Porphyria Cutanea Tarda

An autosomal dominant or acquired porphyria due to a deficiency of UROPORPHYRINOGEN DECARBOXYLASE in the LIVER. It is characterized by photosensitivity and cutaneous lesions with little or no neurologic symptoms. Type I is the acquired form and is strongly associated with liver diseases and hepatic toxicities caused by alcohol or estrogenic steroids. Type II is the familial form.

Synonym
Porphyria Cutanea Tarda

Excerpt	Reference
"Porphyria cutanea tarda is a disorder of porphyrin metabolism, of which familial and sporadic forms have been described."	( Cleton, MI; de Bruijn, WC; Marx, JJ; Rademakers, LH; Siersema, PD; ten Kate, FJ; Wilson, JH, 1995)
"Porphyria cutanea tarda is a disorder of heme biosynthesis resulting from a defect or deficiency in the enzyme uroporphyrinogen decarboxylase."	( Demento, FJ; Fishbane, S; Frei, GL; Maesaka, JK; Ruggian, JC, 1996)
"Porphyria cutanea tarda is characterized by severe connective tissue damage in sun-exposed skin."	( Bolsen, K; Goerz, G; Herrmann, G; Prenzel, K; Scharffetter-Kochanek, K; Wlaschek, M, 1996)
"Human sporadic porphyria cutanea tarda is usually precipitated by alcohol, oestrogens, hepatitis viruses, HIV or haemodialysis."	( Akhtar, RA; Smith, AG, 1998)
"Diagnosis of porphyria cutanea tarda is usually fairly straightforward because of the characteristic clinical findings."	( Rich, MW, 1999)
"Porphyria cutanea tarda is a liver disease characterized by excess production of uroporphyrin."	( Bement, WJ; Dalton, TP; Gonzalez, FJ; Gorman, N; Nebert, DW; Sinclair, JF; Sinclair, PR; Szakacs, J; Walton, HS, 2000)
"Porphyria cutanea tarda is treated with phlebotomies in the absence of renal failure."	( Casanova, JM; Craver, L; Fernández, E; Marco, MP; Martín, M; Muray, S, 2002)
"Porphyria cutanea tarda is associated with hepatic iron overload and responds to iron-reduction therapy."	( Bonkovsky, HL; Lambrecht, RW; Shan, Y, 2003)
"Porphyria cutanea tarda is associated with hepatic iron overload and responds to iron-reduction therapy."	( Alla, V; Bonkovsky, HL, 2005)
"Porphyria cutanea tarda is a liver disease characterized by elevated hepatic iron and excessive production of uroporphyrin (URO)."	( Balestra, D; Gorman, N; Jacobs, JM; Jacobs, NJ; Sinclair, JF; Sinclair, PR; Szakacs, JG; Trask, HS; Zaharia, A, 2007)
"Porphyria cutanea tarda is the most common type of porphyria and results from low levels of the enzyme responsible for the fifth step in heme production."	( Williams, DS, 2007)
"Porphyria cutanea tarda is a disease of disordered accumulation of heme, which is needed for biosynthesis of hepatic cytochromes."	( Hoffman, CJ; Ray, SC, 2008)
"Pseudoporphyria cutanea tarda is a well described bullous skin disorder which resembles porphyria cutanea tarda."	( Bygum, A; Velander, MJ; Þorsteinsdóttir, S, 2015)

Excerpt	Reference
"Porphyria cutanea tarda has been described in adult hemodialysis patients."	( Demento, FJ; Fishbane, S; Frei, GL; Maesaka, JK; Ruggian, JC, 1996)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	23 (7.30)	23.3326
1990's	96 (30.48)	12.5806
2000's	119 (37.78)	18.1394
2010's	72 (22.86)	28.8240
2020's	5 (1.59)	9.53

Drug	Relationship Strength	Studies	Trials
gamma-aminobutyric acid	low	2	0
aminolevulinic acid	low	9	0
5-hydroxytryptophan	low	1	0
acetic acid	low	1	0
acetone	low	1	0
adenine	low	1	0
quinacrine	low	1	0
chlorine	low	1	0
coproporphyrinogen iii	low	1	0
salicylic acid	low	2	0
glycerol	low	1	0
methanol	low	1	0
niacinamide	low	1	0
niacin	low	1	0
porphobilinogen	low	6	0
pyridoxine	low	1	0
uroporphyrinogen iii	low	4	0
phenytoin	low	3	0
anastrozole	low	2	0
aspirin	low	1	0
busulfan	low	2	0
caffeine	low	1	0
carbamazepine	low	3	0
carisoprodol	low	1	0
chlorambucil	low	1	0
chloroquine	medium	29	2
chlorpromazine	low	1	0
cimetidine	low	2	0
ciprofloxacin	low	2	0
clonazepam	low	1	0
deferiprone	low	1	0
deferoxamine	low	8	0
dimercaprol	low	1	0
ether	low	1	0
fluconazole	low	1	0
fluorouracil	low	1	0
flutamide	low	1	0
furosemide	low	2	0
gabapentin	low	2	0
hydroxyurea	low	1	0
khellin	low	1	0
lamotrigine	low	1	0
meperidine	low	1	0
nabumetone	low	2	0
piracetam	low	1	0
propofol	low	1	0
pyrimethamine	low	1	0
prednisolone	low	1	0
prednisone	low	1	0
lysine	low	1	0
ethinyl estradiol	low	1	0
uridine monophosphate	low	4	0
tyrosine	low	2	0
leucine	low	1	0
norethindrone	low	1	0
asparagine	low	1	0
histidine	low	1	0
mestranol	low	1	0
tryptophan	low	1	0
arginine	low	2	0
acetonitrile	low	1	0
trichloroethylene	low	1	0
quinoxalines	low	2	0
cyclohexane	low	1	0
hexachlorobenzene	low	11	0
dydrogesterone	low	1	0
pyrazines	low	1	0
malondialdehyde	low	1	0
acetylcysteine	low	3	0
glycyrrhizic acid	low	2	0
d-alpha tocopherol	medium	4	2
pregnenolone carbonitrile	low	1	0
stavudine	low	1	0
manganese	low	1	0
tiletamine hydrochloride	low	1	0
urobilinogen	low	1	0
cephalexin	low	1	0
2,4',5-trichlorobiphenyl	low	1	0
carbimazole	low	1	0
phenyl acetate	low	3	0
transferrin	low	16	0
oxcarbazepine	low	1	0
zidovudine	low	3	0
ribavirin	low	8	0
chlorodiphenyl (54% chlorine)	low	2	0
atracurium	low	1	0
fomesafen	low	2	0
lovastatin	low	1	0
simvastatin	low	1	0
pravastatin	low	2	0
imiquimod	low	1	0
lamivudine	low	2	0
3,4,5,3',4'-pentachlorobiphenyl	low	2	0
chloroquine diphosphate	low	3	0
triazoles	medium	4	1
coproporphyrin i	low	2	0
4-aminoquinoline	low	2	0
voriconazole	low	1	0
uroporphyrin iii	low	2	0
uroporphyrin i	low	4	0
zinc coproporphyrin iii	low	4	0
nitisinone	low	1	0
imatinib mesylate	low	5	0
methotrexate	low	2	0
proline	low	2	0
naproxen	low	4	0
olmesartan	low	1	0
ferric ferricyanide	low	1	0
pentacarboxylic porphyrin	low	3	0
isocoproporphyrin	low	1	0
organophosphonates	low	1	0
troleandomycin	low	1	0
benzofurans	low	1	0
trimethoprim, sulfamethoxazole drug combination	low	1	0
bortezomib	low	1	0
ritonavir	low	1	0
fibrin	low	1	0
retinol	medium	2	1
lycopene	low	1	0
diethylstilbestrol	low	2	0
arsphenamine	low	1	0
tenofovir	low	1	0
riboflavin	low	1	0
ammonium acetate	low	1	0
tamoxifen	low	4	0
alpha-carotene	low	1	0
bilirubin	low	2	0
beta carotene	low	2	0
zeaxanthin	low	1	0
cryptoxanthins	low	1	0
lutein	low	1	0
levetiracetam	low	1	0
lead	low	1	0
barium	low	1	0
aluminum	low	2	0
indinavir sulfate	low	2	0
cysteine	low	1	0
nitrofurantoin	low	1	0
losartan potassium	low	10	0
nad	low	2	0
glycoprotein e2, hepatitis c virus	low	1	0
chlorophyll a	low	2	0
sofosbuvir	low	5	0
heme	low	22	0
ascorbic acid	low	4	0
tetracycline	low	1	0
tipranavir	low	1	0
transforming growth factor beta	low	1	0
ledipasvir	low	1	0
epoetin alfa	low	1	0
vitamin b 12	low	1	0
cyclosporine	low	1	0
levoleucovorin	low	1	0
deoxyguanosine	low	1	0
folic acid	low	2	0
rifampin	low	1	0
olanzapine	low	1	0
8-hydroxy-2'-deoxyguanosine	low	1	0
heme arginate	low	2	0
eye	low	2	0

Protein Targets (1,342)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Cytochrome P450 1A1	0	0	1	1
Aryl hydrocarbon receptor	0	0	1	1
Cytochrome P450 1B1	0	3	0	3
Neutrophil cytosol factor 1	0	1	1	2
Acetylcholinesterase	0	1	0	1
Chain A, Avidin	0	0	2	2
Chain A, Avidin	0	0	2	2
Chain B, Avidin	0	0	2	2
estrogen nuclear receptor alpha	67	0	0	67
Free fatty acid receptor 3	0	0	1	1
Free fatty acid receptor 2	0	1	1	2
Tyrosine-protein kinase Lck	0	1	1	2
Tyrosine-protein kinase Fyn	0	3	1	4
Fibrinogen C domain-containing protein 1	0	1	0	1
TDP1 protein	54	0	0	54
glucocorticoid receptor [Homo sapiens]	49	0	0	49
estrogen-related nuclear receptor alpha	45	0	0	45
thyroid hormone receptor beta isoform 2	44	0	0	44
lamin isoform A-delta10	42	0	0	42
pregnane X receptor	10	0	0	10
retinoic acid nuclear receptor alpha variant 1	44	0	0	44
nuclear factor erythroid 2-related factor 2 isoform 1	41	0	0	41
Chain A, JmjC domain-containing histone demethylation protein 3A	7	0	0	7
Chain A, 2-oxoglutarate Oxygenase	19	0	0	19
Chain A, ATP-DEPENDENT DNA HELICASE Q1	2	0	0	2
acetylcholinesterase	15	0	0	15
dopamine D1 receptor	3	0	0	3
15-lipoxygenase, partial	9	0	0	9
phosphopantetheinyl transferase	18	0	0	18
RAR-related orphan receptor gamma	32	0	0	32
USP1 protein, partial	25	0	0	25
NFKB1 protein, partial	7	0	0	7
Microtubule-associated protein tau	23	0	0	23
Thrombopoietin	5	0	0	5
AR protein	56	0	0	56
regulator of G-protein signaling 4	12	0	0	12
retinoid X nuclear receptor alpha	33	0	0	33
farnesoid X nuclear receptor	26	0	0	26
vitamin D (1,25- dihydroxyvitamin D3) receptor	23	0	0	23
arylsulfatase A	11	0	0	11
euchromatic histone-lysine N-methyltransferase 2	38	0	0	38
Bloom syndrome protein isoform 1	17	0	0	17
D(1A) dopamine receptor	8	0	0	8
thyroid hormone receptor beta isoform a	13	0	0	13
heat shock protein beta-1	13	0	0	13
flap endonuclease 1	12	0	0	12
geminin	50	0	0	50
peripheral myelin protein 22	21	0	0	21
survival motor neuron protein isoform d	17	0	0	17
muscarinic acetylcholine receptor M1	16	0	0	16
Histone deacetylase 3	0	4	0	4
Solute carrier family 22 member 6	0	10	0	11
Histone deacetylase 4	0	3	0	3
Guanine nucleotide-binding protein G	3	0	0	3
Histone deacetylase 1	0	5	0	5
Histone deacetylase 7	0	3	0	3
Histone deacetylase 2	0	5	0	5
Polyamine deacetylase HDAC10	0	3	0	3
Histone deacetylase 11	0	3	0	3
Ataxin-2	23	0	0	23
Histone deacetylase 8	0	4	0	4
Histone deacetylase 6	0	5	0	5
Histone deacetylase 9	0	3	0	3
Histone deacetylase 5	0	3	0	3
ATP-dependent phosphofructokinase	16	0	0	16
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	23	0	0	23
Chain A, MTA/SAH nucleosidase	0	1	0	1
Chain A, Ribosome-inactivating protein alpha-trichosanthin	0	0	1	1
Chain A, Ricin A chain	0	0	1	1
Chain A, Ribosome-inactivating protein 3	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
nuclear receptor subfamily 1, group I, member 3	35	0	0	35
cytochrome P450 family 3 subfamily A polypeptide 4	35	0	0	35
pregnane X nuclear receptor	37	0	0	37
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	31	0	0	31
nuclear factor erythroid 2-related factor 2 isoform 2	18	0	0	18
importin subunit beta-1 isoform 1	4	0	0	4
snurportin-1	4	0	0	4
tumor susceptibility gene 101 protein	2	0	0	2
GTP-binding nuclear protein Ran isoform 1	3	0	0	3
Voltage-dependent calcium channel gamma-2 subunit	20	0	0	20
Bile salt export pump	0	56	0	56
Cyclin-dependent kinase 1	0	1	0	1
Heat shock protein HSP 90-beta	0	1	0	1
Glutamate receptor 2	20	0	0	20
Xanthine dehydrogenase/oxidase	0	2	0	2
TAR DNA-binding protein 43	9	0	0	9
Protein mono-ADP-ribosyltransferase PARP15	0	2	0	2
Leucine-rich repeat serine/threonine-protein kinase 2	0	2	0	2
ATPase family AAA domain-containing protein 5	18	0	0	18
Chain A, Beta-lactamase	9	0	0	9
bromodomain adjacent to zinc finger domain 2B	9	0	0	9
Gamma-aminobutyric acid receptor subunit rho-1	0	1	2	3
Glutamate receptor 1	0	1	0	1
Glutamate receptor 2	0	1	0	1
Glutamate receptor 3	0	1	0	1
Glutamate receptor ionotropic, kainate 3	0	1	0	1
Solute carrier family 15 member 1	0	3	0	3
Glutamate receptor 4	0	1	0	1
Solute carrier family 15 member 1	0	2	0	2
Solute carrier family 15 member 2	0	2	0	3
G	20	0	0	20
ATP-binding cassette sub-family C member 3	0	43	0	43
Multidrug resistance-associated protein 4	0	43	0	45
Interferon beta	26	0	0	26
HLA class I histocompatibility antigen, B alpha chain	20	0	0	20
Aromatase	0	5	0	5
Cytochrome P450 2C9	0	18	2	20
Amine oxidase [flavin-containing] A	0	1	1	2
UDP-glucuronosyltransferase 1A4	0	1	0	5
Spike glycoprotein	24	2	5	31
Inositol hexakisphosphate kinase 1	20	0	0	20
Canalicular multispecific organic anion transporter 1	0	41	0	41
cytochrome P450 2C9, partial	20	0	0	20
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	2	2
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	2	2
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	2	2
thioredoxin reductase	23	0	0	23
GLS protein	15	0	0	15
thyroid stimulating hormone receptor	27	0	0	27
alpha-galactosidase	8	0	0	8
cytochrome P450 2C19 precursor	5	0	0	5
chromobox protein homolog 1	23	0	0	23
DNA polymerase iota isoform a (long)	17	0	0	17
lethal factor (plasmid)	11	0	0	11
Cytochrome P450 3A4	0	17	0	21
Nitric oxide synthase, endothelial	0	0	0	2
Nitric oxide synthase, brain	0	0	0	1
Nitric oxide synthase, brain	0	0	0	1
Nitric oxide synthase, inducible	0	0	0	1
Nitric oxide synthase, inducible	0	0	1	3
Cationic amino acid transporter 3	0	2	0	2
Chain A, Hyaluronidase, phage associated	0	1	0	1
GLI family zinc finger 3	38	0	0	38
thioredoxin glutathione reductase	7	0	0	7
IDH1	17	0	0	17
lethal(3)malignant brain tumor-like protein 1 isoform I	1	0	0	1
Polyphenol oxidase 2	0	3	0	5
Pancreatic alpha-amylase	0	2	0	2
Albumin	0	1	0	1
Urease	0	1	0	1
Prolyl 4-hydroxylase subunit alpha-1	0	0	0	1
Tyrosinase	0	1	0	1
Alpha-2B adrenergic receptor	0	12	1	13
Hyaluronate lyase	0	1	0	1
Prolyl hydroxylase EGLN2	0	0	0	1
Egl nine homolog 1	0	0	0	1
Prolyl hydroxylase EGLN3	0	0	0	1
Hypoxia-inducible factor 1-alpha inhibitor	0	0	0	1
Solute carrier family 23 member 1	0	1	0	1
Carbonic anhydrase 1	0	11	0	17
Carbonic anhydrase 2	0	12	1	20
Neutral amino acid transporter A	0	2	0	2
Neutral amino acid transporter B(0)	0	2	0	2
Carbonic anhydrase-like protein, putative	0	0	0	4
Amino acid transporter	0	2	0	2
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	13	0	0	13
Chain A, Phospholipase A2 isoform 3	0	0	1	1
Chain A, HADH2 protein	11	0	0	11
Chain B, HADH2 protein	11	0	0	11
GTP-binding protein (rab7)	0	0	1	1
ras protein, partial	0	0	1	1
interleukin 8	13	0	0	13
aldehyde dehydrogenase 1 family, member A1	34	0	0	34
hypothetical protein, conserved	2	0	0	2
EWS/FLI fusion protein	29	0	0	29
cytochrome P450 2D6	24	0	0	24
glucocerebrosidase	5	0	0	5
peroxisome proliferator-activated receptor delta	25	0	0	25
Rac1 protein	0	0	1	1
cell division cycle 42 (GTP binding protein, 25kDa), partial	0	0	1	1
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	13	0	0	13
DNA polymerase kappa isoform 1	14	0	0	14
Prostaglandin-H2 D-isomerase	0	1	0	1
Prostaglandin G/H synthase 1	0	2	0	2
Prostaglandin G/H synthase 2	0	1	0	1
Epidermal growth factor receptor	0	4	0	4
Fatty acid-binding protein, liver	0	2	0	2
Integrin beta-3	6	1	0	7
Myeloperoxidase	0	3	0	3
Prostaglandin G/H synthase 1	0	3	0	3
Seed linoleate 13S-lipoxygenase-1	0	1	0	1
Integrin alpha-IIb	6	1	0	7
Glutathione hydrolase 1 proenzyme	0	1	0	1
Prostaglandin G/H synthase 1	0	7	0	7
Adenosine receptor A1	0	5	0	8
Adenosine receptor A2a	0	4	0	8
Substance-P receptor	0	2	0	2
Prostaglandin G/H synthase 2	0	8	0	8
Urotensin-2 receptor	0	1	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	1	0	1
Nuclear receptor ROR-gamma	13	0	0	13
Ras-related protein Rab-2A	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-1	23	7	2	32
Prostaglandin G/H synthase 2	0	3	0	3
Rho-associated protein kinase 2	0	1	0	1
Nicotinate phosphoribosyltransferase	0	2	0	2
Solute carrier family 22 member 20	0	3	0	3
Solute carrier family 22 member 6	0	3	0	3
Sigma non-opioid intracellular receptor 1	0	8	1	9
Sigma non-opioid intracellular receptor 1	0	1	1	2
NPYLR7B	0	0	3	3
Small conductance calcium-activated potassium channel protein 3	0	1	1	2
core protein, partial	0	1	0	1
histone acetyltransferase KAT2A isoform 1	12	0	0	12
Solute carrier organic anion transporter family member 1B3	0	13	0	17
Solute carrier organic anion transporter family member 1B1	0	14	0	18
Chain A, Putative fructose-1,6-bisphosphate aldolase	9	0	0	9
Chain A, Cruzipain	6	0	0	6
vitamin D3 receptor isoform VDRA	17	0	0	17
caspase-1 isoform alpha precursor	4	0	0	4
Caspase-7	4	0	0	4
Inositol monophosphatase 1	6	0	0	6
Chain H, Proteasome component PUP1	0	1	0	1
Chain I, Proteasome component PUP3	0	1	0	1
Chain K, Proteasome component PRE2	0	1	0	1
Chain L, Proteasome component C5	0	1	0	1
Chain K, Proteasome component PRE2	0	1	0	1
Chain L, Proteasome component C5	0	1	0	1
Proteasome subunit beta type-11	0	1	0	2
Fumarate hydratase	10	0	0	10
PPM1D protein	4	0	0	4
caspase 7, apoptosis-related cysteine protease	9	0	0	9
estrogen receptor 2 (ER beta)	23	0	0	23
progesterone receptor	26	0	0	26
polyprotein	10	0	0	10
peroxisome proliferator activated receptor gamma	27	0	0	27
caspase-3	9	0	0	9
nuclear receptor subfamily 1, group I, member 2	8	0	0	8
Histone H2A.x	18	0	0	18
Caspase-7	5	0	0	5
caspase-3	5	0	0	5
26S proteasome non-ATPase regulatory subunit 11	0	1	0	1
26S proteasome non-ATPase regulatory subunit 12	0	1	0	1
26S proteasome non-ATPase regulatory subunit 14	0	1	0	1
Proteasome subunit alpha type-7	0	1	0	2
26S proteasome non-ATPase regulatory subunit 3	0	1	0	1
Carbonic anhydrase 12	0	4	0	8
Prothrombin	0	1	0	1
Chymotrypsinogen A	0	2	0	2
Cellular tumor antigen p53	41	0	0	41
Carbonic anhydrase 3	0	3	0	6
Cathepsin B	0	1	0	1
Neutrophil elastase	0	2	0	2
Cathepsin G	0	2	0	2
Lysosomal protective protein	0	1	0	1
Chymotrypsinogen B	0	1	0	1
26S proteasome regulatory subunit 6A	0	1	0	1
Nuclear factor NF-kappa-B p105 subunit	0	1	0	1
Proteasome subunit beta type-1	0	1	0	3
Carbonic anhydrase 4	0	5	0	9
Carbonic anhydrase 6	0	3	0	7
Chymase	0	1	0	1
Proteasome subunit alpha type-1	0	1	0	2
Proteasome subunit alpha type-2	0	1	0	2
Proteasome subunit alpha type-3	0	1	0	2
Proteasome subunit alpha type-4	0	1	0	2
Proteasome subunit beta type-8	0	1	0	2
Proteasome subunit beta type-8	0	1	0	1
Proteasome subunit beta type-9	0	1	0	2
Proteasome subunit alpha type-5	0	1	0	2
Proteasome subunit beta type-4	0	1	0	2
Proteasome subunit beta type-6	0	1	0	2
Proteasome subunit beta type-5	0	2	0	4
Carbonic anhydrase 5A, mitochondrial	0	4	0	8
26S proteasome regulatory subunit 7	0	1	0	1
Lon protease homolog, mitochondrial	0	1	0	1
Proteasome subunit beta type-10	0	1	0	2
Carbonic anhydrase 7	0	3	0	7
26S proteasome regulatory subunit 6B	0	1	0	1
26S proteasome non-ATPase regulatory subunit 8	0	1	0	1
Proteasome subunit beta type-3	0	1	0	2
Proteasome subunit beta type-2	0	1	0	3
26S proteasome non-ATPase regulatory subunit 7	0	1	0	1
26S proteasome non-ATPase regulatory subunit 4	0	1	0	1
26S proteasome complex subunit SEM1	0	1	0	1
Proteasome subunit alpha type-6	0	1	1	3
26S proteasome regulatory subunit 4	0	1	0	1
26S proteasome regulatory subunit 8	0	1	0	1
26S proteasome regulatory subunit 10B	0	1	0	1
Beta-carbonic anhydrase 1	0	1	0	1
Nuclear factor NF-kappa-B p100 subunit	0	1	0	1
Transcription factor p65	0	1	0	1
26S proteasome non-ATPase regulatory subunit 2	0	1	0	1
26S proteasome non-ATPase regulatory subunit 6	0	1	0	1
Proteasomal ubiquitin receptor ADRM1	0	1	0	1
Carbonic anhydrase 9	0	5	0	10
ATP-dependent Clp protease proteolytic subunit	0	1	1	2
Carbonic anhydrase 13	0	1	0	2
NACHT, LRR and PYD domains-containing protein 3	0	1	0	1
Proteasome subunit alpha-type 8	0	1	0	2
Proteasome subunit beta type-7	0	1	0	2
26S proteasome non-ATPase regulatory subunit 1	0	1	0	1
Carbonic anhydrase 15	0	3	0	6
Carbonic anhydrase 14	0	3	0	7
26S proteasome non-ATPase regulatory subunit 13	0	1	0	1
Carbonic anhydrase 5B, mitochondrial	0	3	0	7
apical membrane antigen 1, AMA1	5	0	0	5
aryl hydrocarbon receptor	17	0	0	17
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	12	0	0	12
ubiquitin carboxyl-terminal hydrolase 2 isoform a	6	0	0	6
Matrix metalloproteinase-9	0	1	0	1
Disintegrin and metalloproteinase domain-containing protein 17	4	0	0	4
Chain A, Glycogen Phosphorylase	0	1	0	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, Chitinase	0	1	0	1
thyroid stimulating hormone receptor	14	0	0	14
v-jun sarcoma virus 17 oncogene homolog (avian)	18	0	0	18
atrial natriuretic peptide receptor 1 precursor	2	0	0	2
DNA polymerase beta	5	0	0	5
nuclear receptor ROR-gamma isoform 1	12	0	0	12
Potassium channel subfamily K member 2	0	1	1	2
Glycogen phosphorylase, muscle form	0	2	0	2
Renin	0	1	0	1
Cholinesterase	0	2	0	2
Glycogen phosphorylase, liver form	0	1	0	1
Glycogen phosphorylase, muscle form	0	1	0	1
Replicase polyprotein 1ab	0	6	5	11
Adenosine receptor A3	0	8	0	8
Replicase polyprotein 1ab	0	8	5	13
Amine oxidase [flavin-containing] A	0	2	0	2
Acetylcholinesterase	0	5	0	5
Amine oxidase [flavin-containing] B	0	2	0	2
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	2	0	2
Adenosine receptor A3	0	1	0	1
Adenosine receptor A2a	0	11	1	13
Adenosine receptor A2b	0	1	0	2
Adenosine receptor A2b	0	2	0	3
Adenosine receptor A1	0	8	1	11
Vasopressin V2 receptor	0	0	0	1
Serine/threonine-protein kinase mTOR	0	3	0	3
Adenosine receptor A2a	0	1	0	1
Adenosine receptor A1	0	2	0	2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	0	1	0	1
DNA-dependent protein kinase catalytic subunit	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	1	0	1
Adenylate cyclase type 1	0	0	0	1
Chitotriosidase-1	0	1	0	1
Serine-protein kinase ATM	0	1	0	1
Serine/threonine-protein kinase ATR	0	1	0	1
Adenosine receptor A2b	0	1	0	2
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	0	1	0	1
Palmitoleoyl-protein carboxylesterase NOTUM	0	3	2	5
Endochitinase B1	0	1	0	1
Muscarinic acetylcholine receptor	0	0	0	1
Phosphodiesterase	0	1	0	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	6	0	7
Guanine deaminase	0	1	0	1
mitogen-activated protein kinase 1	13	0	0	13
Vpr	3	0	0	3
Bile salt export pump	0	10	0	10
Albumin	0	0	2	2
Major prion protein	0	0	4	4
Sodium channel protein type 1 subunit alpha	0	2	0	2
Sodium channel protein type 2 subunit alpha	0	3	0	3
Sodium channel protein type 3 subunit alpha	0	2	0	2
UDP-glucuronosyltransferase 2B7	0	0	0	3
Cytochrome P450 2B6	0	3	2	5
Sodium channel protein type 4 subunit alpha	0	4	0	7
Cytochrome P450 2J2	0	8	0	8
Potassium voltage-gated channel subfamily H member 2	0	17	0	18
Sodium channel protein type 9 subunit alpha	0	5	0	5
Frizzled-8	0	0	1	1
P2X purinoceptor 4	0	2	0	2
Lactoperoxidase	0	1	0	1
ras-related protein Rab-9A	6	0	0	6
cytochrome P450 3A4 isoform 1	23	0	0	23
Gamma-aminobutyric acid receptor subunit pi	23	6	1	30
Rap guanine nucleotide exchange factor 3	4	0	0	4
Gamma-aminobutyric acid receptor subunit beta-1	23	6	1	30
Gamma-aminobutyric acid receptor subunit delta	23	6	1	30
Gamma-aminobutyric acid receptor subunit gamma-2	23	6	2	31
Gamma-aminobutyric acid receptor subunit alpha-5	23	6	1	30
Gamma-aminobutyric acid receptor subunit alpha-3	23	6	1	30
Gamma-aminobutyric acid receptor subunit gamma-1	23	6	1	30
Gamma-aminobutyric acid receptor subunit alpha-2	23	6	1	30
Gamma-aminobutyric acid receptor subunit alpha-4	23	6	1	30
Gamma-aminobutyric acid receptor subunit gamma-3	23	6	1	30
Gamma-aminobutyric acid receptor subunit alpha-6	23	6	1	30
Gamma-aminobutyric acid receptor subunit beta-3	23	6	1	30
Gamma-aminobutyric acid receptor subunit beta-2	23	6	2	31
GABA theta subunit	23	6	1	30
Gamma-aminobutyric acid receptor subunit epsilon	23	6	1	30
B2 metallo-beta-lactamase	0	0	0	1
Solute carrier family 15 member 2	0	1	0	1
Solute carrier family 22 member 8	0	4	0	5
Luciferase	10	0	0	10
GALC protein	6	0	0	6
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	7	0	0	7
activating transcription factor 6	15	0	0	15
peripheral myelin protein 22 isoform 1	10	0	0	10
potassium voltage-gated channel subfamily H member 2 isoform d	12	0	0	12
FAD-linked sulfhydryl oxidase ALR	0	0	0	2
urokinase-type plasminogen activator precursor	14	0	0	14
plasminogen precursor	14	0	0	14
urokinase plasminogen activator surface receptor precursor	14	0	0	14
muscleblind-like protein 1 isoform 1	5	0	0	5
Cytochrome P450 2D6	0	10	1	11
Carbonic anhydrase	0	1	0	4
glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase	0	1	0	1
Spike glycoprotein	0	2	5	7
Replicase polyprotein 1ab	0	2	5	7
glucose-6-phosphate 1-dehydrogenase isoform b	0	1	0	1
Transmembrane protease serine 2	0	2	5	7
Dihydrofolate reductase	0	4	0	4
DNA ligase	0	1	0	1
Riboflavin-binding protein	0	2	3	5
Amyloid-beta precursor protein	1	3	0	4
Histidine-rich protein PFHRP-II	0	2	0	3
Procathepsin L	0	2	5	7
Muscarinic acetylcholine receptor M2	0	11	0	11
Muscarinic acetylcholine receptor M4	0	10	0	10
Muscarinic acetylcholine receptor M5	0	10	0	10
Alpha-2A adrenergic receptor	0	12	0	12
Replicase polyprotein 1a	0	2	5	7
Replicase polyprotein 1ab	0	2	5	7
Spike glycoprotein	0	1	0	1
Muscarinic acetylcholine receptor M1	0	11	1	12
Ribosyldihydronicotinamide dehydrogenase [quinone]	0	4	0	4
Alpha-2C adrenergic receptor	0	10	0	10
DNA ligase 1	0	1	0	1
Muscarinic acetylcholine receptor M3	0	12	0	12
Nuclear receptor subfamily 4 group A member 2	0	0	2	2
Beta-secretase 1	0	1	0	1
Calcium-dependent protein kinase 1	0	0	1	1
MO15-related protein kinase Pfmrk	0	1	0	1
DNA ligase A	0	1	0	1
Sigma intracellular receptor 2	0	2	0	2
Phosphoethanolamine N-methyltransferase	0	1	0	1
Angiotensin-converting enzyme 2	0	2	5	7
Cysteine proteinase falcipain 2a	0	1	0	1
Cysteine proteinase falcipain 2a	0	1	0	1
endonuclease IV	6	0	0	6
ATAD5 protein, partial	13	0	0	13
Smad3	9	0	0	9
NADPH oxidase 1	0	1	0	1
67.9K protein	13	0	0	13
Snq2p	0	0	0	1
Adenylate cyclase type 1	0	2	0	2
cytochrome P450 2D6 isoform 1	7	0	0	7
cellular tumor antigen p53 isoform a	6	0	0	6
histone deacetylase 9 isoform 3	2	0	0	2
atrial natriuretic peptide receptor 2 precursor	1	0	0	1
serine/threonine-protein kinase mTOR isoform 1	6	0	0	6
M-phase phosphoprotein 8	10	0	0	10
Solute carrier family 22 member 1	0	7	0	7
Polyunsaturated fatty acid lipoxygenase ALOX15B	4	0	0	4
Glutamate receptor ionotropic, NMDA 2D	0	1	0	1
Transient receptor potential cation channel subfamily V member 1	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1F	0	5	0	5
5-hydroxytryptamine receptor 4	0	10	0	10
Albumin	0	2	5	11
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	0	2	0	2
Receptor tyrosine-protein kinase erbB-2	0	2	0	2
Major prion protein	0	1	1	2
Cytochrome P450 1A2	0	7	1	8
Aldo-keto reductase family 1 member B1	0	18	0	18
ATP-dependent translocase ABCB1	0	11	2	15
Muscarinic acetylcholine receptor M1	0	2	0	2
Muscarinic acetylcholine receptor M3	0	2	0	2
Muscarinic acetylcholine receptor M4	0	2	0	2
5-hydroxytryptamine receptor 1A	0	2	1	3
5-hydroxytryptamine receptor 2C	0	4	0	5
Muscarinic acetylcholine receptor M5	0	2	0	2
Cys-loop ligand-gated ion channel	0	1	0	1
Calmodulin-1	0	2	1	3
Muscarinic acetylcholine receptor M2	0	2	0	2
Polyunsaturated fatty acid lipoxygenase ALOX15	0	6	0	6
Angiotensin-converting enzyme	0	5	0	5
D(2) dopamine receptor	0	8	0	9
5-hydroxytryptamine receptor 2A	0	4	0	4
Alpha-1B adrenergic receptor	0	12	0	12
Sphingomyelin phosphodiesterase	0	1	0	1
D	0	3	0	3
D(3) dopamine receptor	0	3	0	3
5-hydroxytryptamine receptor 1A	0	6	0	6
Alpha-2B adrenergic receptor	0	3	0	3
D(2) dopamine receptor	0	1	0	1
Substance-K receptor	0	12	0	12
D(1A) dopamine receptor	0	8	0	9
D(4) dopamine receptor	0	6	0	7
D(1B) dopamine receptor	0	1	0	2
Adenylate cyclase type 3	0	2	0	2
Alpha-2C adrenergic receptor	0	3	0	3
Alpha-2A adrenergic receptor	0	3	0	3
Alpha-1D adrenergic receptor	0	6	0	6
Sodium-dependent noradrenaline transporter	0	19	0	19
Sodium-dependent dopamine transporter	0	3	0	3
Histamine H2 receptor	0	10	0	10
Alpha-1D adrenergic receptor	0	14	0	14
D(1B) dopamine receptor	0	2	0	2
Adenylate cyclase type 2	0	2	0	2
Adenylate cyclase type 4	0	2	0	2
5-hydroxytryptamine receptor 2A	0	10	0	10
5-hydroxytryptamine receptor 2C	0	10	0	10
5-hydroxytryptamine receptor 1B	0	4	0	4
Trypanothione reductase	0	4	0	4
D(4) dopamine receptor	0	3	0	3
5-hydroxytryptamine receptor 2B	0	3	0	3
Histamine H1 receptor	0	2	2	4
Sodium-dependent serotonin transporter	0	14	0	14
Melanocortin receptor 4	0	4	0	4
5-hydroxytryptamine receptor 7	0	1	0	1
Melanocortin receptor 5	0	4	0	4
Pleiotropic ABC efflux transporter of multiple drugs	0	1	0	2
5-hydroxytryptamine receptor 7	0	2	0	2
Histamine H1 receptor	0	4	1	5
Mu-type opioid receptor	0	11	1	12
Glutamate receptor ionotropic, NMDA 1	0	2	0	5
D(3) dopamine receptor	0	10	0	11
Sodium channel protein type 1 subunit alpha	0	2	0	2
Adenylate cyclase type 8	0	2	0	2
Delta-type opioid receptor	0	7	0	7
Kappa-type opioid receptor	0	11	0	11
5-hydroxytryptamine receptor 2B	0	10	0	10
Melanocortin receptor 3	0	4	0	4
Alpha-1A adrenergic receptor	0	13	0	13
Histamine H2 receptor	10	2	1	13
D(1A) dopamine receptor	3	0	0	3
5-hydroxytryptamine receptor 6	0	10	0	10
5-hydroxytryptamine receptor 7	0	1	0	1
Gastrin/cholecystokinin type B receptor	0	1	0	1
D(2) dopamine receptor	0	4	0	5
Calmodulin	0	1	1	2
Aldehyde oxidase 1	0	2	0	2
Glutamate receptor ionotropic, NMDA 2A	0	1	0	4
Glutamate receptor ionotropic, NMDA 2B	0	1	0	4
Glutamate receptor ionotropic, NMDA 2C	0	1	0	4
Sodium channel protein type 7 subunit alpha	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	5	0	5
Sodium-dependent dopamine transporter	0	10	0	10
Adenylate cyclase type 6	0	2	0	2
Adenylate cyclase type 5	0	2	0	2
Glutamate receptor ionotropic, NMDA 1	0	1	0	1
Aldehyde oxidase	0	6	0	6
Glutamate receptor ionotropic, NMDA 2A	0	1	0	1
Glutamate receptor ionotropic, NMDA 2B	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	5	0	5
Voltage-dependent L-type calcium channel subunit alpha-1C	0	7	0	7
Sodium channel protein type 5 subunit alpha	0	4	0	4
Glutamate receptor ionotropic, NMDA 2C	0	1	0	1
Glutamate receptor ionotropic, NMDA 2D	0	1	0	4
Nuclear receptor subfamily 3 group C member 3	0	5	0	5
Adenylyl cyclase 7	0	2	0	2
Glutamate receptor ionotropic, NMDA 3A	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	1	0	4
D	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	3	0	3
Sodium channel protein type 3 subunit alpha	0	3	0	3
Glutamate receptor ionotropic, NMDA 3A	0	1	0	4
Sodium channel protein type 11 subunit alpha	0	1	0	1
Sodium channel protein type 8 subunit alpha	0	1	0	1
Histamine H3 receptor	0	2	0	2
Sodium channel protein type 10 subunit alpha	0	2	0	2
Solute carrier family 22 member 1	0	2	0	2
Solute carrier family 22 member 2	0	5	0	6
Solute carrier family 22 member 2	0	1	0	1
cGMP-specific 3',5'-cyclic phosphodiesterase	0	1	0	1
ATP-dependent translocase ABCB1	0	4	0	4
Potassium-transporting ATPase alpha chain 1	0	1	0	1
ATP-dependent translocase ABCB1	0	4	0	4
Potassium-transporting ATPase subunit beta	0	1	0	1
Solute carrier family 22 member 6	0	4	0	7
Solute carrier family 22 member 1	0	3	0	3
Multidrug and toxin extrusion protein 2	0	4	0	4
Solute carrier family 22 member 8	0	4	0	9
Multidrug and toxin extrusion protein 1	0	6	0	6
Histamine H4 receptor	0	1	0	1
Solute carrier family 22 member 11	0	2	0	5
Solute carrier family 22 member 2	0	2	0	2
Solute carrier family 22 member 4	0	1	0	1
cytochrome P450 2C9 precursor	6	0	0	6
DNA gyrase subunit B	0	1	0	1
DNA gyrase subunit A	0	1	0	1
DNA gyrase subunit B	0	1	0	2
DNA gyrase subunit A	0	1	0	3
DNA gyrase subunit B	0	1	0	3
DNA topoisomerase 4 subunit A	0	1	0	1
DNA topoisomerase 4 subunit B	0	1	0	2
DNA topoisomerase 4 subunit A	0	1	0	2
DNA topoisomerase 2-alpha	0	1	0	4
DNA gyrase subunit A	0	1	0	2
Cytochrome P450 2C19	0	4	0	4
Multidrug resistance protein MdtK	0	0	1	1
DNA gyrase subunit B	0	2	0	2
DNA gyrase subunit A	0	2	0	2
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	1	0	2
DNA topoisomerase 4 subunit A	0	1	0	1
DNA topoisomerase 4 subunit B	0	1	0	1
Integrase	0	2	0	2
Gamma-aminobutyric acid receptor subunit pi	0	5	0	5
Gamma-aminobutyric acid receptor subunit delta	0	5	0	5
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	0	2
Gamma-aminobutyric acid receptor subunit beta-1	0	1	0	2
Neuronal acetylcholine receptor subunit alpha-4	2	1	0	3
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	0	2
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	0	2
Neuronal acetylcholine receptor subunit beta-2	2	1	0	3
Gamma-aminobutyric acid receptor subunit alpha-1	0	6	2	8
Gamma-aminobutyric acid receptor subunit beta-1	0	5	2	7
Gamma-aminobutyric acid receptor subunit gamma-2	0	6	2	8
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	0	2
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	0	2
Gamma-aminobutyric acid receptor subunit beta-3	0	6	2	8
Translocator protein	0	1	0	1
Translocator protein	0	1	0	1
Cholecystokinin receptor type A	0	1	0	1
Gastrin/cholecystokinin type B receptor	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	5	2	7
Gamma-aminobutyric acid receptor subunit alpha-3	0	5	2	7
Gamma-aminobutyric acid receptor subunit alpha-2	0	5	2	7
Gamma-aminobutyric acid receptor subunit beta-2	0	5	2	7
Gamma-aminobutyric acid receptor subunit alpha-4	0	5	2	7
Gamma-aminobutyric acid receptor subunit epsilon	0	5	0	5
Gamma-aminobutyric acid receptor subunit alpha-6	0	5	2	7
Gamma-aminobutyric acid receptor subunit gamma-1	0	5	0	5
Gamma-aminobutyric acid receptor subunit gamma-3	0	5	0	5
Gamma-aminobutyric acid receptor subunit theta	0	5	0	5
Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial	0	0	0	1
Glutathione S-transferase P	0	1	0	1
Alpha-tocopherol transfer protein	0	0	1	1
hypoxia-inducible factor 1 alpha subunit	10	0	0	10
SMAD family member 2	14	0	0	14
SMAD family member 3	14	0	0	14
Lysine-specific demethylase 6B	0	1	0	1
Lysine-specific demethylase 4A	0	3	1	4
Lysine-specific demethylase 5A	0	1	0	1
Flavin reductase (NADPH)	0	0	1	1
Potassium voltage-gated channel subfamily D member 3	0	1	0	1
nonstructural protein 1	5	0	0	5
Lysine-specific demethylase 6A	0	1	0	1
Lysine-specific demethylase 5C	0	1	0	1
Lysine-specific demethylase 2B	0	1	0	1
Deoxyhypusine hydroxylase	0	2	0	2
Lysine-specific demethylase 2A	0	1	0	1
Hypoxia-inducible factor 1-alpha	0	0	1	1
Methylcytosine dioxygenase TET2	0	1	0	1
Thymidine kinase, cytosolic	0	4	0	7
Deoxycytidine kinase	0	0	0	1
AAA family ATPase	0	0	0	1
Sterol O-acyltransferase 1	0	1	0	1
Chain A, Ferritin light chain	11	0	0	11
glp-1 receptor, partial	7	0	0	7
serine/threonine-protein kinase PLK1	3	0	0	3
histone-lysine N-methyltransferase 2A isoform 2 precursor	4	0	0	4
high affinity choline transporter 1 isoform a	0	1	0	1
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	2	0	0	2
neuropeptide S receptor isoform A	5	0	0	5
Nuclear receptor subfamily 1 group I member 2	0	1	4	5
Estrogen receptor	0	12	3	16
Glucocorticoid receptor	0	12	2	19
Glycine receptor subunit alpha-1	0	12	0	12
Beta-1 adrenergic receptor	0	4	0	4
Polyunsaturated fatty acid 5-lipoxygenase	0	2	0	2
Androgen receptor	0	14	0	14
Glycine receptor subunit beta	0	12	0	12
Glycine receptor subunit alpha-2	0	12	0	12
Glycine receptor subunit alpha-3	0	12	0	12
Thromboxane-A synthase	0	4	0	4
Vasopressin V1a receptor	0	4	0	4
Alpha-synuclein	5	3	0	8
Estrogen-related receptor gamma	0	1	1	2
UDP-glucose 4-epimerase	0	1	0	1
Mitogen-activated protein kinase 14	0	1	0	1
Estrogen receptor beta	0	7	3	10
Cysteinyl leukotriene receptor 1	0	2	0	2
lysosomal alpha-glucosidase preproprotein	4	0	0	4
Cytochrome P450 2B1	0	1	0	1
Sex hormone-binding globulin	0	0	2	2
UDP-glucuronosyltransferase 1A1	0	2	0	3
3-oxo-5-alpha-steroid 4-dehydrogenase 1	0	1	0	1
Sulfotransferase 1A1	0	2	1	4
Nuclear receptor subfamily 1 group I member 3	0	1	0	1
Chain A, BCL-2-RELATED PROTEIN A1	0	0	1	1
unnamed protein product	0	1	0	1
transcriptional regulator ERG isoform 3	5	0	0	5
heat shock protein HSP 90-alpha isoform 2	0	1	0	2
bcl-2-like protein 11 isoform 1	0	0	1	1
Beta-lactamase	0	1	0	1
Steroid 17-alpha-hydroxylase/17,20 lyase	0	1	0	1
Heme oxygenase 1	0	1	0	1
Lanosterol 14-alpha demethylase	0	1	2	3
Cytochrome P450 11B1, mitochondrial	0	1	0	1
Cytochrome P450 11B2, mitochondrial	0	1	0	1
Heme oxygenase 2	0	1	0	1
Malate dehydrogenase, cytoplasmic	0	1	0	1
Cytochrome P450 144	0	0	2	2
Steroid C26-monooxygenase	0	0	2	2
Steroid C26-monooxygenase	0	0	2	2
Mycocyclosin synthase	0	0	1	1
Lanosterol 14-alpha demethylase	0	0	1	1
Lanosterol 14-alpha demethylase	0	0	1	1
Lanosterol 14-alpha demethylase	0	3	1	4
Sterol 14-alpha demethylase	0	0	2	2
Sterol 14-alpha demethylase	0	1	1	2
14-alpha sterol demethylase	0	0	2	2
heat shock protein 90, putative	0	0	0	1
likely tRNA 2'-phosphotransferase	0	1	0	1
Chain A, Uracil Phosphoribosyltransferase	0	1	0	1
Skn7p	0	0	0	1
hemoglobin subunit beta	1	0	0	1
huntingtin isoform 2	2	0	0	2
Solute carrier family 22 member 8	0	0	0	1
Thymidylate synthase	0	4	0	4
HSP40, subfamily A [Plasmodium falciparum 3D7]	0	0	0	1
Cocaine esterase	0	1	0	2
Androgen receptor	0	4	0	4
Arylacetamide deacetylase	0	1	0	3
Arylacetamide deacetylase	0	0	0	1
Arylacetamide deacetylase	0	0	0	1
Chain A, Dihydrofolate reductase	0	0	1	1
acid sphingomyelinase	2	0	0	2
Thymidylate synthase	0	4	0	4
Dihydrofolate reductase	0	6	4	11
Aldo-keto reductase family 1 member B1	0	2	0	2
Folylpolyglutamate synthase, mitochondrial	0	1	0	4
Solute carrier organic anion transporter family member 1A3	0	1	0	3
Folylpolyglutamate synthase, mitochondrial	0	1	0	4
Multidrug resistance associated protein	0	1	0	3
thyrotropin-releasing hormone receptor	5	0	0	5
Glucose-6-phosphate 1-dehydrogenase	0	3	0	3
Serum paraoxonase/arylesterase 1	0	1	0	1
Corticosteroid 11-beta-dehydrogenase isozyme 1	0	2	1	3
Corticosteroid 11-beta-dehydrogenase isozyme 1	0	2	1	3
6-phosphogluconate dehydrogenase, decarboxylating	0	2	0	2
Holo-[acyl-carrier-protein] synthase	0	1	0	1
Solute carrier organic anion transporter family member 2A1	0	1	0	1
Sodium/bile acid cotransporter	0	2	0	2
Carbonic anhydrase 13	0	2	0	5
G-protein coupled receptor 35	0	1	1	2
CDGSH iron-sulfur domain-containing protein 1	0	4	0	4
Voltage-dependent calcium channel subunit alpha-2/delta-1	0	1	0	1
Gamma-aminobutyric acid	0	1	1	2
Gamma-aminobutyric acid receptor subunit rho-3	0	0	1	1
Hsf1 protein	0	0	4	6
Gamma-aminobutyric acid type B receptor subunit 2	0	0	1	1
Gamma-aminobutyric acid type B receptor subunit 2	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	1	1	2
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	1	2
Gamma-aminobutyric acid receptor subunit delta	0	1	1	2
Sodium- and chloride-dependent GABA transporter 1	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	1	2
Gamma-aminobutyric acid receptor subunit gamma-3	0	1	1	2
Gamma-aminobutyric acid receptor subunit rho-2	0	0	1	1
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Sodium- and chloride-dependent taurine transporter	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	2	0	2
Sodium- and chloride-dependent GABA transporter 3	0	2	0	2
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Sodium- and chloride-dependent betaine transporter	0	2	0	2
Sodium- and chloride-dependent betaine transporter	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	1	2
Gamma-aminobutyric acid receptor subunit beta-3	0	1	1	2
4-aminobutyrate aminotransferase, mitochondrial	0	0	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	0	0	1
Sterol O-acyltransferase 1	0	0	1	1
Proton-coupled amino acid transporter 1	0	3	0	4
Gamma-aminobutyric acid receptor subunit alpha-5	0	1	1	2
Gamma-aminobutyric acid receptor subunit pi	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	1	2
Platelet glycoprotein VI	0	0	2	2
Gamma-aminobutyric acid receptor subunit theta	0	1	1	2
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	1	1	2
Gamma-aminobutyric acid type B receptor subunit 1	0	0	1	1
Gamma-aminobutyric acid type B receptor subunit 1	0	1	0	1
Chain B, EUKARYOTIC TRANSLATION INITIATION FACTOR 4E	0	0	1	1
Pancreatic alpha-amylase	0	1	0	1
Beta-glucuronidase	0	1	0	1
Beta-glucuronidase	0	1	0	1
High mobility group protein B1	0	0	3	3
Tyrosine-protein phosphatase non-receptor type 1	0	2	0	4
High mobility group protein B1	0	0	0	1
Corticosteroid 11-beta-dehydrogenase isozyme 2	0	1	1	2
Canalicular multispecific organic anion transporter 1	0	3	0	5
Solute carrier organic anion transporter family member 1B2	0	1	0	1
Chain A, HISTIDINE-BINDING PROTEIN	0	0	1	1
Plasma kallikrein	0	0	0	3
Histidine-binding periplasmic protein	0	0	1	1
5-hydroxytryptamine receptor 1D	0	0	0	1
Carbonic anhydrase	0	0	0	3
Large neutral amino acids transporter small subunit 1	0	4	0	4
Glutaminyl-peptide cyclotransferase	0	1	0	1
Carbonic anhydrase	0	0	0	3
Carbonic anhydrase	0	0	0	3
Carbonic anhydrase	0	0	0	3
Carbonic anhydrase	0	0	0	3
Carbonic anhydrase 4	0	0	0	1
Genome polyprotein	0	1	0	1
Cyclic GMP-AMP synthase	0	2	0	2
Toll-like receptor 9	0	1	0	1
Toll-like receptor 7	0	1	1	2
Uracil nucleotide/cysteinyl leukotriene receptor	0	2	0	2
Stromelysin-1	0	2	2	4
Urease subunit alpha	0	1	0	1
Ribonucleoside-diphosphate reductase large subunit	0	1	0	1
Urease subunit beta	0	1	0	1
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	3	0	0	3
DNA repair protein RAD52 homolog isoform a	0	0	0	1
Tyrosine-protein kinase ABL1	0	1	2	3
Cytochrome P450 2C8	0	0	0	1
Mast/stem cell growth factor receptor Kit	0	1	1	2
Breakpoint cluster region protein	0	0	1	1
Platelet-derived growth factor receptor alpha	0	1	1	2
Cytochrome P450 3A5	0	3	0	4
7,8-dihydro-8-oxoguanine triphosphatase	0	1	0	1
Toll-like receptor 8	0	0	1	1
Chain A, PROTEIN (PROTEASE)	0	1	0	1
Chain B, PROTEIN (PROTEASE)	0	1	0	1
Chain A, PROTEIN (PROTEASE)	0	1	0	1
Chain B, PROTEIN (PROTEASE)	0	1	0	1
Chain A, HIV-1 PROTEASE	0	1	0	1
Chain B, HIV-1 PROTEASE	0	1	0	1
Chain A, HIV-II PROTEASE	0	1	0	1
Chain B, HIV-II PROTEASE	0	1	0	1
Chain A, POL polyprotein	0	0	1	1
Chain B, POL polyprotein	0	0	1	1
Chain A, POL polyprotein	0	0	1	1
Chain B, POL polyprotein	0	0	1	1
Chain A, POL polyprotein	0	0	1	1
Chain B, POL polyprotein	0	0	1	1
Chain A, POL polyprotein	0	0	1	1
Chain B, POL polyprotein	0	0	1	1
Chain A, protease RETROPEPSIN	0	1	0	1
Chain B, protease RETROPEPSIN	0	1	0	1
Chain A, protease RETROPEPSIN	0	1	0	1
Chain B, protease RETROPEPSIN	0	1	0	1
Chain A, protease RETROPEPSIN	0	1	0	1
Chain B, protease RETROPEPSIN	0	1	0	1
Chain A, POL polyprotein	0	2	0	2
Chain B, POL polyprotein	0	2	0	2
Chain A, POL polyprotein	0	2	0	2
Chain B, POL polyprotein	0	2	0	2
Chain A, HIV-1 protease	0	1	0	1
Chain B, HIV-1 protease	0	1	0	1
Chain A, Pol polyprotein	0	1	0	1
Chain B, Pol polyprotein	0	1	0	1
Chain A, Pol polyprotein	0	1	0	1
Chain B, Pol polyprotein	0	1	0	1
Chain A, Pol polyprotein	0	1	0	1
Chain B, Pol polyprotein	0	1	0	1
Chain A, Pol polyprotein	0	1	0	1
Chain B, Pol polyprotein	0	1	0	1
Chain A, Hiv-1 Protease	0	1	0	1
Chain B, Hiv-1 Protease	0	1	0	1
Chain A, Hiv-1 Protease	0	1	0	1
Chain B, Hiv-1 Protease	0	1	0	1
Chain A, Hiv-1 Protease	0	1	0	1
Chain B, Hiv-1 Protease	0	1	0	1
Solute carrier family 22 member 3	0	2	0	2
Gag-Pol polyprotein	0	3	0	3
Gag-Pol polyprotein	0	1	0	1
Gag-Pol polyprotein	0	3	0	3
Gag polyprotein	0	1	0	1
Gag-Pol polyprotein	0	2	0	2
Gag-Pol polyprotein	0	4	0	4
Gag-Pol polyprotein	0	2	0	2
Thromboxane-A synthase	0	0	0	2
Genome polyprotein	0	1	0	1
Protease	0	6	3	16
Protease	0	5	2	7
Protease	0	1	0	1
Cytochrome P450 1A1	0	3	0	3
Capsid protein	0	1	2	3
Reverse transcriptase/RNaseH	0	3	5	14
Potassium voltage-gated channel subfamily E member 1	0	1	0	1
Potassium voltage-gated channel subfamily KQT member 1	0	1	0	1
Nonstructural protein 5A	0	1	1	2
Chain A, AMINOPEPTIDASE	0	1	0	1
Chain A, AMINOPEPTIDASE	0	1	0	1
Chain A, Leucine Aminopeptidase	0	1	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	2	0	2
Intestinal-type alkaline phosphatase	0	2	0	2
Phospholipase A-2-activating protein	0	2	0	2
chaperonin-containing TCP-1 beta subunit homolog	2	0	0	2
Synaptic vesicle glycoprotein 2A	0	2	0	2
Type-1A angiotensin II receptor	0	1	0	1
Type-1B angiotensin II receptor	0	2	0	2
Type-2 angiotensin II receptor	0	1	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase B	0	1	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase A	0	1	0	1
5-hydroxytryptamine receptor 1A	0	1	0	1
Type-1 angiotensin II receptor	0	1	0	1
Chain A, Antigen Cd11a (p180)	0	1	0	1
PINK1	2	0	0	2
isocitrate dehydrogenase 1, partial	1	0	0	1
Parkin	2	0	0	2
bcl-2-related protein A1	0	2	0	2
3-hydroxy-3-methylglutaryl-coenzyme A reductase	0	4	0	4
Integrin beta-2	0	1	0	1
Intercellular adhesion molecule 1	0	1	0	1
Insulin receptor	0	3	0	3
Integrin alpha-L	0	1	1	2
3-hydroxy-3-methylglutaryl-coenzyme A reductase	0	4	0	4
Rap guanine nucleotide exchange factor 4	2	0	0	2
Acyl-CoA:cholesterol acyltransferase	0	1	0	1
retinoic acid receptor alpha isoform 1	0	1	0	1
retinoic acid receptor RXR-alpha isoform a	0	1	0	1
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplast	0	1	0	1
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplast	0	1	0	1
Glutathione reductase, mitochondrial	0	3	0	3
ClpP	2	0	0	2
Cytochrome P450 1A2	0	1	0	1
Cytochrome P450 2C11	0	1	0	1
Metabotropic glutamate receptor 1	0	1	0	1
Acetylcholinesterase	0	1	0	1
Mu-type opioid receptor	0	2	0	2
Nociceptin receptor	0	1	0	1
Melatonin receptor type 1A	0	2	1	3
Melatonin receptor type 1C	0	0	1	1
Melatonin receptor type 1A	0	1	1	2
Melatonin receptor type 1B	0	2	1	3
Melatonin receptor type 1C	0	1	1	2
Melatonin receptor type 1B	0	1	1	2
Nuclear factor erythroid 2-related factor 2	0	0	0	1
Carboxylic ester hydrolase	0	1	0	1
Liver carboxylesterase 1	0	0	0	1
Sodium-dependent serotonin transporter	0	1	0	1
Delta-type opioid receptor	0	1	0	1
Kappa-type opioid receptor	0	1	0	1
Mu-type opioid receptor	0	1	0	1
Mu-type opioid receptor	0	1	0	1
cystic fibrosis transmembrane conductance regulator ATP-binding cassette sub-family C member 7	0	0	0	1
Cannabinoid receptor 1	0	2	0	2
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Thymidylate synthase	0	1	0	1
Thymidylate synthase	0	1	0	1
polyunsaturated fatty acid lipoxygenase ALOX12	1	0	0	1
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]	0	1	0	1
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	3	0	0	3
DNA polymerase eta isoform 1	1	0	0	1
transactivating tegument protein VP16 [Human herpesvirus 1]	0	2	0	2
nuclear receptor coactivator 3 isoform a	0	1	0	1
Toll-like receptor 4	0	1	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
ATP-binding cassette sub-family C member 3	0	1	0	2
Dihydrofolate reductase	0	7	0	8
Dihydrofolate reductase	0	2	0	3
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	2	0	3
Thymidylate synthase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Thymidylate synthase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	3	0	3
Folate receptor beta	0	1	0	1
Cytochrome P450 11B1, mitochondrial	0	1	0	1
Folate receptor alpha	0	1	0	1
Dihydrofolate reductase	0	4	0	4
Histidine decarboxylase	0	1	0	1
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Cyclin-dependent kinase 2	0	0	1	1
Bifunctional purine biosynthesis protein ATIC	0	2	0	2
Multidrug resistance-associated protein 1	0	0	0	1
Delta-type opioid receptor	0	1	0	1
Kappa-type opioid receptor	0	1	0	1
Reduced folate transporter	0	2	0	2
Dihydrofolate reductase	0	1	0	1
Pteridine reductase 1	0	2	0	2
Bifunctional dihydrofolate reductase-thymidylate synthase	0	2	0	2
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	2	0	2
ATP-binding cassette sub-family C member 11	0	0	0	1
Proton-coupled folate transporter	0	1	0	1
Protein-arginine deiminase type-4	0	2	0	2
Tyrosinase	0	2	0	2
Sepiapterin reductase	0	1	0	1
large T antigen	0	1	0	1
BRCA1	1	0	0	1
Estrogen receptor 1	0	1	0	1
NPC intracellular cholesterol transporter 1 precursor	3	0	0	3
Chain B, Exotoxin A	0	0	1	1
Chain B, Exotoxin A	0	0	1	1
Chain B, Exotoxin A	0	0	1	1
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	3
Hormone-sensitive lipase	0	1	0	1
Aldo-keto reductase family 1 member C4	0	1	0	1
Caspase-1	0	2	0	2
Prostaglandin G/H synthase 2	0	1	0	2
Aldo-keto reductase family 1 member C3	0	1	0	1
Caspase-3	0	1	0	1
Caspase-4	0	1	0	1
Caspase-5	0	1	0	1
Aldo-keto reductase family 1 member C2	0	1	0	1
Caspase-9	0	1	0	1
Aldo-keto reductase family 1 member C1	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	2
Cholesteryl ester transfer protein	0	1	0	1
D-amino-acid oxidase	0	1	0	1
Hydroxycarboxylic acid receptor 3	0	0	1	1
Nicotinamidase	0	1	0	1
Hydroxycarboxylic acid receptor 2	0	0	1	1
Hydroxycarboxylic acid receptor 2	0	2	1	3
D-aspartate oxidase	0	1	0	1
Hydroxycarboxylic acid receptor 2	0	1	1	2
Chain A, NAD-dependent deacetylase	0	1	0	1
Poly [ADP-ribose] polymerase 2	0	1	0	1
NAD-dependent histone deacetylase SIR2	0	1	0	1
Coagulation factor VII	0	1	0	1
Poly [ADP-ribose] polymerase 1	0	1	0	1
Tissue factor	0	1	0	1
NAD-dependent protein deacetylase HST2	0	1	0	1
Fatty-acid amide hydrolase 1	0	2	0	2
NAD(+) hydrolase SARM1	0	1	0	1
NAD-dependent protein deacetylase sirtuin-2	0	1	0	1
NAD-dependent protein deacetylase sirtuin-6	0	1	0	1
NAD-dependent protein deacetylase sirtuin-1	0	1	0	1
NAD-dependent protein deacetylase sirtuin-3, mitochondrial	0	1	0	1
NAD-dependent protein deacylase sirtuin-5, mitochondrial	0	1	0	1
NAD-dependent protein deacetylase	0	1	0	1
4-hydroxyphenylpyruvate dioxygenase	0	1	0	1
4-hydroxyphenylpyruvate dioxygenase	0	1	0	1
4-hydroxyphenylpyruvate dioxygenase	0	1	0	1
streptokinase A precursor	0	0	3	3
Estrogen receptor	0	0	4	5
60 kDa chaperonin	0	3	0	3
Estrogen receptor beta	0	0	4	5
10 kDa chaperonin	0	3	0	3
Progesterone receptor	0	5	2	8
5-hydroxytryptamine receptor 3E	0	1	0	1
5-hydroxytryptamine receptor 3B	0	1	0	1
Alpha-1A adrenergic receptor	0	1	0	1
Alpha-1B adrenergic receptor	0	1	0	1
5-hydroxytryptamine receptor 3A	0	1	0	1
Sigma non-opioid intracellular receptor 1	0	2	0	2
Transporter	0	1	0	1
5-hydroxytryptamine receptor 3D	0	1	0	1
5-hydroxytryptamine receptor 3C	0	1	0	1
Transporter	0	1	0	1
polyadenylate-binding protein 1	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Aldo-keto reductase family 1 member B1	0	1	0	1
Macrophage migration inhibitory factor	0	1	0	1
Solute carrier organic anion transporter family member 1A4	0	1	0	2
Solute carrier organic anion transporter family member 2B1	0	6	0	7
Solute carrier organic anion transporter family member 1A1	0	1	0	2
Solute carrier family 22 member 7	0	1	0	3
Solute carrier family 22 member 7	0	1	0	3
luciferase	0	0	0	1
Glucocorticoid receptor	0	1	1	2
Glucocorticoid receptor	0	0	1	1
Corticosteroid-binding globulin	0	1	0	1
Mineralocorticoid receptor	0	2	1	3
Glutamine synthetase	0	0	1	1
Nociceptin receptor	0	0	1	1
Glutamate 5-kinase	0	0	0	1
Angiotensin-converting enzyme	0	1	0	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Fatty-acid amide hydrolase 1	0	1	0	1
UDP-glucuronosyltransferase 1A9	0	0	0	1
UDP-glucuronosyltransferase 1A8	0	0	0	1
Pyridoxal kinase	0	0	0	1
dual specificity protein phosphatase 3	0	1	0	1
low molecular weight phosphotyrosine protein phosphatase isoform c	0	1	0	1
tyrosine-protein phosphatase non-receptor type 22 isoform 1	0	1	0	1
cGMP-dependent 3',5'-cyclic phosphodiesterase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Beta-hexosaminidase subunit alpha	0	1	0	2
Beta-hexosaminidase subunit beta	0	1	0	1
Substance-K receptor	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Low molecular weight phosphotyrosine protein phosphatase	0	1	0	1
Dipeptidyl peptidase 4	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Trace amine-associated receptor 5	0	0	1	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	2	0	2
Multidrug and toxin extrusion protein 1	0	1	0	1
N	0	1	0	1
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	1	0	0	1
cystic fibrosis transmembrane conductance regulator	0	1	0	1
DNA-directed RNA polymerase subunit alpha	0	1	0	1
DNA-directed RNA polymerase subunit omega	0	1	0	1
DNA-directed RNA polymerase subunit beta'	0	1	0	1
DNA-directed RNA polymerase subunit beta	0	1	0	1
Phospholipase A2, membrane associated	0	1	0	1
Phospholipase A2, membrane associated	0	1	0	1
Acidic phospholipase A2 2	0	1	0	1
Cholinesterase	0	1	0	1
2,3-bisphosphoglycerate-independent phosphoglycerate mutase	1	0	0	1
Chain A, PLASMA RETINOL-BINDING PROTEIN PRECURSOR	0	0	1	1
Retinol-binding protein 4	0	0	1	1
Beta-lactoglobulin	0	0	1	1
NS5	0	0	2	2
glycogen synthase kinase-3 beta isoform 1	0	0	1	1
Polymerase basic protein 2	0	0	1	1
RNA-directed RNA polymerase catalytic subunit	0	0	1	1
Polymerase acidic protein	0	0	2	2
Adenosylhomocysteinase	0	0	0	2
Adenosine receptor A1	0	1	0	1
Genome polyprotein	0	0	1	1
Chain A, 6,7-Dimethyl-8-ribityllumazine Synthase	0	0	1	1
Chain B, 6,7-Dimethyl-8-ribityllumazine Synthase	0	0	1	1
Chain A, Breast cancer type 1 susceptibility protein	1	0	0	1
Chain H, Immunoglobulin Igg1 Heavy chain	0	0	1	1
Chain L, Immunoglobulin Igg1 Lambda Light Chain	0	0	1	1
Chain A, DODECIN	0	0	1	1
Chain A, DODECIN	0	0	1	1
Chain C, DODECIN	0	0	1	1
Chain E, DODECIN	0	0	1	1
tumor necrosis factor	1	0	0	1
nuclear factor NF-kappa-B p105 subunit isoform 1	1	0	0	1
60 kDa chaperonin	0	1	0	1
60 kDa heat shock protein, mitochondrial	0	2	0	2
10 kDa heat shock protein, mitochondrial	0	2	0	2
Thiosulfate sulfurtransferase	0	2	0	2
DNA-directed RNA polymerase subunit beta	0	1	0	1
NH(3)-dependent NAD(+) synthetase	0	1	0	1
Solute carrier organic anion transporter family member 1A2	0	1	0	1
Glutathione S-transferase omega-1	0	1	0	1
DNA-directed RNA polymerase subunit beta	0	1	0	1
Chain A, HIV-1 PROTEASE	0	1	0	1
Chain B, HIV-1 PROTEASE	0	1	0	1
Chain A, Endothiapepsin	0	1	0	1
Chain A, Endothiapepsin	0	1	0	1
Gag-Pol polyprotein	0	1	0	1
Plasmepsin V	0	1	0	1
Estrogen receptor beta	0	0	0	1
Inhibitor of nuclear factor kappa-B kinase subunit beta	0	0	0	1
5'-AMP-activated protein kinase subunit beta-2	0	0	0	1
Tyrosine-protein phosphatase YopH	0	1	0	1
Prolyl 4-hydroxylase subunit alpha-1	0	1	0	1
Estrogen receptor	0	0	0	1
Cystathionine gamma-lyase	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-1	0	0	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-2	0	0	0	1
Xanthine dehydrogenase/oxidase	0	1	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-1	0	0	0	1
Carbonic anhydrase	0	1	0	1
Ubiquitin-like domain-containing CTD phosphatase 1	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-3	0	0	0	1
5'-AMP-activated protein kinase subunit gamma-2	0	0	0	1
5'-AMP-activated protein kinase subunit beta-1	0	0	0	1
photoreceptor-specific nuclear receptor	0	1	0	1
3-hydroxy-3-methylglutaryl-coenzyme A reductase	0	1	0	1
Cereblon isoform 4	0	3	0	3
RNA-directed RNA polymerase	0	0	1	2
Protein cereblon	0	4	1	6
Thymidine kinase 2	0	1	0	1
exodeoxyribonuclease V subunit RecD	0	1	0	1
exodeoxyribonuclease V subunit RecB	0	1	0	1
exodeoxyribonuclease V subunit RecC	0	1	0	1
Thymidine kinase, cytosolic	0	1	0	2
Peptidyl-prolyl cis-trans isomerase FKBP1A	0	2	1	3
Peptidyl-prolyl cis-trans isomerase FKBP1B	0	0	1	1
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	0	2	0	2
Peptidyl-prolyl cis-trans isomerase FKBP5	0	1	0	1
Splicing factor 3B subunit 3	0	1	0	1
Chain A, CES1 protein	0	1	0	1
DNA polymerase III, partial	1	0	0	1
interferon gamma precursor	0	0	0	1
ubiquitin-conjugating enzyme E2 N	0	1	0	1
Serine/threonine-protein kinase D3	0	1	0	1
Lysosomal acid glucosylceramidase	0	0	1	1
Protein kinase C gamma type	0	1	0	1
Protein kinase C alpha type	0	1	0	1
Protein kinase C beta type	0	2	0	2
Protein kinase C delta type	0	1	0	1
Protein kinase C epsilon type	0	1	0	1
Protein kinase C zeta type	0	1	0	1
Steroid hormone receptor ERR1	0	1	0	1
Transcriptional activator protein LuxR	0	1	0	1
Beta-3 adrenergic receptor	0	2	0	2
Protein kinase C alpha type	0	1	0	1
Protein kinase C eta type	0	1	0	1
Substance-P receptor	0	2	0	2
B2 bradykinin receptor	0	2	0	2
C-8 sterol isomerase	0	1	0	1
Protein kinase C iota type	0	1	0	1
Protein kinase C gamma type	0	1	0	1
Protein kinase C beta type	0	1	0	1
Phospholipase D1	0	1	0	1
Protein kinase C epsilon type	0	2	0	2
Protein kinase C theta type	0	1	0	1
Protein kinase C zeta type	0	1	0	1
Protein kinase C delta type	0	1	0	1
Platelet-activating factor acetylhydrolase	0	1	0	1
Phospholipase D1	0	1	0	1
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase	0	2	1	3
Serine/threonine-protein kinase D1	0	1	0	1
Protein kinase C eta type	0	1	0	1
Emopamil-binding protein-like	0	1	0	1
7-dehydrocholesterol reductase	0	1	1	2
Protein kinase C theta type	0	1	0	1
Adenylate kinase isoenzyme 1	0	0	0	1
Adenylate kinase 2, mitochondrial	0	0	0	1
90-kda heat shock protein beta HSP90 beta, partial	0	1	0	1
estrogen receptor beta isoform 1	0	1	0	1
tyrosine-protein phosphatase non-receptor type 7 isoform 2	0	1	0	1
Dihydroxyacetone phosphate acyltransferase	0	0	0	1
30S ribosomal protein S6	0	1	0	1
30S ribosomal protein S7	0	1	0	1
50S ribosomal protein L15	0	1	0	1
Tetracycline resistance protein, class B	0	0	0	1
72 kDa type IV collagenase	0	1	0	1
50S ribosomal protein L10	0	1	0	1
50S ribosomal protein L11	0	1	0	1
50S ribosomal protein L7/L12	0	1	0	1
50S ribosomal protein L19	0	1	0	1
50S ribosomal protein L1	0	1	0	1
50S ribosomal protein L20	0	1	0	1
50S ribosomal protein L27	0	1	0	1
50S ribosomal protein L28	0	1	0	1
50S ribosomal protein L29	0	1	0	1
50S ribosomal protein L31	0	1	0	1
50S ribosomal protein L31 type B	0	1	0	1
50S ribosomal protein L32	0	1	0	1
50S ribosomal protein L33	0	1	0	1
50S ribosomal protein L34	0	1	0	1
50S ribosomal protein L35	0	1	0	1
50S ribosomal protein L36	0	1	0	1
30S ribosomal protein S10	0	1	0	1
30S ribosomal protein S11	0	1	0	1
30S ribosomal protein S12	0	1	0	1
30S ribosomal protein S13	0	1	0	1
30S ribosomal protein S16	0	1	0	1
30S ribosomal protein S18	0	1	0	1
30S ribosomal protein S19	0	1	0	1
30S ribosomal protein S20	0	1	0	1
30S ribosomal protein S2	0	1	0	1
30S ribosomal protein S3	0	1	0	1
30S ribosomal protein S4	0	1	0	1
30S ribosomal protein S5	0	1	0	1
30S ribosomal protein S8	0	1	0	1
30S ribosomal protein S9	0	1	0	1
50S ribosomal protein L13	0	1	0	1
50S ribosomal protein L14	0	1	0	1
50S ribosomal protein L16	0	1	0	1
50S ribosomal protein L23	0	1	0	1
30S ribosomal protein S15	0	1	0	1
Multidrug transporter MdfA	0	1	0	1
50S ribosomal protein L17	0	1	0	1
50S ribosomal protein L21	0	1	0	1
50S ribosomal protein L30	0	1	0	1
50S ribosomal protein L6	0	1	0	1
30S ribosomal protein S14	0	1	0	1
30S ribosomal protein S17	0	1	0	1
30S ribosomal protein S1	0	1	0	1
50S ribosomal protein L18	0	1	0	1
Neutrophil collagenase	0	1	0	1
Collagenase 3	0	1	0	1
Cannabinoid receptor 1	0	1	0	1
50S ribosomal protein L2	0	1	0	1
50S ribosomal protein L3	0	1	0	1
50S ribosomal protein L24	0	1	0	1
50S ribosomal protein L4	0	1	0	1
50S ribosomal protein L22	0	1	0	1
50S ribosomal protein L5	0	1	0	1
30S ribosomal protein S21	0	1	0	1
50S ribosomal protein L25	0	1	0	1
50S ribosomal protein L36 2	0	1	0	1
P2Y purinoceptor 12	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4C	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
DNA-binding protein Ikaros	0	0	0	1
DNA damage-binding protein 1	0	1	1	2
Chain A, Protein (hiv-1 Protease)	0	1	0	1
Chain B, Protein (hiv-1 Protease)	0	1	0	1
Chain A, protease	0	0	1	1
Chain B, protease	0	0	1	1
Chain A, protease	0	0	1	1
Chain B, protease	0	0	1	1
Chain A, protease	0	0	1	1
Chain B, protease	0	0	1	1
Chain A, protease	0	0	1	1
Chain B, protease	0	0	1	1
Chain A, protease	0	0	1	1
Chain B, protease	0	0	1	1
Cathepsin D	0	1	0	1
Pepsin A-5	0	1	0	1
Cathepsin E	0	1	0	1
CAAX prenyl protease 1 homolog	0	1	0	1
Chain A, Trp Rna-binding Attenuation Protein	0	0	1	1
Chain K, Trp Rna-binding Attenuation Protein	0	0	1	1
Chain B, tryptophanyl-tRNA synthetase	0	0	1	1
Chain C, Tryptophanyl-tRNA synthetase II	0	0	1	1
Indoleamine 2,3-dioxygenase 1	0	1	0	2
Tryptophan 2,3-dioxygenase	0	1	0	2
SLC16A10 protein	0	0	0	2
Tryprostatin B synthase	0	0	0	1
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	0	0	1	1
Monocarboxylate transporter 10	0	0	0	2
Chain A, CHORISMATE MUTASE	0	1	0	1
Chain A, TYROSYL-tRNA SYNTHETASE	0	0	1	1
Tubulin--tyrosine ligase	0	1	0	1
Taste receptor type 2 member 14	0	0	0	1
Chain A, orotidine 5'-monophosphate decarboxylase	0	1	0	1
Chain B, orotidine 5'-monophosphate decarboxylase	0	1	0	1
Chain A, orotidine 5'-monophosphate decarboxylase	0	1	0	1
Chain A, orotidine monophosphate decarboxylase	0	1	0	1
Chain A, orotidine monophosphate decarboxylase	0	1	0	1
Chain B, orotidine monophosphate decarboxylase	0	1	0	1
Chain B, PyrR bifunctional protein	0	0	1	1
Orotidine 5'-phosphate decarboxylase	0	1	0	1
Uridine 5'-monophosphate synthase	0	1	0	1
UMP-CMP kinase	0	0	0	1
Orotidine 5'-phosphate decarboxylase	0	1	0	1
Protein argonaute-2	0	0	1	1
Sterol 14-alpha-demethylase	0	0	1	1
14-alpha sterol demethylase	0	0	1	1
Cholesterol side-chain cleavage enzyme, mitochondrial	0	0	1	1
14-alpha sterol demethylase	0	0	1	1
Cholesterol 24-hydroxylase	0	2	1	3
pyruvate kinase PKM isoform a	1	0	0	1
tyrosine-protein kinase Yes	1	0	0	1
Ectonucleoside triphosphate diphosphohydrolase 1	0	0	0	1
DNA polymerase beta	0	1	0	1
Thymidylate kinase	0	1	0	1
Thymidine kinase	0	1	0	2
Thymidine kinase	0	1	0	2
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(1)

Research Excerpts

Overview

Context

Research

Studies (315)

Protein Targets (1,342)

Porphyria Cutanea Tarda

Synonyms(1)

Research Excerpts

Overview

Context

Research

Studies (315)

Drugs Studied (186)

Protein Targets (1,342)