Candidemia

A form of invasive candidiasis where species of CANDIDA are present in the blood.

Synonym
Candidemia

Excerpt	Reference
"Candidemia is a serious condition associated with high morbidity and mortality and increased healthcare costs in pediatric patients."	( Celebi, S; Hacimustafaoglu, M, 2011)
"Candidemia is a major infectious complication in neonatal patients."	( Barbuti, G; Caggiano, G; Coretti, C; Laforgia, N; Manca, F; Montagna, MT; Montagna, O; Rella, A, 2013)
"Once candidemia is found, ophthalmologic examination and systemic antifungal therapy are needed."	( Furukawa, K; Kazama, I, 2012)
"Candidemia is not confined to hematological patients, intensive care units or abdominal surgery wards, but it is remarkably frequent in the internal medicine setting."	( Del Bono, V; Mikulska, M; Ratto, S; Viscoli, C, 2012)
"Candidemia is a significant cause of morbidity and mortality in hospitalized patients, particularly in Asia."	( Co, VM; Hsueh, PR; Mootsikapun, P; Ong, ML; Rajadhyaksha, V; Talwar, D, 2013)
"Candidemia is associated with high mortality rate especially in critically ill (ICU) patients with septic shock and echinocandins such as anidulafungin are recommended as first-line treatment."	( Baietto, L; Corcione, S; D'Avolio, A; De Rosa, FG; Di Perri, G; Pasero, D; Ranieri, VM, 2013)
"Candidemia is among the most common nosocomial bloodstream infections and is associated with high mortality, increased length of hospital stay, and significant economic burden."	( Clancy, CJ; Eschenauer, GA; Nguyen, MH, 2015)
"Candidemia is an increasing problem in tertiary care hospitals worldwide."	( Casulari, LA; Colombo, AL; Damasceno, CM; Pinhati, HM; Siqueira, RA; Souza, AC, 2016)
"Surveillance of candidemia is essential to monitor trends in species distribution and change in the incidence and antifungal resistance."	( Alp, E; Cevahir, F; Ture, Z; Ulu Kilic, A; Yozgat, N, 2017)
"The incidence of candidemia is increasing in developing countries."	( Agurto, C; Bustamante, B; Diaz, A; Hidalgo, J; Huaroto, L; Illescas, R; Ramirez, R; Rodriguez, L, 2017)
"Candidemia is frequent in critically ill patients, especially in combination with an acute kidney injury (AKI)."	( Graf, BM; Gruber, M; Ittner, KP; Kolbinger, P; Roth, G, 2018)
"The mortality of candidemia is affected by the underlying conditions, causative agents and the initial management."	( Ide, K; Kato, H; Matsuno, K; Nakajima, H; Shimizu, H; Sugiyama, Y; Suido, Y; Yoshimura, Y, 2019)
"Candidemia is a major cause of in-hospital mortality."	( Barnini, S; Bertolino, G; Carmignani, C; Dal Canto, L; Desideri, I; Menichetti, F; Ripoli, A; Rosselli Del Turco, E; Sbrana, F; Sozio, E; Tagliaferri, E; Tascini, C, 2018)
"auris colonization/candidemia are similar to other Candida species."	( Alastruey-Izquierdo, A; Calabuig, E; Frasquet, J; López-Hontangas, JL; Martínez, H; Mollar, J; Moret, AM; Pemán, J; Ramírez, P; Ruiz-Gaitán, A; Salavert-Lletí, M; Tasias, M; Zaragoza, Ó, 2019)
"C parapsilosis candidemia is an emerging issue in our center, possibly attributed to some extent to horizontal transmission of the pathogen, as confirmed by the analysis of isolates similarities."	( Beltramini, S; Codda, G; Del Bono, V; Del Puente, F; Gandolfo, N; Giacobbe, DR; Icardi, G; Marchese, A; Mesini, A; Mikulska, M; Orsi, A; Tassinari, F; Viscoli, C, 2020)
"Candidemia is a major cause of mortality in the intensive care unit (ICU)."	( Argaud, L; Aubrun, F; Bienvenu, AL; Chidiac, C; Fellahi, JL; Friggeri, A; Guerin, C; Guichon, C; Hernu, R; Leboucher, G; Menotti, J; Monard, C; Paulus, S; Piriou, V; Pradat, P; Rimmele, T, 2020)
"Candidemia is the fourth frequent reason of healthcare-related bloodstream infections in critically ill patients."	( Farhadi, T; Hashemian, SM; Velayati, AA, 2020)
"Landscape of candidemia is blurred in Iran, and only two studies from Tehran have extensively explored the epidemiology of candidemia."	( Arastehfar, A; Bakhtiari, M; Boekhout, T; Daneshnia, F; Fang, W; Ilkit, M; Mahmoudi, S; Pakshir, K; Pan, W; Perlin, DS; Yazdanpanah, S; Zand, F; Zomorodian, K, 2021)
"Candidemia is among the most frequent nosocomial bloodstream infections."	( Cornely, FB; Cornely, OA; Koehler, FC; Koehler, P; Mellinghoff, SC; Salmanton-García, J; Seifert, H; Wingen-Heimann, S, 2020)
"Candidemia is an alarming problem in critically ill patients including those admitted in intensive care units (ICUs)."	( Barchiesi, F; Brescini, L; Cerutti, E; Donati, A; Mazzanti, S; Montalti, R; Morroni, G; Munch, C; Orsetti, E; Pocognoli, A, 2021)
"Candidemia is a common opportunistic infection causing substantial morbidity and mortality."	( Barter, DM; Czaja, CA; Davis, SS; Farley, MM; Fischer, J; Gold, JAW; Harrison, LH; Jackson, BR; Johnston, H; Lockhart, SR; Lyman, M; Markus, TM; Mody, RK; Nadle, J; Pattee, B; Phipps, EC; Schaffner, W; Seagle, EE; Tesini, BL; Thomas, S; Vallabhaneni, S; Zhang, AY, 2021)
"Candidemia is one of the most common nosocomial bloodstream infections in the United States, causing significant morbidity and mortality in hospitalized patients, but the breadth of the host response to Candida infections in human patients remains poorly defined."	( Alexander, BD; Ginsburg, GS; Henao, R; Hua, K; Johnson, MD; McClain, MT; Myers, RA; Seidelman, JL; Steinbrink, JM; Tsalik, EL; Woods, CW, 2021)
"Candidemia is the fourth common cause of blood stream infection worldwide leading to increased mortality and morbidity."	( Banu, H; Chakraborty, M; Gupta, MK, 2021)
"Predicting candidemia is essential in critically ill patients who are at high risk and have high mortality rates."	( Akinci, E; Bastug, A; Bodur, H; Calci, E; Kayaaslan, B; Kazancioglu, S; Mumcuoglu, I; Mutlu, NM; Turhan, T, 2022)
"Candidemia is one of the significant causes of mortality amongst critically ill patients in Intensive Care Units (ICUs)."	( Gupta, S; Jain, A; Jangid, Y; Rajni, E; Vohra, R, 2022)
"Candidemia is increasing in frequency and is associated with high mortality."	( Barkema, HW; Biesheuvel, MM; Bourassa-Blanchette, S; Carson, J; Church, D; Dalton, B; Gregson, DB; Kipp, A; Lam, JC; Parkins, MD, 2023)
"Candidemia is a serious complication in pediatric patients with congenital heart defects (CHD) after cardiac surgery."	( Armoni-Domany, K; Barkai, G; Kahan, Y; Mandelberg, A; Ovadia, A; Shatzman-Steuerman, R; Sherman, G; Shpring, A; Tasher, D; Tope, SG, 2023)
"Candidemia is a life-threatening disease common in immunocompromised patients, and is generally caused by the pathogenic fungus Candida albicans."	( Kinoshita, K; Koyama, K; Kurakado, S; Matsumoto, Y; Sasaki, H; Sugita, T; Yoshino, Y, 2023)
"Candidemia is responsible for substantial morbidity and mortality in neonatal intensive care units and represents a challenge due to the complexity of hospitalized neonates, the deficiency in approved and precise diagnostic techniques, and the increasing number of species resistant to antifungal agents."	( Amorim, RJM; da Silva, CM; de Carvalho, AMR; Jucá, MB; Macêdo, DPC; Neves, RP, 2023)
"Candidemia is the fourth most common nosocomial bloodstream infection."	( Jahangir, A; Javed, A; Sahra, S; Thind, SK, 2023)
"Candidemia is a life-threatening invasive fungal infection in immunocompromised patients."	( Abdel-Hamid, RM; Abdelfattah, NE; El-Mahallawy, HA; Wassef, MA, 2023)
"Candidemia is associated with a heavy burden of morbidity and mortality in hospitalized patients."	( Bassetti, M; Brucci, G; Campi, C; Di Biagio, A; Giacobbe, DR; Giacomini, M; Guastavino, S; Limongelli, A; Marchese, A; Marelli, C; Mikulska, M; Mora, S; Peluso, S; Russo, C; Signori, A; Tayefi, M; Vena, A, 2023)

Excerpt	Reference
"The spectrum of candidemia has changed with the emergence of non-albicans Candida species, especially among critically ill patients."	( Chander, J; Gombar, S; Sidhu, SK; Singla, N, 2013)
"The incidence of candidemia has increased over the past two decades, with an increased number of cases in Internal Medicine and a prevalence ranging from 24% to 57%."	( Aldieri, C; Cavallo, R; Corcione, S; De Rosa, FG; Di Perri, G; Filippini, C; Fossati, L; Montrucchio, C; Petrolo, A; Raviolo, S, 2015)
"Although candidemia has been reported globally, little is known about the differences in candidemia episodes between ICU and surgical wards or the correlation between serum biomarkers and mortality from candidemia."	( Cao, J; Jia, X; Li, C; Wu, X; Zhang, L, 2018)
"parapsilosis candidemia has been recently observed as a result of many risk factors."	( Harun, A; Husin, A; Yamin, D, 2020)

Excerpt	Reference
"The mortality of candidemia is affected by the underlying conditions, causative agents and the initial management."	( Ide, K; Kato, H; Matsuno, K; Nakajima, H; Shimizu, H; Sugiyama, Y; Suido, Y; Yoshimura, Y, 2019)

Excerpt	Reference
"Only costs attributable to the treatment of candidemia were estimated by reviewing resource utilization during treatment."	( Chang, HH; Ha, YE; Han, SH; Joo, EJ; Jung, SI; Kim, SW; Park, KH; Peck, KR, 2012)
"Caspofungin successfully treated persistent candidemia in extremely premature infants at 23 and 24 weeks' gestational age."	( Jeon, GW; Sin, JB, 2014)
"It may also prove useful for the treatment of candidemia and invasive mold infections; however, these indications await the results of clinical trials."	( Carver, PL; Pettit, NN, 2015)
"Improved treatment of candidemia may ultimately be achieved by optimizing the use of antifungal agents rather than the development of new drugs."	( Clancy, CJ; Eschenauer, GA; Nguyen, MH, 2015)
"glabrata, following treatment for candidemia."	( Arendrup, MC; Astvad, KM; Dzajic, E; Jensen, RH; Johansen, HK; Kristensen, L; Lemming, LE; Nielsen, L; Olesen, B; Rosenvinge, FS; Søes, LM, 2015)
"Whether echinocandins could be used to treat candidemia of a urinary tract source (CUTS) is unknown."	( Aguado, JM; Almirante, B; Ayats, J; Blanco-Vidal, MJ; Cardozo, C; Carratalà, J; Cuervo, G; Fernández-Ruiz, M; Garcia-Vidal, C; González-Barberá, E; Gudiol, C; Manzur, A; Marco, F; Meije, Y; Montejo, JM; Muñoz, P; Pemán, J; Puig-Asensio, M; Vena, A, 2017)
"Antifungals used for treating candidemia were (no IDC/IDC): azoles (74%/42%); echinocandins (0%/46%); liposomal and lipidic complex amphotericin B (0%/12%)."	( Barnini, S; Bertolino, G; Carmignani, C; Dal Canto, L; Desideri, I; Menichetti, F; Ripoli, A; Rosselli Del Turco, E; Sbrana, F; Sozio, E; Tagliaferri, E; Tascini, C, 2018)
"We introduced the Early Fluconazole Treatment in Candidemia (EFTC) protocol in August 2015 to improve the outcomes of patients with candidemia."	( Heo, ST; Jo, S; Shin, BR; Yoo, JR, 2021)
"RZF was safe and efficacious in the treatment of candidemia and/or IC."	( Bassetti, M; Das, AF; Honore, PM; Horcajada, JP; Ostrosky-Zeichner, L; Pappas, PG; Sandison, T; Skoutelis, A; Soriano, A; Spapen, H; Thompson, GR; Vazquez, JA; Viani, RM, 2021)
"The first line treatment of candidemia and invasive candidiasis are echinocandins including caspofungin, anidulafungin and micafungin."	( Salzer, HJF, 2023)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	0 (0.00)	23.3326
1990's	0 (0.00)	12.5806
2000's	0 (0.00)	18.1394
2010's	356 (73.86)	28.8240
2020's	126 (26.14)	9.53

Drug	Relationship Strength	Studies	Trials
carbon monoxide	low	1	0
lactic acid	low	1	0
fentanyl	low	1	0
flucytosine	low	10	0
hydroxychloroquine	low	1	0
ketoconazole	low	1	0
mesalamine	low	1	0
metronidazole	low	1	0
midazolam	low	1	0
apnea	low	1	0
ofloxacin	low	1	0
pioglitazone	low	1	0
2,3-bis(2-methoxy-4-nitro-5-sulfophenyl)-5-((phenylamino)carbonyl)-2h-tetrazolium hydroxide	low	2	0
prednisone	low	1	0
galactose	low	1	0
leucine	low	1	0
methylprednisolone	low	1	0
fusarium	low	1	0
gentian violet	low	4	0
acetylcysteine	low	1	0
vancomycin	low	4	0
acetylglucosamine	low	1	0
copper sulfate	low	1	0
paclitaxel	low	1	0
dobutamine	low	1	0
itraconazole	low	15	0
cephalosporin c	low	2	0
triazoles	medium	31	3
sr141716	low	1	0
methotrexate	low	1	0
carbapenems	low	3	0
beta-lactams	low	1	0
levofloxacin	low	2	0
enniatin b	low	1	0
biotin	low	1	0
fosfluconazole	low	1	0
deoxycholic acid	low	6	0
trimethoprim, sulfamethoxazole drug combination	low	1	0
carboplatin	low	1	0
bradykinin	low	1	0
epiglucan	medium	47	1
laminaran	low	4	0
farnesol	low	2	0
mycophenolic acid	low	1	0
clindamycin	low	1	0
zithromax	low	1	0
posaconazole	low	5	0
l 743,872	medium	70	5
streptothricins	low	1	0
glycosides	low	2	0
curcumin	low	1	0
galactomannan	low	1	0
naphthoquinones	low	1	0
bilirubin	medium	1	1
amphotericin b	medium	92	1
oxycodone	low	1	0
butylidenephthalide	medium	1	1
1,5-bis(2-methoxy-4-nitro-5-sulfophenyl)-3-((phenylamino)carbonyl)formazan	low	2	0
cefepime	low	1	0
c.i. fluorescent brightening agent 28	low	1	0
chlorhexidine	low	1	0
formazans	low	2	0
avibactam	low	1	0
nystatin a1	medium	5	1
tannins	medium	1	1
chitosan	low	1	0
amphotericin b, deoxycholate drug combination	low	4	0
piperacillin, tazobactam drug combination	low	1	0
hygromycin b	low	1	0
incb-018424	low	1	0
mannans	low	10	0
interleukin-8	low	2	0
colistin	low	1	0
fructose-1,6-diphosphate	low	1	0
heme	low	1	0
ascorbic acid	low	1	0
minocycline	medium	1	1
tigecycline	low	1	0
calca protein, human	low	3	0
t-2307	low	1	0
caseins	low	1	0
daptomycin	low	1	0
exudates	low	4	0
echinocandin b	low	2	0
rifampin	medium	1	1

Protein Targets (1,306)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain A, JmjC domain-containing histone demethylation protein 3A	5	0	0	5
Chain A, 2-oxoglutarate Oxygenase	9	0	0	9
Chain A, ATP-DEPENDENT DNA HELICASE Q1	3	0	0	3
acetylcholinesterase	10	0	0	10
dopamine D1 receptor	3	0	0	3
15-lipoxygenase, partial	7	0	0	7
pregnane X receptor	6	0	0	6
phosphopantetheinyl transferase	12	0	0	12
RAR-related orphan receptor gamma	13	0	0	13
USP1 protein, partial	10	0	0	10
NFKB1 protein, partial	1	0	0	1
Microtubule-associated protein tau	9	0	0	10
Thrombopoietin	1	0	0	1
AR protein	21	0	0	21
regulator of G-protein signaling 4	1	0	0	1
glucocorticoid receptor [Homo sapiens]	15	0	0	15
retinoic acid nuclear receptor alpha variant 1	13	0	0	13
retinoid X nuclear receptor alpha	16	0	0	16
farnesoid X nuclear receptor	10	0	0	10
estrogen nuclear receptor alpha	25	0	0	25
vitamin D (1,25- dihydroxyvitamin D3) receptor	13	0	0	13
arylsulfatase A	3	0	0	3
euchromatic histone-lysine N-methyltransferase 2	17	0	0	17
Bloom syndrome protein isoform 1	4	0	0	4
D(1A) dopamine receptor	3	0	0	3
thyroid hormone receptor beta isoform a	6	0	0	6
thyroid hormone receptor beta isoform 2	14	0	0	14
heat shock protein beta-1	7	0	0	7
flap endonuclease 1	5	0	0	5
geminin	19	0	0	19
peripheral myelin protein 22	10	0	0	10
survival motor neuron protein isoform d	4	0	0	4
muscarinic acetylcholine receptor M1	1	0	0	1
Histone deacetylase 3	0	3	0	3
Solute carrier family 22 member 6	0	1	0	1
Histone deacetylase 4	0	3	0	3
Guanine nucleotide-binding protein G	3	0	0	3
Histone deacetylase 1	0	4	0	4
Histone deacetylase 7	0	3	0	3
Histone deacetylase 2	0	4	0	4
Polyamine deacetylase HDAC10	0	3	0	3
Histone deacetylase 11	0	3	0	3
Ataxin-2	9	0	0	9
Histone deacetylase 8	0	4	0	4
Histone deacetylase 6	0	4	0	4
Histone deacetylase 9	0	3	0	3
Histone deacetylase 5	0	3	0	3
ATP-dependent phosphofructokinase	5	0	0	5
Putative glycosyltransferase WbgO	0	0	0	1
Cytochrome P450 3A4	0	12	0	13
Cannabinoid receptor 1	0	3	2	5
Killer cell lectin-like receptor subfamily B member 1A	0	1	0	1
Early activation antigen CD69	0	1	0	1
Chain A, HADH2 protein	8	0	0	8
Chain B, HADH2 protein	8	0	0	8
Chain A, Cruzipain	6	0	0	6
interleukin 8	5	0	0	5
GLS protein	5	0	0	5
peroxisome proliferator-activated receptor delta	12	0	0	12
tumor necrosis factor	2	0	0	2
vitamin D3 receptor isoform VDRA	11	0	0	11
nuclear factor erythroid 2-related factor 2 isoform 1	17	0	0	17
lamin isoform A-delta10	16	0	0	16
Cytochrome P450 1A2	0	3	0	3
Cytochrome P450 2D6	0	3	1	4
Cytochrome P450 2C9	0	6	0	6
Cytochrome P450 2C19	0	4	0	4
Nuclear receptor ROR-gamma	6	0	0	6
Potassium voltage-gated channel subfamily H member 2	0	10	0	10
Aurora kinase B	0	1	1	2
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	6	0	7
Replicase polyprotein 1ab	0	3	2	5
Cytochrome P450 2C8	0	2	0	2
Cytochrome P450 2B6	0	2	1	3
thioredoxin reductase	7	0	0	7
ATAD5 protein, partial	4	0	0	4
TDP1 protein	21	0	0	21
estrogen-related nuclear receptor alpha	16	0	0	16
neuropeptide S receptor isoform A	3	0	0	3
Chain A, Hyaluronidase, phage associated	0	1	0	1
GLI family zinc finger 3	12	0	0	12
thioredoxin glutathione reductase	3	0	0	3
cytochrome P450 family 3 subfamily A polypeptide 4	14	0	0	14
IDH1	9	0	0	9
chromobox protein homolog 1	6	0	0	6
nuclear factor erythroid 2-related factor 2 isoform 2	9	0	0	9
lethal(3)malignant brain tumor-like protein 1 isoform I	1	0	0	1
lethal factor (plasmid)	5	0	0	5
Polyphenol oxidase 2	0	1	0	1
Pancreatic alpha-amylase	0	2	0	2
Albumin	0	1	0	1
Urease	0	1	0	1
Prolyl 4-hydroxylase subunit alpha-1	0	0	0	1
Tyrosinase	0	2	0	2
Alpha-2B adrenergic receptor	0	7	1	8
Spike glycoprotein	11	0	1	12
Hyaluronate lyase	0	1	0	1
Prolyl hydroxylase EGLN2	0	0	0	1
Egl nine homolog 1	0	0	0	1
Prolyl hydroxylase EGLN3	0	0	0	1
Hypoxia-inducible factor 1-alpha inhibitor	0	0	0	1
Solute carrier family 23 member 1	0	1	0	1
Beta-lactamase	0	1	0	2
Beta-lactamase	0	2	0	4
Beta-lactamase	0	1	0	2
Beta-lactamase TEM	0	1	0	2
BlaVIM-1	0	1	0	2
Beta-lactamase	0	1	0	1
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	7	0	0	7
Chain A, Putative fructose-1,6-bisphosphate aldolase	5	0	0	5
aldehyde dehydrogenase 1 family, member A1	10	0	0	10
DNA polymerase kappa isoform 1	8	0	0	8
caspase-1 isoform alpha precursor	4	0	0	4
Caspase-7	4	0	0	4
Inositol monophosphatase 1	2	0	0	2
Solute carrier organic anion transporter family member 1B3	0	6	0	10
Solute carrier organic anion transporter family member 1B1	0	6	0	9
Chain A, Avidin	0	0	1	1
Chain A, Protein (streptavidin)	0	0	1	1
Chain B, Protein (streptavidin)	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain D, Streptavidin	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain D, Streptavidin	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain D, Streptavidin	0	0	1	1
Chain A, Streptavidin Complex With Biotin	0	0	1	1
Chain D, Circularly Permuted Core-streptavidin E51/a46	0	0	1	1
Chain A, Core-streptavidin	0	0	1	1
Chain D, Core-streptavidin	0	0	1	1
Chain A, Core-streptavidin	0	0	1	1
Chain D, Core-streptavidin	0	0	1	1
Chain A, Core-streptavidin	0	0	1	1
Chain D, Core-streptavidin	0	0	1	1
Chain A, Core-streptavidin	0	0	1	1
Chain D, Core-streptavidin	0	0	1	1
Chain A, Avidin	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain B, Streptavidin	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain B, Streptavidin	0	0	1	1
apical membrane antigen 1, AMA1	3	0	0	3
nonstructural protein 1	0	1	0	1
green fluorescent protein, partial	0	1	0	1
insulin-degrading enzyme isoform 1	0	0	1	1
Streptavidin	0	0	1	1
Receptor-type tyrosine-protein phosphatase beta	0	0	0	1
histone acetyltransferase KAT2A isoform 1	8	0	0	8
Angiotensin-converting enzyme	0	0	0	1
B2 bradykinin receptor	0	1	0	1
B2 bradykinin receptor	0	2	1	5
B1 bradykinin receptor	0	1	0	1
Olfactory receptor 51E2	0	0	1	1
Alpha-mannosidase	0	1	0	1
Alpha-glucosidase MAL62	0	2	0	2
Oligo-1,6-glucosidase IMA1	0	2	0	2
Tissue alpha-L-fucosidase	0	1	0	1
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	8	0	0	8
estrogen receptor 2 (ER beta)	12	0	0	12
G	10	0	0	10
cytochrome P450 2D6	8	0	0	8
histone-lysine N-methyltransferase 2A isoform 2 precursor	2	0	0	2
Interferon beta	11	0	0	11
HLA class I histocompatibility antigen, B alpha chain	10	0	0	10
Inositol hexakisphosphate kinase 1	10	0	0	10
cytochrome P450 2C9, partial	10	0	0	10
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase type 2	0	0	0	1
Metallo-beta-lactamase VIM-11	0	0	0	1
Metallo-beta-lactamase VIM-2	0	0	0	1
Metallo-beta-lactamase VIM-19	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Solute carrier family 22 member 5	0	1	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase SHV-1	0	0	0	1
Beta-lactamase	0	0	0	1
Kappa-type opioid receptor	0	3	0	5
Solute carrier family 15 member 1	0	1	0	1
Beta-lactamase	0	0	0	1
B2 metallo-beta-lactamase	0	0	0	1
Solute carrier family 15 member 2	0	1	0	1
Metallo-beta-lactamase VIM-13	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase VIM-2	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase	0	0	0	1
Solute carrier family 15 member 2	0	1	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-b-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase class B VIM-2	0	0	0	1
Beta-lactamase VIM-1	0	0	0	1
Chain A, BCL-2-RELATED PROTEIN A1	0	0	2	2
Luciferase	6	0	0	6
acid sphingomyelinase	2	0	0	2
PAX8	0	0	0	1
glp-1 receptor, partial	5	0	0	5
hypoxia-inducible factor 1 alpha subunit	6	0	0	6
SMAD family member 2	5	0	0	5
SMAD family member 3	5	0	0	5
caspase 7, apoptosis-related cysteine protease	4	0	0	4
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	6	0	0	6
PINK1	3	0	0	3
thyroid stimulating hormone receptor	6	0	0	6
nuclear receptor subfamily 1, group I, member 3	10	0	0	10
progesterone receptor	9	0	0	9
pregnane X nuclear receptor	15	0	0	15
67.9K protein	6	0	0	6
glucocerebrosidase	3	0	0	3
Parkin	3	0	0	3
peroxisome proliferator activated receptor gamma	11	0	0	11
heat shock protein 90	0	0	3	3
caspase-3	4	0	0	4
calcineurin A1, putative	0	0	2	2
aryl hydrocarbon receptor	6	0	0	6
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	8	0	0	8
thyroid stimulating hormone receptor	8	0	0	8
activating transcription factor 6	6	0	0	6
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	5	0	0	5
v-jun sarcoma virus 17 oncogene homolog (avian)	7	0	0	7
Histone H2A.x	10	0	0	10
cytochrome P450 2D6 isoform 1	1	0	0	1
hepatocyte nuclear factor 4-alpha isoform 2	0	1	0	1
cellular tumor antigen p53 isoform a	5	0	0	5
cytochrome P450 2C19 precursor	2	0	0	2
cytochrome P450 2C9 precursor	2	0	0	2
perilipin-5	0	2	0	2
perilipin-1	0	2	0	2
potassium voltage-gated channel subfamily H member 2 isoform d	5	0	0	5
transcriptional regulator ERG isoform 3	4	0	0	4
huntingtin isoform 2	5	0	0	5
importin subunit beta-1 isoform 1	5	0	0	5
mitogen-activated protein kinase 1	6	0	0	6
ubiquitin-conjugating enzyme E2 N	0	1	0	1
nuclear factor NF-kappa-B p105 subunit isoform 1	3	0	0	3
protein AF-9 isoform a	0	0	0	1
snurportin-1	5	0	0	5
melanocortin receptor 4	0	1	0	1
CAAX prenyl protease	0	0	0	2
urokinase-type plasminogen activator precursor	4	0	0	4
plasminogen precursor	4	0	0	4
bcl-2-related protein A1	0	1	0	1
urokinase plasminogen activator surface receptor precursor	4	0	0	4
nuclear receptor ROR-gamma isoform 1	5	0	0	5
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform a	0	2	0	2
cytochrome P450 3A4 isoform 1	8	0	0	8
glycogen synthase kinase-3 alpha	0	0	0	1
hexokinase HKDC1	0	1	0	1
DNA repair protein RAD52 homolog isoform a	0	0	0	1
bcl-2-like protein 11 isoform 1	0	0	2	2
Gamma-aminobutyric acid receptor subunit pi	8	2	0	10
Synaptojanin-2	0	1	0	1
Solute carrier family 22 member 2	0	1	0	1
Solute carrier family 22 member 1	0	6	0	7
Polyunsaturated fatty acid lipoxygenase ALOX15B	4	0	0	4
Synaptojanin-1	0	1	0	1
Solute carrier family 22 member 3	0	1	0	1
Voltage-dependent calcium channel gamma-2 subunit	7	0	0	7
Glutathione reductase, mitochondrial	0	1	0	2
Cellular tumor antigen p53	14	0	0	14
Integrin beta-3	5	1	0	6
72 kDa type IV collagenase	0	1	0	1
Integrin alpha-IIb	5	0	0	5
Matrix metalloproteinase-9	0	2	0	2
Gamma-aminobutyric acid receptor subunit beta-1	8	2	0	10
Gamma-aminobutyric acid receptor subunit delta	8	2	0	10
Gamma-aminobutyric acid receptor subunit gamma-2	8	2	0	10
Glutamate receptor 2	7	1	0	8
Gamma-aminobutyric acid receptor subunit alpha-5	8	2	0	10
Gamma-aminobutyric acid receptor subunit alpha-3	8	2	0	10
Gamma-aminobutyric acid receptor subunit gamma-1	8	2	0	10
Gamma-aminobutyric acid receptor subunit alpha-2	8	2	0	10
Gamma-aminobutyric acid receptor subunit alpha-4	8	2	0	10
Gamma-aminobutyric acid receptor subunit gamma-3	8	2	0	10
Trypanothione reductase	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	8	2	0	10
Alpha-synuclein	3	2	1	6
Histamine H2 receptor	5	0	0	5
Gamma-aminobutyric acid receptor subunit alpha-1	8	2	0	10
Gamma-aminobutyric acid receptor subunit beta-3	8	2	0	10
Gamma-aminobutyric acid receptor subunit beta-2	8	2	0	10
TAR DNA-binding protein 43	8	0	0	8
Peroxisomal N(1)-acetyl-spermine/spermidine oxidase	0	1	0	1
Multidrug and toxin extrusion protein 2	0	1	0	1
Rap guanine nucleotide exchange factor 4	1	0	0	1
GABA theta subunit	8	2	0	10
Multidrug and toxin extrusion protein 1	0	2	0	2
ATPase family AAA domain-containing protein 5	7	0	0	7
Gamma-aminobutyric acid receptor subunit epsilon	8	2	0	10
Spermine oxidase	0	1	0	1
Protein-arginine deiminase type-4	0	6	0	6
Chain A, Breast cancer type 1 susceptibility protein	2	0	0	2
Chain A, Ferritin light chain	6	0	0	6
Nrf2	1	0	0	1
alkaline phosphatase, intestinal	0	1	0	1
Smad3	2	0	0	2
EWS/FLI fusion protein	13	0	0	14
bromodomain adjacent to zinc finger domain 2B	2	0	0	2
toll-like receptor 9	0	1	0	1
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	2	0	0	2
TPA: protein transporter TIM10	0	1	0	1
thyrotropin-releasing hormone receptor	2	0	0	2
lysosomal alpha-glucosidase preproprotein	1	0	0	1
alkaline phosphatase, tissue-nonspecific isozyme isoform 1 preproprotein	0	1	0	1
hemoglobin subunit beta	1	0	0	1
polyunsaturated fatty acid lipoxygenase ALOX12	3	0	0	3
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	5	0	0	5
intestinal alkaline phosphatase precursor	0	1	0	1
pyruvate kinase PKM isoform a	1	0	0	1
DNA polymerase beta	3	0	0	3
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	3	0	0	3
tumor susceptibility gene 101 protein	1	0	0	1
GTP-binding nuclear protein Ran isoform 1	2	0	0	2
DNA polymerase iota isoform a (long)	4	0	0	4
muscleblind-like protein 1 isoform 1	4	0	0	4
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	1	0	0	1
alkaline phosphatase, germ cell type preproprotein	0	1	0	1
hypothetical protein SA1422	0	1	0	1
DNA dC->dU-editing enzyme APOBEC-3F isoform a	1	0	0	1
Prostaglandin E synthase	0	1	0	1
Acetylcholinesterase	0	2	0	2
Lysine-specific histone demethylase 1A	0	1	0	1
D-amino-acid oxidase	0	1	0	1
Phospholipase A2	0	1	0	1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	0	2	0	2
Amyloid-beta precursor protein	0	1	0	2
Neuronal proto-oncogene tyrosine-protein kinase Src	0	1	0	1
Prostaglandin G/H synthase 1	0	2	0	2
Cholinesterase	0	1	0	1
Heme oxygenase 1	0	2	0	2
Glutathione S-transferase P	0	1	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	1
60 kDa chaperonin	0	4	0	4
Replicase polyprotein 1ab	0	2	2	4
Microtubule-associated protein tau	0	1	0	2
60 kDa heat shock protein, mitochondrial	0	6	0	6
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2	0	1	0	1
Tissue factor	0	1	0	1
Aminopeptidase N	0	1	0	1
Aminopeptidase N	0	1	0	1
Alpha-1B adrenergic receptor	0	4	0	4
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2	0	2	0	2
Glycogen synthase kinase-3 beta	0	1	0	1
Amine oxidase [flavin-containing] A	0	5	0	5
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Acetylcholinesterase	0	2	0	2
Heme oxygenase 2	0	2	0	2
Alpha-1D adrenergic receptor	0	2	0	2
Amine oxidase [flavin-containing] B	0	6	0	6
Voltage-dependent L-type calcium channel subunit alpha-1D	0	1	0	1
Proteasome subunit beta type-5	0	1	0	1
Prostaglandin G/H synthase 2	0	2	1	3
17-beta-hydroxysteroid dehydrogenase type 2	0	1	0	1
Alpha-1A adrenergic receptor	0	4	0	4
Glycogen synthase kinase-3 beta	0	1	1	2
Beta-secretase 1	0	1	0	1
10 kDa heat shock protein, mitochondrial	0	6	0	6
Cholinesterase	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	1	0	1
Lactoylglutathione lyase	0	1	0	1
Histone acetyltransferase p300	0	1	0	1
Serine/threonine-protein kinase PAK 1	0	1	1	2
5-hydroxytryptamine receptor 4	0	0	1	1
Sodium/bile acid cotransporter	0	1	1	2
Nuclear factor erythroid 2-related factor 2	0	0	1	1
Thiosulfate sulfurtransferase	0	6	0	6
Thioredoxin reductase 1, cytoplasmic	0	1	0	1
60 kDa chaperonin	0	6	0	6
10 kDa chaperonin	0	6	0	6
Thioredoxin reductase 3	0	1	0	1
Sortase A	0	1	0	1
CREB-binding protein	0	1	0	1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 3	0	2	0	2
Cysteine protease	0	1	0	1
NACHT, LRR and PYD domains-containing protein 3	0	1	0	1
Thioredoxin reductase 2, mitochondrial	0	1	0	1
CDGSH iron-sulfur domain-containing protein 1	0	4	0	4
Lymphocyte antigen 96	0	0	1	1
Beta lactamase (plasmid)	0	1	0	1
Chain A, STEROID DELTA-ISOMERASE	0	0	1	1
Steroid Delta-isomerase	0	0	1	1
Vitamin D3 receptor	0	1	1	2
Ileal sodium/bile acid cotransporter	0	1	0	1
G-protein coupled bile acid receptor 1	0	1	1	2
Bile acid receptor	0	0	1	1
Fumarate hydratase	4	0	0	4
GALC protein	2	0	0	2
polyprotein	4	0	0	4
mu-type opioid receptor isoform MOR-1	0	0	1	1
5-hydroxytryptamine receptor 2A	0	0	1	1
Carbonic anhydrase 12	0	1	0	1
Bile salt export pump	0	19	0	19
Epidermal growth factor receptor	0	3	1	4
Carbonic anhydrase 1	0	1	0	1
Carbonic anhydrase 2	0	2	1	3
Tyrosine-protein kinase Lck	0	1	1	2
Tyrosine-protein kinase Fyn	0	3	1	4
Carbonic anhydrase 3	0	1	0	1
Beta-2 adrenergic receptor	0	2	0	2
Aldo-keto reductase family 1 member B1	0	4	0	4
Beta-1 adrenergic receptor	0	2	0	2
Polyunsaturated fatty acid lipoxygenase ALOX15	0	3	0	3
POU domain, class 2, transcription factor 1	0	0	0	1
Carbonic anhydrase 4	0	1	0	1
Carbonic anhydrase 6	0	1	0	1
Sodium-dependent noradrenaline transporter	0	4	0	4
Alpha-1D adrenergic receptor	0	6	0	6
Sodium-dependent serotonin transporter	0	4	0	4
Carbonic anhydrase 5A, mitochondrial	0	1	0	1
D(3) dopamine receptor	0	5	0	5
Carbonic anhydrase 7	0	1	0	1
Sodium-dependent dopamine transporter	0	6	0	6
Carbonic anhydrase 9	0	1	0	1
Carbonic anhydrase 13	0	1	0	1
Sigma non-opioid intracellular receptor 1	0	6	0	6
Carbonic anhydrase 15	0	1	0	1
Carbonic anhydrase 14	0	1	0	1
Carbonic anhydrase 5B, mitochondrial	0	1	0	1
Chain A, Beta-lactamase	2	0	0	2
serine-protein kinase ATM isoform a	1	0	0	1
NPC intracellular cholesterol transporter 1 precursor	2	0	0	2
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	2	0	0	2
ras-related protein Rab-9A	1	0	0	1
eyes absent homolog 2 isoform a	1	0	0	1
Rap guanine nucleotide exchange factor 3	3	0	0	3
Glycoprotein hormones alpha chain	1	0	0	1
Neuraminidase	0	1	0	1
Amine oxidase [flavin-containing] B	0	2	0	2
UDP-glucuronosyltransferase 1A1	0	4	0	5
Amine oxidase [flavin-containing] B	0	1	0	1
Amine oxidase [flavin-containing] B	0	1	0	1
Nuclear receptor subfamily 1 group I member 2	0	0	3	3
ATP-dependent translocase ABCB1	0	6	0	9
D(2) dopamine receptor	0	3	0	3
D(4) dopamine receptor	0	1	0	1
Delta-type opioid receptor	0	2	0	2
Delta-type opioid receptor	0	4	0	4
Mu-type opioid receptor	0	4	1	5
Kappa-type opioid receptor	0	3	0	3
Histamine H1 receptor	0	1	0	1
Mu-type opioid receptor	0	5	2	7
Delta-type opioid receptor	0	6	1	7
Kappa-type opioid receptor	0	4	1	5
Mu-type opioid receptor	0	1	1	2
Mu-type opioid receptor	0	3	0	3
Sigma non-opioid intracellular receptor 1	0	2	0	2
Sigma non-opioid intracellular receptor 1	0	1	0	1
unnamed protein product	0	1	0	1
heat shock protein HSP 90-alpha isoform 2	0	0	0	1
ATP-binding cassette sub-family C member 3	0	16	0	16
Multidrug resistance-associated protein 4	0	17	0	18
Chymotrypsinogen A	0	2	0	2
Beta-lactamase	0	2	0	2
Steroid 17-alpha-hydroxylase/17,20 lyase	0	4	0	4
ATP-dependent translocase ABCB1	0	4	0	4
Lanosterol 14-alpha demethylase	0	1	3	4
Aromatase	0	4	0	4
Cytochrome P450 11B1, mitochondrial	0	3	0	3
Cytochrome P450 11B2, mitochondrial	0	3	0	3
ATP-dependent translocase ABCB1	0	5	0	5
Malate dehydrogenase, cytoplasmic	0	2	0	2
Cytochrome P450 144	0	0	3	3
Steroid C26-monooxygenase	0	0	3	3
Steroid C26-monooxygenase	0	0	3	3
Mycocyclosin synthase	0	0	1	1
Lanosterol 14-alpha demethylase	0	0	1	1
Lanosterol 14-alpha demethylase	0	0	1	1
Lanosterol 14-alpha demethylase	0	5	2	7
Sterol 14-alpha demethylase	0	0	3	3
Sterol 14-alpha demethylase	0	2	2	4
Canalicular multispecific organic anion transporter 1	0	15	0	15
14-alpha sterol demethylase	0	0	3	3
heat shock protein 90, putative	0	0	0	1
likely tRNA 2'-phosphotransferase	0	1	0	1
Skn7p	0	0	0	1
nonstructural protein 1	2	0	0	2
serine/threonine-protein kinase PLK1	1	0	0	1
HSP40, subfamily A [Plasmodium falciparum 3D7]	0	0	0	1
Beta-galactosidase	0	1	0	1
Lipopolysaccharide heptosyltransferase 1	0	1	0	1
PA-I galactophilic lectin	0	0	1	1
Jacalin	0	0	1	1
beta-amyloid peptide, A beta {N-terminal} [human, cerebrospinal fluid, conditioned medium of mixed-brain cell cultures, Peptide Partial, 33 aa]	1	0	0	1
alpha synuclein, partial	1	0	0	1
hypothetical protein, conserved	1	0	0	1
luciferase	1	0	0	1
nuclear receptor subfamily 1, group I, member 2	4	0	0	4
Caspase-7	1	0	0	1
caspase-3	1	0	0	1
histone deacetylase 9 isoform 3	1	0	0	1
ubiquitin carboxyl-terminal hydrolase 2 isoform a	1	0	0	1
Muscarinic acetylcholine receptor M2	0	6	0	6
Muscarinic acetylcholine receptor M4	0	3	0	3
Muscarinic acetylcholine receptor M5	0	3	0	3
Alpha-2A adrenergic receptor	0	6	0	6
Adenosine receptor A3	0	2	0	2
Muscarinic acetylcholine receptor M1	0	3	0	3
Androgen receptor	0	4	0	4
Alpha-2C adrenergic receptor	0	3	0	3
Muscarinic acetylcholine receptor M3	0	3	0	3
Substance-K receptor	0	6	0	6
D(1A) dopamine receptor	0	2	0	2
Glutamate receptor ionotropic, kainate 1	1	0	0	1
Histamine H2 receptor	0	4	0	4
5-hydroxytryptamine receptor 2A	0	2	0	2
Adenosine receptor A2a	0	2	0	2
Glutamate receptor ionotropic, kainate 2	1	0	0	1
Glutamate receptor ionotropic, kainate 3	1	0	0	1
Disintegrin and metalloproteinase domain-containing protein 17	1	0	0	1
Fatty-acid amide hydrolase 1	1	1	0	2
Glutamate receptor ionotropic, kainate 4	1	0	0	1
Leukotriene B4 receptor 1	1	0	0	1
Glutamate receptor ionotropic, kainate 5	1	0	0	1
Leukotriene B4 receptor 2	1	0	0	1
Genome polyprotein	0	1	0	1
Spike glycoprotein	0	0	1	1
Replicase polyprotein 1ab	0	1	1	2
Transmembrane protease serine 2	0	0	1	1
Procathepsin L	0	0	1	1
Replicase polyprotein 1a	0	0	1	1
Replicase polyprotein 1ab	0	0	1	1
Sigma intracellular receptor 2	0	1	0	1
Cyclic GMP-AMP synthase	0	1	0	1
Angiotensin-converting enzyme 2	0	0	1	1
Toll-like receptor 9	0	1	0	1
Toll-like receptor 7	0	1	0	1
Leukotriene C4 synthase	0	0	1	1
tyrosine-protein kinase Yes	2	0	0	2
Bone morphogenetic protein receptor type-1B	0	0	1	1
Cell division cycle 7-related protein kinase	0	0	1	1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	0	0	1	1
Serine/threonine-protein kinase PLK4	0	0	1	1
Serine/threonine-protein kinase 25	0	0	1	1
ATP-dependent RNA helicase DDX3X	0	0	1	1
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta	0	0	1	1
Pyridoxal kinase	0	0	1	1
Citron Rho-interacting kinase	0	0	1	1
Serine/threonine-protein kinase RIO3	0	0	1	1
Dual specificity mitogen-activated protein kinase kinase 7	0	0	1	1
Serine/threonine-protein kinase Chk1	0	0	1	1
Inhibitor of nuclear factor kappa-B kinase subunit beta	0	0	1	1
Peripheral plasma membrane protein CASK	0	0	1	1
Aurora kinase A	0	0	1	1
Cyclin-G-associated kinase	0	1	1	2
Serine/threonine-protein kinase DCLK1	0	0	1	1
Inhibitor of nuclear factor kappa-B kinase subunit alpha	0	0	1	1
Muscle, skeletal receptor tyrosine-protein kinase	0	0	1	1
Ephrin type-B receptor 6	0	0	1	1
Peroxisomal acyl-coenzyme A oxidase 3	0	0	1	1
Mitogen-activated protein kinase 13	0	0	1	1
3-phosphoinositide-dependent protein kinase 1	0	0	1	1
Mitogen-activated protein kinase kinase kinase 13	0	0	1	1
Death-associated protein kinase 3	0	0	1	1
Mitogen-activated protein kinase kinase kinase 7	0	0	1	1
Receptor-interacting serine/threonine-protein kinase 2	0	0	1	1
Mitotic checkpoint serine/threonine-protein kinase BUB1	0	0	1	1
NUAK family SNF1-like kinase 1	0	0	1	1
Dynamin-like 120 kDa protein, mitochondrial	0	0	1	1
Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma	0	0	1	1
Tyrosine-protein kinase JAK2	0	2	2	4
Eukaryotic translation initiation factor 5B	0	0	1	1
Rho-associated protein kinase 2	0	0	1	1
Serine/threonine-protein kinase ULK1	0	0	1	1
Serine/threonine-protein kinase/endoribonuclease IRE1	0	0	1	1
Ribosomal protein S6 kinase alpha-5	0	0	1	1
U5 small nuclear ribonucleoprotein 200 kDa helicase	0	0	1	1
Ribosomal protein S6 kinase alpha-4	0	0	1	1
Serine/threonine-protein kinase 16	0	0	1	1
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	0	0	1	1
Serine/threonine-protein kinase PAK 3	0	0	1	1
Cyclin-dependent kinase-like 5	0	0	1	1
Serine/threonine-protein kinase 17B	0	0	1	1
Serine/threonine-protein kinase 10	0	0	1	1
Serine/threonine-protein kinase D3	0	0	1	1
Cyclin-dependent kinase 14	0	0	1	1
Structural maintenance of chromosomes protein 2	0	0	1	1
Mitogen-activated protein kinase kinase kinase 6	0	0	1	1
Serine/threonine-protein kinase OSR1	0	0	1	1
Mitogen-activated protein kinase kinase kinase kinase 4	0	0	1	1
Serine/threonine-protein kinase LATS1	0	0	1	1
Serine/threonine-protein kinase PAK 4	0	0	1	1
Serine/threonine-protein kinase Chk2	0	0	1	1
Tyrosine-protein kinase ABL1	0	1	2	3
RAF proto-oncogene serine/threonine-protein kinase	0	0	1	1
Receptor tyrosine-protein kinase erbB-2	0	1	1	2
High affinity nerve growth factor receptor	0	0	1	1
Guanine nucleotide-binding protein G(i) subunit alpha-2	0	0	1	1
ADP/ATP translocase 2	0	0	1	1
Protein kinase C beta type	0	0	1	1
Insulin receptor	0	0	1	1
Cyclin-dependent kinase 1	0	0	1	1
Glycogen phosphorylase, liver form	0	0	1	1
Tyrosine-protein kinase Fes/Fps	0	0	1	1
Macrophage colony-stimulating factor 1 receptor	0	0	1	1
Tyrosine-protein kinase Yes	0	0	1	1
Tyrosine-protein kinase Lyn	0	0	1	1
Proto-oncogene tyrosine-protein kinase receptor Ret	0	0	1	1
Insulin-like growth factor 1 receptor	0	0	1	1
Cytochrome c1, heme protein, mitochondrial	0	0	1	1
Hepatocyte growth factor receptor	0	0	1	1
Tyrosine-protein kinase HCK	0	0	1	1
Proto-oncogene tyrosine-protein kinase ROS	0	0	1	1
Platelet-derived growth factor receptor beta	0	0	1	1
Tyrosine-protein kinase Fgr	0	0	1	1
Wee1-like protein kinase 2	0	0	1	1
Uncharacterized serine/threonine-protein kinase SBK3	0	0	1	1
Serine/threonine-protein kinase A-Raf	0	0	1	1
Mast/stem cell growth factor receptor Kit	0	0	1	1
Glycogen phosphorylase, brain form	0	0	1	1
Breakpoint cluster region protein	0	0	1	1
Serine/threonine-protein kinase pim-1	0	0	1	1
Fibroblast growth factor receptor 1	0	1	1	2
Cyclin-dependent kinase 4	0	0	1	1
ADP/ATP translocase 3	0	0	1	1
Inosine-5'-monophosphate dehydrogenase 2	0	2	1	3
Proto-oncogene tyrosine-protein kinase Src	0	1	1	2
cAMP-dependent protein kinase type II-alpha regulatory subunit	0	0	1	1
Insulin receptor-related protein	0	0	1	1
Serine/threonine-protein kinase B-raf	0	0	1	1
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform	0	0	1	1
Ribosyldihydronicotinamide dehydrogenase [quinone]	0	0	1	1
Platelet-derived growth factor receptor alpha	0	0	1	1
Tyrosine-protein kinase Fer	0	0	1	1
Protein kinase C alpha type	0	0	1	1
cAMP-dependent protein kinase catalytic subunit alpha	0	0	1	1
Vascular endothelial growth factor receptor 1	0	0	1	1
General transcription and DNA repair factor IIH helicase subunit XPD	0	0	1	1
Interferon-induced, double-stranded RNA-activated protein kinase	0	0	1	1
Casein kinase II subunit alpha'	0	0	1	1
Serine/threonine-protein kinase MAK	0	0	1	1
Cyclin-dependent kinase 11B	0	0	1	1
Ephrin type-A receptor 1	0	0	1	1
Fibroblast growth factor receptor 2	0	0	1	1
Receptor tyrosine-protein kinase erbB-3	0	0	1	1
Multifunctional protein ADE2	0	0	1	1
Fibroblast growth factor receptor 4	0	0	1	1
Fibroblast growth factor receptor 3	0	0	1	1
cAMP-dependent protein kinase catalytic subunit gamma	0	0	1	1
cAMP-dependent protein kinase catalytic subunit beta	0	0	1	1
Ferrochelatase, mitochondrial	0	0	1	1
Ribosomal protein S6 kinase beta-1	0	0	1	1
Tyrosine-protein kinase JAK1	0	2	2	4
Protein kinase C eta type	0	0	1	1
Cyclin-dependent kinase 2	0	0	2	2
Beta-adrenergic receptor kinase 1	0	0	1	1
Probable ATP-dependent RNA helicase DDX6	0	0	1	1
Activin receptor type-2A	0	0	1	1
Mitogen-activated protein kinase 3	0	0	1	1
MAP/microtubule affinity-regulating kinase 3	0	0	1	1
Deoxycytidine kinase	0	0	1	1
Mitogen-activated protein kinase 1	0	0	1	1
Ephrin type-A receptor 2	0	0	1	1
Ephrin type-A receptor 3	0	0	1	1
Ephrin type-A receptor 8	0	0	1	1
Ephrin type-B receptor 2	0	0	1	1
Leukocyte tyrosine kinase receptor	0	0	1	1
Non-receptor tyrosine-protein kinase TYK2	0	2	2	4
Phosphatidylethanolamine-binding protein 1	0	0	1	1
Wee1-like protein kinase	0	0	1	1
Heme oxygenase 2	0	0	1	1
Tyrosine-protein kinase receptor UFO	0	0	1	1
Mitogen-activated protein kinase 4	0	0	1	1
S-adenosylmethionine synthase isoform type-2	0	0	1	1
DnaJ homolog subfamily A member 1	0	0	1	1
RAC-alpha serine/threonine-protein kinase	0	0	1	1
RAC-beta serine/threonine-protein kinase	0	0	1	1
G protein-coupled receptor kinase 4	0	0	1	1
Dual specificity protein kinase TTK	0	0	1	1
DNA replication licensing factor MCM4	0	0	1	1
Myosin-10	0	0	1	1
Tyrosine-protein kinase receptor Tie-1	0	0	1	1
Vascular endothelial growth factor receptor 3	0	0	1	1
Vascular endothelial growth factor receptor 2	0	0	1	1
Dual specificity mitogen-activated protein kinase kinase 2	0	0	1	1
Receptor-type tyrosine-protein kinase FLT3	0	0	1	1
Bone morphogenetic protein receptor type-1A	0	0	1	1
Activin receptor type-1B	0	0	1	1
TGF-beta receptor type-1	0	0	1	1
Serine/threonine-protein kinase receptor R3	0	0	1	1
TGF-beta receptor type-2	0	0	1	1
Electron transfer flavoprotein subunit beta	0	0	1	1
Tyrosine-protein kinase CSK	0	0	1	1
Glycine--tRNA ligase	0	0	1	1
Protein kinase C iota type	0	0	1	1
Exosome RNA helicase MTR4	0	0	1	1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	0	0	1	1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0	0	1	1
Serine/threonine-protein kinase mTOR	0	0	1	1
Megakaryocyte-associated tyrosine-protein kinase	0	0	1	1
Tyrosine-protein kinase Tec	0	0	1	1
Tyrosine-protein kinase TXK	0	0	1	1
Tyrosine-protein kinase ABL2	0	0	1	1
Tyrosine-protein kinase FRK	0	0	1	1
Tyrosine-protein kinase ZAP-70	0	0	1	1
Tyrosine-protein kinase SYK	0	0	1	1
26S proteasome regulatory subunit 6B	0	0	1	1
Mitogen-activated protein kinase 8	0	0	1	1
Mitogen-activated protein kinase 9	0	0	1	1
Dual specificity mitogen-activated protein kinase kinase 4	0	0	1	1
Dual specificity mitogen-activated protein kinase kinase 3	0	0	1	1
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha	0	0	1	1
Casein kinase I isoform alpha	0	0	1	1
Casein kinase I isoform delta	0	0	1	1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	0	0	1	1
MAP kinase-activated protein kinase 2	0	0	1	1
Cyclin-dependent kinase 8	0	0	1	1
Elongation factor Tu, mitochondrial	0	0	1	1
Cysteine--tRNA ligase, cytoplasmic	0	0	1	1
Casein kinase I isoform epsilon	0	0	1	1
Very long-chain specific acyl-CoA dehydrogenase, mitochondrial	0	0	1	1
Dual specificity protein kinase CLK1	0	0	1	1
Dual specificity protein kinase CLK2	0	0	1	1
Dual specificity protein kinase CLK3	0	0	1	1
Glycogen synthase kinase-3 alpha	0	0	1	1
Cyclin-dependent kinase 7	0	0	1	1
Cyclin-dependent kinase 9	0	0	1	1
Ras-related protein Rab-27A	0	0	1	1
Tyrosine-protein kinase Blk	0	0	1	1
Interleukin-1 receptor-associated kinase 1	0	0	1	1
Ribosomal protein S6 kinase alpha-3	0	0	1	1
Cytoplasmic tyrosine-protein kinase BMX	0	0	1	1
cAMP-dependent protein kinase catalytic subunit PRKX	0	0	1	1
Serine/threonine-protein kinase Nek2	0	0	1	1
Serine/threonine-protein kinase Nek3	0	0	1	1
Serine/threonine-protein kinase Nek4	0	0	1	1
Tyrosine-protein kinase JAK3	0	2	1	3
Dual specificity mitogen-activated protein kinase kinase 6	0	0	1	1
Serine/threonine-protein kinase PLK1	0	0	1	1
Death-associated protein kinase 1	0	0	1	1
LIM domain kinase 1	0	0	1	1
LIM domain kinase 2	0	0	1	1
Mitogen-activated protein kinase 12	0	0	1	1
Mitogen-activated protein kinase 10	0	0	1	1
Tyrosine--tRNA ligase, cytoplasmic	0	0	1	1
5'-AMP-activated protein kinase subunit gamma-1	0	0	1	1
5'-AMP-activated protein kinase catalytic subunit alpha-2	0	0	1	1
Ephrin type-B receptor 3	0	0	1	1
Ephrin type-A receptor 5	0	0	1	1
Ephrin type-B receptor 4	0	0	1	1
Ephrin type-B receptor 1	0	0	1	1
Ephrin type-A receptor 4	0	0	1	1
Adenylate kinase 2, mitochondrial	0	0	1	1
Oxysterols receptor LXR-beta	0	1	0	1
Adenosine kinase	0	0	1	1
Hormonally up-regulated neu tumor-associated kinase	0	0	1	1
Serine/threonine-protein kinase SIK1	0	0	1	1
Receptor-interacting serine/threonine-protein kinase 4	0	0	1	1
Ras-related protein Rab-10	0	0	1	1
Cell division control protein 2 homolog	0	0	1	1
Actin-related protein 3	0	0	1	1
Actin-related protein 2	0	0	1	1
Calcium-dependent protein kinase 1	0	0	1	1
GTP-binding nuclear protein Ran	0	0	1	1
Casein kinase II subunit alpha	0	0	1	1
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta	0	0	1	1
SRSF protein kinase 2	0	0	1	1
Casein kinase I isoform gamma-2	0	0	1	1
Mitogen-activated protein kinase kinase kinase 9	0	0	1	1
Serine/threonine-protein kinase PknB	0	0	1	1
Cyclin-dependent kinase 3	0	0	1	1
Cyclin-dependent kinase-like 1	0	0	1	1
Cyclin-dependent kinase 6	0	0	1	1
Cyclin-dependent-like kinase 5	0	0	1	1
Cyclin-dependent kinase 16	0	0	1	1
Cyclin-dependent kinase 17	0	0	1	1
ATP-dependent 6-phosphofructokinase, platelet type	0	0	1	1
Protein kinase C epsilon type	0	0	1	1
Dual specificity mitogen-activated protein kinase kinase 1	0	0	1	1
Angiopoietin-1 receptor	0	0	1	1
Mitogen-activated protein kinase kinase kinase 10	0	0	1	1
DNA topoisomerase 2-beta	0	0	1	1
Protein kinase C theta type	0	0	1	1
Activin receptor type-1	0	0	1	1
Macrophage-stimulating protein receptor	0	0	1	1
Focal adhesion kinase 1	0	0	1	1
Protein kinase C delta type	0	0	1	1
Tyrosine-protein kinase BTK	0	0	1	1
Tyrosine-protein kinase receptor TYRO3	0	0	1	1
Cyclin-dependent kinase 18	0	0	1	1
Activated CDC42 kinase 1	0	0	1	1
Epithelial discoidin domain-containing receptor 1	0	0	1	1
Tyrosine-protein kinase ITK/TSK	0	0	1	1
Myotonin-protein kinase	0	0	1	1
Mitogen-activated protein kinase kinase kinase kinase 2	0	0	1	1
Mitogen-activated protein kinase kinase kinase 12	0	0	1	1
Tyrosine-protein kinase Mer	0	1	1	2
Serine/threonine-protein kinase 4	0	0	1	1
5'-AMP-activated protein kinase catalytic subunit alpha-1	0	0	1	1
Dual specificity mitogen-activated protein kinase kinase 5	0	0	1	1
Mitogen-activated protein kinase 7	0	0	1	1
Serine/threonine-protein kinase PAK 2	0	0	1	1
Serine/threonine-protein kinase 3	0	0	1	1
Mitogen-activated protein kinase kinase kinase 1	0	0	1	1
cGMP-dependent protein kinase 2	0	0	1	1
Integrin-linked protein kinase	0	0	1	1
Rho-associated protein kinase 1	0	0	1	1
Non-receptor tyrosine-protein kinase TNK1	0	0	1	1
Serine/threonine-protein kinase PRP4 homolog	0	0	1	1
Receptor-interacting serine/threonine-protein kinase 1	0	0	1	1
Calcium/calmodulin-dependent protein kinase type II subunit beta	0	0	1	1
Calcium/calmodulin-dependent protein kinase type II subunit gamma	0	0	1	1
Calcium/calmodulin-dependent protein kinase type II subunit delta	0	0	1	1
Dual specificity tyrosine-phosphorylation-regulated kinase 1A	0	0	1	1
Activin receptor type-2B	0	0	1	1
Bone morphogenetic protein receptor type-2	0	0	1	1
Protein-tyrosine kinase 6	0	0	1	1
cGMP-dependent protein kinase 1	0	0	1	1
Cyclin-dependent kinase 13	0	0	1	1
Calcium/calmodulin-dependent protein kinase type 1	0	0	1	1
Inhibitor of nuclear factor kappa-B kinase subunit epsilon	0	0	1	1
Protein-tyrosine kinase 2-beta	0	0	1	1
Maternal embryonic leucine zipper kinase	0	0	1	1
Structural maintenance of chromosomes protein 1A	0	0	1	1
Chromodomain-helicase-DNA-binding protein 4	0	0	1	1
Peroxisomal acyl-coenzyme A oxidase 1	0	0	1	1
Serine/threonine-protein kinase D1	0	0	1	1
Serine/threonine-protein kinase 38	0	0	1	1
Receptor tyrosine-protein kinase erbB-4	0	0	1	1
Ribosomal protein S6 kinase alpha-2	0	0	1	1
Ephrin type-A receptor 7	0	0	1	1
Delta(24)-sterol reductase	0	0	1	1
Ribosomal protein S6 kinase alpha-1	0	0	1	1
Dual specificity testis-specific protein kinase 1	0	0	1	1
Myosin light chain kinase, smooth muscle	0	0	1	1
Mitogen-activated protein kinase 11	0	0	1	1
Serine/threonine-protein kinase STK11	0	0	1	1
Rhodopsin kinase GRK1	0	0	1	1
NT-3 growth factor receptor	0	0	1	1
Serine/threonine-protein kinase N1	0	0	1	1
Serine/threonine-protein kinase N2	0	0	1	1
Mitogen-activated protein kinase 14	0	0	1	1
Calcium/calmodulin-dependent protein kinase type IV	0	0	1	1
Mitogen-activated protein kinase kinase kinase 11	0	0	1	1
BDNF/NT-3 growth factors receptor	0	0	1	1
Mitogen-activated protein kinase 6	0	0	1	1
Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform	0	0	1	1
Discoidin domain-containing receptor 2	0	0	1	1
AP2-associated protein kinase 1	0	1	1	2
Myosin light chain kinase 3	0	0	1	1
Serine/threonine-protein kinase SBK1	0	0	1	1
Mitogen-activated protein kinase kinase kinase 19	0	0	1	1
Putative heat shock protein HSP 90-beta 2	0	0	1	1
Serine/threonine-protein kinase TNNI3K	0	0	1	1
Leucine-rich repeat serine/threonine-protein kinase 2	0	0	1	1
Serine/threonine-protein kinase MRCK alpha	0	0	1	1
Tyrosine-protein kinase JAK2	0	0	1	1
Serine/threonine-protein kinase MRCK gamma	0	0	1	1
Acyl-CoA dehydrogenase family member 10	0	0	1	1
Serine/threonine-protein kinase Nek5	0	0	1	1
Serine/threonine-protein kinase N3	0	0	1	1
Serine/threonine-protein kinase ULK3	0	0	1	1
Dual serine/threonine and tyrosine protein kinase	0	0	1	1
Mitogen-activated protein kinase kinase kinase 15	0	0	1	1
Uncharacterized protein FLJ45252	0	0	1	1
Acyl-CoA dehydrogenase family member 11	0	0	1	1
Serine/threonine-protein kinase/endoribonuclease IRE2	0	0	1	1
Serine/threonine-protein kinase MARK2	0	0	1	1
Serine/threonine-protein kinase TAO1	0	0	1	1
STE20-related kinase adapter protein alpha	0	0	1	1
Myosin-14	0	0	1	1
AarF domain-containing protein kinase 1	0	0	1	1
Serine/threonine-protein kinase tousled-like 2	0	0	1	1
Serine/threonine-protein kinase 32C	0	0	1	1
Serine/threonine-protein kinase pim-3	0	0	1	1
Serine/threonine-protein kinase VRK2	0	0	1	1
Myosin light chain kinase family member 4	0	0	1	1
Homeodomain-interacting protein kinase 1	0	0	1	1
Calcium/calmodulin-dependent protein kinase type 1D	0	0	1	1
Mitogen-activated protein kinase kinase kinase kinase 3	0	0	1	1
Cyclin-dependent kinase-like 3	0	0	1	1
MAP kinase-activated protein kinase 5	0	0	1	1
Serine/threonine-protein kinase BRSK2	0	0	1	1
Serine/threonine-protein kinase NIM1	0	0	1	1
Eukaryotic peptide chain release factor GTP-binding subunit ERF3B	0	0	1	1
Serine/threonine-protein kinase ULK2	0	0	1	1
Misshapen-like kinase 1	0	0	1	1
Serine/threonine-protein kinase DCLK2	0	0	1	1
Calcium/calmodulin-dependent protein kinase kinase 1	0	0	1	1
Casein kinase I isoform alpha-like	0	0	1	1
Homeodomain-interacting protein kinase 4	0	0	1	1
Myosin-IIIa	0	0	1	1
Ankyrin repeat and protein kinase domain-containing protein 1	0	0	1	1
Serine/threonine-protein kinase Nek11	0	0	1	1
Atypical kinase COQ8A, mitochondrial	0	0	1	1
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma	0	0	1	1
Mitogen-activated protein kinase 15	0	0	1	1
Serine/threonine-protein kinase Nek9	0	0	1	1
Serine/threonine-protein kinase BRSK1	0	0	1	1
Serine/threonine-protein kinase 35	0	0	1	1
Serine/threonine-protein kinase Nek7	0	0	1	1
Rhodopsin kinase GRK7	0	0	1	1
Serine/threonine-protein kinase 32A	0	0	1	1
Myosin-IIIb	0	0	1	1
ATP-dependent RNA helicase DDX1	0	0	1	1
Dual specificity tyrosine-phosphorylation-regulated kinase 2	0	0	1	1
Cyclin-dependent kinase-like 2	0	0	1	1
Mitogen-activated protein kinase kinase kinase kinase 1	0	0	1	1
Serine/threonine-protein kinase Sgk3	0	0	1	1
Atypical kinase COQ8B, mitochondrial	0	0	1	1
MAP/microtubule affinity-regulating kinase 4	0	0	1	1
Calcium/calmodulin-dependent protein kinase type 1G	0	0	1	1
Serine/threonine-protein kinase Nek1	0	0	1	1
Cyclin-dependent kinase 15	0	0	1	1
PAS domain-containing serine/threonine-protein kinase	0	0	1	1
Calcium/calmodulin-dependent protein kinase kinase 2	0	0	1	1
EKC/KEOPS complex subunit TP53RK	0	0	1	1
SRSF protein kinase 1	0	0	1	1
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	0	0	1	1
Mitogen-activated protein kinase kinase kinase 5	0	0	1	1
Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha	0	0	1	1
Mitogen-activated protein kinase kinase kinase 3	0	0	1	1
Eukaryotic translation initiation factor 2-alpha kinase 1	0	0	1	1
Serine/threonine-protein kinase RIO1	0	0	1	1
MAP kinase-interacting serine/threonine-protein kinase 1	0	0	1	1
Serine/threonine-protein kinase RIO2	0	0	1	1
Cyclin-dependent kinase 19	0	0	1	1
Transient receptor potential cation channel subfamily M member 6	0	0	1	1
Testis-specific serine/threonine-protein kinase 1	0	0	1	1
Serine/threonine-protein kinase 33	0	0	1	1
Nucleolar GTP-binding protein 1	0	0	1	1
Serine/threonine-protein kinase D2	0	0	1	1
Serine/threonine-protein kinase DCLK3	0	0	1	1
NUAK family SNF1-like kinase 2	0	0	1	1
RNA cytidine acetyltransferase	0	0	1	1
Serine/threonine-protein kinase SIK2	0	0	1	1
Myosin light chain kinase 2, skeletal/cardiac muscle	0	0	1	1
STE20-like serine/threonine-protein kinase	0	0	1	1
Serine/threonine-protein kinase TAO3	0	0	1	1
Homeodomain-interacting protein kinase 2	0	0	1	1
Tyrosine-protein kinase Srms	0	0	1	1
Homeodomain-interacting protein kinase 3	0	0	1	1
Serine/threonine-protein kinase PLK3	0	0	1	1
dCTP pyrophosphatase 1	0	0	1	1
Dual specificity protein kinase CLK4	0	0	1	1
MAP kinase-interacting serine/threonine-protein kinase 2	0	0	1	1
Serine/threonine-protein kinase Nek6	0	0	1	1
Casein kinase I isoform gamma-1	0	0	1	1
Serine/threonine-protein kinase PAK 6	0	0	1	1
SNF-related serine/threonine-protein kinase	0	0	1	1
Serine/threonine-protein kinase LATS2	0	0	1	1
Serine/threonine-protein kinase 36	0	0	1	1
Phenylalanine--tRNA ligase beta subunit	0	0	1	1
Isoleucine--tRNA ligase, mitochondrial	0	0	1	1
BMP-2-inducible protein kinase	0	0	1	1
Midasin	0	0	1	1
Interleukin-1 receptor-associated kinase 4	0	0	1	1
Serine/threonine-protein kinase 32B	0	0	1	1
Mitogen-activated protein kinase kinase kinase 20	0	0	1	1
Cyclin-dependent kinase 12	0	0	1	1
Serine/threonine-protein kinase PLK2	0	0	1	1
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13	0	0	1	1
Serine/threonine-protein kinase MARK1	0	0	1	1
Serine/threonine-protein kinase pim-2	0	0	1	1
Serine/threonine-protein kinase PAK 5	0	0	1	1
Serine/threonine-protein kinase 26	0	0	1	1
eIF-2-alpha kinase GCN2	0	0	1	1
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial	0	0	1	1
Serine/threonine-protein kinase NLK	0	0	1	1
Phosphatidylinositol 4-kinase beta	0	0	1	1
Serine/threonine-protein kinase 17A	0	0	1	1
STE20/SPS1-related proline-alanine-rich protein kinase	0	0	1	1
Ephrin type-A receptor 6	0	0	1	1
5'-AMP-activated protein kinase subunit gamma-2	0	0	1	1
Serine/threonine-protein kinase TBK1	0	0	1	1
Septin-9	0	0	1	1
Death-associated protein kinase 2	0	0	1	1
Ribosomal protein S6 kinase alpha-6	0	0	1	1
TRAF2 and NCK-interacting protein kinase	0	0	1	1
Serine/threonine-protein kinase tousled-like 1	0	0	1	1
Serine/threonine-protein kinase TAO2	0	0	1	1
ALK tyrosine kinase receptor	0	0	1	1
SRSF protein kinase 3	0	0	1	1
Serine/threonine-protein kinase ICK	0	0	1	1
Cyclin-dependent kinase 11A	0	0	1	1
Aurora kinase C	0	0	1	1
Calcium/calmodulin-dependent protein kinase type II subunit alpha	0	0	1	1
RAC-gamma serine/threonine-protein kinase	0	0	1	1
Serine/threonine-protein kinase 38-like	0	0	1	1
Microtubule-associated serine/threonine-protein kinase 1	0	0	1	1
Serine/threonine-protein kinase SIK3	0	0	1	1
Mitogen-activated protein kinase kinase kinase 2	0	0	1	1
Thyroid hormone receptor-associated protein 3	0	0	1	1
Dual specificity tyrosine-phosphorylation-regulated kinase 1B	0	0	1	1
Mitogen-activated protein kinase kinase kinase kinase 5	0	0	1	1
Receptor-interacting serine/threonine-protein kinase 3	0	0	1	1
Serine/threonine-protein kinase MRCK beta	0	0	1	1
Interleukin-1 receptor-associated kinase 3	0	0	1	1
Serine/threonine-protein kinase 24	0	0	1	1
Casein kinase I isoform gamma-3	0	0	1	1
Mitogen-activated protein kinase kinase kinase 4	0	0	1	1
Estrogen receptor beta	0	1	0	1
25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	0	1	0	1
25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	0	2	0	2
Cytochrome P450 26A1	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
Bile salt export pump	0	6	0	6
3',5'-cyclic-AMP phosphodiesterase	0	1	0	1
Camphor 5-monooxygenase	0	0	0	1
Phospholipase A2, major isoenzyme	0	1	0	1
Epoxide hydrolase 1	0	0	0	1
Cytochrome P450 2C11	0	1	0	1
Steroid 21-hydroxylase	0	1	0	1
Steroid 17-alpha-hydroxylase/17,20 lyase	0	1	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	1
Cholesterol side-chain cleavage enzyme, mitochondrial	0	1	0	1
5-hydroxytryptamine receptor 2A	0	2	0	2
Indoleamine 2,3-dioxygenase 1	0	1	0	1
Cytochrome P450 2A2	0	1	0	1
Cytochrome P450 11B1, mitochondrial	0	2	0	2
Translocator protein	0	2	0	2
Cytochrome P450 7A1	0	1	0	1
Estrogen receptor	0	1	0	1
Thromboxane-A synthase	0	1	0	1
Gonadotropin-releasing hormone receptor	0	1	1	2
Type-1 angiotensin II receptor	0	1	0	1
Cytochrome P450 4F2	0	1	0	1
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial	0	2	0	2
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial	0	1	0	1
Cytochrome P450 7A1	0	1	0	1
Lanosterol 14-alpha demethylase	0	2	0	2
Chain A, AMINOPEPTIDASE	0	1	0	1
Chain A, AMINOPEPTIDASE	0	1	0	1
Chain A, Leucine Aminopeptidase	0	1	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	1	0	1
Intestinal-type alkaline phosphatase	0	1	0	1
Large neutral amino acids transporter small subunit 1	0	2	0	2
Proton-coupled amino acid transporter 1	0	1	0	2
Phospholipase A-2-activating protein	0	1	0	1
CAAX prenyl protease 2 isoform 2	0	0	0	1
streptokinase A precursor	0	0	3	3
Tubulin beta-4A chain	0	2	1	4
Tubulin beta chain	0	2	1	4
Tubulin alpha-3C chain	0	2	1	4
Tubulin alpha-1B chain	0	2	1	4
Tubulin alpha-4A chain	0	2	1	4
Tubulin beta-4B chain	0	2	1	4
DNA gyrase subunit A	0	3	0	4
DNA primase	0	1	0	1
Tubulin beta-3 chain	0	3	1	5
Tubulin beta-2A chain	0	2	1	4
Tubulin beta-8 chain	0	2	1	4
Tubulin alpha-3E chain	0	2	1	4
Tubulin alpha-1A chain	0	2	1	4
Tubulin alpha-1C chain	0	2	1	4
Tubulin beta-6 chain	0	2	1	4
Tubulin beta-2B chain	0	2	1	4
Tubulin beta-1 chain	0	2	1	4
microphthalmia-associated transcription factor isoform 9	0	1	0	1
Solute carrier organic anion transporter family member 2B1	0	2	0	3
Tumor necrosis factor	0	1	0	1
Neuraminidase	0	1	0	1
Platelet-activating factor receptor	1	0	0	1
Cystathionine gamma-lyase	0	1	0	1
Cystine/glutamate transporter	0	1	0	1
Hydroxyacid oxidase 1	0	1	0	1
large T antigen	0	1	0	1
Chain A, Methionyl-tRNA synthetase	0	0	1	1
Chain A, Methionyl-tRNA synthetase	0	0	1	1
Chain A, Aminopeptidase	0	1	0	1
Chain A, Methionine aminopeptidase	0	1	0	1
S-ribosylhomocysteine lyase	0	1	0	1
Adenylate cyclase type 5	0	0	0	1
S-adenosylmethionine synthase isoform type-1	0	0	0	1
S-adenosylmethionine synthase isoform type-2	0	0	0	1
Fatty acid synthase	0	1	0	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
ClpP	1	0	0	1
Thymidylate synthase	0	1	0	1
alpha-galactosidase	1	0	0	1
Thymidylate synthase	0	1	0	1
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]	0	1	0	1
DNA polymerase eta isoform 1	1	0	0	1
transactivating tegument protein VP16 [Human herpesvirus 1]	0	1	0	1
M-phase phosphoprotein 8	1	0	0	1
nuclear receptor coactivator 3 isoform a	0	1	0	1
Toll-like receptor 4	0	1	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
ATP-binding cassette sub-family C member 3	0	1	0	2
Dihydrofolate reductase	0	2	0	3
Dihydrofolate reductase	0	2	0	3
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	2	0	3
Thymidylate synthase	0	1	0	1
Thymidylate synthase	0	2	0	2
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Thymidylate synthase	0	2	0	2
5-hydroxytryptamine receptor 2C	0	1	0	2
High mobility group protein B1	0	0	1	1
Dihydrofolate reductase	0	1	0	1
Thymidylate synthase	0	1	0	1
Dihydrofolate reductase	0	2	2	4
Glucose-6-phosphate 1-dehydrogenase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Folate receptor beta	0	1	0	1
Folate receptor alpha	0	1	0	1
Dihydrofolate reductase	0	2	0	2
Histidine decarboxylase	0	1	0	1
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Bifunctional purine biosynthesis protein ATIC	0	2	0	2
Multidrug resistance-associated protein 1	0	1	0	2
Reduced folate transporter	0	2	0	2
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
6-phosphogluconate dehydrogenase, decarboxylating	0	1	0	1
Solute carrier organic anion transporter family member 1A3	0	0	0	1
Dihydrofolate reductase	0	1	0	1
Pteridine reductase 1	0	1	0	1
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Solute carrier family 22 member 6	0	0	0	1
Canalicular multispecific organic anion transporter 1	0	1	0	2
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Solute carrier family 22 member 20	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Solute carrier family 22 member 8	0	0	0	1
Solute carrier family 22 member 6	0	1	0	1
Dihydrofolate reductase	0	1	0	1
ATP-binding cassette sub-family C member 11	0	0	0	1
Proton-coupled folate transporter	0	1	0	1
Multidrug resistance associated protein	0	1	0	2
Solute carrier family 22 member 11	0	0	0	1
PPM1D protein	3	0	0	3
Glucocorticoid receptor	0	4	1	5
Glycine receptor subunit alpha-1	0	4	0	4
Glycine receptor subunit beta	0	4	0	4
Glycine receptor subunit alpha-2	0	4	0	4
Glycine receptor subunit alpha-3	0	4	0	4
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Thioredoxin reductase	0	1	0	1
Flavodoxin	0	0	0	1
Voltage-dependent L-type calcium channel subunit alpha-1F	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1D	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1S	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1C	0	2	0	2
UDP-glucuronosyltransferase 2B7	0	2	0	2
UDP-glucuronosyltransferase 1-6	0	2	0	2
UDP-glucuronosyltransferase 1A4	0	2	0	2
UDP-glucuronosyltransferase 2B10	0	2	0	2
Albumin	0	0	4	4
Stromelysin-1	0	1	0	1
Matrilysin	0	1	0	1
Multidrug transporter MdfA	0	1	0	1
Cytochrome P450 2J2	0	1	0	1
Protein mono-ADP-ribosyltransferase PARP15	0	1	0	1
Chain A, Inosine-5'-Monophosphate Dehydrogenase 2	0	1	0	1
UDP-glucuronosyltransferase 1A9	0	0	0	1
Glutamate receptor 1	0	1	0	1
Glutamate receptor 3	0	1	0	1
Glutamate receptor 4	0	1	0	1
Inosine-5'-monophosphate dehydrogenase 1	0	2	0	2
Sodium-dependent serotonin transporter	0	2	0	2
Peroxisome proliferator-activated receptor gamma	0	2	3	6
Inosine-5'-monophosphate dehydrogenase	0	1	0	2
UDP-glucuronosyltransferase 1A7	0	0	0	1
UDP-glucuronosyltransferase 1A10	0	0	0	1
UDP-glucuronosyltransferase 1A8	0	0	0	1
STE24	0	0	0	1
Trypsin	0	0	0	1
DNA gyrase subunit A	0	1	0	2
DNA gyrase subunit B	0	1	0	2
DNA gyrase subunit B	0	2	0	3
Kappa-type opioid receptor	0	0	1	1
Genome polyprotein	0	1	0	1
Tubulin alpha-1A chain	0	0	1	2
Tubulin beta chain	0	0	1	1
Integrin alpha-V	0	1	0	1
Botulinum neurotoxin type A	0	1	0	1
Apoptosis regulator Bcl-2	0	1	0	1
Serum paraoxonase/arylesterase 1	0	1	0	1
Cholecystokinin receptor type A	0	2	0	2
Melanocortin receptor 5	0	2	0	2
Bcl-2-like protein 1	0	1	0	1
Beta-tubulin	0	1	0	1
Tubulin beta-2B chain	0	0	1	3
Similar to alpha-tubulin isoform 1	0	0	1	3
Similar to alpha-tubulin isoform 1	0	0	0	2
Nucleotide-binding oligomerization domain-containing protein 2	0	1	0	1
CDGSH iron-sulfur domain-containing protein 1	0	1	0	1
Free fatty acid receptor 1	0	0	1	1
Peroxisome proliferator-activated receptor gamma	0	1	0	1
Muscarinic acetylcholine receptor M1	0	0	1	1
Muscarinic acetylcholine receptor M3	0	0	1	1
Muscarinic acetylcholine receptor M4	0	0	1	1
Steryl-sulfatase	0	1	0	1
Muscarinic acetylcholine receptor M5	0	0	1	1
Muscarinic acetylcholine receptor M2	0	0	1	1
Tyrosine-protein phosphatase non-receptor type 1	0	1	0	1
Carnitine O-palmitoyltransferase 2, mitochondrial	0	1	0	1
Amine oxidase [flavin-containing] A	0	1	0	1
Peroxisome proliferator-activated receptor alpha	0	1	0	1
Carnitine O-palmitoyltransferase 2, mitochondrial	0	1	0	1
Peroxisome proliferator-activated receptor gamma	0	1	1	2
Carnitine O-palmitoyltransferase 1, liver isoform	0	1	0	1
Peroxisome proliferator-activated receptor alpha	0	1	1	2
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	1	0	1
CDGSH iron-sulfur domain-containing protein 2	0	1	0	1
Sterol 14-alpha-demethylase	0	0	2	2
14-alpha sterol demethylase	0	0	2	2
14-alpha sterol demethylase	0	0	2	2
DNA-directed RNA polymerase subunit beta	0	1	0	1
Solute carrier organic anion transporter family member 1A4	0	1	0	1
NH(3)-dependent NAD(+) synthetase	0	1	0	1
Arylacetamide deacetylase	0	1	0	2
Caspase-1	0	1	0	1
Solute carrier organic anion transporter family member 1A1	0	1	0	1
Solute carrier organic anion transporter family member 1A2	0	1	0	1
Glutathione S-transferase omega-1	0	1	0	1
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	1	0	1
DNA-directed RNA polymerase subunit beta	0	1	0	1
Orexin receptor type 1	0	0	0	1
Cathepsin B	0	1	0	1
Fatty acid-binding protein, liver	0	1	0	1
Cannabinoid receptor 1	0	2	2	8
Cannabinoid receptor 2	0	2	1	6
Glutamate receptor ionotropic, NMDA 1	0	1	0	1
Cannabinoid receptor 1	0	2	1	3
Cannabinoid receptor 2	0	0	1	1
C-X-C chemokine receptor type 3	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	1	0	1
Glutamate receptor ionotropic, NMDA 2B	0	1	0	1
Glutamate receptor ionotropic, NMDA 2C	0	1	0	1
N-arachidonyl glycine receptor	0	1	0	1
Glutamate receptor ionotropic, NMDA 2D	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	1	0	1
Glutamate receptor ionotropic, NMDA 3A	0	1	0	1
G-protein coupled receptor 55	0	0	1	1
Alpha-2B adrenergic receptor	0	1	0	1
Alpha-2C adrenergic receptor	0	1	0	1
Alpha-2A adrenergic receptor	0	1	0	1
D-alanyl-D-alanine dipeptidase	0	1	0	1
Transporter	0	1	0	1
Cholesterol side-chain cleavage enzyme, mitochondrial	0	0	1	1
Cholesterol 24-hydroxylase	0	2	1	3
twin arginine protein translocation system - TatA protein	0	0	0	1
30S ribosomal protein S6	0	1	0	1
30S ribosomal protein S7	0	1	0	1
50S ribosomal protein L15	0	1	0	1
50S ribosomal protein L10	0	1	0	1
50S ribosomal protein L11	0	1	0	1
50S ribosomal protein L7/L12	0	1	0	1
50S ribosomal protein L19	0	1	0	1
50S ribosomal protein L1	0	1	0	1
50S ribosomal protein L20	0	1	0	1
50S ribosomal protein L27	0	1	0	1
50S ribosomal protein L28	0	1	0	1
50S ribosomal protein L29	0	1	0	1
50S ribosomal protein L31	0	1	0	1
50S ribosomal protein L31 type B	0	1	0	1
50S ribosomal protein L32	0	1	0	1
50S ribosomal protein L33	0	1	0	1
50S ribosomal protein L34	0	1	0	1
50S ribosomal protein L35	0	1	0	1
50S ribosomal protein L36	0	1	0	1
30S ribosomal protein S10	0	1	0	1
30S ribosomal protein S11	0	1	0	1
30S ribosomal protein S12	0	1	0	1
30S ribosomal protein S13	0	1	0	1
30S ribosomal protein S16	0	1	0	1
30S ribosomal protein S18	0	1	0	1
30S ribosomal protein S19	0	1	0	1
30S ribosomal protein S20	0	1	0	1
30S ribosomal protein S2	0	1	0	1
30S ribosomal protein S3	0	1	0	1
30S ribosomal protein S4	0	1	0	1
30S ribosomal protein S5	0	1	0	1
30S ribosomal protein S8	0	1	0	1
30S ribosomal protein S9	0	1	0	1
50S ribosomal protein L13	0	1	0	1
50S ribosomal protein L14	0	1	0	1
50S ribosomal protein L16	0	1	0	1
50S ribosomal protein L23	0	1	0	1
30S ribosomal protein S15	0	1	0	1
50S ribosomal protein L17	0	1	0	1
50S ribosomal protein L21	0	1	0	1
50S ribosomal protein L30	0	1	0	1
50S ribosomal protein L6	0	1	0	1
30S ribosomal protein S14	0	1	0	1
30S ribosomal protein S17	0	1	0	1
30S ribosomal protein S1	0	1	0	1
50S ribosomal protein L18	0	1	0	1
50S ribosomal protein L2	0	1	0	1
50S ribosomal protein L3	0	1	0	1
50S ribosomal protein L24	0	1	0	1
50S ribosomal protein L4	0	1	0	1
50S ribosomal protein L22	0	1	0	1
50S ribosomal protein L5	0	1	0	1
30S ribosomal protein S21	0	1	0	1
50S ribosomal protein L25	0	1	0	1
50S ribosomal protein L36 2	0	1	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

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Studies (482)

Protein Targets (1,306)

Candidemia

Synonyms(1)

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Overview

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Treatment

Research

Studies (482)

Drugs Studied (105)

Protein Targets (1,306)