Compounds > nor-beta-lapachone
Page last updated: 2024-12-10

nor-beta-lapachone

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Description

nor-beta-lapachone: has antineoplastic activity; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID5249188
CHEMBL ID394882
SCHEMBL ID107599
MeSH IDM0576816

Synonyms (11)

Synonym
CHEMBL394882
nor-beta-lapachone
52436-88-1
naphtho[1,2-b]furan-4,5-dione, 2,3-dihydro-2,2-dimethyl-
SCHEMBL107599
DTXSID40413170
beta--nor-lapachone
CS-0498881
HY-146067
nor-beta--lapachone
GLXC-25658
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (159)

Assay IDTitleYearJournalArticle
AID1867408Indifferent antifungal activity against fluconazole sensitive Candida glabrata ATCC 2001 assessed as fractional inhibitory concentration incubated for 48 hrs in presence of lapachone by checkboard assay based microplate reader analysis2022Bioorganic & medicinal chemistry, 06-01, Volume: 63Effects of β-lapachone and β-nor-lapachone on multidrug efflux transporters and biofilms of Candida glabrata.
AID1416350Cytotoxicity against human PC3 cells assessed as decrease in cell viability after 96 hrs by MTT assay2017MedChemComm, Oct-01, Volume: 8, Issue:10
Encapsulation of nor-β-lapachone into poly(d,l)-lactide-
AID1416331Cytotoxicity against human DU145 cells assessed as decrease in cell viability after 72 hrs by MTT assay2017MedChemComm, Oct-01, Volume: 8, Issue:10
Encapsulation of nor-β-lapachone into poly(d,l)-lactide-
AID481799Cytotoxicity against human PBMC after 72 hrs by alamar blue assay2010Bioorganic & medicinal chemistry, May-01, Volume: 18, Issue:9
The evaluation of quinonoid compounds against Trypanosoma cruzi: synthesis of imidazolic anthraquinones, nor-beta-lapachone derivatives and beta-lapachone-based 1,2,3-triazoles.
AID1416347Cytotoxicity against human PC3 cells assessed as decrease in cell viability using compound loaded PLGA microcapsule after 24 hrs by MTT assay2017MedChemComm, Oct-01, Volume: 8, Issue:10
Encapsulation of nor-β-lapachone into poly(d,l)-lactide-
AID1416328Cytotoxicity against human SF295 cells assessed as decrease in cell viability after 72 hrs by MTT assay2017MedChemComm, Oct-01, Volume: 8, Issue:10
Encapsulation of nor-β-lapachone into poly(d,l)-lactide-
AID1849793Cytotoxicity against human HL-60 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay2021European journal of medicinal chemistry, Jan-15, Volume: 210A comprehensive review on β-lapachone: Mechanisms, structural modifications, and therapeutic potentials.
AID735528Ratio of cisplatin IC50 to compound IC50 for human WHCO1 cells after 24 hrs by MTT assay2013European journal of medicinal chemistry, Apr, Volume: 62Cytotoxicity of lapachol, β-lapachone and related synthetic 1,4-naphthoquinones against oesophageal cancer cells.
AID1867428Inhibition of fluconazole resistant Saccharomyces cerevisiae overexpressing CgCdr2p transporter ATPase activity assessed as reduction in inorganic phosphate release in presence of ATP incubated for 1 hr by Fiske and Sub barrow method2022Bioorganic & medicinal chemistry, 06-01, Volume: 63Effects of β-lapachone and β-nor-lapachone on multidrug efflux transporters and biofilms of Candida glabrata.
AID1416351Cytotoxicity against human PC3 cells assessed as decrease in cell viability using compound loaded PLGA microcapsule after 96 hrs by MTT assay2017MedChemComm, Oct-01, Volume: 8, Issue:10
Encapsulation of nor-β-lapachone into poly(d,l)-lactide-
AID735529Cytotoxicity against human WHCO1 cells after 24 hrs by MTT assay2013European journal of medicinal chemistry, Apr, Volume: 62Cytotoxicity of lapachol, β-lapachone and related synthetic 1,4-naphthoquinones against oesophageal cancer cells.
AID1867449Indifferent antifungal activity against fluconazole resistant Candida glabrata 109 overexpressing CgCdr1p transporter assessed as fractional inhibitory concentration index incubated for 48 hrs by checkboard assay based microplate reader analysis2022Bioorganic & medicinal chemistry, 06-01, Volume: 63Effects of β-lapachone and β-nor-lapachone on multidrug efflux transporters and biofilms of Candida glabrata.
AID1597870Selectivity index, ratio of IC50 for mouse J774.A1 cells to MIC for Mycobacterium tuberculosis INH R2
AID1867403Antifungal activity against fluconazole resistant Candida glabrata 109 overexpressing CgCdr1p transporter assessed as reduction in fungal growth incubated for 48 hrs by checkboard assay based microplate reader analysis2022Bioorganic & medicinal chemistry, 06-01, Volume: 63Effects of β-lapachone and β-nor-lapachone on multidrug efflux transporters and biofilms of Candida glabrata.
AID1867431Hemolytic activity in human erythrocytes assessed as haemoglobin release at 50 ug/ml incubated for 1 hr by absorbance based method2022Bioorganic & medicinal chemistry, 06-01, Volume: 63Effects of β-lapachone and β-nor-lapachone on multidrug efflux transporters and biofilms of Candida glabrata.
AID1867435Inhibition of fluconazole sensitive Candida glabrata ATCC 2001 bacterial cell adhesion to polystyrene at 200 ug/ml incubated for 90 mins by MTT assay2022Bioorganic & medicinal chemistry, 06-01, Volume: 63Effects of β-lapachone and β-nor-lapachone on multidrug efflux transporters and biofilms of Candida glabrata.
AID1416345Cytotoxicity against human PC3M cells assessed as decrease in cell viability using compound loaded PLGA microcapsule after 96 hrs by MTT assay2017MedChemComm, Oct-01, Volume: 8, Issue:10
Encapsulation of nor-β-lapachone into poly(d,l)-lactide-
AID1849796Cytotoxicity against human SF-295 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay2021European journal of medicinal chemistry, Jan-15, Volume: 210A comprehensive review on β-lapachone: Mechanisms, structural modifications, and therapeutic potentials.
AID1867427Inhibition of fluconazole resistant Saccharomyces cerevisiae overexpressing CgCdr1p transporter ATPase activity assessed as reduction in inorganic phosphate release in presence of ATP incubated for 1 hr by Fiske and Sub barrow method2022Bioorganic & medicinal chemistry, 06-01, Volume: 63Effects of β-lapachone and β-nor-lapachone on multidrug efflux transporters and biofilms of Candida glabrata.
AID1867438Induction of ROS generation in fluconazole resistant Candida glabrata 109 overexpressing CgCdr1p transporter assessed as fold increase in ROS production at 200 ug/ml incubated for 48 hrs by DCFH-DA dye based fluorescence assay2022Bioorganic & medicinal chemistry, 06-01, Volume: 63Effects of β-lapachone and β-nor-lapachone on multidrug efflux transporters and biofilms of Candida glabrata.
AID1867436Antibiofilm activity against fluconazole resistant Candida glabrata 109 overexpressing CgCdr1p transporter assessed as inhibition of biofilm formation at 200 ug/ml incubated for 48 hrs2022Bioorganic & medicinal chemistry, 06-01, Volume: 63Effects of β-lapachone and β-nor-lapachone on multidrug efflux transporters and biofilms of Candida glabrata.
AID1416340Cytotoxicity against human PC3 cells assessed as decrease in cell viability using compound loaded PLGA microcapsule after 72 hrs by MTT assay2017MedChemComm, Oct-01, Volume: 8, Issue:10
Encapsulation of nor-β-lapachone into poly(d,l)-lactide-
AID1597875Antimycobacterial activity against isoniazid resistant Mycobacterium tuberculosis measured after 7 days by resazurin microtiter assay
AID1867448Indifferent antifungal activity against fluconazole resistant Candida glabrata 109 overexpressing CgCdr1p transporter assessed as fractional inhibitory concentration incubated for 48 hrs in presence of fluconazole by checkboard assay based microplate read2022Bioorganic & medicinal chemistry, 06-01, Volume: 63Effects of β-lapachone and β-nor-lapachone on multidrug efflux transporters and biofilms of Candida glabrata.
AID567424DNA damage index, DNA damage in human HCT8 cells to DNA damage in human HL60 cells with FPG/ENDO3 DNA repair enzymes in presence of N-acetylcytosine2011European journal of medicinal chemistry, Jan, Volume: 46, Issue:1
Synthesis and evaluation of quinonoid compounds against tumor cell lines.
AID567419DNA damage index, DNA damage in human HL60 cells to DNA damage in human HL60 cells with FPG/ENDO3 DNA repair enzymes2011European journal of medicinal chemistry, Jan, Volume: 46, Issue:1
Synthesis and evaluation of quinonoid compounds against tumor cell lines.
AID1416337Cytotoxicity against human HCT116 cells assessed as decrease in cell viability using compound loaded PLGA microcapsule after 72 hrs by MTT assay2017MedChemComm, Oct-01, Volume: 8, Issue:10
Encapsulation of nor-β-lapachone into poly(d,l)-lactide-
AID1416341Cytotoxicity against human PBMC assessed as decrease in cell viability using compound loaded PLGA microcapsule after 72 hrs by Alamar blue assay2017MedChemComm, Oct-01, Volume: 8, Issue:10
Encapsulation of nor-β-lapachone into poly(d,l)-lactide-
AID660266Trypanocidal activity against bloodstream form of Trypanosoma cruzi Y isolated from albino mouse blood after 24 hrs by neubauer chamber analysis2012European journal of medicinal chemistry, Jun, Volume: 52On the search for potential anti-Trypanosoma cruzi drugs: synthesis and biological evaluation of 2-hydroxy-3-methylamino and 1,2,3-triazolic naphthoquinoidal compounds obtained by click chemistry reactions.
AID567500Induction of lipid peroxidation in human SF295 cells assessed as increase in TBARS formation at 5 uM after 24 hrs2011European journal of medicinal chemistry, Jan, Volume: 46, Issue:1
Synthesis and evaluation of quinonoid compounds against tumor cell lines.
AID1867407Additive antifungal activity against fluconazole resistant Candida glabrata 109 overexpressing CgCdr1p transporter assessed as fractional inhibitory concentration incubated for 48 hrs in presence of lapachone by checkboard assay based microplate reader an2022Bioorganic & medicinal chemistry, 06-01, Volume: 63Effects of β-lapachone and β-nor-lapachone on multidrug efflux transporters and biofilms of Candida glabrata.
AID567412Induction of lipid peroxidation in human HL60 cells assessed as increase in TBARS formation at 5 uM after 24 hrs in presence of N-acetylcytosine2011European journal of medicinal chemistry, Jan, Volume: 46, Issue:1
Synthesis and evaluation of quinonoid compounds against tumor cell lines.
AID1867421Induction of ROS generation in fluconazole resistant Saccharomyces cerevisiae overexpressing CgCdr1p transporter assessed as fold increase in ROS level incubated for 90 mins by DCFH-DA dye based fluorescence assay2022Bioorganic & medicinal chemistry, 06-01, Volume: 63Effects of β-lapachone and β-nor-lapachone on multidrug efflux transporters and biofilms of Candida glabrata.
AID1867461Additive antifungal activity against fluconazole resistant Saccharomyces cerevisiae overexpressing CgCdr1p transporter assessed as fractional inhibitory concentration in presence of fluconazole incubated for 48 hrs by checkboard assay based microplate rea2022Bioorganic & medicinal chemistry, 06-01, Volume: 63Effects of β-lapachone and β-nor-lapachone on multidrug efflux transporters and biofilms of Candida glabrata.
AID1416334Cytotoxicity against human PBMC assessed as decrease in cell viability after 72 hrs by Alamar blue assay2017MedChemComm, Oct-01, Volume: 8, Issue:10
Encapsulation of nor-β-lapachone into poly(d,l)-lactide-
AID301688Cytotoxicity against human PC3 cells after 72 hrs by MTT assay2007Bioorganic & medicinal chemistry, Nov-15, Volume: 15, Issue:22
Synthesis and potent antitumor activity of new arylamino derivatives of nor-beta-lapachone and nor-alpha-lapachone.
AID567422DNA damage index, DNA damage in human MDA-MB-435 cells to DNA damage in human HL60 cells with FPG/ENDO3 DNA repair enzymes in presence of N-acetylcytosine2011European journal of medicinal chemistry, Jan, Volume: 46, Issue:1
Synthesis and evaluation of quinonoid compounds against tumor cell lines.
AID1416349Cytotoxicity against human DU145 cells assessed as decrease in cell viability using compound loaded PLGA microcapsule after 24 hrs by MTT assay2017MedChemComm, Oct-01, Volume: 8, Issue:10
Encapsulation of nor-β-lapachone into poly(d,l)-lactide-
AID301685Cytotoxicity against human MDA-MB-435 cells after 72 hrs by MTT assay2007Bioorganic & medicinal chemistry, Nov-15, Volume: 15, Issue:22
Synthesis and potent antitumor activity of new arylamino derivatives of nor-beta-lapachone and nor-alpha-lapachone.
AID1597872Selectivity index, ratio of IC50 for mouse J774.A1 cells to MIC for Mycobacterium tuberculosis H37Rv
AID567496Cytotoxicity against human HCT8 cells after 72 hrs by MTT assay2011European journal of medicinal chemistry, Jan, Volume: 46, Issue:1
Synthesis and evaluation of quinonoid compounds against tumor cell lines.
AID445397Cytotoxicity against human SF295 cells after 72 hrs by MTT assay2010Journal of medicinal chemistry, Jan-14, Volume: 53, Issue:1
3-arylamino and 3-alkoxy-nor-beta-lapachone derivatives: synthesis and cytotoxicity against cancer cell lines.
AID567420DNA damage index, DNA damage in human HL60 cells to DNA damage in human HL60 cells with FPG/ENDO3 DNA repair enzymes in presence of N-acetylcytosine2011European journal of medicinal chemistry, Jan, Volume: 46, Issue:1
Synthesis and evaluation of quinonoid compounds against tumor cell lines.
AID1191933Activity of human recombinant NQO1 assessed as ratio of kcat to Km preincubated for 3 mins before NADPH addition at 0.1 to 5 umol/L by NADPH recycling assay2015Bioorganic & medicinal chemistry letters, Mar-15, Volume: 25, Issue:6
Synthesis and evaluation of (±)-dunnione and its ortho-quinone analogues as substrates for NAD(P)H:quinone oxidoreductase 1 (NQO1).
AID1441539Substrate activity at recombinant human NQO1 expressed in Escherichia coli assessed as compound reduction rate by measuring NADPH consumption per umol of enzyme preincubated for 3 mins followed by NADPH addition measured for 5 mins at 2 sec time interval 2017European journal of medicinal chemistry, Mar-31, Volume: 129Discovery of quinone-directed antitumor agents selectively bioactivated by NQO1 over CPR with improved safety profile.
AID445396Cytotoxicity against human HCT8 cells after 72 hrs by MTT assay2010Journal of medicinal chemistry, Jan-14, Volume: 53, Issue:1
3-arylamino and 3-alkoxy-nor-beta-lapachone derivatives: synthesis and cytotoxicity against cancer cell lines.
AID1867385Indifferent antifungal activity against fluconazole resistant Candida glabrata 109 overexpressing CgCdr1p transporter assessed as reduction in fungal growth incubated for 48 hrs by checkboard assay based microplate reader analysis2022Bioorganic & medicinal chemistry, 06-01, Volume: 63Effects of β-lapachone and β-nor-lapachone on multidrug efflux transporters and biofilms of Candida glabrata.
AID1867446Indifferent antifungal activity against fluconazole resistant Candida glabrata 109 overexpressing CgCdr1p transporter assessed as fractional inhibitory concentration incubated for 48 hrs in presence of lapachone by checkboard assay based microplate reader2022Bioorganic & medicinal chemistry, 06-01, Volume: 63Effects of β-lapachone and β-nor-lapachone on multidrug efflux transporters and biofilms of Candida glabrata.
AID1867404Antifungal activity against fluconazole sensitive Candida glabrata ATCC 2001 assessed as reduction in fungal growth incubated for 48 hrs by checkboard assay based microplate reader analysis2022Bioorganic & medicinal chemistry, 06-01, Volume: 63Effects of β-lapachone and β-nor-lapachone on multidrug efflux transporters and biofilms of Candida glabrata.
AID1597874Antimycobacterial activity against isoniazid resistant Mycobacterium tuberculosis ATCC 35822 after 7 days by resazurin microtiter assay
AID1867433Hemolytic activity in human erythrocytes assessed as haemoglobin release at 50 ug/ml incubated for 1 hr in presence of fluconazole by absorbance based method2022Bioorganic & medicinal chemistry, 06-01, Volume: 63Effects of β-lapachone and β-nor-lapachone on multidrug efflux transporters and biofilms of Candida glabrata.
AID567498Induction of lipid peroxidation in human HL60 cells assessed as increase in TBARS formation at 5 uM after 24 hrs2011European journal of medicinal chemistry, Jan, Volume: 46, Issue:1
Synthesis and evaluation of quinonoid compounds against tumor cell lines.
AID1597869Selectivity index, ratio of IC50 for mouse J774.A1 cells to MIC for Mycobacterium tuberculosis INH R1 ATCC 35822
AID567499Induction of lipid peroxidation in human HCT8 cells assessed as increase in TBARS formation at 5 uM after 24 hrs2011European journal of medicinal chemistry, Jan, Volume: 46, Issue:1
Synthesis and evaluation of quinonoid compounds against tumor cell lines.
AID1867414Indifferent antifungal activity against fluconazole sensitive Candida glabrata ATCC 2001 assessed as fractional inhibitory concentration index incubated for 48 hrs by checkboard assay based microplate reader analysis2022Bioorganic & medicinal chemistry, 06-01, Volume: 63Effects of β-lapachone and β-nor-lapachone on multidrug efflux transporters and biofilms of Candida glabrata.
AID1416336Cytotoxicity against human OVCAR8 cells assessed as decrease in cell viability using compound loaded PLGA microcapsule after 72 hrs by MTT assay2017MedChemComm, Oct-01, Volume: 8, Issue:10
Encapsulation of nor-β-lapachone into poly(d,l)-lactide-
AID1416344Cytotoxicity against human PC3M cells assessed as decrease in cell viability after 96 hrs by MTT assay2017MedChemComm, Oct-01, Volume: 8, Issue:10
Encapsulation of nor-β-lapachone into poly(d,l)-lactide-
AID1867424Effect on efflux pump function in fluconazole resistant Saccharomyces cerevisiae overexpressing CgCdr1p transporter assessed as accumulation of Nile red fluorescence incubated for 1 hr by fluorescence based assay2022Bioorganic & medicinal chemistry, 06-01, Volume: 63Effects of β-lapachone and β-nor-lapachone on multidrug efflux transporters and biofilms of Candida glabrata.
AID567493Cytotoxicity against human PBMC cells after 72 hrs by Alamar Blue assay2011European journal of medicinal chemistry, Jan, Volume: 46, Issue:1
Synthesis and evaluation of quinonoid compounds against tumor cell lines.
AID744767Selectivity index, ratio of CC50 for Swiss mouse peritoneal macrophages to IC50 for antimony-sensitive Leishmania infantum MCAN/BR/2002/BH400 promastigote2013European journal of medicinal chemistry, May, Volume: 63Potent naphthoquinones against antimony-sensitive and -resistant Leishmania parasites: synthesis of novel α- and nor-α-lapachone-based 1,2,3-triazoles by copper-catalyzed azide-alkyne cycloaddition.
AID1867458Additive antifungal activity against fluconazole resistant Saccharomyces cerevisiae overexpressing CgCdr1p transporter assessed as reduction in fungal growth incubated for 48 hrs in presence of fluconazole by checkboard assay based microplate reader analy2022Bioorganic & medicinal chemistry, 06-01, Volume: 63Effects of β-lapachone and β-nor-lapachone on multidrug efflux transporters and biofilms of Candida glabrata.
AID1867412Indifferent antifungal activity against fluconazole sensitive Candida glabrata ATCC 2001 assessed as fractional inhibitory concentration incubated for 48 hrs in presence of fluconazole by checkboard assay based microplate reader analysis2022Bioorganic & medicinal chemistry, 06-01, Volume: 63Effects of β-lapachone and β-nor-lapachone on multidrug efflux transporters and biofilms of Candida glabrata.
AID445398Cytotoxicity against human PBMC after 72 hrs by alamar blue assay2010Journal of medicinal chemistry, Jan-14, Volume: 53, Issue:1
3-arylamino and 3-alkoxy-nor-beta-lapachone derivatives: synthesis and cytotoxicity against cancer cell lines.
AID1416335Cytotoxicity against human SF295 cells assessed as decrease in cell viability using compound loaded PLGA microcapsule after 72 hrs by MTT assay2017MedChemComm, Oct-01, Volume: 8, Issue:10
Encapsulation of nor-β-lapachone into poly(d,l)-lactide-
AID1867447Indifferent antifungal activity against fluconazole resistant Candida glabrata 109 overexpressing CgCdr1p transporter assessed as reduction in fungal growth incubated for 48 hrs in presence of fluconazole by checkboard assay based microplate reader analys2022Bioorganic & medicinal chemistry, 06-01, Volume: 63Effects of β-lapachone and β-nor-lapachone on multidrug efflux transporters and biofilms of Candida glabrata.
AID567503Induction of lipid peroxidation in human SF295 cells assessed as increase in TBARS formation at 5 uM after 24 hrs in presence of N-acetylcytosine2011European journal of medicinal chemistry, Jan, Volume: 46, Issue:1
Synthesis and evaluation of quinonoid compounds against tumor cell lines.
AID1867410Indifferent antifungal activity against fluconazole sensitive Candida glabrata ATCC 2001 assessed as reduction in fungal growth incubated for 48 hrs in presence of fluconazole by checkboard assay based microplate reader analysis2022Bioorganic & medicinal chemistry, 06-01, Volume: 63Effects of β-lapachone and β-nor-lapachone on multidrug efflux transporters and biofilms of Candida glabrata.
AID1867387Antibiofilm activity against fluconazole sensitive Candida glabrata ATCC 2001 assessed as reduction in metabolic activity up to 200 ug/ml incubated for 48 hrs2022Bioorganic & medicinal chemistry, 06-01, Volume: 63Effects of β-lapachone and β-nor-lapachone on multidrug efflux transporters and biofilms of Candida glabrata.
AID1416329Cytotoxicity against human OVCAR8 cells assessed as decrease in cell viability after 72 hrs by MTT assay2017MedChemComm, Oct-01, Volume: 8, Issue:10
Encapsulation of nor-β-lapachone into poly(d,l)-lactide-
AID1853312Induction of apoptosis in human HCT-116 cells assessed as increase in intracellular ROS level at 4 uM incubated for 5 hrs by CM-H2DCFDA staining based flow cytometry
AID1416332Cytotoxicity against human PC3M cells assessed as decrease in cell viability after 72 hrs by MTT assay2017MedChemComm, Oct-01, Volume: 8, Issue:10
Encapsulation of nor-β-lapachone into poly(d,l)-lactide-
AID445395Cytotoxicity against human MDA-MB-435 cells after 72 hrs by MTT assay2010Journal of medicinal chemistry, Jan-14, Volume: 53, Issue:1
3-arylamino and 3-alkoxy-nor-beta-lapachone derivatives: synthesis and cytotoxicity against cancer cell lines.
AID1867420Antifungal activity against fluconazole resistant Candida glabrata 109 overexpressing CgCdr1p transporter assessed as reduction in fungal growth incubated for 48 hrs in presence of fluconazole by serial dilution method2022Bioorganic & medicinal chemistry, 06-01, Volume: 63Effects of β-lapachone and β-nor-lapachone on multidrug efflux transporters and biofilms of Candida glabrata.
AID1867411Additive antifungal activity against fluconazole resistant Candida glabrata 109 overexpressing CgCdr1p transporter assessed as fractional inhibitory concentration incubated for 48 hrs in presence of fluconazole by checkboard assay based microplate reader 2022Bioorganic & medicinal chemistry, 06-01, Volume: 63Effects of β-lapachone and β-nor-lapachone on multidrug efflux transporters and biofilms of Candida glabrata.
AID1867455Additive antifungal activity against fluconazole resistant Saccharomyces cerevisiae overexpressing CgCdr1p transporter assessed as fractional inhibitory concentration incubated for 48 hrs in presence of lapachone by checkboard assay based microplate reade2022Bioorganic & medicinal chemistry, 06-01, Volume: 63Effects of β-lapachone and β-nor-lapachone on multidrug efflux transporters and biofilms of Candida glabrata.
AID301683Cytotoxicity against human HL60 cells after 72 hrs by MTT assay2007Bioorganic & medicinal chemistry, Nov-15, Volume: 15, Issue:22
Synthesis and potent antitumor activity of new arylamino derivatives of nor-beta-lapachone and nor-alpha-lapachone.
AID744768Cytotoxicity against Swiss mouse peritoneal macrophages after 24 hrs by MTT assay2013European journal of medicinal chemistry, May, Volume: 63Potent naphthoquinones against antimony-sensitive and -resistant Leishmania parasites: synthesis of novel α- and nor-α-lapachone-based 1,2,3-triazoles by copper-catalyzed azide-alkyne cycloaddition.
AID567497Cytotoxicity against human SF295 cells after 72 hrs by MTT assay2011European journal of medicinal chemistry, Jan, Volume: 46, Issue:1
Synthesis and evaluation of quinonoid compounds against tumor cell lines.
AID744766Selectivity index, ratio of CC50 for Swiss mouse peritoneal macrophages to IC50 for antimony-resistant Leishmania infantum MCAN/BR/2002/BH400 promastigote2013European journal of medicinal chemistry, May, Volume: 63Potent naphthoquinones against antimony-sensitive and -resistant Leishmania parasites: synthesis of novel α- and nor-α-lapachone-based 1,2,3-triazoles by copper-catalyzed azide-alkyne cycloaddition.
AID1867422Induction of ROS generation in fluconazole resistant Saccharomyces cerevisiae overexpressing CgCdr2p transporter assessed as fold increase in ROS level incubated for 90 mins by DCFH-DA dye based fluorescence assay2022Bioorganic & medicinal chemistry, 06-01, Volume: 63Effects of β-lapachone and β-nor-lapachone on multidrug efflux transporters and biofilms of Candida glabrata.
AID1416354Induction of morphological changes in human PC3M cells at 11.2 uM after 24 to 72 hrs by hematoxylin/eosin staining-based light microscopic method2017MedChemComm, Oct-01, Volume: 8, Issue:10
Encapsulation of nor-β-lapachone into poly(d,l)-lactide-
AID1416353Cytotoxicity against human DU145 cells assessed as decrease in cell viability using compound loaded PLGA microcapsule after 96 hrs by MTT assay2017MedChemComm, Oct-01, Volume: 8, Issue:10
Encapsulation of nor-β-lapachone into poly(d,l)-lactide-
AID1867405Additive antifungal activity against fluconazole resistant Candida glabrata 109 overexpressing CgCdr1p transporter assessed as reduction in fungal growth incubated for 48 hrs in presence of lapachone by checkboard assay based microplate reader analysis2022Bioorganic & medicinal chemistry, 06-01, Volume: 63Effects of β-lapachone and β-nor-lapachone on multidrug efflux transporters and biofilms of Candida glabrata.
AID567491DNA damage index, DNA damage in human SF295 cells to DNA damage in human HL60 cells with FPG/ENDO3 DNA repair enzymes2011European journal of medicinal chemistry, Jan, Volume: 46, Issue:1
Synthesis and evaluation of quinonoid compounds against tumor cell lines.
AID445394Cytotoxicity against human HL60 cells after 72 hrs by MTT assay2010Journal of medicinal chemistry, Jan-14, Volume: 53, Issue:1
3-arylamino and 3-alkoxy-nor-beta-lapachone derivatives: synthesis and cytotoxicity against cancer cell lines.
AID1441540Substrate activity at recombinant human CPR expressed in baculovirus infected insect cells assessed as compound reduction rate by measuring NADPH consumption per umol of enzyme preincubated for 3 mins followed by NADPH addition measured for 5 mins at 2 se2017European journal of medicinal chemistry, Mar-31, Volume: 129Discovery of quinone-directed antitumor agents selectively bioactivated by NQO1 over CPR with improved safety profile.
AID301687Cytotoxicity against mouse B16 cells after 72 hrs by MTT assay2007Bioorganic & medicinal chemistry, Nov-15, Volume: 15, Issue:22
Synthesis and potent antitumor activity of new arylamino derivatives of nor-beta-lapachone and nor-alpha-lapachone.
AID1867389Disruption of plasma membrane integrity in fluconazole resistant Candida glabrata 109 overexpressing CgCdr1p transporter assessed as increase in sytox green fluorescence intensity at 50 to 200 ug/ml incubated for 48 hrs by fluorescence based assay2022Bioorganic & medicinal chemistry, 06-01, Volume: 63Effects of β-lapachone and β-nor-lapachone on multidrug efflux transporters and biofilms of Candida glabrata.
AID1416333Cytotoxicity against human PC3 cells assessed as decrease in cell viability after 72 hrs by MTT assay2017MedChemComm, Oct-01, Volume: 8, Issue:10
Encapsulation of nor-β-lapachone into poly(d,l)-lactide-
AID744769Antileishmanial activity against antimony-resistant Leishmania amazonensis MHOM/BR/1989/BA199 promastigote infected in Swiss mouse peritoneal macrophages after 72 hrs2013European journal of medicinal chemistry, May, Volume: 63Potent naphthoquinones against antimony-sensitive and -resistant Leishmania parasites: synthesis of novel α- and nor-α-lapachone-based 1,2,3-triazoles by copper-catalyzed azide-alkyne cycloaddition.
AID1185753Cytotoxicity against human KG1 cells after 48 hrs by Alamar blue assay2014European journal of medicinal chemistry, 09-12, Volume: 84Synthesis and evaluation of the cytotoxic activity of 1,2-furanonaphthoquinones tethered to 1,2,3-1H-triazoles in myeloid and lymphoid leukemia cell lines.
AID567492DNA damage index, DNA damage in human SF295 cells to DNA damage in human HL60 cells with FPG/ENDO3 DNA repair enzymes in presence of N-acetylcytosine2011European journal of medicinal chemistry, Jan, Volume: 46, Issue:1
Synthesis and evaluation of quinonoid compounds against tumor cell lines.
AID1867392Antifungal activity against fluconazole resistant Saccharomyces cerevisiae overexpressing CgCdr2p transporter assessed as reduction in fungal growth incubated for 48 hrs by checkboard assay based microplate reader analysis2022Bioorganic & medicinal chemistry, 06-01, Volume: 63Effects of β-lapachone and β-nor-lapachone on multidrug efflux transporters and biofilms of Candida glabrata.
AID1849801Cytotoxicity against human Jurkat cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay2021European journal of medicinal chemistry, Jan-15, Volume: 210A comprehensive review on β-lapachone: Mechanisms, structural modifications, and therapeutic potentials.
AID1867426Effect on efflux pump function in fluconazole resistant Candida glabrata 109 overexpressing CgCdr1p transporter assessed as accumulation of Nile red fluorescence incubated for 1 hr by fluorescence based assay2022Bioorganic & medicinal chemistry, 06-01, Volume: 63Effects of β-lapachone and β-nor-lapachone on multidrug efflux transporters and biofilms of Candida glabrata.
AID301689Cytotoxicity against mouse L929 cells after 72 hrs by MTT assay2007Bioorganic & medicinal chemistry, Nov-15, Volume: 15, Issue:22
Synthesis and potent antitumor activity of new arylamino derivatives of nor-beta-lapachone and nor-alpha-lapachone.
AID301690Toxicity assessed as hemolytic activity against mouse erythrocyte2007Bioorganic & medicinal chemistry, Nov-15, Volume: 15, Issue:22
Synthesis and potent antitumor activity of new arylamino derivatives of nor-beta-lapachone and nor-alpha-lapachone.
AID744771Antileishmanial activity against antimony-resistant Leishmania infantum MCAN/BR/2002/BH400 promastigote infected in Swiss mouse peritoneal macrophages after 72 hrs2013European journal of medicinal chemistry, May, Volume: 63Potent naphthoquinones against antimony-sensitive and -resistant Leishmania parasites: synthesis of novel α- and nor-α-lapachone-based 1,2,3-triazoles by copper-catalyzed azide-alkyne cycloaddition.
AID1867440Induction of morphological changes in fluconazole resistant Candida glabrata 109 overexpressing CgCdr1p transporter assessed as decrease in cell-cell adhesion at 200 ug/ml by calcofluor white dye based confocal laser scanning microscopy2022Bioorganic & medicinal chemistry, 06-01, Volume: 63Effects of β-lapachone and β-nor-lapachone on multidrug efflux transporters and biofilms of Candida glabrata.
AID1867423Induction of ROS generation in fluconazole resistant Candida glabrata 109 overexpressing CgCdr1p assessed as fold increase in ROS level incubated for 90 mins by DCFH-DA dye based fluorescence assay2022Bioorganic & medicinal chemistry, 06-01, Volume: 63Effects of β-lapachone and β-nor-lapachone on multidrug efflux transporters and biofilms of Candida glabrata.
AID1867406Indifferent antifungal activity against fluconazole sensitive Candida glabrata ATCC 2001 assessed as reduction in fungal growth incubated for 48 hrs in presence of lapachone by checkboard assay based microplate reader analysis2022Bioorganic & medicinal chemistry, 06-01, Volume: 63Effects of β-lapachone and β-nor-lapachone on multidrug efflux transporters and biofilms of Candida glabrata.
AID445403Toxicity in mouse erythrocytes assessed as hemolytic activity after 30 mins by spectrophotometry2010Journal of medicinal chemistry, Jan-14, Volume: 53, Issue:1
3-arylamino and 3-alkoxy-nor-beta-lapachone derivatives: synthesis and cytotoxicity against cancer cell lines.
AID1867441Induction of morphological changes in fluconazole resistant Candida glabrata 109 overexpressing CgCdr1p transporter assessed as decrease in cellular density at 200 ug/ml by calcofluor white dye based confocal laser scanning microscopy2022Bioorganic & medicinal chemistry, 06-01, Volume: 63Effects of β-lapachone and β-nor-lapachone on multidrug efflux transporters and biofilms of Candida glabrata.
AID1191936Selectivity ratio of IC50 for human A549 cells in presence of NQO1 inhibitor dicoumarol to IC50 for human A549 cells2015Bioorganic & medicinal chemistry letters, Mar-15, Volume: 25, Issue:6
Synthesis and evaluation of (±)-dunnione and its ortho-quinone analogues as substrates for NAD(P)H:quinone oxidoreductase 1 (NQO1).
AID1597871Cytotoxicity against mouse J774.A1 cells measured after 24 hrs by resazurin based assay
AID567494Cytotoxicity against human HL60 cells after 72 hrs by MTT assay2011European journal of medicinal chemistry, Jan, Volume: 46, Issue:1
Synthesis and evaluation of quinonoid compounds against tumor cell lines.
AID301684Cytotoxicity against human HCT8 cells after 72 hrs by MTT assay2007Bioorganic & medicinal chemistry, Nov-15, Volume: 15, Issue:22
Synthesis and potent antitumor activity of new arylamino derivatives of nor-beta-lapachone and nor-alpha-lapachone.
AID1416330Cytotoxicity against human HCT116 cells assessed as decrease in cell viability after 72 hrs by MTT assay2017MedChemComm, Oct-01, Volume: 8, Issue:10
Encapsulation of nor-β-lapachone into poly(d,l)-lactide-
AID1867409Additive antifungal activity against fluconazole resistant Candida glabrata 109 overexpressing CgCdr1p transporter assessed as reduction in fungal growth incubated for 48 hrs in presence of fluconazole by checkboard assay based microplate reader analysis2022Bioorganic & medicinal chemistry, 06-01, Volume: 63Effects of β-lapachone and β-nor-lapachone on multidrug efflux transporters and biofilms of Candida glabrata.
AID1867464Additive antifungal activity against fluconazole resistant Saccharomyces cerevisiae overexpressing CgCdr1p transporter assessed as fractional inhibitory concentration index incubated for 48 hrs by checkboard assay based microplate reader analysis2022Bioorganic & medicinal chemistry, 06-01, Volume: 63Effects of β-lapachone and β-nor-lapachone on multidrug efflux transporters and biofilms of Candida glabrata.
AID1185757Cytotoxicity against human lymphocytes2014European journal of medicinal chemistry, 09-12, Volume: 84Synthesis and evaluation of the cytotoxic activity of 1,2-furanonaphthoquinones tethered to 1,2,3-1H-triazoles in myeloid and lymphoid leukemia cell lines.
AID1191935Cytotoxicity against human A549 cells after 72 hrs by MTT assay in presence of NQO1 inhibitor dicoumarol2015Bioorganic & medicinal chemistry letters, Mar-15, Volume: 25, Issue:6
Synthesis and evaluation of (±)-dunnione and its ortho-quinone analogues as substrates for NAD(P)H:quinone oxidoreductase 1 (NQO1).
AID567423DNA damage index, DNA damage in human HCT8 cells to DNA damage in human HL60 cells with FPG/ENDO3 DNA repair enzymes2011European journal of medicinal chemistry, Jan, Volume: 46, Issue:1
Synthesis and evaluation of quinonoid compounds against tumor cell lines.
AID481798Antitrypanosomal activity against Trypanosoma cruzi Y blood stream trypomastigotes after 24 hrs2010Bioorganic & medicinal chemistry, May-01, Volume: 18, Issue:9
The evaluation of quinonoid compounds against Trypanosoma cruzi: synthesis of imidazolic anthraquinones, nor-beta-lapachone derivatives and beta-lapachone-based 1,2,3-triazoles.
AID567421DNA damage index, DNA damage in human MDA-MB-435 cells to DNA damage in human HL60 cells with FPG/ENDO3 DNA repair enzymes2011European journal of medicinal chemistry, Jan, Volume: 46, Issue:1
Synthesis and evaluation of quinonoid compounds against tumor cell lines.
AID1441541Selectivity ratio of compound reduction rate catalyzed by recombinant human NQO1 expressed in Escherichia coli to compound reduction rate catalyzed by recombinant human CPR expressed in baculovirus infected insect cells2017European journal of medicinal chemistry, Mar-31, Volume: 129Discovery of quinone-directed antitumor agents selectively bioactivated by NQO1 over CPR with improved safety profile.
AID1867463Synergistic antifungal activity against fluconazole resistant Saccharomyces cerevisiae overexpressing CgCdr2p transporter assessed as fractional inhibitory concentration index incubated for 48 hrs by checkboard assay based microplate reader analysis2022Bioorganic & medicinal chemistry, 06-01, Volume: 63Effects of β-lapachone and β-nor-lapachone on multidrug efflux transporters and biofilms of Candida glabrata.
AID1185752Cytotoxicity against human CCRF-CEM cells after 48 hrs by Alamar blue assay2014European journal of medicinal chemistry, 09-12, Volume: 84Synthesis and evaluation of the cytotoxic activity of 1,2-furanonaphthoquinones tethered to 1,2,3-1H-triazoles in myeloid and lymphoid leukemia cell lines.
AID567502Induction of lipid peroxidation in human HCT8 cells assessed as increase in TBARS formation at 5 uM after 24 hrs in presence of N-acetylcytosine2011European journal of medicinal chemistry, Jan, Volume: 46, Issue:1
Synthesis and evaluation of quinonoid compounds against tumor cell lines.
AID1867416Antifungal activity against fluconazole resistant Saccharomyces cerevisiae overexpressing CgCdr2p transporter assessed as reduction in fungal growth incubated for 48 hrs by serial dilution method2022Bioorganic & medicinal chemistry, 06-01, Volume: 63Effects of β-lapachone and β-nor-lapachone on multidrug efflux transporters and biofilms of Candida glabrata.
AID1867417Antifungal activity against fluconazole resistant Candida glabrata 109 overexpressing CgCdr1p transporter assessed as reduction in fungal growth incubated for 48 hrs by serial dilution method2022Bioorganic & medicinal chemistry, 06-01, Volume: 63Effects of β-lapachone and β-nor-lapachone on multidrug efflux transporters and biofilms of Candida glabrata.
AID1416346Cytotoxicity against human PC3 cells assessed as decrease in cell viability after 24 hrs by MTT assay2017MedChemComm, Oct-01, Volume: 8, Issue:10
Encapsulation of nor-β-lapachone into poly(d,l)-lactide-
AID1185751Cytotoxicity against human MOLT4 cells after 48 hrs by Alamar blue assay2014European journal of medicinal chemistry, 09-12, Volume: 84Synthesis and evaluation of the cytotoxic activity of 1,2-furanonaphthoquinones tethered to 1,2,3-1H-triazoles in myeloid and lymphoid leukemia cell lines.
AID1867388Antibiofilm activity against fluconazole resistant Candida glabrata 109 overexpressing CgCdr1p transporter assessed as reduction in metabolic activity at highest concentration incubated for 48 hrs2022Bioorganic & medicinal chemistry, 06-01, Volume: 63Effects of β-lapachone and β-nor-lapachone on multidrug efflux transporters and biofilms of Candida glabrata.
AID1185754Cytotoxicity against human K562 cells after 48 hrs by Alamar blue assay2014European journal of medicinal chemistry, 09-12, Volume: 84Synthesis and evaluation of the cytotoxic activity of 1,2-furanonaphthoquinones tethered to 1,2,3-1H-triazoles in myeloid and lymphoid leukemia cell lines.
AID744765Selectivity index, ratio of CC50 for Swiss mouse peritoneal macrophages to IC50 for antimony-sensitive Leishmania amazonensis MHOM/BR/1989/BA199 promastigote2013European journal of medicinal chemistry, May, Volume: 63Potent naphthoquinones against antimony-sensitive and -resistant Leishmania parasites: synthesis of novel α- and nor-α-lapachone-based 1,2,3-triazoles by copper-catalyzed azide-alkyne cycloaddition.
AID1867413Additive antifungal activity against fluconazole resistant Candida glabrata 109 overexpressing CgCdr1p transporter assessed as fractional inhibitory concentration index incubated for 48 hrs by checkboard assay based microplate reader analysis2022Bioorganic & medicinal chemistry, 06-01, Volume: 63Effects of β-lapachone and β-nor-lapachone on multidrug efflux transporters and biofilms of Candida glabrata.
AID1849800Cytotoxicity against human HCT-8 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay2021European journal of medicinal chemistry, Jan-15, Volume: 210A comprehensive review on β-lapachone: Mechanisms, structural modifications, and therapeutic potentials.
AID1416338Cytotoxicity against human DU145 cells assessed as decrease in cell viability using compound loaded PLGA microcapsule after 72 hrs by MTT assay2017MedChemComm, Oct-01, Volume: 8, Issue:10
Encapsulation of nor-β-lapachone into poly(d,l)-lactide-
AID1416343Cytotoxicity against human PC3M cells assessed as decrease in cell viability using compound loaded PLGA microcapsule after 24 hrs by MTT assay2017MedChemComm, Oct-01, Volume: 8, Issue:10
Encapsulation of nor-β-lapachone into poly(d,l)-lactide-
AID1867418Antifungal activity against fluconazole resistant Saccharomyces cerevisiae overexpressing CgCdr1p transporter assessed as reduction in fungal growth incubated for 48 hrs in presence of fluconazole by serial dilution method2022Bioorganic & medicinal chemistry, 06-01, Volume: 63Effects of β-lapachone and β-nor-lapachone on multidrug efflux transporters and biofilms of Candida glabrata.
AID1416339Cytotoxicity against human PC3M cells assessed as decrease in cell viability using compound loaded PLGA microcapsule after 72 hrs by MTT assay2017MedChemComm, Oct-01, Volume: 8, Issue:10
Encapsulation of nor-β-lapachone into poly(d,l)-lactide-
AID1416352Cytotoxicity against human DU145 cells assessed as decrease in cell viability after 96 hrs by MTT assay2017MedChemComm, Oct-01, Volume: 8, Issue:10
Encapsulation of nor-β-lapachone into poly(d,l)-lactide-
AID1867439Induction of morphological changes in fluconazole resistant Candida glabrata 109 overexpressing CgCdr1p transporter assessed as decrease in biofilm thickness at 200 ug/ml by calcofluor white dye based confocal laser scanning microscopy2022Bioorganic & medicinal chemistry, 06-01, Volume: 63Effects of β-lapachone and β-nor-lapachone on multidrug efflux transporters and biofilms of Candida glabrata.
AID1867434Inhibition of fluconazole resistant Candida glabrata 109 overexpressing CgCdr1p transporter bacterial cell adhesion to polystyrene at 200 ug/ml incubated for 90 mins by MTT assay2022Bioorganic & medicinal chemistry, 06-01, Volume: 63Effects of β-lapachone and β-nor-lapachone on multidrug efflux transporters and biofilms of Candida glabrata.
AID301686Cytotoxicity against human SF295 cells after 72 hrs by MTT assay2007Bioorganic & medicinal chemistry, Nov-15, Volume: 15, Issue:22
Synthesis and potent antitumor activity of new arylamino derivatives of nor-beta-lapachone and nor-alpha-lapachone.
AID567495Cytotoxicity against human MDA-MB-435 cells after 72 hrs by MTT assay2011European journal of medicinal chemistry, Jan, Volume: 46, Issue:1
Synthesis and evaluation of quinonoid compounds against tumor cell lines.
AID744772Antileishmanial activity against antimony-sensitive Leishmania infantum MCAN/BR/2002/BH400 promastigote infected in Swiss mouse peritoneal macrophages after 72 hrs2013European journal of medicinal chemistry, May, Volume: 63Potent naphthoquinones against antimony-sensitive and -resistant Leishmania parasites: synthesis of novel α- and nor-α-lapachone-based 1,2,3-triazoles by copper-catalyzed azide-alkyne cycloaddition.
AID567411Induction of lipid peroxidation in human MDA-MB-435 cells assessed as increase in TBARS formation at 5 uM after 24 hrs2011European journal of medicinal chemistry, Jan, Volume: 46, Issue:1
Synthesis and evaluation of quinonoid compounds against tumor cell lines.
AID1867452Additive antifungal activity against fluconazole resistant Saccharomyces cerevisiae overexpressing CgCdr1p transporter assessed as reduction in fungal growth incubated for 48 hrs in presence of lapachone by checkboard assay based microplate reader analysi2022Bioorganic & medicinal chemistry, 06-01, Volume: 63Effects of β-lapachone and β-nor-lapachone on multidrug efflux transporters and biofilms of Candida glabrata.
AID1867437Antibiofilm activity against fluconazole sensitive Candida glabrata ATCC 2001 assessed as inhibition of biofilm formation at 200 ug/ml incubated for 48 hrs2022Bioorganic & medicinal chemistry, 06-01, Volume: 63Effects of β-lapachone and β-nor-lapachone on multidrug efflux transporters and biofilms of Candida glabrata.
AID1867419Antifungal activity against fluconazole resistant Saccharomyces cerevisiae overexpressing CgCdr2p transporter assessed as reduction in fungal growth incubated for 48 hrs in presence of fluconazole by serial dilution method2022Bioorganic & medicinal chemistry, 06-01, Volume: 63Effects of β-lapachone and β-nor-lapachone on multidrug efflux transporters and biofilms of Candida glabrata.
AID1185758Cytotoxicity against Chinese hamster V79 cells2014European journal of medicinal chemistry, 09-12, Volume: 84Synthesis and evaluation of the cytotoxic activity of 1,2-furanonaphthoquinones tethered to 1,2,3-1H-triazoles in myeloid and lymphoid leukemia cell lines.
AID1416348Cytotoxicity against human DU145 cells assessed as decrease in cell viability after 24 hrs by MTT assay2017MedChemComm, Oct-01, Volume: 8, Issue:10
Encapsulation of nor-β-lapachone into poly(d,l)-lactide-
AID744764Selectivity index, ratio of CC50 for Swiss mouse peritoneal macrophages to IC50 for antimony-resistant Leishmania amazonensis MHOM/BR/1989/BA199 promastigote2013European journal of medicinal chemistry, May, Volume: 63Potent naphthoquinones against antimony-sensitive and -resistant Leishmania parasites: synthesis of novel α- and nor-α-lapachone-based 1,2,3-triazoles by copper-catalyzed azide-alkyne cycloaddition.
AID1185755Cytotoxicity against normal human PBMC assessed as reduction in cell viability at 10 times anti-leukemic IC50 after 48 hrs by Alamar blue assay2014European journal of medicinal chemistry, 09-12, Volume: 84Synthesis and evaluation of the cytotoxic activity of 1,2-furanonaphthoquinones tethered to 1,2,3-1H-triazoles in myeloid and lymphoid leukemia cell lines.
AID1867425Effect on efflux pump function in fluconazole resistant Saccharomyces cerevisiae overexpressing CgCdr2p transporter assessed as accumulation of Nile red fluorescence incubated for 1 hr by fluorescence based assay2022Bioorganic & medicinal chemistry, 06-01, Volume: 63Effects of β-lapachone and β-nor-lapachone on multidrug efflux transporters and biofilms of Candida glabrata.
AID744770Antileishmanial activity against antimony-sensitive Leishmania amazonensis MHOM/BR/1989/BA199 promastigote infected in Swiss mouse peritoneal macrophages after 72 hrs2013European journal of medicinal chemistry, May, Volume: 63Potent naphthoquinones against antimony-sensitive and -resistant Leishmania parasites: synthesis of novel α- and nor-α-lapachone-based 1,2,3-triazoles by copper-catalyzed azide-alkyne cycloaddition.
AID1191934Cytotoxicity against human A549 cells after 72 hrs by MTT assay2015Bioorganic & medicinal chemistry letters, Mar-15, Volume: 25, Issue:6
Synthesis and evaluation of (±)-dunnione and its ortho-quinone analogues as substrates for NAD(P)H:quinone oxidoreductase 1 (NQO1).
AID1867442Induction of morphological changes in fluconazole resistant Candida glabrata 109 overexpressing CgCdr1p transporter assessed as decrease in number of cells within biofilm at 200 ug/ml incubated for 48 hrs by SEM analysis2022Bioorganic & medicinal chemistry, 06-01, Volume: 63Effects of β-lapachone and β-nor-lapachone on multidrug efflux transporters and biofilms of Candida glabrata.
AID567501Induction of lipid peroxidation in human MDA-MB-435 cells assessed as increase in TBARS formation at 5 uM after 24 hrs in presence of N-acetylcytosine2011European journal of medicinal chemistry, Jan, Volume: 46, Issue:1
Synthesis and evaluation of quinonoid compounds against tumor cell lines.
AID1849799Cytotoxicity against human MDA-MB-435 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay2021European journal of medicinal chemistry, Jan-15, Volume: 210A comprehensive review on β-lapachone: Mechanisms, structural modifications, and therapeutic potentials.
AID1416342Cytotoxicity against human PC3M cells assessed as decrease in cell viability after 24 hrs by MTT assay2017MedChemComm, Oct-01, Volume: 8, Issue:10
Encapsulation of nor-β-lapachone into poly(d,l)-lactide-
AID1597873Antimycobacterial activity against isoniazid resistant Mycobacterium tuberculosis H37Rv ATCC 27294 measured after 7 days by resazurin microtiter assay
AID1416355Induction of morphological changes in human PC3M cells at 5.4 uM using compound loaded PLGA microcapsule after 24 to 72 hrs by hematoxylin/eosin staining-based light microscopic method2017MedChemComm, Oct-01, Volume: 8, Issue:10
Encapsulation of nor-β-lapachone into poly(d,l)-lactide-
AID1867384Indifferent antifungal activity against fluconazole resistant Candida glabrata 109 overexpressing CgCdr1p transporter assessed as reduction in fungal growth incubated for 48 hrs in presence of lapachone by checkboard assay based microplate reader analysis2022Bioorganic & medicinal chemistry, 06-01, Volume: 63Effects of β-lapachone and β-nor-lapachone on multidrug efflux transporters and biofilms of Candida glabrata.
AID1867415Antifungal activity against fluconazole resistant Saccharomyces cerevisiae overexpressing CgCdr1p transporter assessed as reduction in fungal growth at lower concentration incubated for 48 hrs by serial dilution method2022Bioorganic & medicinal chemistry, 06-01, Volume: 63Effects of β-lapachone and β-nor-lapachone on multidrug efflux transporters and biofilms of Candida glabrata.
AID1867429Inhibition of fluconazole resistant Candida glabrata 109 overexpressing CgCdr1p transporter ATPase activity assessed as reduction in inorganic phosphate release in presence of ATP incubated for 1 hr by Fiske and Sub barrow method2022Bioorganic & medicinal chemistry, 06-01, Volume: 63Effects of β-lapachone and β-nor-lapachone on multidrug efflux transporters and biofilms of Candida glabrata.
AID1867391Antifungal activity against fluconazole resistant Saccharomyces cerevisiae overexpressing CgCdr1p transporter assessed as reduction in fungal growth incubated for 48 hrs by checkboard assay based microplate reader analysis2022Bioorganic & medicinal chemistry, 06-01, Volume: 63Effects of β-lapachone and β-nor-lapachone on multidrug efflux transporters and biofilms of Candida glabrata.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (20)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (5.00)29.6817
2010's15 (75.00)24.3611
2020's4 (20.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.08

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.08 (24.57)
Research Supply Index3.04 (2.92)
Research Growth Index5.12 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.08)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (5.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other19 (95.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
lactic acid
Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed). 2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.		2.13102-hydroxy monocarboxylic acidalgal metabolite;
Daphnia magna metabolite
fluconazole
Fluconazole: Triazole antifungal agent that is used to treat oropharyngeal CANDIDIASIS and cryptococcal MENINGITIS in AIDS.. fluconazole : A member of the class of triazoles that is propan-2-ol substituted at position 1 and 3 by 1H-1,2,4-triazol-1-yl groups and at position 2 by a 2,4-difluorophenyl group. It is an antifungal drug used for the treatment of mucosal candidiasis and for systemic infections including systemic candidiasis, coccidioidomycosis, and cryptococcosis.		2.4110conazole antifungal drug;
difluorobenzene;
tertiary alcohol;
triazole antifungal drug		environmental contaminant;
P450 inhibitor;
xenobiotic
itraconazole
[no description available]		3.4110piperazines
lapachol
lapachol : A hydroxy-1,4-naphthoquinone that is 1,4-naphthoquinone substituted by hydroxy and 3-methylbut-2-en-1-yl groups at positions 2 and 3, respectively. It is a natural compound that exhibits antibacterial and anticancer properties, first isolated in 1882 from the bark of Tabebuia avellanedae.		2.9940
beta-lapachone
beta-lapachone: antineoplastic inhibitor of reverse transcriptase, DNA topoisomerase, and DNA polymerase. beta-lapachone : A benzochromenone that is 3,4-dihydro-2H-benzo[h]chromene-5,6-dione substituted by geminal methyl groups at position 2. Isolated from Tabebuia avellanedae, it exhibits antineoplastic and anti-inflammatory activities.		4.98110benzochromenone;
orthoquinones		anti-inflammatory agent;
antineoplastic agent;
plant metabolite
vitamin k 3
Vitamin K 3: A synthetic naphthoquinone without the isoprenoid side chain and biological activity, but can be converted to active vitamin K2, menaquinone, after alkylation in vivo.		2.11101,4-naphthoquinones;
vitamin K		angiogenesis inhibitor;
antineoplastic agent;
EC 3.4.22.69 (SARS coronavirus main proteinase) inhibitor;
human urinary metabolite;
nutraceutical
quinone
benzoquinone : The simplest members of the class of benzoquinones, consisting of cyclohexadiene which is substituted by two oxo groups.. 1,4-benzoquinone : The simplest member of the class of 1,4-benzoquinones, obtained by the formal oxidation of hydroquinone to the corresponding diketone. It is a metabolite of benzene.. quinone : Compounds having a fully conjugated cyclic dione structure, such as that of benzoquinones, derived from aromatic compounds by conversion of an even number of -CH= groups into -C(=O)- groups with any necessary rearrangement of double bonds (polycyclic and heterocyclic analogues are included).		2.1101,4-benzoquinonescofactor;
human xenobiotic metabolite;
mouse metabolite
chloramphenicol
Amphenicol: Chloramphenicol and its derivatives.		3.4110C-nitro compound;
carboxamide;
diol;
organochlorine compound		antibacterial drug;
antimicrobial agent;
Escherichia coli metabolite;
geroprotector;
Mycoplasma genitalium metabolite;
protein synthesis inhibitor
lawsone
lawsone: a molluscacide from leaves of Lawsonia inermis L. topical sunscreening agent; structure; powdered leaves of Lawsonia inermis(Lythraceae) used as brown hair dye. lawsone : 1,4-Naphthoquinone carrying a hydroxy function at C-2. It is obtained from the leaves of Lawsonia inermis.		2.0710
benzotriazole
benzotriazole: inhibitor of atmospheric metal corrosion; also component of motion picture film & Neva brake fluid. benzotriazole : The simplest member of the class of benzotriazoles that consists of a benzene nucleus fused to a 1H-1,2,3-triazole ring.		2.3110benzotriazolesenvironmental contaminant;
xenobiotic
dichlone
dichlone: structure		2.0710
gentian violet
Gentian Violet: A dye that is a mixture of violet rosanilinis with antibacterial, antifungal, and anthelmintic properties.. crystal violet : An organic chloride salt that is the monochloride salt of crystal violet cation. It has been used in creams for the topical treatment of bacterial and fungal infections, being effective against some Gram-positive bacteria (notably Staphylococcus species) and some pathogenic fungi (including Candida species) but use declined following reports of animal carcinogenicity. It has also been used for dying wood, silk, and paper, as well as a histological stain.		2.0710organic chloride saltanthelminthic drug;
antibacterial agent;
antifungal agent;
antiseptic drug;
histological dye
2-chloro-1,4-naphthoquinone
2-chloro-1,4-naphthoquinone: Vitamin K dependent carboxylase antagonist		2.07101,4-naphthoquinones;
organochlorine compound
benzonidazole
benzonidazole: used in treatment of Chagas' disease. benznidazole : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of (2-nitroimidazol-1-yl)acetic acid with the aromatic amino group of benzylamine. Used for treatment of Chagas disease.		3.6420C-nitro compound;
imidazoles;
monocarboxylic acid amide		antiprotozoal drug
triazoles
Triazoles: Heterocyclic compounds containing a five-membered ring with two carbon atoms and three nitrogen atoms with the molecular formula C2H3N3.. triazoles : An azole in which the five-membered heterocyclic aromatic skeleton contains three N atoms and two C atoms.		2.31101,2,3-triazole
alpha-lapachone
alpha-lapachone: structure in first source		3.0540organic heterotricyclic compound;
organooxygen compound
xyloidone
[no description available]		2.1510
2-bromo-1,4-naphthoquinone
2-bromo-1,4-naphthoquinone: structure in first source		2.0710
hydrolapachol
hydrolapachol: inhibits mitochondrial respiratory chain		2.0610
rhinacanthone
rhinacanthone: structure in first source		3.4110
norlapachol
norlapachol: structure in first source		2.4720
benzofurans
Benzofurans: Compounds that contain a BENZENE ring fused to a furan ring.		3.2250
dunnione
dunnione: RN given for (+)-isomer; an industrial fungicide; structure in first source		2.5320naphthofuran
doxorubicin hydrochloride
[no description available]		2.110anthracycline
naphthoquinones
Naphthoquinones: Naphthalene rings which contain two ketone moieties in any position. They can be substituted in any position except at the ketone groups.		3.2250
ascorbic acid
Ascorbic Acid: A six carbon compound related to glucose. It is found naturally in citrus fruits and many vegetables. Ascorbic acid is an essential nutrient in human diets, and necessary to maintain connective tissue and bone. Its biologically active form, vitamin C, functions as a reducing agent and coenzyme in several metabolic pathways. Vitamin C is considered an antioxidant.. L-ascorbic acid : The L-enantiomer of ascorbic acid and conjugate acid of L-ascorbate.. L-ascorbate : The L-enantiomer of ascorbate and conjugate base of L-ascorbic acid, arising from selective deprotonation of the 3-hydroxy group. Required for a range of essential metabolic reactions in all animals and plants.. vitamin C : Any member of a group of vitamers that belong to the chemical structural class called butenolides that exhibit biological activity against vitamin C deficiency in animals. The vitamers include L-ascorbic acid and its salt, ionized and oxidized forms.		2.4110ascorbic acid;
vitamin C		coenzyme;
cofactor;
flour treatment agent;
food antioxidant;
food colour retention agent;
geroprotector;
plant metabolite;
skin lightening agent
ConditionIndicatedRelationship StrengthStudiesTrials
Cancer of Esophagus
[description not available]		02.0810
Esophageal Neoplasms
Tumors or cancer of the ESOPHAGUS.		02.0810
Leukemia, Lymphocytic
[description not available]		02.110
Granulocytic Leukemia
[description not available]		02.110
Leukemia, Lymphoid
Leukemia associated with HYPERPLASIA of the lymphoid tissues and increased numbers of circulating malignant LYMPHOCYTES and lymphoblasts.		02.110
Leukemia, Myeloid
Form of leukemia characterized by an uncontrolled proliferation of the myeloid lineage and their precursors (MYELOID PROGENITOR CELLS) in the bone marrow and other sites.		02.110
Benign Neoplasms
[description not available]		03.2310
Neoplasms
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.		03.2310
Experimental Hepatoma
[description not available]		02.3110
American Trypanosomiasis
[description not available]		02.1110
Chagas Disease
Infection with the protozoan parasite TRYPANOSOMA CRUZI, a form of TRYPANOSOMIASIS endemic in Central and South America. It is named after the Brazilian physician Carlos Chagas, who discovered the parasite. Infection by the parasite (positive serologic result only) is distinguished from the clinical manifestations that develop years later, such as destruction of PARASYMPATHETIC GANGLIA; CHAGAS CARDIOMYOPATHY; and dysfunction of the ESOPHAGUS or COLON.		02.1110
Cancer of Prostate
[description not available]		02.1310
Prostatic Neoplasms
Tumors or cancer of the PROSTATE.		02.1310