Synthetic or natural substance which is given to prevent a disease or disorder or are used in the process of treating a disease or injury due to a poisonous agent.
| Member | Definition | Class |
|---|
| 4-hydroxyphenylethanol | A phenol substituted at position 4 by a 2-hydroxyethyl group. | 2-(4-hydroxyphenyl)ethanol |
| alx-0600 | A 33-membered polypeptide consisting of His, Gly, Asp, Gly, Ser, Phe, Ser, Asp, Glu, Met, Asn, Thr, Ile, Leu, Asp, Asn, Leu, Ala, Ala, Arg, Asp, Phe, Ile, Asn, Trp, Leu, Ile, Gln, Thr, Lys, Ile, Thr and Asp residues joined in sequence. A glucagon-like peptide-2 receptor agonist used for the treatment of short-bowel syndrome. | teduglutide |
| benphothiamine | A thioester that is a synthetic analogue of thiamine obtained by acylative cleavage of the thiazole ring and O-phospohorylation. | benfotiamine |
| citrulline | The L-enantiomer of citrulline. | L-citrulline zwitterion; L-citrulline |
| deferiprone | A member of the class of 4-pyridones that is pyridin-4(1H)-one substituted at positions 1 and 2 by methyl groups and at position 3 by a hydroxy group. A lipid-soluble iron-chelator used for treatment of thalassaemia. | deferiprone |
| ferruginol | An abietane diterpenoid that is abieta-8,11,13-triene substituted by a hydroxy group at positions 12. | ferruginol |
| fomepizole | A member of the class of pyrazoles that is 1H-pyrazole substituted by a methyl group at position 4. | fomepizole |
| glycylglutamine | A dipeptide formed from glycine and L-glutamine residues. | Gly-Gln zwitterion; Gly-Gln |
| monodansylcadaverine | A sulfonamide obtained by formal condensation of the sulfo group of 5-(dimethylamino)naphthalene-1-sulfonic acid with one of the amino groups of cadaverine. | monodansylcadaverine |
| N-octylhomovanillamide | A monocarboxylic acid amide that is the N-octyl amide of homovanillic acid. | N-octylhomovanillamide |
| oltipraz | A 1,2-dithiole that is 3H-1,2-dithiole-3-thione substituted at positions 4 and 5 by methyl and pyrazin-2-yl groups respectively. | oltipraz |
| oxybenzone | A hydroxybenzophenone that is benzophenone which is substituted at the 2- and 4-positions of one of the benzene rings by hydroxy and methoxy groups respectively. | oxybenzone |
| phenylephrine | A member of the class of the class of phenylethanolamines that is (1R)-2-(methylamino)-1-phenylethan-1-ol carrying an additional hydroxy substituent at position 3 on the phenyl ring. | phenylephrine |
| tributyrin | A triglyceride obtained by formal acylation of the three hydroxy groups of glycerol by butyric acid. | tributyrin |
| zonisamide | A 1,2-benzoxazole compound having a sulfamoylmethyl substituent at the 3-position. | zonisamide |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| 15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1 | Homo sapiens (human) | Potency | 12.9623 | 1 | 3 |
| activating transcription factor 6 | Homo sapiens (human) | Potency | 0.1738 | 1 | 1 |
| aldehyde dehydrogenase 1 family, member A1 | Homo sapiens (human) | Potency | 34.3521 | 1 | 3 |
| apical membrane antigen 1, AMA1 | Plasmodium falciparum 3D7 | Potency | 19.9526 | 1 | 1 |
| AR protein | Homo sapiens (human) | Potency | 23.1284 | 5 | 12 |
| aryl hydrocarbon receptor | Homo sapiens (human) | Potency | 35.0760 | 2 | 6 |
| ATAD5 protein, partial | Homo sapiens (human) | Potency | 17.3582 | 2 | 2 |
| ATP-dependent phosphofructokinase | Trypanosoma brucei brucei TREU927 | Potency | 37.9330 | 1 | 1 |
| bromodomain adjacent to zinc finger domain 2B | Homo sapiens (human) | Potency | 54.6373 | 1 | 3 |
| Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 33.4915 | 1 | 1 |
| Chain A, 2-oxoglutarate Oxygenase | Homo sapiens (human) | Potency | 8.4279 | 1 | 2 |
| Chain A, JmjC domain-containing histone demethylation protein 3A | Homo sapiens (human) | Potency | 15.8489 | 1 | 1 |
| Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE | Homo sapiens (human) | Potency | 5.6234 | 1 | 1 |
| Chain A, Putative fructose-1,6-bisphosphate aldolase | Giardia intestinalis | Potency | 6.1904 | 1 | 2 |
| chromobox protein homolog 1 | Homo sapiens (human) | Potency | 94.5626 | 1 | 2 |
| cytochrome P450 2C19 precursor | Homo sapiens (human) | Potency | 1.7802 | 1 | 2 |
| cytochrome P450 2C9 precursor | Homo sapiens (human) | Potency | 2.5119 | 1 | 1 |
| cytochrome P450 2C9, partial | Homo sapiens (human) | Potency | 38.9018 | 1 | 1 |
| cytochrome P450 2D6 isoform 1 | Homo sapiens (human) | Potency | 12.5893 | 1 | 1 |
| cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a | Homo sapiens (human) | Potency | 10.4520 | 1 | 2 |
| D(1A) dopamine receptor | Homo sapiens (human) | Potency | 5.6234 | 1 | 1 |
| DNA polymerase kappa isoform 1 | Homo sapiens (human) | Potency | 15.8489 | 1 | 1 |
| dopamine D1 receptor | Homo sapiens (human) | Potency | 1.8356 | 1 | 1 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 29.8956 | 9 | 21 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 32.9767 | 6 | 17 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 10.2362 | 1 | 2 |
| EWS/FLI fusion protein | Homo sapiens (human) | Potency | 0.0288 | 4 | 5 |
| G | Vesicular stomatitis virus | Potency | 38.9018 | 1 | 1 |
| geminin | Homo sapiens (human) | Potency | 9.8845 | 2 | 2 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 1.9299 | 1 | 2 |
| glp-1 receptor, partial | Homo sapiens (human) | Potency | 0.7308 | 1 | 1 |
| GLS protein | Homo sapiens (human) | Potency | 20.8114 | 2 | 2 |
| Glutamate receptor 2 | Rattus norvegicus (Norway rat) | Potency | 26.9250 | 1 | 2 |
| Guanine nucleotide-binding protein G | Homo sapiens (human) | Potency | 1.0000 | 1 | 1 |
| Histamine H2 receptor | Cavia porcellus (domestic guinea pig) | Potency | 2.5119 | 1 | 3 |
| histone acetyltransferase KAT2A isoform 1 | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| histone deacetylase 9 isoform 3 | Homo sapiens (human) | Potency | 47.9539 | 2 | 3 |
| HLA class I histocompatibility antigen, B alpha chain | Homo sapiens (human) | Potency | 38.9018 | 1 | 1 |
| huntingtin isoform 2 | Homo sapiens (human) | Potency | 11.2202 | 1 | 1 |
| hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | Homo sapiens (human) | Potency | 0.2512 | 2 | 2 |
| Inositol hexakisphosphate kinase 1 | Homo sapiens (human) | Potency | 38.9018 | 1 | 2 |
| Interferon beta | Homo sapiens (human) | Potency | 19.6174 | 2 | 2 |
| lamin isoform A-delta10 | Homo sapiens (human) | Potency | 18.1863 | 1 | 2 |
| Luciferase | Photinus pyralis (common eastern firefly) | Potency | 27.0315 | 3 | 5 |
| mitogen-activated protein kinase 1 | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| NFKB1 protein, partial | Homo sapiens (human) | Potency | 3.5481 | 2 | 2 |
| nonstructural protein 1 | Influenza A virus (A/WSN/1933(H1N1)) | Potency | 0.3162 | 1 | 1 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 51.7881 | 2 | 3 |
| Nuclear receptor ROR-gamma | Homo sapiens (human) | Potency | 37.5780 | 1 | 1 |
| nuclear receptor subfamily 1, group I, member 3 | Homo sapiens (human) | Potency | 31.0829 | 3 | 9 |
| P53 | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
| peroxisome proliferator-activated receptor delta | Homo sapiens (human) | Potency | 11.8823 | 1 | 1 |
| phosphopantetheinyl transferase | Bacillus subtilis | Potency | 34.1050 | 1 | 3 |
| potassium voltage-gated channel subfamily H member 2 isoform d | Homo sapiens (human) | Potency | 30.3001 | 1 | 2 |
| pregnane X nuclear receptor | Homo sapiens (human) | Potency | 48.5797 | 2 | 5 |
| progesterone receptor | Homo sapiens (human) | Potency | 45.6353 | 1 | 2 |
| RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 15.7496 | 2 | 6 |
| ras-related protein Rab-9A | Homo sapiens (human) | Potency | 91.9997 | 1 | 1 |
| retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 22.5935 | 3 | 11 |
| retinoid X nuclear receptor alpha | Homo sapiens (human) | Potency | 29.3969 | 1 | 2 |
| SMAD family member 2 | Homo sapiens (human) | Potency | 27.5391 | 1 | 1 |
| SMAD family member 3 | Homo sapiens (human) | Potency | 27.5391 | 1 | 1 |
| Smad3 | Homo sapiens (human) | Potency | 3.9811 | 1 | 1 |
| Spike glycoprotein | Severe acute respiratory syndrome-related coronavirus | Potency | 35.4813 | 1 | 1 |
| TAR DNA-binding protein 43 | Homo sapiens (human) | Potency | 3.5481 | 1 | 1 |
| TDP1 protein | Homo sapiens (human) | Potency | 30.0534 | 2 | 2 |
| thioredoxin reductase | Rattus norvegicus (Norway rat) | Potency | 1.1220 | 1 | 1 |
| thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 28.2672 | 4 | 5 |
| USP1 protein, partial | Homo sapiens (human) | Potency | 63.0957 | 1 | 1 |
| Voltage-dependent calcium channel gamma-2 subunit | Mus musculus (house mouse) | Potency | 26.9250 | 1 | 2 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| Alcohol dehydrogenase E chain | Equus caballus (horse) | Ki | 0.1412 | 1 | 1 |
| Alcohol dehydrogenase S chain | Equus caballus (horse) | Ki | 0.1412 | 1 | 1 |
| Alpha-1A adrenergic receptor | Bos taurus (cattle) | Ki | 0.9332 | 1 | 1 |
| Alpha-1A adrenergic receptor | Homo sapiens (human) | Ki | 0.1622 | 1 | 1 |
| Alpha-1A adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 3.1311 | 2 | 2 |
| Alpha-1B adrenergic receptor | Homo sapiens (human) | Ki | 1.2589 | 1 | 1 |
| Alpha-1B adrenergic receptor | Mesocricetus auratus (golden hamster) | Ki | 1.2589 | 1 | 1 |
| Alpha-1B adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 6.1000 | 1 | 1 |
| Alpha-1D adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 3.1311 | 2 | 2 |
| Alpha-2A adrenergic receptor | Homo sapiens (human) | Ki | 0.3900 | 1 | 1 |
| Alpha-2A adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 0.3300 | 2 | 2 |
| Alpha-2B adrenergic receptor | Homo sapiens (human) | Ki | 0.3900 | 1 | 1 |
| Alpha-2B adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 0.3300 | 2 | 2 |
| Alpha-2C adrenergic receptor | Homo sapiens (human) | Ki | 0.3900 | 1 | 1 |
| Alpha-2C adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 0.3300 | 2 | 2 |
| Amine oxidase [flavin-containing] | Danio rerio (zebrafish) | Ki | 30.8000 | 1 | 1 |
| Amine oxidase [flavin-containing] B | Homo sapiens (human) | Ki | 3.1000 | 1 | 1 |
| Amine oxidase [flavin-containing] B | Rattus norvegicus (Norway rat) | Ki | 2.9000 | 1 | 1 |
| Angiotensin-converting enzyme | Homo sapiens (human) | IC50 | 7,079.4600 | 1 | 1 |
| Arachidonate 5-lipoxygenase-activating protein | Homo sapiens (human) | Ki | 0.1170 | 1 | 1 |
| ATP-binding cassette sub-family C member 3 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 1 |
| Beta-1 adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 13.0000 | 1 | 1 |
| Beta-carbonic anhydrase 1 | Mycobacterium tuberculosis H37Rv | Ki | 86.2525 | 3 | 4 |
| Bile salt export pump | Homo sapiens (human) | IC50 | 134.0000 | 2 | 2 |
| Canalicular multispecific organic anion transporter 1 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 1 |
| Carbonic anhydrase | Candida albicans SC5314 | Ki | 0.9728 | 4 | 6 |
| Carbonic anhydrase | Helicobacter pylori 26695 | Ki | 0.2245 | 2 | 2 |
| Carbonic anhydrase | Saccharomyces cerevisiae S288C | Ki | 0.1060 | 1 | 1 |
| Carbonic anhydrase | Stylophora pistillata | Ki | 0.6450 | 1 | 1 |
| Carbonic anhydrase | Anopheles gambiae (African malaria mosquito) | Ki | 0.2630 | 1 | 1 |
| Carbonic anhydrase | Astrosclera willeyana | Ki | 0.1650 | 1 | 1 |
| Carbonic anhydrase | Cryptococcus neoformans var. grubii | Ki | 1.0070 | 2 | 3 |
| Carbonic anhydrase | Mycobacterium tuberculosis H37Rv | Ki | 6.1550 | 1 | 2 |
| Carbonic anhydrase | Nakaseomyces glabratus CBS 138 | Ki | 0.1140 | 1 | 1 |
| Carbonic anhydrase | Stylophora pistillata | Ki | 0.2590 | 2 | 2 |
| Carbonic anhydrase | Sulfurihydrogenibium sp. YO3AOP1 | Ki | 0.1400 | 1 | 1 |
| Carbonic anhydrase 1 | Homo sapiens (human) | IC50 | 1.8600 | 1 | 1 |
| Carbonic anhydrase 1 | Homo sapiens (human) | Ki | 35.7691 | 53 | 79 |
| Carbonic anhydrase 12 | Homo sapiens (human) | IC50 | 1.8600 | 1 | 1 |
| Carbonic anhydrase 12 | Homo sapiens (human) | Ki | 120.9278 | 7 | 19 |
| Carbonic anhydrase 13 | Homo sapiens (human) | IC50 | 1.8600 | 1 | 1 |
| Carbonic anhydrase 13 | Homo sapiens (human) | Ki | 160.2182 | 2 | 14 |
| Carbonic anhydrase 14 | Homo sapiens (human) | IC50 | 1.8600 | 1 | 1 |
| Carbonic anhydrase 14 | Homo sapiens (human) | Ki | 126.0486 | 6 | 18 |
| Carbonic anhydrase 15 | Mus musculus (house mouse) | Ki | 0.4978 | 3 | 4 |
| Carbonic anhydrase 2 | Bos taurus (cattle) | IC50 | 1.8600 | 1 | 1 |
| Carbonic anhydrase 2 | Homo sapiens (human) | IC50 | 1.8600 | 1 | 1 |
| Carbonic anhydrase 2 | Homo sapiens (human) | Ki | 25.9533 | 65 | 92 |
| Carbonic anhydrase 2 | Mycobacterium tuberculosis H37Rv | Ki | 0.8760 | 1 | 1 |
| Carbonic anhydrase 3 | Homo sapiens (human) | IC50 | 1.8600 | 1 | 1 |
| Carbonic anhydrase 3 | Bos taurus (cattle) | Ki | 14.2620 | 2 | 5 |
| Carbonic anhydrase 3 | Homo sapiens (human) | Ki | 442.8417 | 3 | 15 |
| Carbonic anhydrase 4 | Homo sapiens (human) | IC50 | 1.8600 | 1 | 1 |
| Carbonic anhydrase 4 | Homo sapiens (human) | Ki | 98.2498 | 7 | 25 |
| Carbonic anhydrase 5A, mitochondrial | Homo sapiens (human) | IC50 | 1.8600 | 1 | 1 |
| Carbonic anhydrase 5A, mitochondrial | Homo sapiens (human) | Ki | 119.0908 | 7 | 19 |
| Carbonic anhydrase 5B, mitochondrial | Homo sapiens (human) | IC50 | 1.8600 | 1 | 1 |
| Carbonic anhydrase 5B, mitochondrial | Homo sapiens (human) | Ki | 436.8304 | 7 | 19 |
| Carbonic anhydrase 6 | Homo sapiens (human) | IC50 | 1.8600 | 1 | 1 |
| Carbonic anhydrase 6 | Homo sapiens (human) | Ki | 88.6655 | 8 | 26 |
| Carbonic anhydrase 7 | Homo sapiens (human) | IC50 | 1.8600 | 1 | 1 |
| Carbonic anhydrase 7 | Homo sapiens (human) | Ki | 97.5477 | 10 | 23 |
| Carbonic anhydrase 9 | Homo sapiens (human) | IC50 | 1.8600 | 1 | 1 |
| Carbonic anhydrase 9 | Homo sapiens (human) | Ki | 83.0922 | 12 | 27 |
| Carbonic anhydrase, alpha family | Hydrogenovibrio crunogenus XCL-2 | Ki | 0.4110 | 1 | 1 |
| Cytochrome P450 1A2 | Homo sapiens (human) | Ki | 9.0000 | 1 | 1 |
| D(2) dopamine receptor | Rattus norvegicus (Norway rat) | Ki | 6.0330 | 1 | 1 |
| Delta carbonic anhydrase | Conticribra weissflogii | Ki | 0.4040 | 1 | 1 |
| Delta-type opioid receptor | Mus musculus (house mouse) | Ki | 0.0455 | 2 | 2 |
| Delta-type opioid receptor | Rattus norvegicus (Norway rat) | Ki | 0.0278 | 2 | 2 |
| Deoxyhypusine hydroxylase | Homo sapiens (human) | IC50 | 5.0000 | 1 | 1 |
| Hepatocyte growth factor receptor | Homo sapiens (human) | IC50 | 20.0000 | 1 | 1 |
| Hormone-sensitive lipase | Rattus norvegicus (Norway rat) | IC50 | 3.2500 | 1 | 1 |
| Lysine-specific demethylase 2A | Homo sapiens (human) | IC50 | 6.8000 | 1 | 1 |
| Lysine-specific demethylase 2B | Homo sapiens (human) | IC50 | 8.1000 | 1 | 1 |
| Lysine-specific demethylase 4A | Homo sapiens (human) | IC50 | 3.2750 | 2 | 2 |
| Lysine-specific demethylase 5C | Homo sapiens (human) | IC50 | 5.6000 | 1 | 1 |
| Lysine-specific demethylase 6A | Homo sapiens (human) | IC50 | 4.2000 | 1 | 1 |
| Mu-type opioid receptor | Cavia porcellus (domestic guinea pig) | Ki | 0.0350 | 1 | 1 |
| Mu-type opioid receptor | Rattus norvegicus (Norway rat) | Ki | 0.0560 | 1 | 1 |
| Multidrug resistance-associated protein 4 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 1 |
| N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 | Homo sapiens (human) | Ki | 2,350.0000 | 1 | 2 |
| Nitric oxide synthase, brain | Homo sapiens (human) | Ki | 2,350.0000 | 1 | 2 |
| Nitric oxide synthase, brain | Rattus norvegicus (Norway rat) | Ki | 2,350.0000 | 1 | 2 |
| Polyunsaturated fatty acid 5-lipoxygenase | Homo sapiens (human) | Ki | 0.1170 | 1 | 1 |
| Prolyl endopeptidase | Rattus norvegicus (Norway rat) | Ki | 0.0200 | 1 | 1 |
| Replicase polyprotein 1ab | Betacoronavirus England 1 | IC50 | 10.0000 | 1 | 2 |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome coronavirus 2 | IC50 | 21.3420 | 3 | 5 |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome-related coronavirus | IC50 | 49.6000 | 2 | 3 |
| Sodium-dependent dopamine transporter | Rattus norvegicus (Norway rat) | Ki | 0.0352 | 1 | 1 |
| Transient receptor potential cation channel subfamily V member 1 | Rattus norvegicus (Norway rat) | Ki | 0.8480 | 1 | 1 |
| Translocator protein | Rattus norvegicus (Norway rat) | Ki | 38.4500 | 1 | 1 |