nemorosone profile

Flora	Rank	Flora Definition	Family	Family Definition
Clusia	genus	A plant genus of the family CLUSIACEAE. Members contain benzophenones.[MeSH]	Clusiaceae	The mangosteen plant family (sometimes classified as Guttiferae; also known as Hypericaceae) of the order THEALES, subclass Dilleniidae, class Magnoliopsida. It includes trees and shrubs with resinous, sticky sap, usually with broad-ended, oblong, leathery leaves with a strong, central vein, flowers with many stamens.[MeSH]

ID Source	ID
PubMed CID	637105
CHEMBL ID	583445
SCHEMBL ID	14524547
SCHEMBL ID	14524549
MeSH ID	M0402563

Synonym
inchi=1/c33h42o4/c1-21(2)14-16-25-20-32(19-18-23(5)6)28(35)26(17-15-22(3)4)29(36)33(30(32)37,31(25,7)8)27(34)24-12-10-9-11-13-24/h9-15,18,25,35h,16-17,19-20h2,1-8h3/t25-,32+,33-/m0/s
1-benzoyl-4-hydroxy-8,8-dimethyl-3,5,7-tris-(3-methyl-but-2-enyl)-bicyclo[3.3.1]non-3-ene-2,9-dione
bicyclo[3.3.1]non-3-ene-2,9-dione, 1-benzoyl-4-hydroxy-8,8-dimethyl-3,5,7-tris(3-methyl-2-butenyl)-, (1r,5r,7s)-
rel-(1r,5r,7s)-1-benzoyl-4-hydroxy-8,8-dimethyl-3,5,7-tris(3-methylbut-2-en-1-yl)bicyclo[3.3.1]non-3-ene-2,9-dione
1-benzoyl-3,5,7-tri-(3-methyl-2-butenyl)-4-hydroxy-8-dimethyl-bicyclo[3.3.1]-3-nonene-2,9-dione
nemorosone ,
CHEMBL583445
SCHEMBL14524547
SCHEMBL14524549
memorosone
(1r,5r,7s)-1-benzoyl-4-hydroxy-8,8-dimethyl-3,5,7-tris(3-methylbut-2-enyl)bicyclo[3.3.1]non-3-ene-2,9-dione
(1r,5s,7s)-rel-5-benzoyl-4-hydroxy-6,6-dimethyl-1,3,7-tris(3-methyl-2-buten-1-yl)-bicyclo[3.3.1]non-3-ene-2,9-dione
351416-47-2
HY-121458
CS-0082127
AKOS040755542

Excerpt	Reference	Relevance
"Nemorosone is a bicyclic polyprenylated acylphloroglucinol derivative originally isolated from Clusia spp. "	( A review of nemorosone: Chemistry and biological properties. Cuesta-Rubio, O; Fernández-Acosta, R; Monzote, L; Pardo-Andreu, GL; Rastrelli, L, 2023)	2.73
"Nemorosone is a polycyclic polyisoprenylated benzophenone (PPBs) with strong cytotoxic activity. "	( Fragmentation pathways of polycyclic polyisoprenylated benzophenones and degradation profile of nemorosone by multiple-stage tandem mass spectrometry. Campone, L; Cuesta-Rubio, O; Dal Piaz, F; Piccinelli, AL; Rastrelli, L, 2009)	2.01

Excerpt	Reference	Relevance
"Nemorosone has both cytostatic and cytotoxic activity and it also seems to induce apoptosis and ferroptosis."	( A review of nemorosone: Chemistry and biological properties. Cuesta-Rubio, O; Fernández-Acosta, R; Monzote, L; Pardo-Andreu, GL; Rastrelli, L, 2023)	2.01
"Nemorosone has received increasing attention due to its strong in vitro anti-cancer action."	( Evaluation of estrogenic, antiestrogenic and genotoxic activity of nemorosone, the major compound found in brown Cuban propolis. Boldrin, PK; Camargo, MS; Cardoso, CR; Cuesta-Rubio, O; Fernández, MF; Molina-Molina, JM; Olea, N; Prieto, AM; Resende, FA; Varanda, EA; Vilegas, W, 2013)	1.35

Excerpt	Reference	Relevance
" Thus, we investigated the growth-inhibitory potential of nemorosone on pancreatic cancer xenografts in NMRI nu/nu mice and determined basic pharmacokinetic parameters."	( In vivo activity and pharmacokinetics of nemorosone on pancreatic cancer xenografts. Hilger, RA; Hoheisel, JD; Holtrup, F; Werner, J; Wolf, RJ, 2013)	0.9

Bioassays (31)

Assay ID	Title	Year	Journal	Article
AID345139	Cytotoxicity against human HT-29 cells after 24 hrs	2008	Bioorganic & medicinal chemistry, Nov-15, Volume: 16, Issue:22	The contribution of plukenetione A to the anti-tumoral activity of Cuban propolis.
AID345143	Cytotoxicity against SN38-resistant human HCT8 cells after 24 hrs	2008	Bioorganic & medicinal chemistry, Nov-15, Volume: 16, Issue:22	The contribution of plukenetione A to the anti-tumoral activity of Cuban propolis.
AID345165	Cytotoxicity against Swiss mouse 3T3 cells after 24 hrs	2008	Bioorganic & medicinal chemistry, Nov-15, Volume: 16, Issue:22	The contribution of plukenetione A to the anti-tumoral activity of Cuban propolis.
AID345156	Cytotoxicity against 5-FU-resistant human LAN1 cells after 24 hrs	2008	Bioorganic & medicinal chemistry, Nov-15, Volume: 16, Issue:22	The contribution of plukenetione A to the anti-tumoral activity of Cuban propolis.
AID345148	Cytotoxicity against human A2780 cells after 24 hrs	2008	Bioorganic & medicinal chemistry, Nov-15, Volume: 16, Issue:22	The contribution of plukenetione A to the anti-tumoral activity of Cuban propolis.
AID345164	Cytotoxicity against human MCR5 cells after 24 hrs	2008	Bioorganic & medicinal chemistry, Nov-15, Volume: 16, Issue:22	The contribution of plukenetione A to the anti-tumoral activity of Cuban propolis.
AID345159	Cytotoxicity against etoposide-resistant human LNCAP cells after 24 hrs	2008	Bioorganic & medicinal chemistry, Nov-15, Volume: 16, Issue:22	The contribution of plukenetione A to the anti-tumoral activity of Cuban propolis.
AID345149	Cytotoxicity against doxorubicin-resistant human A2780 cells after 24 hrs	2008	Bioorganic & medicinal chemistry, Nov-15, Volume: 16, Issue:22	The contribution of plukenetione A to the anti-tumoral activity of Cuban propolis.
AID345158	Cytotoxicity against human LNCAP cells after 24 hrs	2008	Bioorganic & medicinal chemistry, Nov-15, Volume: 16, Issue:22	The contribution of plukenetione A to the anti-tumoral activity of Cuban propolis.
AID345144	Cytotoxicity against raltitrexed-resistant human HCT8 cells after 24 hrs	2008	Bioorganic & medicinal chemistry, Nov-15, Volume: 16, Issue:22	The contribution of plukenetione A to the anti-tumoral activity of Cuban propolis.
AID683842	Cytotoxicity against human MIAPaCa2 cells after 72 hrs by resazurin assay	2012	Bioorganic & medicinal chemistry letters, Oct-01, Volume: 22, Issue:19	Comparison of the cytotoxic effects of enantiopure PPAPs, including nemorosone and clusianone.
AID345151	Cytotoxicity against human M51 cells after 24 hrs	2008	Bioorganic & medicinal chemistry, Nov-15, Volume: 16, Issue:22	The contribution of plukenetione A to the anti-tumoral activity of Cuban propolis.
AID345155	Cytotoxicity against cisplatin-resistant human LAN1 cells after 24 hrs	2008	Bioorganic & medicinal chemistry, Nov-15, Volume: 16, Issue:22	The contribution of plukenetione A to the anti-tumoral activity of Cuban propolis.
AID345161	Cytotoxicity against human K562 cells after 24 hrs	2008	Bioorganic & medicinal chemistry, Nov-15, Volume: 16, Issue:22	The contribution of plukenetione A to the anti-tumoral activity of Cuban propolis.
AID345162	Cytotoxicity against human H460 cells after 24 hrs	2008	Bioorganic & medicinal chemistry, Nov-15, Volume: 16, Issue:22	The contribution of plukenetione A to the anti-tumoral activity of Cuban propolis.
AID447340	Cytotoxicity against human HeLa cells after 24 to 48 hrs by MTT assay	2009	Bioorganic & medicinal chemistry, Jul-15, Volume: 17, Issue:14	Identification of a bioactive compound isolated from Brazilian propolis type 6.
AID345420	Cytotoxicity against human Jurkat cells after 24 hrs	2008	Bioorganic & medicinal chemistry, Nov-15, Volume: 16, Issue:22	The contribution of plukenetione A to the anti-tumoral activity of Cuban propolis.
AID345145	Cytotoxicity against human MCF7 cells after 24 hrs	2008	Bioorganic & medicinal chemistry, Nov-15, Volume: 16, Issue:22	The contribution of plukenetione A to the anti-tumoral activity of Cuban propolis.
AID345157	Cytotoxicity against human PC3 cells after 24 hrs	2008	Bioorganic & medicinal chemistry, Nov-15, Volume: 16, Issue:22	The contribution of plukenetione A to the anti-tumoral activity of Cuban propolis.
AID683840	Cytotoxicity against human HeLa cells after 72 hrs by resazurin assay	2012	Bioorganic & medicinal chemistry letters, Oct-01, Volume: 22, Issue:19	Comparison of the cytotoxic effects of enantiopure PPAPs, including nemorosone and clusianone.
AID345154	Cytotoxicity against etoposide-resistant human LAN1 cells after 24 hrs	2008	Bioorganic & medicinal chemistry, Nov-15, Volume: 16, Issue:22	The contribution of plukenetione A to the anti-tumoral activity of Cuban propolis.
AID345147	Cytotoxicity against 5-FU-resistant human MCF7 cells after 24 hrs	2008	Bioorganic & medicinal chemistry, Nov-15, Volume: 16, Issue:22	The contribution of plukenetione A to the anti-tumoral activity of Cuban propolis.
AID345153	Cytotoxicity against human LAN1 cells after 24 hrs	2008	Bioorganic & medicinal chemistry, Nov-15, Volume: 16, Issue:22	The contribution of plukenetione A to the anti-tumoral activity of Cuban propolis.
AID345150	Cytotoxicity against cisplatin-resistant human A2780 cells after 24 hrs	2008	Bioorganic & medicinal chemistry, Nov-15, Volume: 16, Issue:22	The contribution of plukenetione A to the anti-tumoral activity of Cuban propolis.
AID683841	Cytotoxicity against human MCF7 cells after 72 hrs by resazurin assay	2012	Bioorganic & medicinal chemistry letters, Oct-01, Volume: 22, Issue:19	Comparison of the cytotoxic effects of enantiopure PPAPs, including nemorosone and clusianone.
AID345141	Cytotoxicity against SN38-resistant human HT-29 cells after 24 hrs	2008	Bioorganic & medicinal chemistry, Nov-15, Volume: 16, Issue:22	The contribution of plukenetione A to the anti-tumoral activity of Cuban propolis.
AID345140	Cytotoxicity against 5-FU-resistant human HT-29 cells after 24 hrs	2008	Bioorganic & medicinal chemistry, Nov-15, Volume: 16, Issue:22	The contribution of plukenetione A to the anti-tumoral activity of Cuban propolis.
AID345152	Cytotoxicity against cisplatin-resistant human M51 cells after 24 hrs	2008	Bioorganic & medicinal chemistry, Nov-15, Volume: 16, Issue:22	The contribution of plukenetione A to the anti-tumoral activity of Cuban propolis.
AID345163	Cytotoxicity against HEK293 cells after 24 hrs	2008	Bioorganic & medicinal chemistry, Nov-15, Volume: 16, Issue:22	The contribution of plukenetione A to the anti-tumoral activity of Cuban propolis.
AID345142	Cytotoxicity against human HCT8 cells after 24 hrs	2008	Bioorganic & medicinal chemistry, Nov-15, Volume: 16, Issue:22	The contribution of plukenetione A to the anti-tumoral activity of Cuban propolis.
AID345146	Cytotoxicity against doxorubicin-resistant human MCF7 cells after 24 hrs	2008	Bioorganic & medicinal chemistry, Nov-15, Volume: 16, Issue:22	The contribution of plukenetione A to the anti-tumoral activity of Cuban propolis.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	10 (26.32)	29.6817
2010's	23 (60.53)	24.3611
2020's	5 (13.16)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	2 (5.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	38 (95.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
phloroglucinol Phloroglucinol: A trinitrobenzene derivative with antispasmodic properties that is used primarily as a laboratory reagent.. phloroglucinol : A benzenetriol with hydroxy groups at position 1, 3 and 5.	3.47	7	benzenetriol; phenolic donor	algal metabolite
niacinamide nicotinamide : A pyridinecarboxamide that is pyridine in which the hydrogen at position 3 is replaced by a carboxamide group.	2.08	1	pyridine alkaloid; pyridinecarboxamide; vitamin B3	anti-inflammatory agent; antioxidant; cofactor; EC 2.4.2.30 (NAD(+) ADP-ribosyltransferase) inhibitor; EC 3.5.1.98 (histone deacetylase) inhibitor; Escherichia coli metabolite; geroprotector; human urinary metabolite; metabolite; mouse metabolite; neuroprotective agent; Saccharomyces cerevisiae metabolite; Sir2 inhibitor
fluorouracil Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.. 5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.	2.04	1	nucleobase analogue; organofluorine compound	antimetabolite; antineoplastic agent; environmental contaminant; immunosuppressive agent; radiosensitizing agent; xenobiotic
catechin Catechin: An antioxidant flavonoid, occurring especially in woody plants as both (+)-catechin and (-)-epicatechin (cis) forms.. catechin : Members of the class of hydroxyflavan that have a flavan-3-ol skeleton and its substituted derivatives.. rac-catechin : A racemate comprising equimolar amounts of (+)- and (-)-catechin. (+)-catechin : The (+)-enantiomer of catechin and a polyphenolic antioxidant plant metabolite.	2.08	1	catechin	antioxidant; plant metabolite
pyrazines Pyrazines: A heterocyclic aromatic organic compound with the chemical formula C4H4N2.. pyrazine : A diazine that is benzene in which the carbon atoms at positions 1 and 4 have been replaced by nitrogen atoms.	2.08	1	diazine; pyrazines	Daphnia magna metabolite
oleanolic acid [no description available]	2.01	1	hydroxy monocarboxylic acid; pentacyclic triterpenoid	plant metabolite
deoxycytidine [no description available]	2.08	1	pyrimidine 2'-deoxyribonucleoside	Escherichia coli metabolite; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite
gold Gold: A yellow metallic element with the atomic symbol Au, atomic number 79, and atomic weight 197. It is used in jewelry, goldplating of other metals, as currency, and in dental restoration. Many of its clinical applications, such as ANTIRHEUMATIC AGENTS, are in the form of its salts.	7.1	1	copper group element atom; elemental gold
gemcitabine gemcitabine : A 2'-deoxycytidine having geminal fluoro substituents in the 2'-position. An inhibitor of ribonucleotide reductase, gemcitabine is used in the treatment of various carcinomas, particularly non-small cell lung cancer, pancreatic cancer, bladder cancer and breast cancer.	2.48	2	organofluorine compound; pyrimidine 2'-deoxyribonucleoside	antimetabolite; antineoplastic agent; antiviral drug; DNA synthesis inhibitor; EC 1.17.4.1 (ribonucleoside-diphosphate reductase) inhibitor; environmental contaminant; immunosuppressive agent; photosensitizing agent; prodrug; radiosensitizing agent; xenobiotic
sorafenib [no description available]	2.08	1	(trifluoromethyl)benzenes; aromatic ether; monochlorobenzenes; phenylureas; pyridinecarboxamide	angiogenesis inhibitor; anticoronaviral agent; antineoplastic agent; EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor; ferroptosis inducer; tyrosine kinase inhibitor
bortezomib [no description available]	2.08	1	amino acid amide; L-phenylalanine derivative; pyrazines	antineoplastic agent; antiprotozoal drug; protease inhibitor; proteasome inhibitor
hyperforin hyperforin: a prenylated acylphloroglucinol derivative; antibiotic component of novoimanine; psychoactive agent in St. John's wort; Russian; structure;. hyperforin : A cyclic terpene ketone that is a prenylated carbobicyclic acylphloroglucinol derivative produced by St. John's Wort, Hypericum perforatum.	7.75	3
mucronulatol mucronulatol: compound from Caribbean propolis that exerts cytotoxic effects on human tumor cell lines. mucronulatol : A methoxyisoflavan that is (S)-isoflavan substituted by methoxy groups at positions 2' and 4' and hydroxy groups at positions 7 and 3' respectively.	2.04	1	hydroxyisoflavans; methoxyisoflavan	antineoplastic agent; plant metabolite
glycosides [no description available]	2.13	1
tamoxifen [no description available]	3.13	1	stilbenoid; tertiary amino compound	angiogenesis inhibitor; antineoplastic agent; bone density conservation agent; EC 1.2.3.1 (aldehyde oxidase) inhibitor; EC 2.7.11.13 (protein kinase C) inhibitor; estrogen antagonist; estrogen receptor antagonist; estrogen receptor modulator
1,1-diphenyl-2-picrylhydrazyl 1,1-diphenyl-2-picrylhydrazyl: A diphenyl picrate; the ability to decolorize this stable radical indicates reactivity of tested compounds (Banda, Anal Chem 46:1772-7 1974)	2.13	1
lithium Lithium: An element in the alkali metals family. It has the atomic symbol Li, atomic number 3, and atomic weight [6.938; 6.997]. Salts of lithium are used in treating BIPOLAR DISORDER.	7.08	1	alkali metal atom
luteolin [no description available]	2.6	1	3'-hydroxyflavonoid; tetrahydroxyflavone	angiogenesis inhibitor; anti-inflammatory agent; antineoplastic agent; apoptosis inducer; c-Jun N-terminal kinase inhibitor; EC 2.3.1.85 (fatty acid synthase) inhibitor; immunomodulator; nephroprotective agent; plant metabolite; radical scavenger; vascular endothelial growth factor receptor antagonist
garcinol garcinol: from stem bark of Garcinia huillensis; has chemotherapeutic activity against gram-positive & gram-negative cocci, mycobacteria & fungi	2.13	1
3,4-di-o-caffeoylquinic acid 3,4-di-O-caffeoylquinic acid: isolated from Siphonostegia chinensis	2.6	1	quinic acid
goserelin Goserelin: A synthetic long-acting agonist of GONADOTROPIN-RELEASING HORMONE. Goserelin is used in treatments of malignant NEOPLASMS of the prostate, uterine fibromas, and metastatic breast cancer.	3.13	1	organic molecular entity
guttiferone a guttiferone A: antibacterial from Clusiaceae family; structure in first source	2.49	2
7-epiclusianone 7-epiclusianone: from Rheedia gardneriana; structure in first source. 7-epiclusianone : An enone that is a tetraprenyl benzophenone derivative isolated from Rheedia gardneriana and Garcinia brasiliensis. It exhibits anti-allergic, antibacterial, trypanocidal and vasodilating activities.	2.98	4
polonium Polonium: A radioactive element that is a member of the chalcogen family. It has the atomic symbol Po, atomic number 84, and the atomic weight of the isotope with the longest half-life (209Po) is 208.98. It decays by alpha-emission.. polonium atom : A radioactive metallic element discovered in 1898 by Marie Sklodowska Curie and named after her home country, Poland (Latin Polonia).	2.01	1	chalcogen; metal atom
garsubellin a garsubellin A: from wood of Garcinia subelliptica; structure given in first source	2.08	1
morelloflavone morelloflavone: also inhibits cruzain; RN given for (2S-trans)-isomer; structure in first source. (+)-morelloflavone : A biflavonoid found in Rheedia edulis and Garcinia livingstonei.	2.13	1	biflavonoid; hydroxyflavanone; hydroxyflavone	plant metabolite
nad NAD(1-) : An anionic form of nicotinamide adenine dinucleotide arising from deprotonation of the two OH groups of the diphosphate moiety.	2.1	1	organophosphate oxoanion	cofactor; human metabolite; hydrogen acceptor; Saccharomyces cerevisiae metabolite
cytochrome c-t Cytochromes c: Cytochromes of the c type that are found in eukaryotic MITOCHONDRIA. They serve as redox intermediates that accept electrons from MITOCHONDRIAL ELECTRON TRANSPORT COMPLEX III and transfer them to MITOCHONDRIAL ELECTRON TRANSPORT COMPLEX IV.	2.06	1
plukenetione a plukenetione A: produced by honey bees from various plant sources; structure in first source	7.45	2
ascorbic acid Ascorbic Acid: A six carbon compound related to glucose. It is found naturally in citrus fruits and many vegetables. Ascorbic acid is an essential nutrient in human diets, and necessary to maintain connective tissue and bone. Its biologically active form, vitamin C, functions as a reducing agent and coenzyme in several metabolic pathways. Vitamin C is considered an antioxidant.. L-ascorbic acid : The L-enantiomer of ascorbic acid and conjugate acid of L-ascorbate.. L-ascorbate : The L-enantiomer of ascorbate and conjugate base of L-ascorbic acid, arising from selective deprotonation of the 3-hydroxy group. Required for a range of essential metabolic reactions in all animals and plants.. vitamin C : Any member of a group of vitamers that belong to the chemical structural class called butenolides that exhibit biological activity against vitamin C deficiency in animals. The vitamers include L-ascorbic acid and its salt, ionized and oxidized forms.	2.13	1	ascorbic acid; vitamin C	coenzyme; cofactor; flour treatment agent; food antioxidant; food colour retention agent; geroprotector; plant metabolite; skin lightening agent

Condition	Relationship Strength	Studies
Acute Confusional Senile Dementia [description not available]	2.6	1
Alzheimer Disease A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)	2.6	1
Benign Neoplasms [description not available]	2.6	1
Neoplasms New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.	2.6	1
Breast Cancer [description not available]	4.4	4
Breast Neoplasms Tumors or cancer of the human BREAST.	4.4	4
Hepatocellular Carcinoma [description not available]	7.21	1
Cancer of Liver [description not available]	2.21	1
Carcinoma, Hepatocellular A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.	2.21	1
Liver Neoplasms Tumors or cancer of the LIVER.	2.21	1
Colorectal Cancer [description not available]	7.25	1
Invasiveness, Neoplasm [description not available]	2.66	2
Colorectal Neoplasms Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI.	2.25	1
Cancer of Colon [description not available]	2.21	1
Colonic Neoplasms Tumors or cancer of the COLON.	2.21	1
Carcinoma, Anaplastic [description not available]	2.48	2
Cancer of Pancreas [description not available]	2.48	2
Carcinoma A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It is a histological type of neoplasm and not a synonym for cancer.	7.48	2
Pancreatic Neoplasms Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).	2.48	2
Leucocythaemia [description not available]	2.04	1
Leukemia A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. Leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular maturity. Acute leukemias consist of predominately immature cells; chronic leukemias are composed of more mature cells. (From The Merck Manual, 2006)	7.04	1
Malignant Melanoma [description not available]	2.08	1
Conjunctival Neoplasms Tumors or cancer of the CONJUNCTIVA.	2.08	1
Melanoma A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)	2.08	1
Cancer of Prostate [description not available]	2.07	1
Prostatic Neoplasms Tumors or cancer of the PROSTATE.	2.07	1
Menopause The last menstrual period. Permanent cessation of menses (MENSTRUATION) is usually defined after 6 to 12 months of AMENORRHEA in a woman over 45 years of age. In the United States, menopause generally occurs in women between 48 and 55 years of age.	2.95	1
Neuroblastoma A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)	7.04	1

nemorosone

Cross-References

Synonyms (16)

Research Excerpts

Overview

Effects

Pharmacokinetics

Bioassays (31)

Research

Studies (38)

Market Indicators

Research Demand Index: 20.39

Study Types

nemorosone

Related Flora

Cross-References

Synonyms (16)

Research Excerpts

Overview

Effects

Pharmacokinetics

Bioassays (31)

Research

Studies (38)

Market Indicators

Research Demand Index: 20.39

Study Types

Related Drugs (30)

Related Conditions (28)