calcium fructoborate

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

calcium fructoborate: a boron-based nutritional supplement with antioxidant activity [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	85076954
MeSH ID	M0494123

Synonyms (6)

Synonym
borate(1-), bis(beta-d-fructofuranosato(2-)-kappao2,kappao3)-, calcium (2:1), (t-4)-
250141-42-5
calcium fructoborate
7ew2ez38ls ,
unii-7ew2ez38ls
calcium;5,5',7,7'-tetrakis(hydroxymethyl)-3,3'-spirobi[2,4,6-trioxa-3-boranuidabicyclo[3.3.0]octane]-8,8'-diol

Research Excerpts

Overview

Calcium fructoborate is a boron-based nutritional supplement.

Excerpt	Reference	Relevance
"Calcium fructoborate is a boron-based nutritional supplement. "	( Calcium fructoborate--potential anti-inflammatory agent. Rotaru, P; Scorei, RI, 2011)	3.25

Effects

Excerpt	Reference	Relevance
"Calcium fructoborate (CFB) has been reported as supporting healthy inflammatory response. "	( Effects of Calcium Fructoborate on Levels of C-Reactive Protein, Total Cholesterol, Low-Density Lipoprotein, Triglycerides, IL-1β, IL-6, and MCP-1: a Double-blind, Placebo-controlled Clinical Study. Bejenaru, C; Bejenaru, LE; Biţă, A; Croitoru, O; Mogoşanu, GD; Neamţu, J; Pietrzkowski, Z; Reyes-Izquierdo, T; Rogoveanu, OC; Scorei, ID; Scorei, RI, 2015)	2.25

Toxicity

Excerpt	Reference	Relevance
" There were no adverse changes in hematology, coagulation, clinical chemistry, or urinalysis parameters in male or female rats considered the result of test substance administration."	( Subchronic and genetic safety evaluation of a calcium fructoborate in rats. Heimbach, JT; Hunter, JM; Marone, PA; Nemzer, B, 2016)	0.69

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (24)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	6 (25.00)	29.6817
2010's	14 (58.33)	24.3611
2020's	4 (16.67)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 31.62

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	31.62 (24.57)
Research Supply Index	3.47 (2.92)
Research Growth Index	4.80 (4.65)
Search Engine Demand Index	76.81 (26.88)
Search Engine Supply Index	3.95 (0.95)

This Compound (31.62)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	6 (24.00%)	5.53%
Reviews	5 (20.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	14 (56.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Trials	Classes	Roles
pyrogallol benzenetriol : A triol in which three hydroxy groups are substituted onto a benzene ring.	2.94	1	0	benzenetriol; phenolic donor	plant metabolite
nimesulide nimesulide: structure. nimesulide : An aromatic ether having phenyl and 2-methylsulfonamido-5-nitrophenyl as the two aryl groups.	3.43	1	1	aromatic ether; C-nitro compound; sulfonamide	cyclooxygenase 2 inhibitor; non-steroidal anti-inflammatory drug
9,10-dimethyl-1,2-benzanthracene 9,10-Dimethyl-1,2-benzanthracene: Polycyclic aromatic hydrocarbon found in tobacco smoke that is a potent carcinogen.. 7,12-dimethyltetraphene : A tetraphene having methyl substituents at the 7- and 12-positions. It is a potent carcinogen and is present in tobacco smoke.	2.31	1	0	ortho-fused polycyclic arene; tetraphenes	carcinogenic agent
phenylalanine Phenylalanine: An essential aromatic amino acid that is a precursor of MELANIN; DOPAMINE; noradrenalin (NOREPINEPHRINE), and THYROXINE.. L-phenylalanine : The L-enantiomer of phenylalanine.. phenylalanine : An aromatic amino acid that is alanine in which one of the methyl hydrogens is substituted by a phenyl group.	2.25	1	0	amino acid zwitterion; erythrose 4-phosphate/phosphoenolpyruvate family amino acid; L-alpha-amino acid; phenylalanine; proteinogenic amino acid	algal metabolite; EC 3.1.3.1 (alkaline phosphatase) inhibitor; Escherichia coli metabolite; human xenobiotic metabolite; micronutrient; mouse metabolite; nutraceutical; plant metabolite; Saccharomyces cerevisiae metabolite
boric acid [no description available]	7.04	1	0	boric acids	astringent
fibrinogen Fibrinogen: Plasma glycoprotein clotted by thrombin, composed of a dimer of three non-identical pairs of polypeptide chains (alpha, beta, gamma) held together by disulfide bonds. Fibrinogen clotting is a sol-gel change involving complex molecular arrangements: whereas fibrinogen is cleaved by thrombin to form polypeptides A and B, the proteolytic action of other enzymes yields different fibrinogen degradation products.. D-iditol : The D-enantiomer of iditol.	4.37	1	1	iditol	fungal metabolite
dihydrorhodamine 123 dihydrorhodamine 123: uncharged & nonfluorescent derivative of the laser dye rhodamine 123; flow cytometric indicator for respiratory burst activity in neutrophil granulocytes	2.94	1	0
n-formylmethionine leucyl-phenylalanine N-Formylmethionine Leucyl-Phenylalanine: A formylated tripeptide originally isolated from bacterial filtrates that is positively chemotactic to polymorphonuclear leucocytes, and causes them to release lysosomal enzymes and become metabolically activated.. N-formyl-L-methionyl-L-leucyl-L-phenylalanine : A tripeptide composed of L-Met, L-Leu and L-Phe in a linear sequence with a formyl group at the amino terminus. It acts as a potent inducer of leucocyte chemotaxis and macrophage activator as well as a ligand for the FPR receptor.	2.03	1	0	tripeptide
resveratrol trans-resveratrol : A resveratrol in which the double bond has E configuration.	8.47	1	1	resveratrol	antioxidant; phytoalexin; plant metabolite; quorum sensing inhibitor; radical scavenger
stilbenes Stilbenes: Organic compounds that contain 1,2-diphenylethylene as a functional group.. trans-stilbene : The trans-isomer of stilbene.	3.47	1	1	stilbene
D-fructopyranose [no description available]	12.52	24	6	cyclic hemiketal; D-fructose; fructopyranose	sweetening agent
boron Boron: A trace element with the atomic symbol B, atomic number 5, and atomic weight [10.806; 10.821]. Boron-10, an isotope of boron, is used as a neutron absorber in BORON NEUTRON CAPTURE THERAPY.	8.56	2	0	boron group element atom; metalloid atom; nonmetal atom	micronutrient
cytochrome c-t Cytochromes c: Cytochromes of the c type that are found in eukaryotic MITOCHONDRIA. They serve as redox intermediates that accept electrons from MITOCHONDRIAL ELECTRON TRANSPORT COMPLEX III and transfer them to MITOCHONDRIAL ELECTRON TRANSPORT COMPLEX IV.	2.04	1	0
natriuretic peptide, brain Natriuretic Peptide, Brain: A PEPTIDE that is secreted by the BRAIN and the HEART ATRIA, stored mainly in cardiac ventricular MYOCARDIUM. It can cause NATRIURESIS; DIURESIS; VASODILATION; and inhibits secretion of RENIN and ALDOSTERONE. It improves heart function. It contains 32 AMINO ACIDS.	3.47	1	1	polypeptide

Condition	Relationship Strength	Studies	Trials
Cancer of Colon [description not available]	2.41	1	0
Colonic Neoplasms Tumors or cancer of the COLON.	2.41	1	0
Cancer of Skin [description not available]	2.69	2	0
Skin Neoplasms Tumors or cancer of the SKIN.	2.69	2	0
Innate Inflammatory Response [description not available]	7.6	4	2
Inflammation A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.	7.6	4	2
Canine Diseases [description not available]	4.45	1	1
Arthritis, Degenerative [description not available]	6.46	3	3
Ache [description not available]	4.45	1	1
Osteoarthritis A progressive, degenerative joint disease, the most common form of arthritis, especially in older persons. The disease is thought to result not from the aging process but from biochemical changes and biomechanical stresses affecting articular cartilage. In the foreign literature it is often called osteoarthrosis deformans.	6.46	3	3
Pain An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.	4.45	1	1
Bone Diseases Diseases of BONES.	3.92	1	0
Joint Pain [description not available]	4.4	1	1
Osteoarthritis of Knee [description not available]	4.4	1	1
Arthralgia Pain in the joint.	4.4	1	1
Osteoarthritis, Knee Noninflammatory degenerative disease of the knee joint consisting of three large categories: conditions that block normal synchronous movement, conditions that produce abnormal pathways of motion, and conditions that cause stress concentration resulting in changes to articular cartilage. (Crenshaw, Campbell's Operative Orthopaedics, 8th ed, p2019)	4.4	1	1
Cardiovascular Diseases Pathological conditions involving the CARDIOVASCULAR SYSTEM including the HEART; the BLOOD VESSELS; or the PERICARDIUM.	3.04	1	0
Breast Cancer [description not available]	7.48	2	0
Breast Neoplasms Tumors or cancer of the human BREAST.	2.48	2	0
Benign Neoplasms [description not available]	3.85	2	0
Neoplasms New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.	3.85	2	0
Body Weight The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.	2.06	1	0
Dyslipidemia [description not available]	9.37	1	1
Dyslipidemias Abnormalities in the serum levels of LIPIDS, including overproduction or deficiency. Abnormal serum lipid profiles may include high total CHOLESTEROL, high TRIGLYCERIDES, low HIGH DENSITY LIPOPROTEIN CHOLESTEROL, and elevated LOW DENSITY LIPOPROTEIN CHOLESTEROL.	4.37	1	1
Polyarthritis [description not available]	2.96	1	0
Arthritis Acute or chronic inflammation of JOINTS.	2.96	1	0
Angina Pectoris, Stable [description not available]	3.47	1	1
Angina, Stable Persistent and reproducible chest discomfort usually precipitated by a physical exertion that dissipates upon cessation of such an activity. The symptoms are manifestations of MYOCARDIAL ISCHEMIA.	3.47	1	1

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