A drug used for its effects on dopamine receptors, on the life cycle of dopamine, or on the survival of dopaminergic neurons.
| Member | Definition | Class |
|---|
| amantadine | A member of the class of adamantanes that is used as an antiviral and antiparkinson drug. | amantadine |
| aurapten | A member of the class of coumarins that is umbelliferone in which the phenolic hydrogen has been replaced by a geranyl group. Ii is isolated from several edible fruits and vegetables and exhibits a variety of therapeutic properties. | auraptene |
| benserazide | A carbohydrazide that results from the formal condensation of the carboxy group of DL-serine with the primary amino group of 4-(hydrazinylmethyl)benzene-1,2,3-triol. An aromatic-L-amino-acid decarboxylase inhibitor (DOPA decarboxylase inhibitor) that does not enter the central nervous system, it is used as its hydrochloride salt as an adjunct to levodopa in the treatment of parkinsonism. By preventing the conversion of levodopa to dopamine in the periphery, it causes an increase in the amount of levodopa reaching the central nervous system and so reduces the required dose. Benserazide has no antiparkinson actions when given alone. | benserazide |
| benserazide hydrochloride | A hydrochloride that is the monohydrochloride salt of benserazide. An aromatic-L-amino-acid decarboxylase inhibitor (DOPA decarboxylase inhibitor) that does not enter the central nervous system, it is used as an adjunct to levodopa in the treatment of parkinsonism. By preventing the conversion of levodopa to dopamine in the periphery, it causes an increase in the amount of levodopa reaching the central nervous system and so reduces the required dose. Benserazide hydrochloride has no antiparkinson actions when given alone. | benserazide hydrochloride |
| carbidopa | 3-(3,4-Dihydroxyphenyl)propanoic acid in which the hydrogens alpha- to the carboxyl group are substituted by hydrazinyl and methyl groups (S-configuration). Carbidopa is a dopa decarboxylase inhibitor, so prevents conversion of levodopa to dopamine. It has no antiparkinson activity by itself, but is used (commonly as its hydrate) in the management of Parkinson's disease to reduce peripheral adverse effects of levodopa. | carbidopa (anhydrous) |
| carbidopa | The hydrate of 3-(3,4-dihydroxyphenyl)propanoic acid in which the hydrogens alpha- to the carboxyl group are substituted by hydrazinyl and methyl groups (S-configuration). Carbidopa is a dopa decarboxylase inhibitor, so prevents conversion of levodopa to dopamine. It has no antiparkinson activity by itself, but is used in the management of Parkinson's disease to reduce peripheral adverse effects of levodopa. | carbidopa |
| dextroamphetamine | A 1-phenylpropan-2-amine that has S configuration. | (S)-amphetamine |
| levodopa | An optically active form of dopa having L-configuration. Used to treat the stiffness, tremors, spasms, and poor muscle control of Parkinson's disease | L-dopa zwitterion; L-dopa |
| memantine | A primary aliphatic amine that is the 3,5-dimethyl derivative of 1-aminoadamantane. A low to moderate affinity uncompetitive (open-channel); NMDA receptor antagonist which binds preferentially to the NMDA receptor-operated cation channels. | memantine |
| memantine hydrochloride | A hydrochloride obtained by reaction of memantine with one equivalent of hydrochloric acid. A low to moderate affinity uncompetitive (open-channel); NMDA receptor antagonist which binds preferentially to the NMDA receptor-operated cation channels. | memantine hydrochloride |
| phentermine | | phentermine |
| selegiline hydrochloride, (r)-isomer | | selegiline hydrochloride |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| 15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1 | Homo sapiens (human) | Potency | 31.4972 | 1 | 5 |
| 15-lipoxygenase, partial | Homo sapiens (human) | Potency | 21.8959 | 1 | 2 |
| acetylcholinesterase | Homo sapiens (human) | Potency | 0.8709 | 1 | 1 |
| acid sphingomyelinase | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| aldehyde dehydrogenase 1 family, member A1 | Homo sapiens (human) | Potency | 25.5952 | 1 | 9 |
| alpha-galactosidase | Homo sapiens (human) | Potency | 14.1254 | 1 | 1 |
| apical membrane antigen 1, AMA1 | Plasmodium falciparum 3D7 | Potency | 10.3664 | 1 | 4 |
| AR protein | Homo sapiens (human) | Potency | 17.2879 | 9 | 11 |
| aryl hydrocarbon receptor | Homo sapiens (human) | Potency | 15.2854 | 2 | 2 |
| arylsulfatase A | Homo sapiens (human) | Potency | 20.6569 | 1 | 2 |
| ATP-dependent phosphofructokinase | Trypanosoma brucei brucei TREU927 | Potency | 9.1542 | 2 | 4 |
| atrial natriuretic peptide receptor 1 precursor | Homo sapiens (human) | Potency | 23.9341 | 1 | 1 |
| Bloom syndrome protein isoform 1 | Homo sapiens (human) | Potency | 1.3580 | 1 | 1 |
| bromodomain adjacent to zinc finger domain 2B | Homo sapiens (human) | Potency | 30.3504 | 1 | 2 |
| Chain A, 2-oxoglutarate Oxygenase | Homo sapiens (human) | Potency | 12.3440 | 1 | 8 |
| Chain A, ATP-DEPENDENT DNA HELICASE Q1 | Homo sapiens (human) | Potency | 12.5893 | 1 | 1 |
| Chain A, Beta-lactamase | Escherichia coli K-12 | Potency | 24.3616 | 1 | 2 |
| Chain A, HADH2 protein | Homo sapiens (human) | Potency | 13.5403 | 2 | 5 |
| Chain A, JmjC domain-containing histone demethylation protein 3A | Homo sapiens (human) | Potency | 48.3423 | 1 | 5 |
| Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE | Homo sapiens (human) | Potency | 17.5859 | 1 | 4 |
| Chain A, Putative fructose-1,6-bisphosphate aldolase | Giardia intestinalis | Potency | 12.6566 | 1 | 6 |
| Chain A, TYROSYL-DNA PHOSPHODIESTERASE | Homo sapiens (human) | Potency | 15.2006 | 1 | 6 |
| Chain B, HADH2 protein | Homo sapiens (human) | Potency | 13.5403 | 2 | 5 |
| chromobox protein homolog 1 | Homo sapiens (human) | Potency | 49.8115 | 2 | 8 |
| cytochrome P450 2C9, partial | Homo sapiens (human) | Potency | 25.4448 | 1 | 2 |
| cytochrome P450 2D6 | Homo sapiens (human) | Potency | 28.0962 | 1 | 3 |
| cytochrome P450 3A4 isoform 1 | Homo sapiens (human) | Potency | 39.8107 | 2 | 4 |
| cytochrome P450 family 3 subfamily A polypeptide 4 | Homo sapiens (human) | Potency | 30.1116 | 1 | 1 |
| cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a | Homo sapiens (human) | Potency | 14.1466 | 1 | 2 |
| D(1A) dopamine receptor | Sus scrofa (pig) | Potency | 23.2809 | 1 | 1 |
| DNA polymerase beta | Homo sapiens (human) | Potency | 40.4367 | 1 | 3 |
| DNA polymerase eta isoform 1 | Homo sapiens (human) | Potency | 42.7722 | 2 | 3 |
| DNA polymerase iota isoform a (long) | Homo sapiens (human) | Potency | 32.2572 | 2 | 6 |
| DNA polymerase kappa isoform 1 | Homo sapiens (human) | Potency | 10.5015 | 1 | 4 |
| dopamine D1 receptor | Homo sapiens (human) | Potency | 8.1995 | 1 | 1 |
| endonuclease IV | Escherichia coli | Potency | 27.9443 | 1 | 2 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 24.2902 | 2 | 2 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 10.5909 | 1 | 1 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 8.0364 | 1 | 10 |
| EWS/FLI fusion protein | Homo sapiens (human) | Potency | 24.1046 | 4 | 9 |
| flap endonuclease 1 | Homo sapiens (human) | Potency | 23.1083 | 3 | 5 |
| G | Vesicular stomatitis virus | Potency | 25.4448 | 1 | 2 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | Potency | 39.8107 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Potency | 39.8107 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Potency | 39.8107 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Potency | 39.8107 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Potency | 39.8107 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | Potency | 39.8107 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | Potency | 39.8107 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | Potency | 39.8107 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Potency | 39.8107 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | Potency | 39.8107 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | Potency | 39.8107 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | Potency | 39.8107 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | Potency | 39.8107 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | Potency | 39.8107 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | Potency | 39.8107 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | Potency | 39.8107 | 1 | 2 |
| geminin | Homo sapiens (human) | Potency | 10.8455 | 2 | 8 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 8.3713 | 2 | 5 |
| glp-1 receptor, partial | Homo sapiens (human) | Potency | 19.9526 | 1 | 1 |
| GLS protein | Homo sapiens (human) | Potency | 27.1884 | 2 | 6 |
| glucocerebrosidase | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 6.3735 | 1 | 2 |
| glucokinase regulatory protein | Homo sapiens (human) | Potency | 5.0119 | 1 | 1 |
| heat shock protein beta-1 | Homo sapiens (human) | Potency | 13.3322 | 1 | 1 |
| hexokinase-4 isoform 1 | Homo sapiens (human) | Potency | 5.0119 | 1 | 1 |
| Histamine H2 receptor | Cavia porcellus (domestic guinea pig) | Potency | 22.3872 | 1 | 2 |
| histone acetyltransferase KAT2A isoform 1 | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| Histone H2A.x | Cricetulus griseus (Chinese hamster) | Potency | 34.8267 | 1 | 1 |
| HLA class I histocompatibility antigen, B alpha chain | Homo sapiens (human) | Potency | 25.4448 | 1 | 2 |
| huntingtin isoform 2 | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
| hypothetical protein, conserved | Trypanosoma brucei | Potency | 14.1254 | 1 | 1 |
| hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | Homo sapiens (human) | Potency | 10.0000 | 2 | 2 |
| IDH1 | Homo sapiens (human) | Potency | 6.5131 | 1 | 1 |
| importin subunit beta-1 isoform 1 | Homo sapiens (human) | Potency | 56.2341 | 1 | 1 |
| Inositol hexakisphosphate kinase 1 | Homo sapiens (human) | Potency | 25.4448 | 1 | 4 |
| Inositol monophosphatase 1 | Rattus norvegicus (Norway rat) | Potency | 31.6228 | 1 | 1 |
| Interferon beta | Homo sapiens (human) | Potency | 25.4448 | 1 | 2 |
| lamin isoform A-delta10 | Homo sapiens (human) | Potency | 9.1456 | 1 | 5 |
| lethal(3)malignant brain tumor-like protein 1 isoform I | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| Luciferase | Photinus pyralis (common eastern firefly) | Potency | 26.4014 | 2 | 3 |
| lysosomal alpha-glucosidase preproprotein | Homo sapiens (human) | Potency | 3.1381 | 1 | 1 |
| M-phase phosphoprotein 8 | Homo sapiens (human) | Potency | 14.2642 | 1 | 5 |
| Microtubule-associated protein tau | Homo sapiens (human) | Potency | 13.7437 | 2 | 13 |
| mitogen-activated protein kinase 1 | Homo sapiens (human) | Potency | 16.6168 | 2 | 3 |
| muscarinic acetylcholine receptor M1 | Rattus norvegicus (Norway rat) | Potency | 0.0708 | 1 | 1 |
| neuropeptide S receptor isoform A | Homo sapiens (human) | Potency | 5.0119 | 1 | 2 |
| NFKB1 protein, partial | Homo sapiens (human) | Potency | 2.8184 | 2 | 2 |
| nonstructural protein 1 | Influenza A virus (A/WSN/1933(H1N1)) | Potency | 25.1189 | 1 | 1 |
| nuclear factor erythroid 2-related factor 2 isoform 2 | Homo sapiens (human) | Potency | 23.1093 | 1 | 1 |
| nuclear receptor ROR-gamma isoform 1 | Mus musculus (house mouse) | Potency | 7.0795 | 1 | 1 |
| parathyroid hormone/parathyroid hormone-related peptide receptor precursor | Homo sapiens (human) | Potency | 79.4328 | 1 | 1 |
| Parkin | Homo sapiens (human) | Potency | 44.6684 | 1 | 1 |
| peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Homo sapiens (human) | Potency | 63.5290 | 2 | 2 |
| peripheral myelin protein 22 | Rattus norvegicus (Norway rat) | Potency | 14.6308 | 2 | 5 |
| peripheral myelin protein 22 isoform 1 | Homo sapiens (human) | Potency | 84.9214 | 1 | 2 |
| phosphoglycerate kinase | Trypanosoma brucei brucei TREU927 | Potency | 12.1739 | 3 | 3 |
| phosphopantetheinyl transferase | Bacillus subtilis | Potency | 46.7192 | 3 | 9 |
| PINK1 | Homo sapiens (human) | Potency | 44.6684 | 1 | 1 |
| Polyunsaturated fatty acid lipoxygenase ALOX15B | Homo sapiens (human) | Potency | 22.3872 | 1 | 1 |
| pregnane X nuclear receptor | Homo sapiens (human) | Potency | 11.8832 | 1 | 1 |
| progesterone receptor | Homo sapiens (human) | Potency | 16.7855 | 1 | 1 |
| putative alpha-glucosidase | Oryza sativa Japonica Group (Japanese rice) | Potency | 28.1838 | 1 | 2 |
| pyruvate kinase | Leishmania mexicana mexicana | Potency | 25.1189 | 2 | 2 |
| RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 30.0474 | 1 | 2 |
| regulator of G-protein signaling 4 | Homo sapiens (human) | Potency | 16.4378 | 1 | 4 |
| retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 22.3663 | 3 | 3 |
| serine-protein kinase ATM isoform a | Homo sapiens (human) | Potency | 22.3872 | 1 | 1 |
| serine/threonine-protein kinase mTOR isoform 1 | Homo sapiens (human) | Potency | 18.6546 | 2 | 3 |
| serine/threonine-protein kinase PLK1 | Homo sapiens (human) | Potency | 6.7016 | 1 | 1 |
| signal transducer and activator of transcription 6, interleukin-4 induced | Homo sapiens (human) | Potency | 100.0000 | 1 | 1 |
| Smad3 | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
| snurportin-1 | Homo sapiens (human) | Potency | 56.2341 | 1 | 1 |
| Spike glycoprotein | Severe acute respiratory syndrome-related coronavirus | Potency | 0.6310 | 1 | 1 |
| survival motor neuron protein isoform d | Homo sapiens (human) | Potency | 1.1220 | 1 | 1 |
| TAR DNA-binding protein 43 | Homo sapiens (human) | Potency | 10.0000 | 1 | 1 |
| TDP1 protein | Homo sapiens (human) | Potency | 17.7301 | 2 | 15 |
| thioredoxin glutathione reductase | Schistosoma mansoni | Potency | 0.3162 | 1 | 1 |
| thioredoxin reductase | Rattus norvegicus (Norway rat) | Potency | 12.9648 | 3 | 14 |
| Thrombopoietin | Homo sapiens (human) | Potency | 25.1189 | 2 | 2 |
| thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 31.6704 | 2 | 4 |
| thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 6.3096 | 2 | 2 |
| transcriptional regulator ERG isoform 3 | Homo sapiens (human) | Potency | 50.1187 | 1 | 1 |
| transient receptor potential cation channel subfamily V member 1 | Homo sapiens (human) | Potency | 19.9526 | 1 | 1 |
| ubiquitin carboxyl-terminal hydrolase 2 isoform a | Homo sapiens (human) | Potency | 20.7491 | 1 | 1 |
| USP1 protein, partial | Homo sapiens (human) | Potency | 61.7233 | 2 | 3 |
| vitamin D (1,25- dihydroxyvitamin D3) receptor | Homo sapiens (human) | Potency | 0.1962 | 2 | 2 |
| vitamin D3 receptor isoform VDRA | Homo sapiens (human) | Potency | 71.0052 | 1 | 4 |
| WRN | Homo sapiens (human) | Potency | 5.4979 | 2 | 2 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| 5-hydroxytryptamine receptor 7 | Cavia porcellus (domestic guinea pig) | IC50 | 27.2000 | 1 | 2 |
| Acetylcholinesterase | Electrophorus electricus (electric eel) | IC50 | 10.0000 | 1 | 1 |
| Acetylcholinesterase | Homo sapiens (human) | IC50 | 0.0049 | 1 | 1 |
| Acyl carrier protein, mitochondrial | Homo sapiens (human) | IC50 | 14.5000 | 2 | 2 |
| Amine oxidase [flavin-containing] A | Homo sapiens (human) | IC50 | 1.7000 | 1 | 1 |
| Amine oxidase [flavin-containing] A | Mus musculus (house mouse) | IC50 | 0.0000 | 1 | 1 |
| Amine oxidase [flavin-containing] A | Homo sapiens (human) | Ki | 14.4000 | 1 | 1 |
| Amine oxidase [flavin-containing] A | Rattus norvegicus (Norway rat) | IC50 | 0.9440 | 1 | 1 |
| Amine oxidase [flavin-containing] B | Homo sapiens (human) | IC50 | 0.0067 | 2 | 2 |
| Amine oxidase [flavin-containing] B | Mus musculus (house mouse) | IC50 | 0.3000 | 2 | 2 |
| Amine oxidase [flavin-containing] B | Rattus norvegicus (Norway rat) | IC50 | 0.0068 | 2 | 2 |
| Amine oxidase [flavin-containing] B | Bos taurus (cattle) | Ki | 300.0000 | 1 | 1 |
| Amine oxidase [flavin-containing] B | Homo sapiens (human) | Ki | 280.0000 | 1 | 1 |
| Amine oxidase [flavin-containing] B | Rattus norvegicus (Norway rat) | Ki | 370.0000 | 2 | 2 |
| ATP-binding cassette sub-family C member 3 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 3 |
| Beta-secretase 1 | Homo sapiens (human) | IC50 | 345.1000 | 1 | 1 |
| Bile salt export pump | Homo sapiens (human) | IC50 | 378.6571 | 3 | 7 |
| Canalicular multispecific organic anion transporter 1 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 3 |
| Cholinesterase | Equus caballus (horse) | IC50 | 10.0000 | 1 | 1 |
| Complex I intermediate-associated protein 30, mitochondrial | Homo sapiens (human) | IC50 | 14.5000 | 2 | 2 |
| Cytochrome c oxidase subunit NDUFA4 | Homo sapiens (human) | IC50 | 14.5000 | 2 | 2 |
| Cytochrome P450 2C9 | Homo sapiens (human) | IC50 | 1.3761 | 1 | 1 |
| DNA dC->dU-editing enzyme APOBEC-3G isoform 1 | Homo sapiens (human) | IC50 | 1.4900 | 1 | 1 |
| Epidermal growth factor receptor | Homo sapiens (human) | IC50 | 451.4400 | 2 | 2 |
| estrogen receptor beta isoform 1 | Homo sapiens (human) | IC50 | 3.0540 | 1 | 1 |
| Genome polyprotein | Coxsackievirus B3 (strain Nancy) | IC50 | 2.4000 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 1 | Homo sapiens (human) | IC50 | 4.1374 | 11 | 11 |
| Glutamate receptor ionotropic, NMDA 1 | Homo sapiens (human) | Ki | 3.1450 | 3 | 4 |
| Glutamate receptor ionotropic, NMDA 1 | Rattus norvegicus (Norway rat) | IC50 | 70.0724 | 13 | 19 |
| Glutamate receptor ionotropic, NMDA 1 | Rattus norvegicus (Norway rat) | Ki | 0.7000 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 2A | Homo sapiens (human) | IC50 | 3.4674 | 7 | 7 |
| Glutamate receptor ionotropic, NMDA 2A | Homo sapiens (human) | Ki | 3.8600 | 2 | 3 |
| Glutamate receptor ionotropic, NMDA 2A | Rattus norvegicus (Norway rat) | IC50 | 73.8487 | 12 | 18 |
| Glutamate receptor ionotropic, NMDA 2A | Rattus norvegicus (Norway rat) | Ki | 0.7000 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 2B | Homo sapiens (human) | IC50 | 5.3100 | 4 | 4 |
| Glutamate receptor ionotropic, NMDA 2B | Rattus norvegicus (Norway rat) | IC50 | 80.5624 | 11 | 16 |
| Glutamate receptor ionotropic, NMDA 2B | Homo sapiens (human) | Ki | 3.1450 | 3 | 4 |
| Glutamate receptor ionotropic, NMDA 2B | Rattus norvegicus (Norway rat) | Ki | 0.7000 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 2C | Rattus norvegicus (Norway rat) | IC50 | 85.7933 | 10 | 15 |
| Glutamate receptor ionotropic, NMDA 2C | Homo sapiens (human) | Ki | 3.8600 | 2 | 3 |
| Glutamate receptor ionotropic, NMDA 2C | Rattus norvegicus (Norway rat) | Ki | 0.7000 | 1 | 2 |
| Glutamate receptor ionotropic, NMDA 2D | Rattus norvegicus (Norway rat) | IC50 | 85.7933 | 10 | 15 |
| Glutamate receptor ionotropic, NMDA 2D | Homo sapiens (human) | Ki | 3.8600 | 2 | 3 |
| Glutamate receptor ionotropic, NMDA 2D | Rattus norvegicus (Norway rat) | Ki | 0.7000 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 3A | Rattus norvegicus (Norway rat) | IC50 | 85.7933 | 10 | 15 |
| Glutamate receptor ionotropic, NMDA 3A | Homo sapiens (human) | Ki | 3.8600 | 2 | 3 |
| Glutamate receptor ionotropic, NMDA 3A | Rattus norvegicus (Norway rat) | Ki | 0.7000 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 3B | Rattus norvegicus (Norway rat) | IC50 | 85.7933 | 10 | 15 |
| Glutamate receptor ionotropic, NMDA 3B | Homo sapiens (human) | Ki | 3.8600 | 2 | 3 |
| Glutamate receptor ionotropic, NMDA 3B | Rattus norvegicus (Norway rat) | Ki | 0.7000 | 1 | 1 |
| Hexokinase-2 | Homo sapiens (human) | IC50 | 5.5200 | 1 | 1 |
| integrase, partial | Human immunodeficiency virus 1 | IC50 | 0.5939 | 2 | 2 |
| intestinal alkaline phosphatase precursor | Mus musculus (house mouse) | IC50 | 50.9000 | 1 | 1 |
| Large neutral amino acids transporter small subunit 1 | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| lens epithelium-derived growth factor p75 | Homo sapiens (human) | IC50 | 0.5939 | 2 | 2 |
| Lysine-specific demethylase 4E | Homo sapiens (human) | Ki | 1.9800 | 1 | 1 |
| Matrix protein 2 | Influenza A virus (A/Puerto Rico/8/1934(H1N1)) | IC50 | 153.9250 | 4 | 4 |
| Matrix protein 2 | Influenza A virus (A/udorn/1972(H3N2)) | IC50 | 109.8600 | 5 | 5 |
| Melatonin receptor type 1A | Homo sapiens (human) | Ki | 1.9000 | 1 | 1 |
| Multidrug and toxin extrusion protein 1 | Homo sapiens (human) | IC50 | 37.8000 | 1 | 1 |
| Multidrug resistance-associated protein 4 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 3 |
| NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 2 | Homo sapiens (human) | IC50 | 14.5000 | 2 | 2 |
| NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3 | Homo sapiens (human) | IC50 | 14.5000 | 2 | 2 |
| NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4 | Homo sapiens (human) | IC50 | 14.5000 | 2 | 2 |
| NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 | Homo sapiens (human) | IC50 | 14.5000 | 2 | 2 |
| NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial | Homo sapiens (human) | IC50 | 14.5000 | 2 | 2 |
| NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 | Homo sapiens (human) | IC50 | 14.5000 | 2 | 2 |
| NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 | Homo sapiens (human) | IC50 | 14.5000 | 2 | 2 |
| NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 | Homo sapiens (human) | IC50 | 14.5000 | 2 | 2 |
| NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 | Homo sapiens (human) | IC50 | 14.5000 | 2 | 2 |
| NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 | Homo sapiens (human) | IC50 | 14.5000 | 2 | 2 |
| NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 | Homo sapiens (human) | IC50 | 14.5000 | 2 | 2 |
| NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 | Homo sapiens (human) | IC50 | 14.5000 | 2 | 2 |
| NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 | Homo sapiens (human) | IC50 | 14.5000 | 2 | 2 |
| NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 | Homo sapiens (human) | IC50 | 14.5000 | 2 | 2 |
| NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 | Homo sapiens (human) | IC50 | 14.5000 | 2 | 2 |
| NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial | Homo sapiens (human) | IC50 | 14.5000 | 2 | 2 |
| NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 | Homo sapiens (human) | IC50 | 14.5000 | 2 | 2 |
| NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 | Homo sapiens (human) | IC50 | 14.5000 | 2 | 2 |
| NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial | Homo sapiens (human) | IC50 | 14.5000 | 2 | 2 |
| NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial | Homo sapiens (human) | IC50 | 14.5000 | 2 | 2 |
| NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 | Homo sapiens (human) | IC50 | 14.5000 | 2 | 2 |
| NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 | Homo sapiens (human) | IC50 | 14.5000 | 2 | 2 |
| NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial | Homo sapiens (human) | IC50 | 14.5000 | 2 | 2 |
| NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 | Homo sapiens (human) | IC50 | 14.5000 | 2 | 2 |
| NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 | Homo sapiens (human) | IC50 | 14.5000 | 2 | 2 |
| NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial | Homo sapiens (human) | IC50 | 14.5000 | 2 | 2 |
| NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 | Homo sapiens (human) | IC50 | 14.5000 | 2 | 2 |
| NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial | Homo sapiens (human) | IC50 | 14.5000 | 2 | 2 |
| NADH dehydrogenase [ubiquinone] 1 subunit C2 | Homo sapiens (human) | IC50 | 14.5000 | 2 | 2 |
| NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial | Homo sapiens (human) | IC50 | 14.5000 | 2 | 2 |
| NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial | Homo sapiens (human) | IC50 | 14.5000 | 2 | 2 |
| NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial | Homo sapiens (human) | IC50 | 14.5000 | 2 | 2 |
| NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial | Homo sapiens (human) | IC50 | 14.5000 | 2 | 2 |
| NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial | Homo sapiens (human) | IC50 | 14.5000 | 2 | 2 |
| NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial | Homo sapiens (human) | IC50 | 14.5000 | 2 | 2 |
| NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 | Homo sapiens (human) | IC50 | 14.5000 | 2 | 2 |
| NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial | Homo sapiens (human) | IC50 | 14.5000 | 2 | 2 |
| NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial | Homo sapiens (human) | IC50 | 14.5000 | 2 | 2 |
| NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial | Homo sapiens (human) | IC50 | 14.5000 | 2 | 2 |
| NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial | Homo sapiens (human) | IC50 | 14.5000 | 2 | 2 |
| NADH-ubiquinone oxidoreductase chain 1 | Homo sapiens (human) | IC50 | 14.5000 | 2 | 2 |
| NADH-ubiquinone oxidoreductase chain 2 | Homo sapiens (human) | IC50 | 14.5000 | 2 | 2 |
| NADH-ubiquinone oxidoreductase chain 3 | Homo sapiens (human) | IC50 | 14.5000 | 2 | 2 |
| NADH-ubiquinone oxidoreductase chain 4 | Homo sapiens (human) | IC50 | 14.5000 | 2 | 2 |
| NADH-ubiquinone oxidoreductase chain 4L | Homo sapiens (human) | IC50 | 14.5000 | 2 | 2 |
| NADH-ubiquinone oxidoreductase chain 5 | Homo sapiens (human) | IC50 | 14.5000 | 2 | 2 |
| NADH-ubiquinone oxidoreductase chain 6 | Homo sapiens (human) | IC50 | 14.5000 | 2 | 2 |
| Neuronal acetylcholine receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | IC50 | 6.0000 | 1 | 1 |
| Neuronal acetylcholine receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | IC50 | 6.0000 | 1 | 1 |
| Neuronal acetylcholine receptor subunit beta-4 | Rattus norvegicus (Norway rat) | IC50 | 6.0000 | 1 | 1 |
| Phenylethanolamine N-methyltransferase | Bos taurus (cattle) | Ki | 435.3333 | 2 | 3 |
| polyadenylate-binding protein 1 | Homo sapiens (human) | IC50 | 55.4900 | 2 | 2 |
| Polyunsaturated fatty acid lipoxygenase ALOX15 | Homo sapiens (human) | IC50 | 23.9000 | 1 | 1 |
| Polyunsaturated fatty acid lipoxygenase ALOX15 | Oryctolagus cuniculus (rabbit) | IC50 | 2.2580 | 1 | 1 |
| Replicase polyprotein 1ab | Betacoronavirus England 1 | IC50 | 10.0000 | 1 | 2 |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome coronavirus 2 | IC50 | 1.2767 | 1 | 3 |
| Sodium-dependent dopamine transporter | Homo sapiens (human) | IC50 | 0.2884 | 1 | 1 |
| Sodium-dependent dopamine transporter | Homo sapiens (human) | Ki | 0.1090 | 1 | 1 |
| Sodium-dependent noradrenaline transporter | Homo sapiens (human) | IC50 | 0.6310 | 1 | 1 |
| Sodium-dependent noradrenaline transporter | Homo sapiens (human) | Ki | 0.1010 | 1 | 1 |
| Sodium-dependent serotonin transporter | Homo sapiens (human) | IC50 | 16.5959 | 1 | 1 |
| Sodium-dependent serotonin transporter | Homo sapiens (human) | Ki | 5.7280 | 1 | 1 |
| Solute carrier family 15 member 1 | Homo sapiens (human) | IC50 | 141,200.0000 | 1 | 1 |
| Solute carrier family 22 member 1 | Rattus norvegicus (Norway rat) | IC50 | 285.4333 | 3 | 3 |
| Solute carrier family 22 member 1 | Homo sapiens (human) | IC50 | 27.2000 | 1 | 1 |
| Solute carrier family 22 member 2 | Homo sapiens (human) | IC50 | 23.0000 | 1 | 1 |
| Solute carrier family 22 member 2 | Rattus norvegicus (Norway rat) | IC50 | 256.9667 | 3 | 3 |
| SUMO-conjugating enzyme UBC9 | Homo sapiens (human) | IC50 | 12.4200 | 2 | 2 |
| SUMO1 activating enzyme subunit 1 | Homo sapiens (human) | IC50 | 12.4200 | 2 | 2 |
| Tat | Human immunodeficiency virus 1 | IC50 | 8.8350 | 1 | 1 |
| Tyrosinase | Homo sapiens (human) | IC50 | 8,400.0000 | 1 | 1 |
| Tyrosine-protein kinase Fyn | Homo sapiens (human) | IC50 | 2.9385 | 1 | 2 |
| Tyrosine-protein kinase Lck | Homo sapiens (human) | IC50 | 5.2620 | 1 | 2 |
| Ubiquitin-like modifier activating enzyme 2 | Homo sapiens (human) | IC50 | 12.4200 | 2 | 2 |
| Vif | Human immunodeficiency virus 1 | IC50 | 1.4900 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| Adenosine receptor A1 | Rattus norvegicus (Norway rat) | KA | 11.4000 | 1 | 1 |
| Adenosine receptor A2a | Rattus norvegicus (Norway rat) | KA | 11.4000 | 1 | 2 |
| aryl hydrocarbon receptor nuclear translocator | Homo sapiens (human) | AC50 | 13.3100 | 1 | 1 |
| Carbonic anhydrase | Candida albicans SC5314 | KA | 0.9600 | 1 | 1 |
| Carbonic anhydrase | Methanosarcina thermophila | KA | 39.0000 | 1 | 1 |
| Carbonic anhydrase | Methanothermobacter thermautotrophicus str. Delta H | Ka | 11.4000 | 1 | 1 |
| Carbonic anhydrase | Saccharomyces cerevisiae S288C | Ka | 90.0000 | 2 | 2 |
| Carbonic anhydrase | Cryptococcus neoformans var. grubii | KA | 43.3000 | 1 | 1 |
| Carbonic anhydrase | Nakaseomyces glabratus CBS 138 | Ka | 23.3000 | 1 | 1 |
| Carbonic anhydrase 1 | Homo sapiens (human) | KA | 3.1000 | 11 | 11 |
| Carbonic anhydrase 12 | Homo sapiens (human) | KA | 1.6700 | 1 | 1 |
| Carbonic anhydrase 13 | Mus musculus (house mouse) | KA | 43.0000 | 1 | 1 |
| Carbonic anhydrase 14 | Homo sapiens (human) | KA | 12.1000 | 1 | 1 |
| Carbonic anhydrase 15 | Mus musculus (house mouse) | KA | 6.5000 | 1 | 1 |
| Carbonic anhydrase 2 | Homo sapiens (human) | KA | 11.4000 | 13 | 13 |
| Carbonic anhydrase 3 | Homo sapiens (human) | KA | 13.5000 | 2 | 2 |
| Carbonic anhydrase 4 | Homo sapiens (human) | KA | 15.3000 | 2 | 2 |
| Carbonic anhydrase 5A, mitochondrial | Homo sapiens (human) | KA | 0.0360 | 1 | 1 |
| Carbonic anhydrase 5B, mitochondrial | Homo sapiens (human) | KA | 0.0630 | 1 | 1 |
| Carbonic anhydrase 6 | Homo sapiens (human) | Ka | 18.0000 | 2 | 2 |
| Carbonic anhydrase 7 | Homo sapiens (human) | KA | 58.3000 | 1 | 1 |
| Carbonic anhydrase 9 | Homo sapiens (human) | KA | 51.3000 | 1 | 1 |
| Carbonic anhydrase-like protein, putative | Trypanosoma cruzi strain CL Brener | KA | 0.8300 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 1 | Rattus norvegicus (Norway rat) | KA | 58.3000 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 2A | Rattus norvegicus (Norway rat) | KA | 58.3000 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 2B | Rattus norvegicus (Norway rat) | KA | 58.3000 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 2C | Rattus norvegicus (Norway rat) | KA | 58.3000 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 2D | Rattus norvegicus (Norway rat) | KA | 58.3000 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 3A | Rattus norvegicus (Norway rat) | KA | 58.3000 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 3B | Rattus norvegicus (Norway rat) | KA | 58.3000 | 1 | 1 |
| Monocarboxylate transporter 10 | Rattus norvegicus (Norway rat) | Km | 6,430.0000 | 1 | 1 |
| Plasma kallikrein | Homo sapiens (human) | KA | 0.0630 | 1 | 1 |
| Polyphenol oxidase 2 | Agaricus bisporus | Km | 860.0000 | 1 | 1 |
| SLC16A10 protein | Homo sapiens (human) | Km | 1,212.5000 | 1 | 1 |
| Solute carrier family 22 member 1 | Homo sapiens (human) | Activity | 18.4000 | 1 | 1 |
| Solute carrier family 22 member 2 | Homo sapiens (human) | Km | 30.5000 | 1 | 2 |
| transforming acidic coiled-coil-containing protein 3 | Homo sapiens (human) | AC50 | 13.3100 | 1 | 1 |