	0	3	0	3
Prostaglandin G/H synthase 2	0	2	0	3
Prostaglandin G/H synthase 1	0	2	0	3
Solute carrier family 22 member 20	0	2	0	2
Solute carrier family 22 member 6	0	2	0	2
Dehydrogenase/reductase SDR family member 9	0	1	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase type 2	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	3
Beta-lactamase	0	0	0	3
Beta-lactamase	0	0	0	1
Beta-lactamase IMP-1	0	0	0	3
Beta-lactamase	0	0	0	3
Chain A, membrane-associated prostaglandin E synthase-2	0	1	0	1
bromodomain adjacent to zinc finger domain 2B	4	0	0	4
peripheral myelin protein 22 isoform 1	4	0	0	4
ras-related protein Rab-9A	3	0	0	3
serine/threonine-protein kinase mTOR isoform 1	2	0	0	2
M-phase phosphoprotein 8	3	0	0	3
Prostaglandin-H2 D-isomerase	0	1	0	1
Prostaglandin E synthase	0	1	0	1
3',5'-cyclic-AMP phosphodiesterase	0	2	0	2
Solute carrier organic anion transporter family member 2B1	0	4	0	5
Cytochrome c oxidase subunit 2	0	1	0	1
Phospholipase A2, major isoenzyme	0	1	0	1
Procathepsin L	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-4	0	1	0	1
Interleukin-8	0	1	0	1
Androgen receptor	0	0	1	1
Neuronal acetylcholine receptor subunit beta-2	0	1	0	1
Aldo-keto reductase family 1 member B1	0	2	0	2
Aldo-keto reductase family 1 member B1	0	1	0	1
Aldo-keto reductase family 1 member C4	0	1	0	1
Sodium-dependent dopamine transporter	0	2	0	2
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Thromboxane-A synthase	0	2	0	2
Serum paraoxonase/arylesterase 1	0	1	0	1
Indoleamine 2,3-dioxygenase 1	0	2	0	2
Nitric oxide synthase, inducible	0	1	0	1
Prostaglandin E2 receptor EP3 subtype	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Prostaglandin E2 receptor EP4 subtype	0	1	0	1
Multidrug resistance-associated protein 1	0	1	0	1
Bifunctional epoxide hydrolase 2	0	1	0	1
Prostaglandin E2 receptor EP1 subtype	0	1	0	1
Peroxisome proliferator-activated receptor gamma	0	0	3	3
Sodium- and chloride-dependent betaine transporter	0	1	0	1
C-X-C chemokine receptor type 3	0	1	0	1
Prostaglandin D2 receptor	0	2	0	2
Solute carrier organic anion transporter family member 1A3	0	2	0	4
Lactoylglutathione lyase	0	1	0	1
Aldo-keto reductase family 1 member C1	0	1	0	1
Uracil nucleotide/cysteinyl leukotriene receptor	0	1	0	1
Sigma intracellular receptor 2	0	1	0	1
Prostaglandin E2 receptor EP2 subtype	0	1	0	1
Rho-associated protein kinase 2	0	1	0	1
Nicotinate phosphoribosyltransferase	0	1	0	1
Dehydrogenase/reductase SDR family member 9	0	1	0	1
P2Y purinoceptor 12	0	1	0	1
Prostaglandin D2 receptor 2	0	1	1	2
Replicase polyprotein 1ab	0	1	0	1
CAAX prenyl protease 2 isoform 2	0	0	0	1
Tubulin beta-4A chain	0	1	0	1
Tubulin beta chain	0	1	0	1
Tubulin alpha-3C chain	0	1	0	1
Tubulin alpha-1B chain	0	1	0	1
Tubulin alpha-4A chain	0	1	0	1
Tubulin beta-4B chain	0	1	0	1
DNA primase	0	1	0	1
Tubulin beta-3 chain	0	1	0	1
Tubulin beta-2A chain	0	1	0	1
Tubulin beta-8 chain	0	1	0	1
Tubulin alpha-3E chain	0	1	0	1
Tubulin alpha-1A chain	0	1	0	1
Tubulin alpha-1C chain	0	1	0	1
Tubulin beta-6 chain	0	1	0	1
Tubulin beta-2B chain	0	1	0	1
Tubulin beta-1 chain	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1F	0	4	0	4
Estrogen receptor	0	0	1	1
Amine oxidase [flavin-containing] B	0	1	0	1
Amine oxidase [flavin-containing] A	0	3	0	3
Amine oxidase [flavin-containing] B	0	1	0	1
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	4	0	4
Voltage-dependent L-type calcium channel subunit alpha-1S	0	4	0	4
Voltage-dependent L-type calcium channel subunit alpha-1C	0	5	0	6
Dual specificity tyrosine-phosphorylation-regulated kinase 1A	0	1	0	1
Estrogen receptor beta	0	0	1	1
Renin	0	1	0	1
ClpP	1	0	0	1
regulator of G-protein signaling 4	4	0	0	4
muscarinic acetylcholine receptor M1	4	0	0	4
Cytochrome P450 1A2	0	1	0	1
Myeloperoxidase	0	1	0	1
Cytochrome P450 2C11	0	1	0	1
Ribosyldihydronicotinamide dehydrogenase [quinone]	0	2	0	2
Metabotropic glutamate receptor 1	0	1	0	1
Acetylcholinesterase	0	1	0	1
Mu-type opioid receptor	0	5	2	10
Nociceptin receptor	0	1	0	1
Alpha-1A adrenergic receptor	0	6	1	7
Melatonin receptor type 1A	0	2	1	3
Melatonin receptor type 1C	0	0	1	1
Melatonin receptor type 1A	0	1	1	2
Melatonin receptor type 1B	0	2	1	3
Melatonin receptor type 1C	0	1	1	2
Melatonin receptor type 1B	0	1	1	2
Nuclear factor erythroid 2-related factor 2	0	0	0	1
Palmitoleoyl-protein carboxylesterase NOTUM	0	1	0	1
Carboxylic ester hydrolase	0	1	0	1
Histamine H3 receptor	0	1	0	1
Dopamine beta-hydroxylase	0	2	0	2
Lactoperoxidase	0	1	0	1
Chain A, Methionyl-tRNA synthetase	0	0	1	1
Chain A, Methionyl-tRNA synthetase	0	0	1	1
Chain A, Aminopeptidase	0	1	0	1
Chain A, Methionine aminopeptidase	0	1	0	1
S-ribosylhomocysteine lyase	0	1	0	1
Adenylate cyclase type 5	0	0	0	1
S-adenosylmethionine synthase isoform type-1	0	0	0	1
S-adenosylmethionine synthase isoform type-2	0	0	0	1
Fatty acid synthase	0	1	0	1
Large neutral amino acids transporter small subunit 1	0	1	0	1
Chain E, Fibrin beta chain	0	1	0	1
Chain A, Ferritin light chain	3	0	0	3
T cell receptor, partial	1	0	0	1
luteinizing hormone receptor	1	0	0	1
integrase, partial	0	1	0	1
chaperonin-containing TCP-1 beta subunit homolog	1	0	0	1
lens epithelium-derived growth factor p75	0	1	0	1
Caspase 6, apoptosis-related cysteine peptidase	0	0	0	1
TSHR protein	1	0	0	1
Apoptotic peptidase activating factor 1	0	1	0	1
hypothetical protein, conserved	3	0	0	3
isocitrate dehydrogenase 1, partial	1	0	0	1
luciferase	1	0	0	1
serine-protein kinase ATM isoform a	1	0	0	1
neutrophil cytosol factor 1	0	1	0	1
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	4	0	0	4
caspase-9 isoform alpha precursor	0	1	0	1
histone deacetylase 9 isoform 3	2	0	0	2
pyruvate kinase PKM isoform a	2	0	0	2
caspase-3 isoform a preproprotein	0	1	0	1
histone-lysine N-methyltransferase 2A isoform 2 precursor	2	0	0	2
Vpr	3	0	0	3
replicative DNA helicase	0	0	0	1
recombinase A	0	0	1	1
POsterior Segregation	0	0	1	1
Glutathione reductase	0	1	0	1
Glycoprotein hormones alpha chain	1	0	0	1
Amyloid-beta precursor protein	0	3	0	3
Dihydrolipoyl dehydrogenase, mitochondrial	0	1	0	2
Microtubule-associated protein tau	0	1	1	2
Alpha-1B adrenergic receptor	0	5	1	6
Alpha-1D adrenergic receptor	0	3	1	4
Cruzipain	0	1	0	1
Thioredoxin reductase 1, cytoplasmic	0	1	0	2
Dihydrolipoyl dehydrogenase	0	1	0	2
Zinc finger protein mex-5	0	0	1	1
phosphoglycerate kinase	1	0	0	1
Phosphodiesterase	0	1	0	1
cGMP-dependent 3',5'-cyclic phosphodiesterase	0	2	0	2
Aurora kinase A	0	1	0	1
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A	0	2	0	2
cGMP-specific 3',5'-cyclic phosphodiesterase	0	2	0	2
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	2	0	2
Dual specificity protein kinase TTK	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	2	0	2
cAMP-specific 3',5'-cyclic phosphodiesterase 4C	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	2	0	2
cGMP-inhibited 3',5'-cyclic phosphodiesterase B	0	2	0	2
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	0	2	0	2
cGMP-inhibited 3',5'-cyclic phosphodiesterase A	0	3	0	3
cGMP-specific 3',5'-cyclic phosphodiesterase	0	1	0	1
Inner centromere protein	0	1	0	1
Phosphodiesterase	0	1	0	1
Stromelysin-1	0	1	0	1
Matrilysin	0	1	0	1
Multidrug transporter MdfA	0	1	0	1
Protein mono-ADP-ribosyltransferase PARP15	0	2	0	2
Opioid receptor, delta 1b	0	1	0	1
Opioid receptor homologue	0	1	0	1
Acyl-CoA desaturase 1	0	1	0	1
Muscarinic acetylcholine receptor M1	0	2	0	2
Muscarinic acetylcholine receptor M3	0	2	0	2
Muscarinic acetylcholine receptor M4	0	1	0	1
Muscarinic acetylcholine receptor M5	0	1	0	1
Muscarinic acetylcholine receptor M2	0	2	0	2
Translocator protein	0	0	1	1
Histidine decarboxylase	0	0	1	1
Proteinase-activated receptor 1	0	1	1	2
Sodium-dependent serotonin transporter	0	2	0	2
Delta-type opioid receptor	0	1	0	2
Delta-type opioid receptor	0	2	1	4
Kappa-type opioid receptor	0	2	1	4
Kappa-type opioid receptor	0	2	1	4
Mu-type opioid receptor	0	3	2	6
Delta-type opioid receptor	0	3	3	7
Kappa-type opioid receptor	0	3	2	6
Mu-type opioid receptor	0	2	1	5
Nociceptin receptor	0	1	0	1
5-hydroxytryptamine receptor 7	0	2	0	2
Mu-type opioid receptor	0	1	0	1
Beta-2 adrenergic receptor	0	2	1	5
Mas-related G-protein coupled receptor member X2	0	0	1	1
Mu-type opioid receptor	0	1	0	1
Atrial natriuretic peptide receptor 1	0	1	0	1
Tyrosyl-DNA phosphodiesterase 1	0	1	0	1
Chain A, NAD-dependent deacetylase	0	1	0	1
Poly [ADP-ribose] polymerase 2	0	1	0	1
NAD-dependent histone deacetylase SIR2	0	1	0	1
Poly [ADP-ribose] polymerase 1	0	1	0	1
Cytochrome P450 3A5	0	1	0	1
NAD-dependent protein deacetylase HST2	0	1	0	1
NAD(+) hydrolase SARM1	0	1	0	1
NAD-dependent protein deacetylase sirtuin-2	0	1	0	1
NAD-dependent protein deacetylase sirtuin-6	0	1	0	1
NAD-dependent protein deacetylase sirtuin-1	0	1	0	1
NAD-dependent protein deacetylase sirtuin-3, mitochondrial	0	1	0	1
NAD-dependent protein deacylase sirtuin-5, mitochondrial	0	1	0	1
NAD-dependent protein deacetylase	0	1	0	1
Thrombopoietin	1	0	0	1
beta-2 adrenergic receptor	1	0	0	1
polyunsaturated fatty acid lipoxygenase ALOX12	1	0	0	1
atrial natriuretic peptide receptor 2 precursor	1	0	0	1
eyes absent homolog 2 isoform a	1	0	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	2	0	2
5-hydroxytryptamine receptor 4	0	4	0	4
Potassium channel subfamily K member 2	0	0	1	1
Muscarinic acetylcholine receptor M2	0	3	2	7
Muscarinic acetylcholine receptor M4	0	2	0	3
Muscarinic acetylcholine receptor M5	0	2	0	3
Adenosine receptor A3	0	3	1	4
Muscarinic acetylcholine receptor M1	0	3	1	6
Phospholipase A2, membrane associated	0	0	0	1
5-hydroxytryptamine receptor 2A	0	2	1	3
Muscarinic acetylcholine receptor M3	0	3	1	5
Voltage-dependent L-type calcium channel subunit alpha-1C	0	3	0	3
Potassium voltage-gated channel subfamily A member 5	0	1	0	1
3-oxo-5-alpha-steroid 4-dehydrogenase 1	0	1	0	1
Platelet-activating factor receptor	0	0	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	1	0	1
5-hydroxytryptamine receptor 2C	0	4	1	5
Adenosine receptor A2a	0	2	1	3
Adenosine receptor A1	0	2	0	2
3-oxo-5-alpha-steroid 4-dehydrogenase 2	0	1	0	1
Sodium channel protein type 1 subunit alpha	0	1	0	1
Sodium channel protein type 4 subunit alpha	0	1	0	1
C-C chemokine receptor type 2	0	2	0	2
Sodium channel protein type 7 subunit alpha	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	1	0	1
Potassium voltage-gated channel subfamily A member 1	0	1	0	1
C-terminal-binding protein 1	1	0	0	1
Sodium channel protein type 5 subunit alpha	0	2	0	2
Leukotriene B4 receptor 1	0	0	0	1
Myosin light chain kinase, smooth muscle	0	1	0	1
Sodium channel protein type 9 subunit alpha	0	1	0	1
Transient receptor potential cation channel subfamily A member 1	0	0	1	1
Potassium channel subfamily K member 2	0	1	0	1
Indoleamine 2,3-dioxygenase 2	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1F	0	1	0	1
Leukotriene B4 receptor 2	0	0	0	1
Sodium channel protein type 3 subunit alpha	0	1	0	1
Sodium channel protein type 11 subunit alpha	0	1	0	1
Sodium channel protein type 8 subunit alpha	0	1	0	1
Sodium channel protein type 10 subunit alpha	0	1	0	1
pyruvate kinase	1	0	0	1
NPC intracellular cholesterol transporter 1 precursor	1	0	0	1
Endothelin receptor type B	1	0	0	1
Endothelin-1 receptor	1	0	0	1
Signal transducer and activator of transcription 3	0	1	0	1
Pyruvate-flavodoxin oxidoreductase	0	1	0	1
Anoctamin-1	0	1	0	1
STE24	0	0	0	1
Solute carrier family 22 member 8	0	3	0	4
MecA	0	1	0	1
5-hydroxytryptamine receptor 2B	0	4	1	5
MBT domain-containing protein 1	0	1	0	1
Lethal(3)malignant brain tumor-like protein 4	0	1	0	1
Muscarinic acetylcholine receptor	0	0	1	1
Lethal(3)malignant brain tumor-like protein 3	0	1	0	1
Lethal(3)malignant brain tumor-like protein 1	0	1	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase 1	0	0	0	1
Beta-lactamase OXA-10	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	1	0	4
endonuclease IV	1	0	0	1
vasopressin V1b receptor	1	0	0	1
relaxin receptor 1 isoform 1	1	0	0	1
Tumor necrosis factor	0	1	0	1
Adenosine receptor A2b	0	1	0	1
Chitotriosidase-1	0	2	1	3
Endochitinase B1	0	2	1	3
Nuclear receptor subfamily 1 group I member 2	0	0	3	3
Genome polyprotein	0	0	1	2
Genome polyprotein	0	0	1	1
Genome polyprotein	0	0	1	1
Beta-1 adrenergic receptor	0	1	1	3
5-hydroxytryptamine receptor 1A	0	1	0	1
Beta-2 adrenergic receptor	0	2	0	3
Cytochrome P450 2C8	0	1	0	1
Beta-3 adrenergic receptor	0	2	1	3
D(2) dopamine receptor	0	1	1	2
Beta-1 adrenergic receptor	0	2	1	4
D(3) dopamine receptor	0	1	0	1
5-hydroxytryptamine receptor 1A	0	3	1	5
Alpha-2B adrenergic receptor	0	1	1	2
D(1A) dopamine receptor	0	1	1	2
Alpha-2C adrenergic receptor	0	1	1	2
Alpha-2A adrenergic receptor	0	1	1	2
Endothelin-1 receptor	0	1	1	2
Beta-3 adrenergic receptor	0	2	0	2
5-hydroxytryptamine receptor 1B	0	2	1	3
5-hydroxytryptamine receptor 2A	0	2	1	3
5-hydroxytryptamine receptor 1B	0	2	0	2
Neuromedin-K receptor	0	0	1	1
Type-1 angiotensin II receptor	0	1	1	2
Cholecystokinin receptor type A	0	3	3	6
5-hydroxytryptamine receptor 7	0	1	1	2
Beta-1 adrenergic receptor	0	1	0	1
Alpha-1A adrenergic receptor	0	1	2	4
Alpha-1B adrenergic receptor	0	0	1	2
Vasopressin V1a receptor	0	1	1	2
5-hydroxytryptamine receptor 6	0	2	1	3
Beta-2 adrenergic receptor	0	1	0	1
Sodium/bile acid cotransporter	0	2	0	3
Nuclear receptor subfamily 2 group E member 1	0	0	2	2
PA-I galactophilic lectin	0	0	1	1
Chain A, PLASMA RETINOL-BINDING PROTEIN PRECURSOR	0	0	1	1
Retinol-binding protein 4	0	0	1	1
Beta-lactoglobulin	0	0	1	1
DNA-directed RNA polymerase subunit beta	0	1	0	1
NH(3)-dependent NAD(+) synthetase	0	1	0	1
Arylacetamide deacetylase	0	1	0	2
Solute carrier organic anion transporter family member 1A2	0	1	0	3
Glutathione S-transferase omega-1	0	1	0	1
DNA-directed RNA polymerase subunit beta	0	1	0	1
Cholecystokinin receptor type A	0	1	0	1
Cholecystokinin receptor type A	0	2	0	2
Gastrin/cholecystokinin type B receptor	0	1	1	2
Gastrin/cholecystokinin type B receptor	0	2	2	4
Gastrin/cholecystokinin type B receptor	0	2	0	2
Cholecystokinin receptor type A	0	2	0	2
Solute carrier organic anion transporter family member 1B2	0	0	0	2
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Chain A, MALTOPORIN	0	0	1	1
Chain B, MALTOPORIN	0	0	1	1
Replicase polyprotein 1ab	0	1	0	1
Metallo-beta-lactamase type 2	0	1	0	1
Angiotensin-converting enzyme	0	1	0	1
Sodium/bile acid cotransporter	0	0	0	1
Solute carrier organic anion transporter family member 1A5	0	0	0	2
ATP-binding cassette sub-family C member 3	0	0	0	1
Sodium/bile acid cotransporter	0	1	0	2
Ileal sodium/bile acid cotransporter	0	0	0	1
Ileal sodium/bile acid cotransporter	0	0	0	1
Solute carrier organic anion transporter family member	0	0	0	1
Solute carrier organic anion transporter family member 4A1	0	0	0	1
Multidrug resistance associated protein	0	1	0	2
Solute carrier organic anion transporter family member 1C1	0	1	0	1
Solute carrier organic anion transporter family member 2B1	0	0	0	1
Solute carrier organic anion transporter family member 1A1	0	0	0	1
Bile salt export pump	0	0	0	1
Chain X, Thyroid hormone receptor beta-1	0	0	1	1
Chain X, Thyroid hormone receptor beta-1	0	0	1	1
Transthyretin	0	1	0	2
Thyroid hormone receptor alpha	0	0	1	1
Thyroid hormone receptor beta	0	0	1	1
Proliferating cell nuclear antigen	0	1	0	1
Retinoic acid receptor RXR-alpha	0	0	2	2
Malate dehydrogenase, mitochondrial	0	1	0	1
Solute carrier organic anion transporter family member 4C1	0	1	0	1
Monocarboxylate transporter 8	0	0	0	1
Solute carrier organic anion transporter family member 1C1	0	0	0	1
Protein Rev	0	0	1	1
D-alanyl-D-alanine dipeptidase	0	1	0	1
Transporter	0	1	0	1
Proprotein convertase subtilisin/kexin type 7	0	1	0	1
Vitamin K epoxide reductase complex subunit 1-like protein 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1	0	1	0	1
Protease	0	1	0	1
Vitamin K epoxide reductase complex subunit 1-like protein 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1	0	2	0	2
twin arginine protein translocation system - TatA protein	0	0	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(1)

Research Excerpts

Overview

Treatment

Research

Studies (247)

Protein Targets (956)

Neonatal Sepsis

Synonyms(1)

Research Excerpts

Overview

Treatment

Research

Studies (247)

Drugs Studied (138)

Protein Targets (956)