Compounds > isoascorbic acid
Page last updated: 2024-08-03 18:25:34

isoascorbic acid

Description

isoascorbic acid: food antioxidant; (L)-isomer is ascorbic acid; RN given refers to (D)-isomer; structure [MeSH]

D-isoascorbic acid : no description available [CHeBI]

Cross-References

ID SourceID
PubMed CID54675810
CHEMBL ID486293
SCHEMBL ID18678
SCHEMBL ID3700961
CHEBI ID51438
MeSH IDM0046353

Synonyms (95)

Synonym
d-erythro-hex-2-enonic acid gamma-lactone
CHEBI:51438 ,
d-erythro-hex-2-enono-1,4-lactone
e315
CHEMBL486293
isoascorbic acid
erythorbic acid
saccharosonic acid
araboascorbic acid
d-erythro-hex-2-enonic acid, .gamma.-lactone
isovitamin c
89-65-6
erycorbin
neo-cebicure
d-araboascorbic acid
glucosaccharonic acid
d-ascorbic acid, iso
nsc-8117
d-erythorbic acid
d-isoascorbic acid
(5r)-5-[(1r)-1,2-dihydroxyethyl]-3,4-dihydroxyfuran-2(5h)-one
einecs 201-928-0
2,3-didehydro-d-erythro-hexono-1,4-lactone
ccris 6568
fema no. 2410
erythroascorbic acid, d-
d-erythro-3-oxohexonic acid lactone
d-erythro-3-ketohexonic acid lactone
brn 0084271
hsdb 584
fema number: 2410
3-keto-d-erythro-hexonic acid gamma-lactone
3-oxohexonic acid lactone, d-erythro-
hex-2-enonic acid gamma-lactone, d-erythro-
nsc 8117
d-erythro-hex-2-enonic acid, gamma-lactone,
mercate 5
d-isoascorbic acid, >=99%, fcc, fg
d-(-)-isoascorbic acid, 98%
1F9G
7179C406-7CCF-4C07-9125-AA71E28FB983
A0520
A843272
ec 201-928-0
erythorbic acid [nf]
unii-311332oii1
5-18-05-00026 (beilstein handbook reference)
311332oii1 ,
NCGC00258663-01
tox21_201111
dtxcid306537
cas-89-65-6
dtxsid6026537 ,
C20364
AKOS015856346
(r)-5-((r)-1,2-dihydroxyethyl)-3,4-dihydroxyfuran-2(5h)-one
isoascorbic-acid
ins-315
ins no.315
erythorbic acid [mart.]
isoascorbic acid [mi]
e-315
erythorbic acid [fhfi]
d-erythro-hex-2-enoic acid gamma-lactone
erythorbic acid [inci]
ascorbic acid impurity f [ep impurity]
erythorbate
erythorbic acid [ii]
erythorbic acid [fcc]
(5r)-5-((1r)-1,2-dihydroxyethyl)-3,4-dihydroxyfuran-2(5h)-one
erythorbic acid [hsdb]
erythorbic acid [usp-rs]
SCHEMBL18678
SCHEMBL3700961
d-(-)-isoascorbic acid
J-506944
mfcd00005378
erythorbic acid, united states pharmacopeia (usp) reference standard
(5r)-5-[(1r)-1,2-dihydroxyethyl]-3,4-dihydroxyfuran-2(5h)-one (d-isoascorbic acid); ascorbic acid impurity f; sodium ascorbate impurity f
(5r)-5-[(1r)-1,2-dihydroxyethyl]-3,4-dihydroxyfuran-2(5h)-one (non-preferred name)
(2r)-2-[(1r)-1,2-dihydroxyethyl]-3,4-dihydroxy-2h-furan-5-one
Q424531
d-erythro-hex-2-enoic acid ?-lactone
Z1255372411
d-iso-ascorbic acid
HY-N7079
CS-0014152
d-erythro-hex-2-enonic acid, g-lactone
AC8021
d-isoascorbic acid 1000 microg/ml in acetonitrile
d(-)-isoascorbic acid (erythorbic acid)
d-soascorbic acid
(5r)-5-[(1r)-1,2-dihydroxyethyl]-3,4-dihydroxyfuran-2(5h)-one (d-isoascorbic acid)
EN300-251979
(5r)-5-[(1r)-1,2-dihydroxyethyl]-3,4-dihydroxy-2,5-dihydrofuran-2-one

Drug Classes (1)

ClassDescription
ascorbic acid

Pathways (1)

isoascorbic acid is involved in 1 pathway(s), involving a total of 0 unique proteins and 466 unique compounds

PathwayProteinsCompounds
Biochemical pathways: part I0466

Protein Targets (3)

Potency Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)
AR proteinHomo sapiens (human)Potency43.7159AID743035
estrogen receptor 2 (ER beta)Homo sapiens (human)Potency24.3613AID1259377

Inhibition Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)
Chain A, HYALURONATE LYASEStreptococcus pneumoniaeKi53,000.0000AID977610

Bioassays (2)

Assay IDTitleYearJournalArticle
AID977610Experimentally measured binding affinity data (Ki) for protein-ligand complexes derived from PDB2001The Journal of biological chemistry, May-04, Volume: 276, Issue:18
ISSN: 0021-9258		Vitamin C inhibits the enzymatic activity of Streptococcus pneumoniae hyaluronate lyase.
AID1811Experimentally measured binding affinity data derived from PDB2001The Journal of biological chemistry, May-04, Volume: 276, Issue:18
ISSN: 0021-9258		Vitamin C inhibits the enzymatic activity of Streptococcus pneumoniae hyaluronate lyase.

Research

Studies (167)

TimeframeStudies, This Drug (%)All Drugs %
pre-199059 (35.33)18.7374
1990's34 (20.36)18.2507
2000's35 (20.96)29.6817
2010's25 (14.97)24.3611
2020's14 (8.38)2.80

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials3 (1.70%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other173 (98.30%)84.16%
SubstanceStudiesClassesRolesFirst YearLast YearAverage AgeRelationship StrengthTrialspre-19901990's2000's2010'spost-2020
ascorbic acid
0
ascorbic acid;
vitamin C		coenzyme;
cofactor;
flour treatment agent;
food antioxidant;
food colour retention agent;
geroprotector;
plant metabolite;
skin lightening agent		00low000000
SubstanceStudiesClassesRolesFirst YearLast YearAverage AgeRelationship StrengthTrialspre-19901990's2000's2010'spost-2020
1-butanol
1
alkyl alcohol;
primary alcohol;
short-chain primary fatty alcohol		human metabolite;
mouse metabolite;
protic solvent		2005200519.0low000100
catechol
1
catecholsallelochemical;
genotoxin;
plant metabolite		1998199826.0low001000
citric acid, anhydrous
2
tricarboxylic acidantimicrobial agent;
chelator;
food acidity regulator;
fundamental metabolite		1988201224.0low010010
gallic acid
2
trihydroxybenzoic acidantineoplastic agent;
antioxidant;
apoptosis inducer;
astringent;
cyclooxygenase 2 inhibitor;
EC 1.13.11.33 (arachidonate 15-lipoxygenase) inhibitor;
geroprotector;
human xenobiotic metabolite;
plant metabolite		2000201317.5low001010
malic acid
1
2-hydroxydicarboxylic acid;
C4-dicarboxylic acid		food acidity regulator;
fundamental metabolite		2012201212.0low000010
lactic acid
1
2-hydroxy monocarboxylic acidalgal metabolite;
Daphnia magna metabolite		1998199826.0low001000
glycine
1
alpha-amino acid;
amino acid zwitterion;
proteinogenic amino acid;
serine family amino acid		EC 2.1.2.1 (glycine hydroxymethyltransferase) inhibitor;
fundamental metabolite;
hepatoprotective agent;
micronutrient;
neurotransmitter;
NMDA receptor agonist;
nutraceutical		2000200024.0low001000
glycerol
1
alditol;
triol		algal metabolite;
detergent;
Escherichia coli metabolite;
geroprotector;
human metabolite;
mouse metabolite;
osmolyte;
Saccharomyces cerevisiae metabolite;
solvent		2008200816.0low000100
hydroquinone
1
benzenediol;
hydroquinones		antioxidant;
carcinogenic agent;
cofactor;
Escherichia coli metabolite;
human xenobiotic metabolite;
mouse metabolite;
skin lightening agent		1998199826.0low001000
pyruvaldehyde
2
2-oxo aldehyde;
propanals		Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite		2013201510.0low000020
phytic acid
1
inositol phosphate202420240.0low000001
niacin
1
pyridine alkaloid;
pyridinemonocarboxylic acid;
vitamin B3		antidote;
antilipemic drug;
EC 3.5.1.19 (nicotinamidase) inhibitor;
Escherichia coli metabolite;
human urinary metabolite;
metabolite;
mouse metabolite;
plant metabolite;
vasodilator agent		1949194975.0low010000
nitrites
3
monovalent inorganic anion;
nitrogen oxoanion;
reactive nitrogen species		human metabolite1987202315.0low010011
oxalic acid
1
alpha,omega-dicarboxylic acidalgal metabolite;
human metabolite;
plant metabolite		1995199529.0low001000
triphosphoric acid
1
acyclic phosphorus acid anhydride;
phosphorus oxoacid		2005200519.0low000100
diphosphoric acid
1
acyclic phosphorus acid anhydride;
phosphorus oxoacid		Escherichia coli metabolite2012201212.0low000010
sulfites
1
divalent inorganic anion;
sulfur oxide;
sulfur oxoanion		2013201311.0low000010
sulfur dioxide
1
sulfur oxideEscherichia coli metabolite;
food bleaching agent;
refrigerant		2013201311.0low000010
uric acid
2
uric acidEscherichia coli metabolite;
human metabolite;
mouse metabolite		1992200028.0low002000
sk&f-38393
1
benzazepine;
catechols;
secondary amino compound		1992199232.0low001000
1-anilino-8-naphthalenesulfonate
3
aminonaphthalene;
naphthalenesulfonic acid		fluorescent probe201520234.3low000012
3-methylcholanthrene
1
ortho- and peri-fused polycyclic arenearyl hydrocarbon receptor agonist;
carcinogenic agent		1991199133.0low001000
p-chloromercuribenzoic acid
1
chlorine molecular entity;
mercuribenzoic acid		1996199628.0low001000
p-aminohippuric acid
1
N-acylglycineDaphnia magna metabolite2006200618.0low000100
theophylline
1
dimethylxanthineadenosine receptor antagonist;
anti-asthmatic drug;
anti-inflammatory agent;
bronchodilator agent;
drug metabolite;
EC 3.1.4.* (phosphoric diester hydrolase) inhibitor;
fungal metabolite;
human blood serum metabolite;
immunomodulator;
muscle relaxant;
vasodilator agent		1980198044.0low010000
anthralin
1
anthracenesantipsoriatic1998199826.0low001000
antipyrine
1
pyrazoloneantipyretic;
cyclooxygenase 3 inhibitor;
environmental contaminant;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug;
xenobiotic		1980198044.0low010000
benzamidine
1
benzenes;
carboxamidine		serine protease inhibitor1987198737.0low010000
caffeine
1
purine alkaloid;
trimethylxanthine		adenosine A2A receptor antagonist;
adenosine receptor antagonist;
adjuvant;
central nervous system stimulant;
diuretic;
EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor;
EC 3.1.4.* (phosphoric diester hydrolase) inhibitor;
environmental contaminant;
food additive;
fungal metabolite;
geroprotector;
human blood serum metabolite;
mouse metabolite;
mutagen;
plant metabolite;
psychotropic drug;
ryanodine receptor agonist;
xenobiotic		1986198638.0low010000
deferoxamine
1
acyclic desferrioxaminebacterial metabolite;
ferroptosis inhibitor;
iron chelator;
siderophore		1998199826.0low001000
ethoxyquin
1
aromatic ether;
quinolines		antifungal agrochemical;
food antioxidant;
genotoxin;
geroprotector;
herbicide;
Hsp90 inhibitor;
neuroprotective agent;
UDP-glucuronosyltransferase activator		1984198440.0low010000
carbonyl cyanide p-trifluoromethoxyphenylhydrazone
2
aromatic ether;
hydrazone;
nitrile;
organofluorine compound		ATP synthase inhibitor;
geroprotector;
ionophore		1981199138.0low011000
haloperidol
1
aromatic ketone;
hydroxypiperidine;
monochlorobenzenes;
organofluorine compound;
tertiary alcohol		antidyskinesia agent;
antiemetic;
dopaminergic antagonist;
first generation antipsychotic;
serotonergic antagonist		1995199529.0low001000
ketamine
1
cyclohexanones;
monochlorobenzenes;
secondary amino compound		analgesic;
environmental contaminant;
intravenous anaesthetic;
neurotoxin;
NMDA receptor antagonist;
xenobiotic		1980198044.0low010000
ethylmaleimide
1
maleimidesanticoronaviral agent;
EC 1.3.1.8 [acyl-CoA dehydrogenase (NADP(+))] inhibitor;
EC 2.1.1.122 [(S)-tetrahydroprotoberberine N-methyltransferase] inhibitor;
EC 2.7.1.1 (hexokinase) inhibitor		1996199628.0low001000
phloretin
1
dihydrochalconesantineoplastic agent;
plant metabolite		1989198935.0low010000
spiperone
1
aromatic ketone;
azaspiro compound;
organofluorine compound;
piperidines;
tertiary amino compound		alpha-adrenergic antagonist;
antipsychotic agent;
dopaminergic antagonist;
psychotropic drug;
serotonergic antagonist		1995199529.0low001000
stearic acid
1
long-chain fatty acid;
saturated fatty acid;
straight-chain saturated fatty acid		algal metabolite;
Daphnia magna metabolite;
human metabolite;
plant metabolite		201520159.0low000010
hydroxyproline
1
4-hydroxyproline;
L-alpha-amino acid zwitterion		human metabolite;
mouse metabolite;
plant metabolite		1981198143.0low010000
cyanides
1
pseudohalide anionEC 1.9.3.1 (cytochrome c oxidase) inhibitor2008200816.0low000100
sucrose
1
glycosyl glycosidealgal metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
osmolyte;
Saccharomyces cerevisiae metabolite;
sweetening agent		1954195470.0low010000
apomorphine
1
aporphine alkaloidalpha-adrenergic drug;
antidyskinesia agent;
antiparkinson drug;
dopamine agonist;
emetic;
serotonergic drug		1988198836.0low010000
galactose
2
D-galactose;
galactopyranose		Escherichia coli metabolite;
mouse metabolite		2000200521.5low001100
edetic acid
3
ethylenediamine derivative;
polyamino carboxylic acid;
tetracarboxylic acid		anticoagulant;
antidote;
chelator;
copper chelator;
geroprotector		1986201821.0low010110
phlorhizin
1
aryl beta-D-glucoside;
dihydrochalcones;
monosaccharide derivative		antioxidant;
plant metabolite		1988198836.0low010000
aniline
1
anilines;
primary arylamine		2000200024.0low001000
methionine
1
aspartate family amino acid;
L-alpha-amino acid;
methionine zwitterion;
methionine;
proteinogenic amino acid		antidote to paracetamol poisoning;
human metabolite;
micronutrient;
mouse metabolite;
nutraceutical		1998199826.0low001000
histidine
1
amino acid zwitterion;
histidine;
L-alpha-amino acid;
polar amino acid zwitterion;
proteinogenic amino acid		algal metabolite;
Escherichia coli metabolite;
human metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
Saccharomyces cerevisiae metabolite		1989198935.0low010000
tert-butylhydroperoxide
1
alkyl hydroperoxideantibacterial agent;
oxidising agent		2000200024.0low001000
acrylamide
1
acrylamides;
N-acylammonia;
primary carboxamide		alkylating agent;
carcinogenic agent;
Maillard reaction product;
mutagen;
neurotoxin		2012201212.0low000010
beta-glucono-1,5-lactone
1
aldono-1,5-lactone;
gluconolactone		animal metabolite;
mouse metabolite		1988198836.0low010000
quinoxalines
1
mancude organic heterobicyclic parent;
naphthyridine;
ortho-fused heteroarene		2000200024.0low001000
cyclohexanol
1
cyclohexanols;
secondary alcohol		solvent2014201410.0low000010
pyrroles
1
pyrrole;
secondary amine		202020204.0low000010
thiophenes
1
mancude organic heteromonocyclic parent;
monocyclic heteroarene;
thiophenes;
volatile organic compound		non-polar solvent1992199232.0low001000
shikimic acid
1
alpha,beta-unsaturated monocarboxylic acid;
cyclohexenecarboxylic acid;
hydroxy monocarboxylic acid		Escherichia coli metabolite;
plant metabolite;
Saccharomyces cerevisiae metabolite		2014201410.0low000010
3-o-methylglucose
1
D-aldohexose derivative1988198836.0low010000
catechin
2
catechinantioxidant;
plant metabolite		1979201029.5low010100
cyclopentane
1
cycloalkane;
cyclopentanes;
volatile organic compound		non-polar solvent2001200123.0low000100
oxazoles
1
1,3-oxazoles;
mancude organic heteromonocyclic parent;
monocyclic heteroarene		2000200024.0low001000
pyrazines
2
diazine;
pyrazines		Daphnia magna metabolite2000200024.0low002000
hydrazine
1
azane;
hydrazines		EC 4.3.1.10 (serine-sulfate ammonia-lyase) inhibitor1998199826.0low001000
copper gluconate
3
organic molecular entity1981198839.0low030000
myristic acid
1
long-chain fatty acid;
straight-chain saturated fatty acid		algal metabolite;
Daphnia magna metabolite;
EC 3.1.1.1 (carboxylesterase) inhibitor;
human metabolite		202120213.0low000001
3-hydroxyflavone
1
flavonols;
monohydroxyflavone		2010201014.0low000100
homoserine
1
amino acid zwitterion;
homoserine		algal metabolite;
Escherichia coli metabolite;
human metabolite;
Saccharomyces cerevisiae metabolite		1998199826.0low001000
cyclopentenone
1
alicyclic ketone;
enone		Hsp70 inducer2001200123.0low000100
2,6-dichloroindophenol
1
dichlorobenzene;
quinone imine		2005200519.0low000100
d-alpha tocopherol
1
alpha-tocopherolalgal metabolite;
antiatherogenic agent;
anticoagulant;
antioxidant;
antiviral agent;
EC 2.7.11.13 (protein kinase C) inhibitor;
immunomodulator;
micronutrient;
nutraceutical;
plant metabolite		2012201212.0low000010
2-tert-butylhydroquinone
1
hydroquinonesfood antioxidant2012201212.0low000010
fucose
1
fucopyranose;
L-fucose		Escherichia coli metabolite;
mouse metabolite		2005200519.0low000100
uridine diphosphate glucuronic acid
1
UDP-D-glucuronic acidEscherichia coli metabolite;
human metabolite;
mouse metabolite		1987198737.0low010000
2,3-diketogulonic acid
2
1981198640.5low020000
mannose
1
D-aldohexose;
D-mannose;
mannopyranose		metabolite2000200024.0low001000
dithiothreitol
2
1,4-dimercaptobutane-2,3-diol;
butanediols;
dithiol;
glycol;
thiol		chelator;
human metabolite;
reducing agent		1989200029.5low011000
butylhydroxybutylnitrosamine
1
nitrosamine;
primary alcohol		carcinogenic agent1984198440.0low010000
gold
1
copper group element atom;
elemental gold		201820186.0low000010
sodium nitrate
1
inorganic nitrate salt;
inorganic sodium salt		fertilizer;
NMR chemical shift reference compound		202320231.0low000001
sodium sulfate
1
inorganic sodium salt2012201212.0low000010
deuterium oxide
1
deuterated compound;
water		NMR solvent2000200024.0low001000
ozone
1
elemental molecule;
gas molecular entity;
reactive oxygen species;
triatomic oxygen		antiseptic drug;
disinfectant;
electrophilic reagent;
greenhouse gas;
mutagen;
oxidising agent;
tracer		2003200321.0low000100
sodium selenite
1
inorganic sodium salt;
selenite salt		nutraceutical2008200816.0low000100
tiletamine hydrochloride
1
2014201410.0low000010
tetradecanoylphorbol acetate
1
acetate ester;
diester;
phorbol ester;
tertiary alpha-hydroxy ketone;
tetradecanoate ester		antineoplastic agent;
apoptosis inducer;
carcinogenic agent;
mitogen;
plant metabolite;
protein kinase C agonist;
reactive oxygen species generator		2008200816.0low000100
sodium azide
1
inorganic sodium saltantibacterial agent;
explosive;
mitochondrial respiratory-chain inhibitor;
mutagen		2006200618.0low000100
azides
1
pseudohalide anionmitochondrial respiratory-chain inhibitor1981198143.0low010000
mifepristone
1
3-oxo-Delta(4) steroid;
acetylenic compound;
tertiary amino compound		abortifacient;
contraceptive drug;
hormone antagonist;
synthetic oral contraceptive		2008200816.0low000100
n 0437, (-)-isomer
1
tetralins1992199232.0low001000
adenosine
1
adenosines;
purines D-ribonucleoside		analgesic;
anti-arrhythmia drug;
fundamental metabolite;
human metabolite;
vasodilator agent		2001200123.0low000100
glucose, (beta-d)-isomer
3
D-glucopyranoseepitope;
mouse metabolite		1990201319.7low001110
aristeromycin
1
2001200123.0low000100
neplanocin a
1
2001200123.0low000100
ethylene diurea
1
2003200321.0low000100
homocysteine
1
amino acid zwitterion;
homocysteine;
serine family amino acid		fundamental metabolite;
mouse metabolite		1998199826.0low001000
2-methyl-1,4-dinitropyrrole
1
202020204.0medium000010
2,5-diketogluconic acid
2
diketoaldonic acidEscherichia coli metabolite1981198640.5high020000
cobalt
1
cobalt group element atom;
metal allergen		micronutrient1949194975.0low010000
dodecyl-beta-d-maltoside
1
disaccharide derivative;
glycoside		detergent1990199034.0low001000
tris(2-carboxyethyl)phosphine
1
phosphine derivative;
tricarboxylic acid		reducing agent2000200024.0low001000
galactonolactone
1
2000200024.0low001000
hydroxyl radical
1
oxygen hydride;
oxygen radical;
reactive oxygen species		1986198638.0low010000
dehydroerythorbic acid
3
1986200128.3high011100
arabinose
6
L-arabinoseEscherichia coli metabolite;
mouse metabolite		1995200624.0low004200
elastin
1
oligopeptide1989198935.0low010000
ouabain
3
11alpha-hydroxy steroid;
14beta-hydroxy steroid;
5beta-hydroxy steroid;
alpha-L-rhamnoside;
cardenolide glycoside;
steroid hormone		anti-arrhythmia drug;
cardiotonic drug;
EC 2.3.3.1 [citrate (Si)-synthase] inhibitor;
EC 3.1.3.41 (4-nitrophenylphosphatase) inhibitor;
EC 3.6.3.10 (H(+)/K(+)-exchanging ATPase) inhibitor;
EC 3.6.3.9 (Na(+)/K(+)-transporting ATPase) inhibitor;
ion transport inhibitor;
plant metabolite		1989200628.7low011100
tartaric acid
1
tartaric acidEscherichia coli metabolite201820186.0low000010
dehydroascorbic acid
21
dehydroascorbic acid;
vitamin C		coenzyme;
mouse metabolite		1979201431.6low0108210
betadex
1
cyclodextrin1998199826.0low001000
retinol
1
retinol;
vitamin A		human metabolite;
mouse metabolite;
plant metabolite		1981198143.0low010000
dactinomycin
1
actinomycinmutagen1981198143.0low010000
potassium permanganate
1
201820186.0low000010
glycosides
1
1998199826.0low001000
sorbic acid
1
alpha,beta-unsaturated monocarboxylic acid;
sorbic acid		202020204.0low000010
pyrophosphate
1
diphosphate ion2012201212.0low000010
curcumin
1
aromatic ether;
beta-diketone;
diarylheptanoid;
enone;
polyphenol		anti-inflammatory agent;
antifungal agent;
antineoplastic agent;
biological pigment;
contraceptive drug;
dye;
EC 1.1.1.205 (IMP dehydrogenase) inhibitor;
EC 1.1.1.21 (aldehyde reductase) inhibitor;
EC 1.1.1.25 (shikimate dehydrogenase) inhibitor;
EC 1.6.5.2 [NAD(P)H dehydrogenase (quinone)] inhibitor;
EC 1.8.1.9 (thioredoxin reductase) inhibitor;
EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor;
EC 3.5.1.98 (histone deacetylase) inhibitor;
flavouring agent;
food colouring;
geroprotector;
hepatoprotective agent;
immunomodulator;
iron chelator;
ligand;
lipoxygenase inhibitor;
metabolite;
neuroprotective agent;
nutraceutical;
radical scavenger		201920195.0low000010
nadp
2
1991199630.5low002000
valinomycin
1
cyclodepsipeptide;
macrocycle		antimicrobial agent;
antiviral agent;
bacterial metabolite;
potassium ionophore		1981198143.0low010000
laccase
1
1998199826.0low001000
quinine
1
cinchona alkaloidantimalarial;
muscle relaxant;
non-narcotic analgesic		1946194678.0low010000
metaphosphoric acid
1
201820186.0low000010
sodium dodecyl sulfate
1
organic sodium saltdetergent;
protein denaturant		1996199628.0low001000
rutin
1
disaccharide derivative;
quercetin O-glucoside;
rutinoside;
tetrahydroxyflavone		antioxidant;
metabolite		1979197945.0low010000
amphotericin b
2
antibiotic antifungal drug;
macrolide antibiotic;
polyene antibiotic		antiamoebic agent;
antiprotozoal drug;
bacterial metabolite		1988198935.5low020000
pulmicort
1
11beta-hydroxy steroid;
20-oxo steroid;
21-hydroxy steroid;
3-oxo-Delta(1),Delta(4)-steroid;
cyclic acetal;
glucocorticoid;
primary alpha-hydroxy ketone		anti-inflammatory drug;
bronchodilator agent;
drug allergen		2008200816.0low000100
monodehydroascorbate
1
organic radicalmouse metabolite1984198440.0low010000
oxalates
1
1995199529.0low001000
pericosine b
1
2014201410.0medium000010
trans-sodium crocetinate
1
1981198143.0low010000
ribose
1
D-ribose;
ribopyranose		2014201410.0low000010
acid phosphatase
3
1988199035.0low021000
nad
2
organophosphate oxoanioncofactor;
human metabolite;
hydrogen acceptor;
Saccharomyces cerevisiae metabolite		1990199133.5low002000
sodium hypochlorite
1
inorganic sodium saltbleaching agent;
disinfectant		202220222.0low000001
sodium bisulfite
1
inorganic sodium salt;
sulfite salt		allergen;
food antioxidant;
food colour retention agent;
mutagen;
reducing agent		2013201311.0low000010
sodium nitrite
3
inorganic sodium salt;
nitrite salt		antidote to cyanide poisoning;
antihypertensive agent;
antimicrobial food preservative;
food antioxidant;
poison		1988202017.0low010020
ascorbic acid
161
ascorbic acid;
vitamin C		coenzyme;
cofactor;
flour treatment agent;
food antioxidant;
food colour retention agent;
geroprotector;
plant metabolite;
skin lightening agent		1946202328.7high3594526256
glucoascorbic acid
2
1949199253.5medium011000
ascorbyl monostearate
1
1987198737.0low010000
ascorbic acid 2-o-glucoside
2
glycoside2007201413.5low000110
rifampin
1
cyclic ketal;
hydrazone;
N-iminopiperazine;
N-methylpiperazine;
rifamycins;
semisynthetic derivative;
zwitterion		angiogenesis inhibitor;
antiamoebic agent;
antineoplastic agent;
antitubercular agent;
DNA synthesis inhibitor;
EC 2.7.7.6 (RNA polymerase) inhibitor;
Escherichia coli metabolite;
geroprotector;
leprostatic drug;
neuroprotective agent;
pregnane X receptor agonist;
protein synthesis inhibitor		1998199826.0low001000
methylnitronitrosoguanidine
2
nitroso compoundalkylating agent1983198540.0low020000
ConditionIndicatedStudiesFirst YearLast YearAverage AgeRelationship StrengthTrialspre-19901990's2000's2010'spost-2020
Adenocarcinoma0
1
1983198341.0low010000
Adenocarcinoma, Basal Cell0
1
1983198341.0low010000
Aging0
1
1984198440.0low010000
Anochlesia0
1
1995199529.0low001000
Anoxemia0
1
1988198836.0low010000
Ascorbic Acid Deficiency0
9
1955200138.8medium053100
Benign Neoplasms0
2
1983198440.5low020000
Bladder Cancer0
3
1984198738.7low030000
Body Weight0
8
1984199835.6medium062000
Cancer of Stomach0
2
1983198540.0low020000
Candida Infection0
1
2001200123.0low000100
Candidiasis0
1
2001200123.0low000100
Carcinoma, Epidermoid0
1
1983198341.0low010000
Carcinoma, Squamous Cell0
1
1983198341.0low010000
Cell Transformation, Neoplastic0
1
1991199133.0low001000
Cocarcinogenesis0
3
1984198738.7low030000
Deficiency, Ascorbic Acid0
9
1955200138.8medium053100
Dehydration0
1
201920195.0low000010
Electrolytes0
1
1984198440.0low010000
Erythrocytosis0
1
1949194975.0low010000
Hyperplasia0
1
1984198440.0low010000
Hypoascorbemia0
4
1955200144.5low030100
Hypoxia0
1
1988198836.0low010000
Infections, Plasmodium0
1
1995199529.0low001000
Leukemia, Lymphocytic0
1
1984198440.0low010000
Leukemia, Lymphoid0
1
1984198440.0low010000
Malaria0
1
1995199529.0low001000
Neoplasms0
2
1983198440.5low020000
Papilloma0
1
1984198440.0low010000
Papilloma, Squamous Cell0
1
1984198440.0low010000
Pregnancy0
1
1983198341.0low010000
Sarcoma0
1
1983198341.0low010000
Sarcoma, Epithelioid0
1
1983198341.0low010000
Scurvy0
4
1955200144.5low030100
Sensitivity and Specificity0
1
201820186.0low000010
Stomach Neoplasms0
2
1983198540.0low020000
Sunburn0
1
1992199232.0low001000
Urinary Bladder Neoplasms0
3
1984198738.7low030000

Safety/Toxicity (2)

ArticleYear
Role of hydrogen peroxide in cytotoxicity induction by ascorbates and other redox compounds.
Anticancer research, , Volume: 18, Issue:6A
Cytotoxic effect of ascorbate and its derivatives on cultured malignant and nonmalignant cell lines.
Anticancer research, , Volume: 13, Issue:2

Pharmacokinetics (1)

ArticleYear
Effect of smoking on erythorbic acid pharmacokinetics.
The British journal of nutrition, , Volume: 89, Issue:5		2003

Bioavailability (5)

ArticleYear
Erythorbic acid is a potent enhancer of nonheme-iron absorption.
The American journal of clinical nutrition, , Volume: 79, Issue:1		2004
Effect of smoking on erythorbic acid pharmacokinetics.
The British journal of nutrition, , Volume: 89, Issue:5		2003
The antiscorbutic action of L-ascorbic acid and D-isoascorbic acid (erythorbic acid) in the guinea pig.
The American journal of clinical nutrition, , Volume: 34, Issue:1		1981
Influence of erythorbic acid on ascorbic acid retention and elimination in the mouse.
International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition, , Volume: 53, Issue:3		1983
Comparison of absorption of erythorbic acid and ascorbic acid in guinea pig small intestine.
Journal of nutritional science and vitaminology, , Volume: 37, Issue:5		1991