Compounds > serum p-component
Page last updated: 2024-12-06

serum p-component

Description

citrate anion : A tricarboxylic acid anion obtained by deprotonation of at least one of the carboxy groups of citric acid. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

citrate(3-) : A tricarboxylic acid trianion, obtained by deprotonation of the three carboxy groups of citric acid. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID31348
CHEBI ID16947
MeSH IDM0066232

Synonyms (36)

Synonym
126-44-3
2-hydroxypropane-1,2,3-tricarboxylate
CHEBI:16947
cit(3-)
citrate(3-)
2-hydroxy-1,2,3-propanetricarboxylate(3-)
2-hydroxy-1,2,3-propanetricarboxylic acid, ion(3-)
citrate ion
citrate anion
citrate
NCGC00164253-02
2-oxidanylpropane-1,2,3-tricarboxylate
A839293
1,2,3-propanetricarboxylic acid, 2-hydroxy-, ion(3-)
unii-664cch53pi
664cch53pi ,
bdbm92494
FT-0622333
STL264199
AKOS022140114
3RY8
4EU3
3KGQ
3ITC
2YG2
3R69
2QPQ
KRKNYBCHXYNGOX-UHFFFAOYSA-K
AB00443858_02
DTXSID30155037
citrate trianion
citric acid, ion(3-)
Q55503059
citrate(3-) anion
NCGC00164253-04
anionstandard-citrate
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Occurs in Manufacturing (34 Product(s))

Product Categories

Product CategoryProducts
Professional Supplements1
Vitamins & Supplements30
Household Essentials1
Active Lifestyle & Fitness2

Products

ProductBrandCategoryCompounds Matched from IngredientsDate Retrieved
Amy Myers MD OsteoDura -- 120 CapsulesAmy Myers MDProfessional Supplementscarbonate, Vitamin D3, citrate, citrate, phytonadione, Vitamin K2024-11-29 10:47:42
Baywood International Cal-Mag Fizz Lemon Lime -- 17.4 ozBaywood InternationalVitamins & SupplementsNiacin, Pantothenic Acid, Vitamin B6, Riboflavin, Selenium, citrate, citrate, Thiamin, Vitamin B12, Vitamin B62024-11-29 10:47:42
Bio Nutrition Blood Pressure Wellness -- 60 TabletsBio NutritionVitamins & SupplementsVitamin D3, Coenzyme Q10, citrate, citrate2024-11-29 10:47:42
Bluebonnet Nutrition Calcium Magnesium 1:1 Ratio -- 180 Vegetable CapsulesBluebonnet NutritionVitamins & Supplementscitrate, citrate2024-11-29 10:47:42
Bluebonnet Nutrition EarthSweet Chewables Calcium Magnesium & Vitamin D3 Natural Vanilla -- 90 Chewable TabletsBluebonnet NutritionVitamins & Supplementscarbonate, Vitamin D3, citrate, citrate2024-11-29 10:47:42
Bluebonnet Nutrition Maxi ONE® Whole Food-Based Multiple -- 90 Vegetable CapsulesBluebonnet NutritionVitamins & SupplementsVitamin C, Biotin, Boron, Vitamin D3, Choline, Chromium, Vitamin E, riboflavin 5' phosphate, Folate, Vitamin E, Iodine, Manganese, Molybdenum, Vitamin B3, Pantothenic Acid, pyridoxine 5' phosphate, pyridoxine HCl, Vitamin B6, Vitamin A, Vitamin B2, Selenium, citrate, citrate, Vitamin B1, Vitamin B12, Vitamin B6, Vitamin K2024-11-29 10:47:42
Bluebonnet Nutrition Multiminerals & Boron Iron-Free -- 180 Vegetable CapsulesBluebonnet NutritionVitamins & SupplementsBoron, carbonate, Chromium, Iodine, Manganese, Molybdenum, Selenium, citrate, citrate2024-11-29 10:47:42
Bluebonnet Nutrition Super Earth Rainforest Animalz Calcium Magnesium & Vitamin D3 Natural Vanilla Frosting -- 90 ChewablesBluebonnet NutritionVitamins & Supplementscarbonate, Vitamin D3, citrate, citrate2024-11-29 10:47:42
Bluebonnet Nutrition Triple Boron -- 90 Vegetable CapsulesBluebonnet NutritionVitamins & SupplementsBoron, citrate, citrate2024-11-29 10:47:42
Country Life Bone Solid® -- 240 CapsulesCountry LifeVitamins & Supplements alpha-ketoglutarate, Vitamin C, calcium ascorbate, Calcium Fructoborate, Chromium, Manganese, Phosphorus, citrate, citrate, tricalcium phosphate, Vitamin K2024-11-29 10:47:42
Country Life Calcium-Magnesium with Vitamin D Complex -- 240 Vegan CapsulesCountry LifeVitamins & Supplements alpha-ketoglutarate, calcium citrate, Phosphorus, citrate, citrate2024-11-29 10:47:42
Country Life Calcium-Magnesium with Vitamin D Complex -- 360 Vegan CapsulesCountry LifeVitamins & Supplements alpha-ketoglutarate, calcium citrate, Phosphorus, citrate, citrate2024-11-29 10:47:42
Country Life Calcium-Magnesium-Potassium -- 180 TabletsCountry LifeVitamins & Supplements asparatate, Phosphorus, potassium citrate, citrate, citrate2024-11-29 10:47:42
Country Life Core Daily-1 for Men 50 + -- 60 TabletsCountry LifeVitamins & SupplementsLipase, Vitamin C, beta carotene, Betaine, Biotin, Calcium fructoborate, d-calcium pantothenate, Cellulase, Choline, Chromium, Vitamin E, riboflavin 5' phosphate, Folic Acid, Vitamin E, inositol hexanicotinate, Inositol, Lactose, Manganese, Molybdenum, Niacin, pantethine, Pantothenic Acid, Phosphorus, pyridoxal 5' phosphate, pyridoxine hydrochloride, Vitamin B6, Vitamin A, Riboflavin, Selenium, citrate, citrate, thiamine hydrochloride, Thiamin, cyanocobalamin, Vitamin B6, Vitamin K2024-11-29 10:47:42
Country Life Core Daily™ 1 for Women 50 Plus -- 60 TabletsCountry LifeVitamins & SupplementsLipase, Vitamin C, beta carotene, Betaine, Biotin, Calcium fructoborate, d-calcium pantothenate, Cellulase, Choline, Chromium, Vitamin E, riboflavin 5' phosphate, Folic Acid, Vitamin E, inositol hexanicotinate, Inositol, Lactose, Manganese, Molybdenum, Niacin, pantethine, Pantothenic Acid, Phosphorus, pyridoxal 5' phosphate, pyridoxine hydrochloride, Vitamin B6, Vitamin A, Riboflavin, Selenium, citrate, citrate, thiamine hydrochloride, Thiamin, cyanocobalamin, Vitamin B6, Vitamin K2024-11-29 10:47:42
Country Life Target-Mins Calcium Magnesium Complex with Vitamin D3 -- 90 TabletsCountry LifeVitamins & Supplements alpha-ketoglutarate, Vitamin D3, Phosphorus, citrate, citrate2024-11-29 10:47:42
Deva Vegan Cal-Mag Plus -- 90 TabletsDevaVitamins & SupplementsVitamin C, Boron, calcium carbonate, citrate, citrate, Vitamin D2, Vitamin K2024-11-29 10:47:42
Ecover Ecological Toilet Bowl Cleaner -- 25 fl ozEcoverHousehold Essentialscitric acid, citric acid, pine, citrate, citrate2024-11-29 10:47:42
Futurebiotics Pressur-Lo® -- 270 TabletsFuturebioticsVitamins & SupplementsVitamin C, Betaine HCl, Chloride, Chromium, CoQ10, calcium carbonate, Manganese, Niacin, Pantothenic Acid, potassium chloride, Vitamin B6, Resveratrol, Vitamin A, Riboflavin, Rutin, Selenium, citrate, citrate, L-Taurine, Thiamin, Vitamin B12, Vitamin B62024-11-29 10:47:42
Futurebiotics Pressur-Lo™ -- 90 TabletsFuturebioticsVitamins & SupplementsVitamin C, Betaine HCl, Chloride, Chromium, CoQ10, calcium carbonate, Manganese, Niacin, Pantothenic Acid, potassium chloride, Vitamin B6, Vitamin A, Riboflavin, Rutin, Selenium, citrate, citrate, L-Taurine, Thiamin, Vitamin B12, Vitamin B62024-11-29 10:47:42
Harmonic Innerprizes Calcium from the Sea -- 180 Veggie CapsHarmonic InnerprizesVitamins & SupplementsLipase, Vitamin C, Cellulase, Vitamin D3, Iodine, Vitamin K2, Vitamin K2, citrate, citrate2024-11-29 10:47:42
Igennus Triple Magnesium Complex -Citrate & Fully Chelated Bisglycinate & Taurate Vegan -- 60 TabletsIgennusVitamins & Supplementscitrate, citrate2024-11-29 10:47:42
Life Extension Magnesium Caps -- 500 mg - 100 Vegetarian CapsulesLife ExtensionVitamins & Supplementsmicrocrystalline cellulose, citrate, stearic acid, citrate2024-11-29 10:47:42
Optimum Nutrition Opti-Women Multivitamin for Women -- 120 CapsulesOptimum NutritionActive Lifestyle & FitnessAlpha-Carotene, Vitamin C, kelp, Biotin, Chromium, Cryptoxanthin, Vitamin E, Folate, Vitamin E, microcrystalline cellulose, Iodine, Isoflavone, calcium carbonate, Lutein, Lycopene, Manganese, Molybdenum, Niacin, Pantothenic Acid, Vitamin B6, vitamin A palmitate, Vitamin A, Riboflavin, Selenium, citrate, sodium selenate, citrate, Thiamin, Alpha-Lipoic Acid, calcium phosphate, Vitamin B12, Vitamin B6, Vitamin K, Zeaxanthin2024-11-29 10:47:42
Optimum Nutrition Opti-Women Multivitamin for Women -- 60 CapsulesOptimum NutritionActive Lifestyle & FitnessAlpha-Carotene, Vitamin C, kelp, Biotin, Chromium, Cryptoxanthin, Vitamin E, Folic Acid, Vitamin E, microcrystalline cellulose, Iodine, calcium carbonate, Lutein, Lycopene, Manganese, Molybdenum, Niacin, Pantothenic Acid, potassium iodide, Vitamin B6, Vitamin A, Riboflavin, Selenium, citrate, citrate, Thiamin, Alpha-Lipoic Acid, Vitamin B12, Vitamin B6, Vitamin K, Zeaxanthin2024-11-29 10:47:42
Phyto Therapy Liquid Calcium with Magnesium -- 1000 mg (Calcium) - 400 mg (Magnesium) - 180 SoftgelsPhyto TherapyVitamins & SupplementsBoron, dicalcium phosphate, Vitamin D3, gluconate, glycerin, maltodextrin, citrate, sorbitol, citrate, titanium dioxide, Vitamin K12024-11-29 10:47:42
Phyto Therapy Liquid Calcium with Magnesium -- 1000 mg (Calcium) - 400 mg (Magnesium) - 90 SoftgelsPhyto TherapyVitamins & SupplementsBoron, dicalcium phosphate, Vitamin D3, gluconate, glycerin, maltodextrin, citrate, sorbitol, citrate, titanium dioxide, Vitamin K12024-11-29 10:47:42
Phyto Therapy Vegetarian Calcium with Magnesium -- 180 VegeCapsPhyto TherapyVitamins & SupplementsBoron, Vitamin D3, gluconate, maltodextrin, citrate, citrate, Vitamin K12024-11-29 10:47:42
Snap Supplements Kidney Health -- 60 CapsulesSnap SupplementsVitamins & SupplementsL-5-MTHF, Vitamin C, chloride, Folate, Vitamin B3, niacinamide, Pantothenic Acid, Vitamin B2, citrate, citrate, Vitamin B1, Vitamin B122024-11-29 10:47:42
Trace Minerals Research Liquid Magnesium Natural Tangerine -- 300 mg - 16 fl ozTrace Minerals ResearchVitamins & Supplementscitric acid, Chloride, citric acid, Citrate, Citrate, xylitol2024-11-29 10:47:42
Vitanica Adrenal Assist™ -- 90 Vegetarian CapsulesVitanicaVitamins & SupplementsVitamin B5, Vitamin B6, citrate, citrate, Vitamin B62024-11-29 10:47:42
Vitanica Luminous® Hair Skin & Nails Support -- 60 Vegetarian CapsulesVitanicaVitamins & SupplementsVitamin C, Biotin, calcium ascorbate, Vitamin E, Vitamin E, Selenium, citrate, citrate, Vitamin D22024-11-29 10:47:42
Vitanica SleepBlend™ -- 60 Vegetarian CapsulesVitanicaVitamins & Supplements5-Hydroxy tryptophan, Melatonin, Vitamin B6, Riboflavin, citrate, citrate, Vitamin B12, Vitamin B62024-11-29 10:47:42
World Organic Cal-Mag Zinc Liquid Supplement -- 16 fl ozWorld OrganicVitamins & Supplements Chloride, Vitamin D3, Gluconate, Magnesium Carbonate, cethylose, Phosphorus, Potassium Citrate, Citrate, sorbitol, Citrate, Tricalcium Phosphate2024-11-29 10:47:42

Roles (1)

RoleDescription
fundamental metaboliteAny metabolite produced by all living cells.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (2)

ClassDescription
tricarboxylic acid trianion
citrate anionA tricarboxylic acid anion obtained by deprotonation of at least one of the carboxy groups of citric acid.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Pathways (85)

PathwayProteinsCompounds
acetyl-CoA biosynthesis from citrate07
TCA cycle III (animals)023
glycolysis IV (plant cytosol)1347
TCA cycle II (plants and fungi)1419
medicarpin conjugates interconversion015
acetyl-CoA biosynthesis III (from citrate)07
superpathway of cytosolic glycolysis (plants), pyruvate dehydrogenase and TCA cycle2856
superpathway of acetyl-CoA biosynthesis112
genistein conjugates interconversion016
daidzein conjugates interconversion016
TCA cycle variation V (plant)1422
biochanin A conjugates interconversion016
glyoxylate cycle813
superpathway of formononetin derivative biosynthesis031
maackiain conjugates interconversion015
superpathway of glyoxylate cycle and fatty acid degradation2529
formononetin conjugates interconversion014
Rubisco shunt632
superpathway of anaerobic sucrose degradation3360
LPS and Citrate Signaling and Inflammation2311
L-glutamine biosynthesis III725
reductive TCA cycle I025
Amino acid metabolism in triple-negative breast cancer cells016
Metabolic Epileptic Disorders2589
superpathway of conversion of glucose to acetyl CoA and entry into the TCA cycle4737
acetyl-CoA biosynthesis from citrate17
TCA cycle1724
L-tyrosine biosynthesis I616
acetyl-CoA biosynthesis III (from citrate)37
superpathway of acetyl-CoA biosynthesis212
superpathway of cytosolic glycolysis (plants), pyruvate dehydrogenase and TCA cycle2459
glyoxylate cycle1336
superpathway of glyoxylate cycle and fatty acid degradation2625
superpathway of glycolysis and the Entner-Doudoroff pathway2358
Rubisco shunt832
superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass3989
methylaspartate cycle1035
hydrogen oxidation I (aerobic)58
TCA cycle I (prokaryotic)1741
TCA cycle VII (acetate-producers)219
photosynthetic 3-hydroxybutanoate biosynthesis (engineered)6373
TCA cycle II (plants and fungi)2422
TCA cycle III (animals)1724
partial TCA cycle (obligate autotrophs)026
TCA cycle VIII (helicobacter)1319
biochanin A conjugates interconversion017
maackiain conjugates interconversion017
TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase)1233
daidzein conjugates interconversion017
superpathway of L-phenylalanine biosynthesis1665
formononetin conjugates interconversion016
TCA cycle IV (2-oxoglutarate decarboxylase)221
genistein conjugates interconversion017
L-phenylalanine biosynthesis I628
medicarpin conjugates interconversion017
D-galactarate degradation I530
L-glutamate degradation II223
superpathway of microbial D-galacturonate and D-glucuronate degradation3592
reductive TCA cycle I327
superpathway of nicotinate degradation1254
reductive TCA cycle II1024
mixed acid fermentation3276
acinetoferrin biosynthesis414
superpathway of N-acetylneuraminate degradation3979
rhizobactin 1021 biosynthesis622
citrate degradation55
achromobactin biosynthesis217
staphyloferrin A biosynthesis39
nicotinate degradation III1241
1,3-propanediol biosynthesis (engineered)1535
aerobactin biosynthesis417
staphyloferrin B biosynthesis720
baumannoferrin biosynthesis620
gluconeogenesis I2862
superpathway of hexitol degradation (bacteria)2960
superpathway of L-aspartate and L-asparagine biosynthesis730
superpathway of aromatic amino acid biosynthesis2184
glycolysis II (from fructose 6-phosphate)2149
glycolysis I (from glucose 6-phosphate)3751
glycolysis V (Pyrococcus)730
glycolysis IV (plant cytosol)747
glycogen biosynthesis III (from u03B1-maltose 1-phosphate)818
superpathway of L-tyrosine biosynthesis1557
superpathway of chorismate metabolism56186
L-glutamate degradation X29
superpathway of D-glucarate and D-galactarate degradation637
superpathway of formononetin derivative biosynthesis234
superpathway of anaerobic sucrose degradation2661
superpathway of glyoxylate bypass and TCA1855
trehalose biosynthesis II111
trehalose biosynthesis I719
ethylene biosynthesis V (engineered)7842
TCA cycle variation V (plant)2325
superpathway of central carbon metabolism346
respiration (anaerobic)026
superpathway of glycolysis, pyruvate dehydrogenase and TCA cycle134
superpathway of glyoxylate cycle024
TCA cycle variation I719
TCA cycle variation II618
TCA cycle variation III (eukaryotic)1220
acetyl-CoA biosynthesis (from citrate)16
superpathway of glycolysis and TCA variant VIII033
TCA cycle VI (obligate autotrophs)027
glutamine biosynthesis III024
TCA cycle III (helicobacter)018

Protein Targets (11)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Spike glycoproteinSevere acute respiratory syndrome-related coronavirusPotency14.12540.009610.525035.4813AID1479145
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Chain A, Apolipoprotein MHomo sapiens (human)IC50 (µMol)0.90000.90000.90000.9000AID977608
Chain A, renal dipeptidaseStreptomyces coelicolorKi25,000.000025,000.000025,000.000025,000.0000AID977610
Chain A, DipeptidaseStreptomyces coelicolorKi25,000.000025,000.000025,000.000025,000.0000AID977610
Chain B, Succinyl-CoA:acetate coenzyme A transferaseAcetobacter acetiKi150,000.0000150,000.0000150,000.0000150,000.0000AID977610
Carbonic anhydraseFlaveria bidentisKi41.40000.02700.02700.0270AID1803442
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Activation Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Chain A, protein Bug27Bordetella pertussisKd0.43000.43000.43000.4300AID977611
Chain B, Na(+)/H(+) exchange regulatory cofactor NHE-RF3, Scavenger receptor class B member 1Mus musculus (house mouse)Kd37.000037.000037.000037.0000AID977611
Chain A, Capsid proteinNorwalk virusKd460.0000460.0000460.0000460.0000AID977611
Chain B, Capsid proteinNorwalk virusKd460.0000460.0000460.0000460.0000AID977611
Methyl-accepting chemotaxis protein NahYPseudomonas putidaKd109.00008.50008.50008.5000AID1799787
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Ceullar Components (1)

Processvia Protein(s)Taxonomy
virion membraneSpike glycoproteinSevere acute respiratory syndrome-related coronavirus
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (8)

Assay IDTitleYearJournalArticle
AID977610Experimentally measured binding affinity data (Ki) for protein-ligand complexes derived from PDB2012Biochemistry, Oct-23, Volume: 51, Issue:42
Crystal structures of Acetobacter aceti succinyl-coenzyme A (CoA):acetate CoA-transferase reveal specificity determinants and illustrate the mechanism used by class I CoA-transferases.
AID977611Experimentally measured binding affinity data (Kd) for protein-ligand complexes derived from PDB2011The Journal of biological chemistry, Jul-15, Volume: 286, Issue:28
Identification of the PDZ3 domain of the adaptor protein PDZK1 as a second, physiologically functional binding site for the C terminus of the high density lipoprotein receptor scavenger receptor class B type I.
AID977608Experimentally measured binding affinity data (IC50) for protein-ligand complexes derived from PDB2011Proceedings of the National Academy of Sciences of the United States of America, Jun-07, Volume: 108, Issue:23
Endothelium-protective sphingosine-1-phosphate provided by HDL-associated apolipoprotein M.
AID977611Experimentally measured binding affinity data (Kd) for protein-ligand complexes derived from PDB2007Journal of molecular biology, Nov-02, Volume: 373, Issue:4
Structure-based mechanism of ligand binding for periplasmic solute-binding protein of the Bug family.
AID1803442Stopped Flow CO2 Hydration Assay from Article 10.3109/14756366.2013.813942: \\Biochemical characterization of the chloroplastic u00DF-carbonic anhydrase from Flaveria bidentis (L.) "Kuntze".\\2014Journal of enzyme inhibition and medicinal chemistry, Aug, Volume: 29, Issue:4
Biochemical characterization of the chloroplastic β-carbonic anhydrase from Flaveria bidentis (L.) "Kuntze".
AID1799787Isothermal Titration Calorimetry from Article 10.1074/jbc.M110.110403: \\Identification of a chemoreceptor for tricarboxylic acid cycle intermediates: differential chemotactic response towards receptor ligands.\\2010The Journal of biological chemistry, Jul-23, Volume: 285, Issue:30
Identification of a chemoreceptor for tricarboxylic acid cycle intermediates: differential chemotactic response towards receptor ligands.
AID977611Experimentally measured binding affinity data (Kd) for protein-ligand complexes derived from PDB2012Journal of virology, Jan, Volume: 86, Issue:1
Structural basis for norovirus inhibition and fucose mimicry by citrate.
AID977610Experimentally measured binding affinity data (Ki) for protein-ligand complexes derived from PDB2010Biochemistry, Jan-26, Volume: 49, Issue:3
Structure, mechanism, and substrate profile for Sco3058: the closest bacterial homologue to human renal dipeptidase .
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (8)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (12.50)29.6817
2010's7 (87.50)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 55.75

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be very strong demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index55.75 (24.57)
Research Supply Index2.20 (2.92)
Research Growth Index4.66 (4.65)
Search Engine Demand Index83.58 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (55.75)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other8 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
butyric acid
Butyric Acid: A four carbon acid, CH3CH2CH2COOH, with an unpleasant odor that occurs in butter and animal fat as the glycerol ester.. butyrate : A short-chain fatty acid anion that is the conjugate base of butyric acid, obtained by deprotonation of the carboxy group.. butyric acid : A straight-chain saturated fatty acid that is butane in which one of the terminal methyl groups has been oxidised to a carboxy group.		2.0510fatty acid 4:0;
straight-chain saturated fatty acid		human urinary metabolite;
Mycoplasma genitalium metabolite
malic acid
malic acid : A 2-hydroxydicarboxylic acid that is succinic acid in which one of the hydrogens attached to a carbon is replaced by a hydroxy group.. 2-hydroxydicarboxylic acid : Any dicarboxylic acid carrying a hydroxy group on the carbon atom at position alpha to the carboxy group.		2.05102-hydroxydicarboxylic acid;
C4-dicarboxylic acid		food acidity regulator;
fundamental metabolite
oxaloacetic acid
Oxaloacetic Acid: A dicarboxylic acid ketone that is an important metabolic intermediate of the CITRIC ACID CYCLE. It can be converted to ASPARTIC ACID by ASPARTATE TRANSAMINASE.. oxaloacetic acid : An oxodicarboxylic acid that is succinic acid bearing a single oxo group.		2.0510C4-dicarboxylic acid;
oxo dicarboxylic acid		geroprotector;
metabolite
succinic acid
Succinic Acid: A water-soluble, colorless crystal with an acid taste that is used as a chemical intermediate, in medicine, the manufacture of lacquers, and to make perfume esters. It is also used in foods as a sequestrant, buffer, and a neutralizing agent. (Hawley's Condensed Chemical Dictionary, 12th ed, p1099; McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed, p1851). succinic acid : An alpha,omega-dicarboxylic acid resulting from the formal oxidation of each of the terminal methyl groups of butane to the corresponding carboxy group. It is an intermediate metabolite in the citric acid cycle.		2.0510alpha,omega-dicarboxylic acid;
C4-dicarboxylic acid		anti-ulcer drug;
fundamental metabolite;
micronutrient;
nutraceutical;
radiation protective agent
isocitric acid
isocitric acid: RN given refers to unlabeled parent cpd. isocitric acid : A tricarboxylic acid that is propan-1-ol with a hydrogen at each of the 3 carbon positions replaced by a carboxy group.		2.0510secondary alcohol;
tricarboxylic acid		fundamental metabolite
valerates
Valerates: Derivatives of valeric acid, including its salts and esters.		2.110short-chain fatty acid anion;
straight-chain saturated fatty acid anion		plant metabolite
fumaric acid
fumaric acid: see also record for ferrous fumarate; use FUMARATES for general fumaric acid esters. fumaric acid : A butenedioic acid in which the C=C double bond has E geometry. It is an intermediate metabolite in the citric acid cycle.		2.0510butenedioic acidfood acidity regulator;
fundamental metabolite;
geroprotector
ConditionIndicatedRelationship StrengthStudiesTrials
Gastroenteritis
INFLAMMATION of any segment of the GASTROINTESTINAL TRACT from ESOPHAGUS to RECTUM. Causes of gastroenteritis are many including genetic, infection, HYPERSENSITIVITY, drug effects, and CANCER.		02.0710
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