Roles > dopaminergic agent
Page last updated: 2024-08-05 15:08:49

dopaminergic agent

A drug used for its effects on dopamine receptors, on the life cycle of dopamine, or on the survival of dopaminergic neurons.

ChEBI ID: 48560

Members (12)

MemberDefinitionClass
amantadineA member of the class of adamantanes that is used as an antiviral and antiparkinson drug.amantadine
auraptenA member of the class of coumarins that is umbelliferone in which the phenolic hydrogen has been replaced by a geranyl group. Ii is isolated from several edible fruits and vegetables and exhibits a variety of therapeutic properties.auraptene
benserazideA carbohydrazide that results from the formal condensation of the carboxy group of DL-serine with the primary amino group of 4-(hydrazinylmethyl)benzene-1,2,3-triol. An aromatic-L-amino-acid decarboxylase inhibitor (DOPA decarboxylase inhibitor) that does not enter the central nervous system, it is used as its hydrochloride salt as an adjunct to levodopa in the treatment of parkinsonism. By preventing the conversion of levodopa to dopamine in the periphery, it causes an increase in the amount of levodopa reaching the central nervous system and so reduces the required dose. Benserazide has no antiparkinson actions when given alone.benserazide
benserazide hydrochlorideA hydrochloride that is the monohydrochloride salt of benserazide. An aromatic-L-amino-acid decarboxylase inhibitor (DOPA decarboxylase inhibitor) that does not enter the central nervous system, it is used as an adjunct to levodopa in the treatment of parkinsonism. By preventing the conversion of levodopa to dopamine in the periphery, it causes an increase in the amount of levodopa reaching the central nervous system and so reduces the required dose. Benserazide hydrochloride has no antiparkinson actions when given alone.benserazide hydrochloride
carbidopa3-(3,4-Dihydroxyphenyl)propanoic acid in which the hydrogens alpha- to the carboxyl group are substituted by hydrazinyl and methyl groups (S-configuration). Carbidopa is a dopa decarboxylase inhibitor, so prevents conversion of levodopa to dopamine. It has no antiparkinson activity by itself, but is used (commonly as its hydrate) in the management of Parkinson's disease to reduce peripheral adverse effects of levodopa.carbidopa (anhydrous)
carbidopaThe hydrate of 3-(3,4-dihydroxyphenyl)propanoic acid in which the hydrogens alpha- to the carboxyl group are substituted by hydrazinyl and methyl groups (S-configuration). Carbidopa is a dopa decarboxylase inhibitor, so prevents conversion of levodopa to dopamine. It has no antiparkinson activity by itself, but is used in the management of Parkinson's disease to reduce peripheral adverse effects of levodopa.carbidopa
dextroamphetamineA 1-phenylpropan-2-amine that has S configuration.(S)-amphetamine
levodopaAn optically active form of dopa having L-configuration. Used to treat the stiffness, tremors, spasms, and poor muscle control of Parkinson's diseaseL-dopa zwitterion; L-dopa
memantineA primary aliphatic amine that is the 3,5-dimethyl derivative of 1-aminoadamantane. A low to moderate affinity uncompetitive (open-channel); NMDA receptor antagonist which binds preferentially to the NMDA receptor-operated cation channels.memantine
memantine hydrochlorideA hydrochloride obtained by reaction of memantine with one equivalent of hydrochloric acid. A low to moderate affinity uncompetitive (open-channel); NMDA receptor antagonist which binds preferentially to the NMDA receptor-operated cation channels.memantine hydrochloride
phenterminephentermine
selegiline hydrochloride, (r)-isomerselegiline hydrochloride

Research

Studies (30,389)

TimeframeStudies, Drugs with This Role(%)All Drugs %
pre-199010,564 (34.76)18.7374
1990's4,874 (16.04)18.2507
2000's6,253 (20.58)29.6817
2010's6,573 (21.63)24.3611
2020's2,125 (6.99)2.80

Study Types

Publication TypeStudies, Drugs with this Role (%)All Drugs (%)
Trials3,698 (10.92%)5.53%
Reviews3,753 (11.09%)6.00%
Case Studies2,694 (7.96%)4.05%
Observational114 (0.34%)0.25%
Other23,592 (69.69%)84.16%

Protein Targets (305)

Potency Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1Homo sapiens (human)Potency31.497215
15-lipoxygenase, partialHomo sapiens (human)Potency21.895912
acetylcholinesteraseHomo sapiens (human)Potency0.870911
acid sphingomyelinaseHomo sapiens (human)Potency31.622811
aldehyde dehydrogenase 1 family, member A1Homo sapiens (human)Potency25.595219
alpha-galactosidaseHomo sapiens (human)Potency14.125411
apical membrane antigen 1, AMA1Plasmodium falciparum 3D7Potency10.366414
AR proteinHomo sapiens (human)Potency17.2879911
aryl hydrocarbon receptorHomo sapiens (human)Potency15.285422
arylsulfatase AHomo sapiens (human)Potency20.656912
ATP-dependent phosphofructokinaseTrypanosoma brucei brucei TREU927Potency9.154224
atrial natriuretic peptide receptor 1 precursorHomo sapiens (human)Potency23.934111
Bloom syndrome protein isoform 1Homo sapiens (human)Potency1.358011
bromodomain adjacent to zinc finger domain 2BHomo sapiens (human)Potency30.350412
Chain A, 2-oxoglutarate OxygenaseHomo sapiens (human)Potency12.344018
Chain A, ATP-DEPENDENT DNA HELICASE Q1Homo sapiens (human)Potency12.589311
Chain A, Beta-lactamaseEscherichia coli K-12Potency24.361612
Chain A, HADH2 proteinHomo sapiens (human)Potency13.540325
Chain A, JmjC domain-containing histone demethylation protein 3AHomo sapiens (human)Potency48.342315
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASEHomo sapiens (human)Potency17.585914
Chain A, Putative fructose-1,6-bisphosphate aldolaseGiardia intestinalisPotency12.656616
Chain A, TYROSYL-DNA PHOSPHODIESTERASEHomo sapiens (human)Potency15.200616
Chain B, HADH2 proteinHomo sapiens (human)Potency13.540325
chromobox protein homolog 1Homo sapiens (human)Potency49.811528
cytochrome P450 2C9, partialHomo sapiens (human)Potency25.444812
cytochrome P450 2D6Homo sapiens (human)Potency28.096213
cytochrome P450 3A4 isoform 1Homo sapiens (human)Potency39.810724
cytochrome P450 family 3 subfamily A polypeptide 4Homo sapiens (human)Potency30.111611
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_aHomo sapiens (human)Potency14.146612
D(1A) dopamine receptorSus scrofa (pig)Potency23.280911
DNA polymerase betaHomo sapiens (human)Potency40.436713
DNA polymerase eta isoform 1Homo sapiens (human)Potency42.772223
DNA polymerase iota isoform a (long)Homo sapiens (human)Potency32.257226
DNA polymerase kappa isoform 1Homo sapiens (human)Potency10.501514
dopamine D1 receptorHomo sapiens (human)Potency8.199511
endonuclease IVEscherichia coliPotency27.944312
estrogen nuclear receptor alphaHomo sapiens (human)Potency24.290222
estrogen-related nuclear receptor alphaHomo sapiens (human)Potency10.590911
euchromatic histone-lysine N-methyltransferase 2Homo sapiens (human)Potency8.0364110
EWS/FLI fusion proteinHomo sapiens (human)Potency24.104649
flap endonuclease 1Homo sapiens (human)Potency23.108335
GVesicular stomatitis virusPotency25.444812
GABA theta subunitRattus norvegicus (Norway rat)Potency39.810712
Gamma-aminobutyric acid receptor subunit alpha-1Rattus norvegicus (Norway rat)Potency39.810712
Gamma-aminobutyric acid receptor subunit alpha-2Rattus norvegicus (Norway rat)Potency39.810712
Gamma-aminobutyric acid receptor subunit alpha-3Rattus norvegicus (Norway rat)Potency39.810712
Gamma-aminobutyric acid receptor subunit alpha-4Rattus norvegicus (Norway rat)Potency39.810712
Gamma-aminobutyric acid receptor subunit alpha-5Rattus norvegicus (Norway rat)Potency39.810712
Gamma-aminobutyric acid receptor subunit alpha-6Rattus norvegicus (Norway rat)Potency39.810712
Gamma-aminobutyric acid receptor subunit beta-1Rattus norvegicus (Norway rat)Potency39.810712
Gamma-aminobutyric acid receptor subunit beta-2Rattus norvegicus (Norway rat)Potency39.810712
Gamma-aminobutyric acid receptor subunit beta-3Rattus norvegicus (Norway rat)Potency39.810712
Gamma-aminobutyric acid receptor subunit deltaRattus norvegicus (Norway rat)Potency39.810712
Gamma-aminobutyric acid receptor subunit epsilonRattus norvegicus (Norway rat)Potency39.810712
Gamma-aminobutyric acid receptor subunit gamma-1Rattus norvegicus (Norway rat)Potency39.810712
Gamma-aminobutyric acid receptor subunit gamma-2Rattus norvegicus (Norway rat)Potency39.810712
Gamma-aminobutyric acid receptor subunit gamma-3Rattus norvegicus (Norway rat)Potency39.810712
Gamma-aminobutyric acid receptor subunit piRattus norvegicus (Norway rat)Potency39.810712
gemininHomo sapiens (human)Potency10.845528
GLI family zinc finger 3Homo sapiens (human)Potency8.371325
glp-1 receptor, partialHomo sapiens (human)Potency19.952611
GLS proteinHomo sapiens (human)Potency27.188426
glucocerebrosidaseHomo sapiens (human)Potency31.622811
glucocorticoid receptor [Homo sapiens]Homo sapiens (human)Potency6.373512
glucokinase regulatory proteinHomo sapiens (human)Potency5.011911
heat shock protein beta-1Homo sapiens (human)Potency13.332211
hexokinase-4 isoform 1Homo sapiens (human)Potency5.011911
Histamine H2 receptorCavia porcellus (domestic guinea pig)Potency22.387212
histone acetyltransferase KAT2A isoform 1Homo sapiens (human)Potency39.810711
Histone H2A.xCricetulus griseus (Chinese hamster)Potency34.826711
HLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)Potency25.444812
huntingtin isoform 2Homo sapiens (human)Potency35.481311
hypothetical protein, conservedTrypanosoma bruceiPotency14.125411
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)Homo sapiens (human)Potency10.000022
IDH1Homo sapiens (human)Potency6.513111
importin subunit beta-1 isoform 1Homo sapiens (human)Potency56.234111
Inositol hexakisphosphate kinase 1Homo sapiens (human)Potency25.444814
Inositol monophosphatase 1Rattus norvegicus (Norway rat)Potency31.622811
Interferon betaHomo sapiens (human)Potency25.444812
lamin isoform A-delta10Homo sapiens (human)Potency9.145615
lethal(3)malignant brain tumor-like protein 1 isoform IHomo sapiens (human)Potency31.622811
LuciferasePhotinus pyralis (common eastern firefly)Potency26.401423
lysosomal alpha-glucosidase preproproteinHomo sapiens (human)Potency3.138111
M-phase phosphoprotein 8Homo sapiens (human)Potency14.264215
Microtubule-associated protein tauHomo sapiens (human)Potency13.7437213
mitogen-activated protein kinase 1Homo sapiens (human)Potency16.616823
muscarinic acetylcholine receptor M1Rattus norvegicus (Norway rat)Potency0.070811
neuropeptide S receptor isoform AHomo sapiens (human)Potency5.011912
NFKB1 protein, partialHomo sapiens (human)Potency2.818422
nonstructural protein 1Influenza A virus (A/WSN/1933(H1N1))Potency25.118911
nuclear factor erythroid 2-related factor 2 isoform 2Homo sapiens (human)Potency23.109311
nuclear receptor ROR-gamma isoform 1Mus musculus (house mouse)Potency7.079511
parathyroid hormone/parathyroid hormone-related peptide receptor precursorHomo sapiens (human)Potency79.432811
ParkinHomo sapiens (human)Potency44.668411
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1Homo sapiens (human)Potency63.529022
peripheral myelin protein 22Rattus norvegicus (Norway rat)Potency14.630825
peripheral myelin protein 22 isoform 1Homo sapiens (human)Potency84.921412
phosphoglycerate kinaseTrypanosoma brucei brucei TREU927Potency12.173933
phosphopantetheinyl transferaseBacillus subtilisPotency46.719239
PINK1Homo sapiens (human)Potency44.668411
Polyunsaturated fatty acid lipoxygenase ALOX15BHomo sapiens (human)Potency22.387211
pregnane X nuclear receptorHomo sapiens (human)Potency11.883211
progesterone receptorHomo sapiens (human)Potency16.785511
putative alpha-glucosidaseOryza sativa Japonica Group (Japanese rice)Potency28.183812
pyruvate kinaseLeishmania mexicana mexicanaPotency25.118922
RAR-related orphan receptor gammaMus musculus (house mouse)Potency30.047412
regulator of G-protein signaling 4Homo sapiens (human)Potency16.437814
retinoic acid nuclear receptor alpha variant 1Homo sapiens (human)Potency22.366333
serine-protein kinase ATM isoform aHomo sapiens (human)Potency22.387211
serine/threonine-protein kinase mTOR isoform 1Homo sapiens (human)Potency18.654623
serine/threonine-protein kinase PLK1Homo sapiens (human)Potency6.701611
signal transducer and activator of transcription 6, interleukin-4 inducedHomo sapiens (human)Potency100.000011
Smad3Homo sapiens (human)Potency35.481311
snurportin-1Homo sapiens (human)Potency56.234111
Spike glycoproteinSevere acute respiratory syndrome-related coronavirusPotency0.631011
survival motor neuron protein isoform dHomo sapiens (human)Potency1.122011
TAR DNA-binding protein 43Homo sapiens (human)Potency10.000011
TDP1 proteinHomo sapiens (human)Potency17.7301215
thioredoxin glutathione reductaseSchistosoma mansoniPotency0.316211
thioredoxin reductaseRattus norvegicus (Norway rat)Potency12.9648314
ThrombopoietinHomo sapiens (human)Potency25.118922
thyroid hormone receptor beta isoform 2Rattus norvegicus (Norway rat)Potency31.670424
thyroid stimulating hormone receptorHomo sapiens (human)Potency6.309622
transcriptional regulator ERG isoform 3Homo sapiens (human)Potency50.118711
transient receptor potential cation channel subfamily V member 1Homo sapiens (human)Potency19.952611
ubiquitin carboxyl-terminal hydrolase 2 isoform aHomo sapiens (human)Potency20.749111
USP1 protein, partialHomo sapiens (human)Potency61.723323
vitamin D (1,25- dihydroxyvitamin D3) receptorHomo sapiens (human)Potency0.196222
vitamin D3 receptor isoform VDRAHomo sapiens (human)Potency71.005214
WRNHomo sapiens (human)Potency5.497922

Inhibition Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
5-hydroxytryptamine receptor 7Cavia porcellus (domestic guinea pig)IC5027.200012
AcetylcholinesteraseElectrophorus electricus (electric eel)IC5010.000011
AcetylcholinesteraseHomo sapiens (human)IC500.004911
Acyl carrier protein, mitochondrialHomo sapiens (human)IC5014.500022
Amine oxidase [flavin-containing] AHomo sapiens (human)IC501.700011
Amine oxidase [flavin-containing] AMus musculus (house mouse)IC500.000011
Amine oxidase [flavin-containing] AHomo sapiens (human)Ki14.400011
Amine oxidase [flavin-containing] A Rattus norvegicus (Norway rat)IC500.944011
Amine oxidase [flavin-containing] BHomo sapiens (human)IC500.006722
Amine oxidase [flavin-containing] BMus musculus (house mouse)IC500.300022
Amine oxidase [flavin-containing] BRattus norvegicus (Norway rat)IC500.006822
Amine oxidase [flavin-containing] BBos taurus (cattle)Ki300.000011
Amine oxidase [flavin-containing] BHomo sapiens (human)Ki280.000011
Amine oxidase [flavin-containing] BRattus norvegicus (Norway rat)Ki370.000022
ATP-binding cassette sub-family C member 3Homo sapiens (human)IC50133.000013
Beta-secretase 1Homo sapiens (human)IC50345.100011
Bile salt export pumpHomo sapiens (human)IC50378.657137
Canalicular multispecific organic anion transporter 1Homo sapiens (human)IC50133.000013
CholinesteraseEquus caballus (horse)IC5010.000011
Complex I intermediate-associated protein 30, mitochondrialHomo sapiens (human)IC5014.500022
Cytochrome c oxidase subunit NDUFA4Homo sapiens (human)IC5014.500022
Cytochrome P450 2C9 Homo sapiens (human)IC501.376111
DNA dC->dU-editing enzyme APOBEC-3G isoform 1Homo sapiens (human)IC501.490011
Epidermal growth factor receptorHomo sapiens (human)IC50451.440022
estrogen receptor beta isoform 1Homo sapiens (human)IC503.054011
Genome polyproteinCoxsackievirus B3 (strain Nancy)IC502.400011
Glutamate receptor ionotropic, NMDA 1Homo sapiens (human)IC504.13741111
Glutamate receptor ionotropic, NMDA 1Homo sapiens (human)Ki3.145034
Glutamate receptor ionotropic, NMDA 1 Rattus norvegicus (Norway rat)IC5070.07241319
Glutamate receptor ionotropic, NMDA 1 Rattus norvegicus (Norway rat)Ki0.700011
Glutamate receptor ionotropic, NMDA 2AHomo sapiens (human)IC503.467477
Glutamate receptor ionotropic, NMDA 2AHomo sapiens (human)Ki3.860023
Glutamate receptor ionotropic, NMDA 2A Rattus norvegicus (Norway rat)IC5073.84871218
Glutamate receptor ionotropic, NMDA 2A Rattus norvegicus (Norway rat)Ki0.700011
Glutamate receptor ionotropic, NMDA 2BHomo sapiens (human)IC505.310044
Glutamate receptor ionotropic, NMDA 2BRattus norvegicus (Norway rat)IC5080.56241116
Glutamate receptor ionotropic, NMDA 2BHomo sapiens (human)Ki3.145034
Glutamate receptor ionotropic, NMDA 2BRattus norvegicus (Norway rat)Ki0.700011
Glutamate receptor ionotropic, NMDA 2CRattus norvegicus (Norway rat)IC5085.79331015
Glutamate receptor ionotropic, NMDA 2CHomo sapiens (human)Ki3.860023
Glutamate receptor ionotropic, NMDA 2CRattus norvegicus (Norway rat)Ki0.700012
Glutamate receptor ionotropic, NMDA 2DRattus norvegicus (Norway rat)IC5085.79331015
Glutamate receptor ionotropic, NMDA 2DHomo sapiens (human)Ki3.860023
Glutamate receptor ionotropic, NMDA 2DRattus norvegicus (Norway rat)Ki0.700011
Glutamate receptor ionotropic, NMDA 3ARattus norvegicus (Norway rat)IC5085.79331015
Glutamate receptor ionotropic, NMDA 3AHomo sapiens (human)Ki3.860023
Glutamate receptor ionotropic, NMDA 3ARattus norvegicus (Norway rat)Ki0.700011
Glutamate receptor ionotropic, NMDA 3BRattus norvegicus (Norway rat)IC5085.79331015
Glutamate receptor ionotropic, NMDA 3BHomo sapiens (human)Ki3.860023
Glutamate receptor ionotropic, NMDA 3BRattus norvegicus (Norway rat)Ki0.700011
Hexokinase-2Homo sapiens (human)IC505.520011
integrase, partialHuman immunodeficiency virus 1IC500.593922
intestinal alkaline phosphatase precursorMus musculus (house mouse)IC5050.900011
Large neutral amino acids transporter small subunit 1Homo sapiens (human)IC50100.000011
lens epithelium-derived growth factor p75Homo sapiens (human)IC500.593922
Lysine-specific demethylase 4EHomo sapiens (human)Ki1.980011
Matrix protein 2Influenza A virus (A/Puerto Rico/8/1934(H1N1))IC50153.925044
Matrix protein 2Influenza A virus (A/udorn/1972(H3N2))IC50109.860055
Melatonin receptor type 1AHomo sapiens (human)Ki1.900011
Multidrug and toxin extrusion protein 1Homo sapiens (human)IC5037.800011
Multidrug resistance-associated protein 4Homo sapiens (human)IC50133.000013
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 2Homo sapiens (human)IC5014.500022
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3Homo sapiens (human)IC5014.500022
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4Homo sapiens (human)IC5014.500022
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1Homo sapiens (human)IC5014.500022
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrialHomo sapiens (human)IC5014.500022
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11Homo sapiens (human)IC5014.500022
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12Homo sapiens (human)IC5014.500022
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13Homo sapiens (human)IC5014.500022
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 Homo sapiens (human)IC5014.500022
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3Homo sapiens (human)IC5014.500022
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2Homo sapiens (human)IC5014.500022
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5Homo sapiens (human)IC5014.500022
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6Homo sapiens (human)IC5014.500022
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7Homo sapiens (human)IC5014.500022
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8Homo sapiens (human)IC5014.500022
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrialHomo sapiens (human)IC5014.500022
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1Homo sapiens (human)IC5014.500022
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10Homo sapiens (human)IC5014.500022
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrialHomo sapiens (human)IC5014.500022
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrialHomo sapiens (human)IC5014.500022
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3Homo sapiens (human)IC5014.500022
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 Homo sapiens (human)IC5014.500022
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrialHomo sapiens (human)IC5014.500022
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6Homo sapiens (human)IC5014.500022
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7Homo sapiens (human)IC5014.500022
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrialHomo sapiens (human)IC5014.500022
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9Homo sapiens (human)IC5014.500022
NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrialHomo sapiens (human)IC5014.500022
NADH dehydrogenase [ubiquinone] 1 subunit C2Homo sapiens (human)IC5014.500022
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrialHomo sapiens (human)IC5014.500022
NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrialHomo sapiens (human)IC5014.500022
NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrialHomo sapiens (human)IC5014.500022
NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrialHomo sapiens (human)IC5014.500022
NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrialHomo sapiens (human)IC5014.500022
NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrialHomo sapiens (human)IC5014.500022
NADH dehydrogenase [ubiquinone] iron-sulfur protein 5Homo sapiens (human)IC5014.500022
NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrialHomo sapiens (human)IC5014.500022
NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrialHomo sapiens (human)IC5014.500022
NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrialHomo sapiens (human)IC5014.500022
NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrialHomo sapiens (human)IC5014.500022
NADH-ubiquinone oxidoreductase chain 1Homo sapiens (human)IC5014.500022
NADH-ubiquinone oxidoreductase chain 2Homo sapiens (human)IC5014.500022
NADH-ubiquinone oxidoreductase chain 3Homo sapiens (human)IC5014.500022
NADH-ubiquinone oxidoreductase chain 4Homo sapiens (human)IC5014.500022
NADH-ubiquinone oxidoreductase chain 4LHomo sapiens (human)IC5014.500022
NADH-ubiquinone oxidoreductase chain 5Homo sapiens (human)IC5014.500022
NADH-ubiquinone oxidoreductase chain 6Homo sapiens (human)IC5014.500022
Neuronal acetylcholine receptor subunit alpha-3Rattus norvegicus (Norway rat)IC506.000011
Neuronal acetylcholine receptor subunit alpha-6Rattus norvegicus (Norway rat)IC506.000011
Neuronal acetylcholine receptor subunit beta-4Rattus norvegicus (Norway rat)IC506.000011
Phenylethanolamine N-methyltransferaseBos taurus (cattle)Ki435.333323
polyadenylate-binding protein 1Homo sapiens (human)IC5055.490022
Polyunsaturated fatty acid lipoxygenase ALOX15Homo sapiens (human)IC5023.900011
Polyunsaturated fatty acid lipoxygenase ALOX15Oryctolagus cuniculus (rabbit)IC502.258011
Replicase polyprotein 1abBetacoronavirus England 1IC5010.000012
Replicase polyprotein 1abSevere acute respiratory syndrome coronavirus 2IC501.276713
Sodium-dependent dopamine transporter Homo sapiens (human)IC500.288411
Sodium-dependent dopamine transporter Homo sapiens (human)Ki0.109011
Sodium-dependent noradrenaline transporter Homo sapiens (human)IC500.631011
Sodium-dependent noradrenaline transporter Homo sapiens (human)Ki0.101011
Sodium-dependent serotonin transporterHomo sapiens (human)IC5016.595911
Sodium-dependent serotonin transporterHomo sapiens (human)Ki5.728011
Solute carrier family 15 member 1Homo sapiens (human)IC50141,200.000011
Solute carrier family 22 member 1Rattus norvegicus (Norway rat)IC50285.433333
Solute carrier family 22 member 1 Homo sapiens (human)IC5027.200011
Solute carrier family 22 member 2Homo sapiens (human)IC5023.000011
Solute carrier family 22 member 2Rattus norvegicus (Norway rat)IC50256.966733
SUMO-conjugating enzyme UBC9Homo sapiens (human)IC5012.420022
SUMO1 activating enzyme subunit 1Homo sapiens (human)IC5012.420022
TatHuman immunodeficiency virus 1IC508.835011
TyrosinaseHomo sapiens (human)IC508,400.000011
Tyrosine-protein kinase FynHomo sapiens (human)IC502.938512
Tyrosine-protein kinase LckHomo sapiens (human)IC505.262012
Ubiquitin-like modifier activating enzyme 2Homo sapiens (human)IC5012.420022
VifHuman immunodeficiency virus 1IC501.490011

Activation Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
5-hydroxytryptamine receptor 1ARattus norvegicus (Norway rat)Kd4.466812
5-hydroxytryptamine receptor 1BRattus norvegicus (Norway rat)Kd4.466812
5-hydroxytryptamine receptor 1DRattus norvegicus (Norway rat)Kd4.466812
5-hydroxytryptamine receptor 1FRattus norvegicus (Norway rat)Kd4.466812
5-hydroxytryptamine receptor 2ARattus norvegicus (Norway rat)Kd4.466812
5-hydroxytryptamine receptor 2BRattus norvegicus (Norway rat)Kd4.466812
5-hydroxytryptamine receptor 2CRattus norvegicus (Norway rat)Kd4.466812
5-hydroxytryptamine receptor 3ARattus norvegicus (Norway rat)Kd4.466812
5-hydroxytryptamine receptor 3BRattus norvegicus (Norway rat)Kd4.466812
5-hydroxytryptamine receptor 4 Rattus norvegicus (Norway rat)Kd4.466812
5-hydroxytryptamine receptor 5ARattus norvegicus (Norway rat)Kd4.466812
5-hydroxytryptamine receptor 5BRattus norvegicus (Norway rat)Kd4.466812
5-hydroxytryptamine receptor 6Rattus norvegicus (Norway rat)Kd4.466812
5-hydroxytryptamine receptor 7 Rattus norvegicus (Norway rat)Kd4.466812
alkaline phosphatase, germ cell type preproproteinHomo sapiens (human)EC5011.500011
alkaline phosphatase, intestinalHomo sapiens (human)EC507.175022
alkaline phosphatase, tissue-nonspecific isozyme isoform 1 preproproteinHomo sapiens (human)EC50100.000011
Matrix protein 2Influenza A virus (A/udorn/1972(H3N2))EC500.660022
Matrix protein 2Influenza A virus (A/Puerto Rico/8/1934(H1N1))Kd0.320011
Matrix protein 2Influenza A virus (A/udorn/1972(H3N2))Kd58.292544
POsterior SegregationCaenorhabditis elegansEC50693.725522
Sigma non-opioid intracellular receptor 1Rattus norvegicus (Norway rat)EC500.990011
Sodium-dependent dopamine transporterRattus norvegicus (Norway rat)EC500.025011
Sodium-dependent dopamine transporter Homo sapiens (human)EC500.990011
Sodium-dependent noradrenaline transporter Homo sapiens (human)EC500.161022
Sodium-dependent serotonin transporterHomo sapiens (human)EC500.140011
Sodium-dependent serotonin transporterRattus norvegicus (Norway rat)EC501.765011
Trace amine-associated receptor 1Homo sapiens (human)EC501.627045
Trace amine-associated receptor 1Macaca mulatta (Rhesus monkey)EC501.010011
Trace amine-associated receptor 1Mus musculus (house mouse)EC500.103955
Trace amine-associated receptor 1Rattus norvegicus (Norway rat)EC500.532866
Zinc finger protein mex-5Caenorhabditis elegansEC50675.056022

Other Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
Adenosine receptor A1Rattus norvegicus (Norway rat)KA11.400011
Adenosine receptor A2aRattus norvegicus (Norway rat)KA11.400012
aryl hydrocarbon receptor nuclear translocatorHomo sapiens (human)AC5013.310011
Carbonic anhydraseCandida albicans SC5314KA0.960011
Carbonic anhydraseMethanosarcina thermophilaKA39.000011
Carbonic anhydraseMethanothermobacter thermautotrophicus str. Delta HKa11.400011
Carbonic anhydraseSaccharomyces cerevisiae S288CKa90.000022
Carbonic anhydrase Cryptococcus neoformans var. grubiiKA43.300011
Carbonic anhydrase Nakaseomyces glabratus CBS 138Ka23.300011
Carbonic anhydrase 1Homo sapiens (human)KA3.10001111
Carbonic anhydrase 12Homo sapiens (human)KA1.670011
Carbonic anhydrase 13Mus musculus (house mouse)KA43.000011
Carbonic anhydrase 14Homo sapiens (human)KA12.100011
Carbonic anhydrase 15Mus musculus (house mouse)KA6.500011
Carbonic anhydrase 2Homo sapiens (human)KA11.40001313
Carbonic anhydrase 3Homo sapiens (human)KA13.500022
Carbonic anhydrase 4Homo sapiens (human)KA15.300022
Carbonic anhydrase 5A, mitochondrialHomo sapiens (human)KA0.036011
Carbonic anhydrase 5B, mitochondrialHomo sapiens (human)KA0.063011
Carbonic anhydrase 6Homo sapiens (human)Ka18.000022
Carbonic anhydrase 7Homo sapiens (human)KA58.300011
Carbonic anhydrase 9Homo sapiens (human)KA51.300011
Carbonic anhydrase-like protein, putativeTrypanosoma cruzi strain CL BrenerKA0.830011
Glutamate receptor ionotropic, NMDA 1 Rattus norvegicus (Norway rat)KA58.300011
Glutamate receptor ionotropic, NMDA 2A Rattus norvegicus (Norway rat)KA58.300011
Glutamate receptor ionotropic, NMDA 2BRattus norvegicus (Norway rat)KA58.300011
Glutamate receptor ionotropic, NMDA 2CRattus norvegicus (Norway rat)KA58.300011
Glutamate receptor ionotropic, NMDA 2DRattus norvegicus (Norway rat)KA58.300011
Glutamate receptor ionotropic, NMDA 3ARattus norvegicus (Norway rat)KA58.300011
Glutamate receptor ionotropic, NMDA 3BRattus norvegicus (Norway rat)KA58.300011
Monocarboxylate transporter 10Rattus norvegicus (Norway rat)Km6,430.000011
Plasma kallikreinHomo sapiens (human)KA0.063011
Polyphenol oxidase 2Agaricus bisporusKm860.000011
SLC16A10 proteinHomo sapiens (human)Km1,212.500011
Solute carrier family 22 member 1 Homo sapiens (human)Activity18.400011
Solute carrier family 22 member 2Homo sapiens (human)Km30.500012
transforming acidic coiled-coil-containing protein 3Homo sapiens (human)AC5013.310011
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