Luft Disease

Synonym
Luft Disease
Megaconial Myopathies
Luft's Disease
Mitochondrial Myopathy
Pleoconial Myopathies
Myopathies, Mitochondrial

Excerpt	Reference
"In conclusion, mitochondrial myopathies are associated with excessive neuroendocrine responses and mobilization of glucose during exercise."	( Galbo, H; Haller, RG; Vissing, J, 1996)
"The mitochondrial myopathies are a rare group of conditions affecting the respiratory chain and oxidative phosphorylation."	( Cheam, EW; Critchley, LA, 1998)
"The diagnosis of mitochondrial myopathy is reliant on the combination of numerous techniques including traditional histochemical, immunohistochemical, and biochemical testing combined with the fast-emerging molecular genetic techniques, namely next-generation sequencing (NGS)."	( Ahmed, ST; Craven, L; Russell, OM; Turnbull, DM; Vincent, AE, 2018)
"Mitochondrial myopathy is a rare side effect of entecavir and can be diagnosed by muscle biopsy."	( Chen, X; Lin, X; Song, A; Zheng, S, 2022)

Excerpt	Reference
"Characteristic mitochondrial myopathy was induced in the groups treated daily with 10 mg/kg of GeO2 or more."	( Kim, TS; Lee, IY; Yim, SY, 1999)
"Treatment options for mitochondrial myopathies remain limited despite rapid advances in the understanding of the molecular basis of these conditions."	( Chinnery, PF; Hassani, A; Horvath, R, 2010)
"For the mitochondrial myopathies, we discuss the importance of homoplasmic mitochondrial DNA mutations and review the rapid progress made in our understanding of the coenzyme Q(10) deficiencies, which are often treatable."	( DiMauro, S; Garone, C; Naini, A, 2010)
"Here, we treated mitochondrial myopathy mice with NR."	( Auranen, M; Auwerx, J; Carroll, CJ; Euro, L; Forsström, S; Khan, NA; Paetau, I; Pasila, L; Pirinen, E; Suomalainen, A; Velagapudi, V, 2014)
"The results of the Primary Mitochondrial Myopathy Symptom Assessment Total Fatigue and Total Fatigue During Activities scores showed that participants treated with elamipretide reported less fatigue and muscle complaints compared with placebo (P = 0."	( Cohen, BH; Goldstein, A; Haas, R; Karaa, A; Vockley, J, 2020)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	0 (0.00)	23.3326
1990's	179 (37.06)	12.5806
2000's	181 (37.47)	18.1394
2010's	101 (20.91)	28.8240
2020's	22 (4.55)	9.53

Drug	Relationship Strength	Studies	Trials
acetylcarnitine	low	1	0
adenine	low	3	0
adipic acid	low	1	0
ammonium hydroxide	low	1	0
carnitine	medium	38	2
chlorine	low	1	0
methylmalonic acid	low	1	0
malic acid	low	1	0
creatine	medium	8	4
cytosine	low	2	0
lactic acid	medium	56	10
glycine	medium	4	1
glycerol	low	1	0
hydrogen	low	1	0
thioctic acid	low	1	0
melatonin	low	2	0
niacinamide	low	4	0
niacin	low	1	0
nitrates	medium	1	1
nitrous oxide	low	1	0
orotic acid	low	1	0
pyruvic acid	medium	14	2
dithionite	low	1	0
succinic acid	low	3	0
taurine	low	1	0
thiamine	low	1	0
thymine	low	2	0
meglutol	low	1	0
3-nitropropionic acid	low	2	0
acetazolamide	medium	1	1
aspirin	medium	3	1
bisoprolol	low	2	0
bupivacaine	low	2	0
carbonyl cyanide m-chlorophenyl hydrazone	low	1	0
chloral hydrate	low	1	0
2,3-dimethoxy-5-methyl-6-decyl-1,4-benzoquinone	low	1	0
dequalinium	low	1	0
valproic acid	low	4	0
etidronate	low	2	0
carbonyl cyanide p-trifluoromethoxyphenylhydrazone	low	1	0
fentanyl	low	5	0
hydrochlorothiazide	low	1	0
idebenone	low	2	0
indomethacin	low	1	0
2-propanol	low	1	0
ketamine	low	5	0
metformin	low	1	0
metoprolol	low	1	0
midazolam	low	2	0
molsidomine	low	2	0
nevirapine	low	1	0
nitroglycerin	low	2	0
propofol	low	8	0
propranolol	low	2	0
risperidone	low	1	0
sevoflurane	low	1	0
risedronic acid	low	2	0
succinylcholine	low	1	0
suramin	medium	1	1
trimethoprim	low	1	0
thymidine	low	8	0
carbachol	low	1	0
prednisone	low	1	0
alanine	medium	6	1
serine	low	2	0
glutamine	low	2	0
cyanides	low	1	0
adenosine diphosphate	medium	15	3
uridine	low	5	0
galactose	low	1	0
leucine	low	4	0
asparagine	low	3	0
histidine	low	1	0
valine	low	1	0
threonine	low	1	0
isoleucine	low	1	0
arginine	low	5	0
dichloroacetic acid	medium	2	1
methylprednisolone	medium	3	1
rotenone	low	4	0
ambenonium chloride	low	1	0
diethylhexyl phthalate	low	1	0
potassium cyanide	low	3	0
methohexital	low	1	0
thiazoles	low	2	0
pyrazines	medium	1	1
aminoimidazole carboxamide	low	3	0
betamethasone	low	1	0
kainic acid	low	1	0
hematoxylin	low	1	0
tricaprylin	medium	1	1
malondialdehyde	low	1	0
eosine yellowish-(ys)	low	1	0
ethylmalonic acid	low	1	0
acetylcysteine	medium	3	1
3-methylglutaric acid	low	1	0
diphenyliodonium	low	1	0
deoxycytidine	low	2	0
germanium oxide	low	2	0
arsenic trioxide	low	1	0
d-alpha tocopherol	medium	5	1
pseudouridine	low	4	0
beta-hydroxymyristic acid	low	3	0
sulfadoxine	low	1	0
stavudine	low	1	0
9-amino-6-chloro-2-methoxyacridine	low	1	0
mono-(2-ethylhexyl)phthalate	low	1	0
gadolinium	low	1	0
zalcitabine	low	3	0
magnesium sulfate	low	1	0
deuterium	low	1	0
sodium selenite	low	2	0
barium chloride	low	1	0
osmium tetroxide	low	1	0
cetylpyridinium chloride anhydrous	low	1	0
4-methoxyamphetamine	low	1	0
glutamic acid	low	3	0
azides	low	1	0
gallium citrate	low	1	0
s-adenosylmethionine	low	10	0
zidovudine	medium	35	3
ribavirin	low	1	0
bezafibrate	low	7	0
ng-nitroarginine methyl ester	low	1	0
sufentanil	low	1	0
propiconazole	low	1	0
captopril	low	1	0
atracurium	low	2	0
fomesafen	low	1	0
lovastatin	low	2	0
simvastatin	low	2	0
pravastatin	low	1	0
fura-2	low	1	0
adefovir	low	1	0
remifentanil	low	1	0
lamivudine	low	5	0
adenosine	low	1	0
efavirenz	low	1	0
trimethoprim, sulfadoxine drug combination	low	1	0
aica ribonucleotide	low	3	0
guanidinopropionic acid	low	1	0
fluorodeoxyglucose f18	medium	2	1
triheptanoin	medium	1	1
rivastigmine	low	1	0
coenzyme a	low	1	0
arginine methyl ester	low	2	0
3-hydroxydodecanoic acid	low	1	0
5,6-dihydrouridine	low	1	0
benzyloxyamine	low	1	0
iodofiltic acid	low	1	0
caprylates	medium	1	1
peroxynitrous acid	low	1	0
telbivudine	low	3	0
ropivacaine	low	1	0
organophosphonates	low	1	0
4-aza-4-methylpregnane-3,20-dione	low	1	0
2'-fluorothymidine	low	4	0
carboplatin	low	1	0
glycogen	low	10	0
hexacyanoferrate iii	low	1	0
nicotinamide-beta-riboside	low	4	0
rocuronium	low	2	0
abacavir	low	2	0
phalloidine	low	1	0
tretinoin	low	1	0
resveratrol	medium	1	1
oleic acid	low	1	0
thapsigargin	low	2	0
riboflavin	low	9	0
sodium bicarbonate	low	1	0
phenyl-n-tert-butylnitrone	low	1	0
flavin-adenine dinucleotide	low	1	0
malonyl coenzyme a	low	2	0
pyrophosphate	low	1	0
3-methylglutaconic acid	low	5	0
nadp	low	5	0
valinomycin	low	1	0
2,4-dinitrophenylhydrazine	low	1	0
fumarylacetoacetate	low	1	0
linoleic acid	low	1	0
vitamin k semiquinone radical	medium	2	1
mivacurium	low	2	0
coenzyme q10	medium	27	3
morphine	low	1	0
acipimox	medium	1	1
dexmedetomidine	low	1	0
5,5',6,6'-tetrachloro-1,1',3,3'-tetraethylbenzimidazolocarbocyanine	low	1	0
arsenic	low	1	0
gallium	low	1	0
sulfur	low	2	0
cysteine	medium	3	1
phosphorus	medium	9	3
carbocyanines	low	1	0
germanium	low	2	0
selenium	low	1	0
antimycin a	low	2	0
myxothiazol	low	2	0
beta-escin	low	4	0
phosphocreatine	medium	19	3
chlorhexidine	low	1	0
etomoxir	low	1	0
d-arg-dmt-lys-phe-nh2	medium	5	3
technetium tc 99m exametazime	low	1	0
podophyllin	low	1	0
arabinofuranosyluracil	low	4	0
enerbol	low	1	0
3-hydroxypalmitic acid	low	3	0
nad	low	10	0
cytochrome c-t	low	3	0
anticodon	low	6	0
c-peptide	low	2	0
phosphatidylcholines	low	1	0
ubiquinone	medium	41	4
piperidines	low	1	0
interleukin-8	low	1	0
hydroxocobalamin	low	1	0
heme	low	1	0
ascorbic acid	medium	2	1
minocycline	low	1	0
antimycin	low	2	0
rta 408	medium	1	1
oligomycins	low	4	0
vitamin b 12	low	1	0
cyclosporine	low	1	0
digitonin	low	1	0
5-taurinomethyluridine	low	1	0
entecavir	low	1	0
deoxyguanosine	low	2	0
guanosine diphosphate	low	1	0
guanosine triphosphate	low	1	0
guanine	low	4	0
guanosine	low	1	0
folic acid	low	2	0
didanosine	low	1	0
pemetrexed	low	1	0
8-hydroxy-2'-deoxyguanosine	low	1	0
phosphorus radioisotopes	low	2	0
pyrimidinones	low	1	0

Protein Targets (1,432)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
hypoxia-inducible factor 1 alpha subunit	16	0	0	16
RAR-related orphan receptor gamma	39	0	0	39
GLI family zinc finger 3	38	0	0	38
AR protein	49	0	0	49
aldehyde dehydrogenase 1 family, member A1	30	0	0	30
retinoic acid nuclear receptor alpha variant 1	46	0	0	46
retinoid X nuclear receptor alpha	36	0	0	36
estrogen nuclear receptor alpha	62	0	0	62
peroxisome proliferator-activated receptor delta	25	0	0	25
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	24	0	0	24
activating transcription factor 6	20	0	0	20
v-jun sarcoma virus 17 oncogene homolog (avian)	23	0	0	23
Histone H2A.x	13	0	0	13
thyroid hormone receptor beta isoform a	22	0	0	22
heat shock protein beta-1	20	0	0	20
nuclear factor erythroid 2-related factor 2 isoform 1	34	0	0	34
lamin isoform A-delta10	40	0	0	40
Voltage-dependent calcium channel gamma-2 subunit	20	0	0	20
Glutamate receptor 2	21	4	2	27
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	20	0	0	20
Chain A, Putative fructose-1,6-bisphosphate aldolase	10	0	0	10
Chain A, Ferritin light chain	16	0	0	16
TDP1 protein	38	0	0	38
Microtubule-associated protein tau	20	0	0	20
regulator of G-protein signaling 4	15	0	0	15
euchromatic histone-lysine N-methyltransferase 2	45	0	0	45
vitamin D3 receptor isoform VDRA	15	0	0	15
Dihydroorotate dehydrogenase (quinone), mitochondrial	0	0	0	1
Dihydroorotate dehydrogenase (quinone), mitochondrial	0	0	0	1
Free fatty acid receptor 1	0	0	2	2
Free fatty acid receptor 4	0	0	2	2
G-protein coupled receptor 84	0	2	2	4
glp-1 receptor, partial	8	0	0	8
geminin	39	0	0	39
acetylcholinesterase	20	0	0	20
thioredoxin reductase	22	0	0	22
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	10	0	0	10
progesterone receptor	24	0	0	24
glucocorticoid receptor [Homo sapiens]	40	0	0	40
estrogen-related nuclear receptor alpha	47	0	0	47
vitamin D (1,25- dihydroxyvitamin D3) receptor	27	0	0	27
aryl hydrocarbon receptor	13	0	0	13
thyrotropin-releasing hormone receptor	8	0	0	8
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	16	0	0	16
Bloom syndrome protein isoform 1	19	0	0	19
hemoglobin subunit beta	1	0	0	1
chromobox protein homolog 1	30	0	0	30
DNA polymerase iota isoform a (long)	13	0	0	13
muscarinic acetylcholine receptor M1	12	0	0	12
Cellular tumor antigen p53	39	0	0	39
Delta-aminolevulinic acid dehydratase	0	2	0	2
Isocitrate lyase 1	0	1	0	1
Isocitrate lyase	0	1	0	1
TAR DNA-binding protein 43	9	0	0	9
Isocitrate lyase	0	1	0	1
5-hydroxytryptamine receptor 2C	0	4	1	5
5-hydroxytryptamine receptor 2A	0	5	1	6
5-hydroxytryptamine receptor 1A	0	7	3	14
5-hydroxytryptamine receptor 1B	0	5	1	6
5-hydroxytryptamine receptor 1D	0	1	1	2
5-hydroxytryptamine receptor 1F	0	1	1	2
5-hydroxytryptamine receptor 2B	0	5	1	6
5-hydroxytryptamine receptor 6	0	0	1	1
Sodium-dependent serotonin transporter	0	4	1	5
Sodium-dependent serotonin transporter	0	4	0	4
5-hydroxytryptamine receptor 7	0	1	1	2
5-hydroxytryptamine receptor 5A	0	0	1	1
5-hydroxytryptamine receptor 5B	0	0	1	1
5-hydroxytryptamine receptor 3A	0	0	1	1
5-hydroxytryptamine receptor 4	0	0	1	1
5-hydroxytryptamine receptor 3B	0	0	1	1
Cytidine deaminase	0	2	0	3
Chain A, Avidin	0	0	2	2
Chain A, Avidin	0	0	2	2
Chain B, Avidin	0	0	2	2
Coagulation factor XII	0	1	0	1
Acetylcholinesterase	0	5	0	5
Liver carboxylesterase 1	0	2	0	2
Trypanothione reductase	0	2	0	2
Luciferase	17	0	0	17
cytochrome P450 family 3 subfamily A polypeptide 4	31	0	0	31
cytochrome P450 2D6	16	0	0	16
peripheral myelin protein 22	21	0	0	21
Albumin	0	2	9	11
ATP-dependent translocase ABCB1	0	14	0	19
Replicase polyprotein 1ab	0	1	1	2
Replicase polyprotein 1ab	0	1	1	2
Reverse transcriptase/RNaseH	0	10	9	33
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	2	0	2
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, Carbonic Anhydrase Ii	0	0	1	1
Chain A, Carbonic Anhydrase Ii	0	0	1	1
Chain A, Beta-lactamase	12	0	0	12
Chain A, Endochitinase	0	1	0	1
Chain A, Endochitinase	0	1	0	1
Chain A, Endochitinase	0	1	0	1
Chain A, Class Iii Chitinase Chia1	0	1	0	1
Chain A, Carbonic anhydrase 13	0	1	0	1
Chain A, Carbonic anhydrase II	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase	0	1	0	1
Chain B, Carbonic anhydrase	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase	0	3	0	3
GALC protein	5	0	0	5
nuclear receptor subfamily 1, group I, member 3	24	0	0	24
Carbonic anhydrase	0	2	0	2
Carbonic anhydrase	0	1	0	1
arylsulfatase A	13	0	0	13
Carbonic anhydrase	0	1	0	1
survival motor neuron protein isoform d	17	0	0	17
muscleblind-like protein 1 isoform 1	3	0	0	3
Gamma-aminobutyric acid receptor subunit pi	19	6	3	28
ATP-binding cassette sub-family C member 3	0	31	0	31
Multidrug resistance-associated protein 4	0	31	0	32
Carbonic anhydrase	0	1	0	1
Solute carrier family 22 member 6	0	6	0	8
Carbonic anhydrase 12	0	4	1	8
Prolyl endopeptidase	0	1	0	1
Carbonic anhydrase-related protein 11	0	1	0	2
Bile salt export pump	0	44	0	44
Glycogen phosphorylase, muscle form	0	1	0	1
Renin	0	4	0	4
Carbonic anhydrase 1	0	14	1	25
Carbonic anhydrase 2	0	15	1	25
Carbonic anhydrase 2	0	2	0	2
Cytochrome P450 1A2	0	4	1	5
Carbonic anhydrase 3	0	4	1	8
Cathepsin B	0	1	0	1
Cytochrome P450 3A4	0	10	2	13
Steryl-sulfatase	0	1	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	4	0	4
Cytochrome P450 2C8	0	2	0	2
Cytochrome P450 2D6	0	6	1	7
Cytochrome P450 2A6	0	2	0	2
Cytochrome P450 2C9	0	10	2	12
Androgen receptor	0	5	0	5
Gamma-aminobutyric acid receptor subunit beta-1	19	6	3	28
Translocator protein	0	2	1	3
Gamma-aminobutyric acid receptor subunit delta	19	6	3	28
Gamma-aminobutyric acid receptor subunit gamma-2	19	6	3	28
Gamma-aminobutyric acid receptor subunit alpha-5	19	6	3	28
Gamma-aminobutyric acid receptor subunit alpha-3	19	6	3	28
Cannabinoid receptor 1	0	1	0	1
Arachidonate 5-lipoxygenase-activating protein	0	1	0	1
Cytochrome P450 2B6	0	1	0	2
Carbonic anhydrase 4	0	9	1	12
Carbonic anhydrase 6	0	5	1	8
Gamma-aminobutyric acid receptor subunit gamma-1	19	6	3	28
Gamma-aminobutyric acid receptor subunit alpha-2	19	6	3	28
Carbonic anhydrase 5A, mitochondrial	0	1	0	1
Adenosine receptor A1	0	5	1	7
Serum paraoxonase/arylesterase 1	0	2	0	2
Dipeptidyl peptidase 4	0	3	0	4
Gamma-aminobutyric acid receptor subunit alpha-4	19	6	3	28
Gamma-aminobutyric acid receptor subunit gamma-3	19	6	3	28
Endochitinase	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	19	6	3	28
Adenosine receptor A2a	0	4	1	6
Delta-type opioid receptor	0	6	0	8
Cytochrome P450 2C19	0	5	1	6
Delta-type opioid receptor	0	7	1	9
Mu-type opioid receptor	0	11	2	16
Carbonic anhydrase 5A, mitochondrial	0	5	1	9
Carbonic anhydrase	0	7	0	8
Kappa-type opioid receptor	0	7	0	7
Carbonic anhydrase 7	0	4	1	7
Carbonic anhydrase	0	1	0	1
D(1A) dopamine receptor	4	1	0	5
Corticosteroid 11-beta-dehydrogenase isozyme 1	0	1	0	1
Carbonic anhydrase	0	1	0	2
D(2) dopamine receptor	0	3	0	3
Gamma-aminobutyric acid receptor subunit alpha-1	19	7	3	29
Gamma-aminobutyric acid receptor subunit beta-3	19	6	3	28
Gamma-aminobutyric acid receptor subunit beta-2	19	6	3	28
Cholinesterase	0	5	1	6
Carbonic anhydrase	0	1	0	1
Mu-type opioid receptor	0	7	1	8
Fatty-acid amide hydrolase 1	0	4	0	4
Beta-carbonic anhydrase 1	0	1	0	1
Carbonic anhydrase 2	0	1	0	1
Glutamate receptor ionotropic, NMDA 2B	0	9	3	13
Squalene synthase	0	2	0	2
Neuronal acetylcholine receptor subunit alpha-7	0	2	0	2
Carbonic anhydrase 9	0	5	1	9
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase, alpha family	0	2	0	2
Carbonic anhydrase	0	1	0	2
Carbonic anhydrase 3	0	1	0	1
Carbonic anhydrase	0	1	0	3
Carbonic anhydrase	0	1	0	3
Carbonic anhydrase	0	2	0	2
Sigma intracellular receptor 2	0	2	0	2
Delta carbonic anhydrase	0	2	0	2
Sigma non-opioid intracellular receptor 1	0	7	1	8
Renin	0	1	0	1
Carbonic anhydrase	0	1	0	2
Endochitinase A1	0	1	0	1
Multidrug resistance-associated protein 1	0	1	0	1
Carbonic anhydrase 13	0	3	1	6
GABA theta subunit	19	6	3	28
Canalicular multispecific organic anion transporter 1	0	31	0	31
Carbonic anhydrase 4	0	2	0	4
Carbonic anhydrase 15	0	6	0	8
Acidic mammalian chitinase	0	1	0	1
Carbonic anhydrase 13	0	3	0	5
Carbonic anhydrase 7	0	1	0	1
Gamma-aminobutyric acid receptor subunit epsilon	19	6	3	28
Carbonic anhydrase	0	2	0	2
Carbonic anhydrase 14	0	4	1	8
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 2, isoform A	0	1	0	1
Carbonic anhydrase 5B, mitochondrial	0	5	1	9
N-alpha-acetyltransferase 50	0	0	2	2
Chain A, JmjC domain-containing histone demethylation protein 3A	12	0	0	12
Chain A, 2-oxoglutarate Oxygenase	13	0	0	13
Chain A, ATP-DEPENDENT DNA HELICASE Q1	9	0	0	9
dopamine D1 receptor	2	0	0	2
15-lipoxygenase, partial	11	0	0	11
pregnane X receptor	10	0	0	10
phosphopantetheinyl transferase	24	0	0	24
USP1 protein, partial	20	0	0	20
NFKB1 protein, partial	4	0	0	4
Thrombopoietin	4	0	0	4
farnesoid X nuclear receptor	28	0	0	28
D(1A) dopamine receptor	7	0	0	7
thyroid hormone receptor beta isoform 2	29	0	0	29
flap endonuclease 1	11	0	0	11
Histone deacetylase 3	0	3	0	3
Histone deacetylase 4	0	3	0	3
Guanine nucleotide-binding protein G	5	0	0	5
Histone deacetylase 1	0	4	0	4
Histone deacetylase 7	0	3	0	3
Histone deacetylase 2	0	4	0	4
Polyamine deacetylase HDAC10	0	3	0	3
Histone deacetylase 11	0	3	0	3
Ataxin-2	20	0	0	20
Histone deacetylase 8	0	3	0	3
Histone deacetylase 6	0	4	0	4
Histone deacetylase 9	0	3	0	3
Histone deacetylase 5	0	3	0	3
ATP-dependent phosphofructokinase	21	0	0	21
Fumarate hydratase	5	0	0	5
EWS/FLI fusion protein	21	0	0	21
polyprotein	5	0	0	5
histone acetyltransferase KAT2A isoform 1	16	0	0	16
Hydroxycarboxylic acid receptor 2	0	2	2	4
potassium voltage-gated channel subfamily H member 2 isoform d	7	0	0	7
Phosphoribosyl pyrophosphate synthase-associated protein 2	0	1	0	2
Adenylate kinase isoenzyme 1	0	0	0	1
Adenylate kinase 2, mitochondrial	0	0	0	1
Adenosine deaminase	0	1	0	3
Capsid protein	0	1	4	5
Solute carrier family 22 member 6	0	3	0	5
Solute carrier family 22 member 8	0	2	0	4
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	33	0	0	33
Chain A, MTA/SAH nucleosidase	0	1	0	1
Chain A, Ribosome-inactivating protein alpha-trichosanthin	0	0	1	1
Chain A, Ricin A chain	0	0	1	1
Chain A, Ribosome-inactivating protein 3	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
pregnane X nuclear receptor	29	0	0	29
nuclear factor erythroid 2-related factor 2 isoform 2	15	0	0	15
importin subunit beta-1 isoform 1	7	0	0	7
snurportin-1	7	0	0	7
tumor susceptibility gene 101 protein	2	0	0	2
GTP-binding nuclear protein Ran isoform 1	3	0	0	3
Cyclin-dependent kinase 1	0	1	0	1
Heat shock protein HSP 90-beta	0	2	1	4
Xanthine dehydrogenase/oxidase	0	2	0	2
Protein mono-ADP-ribosyltransferase PARP15	0	3	0	3
Leucine-rich repeat serine/threonine-protein kinase 2	0	2	0	2
ATPase family AAA domain-containing protein 5	14	0	0	14
Chain A, Membrane lipoprotein tmpC	0	0	2	2
Chain A, Membrane lipoprotein tmpC	0	0	2	2
Chain A, Membrane lipoprotein tmpC	0	0	2	2
Chain A, Structure of PAE2307 in complex with adenosine	0	0	1	1
Chain B, Structure of PAE2307 in complex with adenosine	0	0	1	1
Chain A, ADENOSINE RECEPTOR A2A	0	1	0	1
Chain A, ADENOSINE RECEPTOR A2A	0	1	0	1
Chain A, tRNA (guanine-N(1)-)-methyltransferase	0	0	1	1
Chain A, Uncharacterized protein MJ0883	0	0	1	1
signal transducer and activator of transcription 6, interleukin-4 induced	1	0	0	1
NPYLR7B	0	0	3	3
IDH1	15	0	0	15
glycogen synthase kinase-3 beta isoform 1	0	0	2	2
mitogen-activated protein kinase 1	10	0	0	10
nuclear receptor ROR-gamma isoform 1	18	0	0	18
high affinity choline transporter 1 isoform a	0	1	0	1
Sodium/nucleoside cotransporter 1	0	4	0	4
Calcium dependent protein kinase	0	1	0	1
Mitogen-activated protein kinase kinase kinase 7	0	0	2	2
Sodium/nucleoside cotransporter 2	0	4	0	4
Rap guanine nucleotide exchange factor 3	8	0	0	8
Purine nucleoside phosphorylase	0	3	0	4
Epidermal growth factor receptor	0	3	0	3
Phosphoglycerate kinase 1	0	1	0	1
Adenosine deaminase	0	0	0	1
Avidin	0	0	1	1
Adenosine deaminase	0	0	0	1
Glyceraldehyde-3-phosphate dehydrogenase	0	2	0	2
Receptor tyrosine-protein kinase erbB-2	0	1	0	1
Insulin receptor	0	0	0	1
Phosphoglycerate kinase 2	0	1	0	1
Heat shock protein HSP 90-alpha	0	2	2	5
Platelet-derived growth factor receptor beta	0	0	0	1
Adenosine receptor A3	0	6	3	10
Heat shock 70 kDa protein 1A	0	2	1	3
Heat shock cognate 71 kDa protein	0	0	2	2
Fibroblast growth factor receptor 1	0	0	0	1
Inosine-5'-monophosphate dehydrogenase 2	0	1	0	1
Endoplasmin	0	1	1	3
Inosine-5'-monophosphate dehydrogenase 1	0	1	0	1
Fibroblast growth factor receptor 2	0	0	0	1
Fibroblast growth factor receptor 4	0	0	0	1
Fibroblast growth factor receptor 3	0	0	0	1
Streptavidin	0	0	1	1
Adenosylhomocysteinase	0	1	0	5
Adenosine receptor A3	0	1	0	1
Adenosine receptor A2a	0	3	3	7
Adenosine receptor A2b	0	0	1	2
Adenosine receptor A2b	0	1	1	2
Adenylate kinase 2, mitochondrial	0	1	0	1
Adenosine receptor A1	0	5	2	8
Adenylate kinase isoenzyme 1	0	1	0	1
Phosphatidylinositol 4-kinase alpha	0	4	0	5
Adenosine receptor A1	0	0	1	1
Adenosine kinase	0	0	0	1
Equilibrative nucleoside transporter 2	0	4	0	4
Phosphatidylinositol 4-kinase type 2-beta	0	4	0	5
Histone-lysine N-methyltransferase, H3 lysine-79 specific	0	1	0	1
Equilibrative nucleoside transporter 1	0	4	0	4
Phosphatidylinositol 4-kinase type 2-alpha	0	4	0	5
Solute carrier family 28 member 3	0	4	0	4
Adenosine kinase	0	1	0	2
Phosphatidylinositol 4-kinase beta	0	4	0	5
5-methylthioadenosine/S-adenosylhomocysteine deaminase	0	0	0	1
Adenosine transporter 1	0	0	0	1
Chain A, Heat Shock Protein 90	0	0	1	1
Chain A, GLUTAMINE PHOSPHORIBOSYLPYROPHOSPHATE AMIDOTRANSFERASE	0	0	1	1
Chain B, GLUTAMINE PHOSPHORIBOSYLPYROPHOSPHATE AMIDOTRANSFERASE	0	0	1	1
Chain A, EOSINOPHIL-DERIVED NEUROTOXIN	0	1	0	1
Chain A, EOSINOPHIL-DERIVED NEUROTOXIN	0	1	0	1
Chain A, EOSINOPHIL-DERIVED NEUROTOXIN	0	1	0	1
Chain A, Myosin Ie Heavy Chain	0	0	1	1
Chain A, Preprotein translocase secA	0	0	1	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, Phosphoribosylformylglycinamidine synthase	0	1	0	1
Chain A, nucleoside diphosphate kinase A	0	0	1	1
Chain B, nucleoside diphosphate kinase A	0	0	1	1
Chain D, DNA polymerase III subunit gamma	0	0	1	1
Chain D, DNA polymerase III subunit gamma	0	0	1	1
Chain A [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 3	0	0	1	1
Chain A [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 3	0	0	1	1
Chain A, Kinesin-like protein KIF11	0	1	0	1
HPr kinase/phosphorylase	0	0	1	1
ATP-dependent molecular chaperone HSP82	0	0	0	1
2-dehydropantoate 2-reductase	0	1	3	4
Endoplasmic reticulum chaperone BiP	0	0	1	1
Pyruvate kinase PKM	0	0	0	1
Pyruvate kinase PKLR	0	0	0	1
Heat shock cognate 71 kDa protein	0	0	1	1
5'-nucleotidase	0	1	0	1
Mu-type opioid receptor	0	5	6	12
Delta-type opioid receptor	0	5	4	10
Kappa-type opioid receptor	0	5	4	10
Endoplasmin	0	1	1	2
P2Y purinoceptor 2	0	1	2	3
P2X purinoceptor 1	0	0	2	2
P2Y purinoceptor 1	0	0	1	1
P2Y purinoceptor 1	0	0	2	2
P2X purinoceptor 1	0	0	1	1
P2X purinoceptor 4	0	0	2	2
P2X purinoceptor 5	0	0	2	2
P2X purinoceptor 6	0	0	2	2
P2X purinoceptor 3	0	0	2	2
Inositol monophosphatase 1	10	0	0	10
Heat shock protein 75 kDa, mitochondrial	0	1	0	1
P2Y purinoceptor 6	0	1	2	3
P2Y purinoceptor 11	0	1	2	3
P2Y purinoceptor 12	0	1	2	3
Sensor protein kinase WalK	0	1	0	1
P2X purinoceptor 2	0	0	1	1
lethal factor (plasmid)	14	0	0	14
Solute carrier family 22 member 20	0	3	0	3
Solute carrier family 22 member 6	0	3	0	3
Fructose-1,6-bisphosphatase 1	0	1	0	2
Bifunctional purine biosynthesis protein ATIC	0	3	0	4
Histidine triad nucleotide-binding protein 1	0	0	1	1
Alanine racemase, biosynthetic	0	0	0	1
5-hydroxytryptamine receptor 1D	0	0	0	2
Glutamate receptor ionotropic, NMDA 1	0	9	3	13
Proton-coupled amino acid transporter 1	0	8	0	9
Adenosine deaminase	0	0	0	1
aryl hydrocarbon receptor nuclear translocator	0	0	0	1
apical membrane antigen 1, AMA1	3	0	0	3
transforming acidic coiled-coil-containing protein 3	0	0	0	1
Glutaminyl-peptide cyclotransferase	0	2	0	2
Guanine deaminase	0	1	0	2
cytochrome P450 3A4 isoform 1	19	0	0	19
caspase-1 isoform alpha precursor	2	0	0	2
NAD-dependent protein deacylase sirtuin-5, mitochondrial	0	4	0	4
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	2	2
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	2	2
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	2	2
GLS protein	12	0	0	12
thyroid stimulating hormone receptor	17	0	0	17
alpha-galactosidase	3	0	0	3
cytochrome P450 2C19 precursor	8	0	0	8
Nitric oxide synthase, endothelial	0	1	0	3
Nitric oxide synthase, brain	0	1	0	2
Nitric oxide synthase, brain	0	0	0	1
Nitric oxide synthase, inducible	0	3	0	4
Nitric oxide synthase, inducible	0	1	1	4
Cationic amino acid transporter 3	0	1	0	1
peroxisome proliferator activated receptor gamma	28	0	0	28
nuclear receptor subfamily 1, group I, member 2	7	0	0	7
Chain A, Hyaluronidase, phage associated	0	1	0	1
thioredoxin glutathione reductase	8	0	0	8
lethal(3)malignant brain tumor-like protein 1 isoform I	3	0	0	3
Polyphenol oxidase 2	0	4	0	4
Pancreatic alpha-amylase	0	2	0	2
Albumin	0	1	0	1
Urease	0	1	0	1
Prolyl 4-hydroxylase subunit alpha-1	0	0	0	1
Tyrosinase	0	2	0	2
Alpha-2B adrenergic receptor	0	2	2	5
Spike glycoprotein	17	0	1	18
Hyaluronate lyase	0	1	0	1
Prolyl hydroxylase EGLN2	0	0	0	1
Egl nine homolog 1	0	1	1	3
Prolyl hydroxylase EGLN3	0	0	0	1
Hypoxia-inducible factor 1-alpha inhibitor	0	0	0	1
Solute carrier family 23 member 1	0	1	0	1
Neutral amino acid transporter A	0	3	0	3
Neutral amino acid transporter B(0)	0	3	0	3
Carbonic anhydrase-like protein, putative	0	0	0	4
Amino acid transporter	0	3	0	3
Chain A, Phospholipase A2 isoform 3	0	0	1	1
Chain A, HADH2 protein	15	0	0	15
Chain B, HADH2 protein	15	0	0	15
GTP-binding protein (rab7)	0	0	1	1
ras protein, partial	0	0	1	1
interleukin 8	9	0	0	9
hypothetical protein, conserved	2	0	0	2
glucocerebrosidase	7	0	0	7
Rac1 protein	0	0	1	1
cell division cycle 42 (GTP binding protein, 25kDa), partial	0	0	1	1
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	9	0	0	9
DNA polymerase kappa isoform 1	19	0	0	19
Prostaglandin-H2 D-isomerase	0	2	0	2
Prostaglandin G/H synthase 1	0	4	0	5
Prostaglandin G/H synthase 2	0	2	0	3
Fatty acid-binding protein, liver	0	3	0	3
Integrin beta-3	6	1	1	8
Myeloperoxidase	0	3	0	3
Prostaglandin G/H synthase 1	0	4	1	6
Seed linoleate 13S-lipoxygenase-1	0	3	0	3
Integrin alpha-IIb	6	1	1	8
Glutathione hydrolase 1 proenzyme	0	1	0	1
Prostaglandin G/H synthase 1	0	7	0	7
Substance-P receptor	0	2	0	2
Prostaglandin G/H synthase 2	0	9	1	10
Urotensin-2 receptor	0	1	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	1	0	1
Nuclear receptor ROR-gamma	13	1	1	15
Ras-related protein Rab-2A	0	0	1	1
Prostaglandin G/H synthase 2	0	6	0	6
Rho-associated protein kinase 2	0	2	0	2
Nicotinate phosphoribosyltransferase	0	2	0	2
Sigma non-opioid intracellular receptor 1	0	5	1	6
Sigma non-opioid intracellular receptor 1	0	1	1	2
Amine oxidase [flavin-containing] A	0	1	1	2
Small conductance calcium-activated potassium channel protein 3	0	1	1	2
Indoleamine 2,3-dioxygenase 1	0	1	0	1
galanin receptor type 3	0	1	0	1
Glucocorticoid receptor	0	6	1	7
Glycine receptor subunit alpha-1	0	6	0	6
Glycine receptor subunit beta	0	6	0	6
Glycine receptor subunit alpha-2	0	6	0	6
Glycine receptor subunit alpha-3	0	6	0	6
ORF73	0	0	1	1
G	16	0	0	16
Glutamate receptor ionotropic, NMDA 2D	0	2	1	3
Glutamate receptor ionotropic, NMDA 3B	0	2	1	3
Bile salt export pump	0	3	0	3
5-hydroxytryptamine receptor 4	0	6	1	7
Interferon beta	18	0	0	18
HLA class I histocompatibility antigen, B alpha chain	16	0	0	16
Muscarinic acetylcholine receptor M1	0	3	2	7
Muscarinic acetylcholine receptor M3	0	3	2	6
Muscarinic acetylcholine receptor M4	0	3	1	5
Muscarinic acetylcholine receptor M5	0	3	1	5
Muscarinic acetylcholine receptor M2	0	3	1	5
Fatty acid-binding protein, intestinal	0	1	0	1
Peroxisome proliferator-activated receptor alpha	0	0	1	1
Peroxisome proliferator-activated receptor delta	0	0	1	1
Peroxisome proliferator-activated receptor gamma	0	0	2	2
Peroxisome proliferator-activated receptor gamma	0	0	1	1
Peroxisome proliferator-activated receptor delta	0	0	1	2
Glutamate receptor ionotropic, NMDA 1	0	3	1	4
Peroxisome proliferator-activated receptor alpha	3	0	2	5
Glutamate receptor ionotropic, NMDA 2A	0	3	1	4
Glutamate receptor ionotropic, NMDA 2B	0	3	1	4
Glutamate receptor ionotropic, NMDA 2C	0	2	1	3
Glutamate receptor ionotropic, NMDA 3A	0	2	1	3
Inositol hexakisphosphate kinase 1	16	0	0	16
cytochrome P450 2C9, partial	16	0	0	16
ATAD5 protein, partial	11	0	0	11
Beta-2 adrenergic receptor	0	5	3	8
Beta-1 adrenergic receptor	0	4	3	7
Beta-3 adrenergic receptor	0	2	3	5
Beta-1 adrenergic receptor	0	3	0	3
Potassium channel subfamily K member 3	0	2	0	2
Potassium channel subfamily K member 3	0	1	0	1
Potassium channel subfamily K member 2	0	0	1	1
Potassium channel subfamily K member 9	0	1	0	1
Chain A, Beta-lactoglobulin	0	0	1	1
Chain A, Beta-lactoglobulin	0	0	1	1
UDP-3-O-acyl-N-acetylglucosamine deacetylase	0	0	1	1
Chain A, angiotensin converting enzyme	0	1	0	1
Chain A, angiotensin converting enzyme	0	1	0	1
Metallo-beta-lactamase type 2	0	1	1	2
peripheral myelin protein 22 isoform 1	9	0	0	9
M-phase phosphoprotein 8	7	0	0	7
transient receptor potential cation channel subfamily V member 1	1	0	0	1
Prothrombin	0	1	1	2
Neprilysin	0	1	0	1
Neprilysin	0	1	0	1
Leukotriene A-4 hydrolase	0	3	1	4
EEF1AKMT4-ECE2 readthrough transcript protein	0	1	0	1
Angiotensin-converting enzyme	0	2	1	3
Angiotensin-converting enzyme	0	4	0	5
Leukotriene A-4 hydrolase	0	1	0	1
Thymidine phosphorylase	0	0	1	2
Endothelin-converting enzyme 1	0	1	0	1
Succinyl-diaminopimelate desuccinylase	0	2	0	2
Angiotensin-converting enzyme	0	2	0	2
Solute carrier family 15 member 1	0	1	0	1
Beta-lactamase TEM	0	1	0	1
Beta-lactamase	0	2	0	3
Beta-lactamase	0	2	0	2
Angiotensin-converting enzyme 2	0	1	1	2
Beta-lactamase class B VIM-2	0	1	1	2
thyroid stimulating hormone receptor	12	0	0	12
Neuronal acetylcholine receptor subunit alpha-3	0	1	0	1
Muscarinic acetylcholine receptor M2	0	4	3	8
Muscarinic acetylcholine receptor M4	0	3	2	6
Muscarinic acetylcholine receptor M5	0	3	2	6
Neuronal acetylcholine receptor subunit alpha-4	1	3	0	4
Muscarinic acetylcholine receptor M1	0	4	3	8
Neuronal acetylcholine receptor subunit alpha-2	0	1	0	1
Neuronal acetylcholine receptor subunit beta-2	1	3	0	4
Neuronal acetylcholine receptor subunit beta-3	0	1	0	1
Neuronal acetylcholine receptor subunit beta-4	0	1	0	1
Muscarinic acetylcholine receptor M1	0	1	1	2
Muscarinic acetylcholine receptor M3	0	5	3	9
Neuronal acetylcholine receptor subunit alpha-5	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-6	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-9	0	1	0	1
Muscarinic acetylcholine receptor	0	2	0	2
Muscarinic acetylcholine receptor M3	0	0	1	3
Muscarinic acetylcholine receptor M2	0	0	0	3
Neuronal acetylcholine receptor subunit alpha-10	0	1	0	1
Lactoperoxidase	0	1	0	1
Chain A, PAPAIN	1	0	0	1
Chain A, Cruzipain	9	0	0	9
SMAD family member 2	16	0	0	16
SMAD family member 3	16	0	0	16
estrogen receptor 2 (ER beta)	23	0	0	23
histone deacetylase 9 isoform 3	2	0	0	2
Polyunsaturated fatty acid lipoxygenase ALOX15B	7	0	0	7
Histamine H2 receptor	11	0	0	11
CDGSH iron-sulfur domain-containing protein 1	0	2	0	2
cellular tumor antigen p53 isoform a	7	0	0	7
Hypoxia-inducible factor 1-alpha	0	1	0	1
Endothelial PAS domain-containing protein 1	0	1	0	1
histone-lysine N-methyltransferase 2A isoform 2 precursor	4	0	0	4
Solute carrier family 22 member 5	0	0	0	1
Solute carrier family 22 member 5	0	0	0	1
Solute carrier family 22 member 16	0	0	0	1
Solute carrier family 22 member 21	0	0	0	1
Solute carrier family 22 member 5	0	0	0	1
caspase 7, apoptosis-related cysteine protease	9	0	0	9
67.9K protein	9	0	0	9
caspase-3	9	0	0	9
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	6	0	0	6
Caspase-2	0	0	1	1
Chain A, BCL-2-RELATED PROTEIN A1	0	0	2	2
acid sphingomyelinase	3	0	0	3
PAX8	0	0	0	1
PINK1	3	0	0	3
Parkin	7	0	0	7
heat shock protein 90	0	0	1	1
calcineurin A1, putative	0	0	1	1
cytochrome P450 2D6 isoform 1	6	0	0	6
hepatocyte nuclear factor 4-alpha isoform 2	0	1	0	1
cytochrome P450 2C9 precursor	5	0	0	5
perilipin-5	0	1	0	1
perilipin-1	0	1	0	1
transcriptional regulator ERG isoform 3	2	0	0	2
huntingtin isoform 2	4	0	0	4
ubiquitin-conjugating enzyme E2 N	0	1	0	1
nuclear factor NF-kappa-B p105 subunit isoform 1	3	0	1	4
protein AF-9 isoform a	0	0	0	1
melanocortin receptor 4	0	1	0	1
CAAX prenyl protease	0	0	0	1
urokinase-type plasminogen activator precursor	6	0	0	6
plasminogen precursor	6	0	0	6
bcl-2-related protein A1	0	2	0	2
urokinase plasminogen activator surface receptor precursor	6	0	0	6
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform a	0	1	0	1
glycogen synthase kinase-3 alpha	0	0	0	1
hexokinase HKDC1	0	1	0	1
DNA repair protein RAD52 homolog isoform a	0	0	0	1
bcl-2-like protein 11 isoform 1	0	0	2	2
Synaptojanin-2	0	1	0	1
Solute carrier family 22 member 2	0	3	0	3
Solute carrier family 22 member 1	0	9	0	10
Synaptojanin-1	0	1	0	1
Solute carrier family 22 member 3	0	1	0	1
Glutathione reductase, mitochondrial	0	3	0	4
72 kDa type IV collagenase	0	2	0	2
Matrix metalloproteinase-9	0	2	0	2
Alpha-synuclein	3	1	0	4
Peroxisomal N(1)-acetyl-spermine/spermidine oxidase	0	1	0	1
Multidrug and toxin extrusion protein 2	0	2	0	2
Rap guanine nucleotide exchange factor 4	4	0	0	4
Multidrug and toxin extrusion protein 1	0	5	0	5
Spermine oxidase	0	1	0	1
Choline O-acetyltransferase	0	1	0	1
Histone acetyltransferase p300	0	1	0	1
Histone acetyltransferase KAT2B	0	1	0	1
Histone acetyltransferase KAT5	0	1	0	1
Sodium- and chloride-dependent creatine transporter 1	0	1	0	1
Deoxycytidine kinase	0	0	0	1
Glutathione S-transferase P	0	1	0	1
Alpha-tocopherol transfer protein	0	0	1	1
Thymidine kinase 2	0	2	0	2
Deoxycytidine kinase	0	1	0	3
Probable deoxycytidylate deaminase	0	0	0	1
AAA family ATPase	0	0	0	1
Thymidine kinase, cytosolic	0	6	0	11
AAA family ATPase	0	0	0	1
Sterol O-acyltransferase 1	0	2	0	2
NPC intracellular cholesterol transporter 1 precursor	4	0	0	4
ras-related protein Rab-9A	6	0	0	6
serine/threonine-protein kinase mTOR isoform 1	6	0	0	6
Amyloid-beta precursor protein	1	3	1	5
Single-stranded DNA cytosine deaminase	1	0	0	1
Alpha-1B adrenergic receptor	0	0	1	1
Alpha-2A adrenergic receptor	0	4	4	9
Alpha-1B adrenergic receptor	0	5	1	6
Alpha-1A adrenergic receptor	0	1	1	2
Alpha-2C adrenergic receptor	0	4	3	8
Alpha-2B adrenergic receptor	0	2	1	3
Alpha-2C adrenergic receptor	0	2	1	3
Alpha-2A adrenergic receptor	0	2	1	3
Alpha-1D adrenergic receptor	0	4	1	5
Alpha-1D adrenergic receptor	0	3	1	5
Alpha-1A adrenergic receptor	0	6	1	7
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial	0	1	0	1
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial	0	1	0	1
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial	0	1	0	1
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial	0	1	0	1
bromodomain adjacent to zinc finger domain 2B	10	0	0	10
Chain A, POL POLYPROTEIN	0	1	0	1
Chain A, POL POLYPROTEIN	0	1	0	1
Chain B, POL POLYPROTEIN	0	1	0	1
Chain A, POL POLYPROTEIN	0	1	0	1
Chain B, POL POLYPROTEIN	0	1	0	1
Chain A, Pol Polyprotein	0	1	0	1
Chain B, Pol Polyprotein	0	1	0	1
PPM1D protein	6	0	0	6
neuropeptide S receptor isoform A	3	0	0	3
Prothrombin	0	2	0	2
Gag-Pol polyprotein	0	4	0	4
Gag-Pol polyprotein	0	2	0	2
Acetylcholinesterase	0	1	0	3
Cannabinoid receptor 1	0	3	0	3
Microsomal triglyceride transfer protein large subunit	0	2	0	2
Disintegrin and metalloproteinase domain-containing protein 17	0	3	0	3
Envelope glycoprotein gp160 [Cleaved into: Surface protein gp120	0	1	0	1
Protease	0	2	1	4
Fructose-1,6-bisphosphatase 1	0	0	0	2
Reverse transcriptase	0	2	2	4
Cholesterol 24-hydroxylase	0	0	1	1
Type IV secretion-like conjugative transfer relaxase protein TraI	0	1	0	1
Nuclear receptor subfamily 1 group I member 2	0	0	3	3
D(2) dopamine receptor	0	4	1	5
Amine oxidase [flavin-containing] A	0	2	0	2
D(4) dopamine receptor	0	2	0	2
Amine oxidase [flavin-containing] B	0	2	0	2
Kappa-type opioid receptor	0	4	1	6
Histamine H1 receptor	0	3	0	3
D(3) dopamine receptor	0	3	0	3
Mu-type opioid receptor	0	3	1	6
Potassium voltage-gated channel subfamily H member 2	0	8	0	8
Chain A, Dihydrofolate reductase	0	0	1	1
lysosomal alpha-glucosidase preproprotein	4	0	0	4
DNA polymerase beta	7	0	0	7
Thymidylate synthase	0	5	0	5
Thymidylate synthase	0	2	0	3
Dihydrofolate reductase	0	3	1	4
Aldo-keto reductase family 1 member B1	0	3	0	3
Folylpolyglutamate synthase, mitochondrial	0	0	0	1
Solute carrier organic anion transporter family member 1A3	0	2	0	3
Folylpolyglutamate synthase, mitochondrial	0	0	0	1
Multidrug resistance associated protein	0	0	0	1
Beta-galactosidase	0	1	0	1
Lipopolysaccharide heptosyltransferase 1	0	1	0	1
PA-I galactophilic lectin	0	0	1	1
Jacalin	0	0	1	1
Chain A, GLUTAMATE RECEPTOR SUBUNIT 2	0	1	0	1
Chain A, Glutamate Receptor Subunit 2	0	1	0	1
Chain B, Glutamate Receptor Subunit 2	0	1	0	1
Chain A, Slr1257 protein	0	0	1	1
Chain A, Glucosamine--fructose-6-phosphate aminotransferase [isomerizing]	0	1	0	1
beta-2 adrenergic receptor	1	0	0	1
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	6	0	0	6
Metabotropic glutamate receptor 8	0	2	0	2
Metabotropic glutamate receptor 6	0	1	2	4
Excitatory amino acid transporter 4	0	1	0	1
Bifunctional aspartokinase/homoserine dehydrogenase 1	0	1	0	1
ATP-citrate synthase	0	1	0	1
Glutamate receptor 1	1	4	2	7
Glutamate receptor 3	1	4	2	7
Glutamate receptor 4	1	4	2	7
Glutamate receptor ionotropic, kainate 1	0	4	2	6
Metabotropic glutamate receptor 1	0	2	1	3
Metabotropic glutamate receptor 2	0	0	1	1
Metabotropic glutamate receptor 3	0	0	1	1
Metabotropic glutamate receptor 4	0	1	1	2
Metabotropic glutamate receptor 5	0	1	1	2
Metabotropic glutamate receptor 6	0	0	1	1
Metabotropic glutamate receptor 7	0	0	1	1
Glutamate receptor ionotropic, kainate 1	0	3	2	5
Metabotropic glutamate receptor 5	0	1	2	4
Glutamate receptor ionotropic, kainate 2	0	4	3	7
Glutamate receptor 1	0	3	2	5
Glutamate receptor 2	0	3	2	5
Glutamate receptor 3	0	1	2	3
Glutamate receptor ionotropic, kainate 3	0	4	0	4
Excitatory amino acid transporter 1	0	2	0	3
Excitatory amino acid transporter 2	0	2	0	3
Excitatory amino acid transporter 3	0	2	0	3
Metabotropic glutamate receptor 8	0	0	1	1
Glutamate receptor 4	0	3	1	4
Excitatory amino acid transporter 3	0	0	0	1
Glutamate racemase	0	0	0	1
Metabotropic glutamate receptor 8	0	1	1	2
Glutamate receptor ionotropic, NMDA 2A	0	8	3	12
Glutamate receptor ionotropic, NMDA 2C	0	8	3	12
Glutamate receptor ionotropic, kainate 4	0	4	0	4
Glutamate carboxypeptidase 2	0	1	0	1
Glutamate receptor ionotropic, kainate 2	0	3	2	5
Glutamate receptor ionotropic, kainate 3	0	3	0	3
Metabotropic glutamate receptor 1	0	1	1	3
Metabotropic glutamate receptor 2	0	1	1	3
Metabotropic glutamate receptor 7	0	1	1	3
Metabotropic glutamate receptor 3	0	1	1	3
Metabotropic glutamate receptor 4	0	1	1	3
Glutamate receptor ionotropic, kainate 5	0	3	0	3
Glutamate receptor ionotropic, NMDA 2D	0	8	3	12
Glutamate receptor ionotropic, kainate 5	0	4	0	4
Glutamate racemase	0	0	0	1
Prolyl 4-hydroxylase	0	3	0	3
Glutamate receptor ionotropic, NMDA 3B	0	8	3	12
Alpha-ketoglutarate-dependent dioxygenase FTO	0	3	0	3
Glutamate receptor ionotropic, NMDA 3A	0	8	3	12
Chain A, Glutamine Binding Protein	0	0	1	1
Asc-type amino acid transporter 1	0	1	0	1
Chain B, EUKARYOTIC TRANSLATION INITIATION FACTOR 4E	0	0	1	1
Glycine receptor subunit alpha-1	0	0	2	2
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Sodium- and chloride-dependent glycine transporter 1	0	1	0	1
Large neutral amino acids transporter small subunit 1	0	5	0	5
Serine racemase	0	1	0	1
Olfactory receptor 51E2	0	0	1	1
Sodium- and chloride-dependent glycine transporter 2	0	1	0	1
Hypoxanthine-guanine phosphoribosyltransferase	0	0	0	1
Ricin	0	1	0	1
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase	0	0	1	1
Purine nucleoside phosphorylase	0	0	1	2
Shiga toxin subunit A	0	1	0	1
Chain A, ELONGATION FACTOR TU (EF-TU)	0	0	1	1
Chain A, Elongation Factor G	0	0	1	1
Chain A, ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 3	0	0	1	1
Chain A, Eukaryotic peptide chain release factor GTP-binding subunit	0	0	1	1
Chain A, ras-related C3 botulinum toxin substrate 1 isoform Rac1b	0	0	1	1
Chain A, ras-related C3 botulinum toxin substrate 1 isoform Rac1b	0	0	1	1
Chain A, interferon-inducible GTPase	0	0	1	1
Chain A, interferon-inducible GTPase	0	0	1	1
Chain A, Elongation factor 2	0	0	1	1
Chain A, Guanine nucleotide-binding protein G(i), alpha-1 subunit	0	0	1	1
Matrilysin	0	2	0	2
Ras-related protein Rab-7a	0	0	2	2
4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT6	0	1	0	1
4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT5	0	1	0	1
Alpha-(1,3)-fucosyltransferase 7	0	1	0	1
CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1	0	1	0	1
4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase 9	0	4	0	4
Chain A, Uracil Phosphoribosyltransferase	0	0	1	1
Chain B, Uracil Phosphoribosyltransferase	0	0	1	1
Chain C, Uracil Phosphoribosyltransferase	0	0	1	1
Chain E, Fibrin beta chain	0	1	0	1
Chain A, RNA-directed RNA polymerase NS5	0	1	0	1
WRN	1	0	0	1
Mcl-1	0	1	0	1
MPI protein	0	1	0	1
Cyclin-dependent kinase 5, regulatory subunit 1 (p35)	0	0	0	1
alkaline phosphatase, intestinal	0	0	1	1
luciferase	1	0	0	1
pyruvate kinase	2	0	0	2
glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase	0	1	0	1
CDK5	0	0	0	1
serine-protein kinase ATM isoform a	2	0	0	2
major prion protein preproprotein Prp precursor	0	1	0	1
alkaline phosphatase, tissue-nonspecific isozyme isoform 1 preproprotein	0	0	1	1
glucose-6-phosphate 1-dehydrogenase isoform b	0	1	0	1
intestinal alkaline phosphatase precursor	0	0	1	1
serine/threonine-protein kinase PLK1	4	0	0	4
DNA polymerase eta isoform 1	1	0	0	1
Vif	0	3	0	3
Tat	0	2	0	2
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	1	3	0	4
alkaline phosphatase, germ cell type preproprotein	0	0	1	1
endoribonuclease toxin MazF	0	0	1	1
DNA dC->dU-editing enzyme APOBEC-3F isoform a	1	0	0	1
Pyruvate kinase PKM	0	1	1	2
Endothelin receptor type B	2	0	0	2
Endothelin-1 receptor	2	0	0	2
phosphoglycerate kinase	1	0	0	1
hypothetical protein CAALFM_CR05890CA	0	0	0	1
H3 histone acetyltransferase	0	0	0	1
large T antigen	0	2	0	2
Chain A, HISTIDINE-BINDING PROTEIN	0	0	1	1
Plasma kallikrein	0	0	0	1
Histidine-binding periplasmic protein	0	0	1	1
Hsf1 protein	0	0	2	2
Cytochrome P450 2J2	0	5	0	5
NAD-dependent protein deacetylase sirtuin-2	0	3	1	4
NAD-dependent protein deacetylase	0	2	0	2
Chain A, membrane-associated prostaglandin E synthase-2	0	1	0	1
Prostaglandin E synthase	0	1	0	1
3',5'-cyclic-AMP phosphodiesterase	0	1	0	1
Solute carrier organic anion transporter family member 2B1	0	4	0	5
Cytochrome c oxidase subunit 2	0	1	0	1
Phospholipase A2, major isoenzyme	0	1	0	1
Procathepsin L	0	1	1	2
Interleukin-8	0	1	0	1
Androgen receptor	0	0	1	1
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	2
Aldo-keto reductase family 1 member B1	0	1	0	1
Aldo-keto reductase family 1 member C4	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Sodium-dependent dopamine transporter	0	2	0	2
Sodium- and chloride-dependent GABA transporter 1	0	2	0	2
Thromboxane-A synthase	0	1	0	1
Indoleamine 2,3-dioxygenase 1	0	2	0	2
Caspase-1	0	0	0	1
Prostaglandin E2 receptor EP3 subtype	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	2	0	2
Sodium- and chloride-dependent GABA transporter 3	0	2	0	2
Prostaglandin E2 receptor EP4 subtype	0	1	0	1
Multidrug resistance-associated protein 1	0	1	0	1
Bifunctional epoxide hydrolase 2	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
Prostaglandin E2 receptor EP1 subtype	0	1	0	1
Aldo-keto reductase family 1 member C3	0	3	0	3
Sodium- and chloride-dependent betaine transporter	0	2	0	2
C-X-C chemokine receptor type 3	0	1	0	1
Aldo-keto reductase family 1 member C2	0	1	0	1
Prostaglandin D2 receptor	0	2	0	2
Lactoylglutathione lyase	0	1	0	1
Aldo-keto reductase family 1 member C1	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	2
Uracil nucleotide/cysteinyl leukotriene receptor	0	1	0	1
Solute carrier family 22 member 7	0	1	0	4
Prostaglandin E2 receptor EP2 subtype	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Dehydrogenase/reductase SDR family member 9	0	1	0	1
Solute carrier organic anion transporter family member 1B3	0	4	0	4
Cytosolic phospholipase A2 gamma	0	1	0	1
Prostaglandin D2 receptor 2	0	1	1	2
Solute carrier organic anion transporter family member 1B1	0	6	0	7
Chain A, Glutamate receptor 2	0	0	1	1
Chain A, Glutamate receptor 2	0	0	1	1
Chain C, Glutamate receptor 2	0	0	1	1
endonuclease IV	3	0	0	3
Glutamate receptor ionotropic, kainate 4	0	1	0	1
Acetylcholinesterase	0	5	0	5
Sodium channel protein type 4 subunit alpha	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1F	0	4	0	4
Voltage-dependent L-type calcium channel subunit alpha-1D	0	4	0	4
Voltage-dependent L-type calcium channel subunit alpha-1S	0	4	0	4
Voltage-dependent L-type calcium channel subunit alpha-1C	0	6	0	6
Chain A, AMINOPEPTIDASE	0	1	0	1
Chain A, AMINOPEPTIDASE	0	1	0	1
Chain A, Leucine Aminopeptidase	0	1	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	1	0	1
Intestinal-type alkaline phosphatase	0	1	0	1
Phospholipase A-2-activating protein	0	1	0	1
Sterol O-acyltransferase 1	0	2	0	2
Trypsin	0	2	0	2
Fatty acid-binding protein, heart	0	2	0	2
Coagulation factor VII	0	3	0	3
Aromatase	0	5	0	5
Tissue factor	0	4	0	4
Fatty acid-binding protein, adipocyte	0	4	0	4
Tyrosine-protein phosphatase non-receptor type 7	0	1	0	1
Sterol O-acyltransferase 1	0	2	0	2
Nuclear receptor subfamily 4 group A member 2	0	0	3	3
Dual specificity protein phosphatase 3	0	1	0	1
Fatty acid-binding protein 5	0	2	0	2
Chain A, Antigen Cd11a (p180)	0	1	0	1
Smad3	4	0	0	4
isocitrate dehydrogenase 1, partial	1	0	0	1
3-hydroxy-3-methylglutaryl-coenzyme A reductase	0	6	0	6
Integrin beta-2	0	1	0	1
Intercellular adhesion molecule 1	0	1	0	1
Aldo-keto reductase family 1 member B1	0	7	0	7
Neutrophil elastase	0	2	0	2
Insulin receptor	0	3	0	3
Integrin alpha-L	0	1	1	2
Substance-K receptor	0	2	0	2
Sodium-dependent noradrenaline transporter	0	6	1	7
3-hydroxy-3-methylglutaryl-coenzyme A reductase	0	4	0	4
Sodium-dependent dopamine transporter	0	2	0	2
Lanosterol 14-alpha demethylase	0	1	0	1
Acyl-CoA:cholesterol acyltransferase	0	1	0	1
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	3	0	0	3
Methyl-accepting chemotaxis protein NahY	0	0	2	2
Carnitine O-palmitoyltransferase 1, muscle isoform	0	1	0	1
ClpP	2	0	0	2
Cytochrome P450 1A1	0	2	0	2
Cytochrome P450 1A2	0	1	0	1
Cholinesterase	0	4	0	4
Cytochrome P450 2C11	0	1	0	1
Ribosyldihydronicotinamide dehydrogenase [quinone]	0	4	1	5
Acetylcholinesterase	0	2	0	2
Nociceptin receptor	0	1	0	1
Melatonin receptor type 1A	0	2	1	3
Melatonin receptor type 1C	0	0	1	1
Melatonin receptor type 1A	0	1	1	2
Melatonin receptor type 1B	0	2	1	3
Melatonin receptor type 1C	0	1	1	2
Melatonin receptor type 1B	0	1	1	2
Nuclear factor erythroid 2-related factor 2	0	0	1	3
Cytochrome P450 1B1	0	3	0	3
Palmitoleoyl-protein carboxylesterase NOTUM	0	1	0	1
Carboxylic ester hydrolase	0	2	0	2
Histamine H3 receptor	0	2	0	2
Dihydrofolate reductase	0	5	0	5
Solute carrier family 22 member 1	0	1	0	2
Serine racemase	0	1	0	1
nonstructural protein 1	5	0	0	5
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Beta-1 adrenergic receptor	0	1	2	4
Beta-1 adrenergic receptor	0	4	2	7
Beta-2 adrenergic receptor	0	2	2	5
ATP-dependent translocase ABCB1	0	2	0	2
UDP-glucuronosyltransferase 2B7	0	2	0	4
UDP-glucuronosyltransferase 1-6	0	1	0	2
ATP-dependent translocase ABCB1	0	2	0	2
UDP-glucuronosyltransferase 1A1	0	1	0	1
UDP-glucuronosyltransferase 1A4	0	1	0	1
UDP-glucuronosyltransferase 2B10	0	1	0	1
Stromelysin-1	0	1	0	1
Multidrug transporter MdfA	0	1	0	1
Protein-arginine deiminase type-4	0	3	0	3
Opioid receptor, delta 1b	0	1	0	1
Opioid receptor homologue	0	1	0	1
Acyl-CoA desaturase 1	0	2	0	2
Histidine decarboxylase	0	0	1	1
Proteinase-activated receptor 1	0	1	1	2
Kappa-type opioid receptor	0	2	1	4
UDP-glucuronosyltransferase 1A3	0	0	0	1
Nociceptin receptor	0	1	0	1
5-hydroxytryptamine receptor 7	0	3	0	3
Mu-type opioid receptor	0	1	0	1
Mas-related G-protein coupled receptor member X2	0	0	1	1
Mu-type opioid receptor	0	1	0	1
Chain B, Exotoxin A	0	0	1	1
Chain B, Exotoxin A	0	0	1	1
Chain B, Exotoxin A	0	0	1	1
Chain B, Hiv-1 Reverse Transcriptase	0	1	0	1
Chain A, Hiv-1 Reverse Transcriptase	0	1	0	1
Chain A, Hiv-1 Reverse Transcriptase	0	1	0	1
Chain A, Hiv-1 Reverse Transcriptase	0	1	0	1
Chain B, Hiv-1 Reverse Transcriptase	0	1	0	1
Chain A, Reverse transcriptase/ribonuclease H	0	1	0	1
Gag-Pol polyprotein	0	1	0	1
Gag-Pol polyprotein	0	1	0	1
Imidazoleglycerol-phosphate dehydratase	0	1	0	1
Ryanodine receptor 1	0	1	0	1
Exoribonuclease H	0	1	0	1
Cardiac ryanodine receptor 2	0	1	0	1
Nitric oxide synthase, endothelial	0	1	0	1
Collagenase 3	0	1	0	1
Cholesteryl ester transfer protein	0	1	0	1
D-amino-acid oxidase	0	1	0	1
Hydroxycarboxylic acid receptor 3	0	0	1	1
Nicotinamidase	0	1	0	1
Hydroxycarboxylic acid receptor 2	0	0	1	1
D-aspartate oxidase	0	1	0	1
Hydroxycarboxylic acid receptor 2	0	1	1	2
Chain A, NAD-dependent deacetylase	0	1	0	1
Caspase-7	3	0	0	3
caspase-3	3	0	0	3
Poly [ADP-ribose] polymerase 2	0	1	0	1
NAD-dependent histone deacetylase SIR2	0	1	0	1
Poly [ADP-ribose] polymerase 1	0	1	0	1
Cytochrome P450 3A5	0	1	0	1
NAD-dependent protein deacetylase HST2	0	2	0	2
NAD(+) hydrolase SARM1	0	1	0	1
NAD-dependent protein deacetylase sirtuin-6	0	1	0	1
NAD-dependent protein deacetylase sirtuin-1	0	2	1	5
NAD-dependent protein deacetylase sirtuin-3, mitochondrial	0	1	1	2
Sodium/iodide cotransporter	0	1	0	1
Chain A, Adipocyte Lipid-binding Protein	0	0	1	1
Chain A, SERUM ALBUMIN	0	0	1	1
Chain A, SERUM ALBUMIN	0	0	1	1
Chain A, MUSCLE FATTY ACID BINDING PROTEIN	0	0	1	1
Chain A, MUSCLE FATTY ACID BINDING PROTEIN	0	0	1	1
Chain A, MUSCLE FATTY ACID BINDING PROTEIN	0	0	1	1
putative potassium channel subunit	0	0	1	1
Fatty-acid amide hydrolase 1	0	2	0	2
Fatty acid-binding protein, liver	0	0	1	1
DNA topoisomerase 1	0	1	0	1
Protein kinase C alpha type	0	1	1	3
Tyrosine-protein phosphatase non-receptor type 1	0	3	0	3
Transient receptor potential cation channel subfamily V member 2	0	1	0	1
Solute carrier family 2, facilitated glucose transporter member 9	0	1	1	2
Chain A, Thymidylate Synthase	0	1	0	1
Chain A, Thymidylate Synthase	0	1	0	1
Chain A, Thymidylate Synthase	0	1	0	1
Thymidylate synthase	0	1	0	1
Thymidylate synthase	0	1	0	1
tyrosine-protein kinase Yes	2	0	0	2
Dihydrofolate reductase	0	2	0	2
Dihydrofolate reductase	0	3	0	3
Thymidylate synthase	0	2	0	2
Folate receptor beta	0	1	0	1
Folate receptor alpha	0	1	0	1
Dihydrofolate reductase	0	3	0	4
Trifunctional purine biosynthetic protein adenosine-3	0	2	0	2
Serine hydroxymethyltransferase, cytosolic	0	1	1	2
Reduced folate transporter	0	1	0	1
Thymidylate synthase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	2	0	3
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Proton-coupled folate transporter	0	2	0	3
Retinoid isomerohydrolase	0	1	0	1
Retinoid isomerohydrolase	0	1	0	1
Retinoid isomerohydrolase	0	1	0	1
Solute carrier organic anion transporter family member 1A4	0	0	0	1
Solute carrier organic anion transporter family member 1A1	0	0	0	1
Canalicular multispecific organic anion transporter 1	0	1	0	2
Solute carrier family 22 member 11	0	1	0	2
Solute carrier family 22 member 8	0	1	0	2
Solute carrier family 22 member 7	0	1	0	2
heat shock protein HSP 90-alpha isoform 2	0	0	0	1
heat shock protein 90, putative	0	0	0	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
UDP-glucuronosyltransferase 1A9	0	0	0	2
Gamma-aminobutyric acid receptor subunit alpha-1	0	0	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	0	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	1	2
Gamma-aminobutyric acid receptor subunit beta-1	0	0	1	1
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-4	0	0	0	1
Gamma-aminobutyric acid receptor subunit gamma-2	0	0	0	1
5-hydroxytryptamine receptor 2C	0	6	1	7
Gamma-aminobutyric acid receptor subunit beta-3	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-5	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	0	1	1
5-hydroxytryptamine receptor 2B	0	8	1	9
Gamma-aminobutyric acid receptor subunit alpha-2	0	0	1	1
Gamma-aminobutyric acid receptor subunit beta-2	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	0	1	1
UDP-glucuronosyltransferase 1A8	0	0	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
5-hydroxytryptamine receptor 1A	0	2	2	4
Beta-2 adrenergic receptor	0	2	0	3
D(3) dopamine receptor	0	3	0	3
D(1A) dopamine receptor	0	3	1	4
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Endothelin-1 receptor	0	1	1	2
Beta-3 adrenergic receptor	0	2	0	2
5-hydroxytryptamine receptor 1B	0	2	1	3
5-hydroxytryptamine receptor 2A	0	4	1	5
Neuromedin-K receptor	0	0	1	1
Type-1 angiotensin II receptor	0	1	1	2
Cholecystokinin receptor type A	0	1	1	2
5-hydroxytryptamine receptor 7	0	2	1	3
Alpha-1A adrenergic receptor	0	3	2	6
Alpha-1B adrenergic receptor	0	1	1	3
Vasopressin V1a receptor	0	1	1	2
5-hydroxytryptamine receptor 6	0	5	1	6
Beta-2 adrenergic receptor	0	1	0	1
Sodium channel protein type 5 subunit alpha	0	3	0	3
Sodium/bile acid cotransporter	0	1	0	1
Nuclear receptor subfamily 2 group E member 1	0	0	2	2
NADH-cytochrome b5 reductase 3	0	1	0	1
Thyroid peroxidase	0	1	0	1
Taste receptor type 2 member 38	0	0	1	2
Chain A, dATP pyrophosphohydrolase	0	1	0	1
Chain A, Adenylate cyclase type 5	0	1	0	1
Chain B, Adenylate cyclase type 2	0	1	0	1
Monocarboxylate transporter 4	0	0	0	1
Monocarboxylate transporter 2	0	0	0	1
Monocarboxylate transporter 1	0	0	0	1
C-terminal-binding protein 2	0	1	0	1
Monocarboxylate transporter 2	0	1	0	1
Solute carrier organic anion transporter family member 2A1	0	1	0	1
Chain A, Troponin C, slow skeletal and cardiac muscles	0	0	1	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
BRCA1	1	0	0	1
P53	1	0	0	1
M18 aspartyl aminopeptidase	0	1	0	1
cathepsin L1	0	1	0	1
hexokinase-4 isoform 1	1	0	0	1
glucokinase regulatory protein	1	0	0	1
atrial natriuretic peptide receptor 2 precursor	3	0	0	3
FAD-linked sulfhydryl oxidase ALR	0	0	0	1
transcription factor p65 isoform 1	0	0	1	1
serine/threonine-protein kinase 33 isoform a	0	0	1	1
POsterior Segregation	0	0	1	1
Aryl hydrocarbon receptor	0	1	0	1
Estrogen receptor beta	0	0	1	1
Lysine-specific histone demethylase 1A	0	1	0	1
Transient receptor potential cation channel subfamily A member 1	0	1	1	2
Tyrosine-protein kinase ABL1	0	1	0	2
Myc proto-oncogene protein	0	1	0	2
Transthyretin	0	0	1	1
Estrogen receptor	0	1	0	1
Tyrosine-protein kinase Lck	0	1	0	1
Cathepsin D	0	1	0	1
Luciferin 4-monooxygenase	0	1	0	1
DNA polymerase alpha catalytic subunit	0	1	0	1
Breakpoint cluster region protein	0	1	0	2
Tyrosinase	0	2	0	2
Ornithine decarboxylase	0	1	0	1
Estrogen receptor	0	0	1	1
Nuclear factor NF-kappa-B p105 subunit	0	1	0	1
Sucrase-isomaltase, intestinal	0	1	0	1
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1	0	1	0	1
Alpha-glucosidase MAL12	0	1	0	1
Nuclear factor NF-kappa-B p100 subunit	0	1	0	1
Transcription factor p65	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	0	0	1
Bcl-2-like protein 1	0	1	0	1
Serine/threonine-protein kinase PAK 1	0	1	0	1
N1L	0	1	0	1
NAD(P)H dehydrogenase [quinone] 1	0	0	0	2
Tubulin beta-2B chain	0	1	0	1
Lysosomal alpha-glucosidase	0	1	0	1
Transient receptor potential cation channel subfamily A member 1	0	1	0	1
Similar to alpha-tubulin isoform 1	0	1	0	1
Similar to alpha-tubulin isoform 1	0	1	0	1
Prenyltransferase homolog	0	0	0	1
Zinc finger protein mex-5	0	0	1	1
NS5	0	0	1	1
Spike glycoprotein	0	0	1	1
Replicase polyprotein 1ab	0	0	1	1
Transmembrane protease serine 2	0	0	1	1
Polymerase basic protein 2	0	0	1	1
RNA-directed RNA polymerase catalytic subunit	0	0	1	1
Polymerase acidic protein	0	0	1	1
Replicase polyprotein 1a	0	0	1	1
Replicase polyprotein 1ab	0	0	1	1
Adenosine receptor A1	0	1	0	1
Genome polyprotein	0	0	1	1
Chain A, 6,7-Dimethyl-8-ribityllumazine Synthase	0	0	1	1
Chain B, 6,7-Dimethyl-8-ribityllumazine Synthase	0	0	1	1
Chain A, Breast cancer type 1 susceptibility protein	1	0	0	1
Chain H, Immunoglobulin Igg1 Heavy chain	0	0	1	1
Chain L, Immunoglobulin Igg1 Lambda Light Chain	0	0	1	1
Chain A, DODECIN	0	0	1	1
Chain A, DODECIN	0	0	1	1
Chain C, DODECIN	0	0	1	1
Chain E, DODECIN	0	0	1	1
tumor necrosis factor	1	0	0	1
Riboflavin-binding protein	0	1	1	2
60 kDa chaperonin	0	2	0	2
60 kDa heat shock protein, mitochondrial	0	2	0	2
Caspase-7	1	0	0	1
10 kDa heat shock protein, mitochondrial	0	2	0	2
Thiosulfate sulfurtransferase	0	2	0	2
60 kDa chaperonin	0	2	0	2
10 kDa chaperonin	0	2	0	2
Butyrophilin subfamily 3 member A1	0	0	1	1
4-hydroxy-3-methylbut-2-enyl diphosphate reductase	0	1	0	1
Geranylgeranyl pyrophosphate synthase	0	2	0	2
Farnesyl pyrophosphate synthase	0	2	0	2
Farnesyl pyrophosphate synthase	0	2	0	2
Farnesyl diphosphate synthase	0	1	0	1
Farnesyl pyrophosphate synthase	0	1	0	1
H	0	1	0	1
Phosphotransferase	0	1	0	1
Farnesyl diphosphate synthase	0	1	0	1
Albumin	0	0	1	1
D	0	1	0	1
Histamine H2 receptor	0	2	0	2
Histamine H1 receptor	0	1	0	1
5-hydroxytryptamine receptor 2C	0	1	0	1
5-hydroxytryptamine receptor 2A	0	1	0	1
D(2) dopamine receptor	0	1	0	1
5-hydroxytryptamine receptor 2B	0	1	0	1
Transporter	0	1	0	1
5-hydroxytryptamine receptor 1A	0	1	0	1
Nuclear receptor subfamily 3 group C member 3	0	2	0	2
Transporter	0	1	0	1
Acetylcholinesterase	0	1	0	1
Acetylcholine receptor subunit epsilon	0	1	0	1
Amine oxidase [flavin-containing] B	0	1	0	1
Acetylcholinesterase	0	3	0	3
Cholinesterase	0	1	0	1
Tyrosine-protein kinase SYK	0	1	0	1
Beta-secretase 1	0	1	0	1
Cholinesterase	0	1	0	1
Carboxylic ester hydrolase	0	1	0	1
atrial natriuretic peptide receptor 1 precursor	2	0	0	2
Pancreatic triacylglycerol lipase	0	1	0	1
NADH-ubiquinone oxidoreductase chain 1	0	1	0	1
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial	0	1	0	1
Dihydroorotate dehydrogenase (fumarate)	0	1	0	1
Acyl carrier protein, mitochondrial	0	1	0	1
Dihydroorotate dehydrogenase	0	1	0	1
Met repressor	0	0	2	2
Protein arginine N-methyltransferase 5	0	0	1	1
Histone H3K27 methylase	0	0	0	1
Phenylethanolamine N-methyltransferase	0	0	1	2
S-adenosylmethionine decarboxylase proenzyme	0	1	0	2
Protein-L-isoaspartate(D-aspartate) O-methyltransferase	0	1	0	1
Catechol O-methyltransferase	0	0	0	1
Protein arginine N-methyltransferase 1	0	2	0	2
Methylosome protein 50	0	0	1	1
photoreceptor-specific nuclear receptor	0	1	0	1
transactivating tegument protein VP16 [Human herpesvirus 1]	0	1	0	1
3-hydroxy-3-methylglutaryl-coenzyme A reductase	0	1	0	1
exodeoxyribonuclease V subunit RecD	0	1	0	1
exodeoxyribonuclease V subunit RecB	0	1	0	1
exodeoxyribonuclease V subunit RecC	0	1	0	1
Thymidine kinase, cytosolic	0	1	0	4
Chain A, Protein (aspartate Aminotransferase)	0	0	1	1
Chain A, Aspartate Aminotransferase	0	0	1	1
Lysine-specific demethylase 4E	0	1	0	1
N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase	0	1	0	1
NADP-dependent malic enzyme, mitochondrial	0	0	0	1
Solute carrier family 13 member 3	0	1	0	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
ATP-dependent 6-phosphofructokinase	0	1	0	1
Ectonucleoside triphosphate diphosphohydrolase 2	0	1	0	1
Serine/threonine-protein kinase D3	0	1	0	1
Protein kinase C gamma type	0	1	0	1
Protein kinase C beta type	0	2	0	2
Cathepsin B	0	1	0	1
Protein kinase C eta type	0	1	0	1
Protein kinase C iota type	0	1	0	1
P2X purinoceptor 2	0	1	1	2
P2Y purinoceptor 4	0	0	1	1
DNA-dependent protein kinase catalytic subunit	0	1	0	1
Ectonucleoside triphosphate diphosphohydrolase 1	0	1	0	1
DNA primase	0	1	0	1
Protein kinase C epsilon type	0	2	0	2
Protein kinase C theta type	0	1	0	1
Protein kinase C zeta type	0	1	0	1
Protein kinase C delta type	0	1	0	1
Serine/threonine-protein kinase D1	0	1	0	1
Dual specificity protein phosphatase 5	0	1	0	1
Ectonucleoside triphosphate diphosphohydrolase 8	0	1	0	1
RmtA	0	1	0	1
Ectonucleoside triphosphate diphosphohydrolase 3	0	1	0	1
P2X purinoceptor 7	0	0	1	1
Sodium- and chloride-dependent taurine transporter	0	1	0	1
Potassium voltage-gated channel subfamily E member 1	0	1	0	1
Potassium voltage-gated channel subfamily KQT member 1	0	1	0	1
DNA polymerase III, partial	1	0	0	1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	0	1	0	1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	0	1	1	2
Chain A, ykoF	0	0	1	1
Chain B, ykoF	0	0	1	1
Chain A, ThiT	0	0	1	1
Thiamine transporter ThiT	0	0	1	1
Transketolase	0	0	1	1
Thiamine-binding periplasmic protein	0	0	1	1
Solute carrier family 22 member 2	0	1	0	1
Ubiquitin-like modifier activating enzyme 2	0	1	0	1
SUMO1 activating enzyme subunit 1	0	1	0	1
hexokinase	0	1	0	1
SUMO-conjugating enzyme UBC9	0	1	0	1
eukaryotic translation initiation factor 4 gamma 1 isoform 4	0	1	0	1
eukaryotic translation initiation factor 4E isoform 1	0	1	0	1
bifunctional UDP-N-acetylglucosamine pyrophosphorylase/glucosamine-1-phosphate N-acetyltransferase	0	1	0	1
Thymidine kinase	0	1	0	2
Thymidine kinase	0	1	0	2
Thymidine phosphorylase	0	0	0	1
Glucose-6-phosphate 1-dehydrogenase	0	1	0	1
Thymidylate kinase	0	1	0	1
Thymidine kinase	0	0	0	1
Thymidylate kinase	0	2	0	2
Thymidine kinase	0	2	0	4
Thymidine kinase	0	1	0	3
Thymidine kinase	0	0	0	1
Thymidine phosphorylase	0	1	0	1
Chain A, Nuclear Receptor ROR-beta	0	1	0	1
Ornithine decarboxylase	0	0	0	1
Ornithine decarboxylase	0	0	0	1
Retinoic acid receptor alpha	0	2	2	7
Retinoic acid receptor beta	0	2	2	7
Retinoic acid receptor alpha	0	1	2	3
Retinoic acid receptor gamma	0	2	2	7
Retinoic acid receptor gamma	0	1	2	3
Retinoic acid receptor RXR-alpha	0	2	2	4
Retinoic acid receptor beta	0	1	2	3
Cellular retinoic acid-binding protein 2	0	0	1	1
Mitogen-activated protein kinase 1	0	1	0	1
Retinoic acid receptor RXR-alpha	0	1	2	3
Retinoic acid receptor RXR-beta	0	2	2	4
Retinoic acid receptor RXR-beta	0	1	2	3
Retinoic acid receptor RXR-gamma	0	1	2	3
Nuclear receptor ROR-alpha	0	1	0	1
Cellular retinoic acid-binding protein 1	0	1	0	2
Retinoic acid receptor RXR-gamma	0	2	2	4
Cellular retinoic acid-binding protein 1	0	0	1	1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	0	2	1	3
Indoleamine 2,3-dioxygenase 2	0	1	0	1
Nuclear receptor ROR-beta	0	1	0	1
Chain A, Dihydrofolate Reductase	0	0	1	1
Chain A, Dihydrofolate reductase	0	1	0	1
Chain A, dihydrofolate reductase (DHFR)	0	1	0	1
Chain A, Dihydrofolate reductase	0	1	0	1
Chain A, Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	2
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	2	0	2
Dihydrofolate reductase type 1	0	1	0	2
Dihydrofolate reductase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	2	0	2
Dihydrofolate reductase	0	1	0	1
NH(3)-dependent NAD(+) synthetase	0	1	0	1
Dihydrofolate reductase	0	2	0	2
Thymidylate synthase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	2	0	2
Dihydrofolate reductase type 1 from Tn4003	0	1	0	1
Dipeptidyl peptidase 4	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Trace amine-associated receptor 5	0	0	1	1
Dihydrofolate reductase	0	2	0	2
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	2
Dihydrofolate reductase	0	1	0	1
Chain A, Cytidine Deaminase	0	1	0	1
Protein cereblon	0	2	0	2
Uridine-cytidine kinase 1	0	0	0	1
Chain A, Arginase 1	0	1	0	1
Cocaine esterase	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
Aldo-keto reductase family 1 member B7	0	1	0	1
C-X-C chemokine receptor type 4	0	0	1	1
pyruvate kinase PKM isoform a	1	0	0	1
Ectonucleoside triphosphate diphosphohydrolase 1	0	0	0	1
DNA polymerase beta	0	1	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(6)

Research Excerpts

Overview

Treatment

Research

Studies (483)

Protein Targets (1,432)

Luft Disease

Synonyms(6)

Research Excerpts

Overview

Treatment

Research

Studies (483)

Drugs Studied (263)

Protein Targets (1,432)