ascorbic-acid and Psychotic-Disorders

Topics: Amino Acids; Ascorbic Acid; Dihydroxyphenylalanine; Humans; Methionine; Niacinamide; Nicotinic Acids; Phenylalanine; Psychotic Disorders; Pyridoxine; Schizophrenia; Tryptophan; Tyrosine

Topics: Antidepressive Agents; Ascorbic Acid; Clinical Trials as Topic; Depression; Drug Combinations; Drug Evaluation; Humans; Magnesium; Middle Aged; Psychotic Disorders; Vitamin A; Vitamin B Complex; Vitamin E; Xanthines

Low levels of vitamin C have been observed in patients with schizophrenia and psychosis, and vitamin C may affect the dopaminergic system. Likewise, antipsychotic medication modulates striatal dopamine D2 receptors. We measured vitamin C levels in 52 patients with first-episode psychoses (24 females, age 23.1 ± 5.2 years) and 57 matched HCs (20 females, age 22.7 ± 4.3 years) before and after 6 weeks where patients received aripiprazole monotherapy (mean dose 10.4 mg ± 4.8 mg). At baseline, patients displayed lower levels of vitamin C (57.4 ± 25.9 µM) than controls (72.7 ± 21.4 µM) (t = 3.4, P = .001). Baseline symptoms and vitamin C levels were not correlated. Higher baseline vitamin C levels were associated with more improvement in negative symptoms (n = 39, R2 = 0.20, F = 8.2, P = .007), but not with age, sex, or p-aripiprazole. Because negative symptoms are generally considered challenging to alleviate, a potential adjunctive effect of vitamin C on treatment response should be tested in future randomized clinical trials.

Topics: Adolescent; Adult; Antipsychotic Agents; Aripiprazole; Ascorbic Acid; Female; Humans; Psychotic Disorders; Schizophrenia; Young Adult

Topics: Aged; Ascorbic Acid; Ascorbic Acid Deficiency; Female; Humans; Obsessive-Compulsive Disorder; Psychotic Disorders

Increasing evidence indicates that oxidative injury exists in schizophrenia. Although it may not be the main cause, oxidative damage has been suggested to contribute to the pathophysiology and may account for deteriorating course and poor outcome in schizophrenia. A human study was undertaken, therefore, to investigate possible differences in biomarkers of DNA, lipid and protein oxidation in schizophrenic (n=16) and control subjects (n=17). Plasma vitamin C levels were also compared in both groups. Cellular DNA damage and plasma protein carbonyl levels were increased in the schizophrenic group compared to control subjects but not significantly. However, DNA damage in lymphocytes from the male schizophrenic group was significantly higher than the female group. Biomarkers of lipid peroxidation and plasma vitamin C levels also revealed no significant difference between the two groups under investigation, although a significant elevation in plasma vitamin C was observed in the female control group when compared to the male groups.

Topics: Adult; Antipsychotic Agents; Ascorbic Acid; Biomarkers; Case-Control Studies; Cells, Cultured; Cryopreservation; DNA Damage; Female; Humans; Hydrogen Peroxide; Lipid Peroxidation; Lymphocytes; Male; Middle Aged; Oxidative Stress; Protein Carbonylation; Psychotic Disorders

Nutritional deficiency may be a presenting sign of undiagnosed psychiatric illness. In this case, we present a patient with scurvy as a complication of fixed psychotic delusions regarding his diet. Dermatologists may play a crucial role in the recognition of psychiatric illnesses and appropriate referral for care.

Topics: Ascorbic Acid; Diet; Humans; Male; Middle Aged; Psychotic Disorders; Scurvy

Plasma vitamin C was measured in 885 patients in a psychiatric hospital and in 110 healthy controls. The average value was lower in the patients (0.51 mg/100 ml) than in the controls (0.87 mg/100 ml). Length of stay in hospital had little effect on plasma vitamin C in the patients, but the values were marginally lower in males, females on iron therapy and in those with senile dementia. In the patients, many of whom had been offered a similar diet for several years, age was not associated with a change in plasma vitamin C and this suggests that changes in vitamin C with age that have been reported reflect differences in intake. Few patients had values as low as those found in clinical scurvy (less than 0.1 mg/100 ml), but many (32 per cent) had concentrations below the threshold (0.35 mg/100 ml) at which some detrimental effects on health have been reported.

Topics: Affective Disorders, Psychotic; Age Factors; Aged; Ascorbic Acid; Chlorpromazine; Dementia; Female; Hospitals, Psychiatric; Humans; Iron; Length of Stay; Male; Middle Aged; Psychotic Disorders; Schizophrenia; Sex Factors

The recent upsurge in megavitamin therapy raises questions about the role of vitamin deficiencies and dependencies in mental health. With this in mind, the plasma levels of folic acid, ascorbic acid, pyridoxine, and riboflavin were studied in approximately 125 children admitted to a child psychiatric unit. There were no apparent decreased levels of vitamins in these children in terms of their age, race, or psychiatric diagnosis. It is postulated that vitamin deficiencies per se cannot be proposed as etiological factors in any of the psychiatric deficits represented. Megavitamin therapy, if successful, is not effective due to crrection of vitamin deficiencies as opposed to vitamin dependencies and may be due to the metabolic onus and consequent effects of such heavy doses of vitamins.

Topics: Adolescent; Affective Symptoms; Ascorbic Acid; Autistic Disorder; Child; Child Behavior Disorders; Child, Preschool; Folic Acid; Humans; Intellectual Disability; Male; Orthomolecular Therapy; Psychotic Disorders; Pyridoxine; Riboflavin; Schizophrenia

Serum ascorbic acid concentrations, taken from 37 chronically hospitalized psychiatric patients, were found to be similar to those usually encountered in normal subjects.

Topics: Ascorbic Acid; Chronic Disease; Humans; Psychotic Disorders; Time Factors

Topics: Adolescent; Ascorbic Acid; Brain Diseases; Electroencephalography; Emaciation; Female; Humans; Psychotic Disorders; Puberty; Pyridoxine; Riboflavin; Thiamine; Vitamin B 12

Topics: Ascorbic Acid; Brain; Brain Damage, Chronic; Carcinoma, Bronchogenic; Dementia; Diagnosis, Differential; Drug Therapy; Geriatrics; Humans; Niacin; Psychotic Disorders; Schizophrenia; Urine

Topics: Ascorbic Acid; Confusion; Female; Humans; Mental Disorders; Pregnancy; Psychotic Disorders; Puerperal Disorders

Topics: Ascorbic Acid; Benzaldehydes; Central Nervous System Stimulants; Delirium; Folic Acid; Fructose; Humans; Prednisolone; Psychoses, Alcoholic; Psychotic Disorders; Pyridoxine; Rutin; Sorbitol; Vitamin B 12; Vitamin B Complex; Vitamin K 1

Topics: 17-Ketosteroids; Addison Disease; Adrenal Cortex Hormones; Adrenal Glands; Adrenal Insufficiency; Adrenocorticotropic Hormone; Ascorbic Acid; Blood Chemical Analysis; Eosinophils; Hypoadrenocorticism, Familial; Injections, Intramuscular; Nephritis; Pharmacology; Prednisolone; Psychotic Disorders; Urine

Topics: Alcohol Withdrawal Delirium; Ascorbic Acid; Humans; Mental Disorders; Psychoses, Alcoholic; Psychotic Disorders; Vitamin B Complex; Vitamin K; Vitamins

Topics: Ascorbic Acid; Dementia; Female; Humans; Mental Disorders; Postpartum Period; Psychotic Disorders

Topics: Ascorbic Acid; Electricity; Exercise; Humans; Mental Disorders; Oxidoreductases; Psychotic Disorders; Schizophrenia; Vitamins

Topics: Aniline Compounds; Ascorbic Acid; Coloring Agents; Phenylenediamines; Psychotic Disorders; Schizophrenia

Topics: Adenosine Triphosphate; Animals; Ascorbic Acid; Biochemical Phenomena; Brain; Lysergic Acid Diethylamide; Neurochemistry; Psychoses, Substance-Induced; Psychotic Disorders; Rabbits; Vitamins

Topics: Ascorbic Acid; Dementia; Humans; Psychotic Disorders; Vitamin A; Vitamin K; Vitamins

Topics: Adenosine Triphosphate; Animals; Ascorbic Acid; Biochemical Phenomena; Brain; Cyanides; Cytochromes; Cytochromes c; Neurochemistry; Psychotic Disorders; Rabbits; Stupor

Topics: Adrenocorticotropic Hormone; Ascorbic Acid; Cortisone; Humans; Neurotic Disorders; Psychiatry; Psychotic Disorders; Vitamins

Topics: Adrenal Cortex Hormones; Ascorbic Acid; Desoxycorticosterone; Psychiatry; Psychotic Disorders; Vitamins

Topics: Adrenal Cortex Hormones; Ascorbic Acid; Mental Disorders; Psychotic Disorders; Vitamins