Any intra-glandular substance that acts as a precursor of a hormone, usually having minimal hormonal effect itself. Prohormones generally help in amplifying the effect of existing hormones.
ChEBI ID: 71212
| Member | Definition | Class |
|---|---|---|
| 7-oxodehydroepiandrosterone | A 3beta-hydroxy-Delta(5)-steroid that is dehydroepiandrosterone carrying an additional oxo group at position 7. | 7-ketodehydroepiandrosterone |
| ecdysone | A 6-oxo steroid that is 5beta-cholest-7-en-6-one substituted by hydroxy groups at positions 2, 3, 14, 22 and 25 respectively (the 2beta, 3beta, 22R stereoisomer). It is a steroid prohormone of the major insect moulting hormone 20-hydroxyecdysone. | ecdysone |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 783 (41.06) | 18.7374 |
| 1990's | 233 (12.22) | 18.2507 |
| 2000's | 349 (18.30) | 29.6817 |
| 2010's | 378 (19.82) | 24.3611 |
| 2020's | 164 (8.60) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 3 (0.15%) | 5.53% |
| Reviews | 161 (8.19%) | 6.00% |
| Case Studies | 1 (0.05%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 1,802 (91.61%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 20-hydroxy-ecdysone receptor | Nezara viridula (southern green stink bug) | IC50 | 60.0000 | 2 | 2 |
| 20-hydroxy-ecdysone receptor | Nezara viridula (southern green stink bug) | Ki | 50.7500 | 2 | 2 |
| Ecdysone receptor | Drosophila melanogaster (fruit fly) | IC50 | 2.5704 | 1 | 1 |
| Ultraspiracle | Nezara viridula (southern green stink bug) | IC50 | 60.0000 | 2 | 2 |
| Ultraspiracle | Nezara viridula (southern green stink bug) | Ki | 50.7500 | 2 | 2 |