citrate anion : A tricarboxylic acid anion obtained by deprotonation of at least one of the carboxy groups of citric acid. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]
citrate(3-) : A tricarboxylic acid trianion, obtained by deprotonation of the three carboxy groups of citric acid. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]
| ID Source | ID |
|---|---|
| PubMed CID | 31348 |
| CHEBI ID | 16947 |
| MeSH ID | M0066232 |
| Synonym |
|---|
| 126-44-3 |
| 2-hydroxypropane-1,2,3-tricarboxylate |
| CHEBI:16947 |
| cit(3-) |
| citrate(3-) |
| 2-hydroxy-1,2,3-propanetricarboxylate(3-) |
| 2-hydroxy-1,2,3-propanetricarboxylic acid, ion(3-) |
| citrate ion |
| citrate anion |
| citrate |
| NCGC00164253-02 |
| 2-oxidanylpropane-1,2,3-tricarboxylate |
| A839293 |
| 1,2,3-propanetricarboxylic acid, 2-hydroxy-, ion(3-) |
| unii-664cch53pi |
| 664cch53pi , |
| bdbm92494 |
| FT-0622333 |
| STL264199 |
| AKOS022140114 |
| 3RY8 |
| 4EU3 |
| 3KGQ |
| 3ITC |
| 2YG2 |
| 3R69 |
| 2QPQ |
| KRKNYBCHXYNGOX-UHFFFAOYSA-K |
| AB00443858_02 |
| DTXSID30155037 |
| citrate trianion |
| citric acid, ion(3-) |
| Q55503059 |
| citrate(3-) anion |
| NCGC00164253-04 |
| anionstandard-citrate |
| Role | Description |
|---|---|
| fundamental metabolite | Any metabolite produced by all living cells. |
| [role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Class | Description |
|---|---|
| tricarboxylic acid trianion | |
| citrate anion | A tricarboxylic acid anion obtained by deprotonation of at least one of the carboxy groups of citric acid. |
| [compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Protein | Taxonomy | Measurement | Average (µ) | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Spike glycoprotein | Severe acute respiratory syndrome-related coronavirus | Potency | 14.1254 | 0.0096 | 10.5250 | 35.4813 | AID1479145 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Chain A, Apolipoprotein M | Homo sapiens (human) | IC50 (µMol) | 0.9000 | 0.9000 | 0.9000 | 0.9000 | AID977608 |
| Chain A, renal dipeptidase | Streptomyces coelicolor | Ki | 25,000.0000 | 25,000.0000 | 25,000.0000 | 25,000.0000 | AID977610 |
| Chain A, Dipeptidase | Streptomyces coelicolor | Ki | 25,000.0000 | 25,000.0000 | 25,000.0000 | 25,000.0000 | AID977610 |
| Chain B, Succinyl-CoA:acetate coenzyme A transferase | Acetobacter aceti | Ki | 150,000.0000 | 150,000.0000 | 150,000.0000 | 150,000.0000 | AID977610 |
| Carbonic anhydrase | Flaveria bidentis | Ki | 41.4000 | 0.0270 | 0.0270 | 0.0270 | AID1803442 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Chain A, protein Bug27 | Bordetella pertussis | Kd | 0.4300 | 0.4300 | 0.4300 | 0.4300 | AID977611 |
| Chain B, Na(+)/H(+) exchange regulatory cofactor NHE-RF3, Scavenger receptor class B member 1 | Mus musculus (house mouse) | Kd | 37.0000 | 37.0000 | 37.0000 | 37.0000 | AID977611 |
| Chain A, Capsid protein | Norwalk virus | Kd | 460.0000 | 460.0000 | 460.0000 | 460.0000 | AID977611 |
| Chain B, Capsid protein | Norwalk virus | Kd | 460.0000 | 460.0000 | 460.0000 | 460.0000 | AID977611 |
| Methyl-accepting chemotaxis protein NahY | Pseudomonas putida | Kd | 109.0000 | 8.5000 | 8.5000 | 8.5000 | AID1799787 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Process | via Protein(s) | Taxonomy |
|---|---|---|
| virion membrane | Spike glycoprotein | Severe acute respiratory syndrome-related coronavirus |
| [Information is prepared from geneontology information from the June-17-2024 release] | ||
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID977610 | Experimentally measured binding affinity data (Ki) for protein-ligand complexes derived from PDB | 2012 | Biochemistry, Oct-23, Volume: 51, Issue:42 | Crystal structures of Acetobacter aceti succinyl-coenzyme A (CoA):acetate CoA-transferase reveal specificity determinants and illustrate the mechanism used by class I CoA-transferases. |
| AID977611 | Experimentally measured binding affinity data (Kd) for protein-ligand complexes derived from PDB | 2011 | The Journal of biological chemistry, Jul-15, Volume: 286, Issue:28 | Identification of the PDZ3 domain of the adaptor protein PDZK1 as a second, physiologically functional binding site for the C terminus of the high density lipoprotein receptor scavenger receptor class B type I. |
| AID977608 | Experimentally measured binding affinity data (IC50) for protein-ligand complexes derived from PDB | 2011 | Proceedings of the National Academy of Sciences of the United States of America, Jun-07, Volume: 108, Issue:23 | Endothelium-protective sphingosine-1-phosphate provided by HDL-associated apolipoprotein M. |
| AID977611 | Experimentally measured binding affinity data (Kd) for protein-ligand complexes derived from PDB | 2007 | Journal of molecular biology, Nov-02, Volume: 373, Issue:4 | Structure-based mechanism of ligand binding for periplasmic solute-binding protein of the Bug family. |
| AID1803442 | Stopped Flow CO2 Hydration Assay from Article 10.3109/14756366.2013.813942: \\Biochemical characterization of the chloroplastic u00DF-carbonic anhydrase from Flaveria bidentis (L.) "Kuntze".\\ | 2014 | Journal of enzyme inhibition and medicinal chemistry, Aug, Volume: 29, Issue:4 | Biochemical characterization of the chloroplastic β-carbonic anhydrase from Flaveria bidentis (L.) "Kuntze". |
| AID1799787 | Isothermal Titration Calorimetry from Article 10.1074/jbc.M110.110403: \\Identification of a chemoreceptor for tricarboxylic acid cycle intermediates: differential chemotactic response towards receptor ligands.\\ | 2010 | The Journal of biological chemistry, Jul-23, Volume: 285, Issue:30 | Identification of a chemoreceptor for tricarboxylic acid cycle intermediates: differential chemotactic response towards receptor ligands. |
| AID977611 | Experimentally measured binding affinity data (Kd) for protein-ligand complexes derived from PDB | 2012 | Journal of virology, Jan, Volume: 86, Issue:1 | Structural basis for norovirus inhibition and fucose mimicry by citrate. |
| AID977610 | Experimentally measured binding affinity data (Ki) for protein-ligand complexes derived from PDB | 2010 | Biochemistry, Jan-26, Volume: 49, Issue:3 | Structure, mechanism, and substrate profile for Sco3058: the closest bacterial homologue to human renal dipeptidase . |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (12.50) | 29.6817 |
| 2010's | 7 (87.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be very strong demand-to-supply ratio for research on this compound.
| This Compound (55.75) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 8 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||