marsupsin: structure given in first source; isolated from Pterocarpus marsupium; RN given for (-)-isomer [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
marsupsin : A member of the class of 1-benzofurans that is 1-benzofuran-3(2H)-one, substituted by hydroxy groups at positions 2 and 6, a 4-hydroxybenzyl group at position 2 and a methoxy group at position 4. Isolated from the heartwood of Pterocarpus marsupium, it exhibits antihyperglycemic and antihyperlipidemic activities. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]
| Flora | Rank | Flora Definition | Family | Family Definition |
|---|---|---|---|---|
| Pterocarpus | genus | A plant genus of the family FABACEAE. Members contain TRITERPENES.[MeSH] | Fabaceae | The large family of plants characterized by pods. Some are edible and some cause LATHYRISM or FAVISM and other forms of poisoning. Other species yield useful materials like gums from ACACIA and various LECTINS like PHYTOHEMAGGLUTININS from PHASEOLUS. Many of them harbor NITROGEN FIXATION bacteria on their roots. Many but not all species of beans belong to this family.[MeSH] |
| Pterocarpus marsupium | species | [no description available] | Fabaceae | The large family of plants characterized by pods. Some are edible and some cause LATHYRISM or FAVISM and other forms of poisoning. Other species yield useful materials like gums from ACACIA and various LECTINS like PHYTOHEMAGGLUTININS from PHASEOLUS. Many of them harbor NITROGEN FIXATION bacteria on their roots. Many but not all species of beans belong to this family.[MeSH] |
| ID Source | ID |
|---|---|
| PubMed CID | 134369 |
| CHEMBL ID | 512396 |
| CHEBI ID | 66680 |
| SCHEMBL ID | 4688877 |
| MeSH ID | M0221323 |
| Synonym |
|---|
| 3(2h)-benzofuranone, 2,6-dihydroxy-2-((4-hydroxyphenyl)methyl)-4-methoxy-, (-)- |
| marsupsin |
| LMPK12130076 |
| carpusin |
| 83889-80-9 |
| chebi:66680 , |
| CHEMBL512396 |
| carasinaurone |
| marsuosin |
| 2,6-dihydroxy-2-[(4-hydroxyphenyl)methyl]-4-methoxy-1-benzofuran-3-one |
| 2,6-dihydroxy-2-(4-hydroxybenzyl)-4-methoxy-1-benzofuran-3(2h)-one |
| (-)-2,6-dihydroxy-2-((4-hydroxyphenyl)methyl)-4-methoxy-3(2h)-benzofuranone |
| SCHEMBL4688877 |
| Q27135300 |
| 2,6-dihydroxy-2-[(4-hydroxyphenyl)methyl]-4-methoxy-1-benzofuran-3(2h)-one |
| DTXSID601004019 |
| Excerpt | Reference | Relevance |
|---|---|---|
| "The aim of this research was to formulate Marsupsin-phospholipid complex (M-P Complex) in attempt to increase the bioavailability of marsupsin and to characterize this new formulation along with its evaluation." | ( Preparation, characterization and evaluation of Marsupsin-phospholipid complex. Jain, AK; Parial, SD; Sharma, S; Sikarwar, MS, 2008) | 0.87 |
| Role | Description |
|---|---|
| metabolite | Any intermediate or product resulting from metabolism. The term 'metabolite' subsumes the classes commonly known as primary and secondary metabolites. |
| hypoglycemic agent | A drug which lowers the blood glucose level. |
| antilipemic drug | A substance used to treat hyperlipidemia (an excess of lipids in the blood). |
| [role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Class | Description |
|---|---|
| polyphenol | Members of the class of phenols that contain 2 or more benzene rings each of which is substituted by at least one hydroxy group. |
| aromatic ether | Any ether in which the oxygen is attached to at least one aryl substituent. |
| 1-benzofurans | A member of the class of benzofurans consisting of a 1-benzofuran skeleton and its substituted derivatives thereof. |
| [compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID339154 | Antihyperlipidemic activity in diet-induced hyperlipidemic rat model assessed as serum total cholesterol level at 40 mg/kg, po administered once daily in morning through gastric intubation for 14 days measured after 4 hrs of last dose | 1993 | Journal of natural products, Jul, Volume: 56, Issue:7 | Antihyperlipidemic effect of flavonoids from Pterocarpus marsupium. |
| AID640884 | Antioxidant activity assessed as DPPH free radical scavenging activity after 30 mins by microplate reader assay | 2012 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 22, Issue:2 | Antioxidative oligostilbenes from Caragana sinica. |
| AID403245 | Effect on nondiabetic rat assessed as blood glucose level per 100 mL at 20 mg/kg, po | 1997 | Journal of natural products, Jun, Volume: 60, Issue:6 | Antihyperglycemic activity of phenolics from Pterocarpus marsupium. |
| AID403247 | Decrease in body weight in nondiabetic rat | 1997 | Journal of natural products, Jun, Volume: 60, Issue:6 | Antihyperglycemic activity of phenolics from Pterocarpus marsupium. |
| AID339155 | Antihyperlipidemic activity in diet-induced hyperlipidemic rat model assessed as serum triglyceride level at 40 mg/kg, po administered once daily in morning through gastric intubation for 14 days measured after 4 hrs of last dose | 1993 | Journal of natural products, Jul, Volume: 56, Issue:7 | Antihyperlipidemic effect of flavonoids from Pterocarpus marsupium. |
| AID339158 | Antihyperlipidemic activity in diet-induced hyperlipidemic rat model assessed as serum VLDLC level at 40 mg/kg, po administered once daily in morning through gastric intubation for 14 days measured after 4 hrs of last dose | 1993 | Journal of natural products, Jul, Volume: 56, Issue:7 | Antihyperlipidemic effect of flavonoids from Pterocarpus marsupium. |
| AID339156 | Antihyperlipidemic activity in diet-induced hyperlipidemic rat model assessed as serum HDLC level at 40 mg/kg, po administered once daily in morning through gastric intubation for 14 days measured after 4 hrs of last dose | 1993 | Journal of natural products, Jul, Volume: 56, Issue:7 | Antihyperlipidemic effect of flavonoids from Pterocarpus marsupium. |
| AID356320 | Antioxidant activity assessed as DPPH radical scavenging activity | 2003 | Journal of natural products, Aug, Volume: 66, Issue:8 | Sulfemodin 8-O-beta-D-glucoside, a new sulfated anthraquinone glycoside, and antioxidant phenolic compounds from Rheum emodi. |
| AID339159 | Antihyperlipidemic activity in diet-induced hyperlipidemic rat model assessed as ratio of HDLC to serum total cholesterol level at 40 mg/kg, po administered once daily in morning through gastric intubation for 14 days measured after 4 hrs of last dose | 1993 | Journal of natural products, Jul, Volume: 56, Issue:7 | Antihyperlipidemic effect of flavonoids from Pterocarpus marsupium. |
| AID339157 | Antihyperlipidemic activity in diet-induced hyperlipidemic rat model assessed as serum LDLC level at 40 mg/kg, po administered once daily in morning through gastric intubation for 14 days measured after 4 hrs of last dose | 1993 | Journal of natural products, Jul, Volume: 56, Issue:7 | Antihyperlipidemic effect of flavonoids from Pterocarpus marsupium. |
| AID640885 | Antioxidant activity assessed as inhibition of lipid peroxidation | 2012 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 22, Issue:2 | Antioxidative oligostilbenes from Caragana sinica. |
| AID403243 | Antihyperglycemic activity in streptozotocin-induced nonfasted diabetic rat assessed as decrease in blood glucose level at 20 mg/kg, po administered for 3 days measured 1 hr after last dose | 1997 | Journal of natural products, Jun, Volume: 60, Issue:6 | Antihyperglycemic activity of phenolics from Pterocarpus marsupium. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (40.00) | 18.2507 |
| 2000's | 2 (40.00) | 29.6817 |
| 2010's | 1 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.
| This Compound (17.76) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 5 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||