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2-(4-(2,4-dichlorophenoxy)phenoxy)propionic acid

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

2-(4-(2,4-dichlorophenoxy)phenoxy)propionic acid is a chemical compound also known as **2,4-dichlorophenoxyacetic acid (2,4-D)**. It's a widely used **herbicide** and is **not** a propionic acid derivative.

Here's why it's important for research:

* **Agriculture:** 2,4-D is one of the most widely used herbicides globally. It's crucial for controlling broadleaf weeds in various crops, including cereals, soybeans, and cotton. Research focuses on:
* **Improving its efficacy:** Studies explore ways to enhance its weed control capabilities and reduce application rates for environmental sustainability.
* **Understanding its mode of action:** Scientists investigate how 2,4-D disrupts plant growth to develop new and more targeted herbicides.
* **Developing resistant crops:** Research aims to create crops that are tolerant to 2,4-D, allowing for more efficient weed management without harming the desired plants.
* **Environmental impact:** 2,4-D has been associated with some environmental concerns, including potential impacts on water quality and non-target organisms. Research focuses on:
* **Minimizing its environmental footprint:** Studies explore alternative formulations and application methods to reduce environmental risks.
* **Assessing its long-term effects:** Researchers investigate the persistence of 2,4-D in the environment and its potential for bioaccumulation.
* **Human health:** 2,4-D is considered relatively safe for human use at recommended application rates. However, research continues to investigate potential health risks, particularly long-term exposure.

**It's important to note that 2,4-D is a powerful chemical and should only be used according to label instructions and safety guidelines.**

**In summary, 2,4-D is an important research subject due to its widespread use in agriculture, its environmental implications, and ongoing efforts to understand its potential human health impacts.**

2-(4-(2,4-dichlorophenoxy)phenoxy)propionic acid: an herbicide; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

diclofop : A racemate composed of equimolar amounts of (R)- and (S)-diclofop. It is a metabolite of declofop-methyl and a postemergence herbicide used for the control of wild oats and annual weeds in wheat, barley, rye and broad-leaved crops. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

2-[4-(2,4-dichlorophenoxy)phenoxy]propanoic acid : An aromatic ether that is 2-(4-hydroxyphenoxy)propanoic acid in which the hydrogen of the hydroxy group at position 4 has been substituted by a 2,4-dichlorophenyl group. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID38687
CHEMBL ID2288781
CHEBI ID145406
CHEBI ID81909
SCHEMBL ID66474
MeSH IDM0522792

Synonyms (42)

Synonym
diclofop
methyl 2-(4-(2,4-dichlorophenyoxy)phenoxy)propanoate
brn 2338390
hoe 21079
diclofop acid
diclofop [ansi:bsi:iso]
2-(4-(2,4-dichlorophenoxy)phenoxy)propanoic acid
(rs)-2-(4-(2,4-dichlorophenoxy)phenoxy)propionic acid
caswell no. 328b
dichlorfop acid
propanoic acid, 2-(4-(2,4-dichlorophenoxy)phenoxy)-
2-[4-(2,4-dichlorophenoxy)phenoxy]propanoic acid
NCGC00164481-01
FT-0639674
CHEBI:145406
40843-25-2
C18716
unii-3ln56779kt
3ln56779kt ,
diclofop, (+/-)-
hoe-21079
2-(4-(2',4'-dichlorophenoxy)phenoxy)propionic acid
(+/-)-diclofop
diclofop [iso]
SCHEMBL66474
CHEMBL2288781
chebi:81909
2-[4'-(2,4-dichlorophenoxy)-phenoxy]-propionic acid
2-[4'-(2,4-dichlorophenoxy)-phenoxy]propionic acid
4-(2',4'-dichlorophenoxy)-alpha-phenoxy-propionic acid
AKOS024354406
2-[4-(2,4-dichlorophenoxy)phenoxy]propanoic acid #
DTXSID5041859
mfcd00152216
(+/-)-diclofop, analytical standard
hoe-021079
diclofop (free acid)
Q27155655
AMY14561
diclofop (free acid) 100 microg/ml in acetonitrile
2-(4-(2,4-dichlorophenoxy)phenoxy)propionic acid
1ST22082
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (4)

ClassDescription
aromatic etherAny ether in which the oxygen is attached to at least one aryl substituent.
dichlorobenzeneAny member of the class of chlorobenzenes carrying two chloro groups at unspecified positions.
monocarboxylic acidAn oxoacid containing a single carboxy group.
dietherA polyether in which the number of ether linkages is 2.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Research

Studies (11)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (18.18)29.6817
2010's9 (81.82)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.38

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.38 (24.57)
Research Supply Index2.48 (2.92)
Research Growth Index4.86 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.38)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other11 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]