Roles > potassium channel opener
Page last updated: 2024-08-05 15:00:47

potassium channel opener

A potassium channel modulator that opens the potassium channel.

ChEBI ID: 79085

Members (3)

MemberDefinitionClass
2-aminoethoxydiphenyl borateAn organoboron compound that is diphenylborane in which the borane hydrogen is replaced by a 2-aminoethoxy group.2-aminoethoxydiphenylborane
nicorandilA pyrimidinecarboxamide that is nicotinamide in which one of the hydrogens attached to the carboxamide nitrogen is replaced by a 2-(nitrooxy)ethyl group. It has both nitrate-like and ATP-sensitive potassium channel activator properties, and is used for the prevention and treatment of angina pectoris.nicorandil
ns 1619A member of the class of benzimidazoles that is 1,3-dihydro-2H-benzimidazol-2-one in which the hydrogens at positions 1 and 5 are replaced are replaced by 2-hydroxy-5-(trifluoromethyl)phenyl and trifluoromethyl groups, respectively. It is an opener/activator of the large-conductance calcium-activated potassium channel (Bkca).NS 1619

Research

Studies (2,322)

TimeframeStudies, Drugs with This Role(%)All Drugs %
pre-1990168 (7.24)18.7374
1990's430 (18.52)18.2507
2000's822 (35.40)29.6817
2010's745 (32.08)24.3611
2020's157 (6.76)2.80

Study Types

Publication TypeStudies, Drugs with this Role (%)All Drugs (%)
Trials212 (8.79%)5.53%
Reviews149 (6.18%)6.00%
Case Studies162 (6.72%)4.05%
Observational8 (0.33%)0.25%
Other1,880 (77.98%)84.16%

Protein Targets (85)

Potency Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1Homo sapiens (human)Potency39.810711
15-lipoxygenase, partialHomo sapiens (human)Potency10.291812
67.9K proteinVaccinia virusPotency14.125411
aldehyde dehydrogenase 1 family, member A1Homo sapiens (human)Potency37.554313
atrial natriuretic peptide receptor 1 precursorHomo sapiens (human)Potency37.933011
beta-2 adrenergic receptorHomo sapiens (human)Potency25.118911
Bloom syndrome protein isoform 1Homo sapiens (human)Potency39.810722
Chain A, 2-oxoglutarate OxygenaseHomo sapiens (human)Potency0.891311
Chain A, Beta-lactamaseEscherichia coli K-12Potency1.412511
Chain A, CruzipainTrypanosoma cruziPotency39.810711
Chain A, Ferritin light chainEquus caballus (horse)Potency19.952611
Chain A, HADH2 proteinHomo sapiens (human)Potency19.952611
Chain A, TYROSYL-DNA PHOSPHODIESTERASEHomo sapiens (human)Potency21.712312
Chain B, HADH2 proteinHomo sapiens (human)Potency19.952611
chromobox protein homolog 1Homo sapiens (human)Potency62.050622
cytochrome P450 2C19 precursorHomo sapiens (human)Potency2.053512
cytochrome P450 2C9 precursorHomo sapiens (human)Potency1.394812
cytochrome P450 3A4 isoform 1Homo sapiens (human)Potency14.219124
D(1A) dopamine receptorHomo sapiens (human)Potency25.787722
endonuclease IVEscherichia coliPotency25.118911
estrogen-related nuclear receptor alphaHomo sapiens (human)Potency14.146622
euchromatic histone-lysine N-methyltransferase 2Homo sapiens (human)Potency44.964712
EWS/FLI fusion proteinHomo sapiens (human)Potency33.597733
GABA theta subunitRattus norvegicus (Norway rat)Potency14.219112
Gamma-aminobutyric acid receptor subunit alpha-1Rattus norvegicus (Norway rat)Potency14.219112
Gamma-aminobutyric acid receptor subunit alpha-2Rattus norvegicus (Norway rat)Potency14.219112
Gamma-aminobutyric acid receptor subunit alpha-3Rattus norvegicus (Norway rat)Potency14.219112
Gamma-aminobutyric acid receptor subunit alpha-4Rattus norvegicus (Norway rat)Potency14.219112
Gamma-aminobutyric acid receptor subunit alpha-5Rattus norvegicus (Norway rat)Potency14.219112
Gamma-aminobutyric acid receptor subunit alpha-6Rattus norvegicus (Norway rat)Potency14.219112
Gamma-aminobutyric acid receptor subunit beta-1Rattus norvegicus (Norway rat)Potency14.219112
Gamma-aminobutyric acid receptor subunit beta-2Rattus norvegicus (Norway rat)Potency14.219112
Gamma-aminobutyric acid receptor subunit beta-3Rattus norvegicus (Norway rat)Potency14.219112
Gamma-aminobutyric acid receptor subunit deltaRattus norvegicus (Norway rat)Potency14.219112
Gamma-aminobutyric acid receptor subunit epsilonRattus norvegicus (Norway rat)Potency14.219112
Gamma-aminobutyric acid receptor subunit gamma-1Rattus norvegicus (Norway rat)Potency14.219112
Gamma-aminobutyric acid receptor subunit gamma-2Rattus norvegicus (Norway rat)Potency14.219112
Gamma-aminobutyric acid receptor subunit gamma-3Rattus norvegicus (Norway rat)Potency14.219112
Gamma-aminobutyric acid receptor subunit piRattus norvegicus (Norway rat)Potency14.219112
gemininHomo sapiens (human)Potency0.115811
GLI family zinc finger 3Homo sapiens (human)Potency30.733622
glucocerebrosidaseHomo sapiens (human)Potency17.782811
Histamine H2 receptorCavia porcellus (domestic guinea pig)Potency6.034228
histone acetyltransferase KAT2A isoform 1Homo sapiens (human)Potency31.622811
histone-lysine N-methyltransferase 2A isoform 2 precursorHomo sapiens (human)Potency1.778311
lethal factor (plasmid)Bacillus anthracis str. A2012Potency22.106012
Microtubule-associated protein tauHomo sapiens (human)Potency23.753122
mitogen-activated protein kinase 1Homo sapiens (human)Potency15.848911
neuropeptide S receptor isoform AHomo sapiens (human)Potency3.981111
NFKB1 protein, partialHomo sapiens (human)Potency10.000022
nonstructural protein 1Influenza A virus (A/WSN/1933(H1N1))Potency31.622811
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_aHomo sapiens (human)Potency9.520511
nuclear receptor ROR-gamma isoform 1Mus musculus (house mouse)Potency21.818523
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1Homo sapiens (human)Potency8.912511
peripheral myelin protein 22Rattus norvegicus (Norway rat)Potency20.314811
peripheral myelin protein 22 isoform 1Homo sapiens (human)Potency75.686311
phosphopantetheinyl transferaseBacillus subtilisPotency63.514412
polyunsaturated fatty acid lipoxygenase ALOX12Homo sapiens (human)Potency3.981111
Polyunsaturated fatty acid lipoxygenase ALOX15BHomo sapiens (human)Potency19.952611
Rap guanine nucleotide exchange factor 4Homo sapiens (human)Potency56.234111
RAR-related orphan receptor gammaMus musculus (house mouse)Potency1.188311
SMAD family member 2Homo sapiens (human)Potency3.790211
SMAD family member 3Homo sapiens (human)Potency3.790211
Smad3Homo sapiens (human)Potency8.912511
Spike glycoproteinSevere acute respiratory syndrome-related coronavirusPotency7.079511
TDP1 proteinHomo sapiens (human)Potency25.394728
thioredoxin reductaseRattus norvegicus (Norway rat)Potency38.603133
thyroid hormone receptor beta isoform aHomo sapiens (human)Potency28.183811
thyroid stimulating hormone receptorHomo sapiens (human)Potency34.913423
USP1 protein, partialHomo sapiens (human)Potency47.393612
v-jun sarcoma virus 17 oncogene homolog (avian)Homo sapiens (human)Potency0.001711
vitamin D3 receptor isoform VDRAHomo sapiens (human)Potency30.335214

Inhibition Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
ATP-binding cassette sub-family C member 3Homo sapiens (human)IC50133.000011
Bile salt export pumpHomo sapiens (human)IC50133.000011
Calcium-activated potassium channel subunit alpha-1Homo sapiens (human)IC505.888411
Canalicular multispecific organic anion transporter 1Homo sapiens (human)IC50133.000011
Heat shock protein HSP 90-alphaHomo sapiens (human)IC5042.160022
Multidrug resistance-associated protein 4Homo sapiens (human)IC50133.000011
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1Oryctolagus cuniculus (rabbit)IC5070.000011
Transient receptor potential cation channel subfamily M member 2Homo sapiens (human)IC501.880055

Activation Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
Transient receptor potential cation channel subfamily V member 1Homo sapiens (human)EC50129.000011

Other Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
Calcium-activated potassium channel subunit alpha-1Homo sapiens (human)EC40570.000022
Calcium-activated potassium channel subunit beta-1Homo sapiens (human)EC40790.000011
kelch-like ECH-associated protein 1Homo sapiens (human)Max_Activity_Concentration_uM 26.000011
Transient receptor potential cation channel subfamily V member 1Homo sapiens (human)Activity10.000011
Transient receptor potential cation channel subfamily V member 2Homo sapiens (human)Activity10.000011
Transient receptor potential cation channel subfamily V member 3Homo sapiens (human)Activity10.000011