A drug used to prevent nausea or vomiting. An antiemetic may act by a wide range of mechanisms: it might affect the medullary control centres (the vomiting centre and the chemoreceptive trigger zone) or affect the peripheral receptors.
| Member | Definition | Class |
|---|
| alosetron | A pyrido[4,3-b]indole compound having a 5-methyl-1H-imidazol-4-ylmethyl group at the 2-position. | alosetron |
| alosetron hydrochloride | The hydrochloride salt of alosetron. | alosetron hydrochloride |
| aprepitant | A morpholine-based antiemetic, which is or the prevention of acute and delayed nausea and vomiting associated with initial and repeat courses of highly emetogenic cancer chemotherapy. Aprepitant is a selective high-affinity antagonist of human substance P/neurokinin 1 (NK1) receptors. | aprepitant |
| benzquinamide | | benzquinamide |
| buclizine | An N-alkylpiperazine carrying (4-chlorophenyl)(phenyl)methyl and 4-tert-butylbenzyl groups. | buclizine |
| chlorpromazine | A substituted phenothiazine in which the ring nitrogen at position 10 is attached to C-3 of an N,N-dimethylpropanamine moiety. | chlorpromazine |
| cinnarizine | | cinnarizine |
| cyclizine | An N-alkylpiperazine in which one nitrogen of the piperazine ring is substituted by a methyl group, while the other is substituted by a diphenylmethyl group. | cyclizine |
| cyclizine hydrochloride | A hydrochloride salt consisting of equimolar amounts of cyclizine and hydrogen chloride. | cyclizine hydrochloride |
| diphenhydramine | An ether that is the benzhydryl ether of 2-(dimethylamino)ethanol. It is a H1-receptor antagonist used as a antipruritic and antitussive drug. | diphenhydramine |
| diphenhydramine hydrochloride | The hydrochloride salt of diphenhydramine. | diphenhydramine hydrochloride |
| diphenidol | A tertiary alcohol that is butan-1-ol substituted by two phenyl groups at position 1 and a piperidin-1-yl group at position 4. | diphenidol |
| domperidone | 1-[3-(Piperidin-1-yl)propyl]-1,3-dihydro-2H-benzimidazol-2-one in which the 4-position of the piperidine ring is substituted by a 5-chloro-1,3-dihydro-2H-benzimidazol-2-on-1-yl group. A dopamine antagonist, it is used as an antiemetic for the short-term treatment of nausea and vomiting, and to control gastrointestinal effects of dopaminergic drugs given in the management of parkinsonism. The free base is used in oral suspensions, while the maleate salt is used in tablet preparations. | domperidone |
| doxylamine | | doxylamine |
| droperidol | An organofluorine compound that is haloperidol in which the hydroxy group has been eliminated with the introduction of a double bond in the piperidine ring, and the 4-chlorophenyl group has been replaced by a benzimidazol-2-on-1-yl group. It is used in the management of chemotherapy-induced nausea and vomiting, and in conjunction with an opioid analgesic such as fentanyl to maintain the patient in a calm state of neuroleptanalgesia with indifference to surroundings but still able to cooperate with the surgeon. | droperidol |
| fk 1052 | An organic heterotricyclic compound that is 8,9-dihydropyrido[1,2-a]indol-6(7H)-one substituted by a (5-methyl-1H-imidazol-4-yl)methyl group at position 7R and a methyl group at position 10. It is a dual 5-HT3 and 5-HT4 receptors antagonist whose clinical development was terminated in phase II. It was being developed for the treatment of chemotherapy-induced emesis and irritable bowel syndrome. | fabesetron |
| fosaprepitant | A morpholine derivative that is the (1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl ether of (3-{[(2R,3S)-3-(4-fluorophenyl)-2-hydroxymorpholin-4-yl]methyl}-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl)phosphonic acid. | fosaprepitant |
| haloperidol | A compound composed of a central piperidine structure with hydroxy and p-chlorophenyl substituents at position 4 and an N-linked p-fluorobutyrophenone moiety. | haloperidol |
| levosulpiride | An optically active form of sulpiride having (S)-configuration. The active enantiomer of the racemic drug sulpiride. Selective D2-like dopamine antagonist (Ki values are ~ 0.015. ~ 0.013, 1, ~ 45 and ~ 77 muM at D2, D3, D4, D1 and D5 receptors respectively). | (S)-(-)-sulpiride |
| methylprednisolone | The 6alpha-stereoisomer of 6-methylprednisolone. | 6alpha-methylprednisolone |
| metoclopramide | A member of the class of benzamides resulting from the formal condensation of 4-amino-5-chloro-2-methoxybenzoic acid with the primary amino group of N,N-diethylethane-1,2-diamine. | metoclopramide |
| netupitant | A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoic acid with the secondary amino group of N-methyl-4-(2-methylphenyl)-6-(4-methylpiperazin-1-yl)pyridin-3-amine; an antiemetic used in combination with palonosetron hydrochloride (under the trade name Akynzeo) to treat nausea and vomiting in patients undergoing cancer chemotherapy. | netupitant |
| olanzapine | A benzodiazepine that is 10H-thieno[2,3-b][1,5]benzodiazepine substituted by a methyl group at position 2 and a 4-methylpiperazin-1-yl group at position 4. | olanzapine |
| pachypodol | A trimethoxyflavone that is quercetin in which the hydroxy groups at position 3, 7 and 3' are replaced by methoxy groups. It has been isolated from Combretum quadrangulare and Euodia elleryana. | pachypodol |
| palonosetron | An organic heterotricyclic compound that is an antiemetic used (as its hydrochloride salt) in combination with netupitant (under the trade name Akynzeo) to treat nausea and vomiting in patients undergoing cancer chemotherapy. | palonosetron |
| perphenazine | A phenothiazine derivative in which the phenothiazine tricycle carries a chloro substituent at the 2-position and a 3-[4-(2-hydroxyethyl)piperazin-1-yl]propyl group at N-10. | perphenazine |
| prochlorperazine | A member of the class of phenothiazines that is 10H-phenothiazine having a chloro substituent at the 2-position and a 3-(4-methylpiperazin-1-yl)propyl group at the N-10 position. | prochlorperazine |
| promazine | A phenothiazine deriative in which the phenothiazine tricycle has a 3-(dimethylaminopropyl) group at the N-10 position. | promazine |
| promethazine | A tertiary amine that is a substituted phenothiazine in which the ring nitrogen at position 10 is attached to C-3 of an N,N-dimethylpropan-2-amine moiety. | promethazine |
| promethazine hydrochloride | The hydrochloride salt of promethazine. | promethazine hydrochloride |
| propofol | A phenol resulting from the formal substitution of the hydrogen at the 2 position of 1,3-diisopropylbenzene by a hydroxy group. | propofol |
| rolapitant | An azaspiro compound that is 1,7-diazaspiro[4.5]decan-2-one carrying additional phenyl and 1-{[3,5-bis(trifluoromethyl)phenyl]ethoxy}methyl substituents at position 8. Used (in the form of the hydrochloride hydrate) for the prevention of delayed nausea and vomiting associated with initial and repeat courses of emetogenic cancer chemotherapy. | rolapitant |
| rs 25259-197 | A hydrochloride obtained by combining palonosetron with one molar equivalent of hydrogen chloride; an antiemetic used in combination with netupitant (under the trade name Akynzeo) to treat nausea and vomiting in patients undergoing cancer chemotherapy. | palonosetron hydrochloride |
| sulpiride | A member of the class of benzamides obtained from formal condensation between the carboxy group of 2-methoxy-5-sulfamoylbenzoic acid and the primary amino group of (1-ethylpyrrolidin-2-yl)methylamine. | sulpiride |
| thiethylperazine | A member of the class of phenothiazines that is perazine substituted by a ethylsulfanyl group at position 2. | thiethylperazine |
| trifluoperazine | A member of the class of phenothiazines that is phenothiazine having a trifluoromethyl subsitituent at the 2-position and a 3-(4-methylpiperazin-1-yl)propyl group at the N-10 position. | trifluoperazine |
| triflupromazine | A member of the class of phenothiazines that is 10H-phenothiazine having a trifluoromethyl subsitituent at the 2-position and a 3-(dimethylamino)propyl group at the N-10 position. | triflupromazine |
| trimethobenzamide | The amide obtained by formal condensation of 3,4,5-trihydroxybenzoic acid with 4-[2-(N,N-dimethylamino)ethoxy]benzylamine. It is used to prevent nausea and vomitting in humans. | trimethobenzamide |
| zingerone | A methyl ketone that is 4-phenylbutan-2-one in which the phenyl ring is substituted at positions 3 and 4 by methoxy and hydroxy groups respectively. The major pungent component in ginger. | zingerone |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| 15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1 | Homo sapiens (human) | Potency | 14.1254 | 1 | 1 |
| 15-lipoxygenase, partial | Homo sapiens (human) | Potency | 22.5358 | 1 | 2 |
| 67.9K protein | Vaccinia virus | Potency | 17.6321 | 2 | 15 |
| acetylcholinesterase | Homo sapiens (human) | Potency | 36.7111 | 3 | 15 |
| activating transcription factor 6 | Homo sapiens (human) | Potency | 10.7438 | 1 | 2 |
| aldehyde dehydrogenase 1 family, member A1 | Homo sapiens (human) | Potency | 35.0554 | 1 | 4 |
| alpha-galactosidase | Homo sapiens (human) | Potency | 28.1838 | 1 | 1 |
| Alpha-synuclein | Homo sapiens (human) | Potency | 4.0075 | 1 | 2 |
| apical membrane antigen 1, AMA1 | Plasmodium falciparum 3D7 | Potency | 19.5640 | 1 | 3 |
| AR protein | Homo sapiens (human) | Potency | 26.2926 | 10 | 72 |
| aryl hydrocarbon receptor | Homo sapiens (human) | Potency | 34.5398 | 2 | 8 |
| arylsulfatase A | Homo sapiens (human) | Potency | 7.3312 | 1 | 6 |
| ATAD5 protein, partial | Homo sapiens (human) | Potency | 20.0217 | 3 | 12 |
| Ataxin-2 | Homo sapiens (human) | Potency | 21.2052 | 2 | 13 |
| ATP-dependent phosphofructokinase | Trypanosoma brucei brucei TREU927 | Potency | 11.6498 | 2 | 10 |
| ATPase family AAA domain-containing protein 5 | Homo sapiens (human) | Potency | 32.1896 | 2 | 6 |
| atrial natriuretic peptide receptor 2 precursor | Homo sapiens (human) | Potency | 16.9463 | 1 | 7 |
| Bloom syndrome protein isoform 1 | Homo sapiens (human) | Potency | 39.6244 | 2 | 8 |
| bromodomain adjacent to zinc finger domain 2B | Homo sapiens (human) | Potency | 33.9761 | 1 | 5 |
| caspase 7, apoptosis-related cysteine protease | Homo sapiens (human) | Potency | 46.4884 | 1 | 7 |
| caspase-3 | Cricetulus griseus (Chinese hamster) | Potency | 33.4915 | 1 | 2 |
| caspase-3 | Homo sapiens (human) | Potency | 46.4884 | 1 | 7 |
| Caspase-7 | Cricetulus griseus (Chinese hamster) | Potency | 33.4915 | 1 | 2 |
| Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 33.8291 | 2 | 17 |
| cellular tumor antigen p53 isoform a | Homo sapiens (human) | Potency | 15.8419 | 2 | 12 |
| Chain A, 2-oxoglutarate Oxygenase | Homo sapiens (human) | Potency | 16.8184 | 1 | 4 |
| Chain A, ATP-DEPENDENT DNA HELICASE Q1 | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
| Chain A, Beta-lactamase | Escherichia coli K-12 | Potency | 180.0524 | 2 | 4 |
| Chain A, Cruzipain | Trypanosoma cruzi | Potency | 39.8107 | 1 | 1 |
| Chain A, Ferritin light chain | Equus caballus (horse) | Potency | 20.9776 | 3 | 3 |
| Chain A, HADH2 protein | Homo sapiens (human) | Potency | 0.1995 | 1 | 1 |
| Chain A, JmjC domain-containing histone demethylation protein 3A | Homo sapiens (human) | Potency | 49.0460 | 1 | 4 |
| Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE | Homo sapiens (human) | Potency | 6.8171 | 1 | 7 |
| Chain A, Putative fructose-1,6-bisphosphate aldolase | Giardia intestinalis | Potency | 15.8114 | 1 | 1 |
| Chain A, TYROSYL-DNA PHOSPHODIESTERASE | Homo sapiens (human) | Potency | 23.7897 | 1 | 6 |
| Chain B, HADH2 protein | Homo sapiens (human) | Potency | 0.1995 | 1 | 1 |
| chaperonin-containing TCP-1 beta subunit homolog | Homo sapiens (human) | Potency | 15.8489 | 1 | 1 |
| chromobox protein homolog 1 | Homo sapiens (human) | Potency | 45.3578 | 2 | 14 |
| cytochrome P450 2C19 precursor | Homo sapiens (human) | Potency | 8.1818 | 1 | 9 |
| cytochrome P450 2C9 precursor | Homo sapiens (human) | Potency | 20.8114 | 1 | 2 |
| cytochrome P450 2C9, partial | Homo sapiens (human) | Potency | 17.7677 | 1 | 10 |
| cytochrome P450 2D6 | Homo sapiens (human) | Potency | 7.4136 | 1 | 16 |
| cytochrome P450 2D6 isoform 1 | Homo sapiens (human) | Potency | 4.6208 | 1 | 26 |
| cytochrome P450 3A4 isoform 1 | Homo sapiens (human) | Potency | 10.5572 | 2 | 28 |
| cytochrome P450 family 3 subfamily A polypeptide 4 | Homo sapiens (human) | Potency | 11.0975 | 2 | 15 |
| cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a | Homo sapiens (human) | Potency | 36.5031 | 1 | 7 |
| D(1A) dopamine receptor | Homo sapiens (human) | Potency | 5.2081 | 3 | 27 |
| D(1A) dopamine receptor | Sus scrofa (pig) | Potency | 19.2108 | 1 | 7 |
| Disintegrin and metalloproteinase domain-containing protein 17 | Homo sapiens (human) | Potency | 13.7828 | 1 | 4 |
| DNA dC->dU-editing enzyme APOBEC-3G isoform 1 | Homo sapiens (human) | Potency | 22.3872 | 1 | 1 |
| DNA polymerase beta | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| DNA polymerase iota isoform a (long) | Homo sapiens (human) | Potency | 45.4144 | 1 | 6 |
| DNA polymerase kappa isoform 1 | Homo sapiens (human) | Potency | 31.4197 | 1 | 3 |
| dopamine D1 receptor | Homo sapiens (human) | Potency | 0.0580 | 1 | 1 |
| endonuclease IV | Escherichia coli | Potency | 19.4022 | 1 | 3 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 31.0911 | 10 | 65 |
| estrogen receptor 2 (ER beta) | Homo sapiens (human) | Potency | 32.6179 | 2 | 13 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 34.5795 | 9 | 66 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 16.0998 | 2 | 37 |
| EWS/FLI fusion protein | Homo sapiens (human) | Potency | 22.2485 | 4 | 14 |
| eyes absent homolog 2 isoform a | Homo sapiens (human) | Potency | 22.3872 | 1 | 1 |
| farnesoid X nuclear receptor | Homo sapiens (human) | Potency | 37.1550 | 2 | 7 |
| flap endonuclease 1 | Homo sapiens (human) | Potency | 18.6437 | 1 | 5 |
| Fumarate hydratase | Homo sapiens (human) | Potency | 28.5849 | 1 | 10 |
| G | Vesicular stomatitis virus | Potency | 17.7677 | 1 | 10 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | Potency | 10.4150 | 1 | 15 |
| GALC protein | Homo sapiens (human) | Potency | 0.6566 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Potency | 10.4150 | 1 | 15 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Potency | 10.4150 | 1 | 15 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Potency | 10.4150 | 1 | 15 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Potency | 10.4150 | 1 | 15 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | Potency | 10.4150 | 1 | 15 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | Potency | 10.4150 | 1 | 15 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | Potency | 10.4150 | 1 | 15 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Potency | 10.4150 | 1 | 15 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | Potency | 10.4150 | 1 | 15 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | Potency | 10.4150 | 1 | 15 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | Potency | 10.4150 | 1 | 15 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | Potency | 10.4150 | 1 | 15 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | Potency | 10.4150 | 1 | 15 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | Potency | 10.4150 | 1 | 15 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | Potency | 10.4150 | 1 | 15 |
| geminin | Homo sapiens (human) | Potency | 16.0657 | 4 | 27 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 14.3338 | 2 | 29 |
| glp-1 receptor, partial | Homo sapiens (human) | Potency | 16.0808 | 1 | 6 |
| GLS protein | Homo sapiens (human) | Potency | 14.1117 | 2 | 10 |
| glucocerebrosidase | Homo sapiens (human) | Potency | 21.0199 | 1 | 7 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 21.4572 | 3 | 24 |
| Glutamate receptor 2 | Rattus norvegicus (Norway rat) | Potency | 48.6997 | 1 | 6 |
| Glycoprotein hormones alpha chain | Homo sapiens (human) | Potency | 14.1254 | 1 | 2 |
| GTP-binding nuclear protein Ran isoform 1 | Homo sapiens (human) | Potency | 2.1967 | 1 | 2 |
| Guanine nucleotide-binding protein G | Homo sapiens (human) | Potency | 25.1189 | 1 | 1 |
| heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | Homo sapiens (human) | Potency | 55.2992 | 1 | 2 |
| heat shock protein beta-1 | Homo sapiens (human) | Potency | 32.2426 | 2 | 5 |
| Histamine H2 receptor | Cavia porcellus (domestic guinea pig) | Potency | 13.2884 | 2 | 36 |
| histone acetyltransferase KAT2A isoform 1 | Homo sapiens (human) | Potency | 32.7379 | 1 | 4 |
| histone deacetylase 9 isoform 3 | Homo sapiens (human) | Potency | 21.1317 | 1 | 1 |
| Histone H2A.x | Cricetulus griseus (Chinese hamster) | Potency | 73.6544 | 2 | 9 |
| histone-lysine N-methyltransferase 2A isoform 2 precursor | Homo sapiens (human) | Potency | 70.7946 | 1 | 1 |
| HLA class I histocompatibility antigen, B alpha chain | Homo sapiens (human) | Potency | 17.7677 | 1 | 10 |
| huntingtin isoform 2 | Homo sapiens (human) | Potency | 31.8326 | 1 | 2 |
| hypoxia-inducible factor 1 alpha subunit | Homo sapiens (human) | Potency | 15.7774 | 1 | 4 |
| hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | Homo sapiens (human) | Potency | 12.4545 | 2 | 18 |
| IDH1 | Homo sapiens (human) | Potency | 20.4047 | 1 | 6 |
| importin subunit beta-1 isoform 1 | Homo sapiens (human) | Potency | 2.1967 | 1 | 2 |
| Inositol hexakisphosphate kinase 1 | Homo sapiens (human) | Potency | 17.7677 | 1 | 20 |
| Inositol monophosphatase 1 | Rattus norvegicus (Norway rat) | Potency | 5.2246 | 1 | 9 |
| Integrin alpha-IIb | Homo sapiens (human) | Potency | 20.6452 | 1 | 5 |
| Integrin beta-3 | Homo sapiens (human) | Potency | 20.6452 | 1 | 5 |
| Interferon beta | Homo sapiens (human) | Potency | 15.8368 | 3 | 19 |
| lamin isoform A-delta10 | Homo sapiens (human) | Potency | 9.9594 | 2 | 22 |
| lethal factor (plasmid) | Bacillus anthracis str. A2012 | Potency | 17.6678 | 1 | 13 |
| Luciferase | Photinus pyralis (common eastern firefly) | Potency | 14.3818 | 1 | 1 |
| lysosomal alpha-glucosidase preproprotein | Homo sapiens (human) | Potency | 9.3546 | 3 | 3 |
| M-phase phosphoprotein 8 | Homo sapiens (human) | Potency | 26.7319 | 1 | 9 |
| Microtubule-associated protein tau | Homo sapiens (human) | Potency | 22.2024 | 2 | 10 |
| mitogen-activated protein kinase 1 | Homo sapiens (human) | Potency | 19.1311 | 2 | 20 |
| muscarinic acetylcholine receptor M1 | Rattus norvegicus (Norway rat) | Potency | 6.5253 | 2 | 22 |
| muscleblind-like protein 1 isoform 1 | Homo sapiens (human) | Potency | 100.0000 | 1 | 1 |
| Neuronal acetylcholine receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Potency | 11.2202 | 1 | 1 |
| Neuronal acetylcholine receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Potency | 11.2202 | 1 | 1 |
| neuropeptide S receptor isoform A | Homo sapiens (human) | Potency | 22.6788 | 3 | 6 |
| NFKB1 protein, partial | Homo sapiens (human) | Potency | 13.4658 | 2 | 12 |
| nonstructural protein 1 | Influenza A virus (A/WSN/1933(H1N1)) | Potency | 4.4382 | 1 | 3 |
| NPC intracellular cholesterol transporter 1 precursor | Homo sapiens (human) | Potency | 58.0479 | 1 | 3 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 30.8190 | 3 | 15 |
| nuclear factor erythroid 2-related factor 2 isoform 2 | Homo sapiens (human) | Potency | 0.0292 | 2 | 2 |
| nuclear factor NF-kappa-B p105 subunit isoform 1 | Homo sapiens (human) | Potency | 25.1189 | 1 | 1 |
| nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a | Homo sapiens (human) | Potency | 27.8547 | 1 | 3 |
| nuclear receptor ROR-gamma isoform 1 | Mus musculus (house mouse) | Potency | 21.3050 | 2 | 7 |
| nuclear receptor subfamily 1, group I, member 2 | Rattus norvegicus (Norway rat) | Potency | 1.5849 | 1 | 1 |
| nuclear receptor subfamily 1, group I, member 3 | Homo sapiens (human) | Potency | 36.9666 | 3 | 26 |
| parathyroid hormone/parathyroid hormone-related peptide receptor precursor | Homo sapiens (human) | Potency | 44.6684 | 1 | 1 |
| Parkin | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| peripheral myelin protein 22 | Rattus norvegicus (Norway rat) | Potency | 23.6071 | 1 | 7 |
| peripheral myelin protein 22 isoform 1 | Homo sapiens (human) | Potency | 69.0346 | 1 | 5 |
| peroxisome proliferator activated receptor gamma | Homo sapiens (human) | Potency | 23.7653 | 5 | 10 |
| peroxisome proliferator-activated receptor delta | Homo sapiens (human) | Potency | 35.9772 | 5 | 16 |
| phosphopantetheinyl transferase | Bacillus subtilis | Potency | 55.1861 | 1 | 8 |
| PINK1 | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| plasminogen precursor | Mus musculus (house mouse) | Potency | 12.5893 | 1 | 1 |
| polyprotein | Zika virus | Potency | 28.5849 | 1 | 10 |
| Polyunsaturated fatty acid lipoxygenase ALOX15B | Homo sapiens (human) | Potency | 11.7838 | 1 | 15 |
| potassium voltage-gated channel subfamily H member 2 isoform d | Homo sapiens (human) | Potency | 9.5919 | 1 | 18 |
| PPM1D protein | Homo sapiens (human) | Potency | 13.1103 | 1 | 4 |
| pregnane X nuclear receptor | Homo sapiens (human) | Potency | 24.7340 | 3 | 16 |
| progesterone receptor | Homo sapiens (human) | Potency | 26.7884 | 3 | 21 |
| Rap guanine nucleotide exchange factor 4 | Homo sapiens (human) | Potency | 24.0353 | 1 | 2 |
| RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 29.1608 | 2 | 18 |
| ras-related protein Rab-9A | Homo sapiens (human) | Potency | 84.7366 | 1 | 4 |
| regulator of G-protein signaling 4 | Homo sapiens (human) | Potency | 12.8572 | 1 | 11 |
| retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 34.3312 | 3 | 24 |
| retinoid X nuclear receptor alpha | Homo sapiens (human) | Potency | 26.0978 | 3 | 18 |
| serine/threonine-protein kinase mTOR isoform 1 | Homo sapiens (human) | Potency | 18.9068 | 4 | 21 |
| SMAD family member 2 | Homo sapiens (human) | Potency | 27.7414 | 1 | 2 |
| SMAD family member 3 | Homo sapiens (human) | Potency | 27.7414 | 1 | 2 |
| Smad3 | Homo sapiens (human) | Potency | 31.8654 | 1 | 5 |
| snurportin-1 | Homo sapiens (human) | Potency | 2.1967 | 1 | 2 |
| Spike glycoprotein | Severe acute respiratory syndrome-related coronavirus | Potency | 22.8120 | 2 | 15 |
| survival motor neuron protein isoform d | Homo sapiens (human) | Potency | 7.0527 | 1 | 7 |
| TAR DNA-binding protein 43 | Homo sapiens (human) | Potency | 5.6807 | 1 | 3 |
| TDP1 protein | Homo sapiens (human) | Potency | 20.7748 | 2 | 62 |
| thioredoxin glutathione reductase | Schistosoma mansoni | Potency | 3.9811 | 1 | 1 |
| thioredoxin reductase | Rattus norvegicus (Norway rat) | Potency | 16.8089 | 3 | 14 |
| Thrombopoietin | Homo sapiens (human) | Potency | 13.0271 | 2 | 16 |
| thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 30.3424 | 3 | 43 |
| thyroid hormone receptor beta isoform a | Homo sapiens (human) | Potency | 3.5481 | 1 | 1 |
| thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 26.4687 | 6 | 24 |
| thyrotropin-releasing hormone receptor | Homo sapiens (human) | Potency | 17.3768 | 1 | 1 |
| transcriptional regulator ERG isoform 3 | Homo sapiens (human) | Potency | 15.0654 | 1 | 2 |
| transient receptor potential cation channel subfamily V member 1 | Homo sapiens (human) | Potency | 15.6739 | 1 | 3 |
| ubiquitin carboxyl-terminal hydrolase 2 isoform a | Homo sapiens (human) | Potency | 13.7828 | 1 | 4 |
| urokinase plasminogen activator surface receptor precursor | Mus musculus (house mouse) | Potency | 12.5893 | 1 | 1 |
| urokinase-type plasminogen activator precursor | Mus musculus (house mouse) | Potency | 12.5893 | 1 | 1 |
| USP1 protein, partial | Homo sapiens (human) | Potency | 44.9738 | 3 | 17 |
| v-jun sarcoma virus 17 oncogene homolog (avian) | Homo sapiens (human) | Potency | 21.9774 | 2 | 28 |
| vitamin D (1,25- dihydroxyvitamin D3) receptor | Homo sapiens (human) | Potency | 38.2745 | 4 | 12 |
| vitamin D3 receptor isoform VDRA | Homo sapiens (human) | Potency | 75.8996 | 1 | 6 |
| Voltage-dependent calcium channel gamma-2 subunit | Mus musculus (house mouse) | Potency | 48.6997 | 1 | 6 |
| Vpr | Human immunodeficiency virus 1 | Potency | 12.5893 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase | Homo sapiens (human) | Ki | 0.0990 | 1 | 2 |
| 3-hydroxy-3-methylglutaryl-coenzyme A reductase | Rattus norvegicus (Norway rat) | Ki | 0.0140 | 1 | 1 |
| 5-hydroxytryptamine receptor 1A | Homo sapiens (human) | IC50 | 1.5000 | 1 | 1 |
| 5-hydroxytryptamine receptor 1A | Rattus norvegicus (Norway rat) | IC50 | 3.2112 | 7 | 13 |
| 5-hydroxytryptamine receptor 1A | Homo sapiens (human) | Ki | 2.6071 | 10 | 13 |
| 5-hydroxytryptamine receptor 1A | Rattus norvegicus (Norway rat) | Ki | 1.5243 | 9 | 14 |
| 5-hydroxytryptamine receptor 1B | Rattus norvegicus (Norway rat) | IC50 | 2.6162 | 4 | 9 |
| 5-hydroxytryptamine receptor 1B | Rattus norvegicus (Norway rat) | Ki | 1.4027 | 1 | 6 |
| 5-hydroxytryptamine receptor 1D | Rattus norvegicus (Norway rat) | IC50 | 2.9393 | 3 | 3 |
| 5-hydroxytryptamine receptor 1F | Rattus norvegicus (Norway rat) | IC50 | 2.9393 | 3 | 3 |
| 5-hydroxytryptamine receptor 2A | Homo sapiens (human) | IC50 | 0.4881 | 4 | 18 |
| 5-hydroxytryptamine receptor 2A | Rattus norvegicus (Norway rat) | IC50 | 1.2262 | 11 | 12 |
| 5-hydroxytryptamine receptor 2A | Homo sapiens (human) | Ki | 0.0848 | 29 | 53 |
| 5-hydroxytryptamine receptor 2A | Mus musculus (house mouse) | Ki | 0.0265 | 1 | 1 |
| 5-hydroxytryptamine receptor 2A | Rattus norvegicus (Norway rat) | Ki | 0.9350 | 23 | 30 |
| 5-hydroxytryptamine receptor 2A | Sus scrofa (pig) | Ki | 0.0300 | 1 | 1 |
| 5-hydroxytryptamine receptor 2B | Homo sapiens (human) | IC50 | 1.0816 | 1 | 14 |
| 5-hydroxytryptamine receptor 2B | Rattus norvegicus (Norway rat) | IC50 | 1.6083 | 8 | 9 |
| 5-hydroxytryptamine receptor 2B | Homo sapiens (human) | Ki | 0.5419 | 5 | 18 |
| 5-hydroxytryptamine receptor 2B | Mus musculus (house mouse) | Ki | 0.0265 | 1 | 1 |
| 5-hydroxytryptamine receptor 2B | Rattus norvegicus (Norway rat) | Ki | 1.9468 | 10 | 14 |
| 5-hydroxytryptamine receptor 2C | Homo sapiens (human) | IC50 | 2.4066 | 2 | 13 |
| 5-hydroxytryptamine receptor 2C | Rattus norvegicus (Norway rat) | IC50 | 1.5475 | 9 | 10 |
| 5-hydroxytryptamine receptor 2C | Homo sapiens (human) | Ki | 1.8145 | 19 | 34 |
| 5-hydroxytryptamine receptor 2C | Rattus norvegicus (Norway rat) | Ki | 2.1303 | 11 | 15 |
| 5-hydroxytryptamine receptor 2C | Mus musculus (house mouse) | Ki | 0.0265 | 1 | 1 |
| 5-hydroxytryptamine receptor 3A | Homo sapiens (human) | IC50 | 0.0030 | 10 | 10 |
| 5-hydroxytryptamine receptor 3A | Rattus norvegicus (Norway rat) | IC50 | 0.6200 | 2 | 3 |
| 5-hydroxytryptamine receptor 3A | Homo sapiens (human) | Ki | 0.0402 | 5 | 5 |
| 5-hydroxytryptamine receptor 3A | Mus musculus (house mouse) | Ki | 3.4667 | 2 | 3 |
| 5-hydroxytryptamine receptor 3A | Rattus norvegicus (Norway rat) | Ki | 0.4224 | 7 | 8 |
| 5-hydroxytryptamine receptor 3B | Homo sapiens (human) | IC50 | 0.0009 | 1 | 1 |
| 5-hydroxytryptamine receptor 3B | Rattus norvegicus (Norway rat) | IC50 | 0.6200 | 2 | 3 |
| 5-hydroxytryptamine receptor 3B | Homo sapiens (human) | Ki | 0.1995 | 1 | 1 |
| 5-hydroxytryptamine receptor 3B | Mus musculus (house mouse) | Ki | 0.2000 | 1 | 2 |
| 5-hydroxytryptamine receptor 3B | Rattus norvegicus (Norway rat) | Ki | 0.4224 | 7 | 8 |
| 5-hydroxytryptamine receptor 3C | Homo sapiens (human) | Ki | 0.1995 | 1 | 1 |
| 5-hydroxytryptamine receptor 3D | Homo sapiens (human) | Ki | 0.1995 | 1 | 1 |
| 5-hydroxytryptamine receptor 3E | Homo sapiens (human) | Ki | 0.1995 | 1 | 1 |
| 5-hydroxytryptamine receptor 4 | Cavia porcellus (domestic guinea pig) | IC50 | 1.5332 | 2 | 14 |
| 5-hydroxytryptamine receptor 4 | Cavia porcellus (domestic guinea pig) | Ki | 1.0509 | 2 | 13 |
| 5-hydroxytryptamine receptor 4 | Homo sapiens (human) | Ki | 0.0006 | 1 | 1 |
| 5-hydroxytryptamine receptor 4 | Rattus norvegicus (Norway rat) | Ki | 0.0800 | 1 | 1 |
| 5-hydroxytryptamine receptor 6 | Homo sapiens (human) | IC50 | 0.6080 | 1 | 5 |
| 5-hydroxytryptamine receptor 6 | Homo sapiens (human) | Ki | 0.4631 | 19 | 30 |
| 5-hydroxytryptamine receptor 7 | Cavia porcellus (domestic guinea pig) | IC50 | 60.9333 | 1 | 12 |
| 5-hydroxytryptamine receptor 7 | Homo sapiens (human) | Ki | 0.4473 | 11 | 17 |
| 5-hydroxytryptamine receptor 7 | Rattus norvegicus (Norway rat) | Ki | 0.0953 | 2 | 3 |
| 6-phosphogluconate dehydrogenase, decarboxylating | Homo sapiens (human) | Ki | 2,111.3000 | 1 | 1 |
| Acetylcholinesterase | Homo sapiens (human) | IC50 | 20.0000 | 1 | 1 |
| Adenosine receptor A1 | Rattus norvegicus (Norway rat) | Ki | 0.2015 | 1 | 2 |
| Adenylate cyclase type 1 | Rattus norvegicus (Norway rat) | IC50 | 1.8000 | 2 | 2 |
| Adenylate cyclase type 1 | Rattus norvegicus (Norway rat) | Ki | 0.1180 | 1 | 1 |
| Adenylate cyclase type 2 | Rattus norvegicus (Norway rat) | IC50 | 1.8000 | 2 | 2 |
| Adenylate cyclase type 2 | Rattus norvegicus (Norway rat) | Ki | 0.1180 | 1 | 1 |
| Adenylate cyclase type 3 | Rattus norvegicus (Norway rat) | IC50 | 1.8000 | 2 | 2 |
| Adenylate cyclase type 3 | Rattus norvegicus (Norway rat) | Ki | 0.1180 | 1 | 1 |
| Adenylate cyclase type 4 | Rattus norvegicus (Norway rat) | IC50 | 1.8000 | 2 | 2 |
| Adenylate cyclase type 4 | Rattus norvegicus (Norway rat) | Ki | 0.1180 | 1 | 1 |
| Adenylate cyclase type 5 | Rattus norvegicus (Norway rat) | IC50 | 1.3833 | 3 | 3 |
| Adenylate cyclase type 5 | Rattus norvegicus (Norway rat) | Ki | 0.1180 | 1 | 1 |
| Adenylate cyclase type 6 | Rattus norvegicus (Norway rat) | IC50 | 1.8000 | 2 | 2 |
| Adenylate cyclase type 6 | Rattus norvegicus (Norway rat) | Ki | 0.1180 | 1 | 1 |
| Adenylate cyclase type 8 | Rattus norvegicus (Norway rat) | IC50 | 1.8000 | 2 | 2 |
| Adenylate cyclase type 8 | Rattus norvegicus (Norway rat) | Ki | 0.1180 | 1 | 1 |
| Adenylyl cyclase 7 | Rattus norvegicus (Norway rat) | IC50 | 1.8000 | 2 | 2 |
| Adenylyl cyclase 7 | Rattus norvegicus (Norway rat) | Ki | 0.1180 | 1 | 1 |
| Aldehyde oxidase | Homo sapiens (human) | IC50 | 0.3015 | 1 | 2 |
| Aldehyde oxidase | Homo sapiens (human) | Ki | 2.3000 | 1 | 1 |
| Aldehyde oxidase 1 | Macaca fascicularis (crab-eating macaque) | IC50 | 3.6000 | 1 | 1 |
| Aldehyde oxidase 1 | Mus musculus (house mouse) | IC50 | 6.1000 | 1 | 1 |
| Aldehyde oxidase 1 | Oryctolagus cuniculus (rabbit) | IC50 | 20.0000 | 1 | 1 |
| Aldehyde oxidase 1 | Rattus norvegicus (Norway rat) | IC50 | 0.7400 | 1 | 1 |
| Aldo-keto reductase family 1 member B1 | Rattus norvegicus (Norway rat) | IC50 | 2.7652 | 1 | 9 |
| Aldo-keto reductase family 1 member B1 | Rattus norvegicus (Norway rat) | Ki | 2.7423 | 1 | 9 |
| Alpha-1A adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 4.1438 | 7 | 10 |
| Alpha-1A adrenergic receptor | Homo sapiens (human) | Ki | 0.0249 | 6 | 8 |
| Alpha-1A adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 1.3170 | 12 | 17 |
| Alpha-1B adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 4.1438 | 7 | 10 |
| Alpha-1B adrenergic receptor | Homo sapiens (human) | Ki | 0.0208 | 5 | 6 |
| Alpha-1B adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 1.2476 | 13 | 18 |
| Alpha-1D adrenergic receptor | Homo sapiens (human) | IC50 | 0.3940 | 1 | 10 |
| Alpha-1D adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 4.1438 | 7 | 10 |
| Alpha-1D adrenergic receptor | Homo sapiens (human) | Ki | 0.1288 | 6 | 16 |
| Alpha-1D adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 1.3170 | 12 | 17 |
| Alpha-2A adrenergic receptor | Homo sapiens (human) | IC50 | 1.6244 | 1 | 12 |
| Alpha-2A adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 4.5896 | 2 | 2 |
| Alpha-2A adrenergic receptor | Homo sapiens (human) | Ki | 0.8045 | 4 | 16 |
| Alpha-2A adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 3.2453 | 2 | 3 |
| Alpha-2B adrenergic receptor | Homo sapiens (human) | IC50 | 0.7188 | 1 | 9 |
| Alpha-2B adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 4.5896 | 2 | 2 |
| Alpha-2B adrenergic receptor | Homo sapiens (human) | Ki | 0.6936 | 3 | 12 |
| Alpha-2B adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 3.2453 | 2 | 3 |
| Alpha-2C adrenergic receptor | Homo sapiens (human) | IC50 | 0.9936 | 1 | 9 |
| Alpha-2C adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 4.5896 | 2 | 2 |
| Alpha-2C adrenergic receptor | Homo sapiens (human) | Ki | 0.5193 | 4 | 13 |
| Alpha-2C adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 3.2453 | 2 | 3 |
| Androgen receptor | Homo sapiens (human) | IC50 | 152.1780 | 1 | 2 |
| Androgen receptor | Rattus norvegicus (Norway rat) | IC50 | 26.6800 | 1 | 1 |
| Androgen receptor | Rattus norvegicus (Norway rat) | Ki | 17.7860 | 1 | 1 |
| Angiotensin-converting enzyme | Oryctolagus cuniculus (rabbit) | IC50 | 19.7380 | 2 | 8 |
| Angiotensin-converting enzyme | Oryctolagus cuniculus (rabbit) | Ki | 6.9507 | 1 | 6 |
| Angiotensin-converting enzyme 2 | Homo sapiens (human) | IC50 | 12.4425 | 1 | 4 |
| AP-2 complex subunit sigma | Rattus norvegicus (Norway rat) | Ki | 0.0242 | 1 | 1 |
| ATP-binding cassette sub-family C member 3 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 12 |
| ATP-dependent translocase ABCB1 | Homo sapiens (human) | IC50 | 7.4250 | 4 | 4 |
| ATP-dependent translocase ABCB1 | Homo sapiens (human) | Ki | 7.0400 | 2 | 5 |
| bcl-2-related protein A1 | Mus musculus (house mouse) | IC50 | 20.0000 | 1 | 1 |
| Beta-1 adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 1 | 1 |
| Beta-2 adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 2.3000 | 1 | 1 |
| Beta-2 adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 1 | 1 |
| Beta-3 adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 1 | 1 |
| Beta-carbonic anhydrase 1 | Mycobacterium tuberculosis H37Rv | Ki | 2.3000 | 1 | 1 |
| Beta-glucuronidase | Rattus norvegicus (Norway rat) | IC50 | 7.8000 | 1 | 1 |
| Bile salt export pump | Homo sapiens (human) | IC50 | 145.3454 | 7 | 37 |
| Bile salt export pump | Rattus norvegicus (Norway rat) | IC50 | 561.1500 | 1 | 2 |
| Broad substrate specificity ATP-binding cassette transporter ABCG2 | Homo sapiens (human) | IC50 | 17.2000 | 1 | 1 |
| C-8 sterol isomerase | Saccharomyces cerevisiae S288C | Ki | 0.2502 | 1 | 2 |
| Calcitonin gene-related peptide type 1 receptor | Homo sapiens (human) | Ki | 0.0004 | 1 | 1 |
| Calcium release-activated calcium channel protein 1 | Homo sapiens (human) | IC50 | 500.0000 | 2 | 2 |
| Calcium-dependent protein kinase 4 | Plasmodium falciparum 3D7 | Ki | 150.0000 | 1 | 1 |
| Calmodulin | Bos taurus (cattle) | IC50 | 2.5000 | 1 | 2 |
| Calmodulin-1 | Homo sapiens (human) | IC50 | 21.3900 | 3 | 4 |
| Calmodulin-1 | Homo sapiens (human) | Ki | 19.2800 | 1 | 1 |
| Canalicular multispecific organic anion transporter 1 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 12 |
| Carbonic anhydrase | Candida albicans SC5314 | Ki | 0.7600 | 2 | 2 |
| Carbonic anhydrase | Helicobacter pylori 26695 | Ki | 0.1915 | 2 | 2 |
| Carbonic anhydrase | Saccharomyces cerevisiae S288C | Ki | 0.1240 | 1 | 1 |
| Carbonic anhydrase | Stylophora pistillata | Ki | 0.4150 | 1 | 1 |
| Carbonic anhydrase | Anopheles gambiae (African malaria mosquito) | Ki | 0.0295 | 1 | 1 |
| Carbonic anhydrase | Astrosclera willeyana | Ki | 0.3780 | 1 | 1 |
| Carbonic anhydrase | Cryptococcus neoformans var. grubii | Ki | 0.8120 | 1 | 1 |
| Carbonic anhydrase | Nakaseomyces glabratus CBS 138 | Ki | 0.1130 | 1 | 1 |
| Carbonic anhydrase | Stylophora pistillata | Ki | 0.4300 | 2 | 2 |
| Carbonic anhydrase | Sulfurihydrogenibium sp. YO3AOP1 | Ki | 0.0674 | 1 | 1 |
| Carbonic anhydrase 1 | Homo sapiens (human) | IC50 | 1.2000 | 1 | 1 |
| Carbonic anhydrase 1 | Homo sapiens (human) | Ki | 6.8484 | 34 | 36 |
| Carbonic anhydrase 12 | Homo sapiens (human) | Ki | 0.0039 | 3 | 3 |
| Carbonic anhydrase 15 | Mus musculus (house mouse) | Ki | 0.0730 | 1 | 1 |
| Carbonic anhydrase 2 | Homo sapiens (human) | IC50 | 0.0400 | 1 | 1 |
| Carbonic anhydrase 2 | Homo sapiens (human) | Ki | 0.7530 | 41 | 44 |
| Carbonic anhydrase 2 | Mycobacterium tuberculosis H37Rv | Ki | 0.2660 | 1 | 1 |
| Carbonic anhydrase 3 | Homo sapiens (human) | Ki | 10.6000 | 1 | 1 |
| Carbonic anhydrase 4 | Bos taurus (cattle) | IC50 | 0.6200 | 1 | 1 |
| Carbonic anhydrase 5A, mitochondrial | Homo sapiens (human) | Ki | 0.1740 | 1 | 1 |
| Carbonic anhydrase 5B, mitochondrial | Homo sapiens (human) | Ki | 0.0180 | 1 | 1 |
| Carbonic anhydrase 6 | Homo sapiens (human) | Ki | 2.0072 | 4 | 6 |
| Carbonic anhydrase 7 | Homo sapiens (human) | Ki | 2.4212 | 3 | 3 |
| Carbonic anhydrase 9 | Homo sapiens (human) | Ki | 0.0409 | 6 | 7 |
| Carbonic anhydrase, alpha family | Hydrogenovibrio crunogenus XCL-2 | Ki | 0.8730 | 1 | 1 |
| Chloroquine resistance transporter | Plasmodium falciparum (malaria parasite P. falciparum) | IC50 | 85.0000 | 1 | 1 |
| Cholecystokinin receptor type A | Cavia porcellus (domestic guinea pig) | Ki | 0.0500 | 1 | 1 |
| Cholinesterase | Equus caballus (horse) | IC50 | 7.4000 | 1 | 1 |
| Cocaine esterase | Homo sapiens (human) | Ki | 0.0063 | 1 | 1 |
| Cruzipain | Trypanosoma cruzi | IC50 | 212.0000 | 2 | 2 |
| Cys-loop ligand-gated ion channel | Dickeya chrysanthemi | IC50 | 158.0000 | 1 | 1 |
| Cytochrome P450 1A2 | Homo sapiens (human) | IC50 | 4.2016 | 2 | 3 |
| Cytochrome P450 2B6 | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| Cytochrome P450 2C19 | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| Cytochrome P450 2C9 | Homo sapiens (human) | IC50 | 24.9483 | 2 | 6 |
| Cytochrome P450 2D6 | Homo sapiens (human) | IC50 | 2.9906 | 2 | 6 |
| Cytochrome P450 2D6 | Homo sapiens (human) | Ki | 3.9800 | 2 | 2 |
| Cytochrome P450 2J2 | Homo sapiens (human) | IC50 | 27.9380 | 1 | 5 |
| Cytochrome P450 3A4 | Homo sapiens (human) | IC50 | 0.3802 | 5 | 5 |
| Cytochrome P450 3A4 | Homo sapiens (human) | Ki | 0.0060 | 1 | 2 |
| D | Bos taurus (cattle) | IC50 | 0.4594 | 4 | 7 |
| D | Rattus norvegicus (Norway rat) | IC50 | 0.2021 | 16 | 25 |
| D | Bos taurus (cattle) | Ki | 50.0000 | 2 | 2 |
| D | Rattus norvegicus (Norway rat) | Ki | 0.1691 | 21 | 37 |
| D(1A) dopamine receptor | Homo sapiens (human) | IC50 | 0.8584 | 2 | 8 |
| D(1A) dopamine receptor | Homo sapiens (human) | Ki | 0.2246 | 12 | 21 |
| D(1A) dopamine receptor | Sus scrofa (pig) | Ki | 0.0095 | 1 | 1 |
| D(1B) dopamine receptor | Homo sapiens (human) | IC50 | 0.0050 | 1 | 1 |
| D(1B) dopamine receptor | Rattus norvegicus (Norway rat) | IC50 | 0.1375 | 11 | 19 |
| D(1B) dopamine receptor | Homo sapiens (human) | Ki | 0.1152 | 5 | 5 |
| D(1B) dopamine receptor | Rattus norvegicus (Norway rat) | Ki | 0.3459 | 3 | 6 |
| D(2) dopamine receptor | Bos taurus (cattle) | IC50 | 0.3327 | 6 | 10 |
| D(2) dopamine receptor | Canis lupus familiaris (dog) | IC50 | 0.2000 | 1 | 1 |
| D(2) dopamine receptor | Homo sapiens (human) | IC50 | 0.2236 | 18 | 32 |
| D(2) dopamine receptor | Rattus norvegicus (Norway rat) | IC50 | 0.1247 | 35 | 57 |
| D(2) dopamine receptor | Bos taurus (cattle) | Ki | 0.0253 | 4 | 4 |
| D(2) dopamine receptor | Chlorocebus aethiops (grivet) | Ki | 0.0049 | 2 | 2 |
| D(2) dopamine receptor | Homo sapiens (human) | Ki | 0.0684 | 116 | 148 |
| D(2) dopamine receptor | Rattus norvegicus (Norway rat) | Ki | 0.0378 | 48 | 94 |
| D(3) dopamine receptor | Homo sapiens (human) | IC50 | 0.3619 | 8 | 21 |
| D(3) dopamine receptor | Rattus norvegicus (Norway rat) | IC50 | 0.1375 | 11 | 19 |
| D(3) dopamine receptor | Chlorocebus aethiops (grivet) | Ki | 0.0030 | 1 | 1 |
| D(3) dopamine receptor | Homo sapiens (human) | Ki | 0.0416 | 57 | 87 |
| D(3) dopamine receptor | Rattus norvegicus (Norway rat) | Ki | 0.1508 | 11 | 15 |
| D(4) dopamine receptor | Homo sapiens (human) | IC50 | 0.4929 | 6 | 9 |
| D(4) dopamine receptor | Rattus norvegicus (Norway rat) | IC50 | 0.1375 | 11 | 19 |
| D(4) dopamine receptor | Homo sapiens (human) | Ki | 0.1504 | 46 | 56 |
| D(4) dopamine receptor | Rattus norvegicus (Norway rat) | Ki | 0.3049 | 3 | 7 |
| Delta carbonic anhydrase | Conticribra weissflogii | Ki | 0.2590 | 1 | 1 |
| Delta-type opioid receptor | Homo sapiens (human) | IC50 | 20.8940 | 1 | 1 |
| Delta-type opioid receptor | Homo sapiens (human) | Ki | 7.3650 | 1 | 1 |
| Delta-type opioid receptor | Mus musculus (house mouse) | Ki | 0.6200 | 2 | 2 |
| Delta-type opioid receptor | Rattus norvegicus (Norway rat) | Ki | 5.3125 | 3 | 4 |
| DNA-dependent protein kinase catalytic subunit | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Emopamil-binding protein-like | Homo sapiens (human) | Ki | 0.0039 | 1 | 1 |
| Epidermal growth factor receptor | Homo sapiens (human) | IC50 | 28.8680 | 1 | 1 |
| Estrogen receptor 1 | Homo sapiens (human) | IC50 | 50.0000 | 1 | 1 |
| estrogen receptor beta isoform 1 | Homo sapiens (human) | IC50 | 50.0000 | 1 | 1 |
| Fatty-acid amide hydrolase 1 | Homo sapiens (human) | IC50 | 52.0000 | 1 | 1 |
| Fatty-acid amide hydrolase 1 | Rattus norvegicus (Norway rat) | IC50 | 14.0000 | 1 | 1 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | IC50 | 13.7857 | 4 | 7 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Homo sapiens (human) | IC50 | 28.0000 | 3 | 3 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | IC50 | 13.7857 | 4 | 7 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | IC50 | 13.7857 | 4 | 7 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | IC50 | 13.7857 | 4 | 7 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | IC50 | 13.7857 | 4 | 7 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | IC50 | 13.7857 | 4 | 7 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | IC50 | 13.7857 | 4 | 7 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | IC50 | 13.7857 | 4 | 7 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | IC50 | 13.7857 | 4 | 7 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Homo sapiens (human) | IC50 | 28.0000 | 3 | 3 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | IC50 | 13.7857 | 4 | 7 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | IC50 | 13.7857 | 4 | 7 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | IC50 | 13.7857 | 4 | 7 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | IC50 | 13.7857 | 4 | 7 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Homo sapiens (human) | IC50 | 28.0000 | 3 | 3 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | IC50 | 13.7857 | 4 | 7 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | IC50 | 13.7857 | 4 | 7 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | IC50 | 13.7857 | 4 | 7 |
| Gastrin/cholecystokinin type B receptor | Mus musculus (house mouse) | Ki | 0.0134 | 1 | 4 |
| Genome polyprotein | | IC50 | 0.7000 | 1 | 1 |
| Genome polyprotein | Human rhinovirus sp. | IC50 | 140.0000 | 1 | 1 |
| Genome polyprotein | Human rhinovirus sp. | Ki | 0.1000 | 1 | 1 |
| Glucocorticoid receptor | Homo sapiens (human) | IC50 | 0.0110 | 1 | 1 |
| Glucocorticoid receptor | Homo sapiens (human) | Ki | 0.0050 | 1 | 1 |
| Glucose-6-phosphate 1-dehydrogenase | Homo sapiens (human) | Ki | 497.2000 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 1 | Homo sapiens (human) | IC50 | 0.8500 | 2 | 2 |
| Glutamate receptor ionotropic, NMDA 1 | Rattus norvegicus (Norway rat) | IC50 | 1.3000 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 1 | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 2A | Homo sapiens (human) | IC50 | 0.8500 | 2 | 2 |
| Glutamate receptor ionotropic, NMDA 2A | Rattus norvegicus (Norway rat) | IC50 | 1.3000 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 2A | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 2B | Homo sapiens (human) | IC50 | 0.8500 | 2 | 2 |
| Glutamate receptor ionotropic, NMDA 2B | Rattus norvegicus (Norway rat) | IC50 | 1.3000 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 2B | Rattus norvegicus (Norway rat) | Ki | 5.0006 | 2 | 2 |
| Glutamate receptor ionotropic, NMDA 2C | Homo sapiens (human) | IC50 | 0.8500 | 2 | 2 |
| Glutamate receptor ionotropic, NMDA 2C | Rattus norvegicus (Norway rat) | IC50 | 1.3000 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 2C | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 2D | Homo sapiens (human) | IC50 | 0.8500 | 2 | 2 |
| Glutamate receptor ionotropic, NMDA 2D | Rattus norvegicus (Norway rat) | IC50 | 1.3000 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 2D | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 3A | Homo sapiens (human) | IC50 | 0.8500 | 2 | 2 |
| Glutamate receptor ionotropic, NMDA 3A | Rattus norvegicus (Norway rat) | IC50 | 1.3000 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 3A | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 3B | Homo sapiens (human) | IC50 | 0.8500 | 2 | 2 |
| Glutamate receptor ionotropic, NMDA 3B | Rattus norvegicus (Norway rat) | IC50 | 1.3000 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 3B | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 1 | 1 |
| Glycine receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | IC50 | 0.0110 | 1 | 1 |
| Glycine receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Ki | 0.0050 | 1 | 1 |
| Glycine receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | IC50 | 0.0110 | 1 | 1 |
| Glycine receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Ki | 0.0050 | 1 | 1 |
| Glycine receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | IC50 | 0.0110 | 1 | 1 |
| Glycine receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Ki | 0.0050 | 1 | 1 |
| Glycine receptor subunit beta | Rattus norvegicus (Norway rat) | IC50 | 0.0110 | 1 | 1 |
| Glycine receptor subunit beta | Rattus norvegicus (Norway rat) | Ki | 0.0050 | 1 | 1 |
| high affinity choline transporter 1 isoform a | Homo sapiens (human) | IC50 | 1.7625 | 2 | 2 |
| Histamine H1 receptor | Homo sapiens (human) | IC50 | 0.8185 | 3 | 14 |
| Histamine H1 receptor | Rattus norvegicus (Norway rat) | IC50 | 1.0000 | 1 | 2 |
| Histamine H1 receptor | Cavia porcellus (domestic guinea pig) | Ki | 0.0855 | 1 | 2 |
| Histamine H1 receptor | Homo sapiens (human) | Ki | 0.1363 | 11 | 23 |
| Histamine H1 receptor | Rattus norvegicus (Norway rat) | Ki | 2.1000 | 1 | 1 |
| Histamine H2 receptor | Homo sapiens (human) | IC50 | 1.9538 | 1 | 4 |
| Histamine H2 receptor | Homo sapiens (human) | Ki | 1.9212 | 1 | 4 |
| Histamine H3 receptor | Homo sapiens (human) | Ki | 1.0000 | 1 | 1 |
| Histamine H4 receptor | Homo sapiens (human) | Ki | 42.6579 | 1 | 1 |
| Integrin alpha-4 | Homo sapiens (human) | Ki | 0.0039 | 1 | 1 |
| Integrin beta-1 | Homo sapiens (human) | Ki | 0.0039 | 1 | 1 |
| Kappa-type opioid receptor | Homo sapiens (human) | IC50 | 9.0380 | 1 | 2 |
| Kappa-type opioid receptor | Cavia porcellus (domestic guinea pig) | Ki | 0.0026 | 1 | 1 |
| Kappa-type opioid receptor | Homo sapiens (human) | Ki | 3.6155 | 1 | 2 |
| Kappa-type opioid receptor | Rattus norvegicus (Norway rat) | Ki | 7.0700 | 2 | 3 |
| Lactoperoxidase | Bos taurus (cattle) | IC50 | 5.0000 | 1 | 1 |
| Lysozyme C-1 | Rattus norvegicus (Norway rat) | IC50 | 9.0000 | 1 | 1 |
| Mcl-1 | Homo sapiens (human) | IC50 | 3.7733 | 1 | 1 |
| Melanocortin receptor 3 | Homo sapiens (human) | IC50 | 24.3430 | 1 | 1 |
| Melanocortin receptor 3 | Homo sapiens (human) | Ki | 21.2440 | 1 | 1 |
| Melanocortin receptor 4 | Homo sapiens (human) | IC50 | 15.2040 | 1 | 1 |
| Melanocortin receptor 4 | Homo sapiens (human) | Ki | 14.6190 | 1 | 1 |
| Melanocortin receptor 5 | Homo sapiens (human) | IC50 | 7.6170 | 1 | 1 |
| Melanocortin receptor 5 | Homo sapiens (human) | Ki | 7.1450 | 1 | 1 |
| Mu-type opioid receptor | Homo sapiens (human) | IC50 | 5.8325 | 1 | 4 |
| Mu-type opioid receptor | Cavia porcellus (domestic guinea pig) | Ki | 0.0400 | 1 | 1 |
| Mu-type opioid receptor | Homo sapiens (human) | Ki | 3.6567 | 3 | 6 |
| Mu-type opioid receptor | Rattus norvegicus (Norway rat) | Ki | 5.6025 | 3 | 4 |
| Multidrug and toxin extrusion protein 1 | Homo sapiens (human) | IC50 | 2.3000 | 1 | 1 |
| Multidrug and toxin extrusion protein 2 | Homo sapiens (human) | IC50 | 14.8000 | 1 | 1 |
| Multidrug resistance-associated protein 4 | Homo sapiens (human) | IC50 | 125.3308 | 1 | 12 |
| Muscarinic acetylcholine receptor M1 | Homo sapiens (human) | IC50 | 1.6455 | 3 | 10 |
| Muscarinic acetylcholine receptor M1 | Rattus norvegicus (Norway rat) | IC50 | 1.8905 | 2 | 4 |
| Muscarinic acetylcholine receptor M1 | Homo sapiens (human) | Ki | 0.5845 | 6 | 16 |
| Muscarinic acetylcholine receptor M1 | Rattus norvegicus (Norway rat) | Ki | 3.8689 | 4 | 6 |
| Muscarinic acetylcholine receptor M2 | Homo sapiens (human) | IC50 | 1.1237 | 1 | 7 |
| Muscarinic acetylcholine receptor M2 | Rattus norvegicus (Norway rat) | IC50 | 3.7270 | 2 | 2 |
| Muscarinic acetylcholine receptor M2 | Homo sapiens (human) | Ki | 0.8326 | 2 | 9 |
| Muscarinic acetylcholine receptor M2 | Rattus norvegicus (Norway rat) | Ki | 4.3886 | 5 | 6 |
| Muscarinic acetylcholine receptor M3 | Homo sapiens (human) | IC50 | 0.5500 | 1 | 9 |
| Muscarinic acetylcholine receptor M3 | Rattus norvegicus (Norway rat) | IC50 | 3.7270 | 2 | 2 |
| Muscarinic acetylcholine receptor M3 | Homo sapiens (human) | Ki | 0.5224 | 2 | 11 |
| Muscarinic acetylcholine receptor M3 | Rattus norvegicus (Norway rat) | Ki | 5.8245 | 2 | 3 |
| Muscarinic acetylcholine receptor M4 | Homo sapiens (human) | IC50 | 1.0978 | 1 | 10 |
| Muscarinic acetylcholine receptor M4 | Rattus norvegicus (Norway rat) | IC50 | 3.7270 | 2 | 2 |
| Muscarinic acetylcholine receptor M4 | Homo sapiens (human) | Ki | 0.4571 | 3 | 14 |
| Muscarinic acetylcholine receptor M4 | Rattus norvegicus (Norway rat) | Ki | 5.8245 | 2 | 3 |
| Muscarinic acetylcholine receptor M5 | Homo sapiens (human) | IC50 | 0.8442 | 1 | 11 |
| Muscarinic acetylcholine receptor M5 | Rattus norvegicus (Norway rat) | IC50 | 3.7270 | 2 | 2 |
| Muscarinic acetylcholine receptor M5 | Homo sapiens (human) | Ki | 0.8744 | 2 | 13 |
| Muscarinic acetylcholine receptor M5 | Rattus norvegicus (Norway rat) | Ki | 5.8245 | 2 | 3 |
| Myeloperoxidase | Homo sapiens (human) | IC50 | 4.3433 | 2 | 3 |
| N-acetyltransferase Eis | Mycobacterium tuberculosis H37Rv | IC50 | 6.2950 | 1 | 2 |
| N-acetyltransferase Eis | Mycobacterium tuberculosis H37Rv | Ki | 0.3900 | 1 | 1 |
| NADPH oxidase 1 | Homo sapiens (human) | IC50 | 17.0000 | 1 | 3 |
| Neuromedin-K receptor | Homo sapiens (human) | Ki | 0.4541 | 1 | 1 |
| neutrophil cytosol factor 1 | Homo sapiens (human) | IC50 | 50.0000 | 1 | 1 |
| Nuclear receptor subfamily 3 group C member 3 | Bos taurus (cattle) | IC50 | 21.5577 | 1 | 7 |
| Nuclear receptor subfamily 3 group C member 3 | Bos taurus (cattle) | Ki | 6.9507 | 1 | 6 |
| Pleiotropic ABC efflux transporter of multiple drugs | Saccharomyces cerevisiae S288C | IC50 | 5.6500 | 1 | 8 |
| Polyphenol oxidase 2 | Agaricus bisporus | IC50 | 100.0000 | 1 | 1 |
| Polyunsaturated fatty acid lipoxygenase ALOX15 | Oryctolagus cuniculus (rabbit) | IC50 | 8.7717 | 1 | 3 |
| Potassium channel subfamily K member 2 | Homo sapiens (human) | IC50 | 4.1000 | 1 | 2 |
| Potassium voltage-gated channel subfamily E member 1 | Homo sapiens (human) | IC50 | 50.1187 | 1 | 1 |
| Potassium voltage-gated channel subfamily H member 2 | Homo sapiens (human) | IC50 | 4.2816 | 25 | 66 |
| Potassium voltage-gated channel subfamily H member 2 | Homo sapiens (human) | Ki | 11.4336 | 4 | 10 |
| Potassium voltage-gated channel subfamily KQT member 1 | Homo sapiens (human) | IC50 | 50.1187 | 1 | 1 |
| Procathepsin L | Homo sapiens (human) | IC50 | 12.4425 | 1 | 4 |
| Prostaglandin G/H synthase 1 | Homo sapiens (human) | IC50 | 3.8320 | 1 | 1 |
| Protease | Human immunodeficiency virus 1 | IC50 | 125.0000 | 1 | 1 |
| Protease | Human immunodeficiency virus 1 | Ki | 50.0500 | 2 | 2 |
| Protein kinase C alpha type | Rattus norvegicus (Norway rat) | IC50 | 500.0000 | 1 | 1 |
| Protein kinase C beta type | Rattus norvegicus (Norway rat) | IC50 | 500.0000 | 1 | 1 |
| Protein kinase C delta type | Rattus norvegicus (Norway rat) | IC50 | 500.0000 | 1 | 1 |
| Protein kinase C epsilon type | Rattus norvegicus (Norway rat) | IC50 | 500.0000 | 1 | 1 |
| Protein kinase C eta type | Rattus norvegicus (Norway rat) | IC50 | 500.0000 | 1 | 1 |
| Protein kinase C gamma type | Rattus norvegicus (Norway rat) | IC50 | 500.0000 | 1 | 1 |
| Protein kinase C theta type | Rattus norvegicus (Norway rat) | IC50 | 500.0000 | 1 | 1 |
| Protein kinase C zeta type | Rattus norvegicus (Norway rat) | IC50 | 500.0000 | 1 | 1 |
| Protein orai-2 | Homo sapiens (human) | IC50 | 500.0000 | 2 | 2 |
| Protein orai-3 | Homo sapiens (human) | IC50 | 500.0000 | 2 | 2 |
| Receptor tyrosine-protein kinase erbB-2 | Homo sapiens (human) | IC50 | 19.3660 | 1 | 1 |
| Replicase polyprotein 1a | Severe acute respiratory syndrome-related coronavirus | IC50 | 12.4425 | 1 | 4 |
| Replicase polyprotein 1ab | Betacoronavirus England 1 | IC50 | 12.4425 | 1 | 4 |
| Replicase polyprotein 1ab | Human coronavirus 229E | IC50 | 12.4425 | 1 | 4 |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome coronavirus 2 | IC50 | 12.4425 | 1 | 4 |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome-related coronavirus | IC50 | 12.4425 | 1 | 4 |
| Retinal dehydrogenase 1 | Homo sapiens (human) | IC50 | 0.5242 | 1 | 1 |
| Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | Oryctolagus cuniculus (rabbit) | IC50 | 34.0000 | 1 | 2 |
| sentrin-specific protease 8 | Homo sapiens (human) | IC50 | 12.6500 | 2 | 2 |
| Sigma intracellular receptor 2 | Homo sapiens (human) | Ki | 0.0616 | 6 | 6 |
| Sigma intracellular receptor 2 | Rattus norvegicus (Norway rat) | Ki | 0.0721 | 11 | 11 |
| Sigma non-opioid intracellular receptor 1 | Homo sapiens (human) | IC50 | 0.1422 | 6 | 13 |
| Sigma non-opioid intracellular receptor 1 | Rattus norvegicus (Norway rat) | IC50 | 0.0013 | 4 | 5 |
| Sigma non-opioid intracellular receptor 1 | Cavia porcellus (domestic guinea pig) | Ki | 0.0049 | 37 | 37 |
| Sigma non-opioid intracellular receptor 1 | Homo sapiens (human) | Ki | 0.0171 | 37 | 48 |
| Sigma non-opioid intracellular receptor 1 | Rattus norvegicus (Norway rat) | Ki | 0.0148 | 7 | 7 |
| Sodium channel protein type 1 subunit alpha | Homo sapiens (human) | IC50 | 5.6500 | 2 | 2 |
| Sodium channel protein type 10 subunit alpha | Homo sapiens (human) | IC50 | 5.6500 | 2 | 2 |
| Sodium channel protein type 11 subunit alpha | Homo sapiens (human) | IC50 | 5.6500 | 2 | 2 |
| Sodium channel protein type 2 subunit alpha | Homo sapiens (human) | IC50 | 5.6500 | 2 | 2 |
| Sodium channel protein type 3 subunit alpha | Homo sapiens (human) | IC50 | 5.6500 | 2 | 2 |
| Sodium channel protein type 4 subunit alpha | Homo sapiens (human) | IC50 | 5.6500 | 2 | 2 |
| Sodium channel protein type 5 subunit alpha | Homo sapiens (human) | IC50 | 18.0632 | 4 | 4 |
| Sodium channel protein type 7 subunit alpha | Homo sapiens (human) | IC50 | 5.6500 | 2 | 2 |
| Sodium channel protein type 8 subunit alpha | Homo sapiens (human) | IC50 | 5.6500 | 2 | 2 |
| Sodium channel protein type 9 subunit alpha | Homo sapiens (human) | IC50 | 5.6500 | 2 | 2 |
| Sodium- and chloride-dependent betaine transporter | Rattus norvegicus (Norway rat) | IC50 | 8.3000 | 1 | 1 |
| Sodium- and chloride-dependent GABA transporter 1 | Rattus norvegicus (Norway rat) | IC50 | 8.3000 | 1 | 1 |
| Sodium- and chloride-dependent GABA transporter 2 | Rattus norvegicus (Norway rat) | IC50 | 8.3000 | 1 | 1 |
| Sodium- and chloride-dependent GABA transporter 3 | Rattus norvegicus (Norway rat) | IC50 | 8.3000 | 1 | 1 |
| Sodium-dependent dopamine transporter | Rattus norvegicus (Norway rat) | IC50 | 1.4791 | 1 | 2 |
| Sodium-dependent dopamine transporter | Rattus norvegicus (Norway rat) | Ki | 1.5138 | 3 | 4 |
| Sodium-dependent dopamine transporter | Homo sapiens (human) | IC50 | 1.6955 | 1 | 4 |
| Sodium-dependent dopamine transporter | Homo sapiens (human) | Ki | 1.3472 | 1 | 4 |
| Sodium-dependent noradrenaline transporter | Homo sapiens (human) | IC50 | 2.7652 | 1 | 9 |
| Sodium-dependent noradrenaline transporter | Homo sapiens (human) | Ki | 2.7441 | 3 | 11 |
| Sodium-dependent serotonin transporter | Homo sapiens (human) | IC50 | 2.1578 | 2 | 10 |
| Sodium-dependent serotonin transporter | Homo sapiens (human) | Ki | 2.1693 | 4 | 12 |
| Sodium-dependent serotonin transporter | Rattus norvegicus (Norway rat) | Ki | 0.0342 | 1 | 1 |
| Solute carrier family 22 member 1 | Rattus norvegicus (Norway rat) | IC50 | 24.0000 | 1 | 1 |
| Solute carrier family 22 member 1 | Homo sapiens (human) | IC50 | 52.8429 | 2 | 7 |
| Solute carrier family 22 member 2 | Homo sapiens (human) | IC50 | 7.9000 | 1 | 1 |
| Solute carrier family 22 member 2 | Rattus norvegicus (Norway rat) | IC50 | 32.0000 | 1 | 1 |
| Sphingomyelin phosphodiesterase | Homo sapiens (human) | IC50 | 11.0000 | 1 | 1 |
| Spike glycoprotein | Betacoronavirus England 1 | IC50 | 12.4425 | 1 | 4 |
| Spike glycoprotein | Severe acute respiratory syndrome-related coronavirus | IC50 | 12.4425 | 1 | 4 |
| Substance-K receptor | Homo sapiens (human) | IC50 | 27.1950 | 1 | 1 |
| Substance-K receptor | Homo sapiens (human) | Ki | 9.0650 | 1 | 1 |
| Substance-P receptor | Homo sapiens (human) | IC50 | 0.0003 | 10 | 11 |
| Substance-P receptor | Meriones unguiculatus (Mongolian gerbil) | IC50 | 0.0001 | 1 | 1 |
| Substance-P receptor | Homo sapiens (human) | Ki | 0.0011 | 5 | 5 |
| Transient receptor potential cation channel subfamily V member 1 | Rattus norvegicus (Norway rat) | Ki | 0.6083 | 3 | 3 |
| Transient receptor potential cation channel subfamily V member 2 | Rattus norvegicus (Norway rat) | Ki | 0.0050 | 1 | 1 |
| Transient receptor potential cation channel subfamily V member 4 | Rattus norvegicus (Norway rat) | Ki | 0.0050 | 1 | 1 |
| Transmembrane protease serine 2 | Homo sapiens (human) | IC50 | 12.4425 | 1 | 4 |
| Transporter | Rattus norvegicus (Norway rat) | Ki | 2.8193 | 2 | 3 |
| Trypanothione reductase | Trypanosoma cruzi | IC50 | 100.3667 | 2 | 6 |
| Trypanothione reductase | Trypanosoma cruzi | Ki | 50.4429 | 3 | 7 |
| Tyrosine-protein kinase Fyn | Homo sapiens (human) | IC50 | 7.1820 | 1 | 2 |
| Ubiquitin carboxyl-terminal hydrolase 1 | Homo sapiens (human) | IC50 | 8.0000 | 1 | 1 |
| ubiquitin-conjugating enzyme E2 N | Homo sapiens (human) | IC50 | 14.7900 | 2 | 2 |
| UDP-glucuronosyltransferase 1A9 | Homo sapiens (human) | Ki | 344.0000 | 1 | 1 |
| UDP-glucuronosyltransferase 2B7 | Homo sapiens (human) | Ki | 590.0000 | 1 | 1 |
| Vesicular acetylcholine transporter | Rattus norvegicus (Norway rat) | Ki | 0.3910 | 1 | 1 |
| Vitamin D-binding protein | Rattus norvegicus (Norway rat) | Ki | 0.0037 | 1 | 1 |
| Voltage-dependent L-type calcium channel subunit alpha-1C | Cavia porcellus (domestic guinea pig) | IC50 | 1.7000 | 1 | 1 |
| Voltage-dependent L-type calcium channel subunit alpha-1C | Homo sapiens (human) | IC50 | 82.4214 | 5 | 5 |
| Voltage-dependent L-type calcium channel subunit alpha-1D | Homo sapiens (human) | IC50 | 3.5000 | 4 | 4 |
| Voltage-dependent L-type calcium channel subunit alpha-1F | Homo sapiens (human) | IC50 | 3.5000 | 4 | 4 |
| Voltage-dependent L-type calcium channel subunit alpha-1S | Homo sapiens (human) | IC50 | 3.5000 | 4 | 4 |
| Voltage-dependent N-type calcium channel subunit alpha-1B | Homo sapiens (human) | IC50 | 18.0000 | 1 | 1 |
| WD repeat-containing protein 48 | Homo sapiens (human) | IC50 | 8.0000 | 1 | 1 |
| Zinc finger protein 664 | Cavia porcellus (domestic guinea pig) | Ki | 0.0066 | 1 | 1 |