Cefepime: A fourth-generation cephalosporin antibacterial agent that is used in the treatment of infections, including those of the abdomen, urinary tract, respiratory tract, and skin. It is effective against PSEUDOMONAS AERUGINOSA and may also be used in the empiric treatment of FEBRILE NEUTROPENIA. [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
cefepime : A cephalosporin bearing (1-methylpyrrolidinium-1-yl)methyl and (2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetamido groups at positions 3 and 7, respectively, of the cephem skeleton. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]
| ID Source | ID |
|---|---|
| PubMed CID | 5479537 |
| CHEMBL ID | 186 |
| CHEBI ID | 478164 |
| SCHEMBL ID | 65720 |
| MeSH ID | M0127410 |
| Synonym |
|---|
| AB01275446-01 |
| bmy-28142 |
| maxipime |
| C08111 |
| cefepime |
| (6r,7r)-7-{[(2z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino}-3-[(1-methylpyrrolidinium-1-yl)methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate |
| DB01413 |
| cefepime (usan/inn) |
| cfpm |
| D02376 |
| cefepimum [latin] |
| cefepima [spanish] |
| pyrrolidinium, 1-((7-(((2-amino-4-thiazolyl)(methoxyimino)acetyl)amino)-2-carboxy-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-en-3-yl)methyl)-1-methyl-, hydroxide, inner salt, (6r-(6alpha,7beta(z)))- |
| bmy 28142 |
| 1-(((6r,7r)-7-(2-(2-amino-4-thiazolyl)glyoxylamido)-2-carboxy-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-en-3-yl)methyl)-1-methylpyrrolidinium hydroxide, inner salt, 7(sup 2)-(z)-(o-methyloxime) |
| HMS2089M18 |
| vnrx-5022 |
| j01de01 |
| CHEMBL186 |
| cefepim |
| (6r,7r)-7-[[(2z)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-3-[(1-methylpyrrolidin-1-ium-1-yl)methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate |
| cefepima |
| cefepimum |
| chebi:478164 , |
| 7beta-[(2z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetamido]-3-[(1-methylpyrrolidinium-1-yl)methyl]-3,4-didehydrocepham-4-carboxylate |
| C-2468 |
| BCP9000504 |
| bdbm50350470 |
| AKOS016014147 |
| unii-807pw4vqe3 |
| 807pw4vqe3 , |
| cefepime [usan:inn:ban] |
| BCPP000292 |
| AKOS015850865 |
| cefepime [usan] |
| cefepime [who-dd] |
| cefepime [vandf] |
| pyrrolidinium, 1-((7-(((2-amino-4-thiazolyl)(methoxyimino)acetyl)amino)-2-carboxy-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-en-3-yl)methyl)-1-methyl-, hydroxide, inner salt, (6r-(6.alpha.,7.beta.(z)))- |
| cefepime [mi] |
| cefepime [inn] |
| SCHEMBL65720 |
| 1-{[(6r,7r)-7-[(2z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetamido]-2-carboxylato-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl}-1-methylpyrrolidin-1-ium |
| DTXSID70873208 , |
| Q27294816 |
| HY-B0692 |
| CS-0009590 |
| AS-76125 |
| j01da24 |
| (6r,7r)-7-(((2z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl)amino)-3-((1-methylpyrrolidinium-1-yl)methyl)-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylate |
| cefepimum (latin) |
| dtxcid20820707 |
| 7beta-((2z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetamido)-3-((1-methylpyrrolidinium-1-yl)methyl)-3,4-didehydrocepham-4-carboxylate |
Cefepime is a widely used antibiotic which was known to have neurotoxicity resulted from its ability to cross the blood-brain barrier and a wide variety of symptoms had been documented. It is a first-line therapy for Gram-negative infections in children on extracorporeal membrane oxygenation.
Cefepime has a similar efficacy as carbapenems for the treatment of Enterobacter species bacteremia. It has a linear pharmacokinetic profile, an elimination half-life of approximately 2 hours and is primarily excreted by renal mechanisms as unchanged drug.
Cefepime has a linear pharmacokinetic profile, an elimination half-life of approximately 2 hours and is primarily excreted by renal mechanisms as unchanged drug. It has good activity against gram-positive organisms, such as Staphylococcus aureus, and gram-negative organisms, like Pseudomonas aeruginosa.
| Excerpt | Reference | Relevance |
|---|---|---|
| "Cefepime has a similar efficacy as carbapenems for the treatment of Enterobacter species bacteremia. " | ( Cefepime vs other antibacterial agents for the treatment of Enterobacter species bacteremia. Baghdady, N; Ferraro, MJ; Galar, A; Guzmán-Suarez, BB; Hooper, DC; Kubiak, DW; Marty, FM; O'Brien, TF; Siedner, MJ, 2014) | 3.29 |
| "Cefepime (Maxipime) has a very large spectrum, including the majority of the microorganisms implicated in surgical infections: Enterobacter, Klebsiella pneumoniae/speciae, Proteus mirabilis, Bacillus fragillis, Pseudomonas aeruginosa, Serratia, Citrobacter and other Gram-negative bacilii, Gram-positive cocci (Staphylococcus aureus, Streptococcus pneumoniae, Streptococcus pyogenes)." | ( [Cefepime (Maxipime) treatment efficacy in surgical patients ]. Bratucu, E; Simion, L; Straja, D; Văluţă, I, ) | 1.76 |
| "Cefepime has a greater propensity to select multiresistant Gram-negative pathogens than piperacillin/tazobactam and should not be used extensively in neonatal intensive care." | ( Cefepime restriction improves gram-negative overall resistance patterns in neonatal intensive care unit. Afonso, MR; Albertoni, Ade C; Arkader, R; Cabral, EA; da Silva, DC; de Araujo, OR; Diegues, AR; Louzada, ME, 2007) | 2.5 |
| "Cefepime has a linear pharmacokinetic profile, an elimination half-life of approximately 2 hours and is primarily excreted by renal mechanisms as unchanged drug." | ( Cefepime. A review of its antibacterial activity, pharmacokinetic properties and therapeutic use. Barradell, LB; Bryson, HM, 1994) | 2.45 |
| "Cefepime has a good toxicity profile, with minor gastrointestinal and central nervous system symptoms being most prevalent." | ( Cefepime. Hardin, TC; Jennings, TS, ) | 2.3 |
| "Cefepime has a high affinity for penicillin-binding proteins and, due to its zwitterionic configuration, rapidly penetrates outer-membrane porin channels of bacteria." | ( Cefepime: a fourth-generation parenteral cephalosporin. Paladino, JA; Wynd, MA, 1996) | 2.46 |
| "Cefepime has a spectrum of activity almost as broad as that of the carbapenems." | ( Multicentre study of the in vitro activity of cefepime, a broad-spectrum cephalosporin, compared to other broad-spectrum agents. Bell, JM; Turnidge, JD, 2001) | 1.29 |
| "EI cefepime has been associated with decreased mortality and shorter ICU LOS in patients with Pseudomonas aeruginosa infections." | ( Evaluation of studies on extended versus standard infusion of beta-lactam antibiotics. Buurma, V; Chen, M; Fahim, G; Shah, M, 2019) | 1.03 |
| "Cefepime has not been widely studied in combination with BLIs." | ( Cefepime/sulbactam as an enhanced antimicrobial combination therapy for the treatment of MDR Gram-negative infections. Hornsey, M; Momin, MHFA; Phee, LM; Standing, JF; Wareham, DW, 2020) | 2.72 |
| "Cefepime has been shown to be non-inferior to carbapenems." | ( Clinical outcomes following treatment of Enterobacter species pneumonia with piperacillin/tazobactam compared to cefepime or ertapenem. Bazan, JA; Coe, KE; Elefritz, JL; Fussner, LA; Holsen, MR; Wardlow, LC, 2019) | 1.45 |
| "Cefepime has a similar efficacy as carbapenems for the treatment of Enterobacter species bacteremia. " | ( Cefepime vs other antibacterial agents for the treatment of Enterobacter species bacteremia. Baghdady, N; Ferraro, MJ; Galar, A; Guzmán-Suarez, BB; Hooper, DC; Kubiak, DW; Marty, FM; O'Brien, TF; Siedner, MJ, 2014) | 3.29 |
| "Cefepime neurotoxicity has been reported primarily among patients with renal insufficiency who received standard doses of the antibiotic." | ( Dosing Cefepime for Renal Function Does Not Completely Prevent Neurotoxicity in a Patient With Kidney Transplant. Balderia, PG; Chandorkar, A; Kim, Y; Newman, GC; Patnaik, S; Sloan, J, 2018) | 1.66 |
| "Cefepime has been associated with a greater risk of mortality than other beta-lactams in patients treated for severe sepsis. " | ( Prospective monitoring of cefepime in intensive care unit adult patients. Berger, MM; Bolay, S; Bugnon, D; Chapuis, TM; Chioléro, R; Décosterd, LA; Giannoni, E; Majcherczyk, PA; Moreillon, P; Schaller, MD, 2010) | 2.1 |
| "Cefepime has activity against many hospital-acquired Gram-negative pathogens resistant to earlier beta-lactam antibiotics. " | ( Cefepime use in a pediatric intensive care unit reduces colonization with resistant bacilli. Blumer, JL; Dul, M; O'Riordan, MA; Rosolowski, B; Salvator, A; Toltzis, H; Toltzis, P, 2003) | 3.2 |
| "Cefepime has been examined for stability, potential liberation of degradation products and compatibility with other drugs under conditions mimicking its potential use by continuous infusion in cystic fibrosis and intensive care patients (5-12% w/v solutions; temperatures from 20 to 37 degrees C; 1 h contact at 25 degrees C with other drugs frequently co-administered by intravenous route to these types of patients). " | ( Stability and compatibility study of cefepime in comparison with ceftazidime for potential administration by continuous infusion under conditions pertinent to ambulatory treatment of cystic fibrosis patients and to administration in intensive care units. Baririan, N; Chanteux, H; Servais, H; Tulkens, PM; Viaene, E, 2003) | 2.03 |
| "Cefepime (Maxipime) has a very large spectrum, including the majority of the microorganisms implicated in surgical infections: Enterobacter, Klebsiella pneumoniae/speciae, Proteus mirabilis, Bacillus fragillis, Pseudomonas aeruginosa, Serratia, Citrobacter and other Gram-negative bacilii, Gram-positive cocci (Staphylococcus aureus, Streptococcus pneumoniae, Streptococcus pyogenes)." | ( [Cefepime (Maxipime) treatment efficacy in surgical patients ]. Bratucu, E; Simion, L; Straja, D; Văluţă, I, ) | 1.76 |
| "Cefepime has in vitro activity against Gram-positive organisms including Staphylococcus aureus and penicillin-sensitive, -intermediate and -resistant Streptococcus pneumoniae similar to that of cefotaxime and ceftriaxone." | ( Cefepime: a review of its use in the management of hospitalized patients with pneumonia. Chapman, TM; Perry, CM, 2003) | 2.48 |
| "Cefepime has broad-spectrum activity against gram-negative and gram-positive organisms." | ( Pharmacodynamics of cefepime alone and in combination with various antimicrobials against methicillin-resistant Staphylococcus aureus in an in vitro pharmacodynamic infection model. Huang, V; Rybak, MJ, 2005) | 1.37 |
| "Cefepime has the required pharmacokinetic properties to be considered for pre-operative antimicrobial prophylaxis in patients undergoing biliary tract surgery." | ( Pharmacokinetics of cefepime in bile and gall bladder tissue after prophylactic administration in patients with extrahepatic biliary diseases. Antonios, P; Bastounis, E; Daikos, GL; Kastanakis, M; Kastanakis, S; Katsilambros, N; Markogiannakis, A; Petrikkos, G, 2006) | 1.38 |
| "Cefepime has a greater propensity to select multiresistant Gram-negative pathogens than piperacillin/tazobactam and should not be used extensively in neonatal intensive care." | ( Cefepime restriction improves gram-negative overall resistance patterns in neonatal intensive care unit. Afonso, MR; Albertoni, Ade C; Arkader, R; Cabral, EA; da Silva, DC; de Araujo, OR; Diegues, AR; Louzada, ME, 2007) | 2.5 |
| "Cefepime has a linear pharmacokinetic profile, an elimination half-life of approximately 2 hours and is primarily excreted by renal mechanisms as unchanged drug." | ( Cefepime. A review of its antibacterial activity, pharmacokinetic properties and therapeutic use. Barradell, LB; Bryson, HM, 1994) | 2.45 |
| "Cefepime has a good toxicity profile, with minor gastrointestinal and central nervous system symptoms being most prevalent." | ( Cefepime. Hardin, TC; Jennings, TS, ) | 2.3 |
| "Cefepime has good activity against gram-positive organisms, such as Staphylococcus aureus, and gram-negative organisms, such as Pseudomonas aeruginosa." | ( Cefepime: a new fourth-generation cephalosporin. Bedikian, A; Chin, A; Gill, MA; Nakahiro, RK; Okamoto, MP, 1994) | 2.45 |
| "Cefepime has in vitro activity against many bacterial isolates resistant to ceftazidime and cefotaxime, is stable against chromosomally mediated beta-lactamases, demonstrates lower affinity for these enzymes and shows a high resistance to enzymatic hydrolysis." | ( Cefepime clinical pharmacokinetics. Bedikian, A; Chin, A; Nakahiro, RK; Okamoto, MP, 1993) | 2.45 |
| "Cefepime has been shown to be very well tolerated and effective in the treatment of a variety of infections including moderate-to-severe pneumonia (including cases associated with concurrent bacteremia), complicated and uncomplicated urinary tract infections (also including cases associated with concurrent bacteremia), and skin and skin-structure infections." | ( Bacteriologic and clinical applications of a new extended-spectrum parenteral cephalosporin. Levin, S; Segreti, J, 1996) | 1.02 |
| "Cefepime has a high affinity for penicillin-binding proteins and, due to its zwitterionic configuration, rapidly penetrates outer-membrane porin channels of bacteria." | ( Cefepime: a fourth-generation parenteral cephalosporin. Paladino, JA; Wynd, MA, 1996) | 2.46 |
| "Cefepime has been used in clinical therapeutic trials for meningitis, serious infection and febrile neutropenia, comprising more than 800 pediatric patients. " | ( Cefepine vs. ceftazidime treatment of pyelonephritis: a European, randomized, controlled study of 300 pediatric cases. European Society for Paediatric Infectious Diseases (ESPID) Pyelonephritis Study Group. Ashkenazi, S; Boulesteix, J; De Pril, V; Eskola, J; Fishbach, M; Grès, JJ; Kafetzis, D; Rollin, C; Schaad, UB; Syriopoulou, V, 1998) | 1.74 |
| "Cefepime has a spectrum of activity almost as broad as that of the carbapenems." | ( Multicentre study of the in vitro activity of cefepime, a broad-spectrum cephalosporin, compared to other broad-spectrum agents. Bell, JM; Turnidge, JD, 2001) | 1.29 |
Cefepime may be a cause of MSE in non-anoxic comatose patients. Only cefepIME was able to inhibit all inducible Enterobacteriaceae.
| Excerpt | Reference | Relevance |
|---|---|---|
| "Cefepime may be a cause of MSE in non-anoxic comatose patients. " | ( Usefulness of bilateral bispectral index (BIS) monitoring in a comatose patient with myoclonic status epilepticus secondary to cefepime. Fernández-Torre, JL; González-Quintanilla, V; Hernández-Hernández, MA; Rodríguez-Borregán, JC, 2013) | 2.04 |
| "Only cefepime was able to inhibit all inducible Enterobacteriaceae." | ( Comparative in vitro activity of cefepime against strains isolated from intensive care and haematology patients. Claeys, G; De Grauwe, E; Vanpoucke, H; Verschraegen, G, ) | 0.87 |
Cefepime treatment was better tolerated, with 9% of the patients experiencing related intercurrent events compared with 19% in the imipenem-cilastatin group (P = 0.003) The treatment with cefepim + amikacin was successful in 38 out of 40 patients (95%)
Cefepime-induced neurotoxicity (CIN) is an increasingly reported adverse event. Electroretinographic patterns at one and two weeks indicated a toxic response to 20 mg of cefepim. The results of this study suggest that cefapime is as safe and effective as ceftazidime for the treatment of serious infections in adult hospitalized Chinese patients.
Cefepime has the required pharmacokinetic properties to be considered for pre-operative antimicrobial prophylaxis in patients undergoing biliary tract surgery. Meropenem, imipenem, cefepIME, ceftazidime (2 g every 8 hrs), and piperacillin/tazobactam have high probabilities of achieving adequate pharmacodynamic exposures.
The aim of the present study was to evaluate the in vitro bactericidal activity of the new broad spectrum cephalosporins cefepime (FEP) and cefpirome (CPO) against Acinetobacter baumannii, Stenotrophomonas maltophilia and Enterobacter cloacae.
Cefepime displayed a linear pharmacokinetic profile, was well-absorbed via im injection and had adequate penetration into the CSF of patients with bacterial meningitis. The systemic bioavailability (F) after intramuscular administration of cefepIME in calves was 95%. More than 80% of the administered dose was excreted in the urine as unchanged cefapime.
Cefepime dosed 30 to 50 mg/kg per dose every 12 hours may be appropriate to achieve a concentration two to four times above an MIC ≤ 8 mg/L for at least 60% of the dosing interval in neonatal patients. To balance the target attainment and potential neurotoxicity, 3 g/day continuous infusion appears to be a better dosing regimen than 6 g/ day continuous infusion.
| Role | Description |
|---|---|
| antibacterial drug | A drug used to treat or prevent bacterial infections. |
| [role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Class | Description |
|---|---|
| cephalosporin | A class of beta-lactam antibiotics differing from the penicillins in having a 6-membered, rather than a 5-membered, side ring. Although cephalosporins are among the most commonly used antibiotics in the treatment of routine infections, and their use is increasing over time, they can cause a range of hypersensitivity reactions, from mild, delayed-onset cutaneous reactions to life-threatening anaphylaxis in patients with immunoglobulin E (IgE)-mediated allergy. |
| oxime O-ether | O-organyl oximes R2C=NOR' (R' =/= H). |
| [compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Solute carrier family 15 member 1 | Homo sapiens (human) | Ki | 30,000.0000 | 0.1800 | 3.3933 | 9.8000 | AID238858; AID681115 |
| Solute carrier family 15 member 2 | Homo sapiens (human) | Ki | 10,982.3999 | 0.7943 | 4.2210 | 8.0000 | AID612540 |
| Solute carrier family 15 member 2 | Rattus norvegicus (Norway rat) | Ki | 11,400.0000 | 3.0000 | 6.4778 | 8.5000 | AID681114 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Beta-lactamase | Citrobacter freundii | Km | 16.0000 | 5.0000 | 7.0000 | 9.0000 | AID405084 |
| Beta-lactamase | Citrobacter gillenii | Km | 2,685.0000 | 10.0000 | 10.0000 | 10.0000 | AID285442 |
| Beta-lactamase | Escherichia coli | Km | 73.0000 | 1.1000 | 4.7667 | 9.4000 | AID394487 |
| Beta-lactamase | Shouchella clausii | Km | 1,000.0000 | 0.0100 | 3.0050 | 6.0000 | AID373209 |
| Beta-lactamase | Acinetobacter baumannii | Km | 1,300.0000 | 3.0000 | 5.6667 | 9.0000 | AID567279 |
| Beta-lactamase | Burkholderia cenocepacia | Km | 1,000.0000 | 10.0000 | 10.0000 | 10.0000 | AID541022 |
| Metallo-beta-lactamase type 2 | Klebsiella pneumoniae | Km | 77.0000 | 8.0000 | 9.3333 | 10.0000 | AID563972 |
| Metallo-beta-lactamase VIM-11 | Pseudomonas aeruginosa | Km | 1,200.0000 | 4.5000 | 7.0000 | 9.4000 | AID520385 |
| Metallo-beta-lactamase VIM-2 | Pseudomonas aeruginosa | Km | 1,200.0000 | 5.5000 | 7.8750 | 9.9000 | AID520386 |
| Beta-lactamase | Pseudomonas aeruginosa | Km | 0.3000 | 0.3000 | 2.0063 | 8.0000 | AID495661 |
| Beta-lactamase | Aeromonas allosaccharophila | Km | 2,000.0000 | 1.5000 | 6.3000 | 10.0000 | AID584846 |
| Metallo-beta-lactamase | Stutzerimonas stutzeri | Km | 220.0000 | 3.5000 | 4.7500 | 6.0000 | AID518728 |
| Beta-lactamase | Acinetobacter baumannii | Km | 1,800.0000 | 6.0000 | 7.6667 | 10.0000 | AID567280 |
| Beta-lactamase | Staphylococcus aureus | Km | 61.0000 | 1.0000 | 2.2000 | 3.4000 | AID368313 |
| Beta-lactamase | Enterobacter cloacae | Km | 237.6667 | 2.9000 | 6.4364 | 9.8000 | AID368498; AID368523; AID368527 |
| Beta-lactamase SHV-1 | Klebsiella pneumoniae | Km | 115.0000 | 4.2000 | 4.2500 | 4.3000 | AID368307; AID519983 |
| Beta-lactamase | Serratia marcescens | Km | 800.0000 | 2.1000 | 2.1000 | 2.1000 | AID368725 |
| Beta-lactamase | Pseudomonas aeruginosa PAO1 | Km | 329.6000 | 0.5000 | 4.2444 | 8.0000 | AID368539; AID368543; AID368547; AID368729; AID546426 |
| Kappa-type opioid receptor | Cavia porcellus (domestic guinea pig) | Km | 2,685.0000 | 10.0000 | 10.0000 | 10.0000 | AID285442 |
| Beta-lactamase TEM | Escherichia coli | Km | 650.0000 | 5.4000 | 6.3000 | 7.2000 | AID368309 |
| Beta-lactamase | Morganella morganii | Km | 690.0000 | 7.9000 | 7.9000 | 7.9000 | AID368531 |
| B2 metallo-beta-lactamase | Chryseobacterium indologenes | Km | 300.0000 | 3.0000 | 3.0000 | 3.0000 | AID562337 |
| Metallo-beta-lactamase VIM-2 | Klebsiella pneumoniae | Km | 184.0000 | 5.0000 | 7.5000 | 10.0000 | AID563976 |
| Beta-lactamase | Klebsiella pneumoniae | Km | 149.0000 | 5.0000 | 7.1667 | 10.0000 | AID519982 |
| Metallo-beta-lactamase | Escherichia coli | Km | 400.0000 | 2.0000 | 6.8571 | 10.0000 | AID583083; AID583084; AID583085; AID583094 |
| Beta-lactamase | Serratia marcescens | Km | 280.0000 | 2.2000 | 4.6000 | 8.2000 | AID368509 |
| Beta-lactamase | Klebsiella pneumoniae | Km | 300.0000 | 1.0000 | 4.4500 | 7.9000 | AID1320835 |
| BlaVIM-1 | Escherichia coli | Km | 145.0000 | 1.5000 | 1.5000 | 1.5000 | AID495914 |
| Beta-lactamase | Pseudomonas aeruginosa | Km | 1,700.0000 | 0.5000 | 2.7500 | 5.0000 | AID546429 |
| Beta-lactamase | Escherichia coli | Km | 180.0000 | 7.1000 | 8.1667 | 8.7000 | AID368492 |
| Beta-lactamase class B VIM-2 | Pseudomonas aeruginosa | Km | 206.6667 | 2.0000 | 6.6500 | 9.4000 | AID368514; AID529659; AID531315 |
| Beta-lactamase VIM-1 | Pseudomonas aeruginosa | Km | 337.0000 | 4.0000 | 4.0000 | 4.0000 | AID530340 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID542058 | Antibacterial activity against Klebsiella pneumoniae C expressing CTX-M group 1 beta-lactamase by Etest method in presence of clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Nationwide survey of CTX-M-type extended-spectrum beta-lactamases among Klebsiella pneumoniae isolates in Slovenian hospitals. |
| AID496004 | Antimicrobial activity against drug resistant Pseudomonas aeruginosa isolates by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vitro potency of CXA-101, a novel cephalosporin, against Pseudomonas aeruginosa displaying various resistance phenotypes, including multidrug resistance. |
| AID555671 | Antimicrobial activity against Escherichia coli DH5[alpha] harboring recombinant plasmid carrying CTX-M-53 gene by disk diffusion method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Novel plasmid-encoded ceftazidime-hydrolyzing CTX-M-53 extended-spectrum beta-lactamase from Salmonella enterica serotypes Westhampton and Senftenberg. |
| AID564228 | Activity of Escherichia coli TOP10 beta-lactamase OXA-143 | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | OXA-143, a novel carbapenem-hydrolyzing class D beta-lactamase in Acinetobacter baumannii. |
| AID564467 | Antimicrobial activity against Pseudomonas aeruginosa isolate 1080 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | In vivo efficacy of 1- and 2-gram human simulated prolonged infusions of doripenem against Pseudomonas aeruginosa. |
| AID521286 | Antimicrobial activity against CTX-M-2 and TEM-1 producing Klebsiella pneumoniae transconjugants/transformants with PFGE pulsotype J by Etest | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Multiclonal outbreak of Klebsiella pneumoniae producing extended-spectrum beta-lactamase CTX-M-2 and novel variant CTX-M-59 in a neonatal intensive care unit in Brazil. |
| AID528976 | Antimicrobial activity against methicillin-susceptible Staphylococcus aureus isolated from ICU patient urine assessed as resistant isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Antimicrobial-resistant pathogens in intensive care units in Canada: results of the Canadian National Intensive Care Unit (CAN-ICU) study, 2005-2006. |
| AID522008 | Antimicrobial activity against Escherichia coli isolate J53 harboring pI-2 containing beta-lactamase OXA-48 located within transposon Tn1999.2 by Etest method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Spread of OXA-48-encoding plasmid in Turkey and beyond. |
| AID559684 | Antibacterial activity against Acinetobacter baumannii BM4652 | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | GES-11, a novel integron-associated GES variant in Acinetobacter baumannii. |
| AID368496 | Activity of Klebsiella oxytoca beta-lactamase K1 assessed as drug hydrolysis by spectrophotometry relative to cephaloridine | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID285652 | Antimicrobial activity against Pseudomonas aeruginosa 19C7 tracheal isolates from mechanically ventilated chronic respiratory insufficiency patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID522572 | Antimicrobial activity against Escherichia coli isolate 7014517 with AmpC beta-lactamase 295 Ins LAA mutation | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Occurrence of ST23 complex phylogroup A Escherichia coli isolates producing extended-spectrum AmpC beta-lactamase in a French hospital. |
| AID285619 | Antimicrobial activity against Pseudomonas aeruginosa 5G3 tracheal isolates from mechanically ventilated chronic respiratory insufficiency patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID587522 | Antimicrobial activity against carbapenemases KPC-producing Klebsiella pneumoniae VA-361 infected in sc dosed CD-1 mouse in presence of 1 ug/ml NXL104 beta-lactamase inhibitor | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1 | Evaluation of ceftazidime and NXL104 in two murine models of infection due to KPC-producing Klebsiella pneumoniae. |
| AID511399 | Antibacterial activity against Haemophilus influenzae by broth dilution method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Comparative in vitro activities of nemonoxacin (TG-873870), a novel nonfluorinated quinolone, and other quinolones against clinical isolates. |
| AID574430 | Antimicrobial activity against Escherichia coli isolate 386T expressing beta-lactamase KPC2, OXA-9 and PFGE cluster 1 isolated from wound of patient by vitek-2 method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Carbapenem-resistant KPC-2-producing Escherichia coli in a Tel Aviv Medical Center, 2005 to 2008. |
| AID368547 | Activity of Pseudomonas aeruginosa MK-1184 AmpC assessed as drug hydrolysis by spectrophotometry | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID1373318 | Antimicrobial activity against Escherichia coli expressing beta-lactamase Oxa-40 by CLSI broth microdilution method | 2018 | Bioorganic & medicinal chemistry letters, 02-15, Volume: 28, Issue:4 | Optimization of novel monobactams with activity against carbapenem-resistant Enterobacteriaceae - Identification of LYS228. |
| AID498820 | Antimicrobial activity against Klebsiella pneumoniae WH76 expressing IMP-4, TEM-1, SHV-14, CTX-M-3, qnrS1 by CLSI method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Phenotypic and genotypic characterization of Enterobacteriaceae with decreased susceptibility to carbapenems: results from large hospital-based surveillance studies in China. |
| AID373769 | Antibacterial activity against imipenem-resistant Acinetobacter baumannii abh20 by broth dilution method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | An OXA-66/OXA-51-like carbapenemase and possibly an efflux pump are associated with resistance to imipenem in Acinetobacter baumannii. |
| AID546181 | Antimicrobial activity against AmpC overproducing Pseudomonas aeruginosa isolate Pae-beta-21 with PDC-4 variant by Etest | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Extended-spectrum cephalosporinases in Pseudomonas aeruginosa. |
| AID571932 | Antimicrobial activity against Escherichia coli MC4100 harboring a weak promoter in beta-lactamase GES-1 by Etest | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Relative strengths of the class 1 integron promoter hybrid 2 and the combinations of strong and hybrid 1 with an active p2 promoter. |
| AID1318920 | Antibacterial activity against multidrug/extremely drug-resistant/colistin-susceptible Pseudomonas aeruginosa isolate 259-96918 | 2016 | Journal of medicinal chemistry, 09-22, Volume: 59, Issue:18 | Hybrid Antibiotic Overcomes Resistance in P. aeruginosa by Enhancing Outer Membrane Penetration and Reducing Efflux. |
| AID279815 | Antimicrobial activity against Escherichia coli DH5-alpha with pGEM-T EASY expressing TEM1 gene by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2 | Plasmid-mediated KPC-2 in a Klebsiella pneumoniae isolate from China. |
| AID541495 | Antimicrobial activity against Burkholderia cepacia clinical isolate after 18 to 22 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Establishment of in vitro susceptibility testing methodologies and comparative activities of piperacillin in combination with the penem {beta}-lactamase inhibitor BLI-489. |
| AID542063 | Antibacterial activity against Klebsiella pneumoniae B expressing CTX-M group 1 beta-lactamase by Etest method | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Nationwide survey of CTX-M-type extended-spectrum beta-lactamases among Klebsiella pneumoniae isolates in Slovenian hospitals. |
| AID567305 | Antimicrobial activity against SHV-12 ESBL producing Pseudomonas aeruginosa isolate 2203 isolated from burn patient by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Acquisition of a transposon encoding extended-spectrum beta-lactamase SHV-12 by Pseudomonas aeruginosa isolates during the clinical course of a burn patient. |
| AID544682 | Antimicrobial activity against AmpC beta-lactamase-producing Serratia marcescens clinical isolate after 18 to 22 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Establishment of in vitro susceptibility testing methodologies and comparative activities of piperacillin in combination with the penem {beta}-lactamase inhibitor BLI-489. |
| AID561678 | Antimicrobial activity against Pseudomonas aeruginosa isolate OC14551 harboring plasmid MexZ expressing mexXY gene by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Effect of MexXY overexpression on ceftobiprole susceptibility in Pseudomonas aeruginosa. |
| AID567316 | Antimicrobial activity against SHV-12 ESBL producing Pseudomonas aeruginosa isolate 2207 isolated from burn patient by broth microdilution method in presence of beta-lactamase inhibitor clavulanic acid | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Acquisition of a transposon encoding extended-spectrum beta-lactamase SHV-12 by Pseudomonas aeruginosa isolates during the clinical course of a burn patient. |
| AID511586 | Antimicrobial activity against beta-lactam resistant Pseudomonas aeruginosa PAOD2 harboring oprD spontaneous mutant and deficient in ampD gene by selected in vitro after antipseudomonal treatment of intensive care unit patient by broth microdilution metho | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Activity of a new cephalosporin, CXA-101 (FR264205), against beta-lactam-resistant Pseudomonas aeruginosa mutants selected in vitro and after antipseudomonal treatment of intensive care unit patients. |
| AID405821 | Antimicrobial activity against Acinetobacter baumannii 695 isolate harboring bla IMP-1 carrying integron In86 containing aminoglycoside resistance gene aac(6')-3 | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | Characterization of an integron carrying blaIMP-1 and a new aminoglycoside resistance gene, aac(6')-31, and its dissemination among genetically unrelated clinical isolates in a Brazilian hospital. |
| AID542064 | Antibacterial activity against Klebsiella pneumoniae C expressing CTX-M group 1 beta-lactamase by Etest method | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Nationwide survey of CTX-M-type extended-spectrum beta-lactamases among Klebsiella pneumoniae isolates in Slovenian hospitals. |
| AID534385 | Antibacterial activity against Escherichia coli K-12 W1895 by microdilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | KHM-1, a novel plasmid-mediated metallo-beta-lactamase from a Citrobacter freundii clinical isolate. |
| AID560069 | Antimicrobial activity against Klebsiella pneumoniae isolate 5427 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | In vitro activity of ceftaroline alone and in combination against clinical isolates of resistant gram-negative pathogens, including beta-lactamase-producing Enterobacteriaceae and Pseudomonas aeruginosa. |
| AID285653 | Antimicrobial activity against Pseudomonas aeruginosa 19C12 tracheal isolates from mechanically ventilated chronic respiratory insufficiency patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID373051 | Antimicrobial activity against Bacillus clausii ATCC 21537 by agar-dilution technique | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Molecular and biochemical characterization of the chromosome-encoded class A beta-lactamase BCL-1 from Bacillus clausii. |
| AID573335 | Antibacterial activity against ceftazidime-susceptible Enterobacteriaceae assessed as susceptible isolates by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID534647 | Antimicrobial activity against Non-ESBL Klebsiella pneumoniae assessed as susceptible isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activity of doripenem, a carbapenem for the treatment of challenging infections caused by gram-negative bacteria, against recent clinical isolates from the United States. |
| AID625283 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for elevated liver function tests | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID285663 | Antimicrobial activity against Pseudomonas aeruginosa 22D6 tracheal isolates from mechanically ventilated chronic respiratory insufficiency patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID1079937 | Severe hepatitis, defined as possibly life-threatening liver failure or through clinical observations. Value is number of references indexed. [column 'MASS' in source] | |||
| AID508487 | Antimicrobial activity against Pseudomonas aeruginosa isolate BNL-1681 producing metallo-beta-lactamase VIM2 by Etest | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Molecular epidemiology of metallo-beta-lactamase-producing Pseudomonas aeruginosa isolates from Norway and Sweden shows import of international clones and local clonal expansion. |
| AID528979 | Antimicrobial activity against carbapenem-resistant Enterobacter cloacae isolated from ICU patient respiratory tract assessed as resistant isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Antimicrobial-resistant pathogens in intensive care units in Canada: results of the Canadian National Intensive Care Unit (CAN-ICU) study, 2005-2006. |
| AID546413 | Antimicrobial activity against Pseudomonas aeruginosa isolate Pae-beta-30 with PDC-8 variant by Etest | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Extended-spectrum cephalosporinases in Pseudomonas aeruginosa. |
| AID561660 | Antimicrobial activity against Pseudomonas aeruginosa isolate OC16830 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Effect of MexXY overexpression on ceftobiprole susceptibility in Pseudomonas aeruginosa. |
| AID573358 | Antibacterial activity against ceftazidime-susceptible Klebsiella pneumoniae by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID576071 | Antimicrobial activity against ESBL-positive Klebsiella pneumoniae 50748 harboring porin OmpK36 gene by Etest | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | An ertapenem-resistant extended-spectrum-beta-lactamase-producing Klebsiella pneumoniae clone carries a novel OmpK36 porin variant. |
| AID285638 | Antimicrobial activity against Pseudomonas aeruginosa 13D3 tracheal isolates from mechanically ventilated chronic respiratory insufficiency patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID368508 | Ratio of Kcat to Km of Escherichia coli KPC2 assessed as drug hydrolysis by spectrophotometry relative to cephaloridine | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID554395 | Antimicrobial activity against Pseudomonas aeruginosa isolate 2716 obtained from cystic fibrosis patient by disk diffusion method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Efflux unbalance in Pseudomonas aeruginosa isolates from cystic fibrosis patients. |
| AID517955 | Antimicrobial activity against Klebsiella pneumoniae by broth dilution method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli. |
| AID520713 | Antibacterial activity against Escherichia coli TOP10 harboring pOXA-97 | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Carbapenem-resistant Acinetobacter baumannii isolates from Tunisia producing the OXA-58-like carbapenem-hydrolyzing oxacillinase OXA-97. |
| AID587531 | Antimicrobial activity against carbapenemases KPC-producing Klebsiella pneumoniae VA-406 infected in sc dosed CD-1 mouse in presence of 4 ug/ml Tazobactam beta-lactamase inhibitor | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1 | Evaluation of ceftazidime and NXL104 in two murine models of infection due to KPC-producing Klebsiella pneumoniae. |
| AID301085 | Antibacterial activity against AmpC hyperproducing Pseudomonas aeruginosa SR24-12 after 20 hrs by agar dilution method | 2007 | Bioorganic & medicinal chemistry, Nov-01, Volume: 15, Issue:21 | A novel series of parenteral cephalosporins exhibiting potent activities against Pseudomonas aeruginosa and other Gram-negative pathogens: synthesis and structure-activity relationships. |
| AID511386 | Antibacterial activity against ciprofloxacin resistant Escherichia coli by broth dilution method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Comparative in vitro activities of nemonoxacin (TG-873870), a novel nonfluorinated quinolone, and other quinolones against clinical isolates. |
| AID508480 | Antimicrobial activity against Pseudomonas aeruginosa isolate AK5493 producing metallo-beta-lactamase VIM2 by Etest | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Molecular epidemiology of metallo-beta-lactamase-producing Pseudomonas aeruginosa isolates from Norway and Sweden shows import of international clones and local clonal expansion. |
| AID517954 | Antimicrobial activity against Klebsiella oxytoca by broth dilution method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli. |
| AID521354 | Antimicrobial activity against Streptococcus pneumoniae isolate 4134 obtained from sputum of patient | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Highly variable penicillin resistance determinants PBP 2x, PBP 2b, and PBP 1a in isolates of two Streptococcus pneumoniae clonal groups, Poland 23F-16 and Poland 6B-20. |
| AID625292 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) combined score | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID368543 | Activity of Pseudomonas aeruginosa 18SH AmpC assessed as drug hydrolysis by spectrophotometry | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID546165 | Antimicrobial activity against Pseudomonas aeruginosa isolate Pae-beta-05 with PDC-2 variant by Etest | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Extended-spectrum cephalosporinases in Pseudomonas aeruginosa. |
| AID565771 | Antimicrobial activity against Pseudomonas aeruginosa OC 12070 expressing 107 fold elevated mexX expression and 155 fold elevated mexY expression by broth macrodilution method | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | Differential selection of single-step AmpC or efflux mutants of Pseudomonas aeruginosa by using cefepime, ceftazidime, or ceftobiprole. |
| AID535128 | Antimicrobial activity against Ceftazidime non-susceptible Pseudomonas aeruginosa by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activity of doripenem, a carbapenem for the treatment of challenging infections caused by gram-negative bacteria, against recent clinical isolates from the United States. |
| AID582764 | Antimicrobial activity against eaeA negative verocytotoxin-producing non-O157 Escherichia coli isolates obtained from human assessed as percentage of resistant isolates | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Antimicrobial resistance testing of verocytotoxin-producing Escherichia coli and first description of TEM-52 extended-spectrum β-lactamase in serogroup O26. |
| AID582980 | Antimicrobial activity against ampC::lox gene-deficient Pseudomonas aeruginosa PAO1 by Etest method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | NagZ inactivation prevents and reverts beta-lactam resistance, driven by AmpD and PBP 4 mutations, in Pseudomonas aeruginosa. |
| AID519982 | Activity of Klebsiella pneumoniae Beta-Lactamase SHV-55 | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Biochemical characterization of SHV-55, an extended-spectrum class A beta-lactamase from Klebsiella pneumoniae. |
| AID368531 | Activity of Morganella morganii AmpC assessed as drug hydrolysis by spectrophotometry | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID534088 | Antibacterial activity against penicillin-susceptible Streptococcus pneumoniae isolate by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | In vitro activity of ceftaroline against Streptococcus pneumoniae isolates exhibiting resistance to penicillin, amoxicillin, and cefotaxime. |
| AID534097 | Antibacterial activity against Acinetobacter baumannii PFGE type A isolate by microdilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | A plasmid-borne blaOXA-58 gene confers imipenem resistance to Acinetobacter baumannii isolates from a Lebanese hospital. |
| AID285365 | Susceptibility of qnr positive Enterobacter cloacae producing IMP8 and/or SHV2 assessed as percentage nonsusceptible isolates | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Prevalence of plasmid-mediated quinolone resistance determinants QnrA, QnrB, and QnrS among clinical isolates of Enterobacter cloacae in a Taiwanese hospital. |
| AID529900 | Antimicrobial activity against Leptospira interrogans serovar Icterohaemorrhagiae isolate 9 by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Antimicrobial susceptibilities of geographically diverse clinical human isolates of Leptospira. |
| AID368503 | Ratio of Kcat to Km of Klebsiella pneumoniae TEM26 assessed as drug hydrolysis by spectrophotometry | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID573208 | Antimicrobial activity against mutS::lox-deficient Pseudomonas aeruginosa PAOMSB biofilm harboring nfxB C116T mutant gene selected at 4 ug/ml of azithromycin after 5 passages by Etest method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Azithromycin in Pseudomonas aeruginosa biofilms: bactericidal activity and selection of nfxB mutants. |
| AID499129 | Antimicrobial activity against Pseudomonas aeruginosa OC 4351 infected in immunocompromized SKH1 mouse assessed as log change in bacterial colony forming unit at 100 mg/kg/day, sc | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vivo activity of ceftobiprole in murine skin infections due to Staphylococcus aureus and Pseudomonas aeruginosa. |
| AID544912 | Antimicrobial activity against Proteus vulgaris clinical isolate after 18 to 22 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Establishment of in vitro susceptibility testing methodologies and comparative activities of piperacillin in combination with the penem {beta}-lactamase inhibitor BLI-489. |
| AID559918 | Antibacterial activity against Escherichia coli TOP10 harboring beta-lactamase RTG4 gene by Etest method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Genetic and biochemical characterization of the first extended-spectrum CARB-type beta-lactamase, RTG-4, from Acinetobacter baumannii. |
| AID573376 | Antibacterial activity against imipenem-susceptible Acinetobacter by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID285585 | Antimicrobial activity against Pseudomonas aeruginosa 65.33-4 tracheal isolates from mechanically ventilated tuberculosis patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID285621 | Antimicrobial activity against Pseudomonas aeruginosa 8A2 tracheal isolates from mechanically ventilated chronic respiratory insufficiency patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID510502 | Antibacterial activity against Acinetobacter calcoaceticus/baumannii complex isolate C1AC9-24 expressing KPC beta lactamase | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Detection of KPC in Acinetobacter spp. in Puerto Rico. |
| AID556669 | Antimicrobial activity against multidrug resistant Enterobacter aerogenes isolate 24 by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Occurrence of efflux mechanism and cephalosporinase variant in a population of Enterobacter aerogenes and Klebsiella pneumoniae isolates producing extended-spectrum beta-lactamases. |
| AID562337 | Activity at Chryseobacterium indologenes 597 metallo-beta-lactamase IND-6 expressed in Escherichia coli DH5alpha by Michaelis-Menten equation | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | IND-6, a highly divergent IND-type metallo-beta-lactamase from Chryseobacterium indologenes strain 597 isolated in Burkina Faso. |
| AID1604440 | Antibacterial activity against Escherichia coli by CLSI based microdilution method | 2020 | Journal of medicinal chemistry, 03-12, Volume: 63, Issue:5 | β-Lactamase Inhibitors To Restore the Efficacy of Antibiotics against Superbugs. |
| AID325191 | Antibacterial activity against AmpC producing Enterobacter cloacae SR-4321 by standard serial agar dilution method | 2008 | Bioorganic & medicinal chemistry, Feb-15, Volume: 16, Issue:4 | A novel series of parenteral cephalosporins exhibiting potent activities against both Pseudomonas aeruginosa and other gram-negative pathogens. Part 2: Synthesis and structure-activity relationships. |
| AID524930 | Antimicrobial activity against Escherichia coli MI1443 harboring N106S and D240G mutations in beta lactamase CTX-M-10 by E-test | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Mutational events in cefotaximase extended-spectrum beta-lactamases of the CTX-M-1 cluster involved in ceftazidime resistance. |
| AID534925 | Antimicrobial activity against Ceftazidime susceptible Serratia marcescens assessed as intermediate isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activity of doripenem, a carbapenem for the treatment of challenging infections caused by gram-negative bacteria, against recent clinical isolates from the United States. |
| AID323039 | Antimicrobial activity against extended-spectrum-beta-lactamase producing Klebsiella pneumoniae isolates | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Predictors of mortality in patients with bloodstream infections caused by extended-spectrum-beta-lactamase-producing Enterobacteriaceae: importance of inadequate initial antimicrobial treatment. |
| AID285511 | Antibacterial activity against Enterobacter sp. | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | In vitro and in vivo antibacterial activities of heteroaryl isothiazolones against resistant gram-positive pathogens. |
| AID565517 | Antibacterial activity against oprD, mexB, mexY and mexD expressing Pseudomonas aeruginosa isolate Paebeta-18 harboring A residue at 105 position in PDC- 3 by Etest method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Molecular epidemiology and mechanisms of carbapenem resistance in Pseudomonas aeruginosa. |
| AID323040 | Antimicrobial activity against extended-spectrum-beta-lactamase producing Klebsiella pneumoniae assessed as percent resistant isolates | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Predictors of mortality in patients with bloodstream infections caused by extended-spectrum-beta-lactamase-producing Enterobacteriaceae: importance of inadequate initial antimicrobial treatment. |
| AID520778 | Antibacterial activity against beta-lactamase KPC-2 producing Escherichia coli isolate E1 by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Emergence of Serratia marcescens, Klebsiella pneumoniae, and Escherichia coli Isolates possessing the plasmid-mediated carbapenem-hydrolyzing beta-lactamase KPC-2 in intensive care units of a Chinese hospital. |
| AID564529 | Antimicrobial activity against Escherichia coli TOP10 harboring pADC-11 plasmid by Etest method | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | Extended-spectrum cephalosporinase in Acinetobacter baumannii. |
| AID1079933 | Acute liver toxicity defined via clinical observations and clear clinical-chemistry results: serum ALT or AST activity > 6 N or serum alkaline phosphatases activity > 1.7 N. This category includes cytolytic, choleostatic and mixed liver toxicity. Value is | |||
| AID544921 | Antimicrobial activity against Acinetobacter calcoaceticus clinical isolate after 18 to 22 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Establishment of in vitro susceptibility testing methodologies and comparative activities of piperacillin in combination with the penem {beta}-lactamase inhibitor BLI-489. |
| AID508482 | Antimicrobial activity against Pseudomonas aeruginosa isolate K34-73 producing metallo-beta-lactamase VIM4 by Etest | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Molecular epidemiology of metallo-beta-lactamase-producing Pseudomonas aeruginosa isolates from Norway and Sweden shows import of international clones and local clonal expansion. |
| AID1079932 | Highest frequency of moderate liver toxicity observed during clinical trials, expressed as a percentage. [column '% BIOL' in source] | |||
| AID534622 | Antimicrobial activity against Non-ESBL Escherichia coli by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activity of doripenem, a carbapenem for the treatment of challenging infections caused by gram-negative bacteria, against recent clinical isolates from the United States. |
| AID511577 | Antimicrobial activity against beta-lactam resistant Pseudomonas aeruginosa PAO1 by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Activity of a new cephalosporin, CXA-101 (FR264205), against beta-lactam-resistant Pseudomonas aeruginosa mutants selected in vitro and after antipseudomonal treatment of intensive care unit patients. |
| AID368529 | Ratio of Kcat to Km of Enterobacter cloacae 908R AmpC assessed as drug hydrolysis by spectrophotometry | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID531584 | Antibacterial activity against Escherichia coli obtained from complicated skin and skin structure infections by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro activity of ceftobiprole against pathogens from two phase 3 clinical trials of complicated skin and skin structure infections. |
| AID531581 | Antibacterial activity against Citrobacter freundii obtained from complicated skin and skin structure infections by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro activity of ceftobiprole against pathogens from two phase 3 clinical trials of complicated skin and skin structure infections. |
| AID519183 | Antimicrobial activity against MexXY-OprM-overproducing Pseudomonas aeruginosa PAO1 harboring MexY agrW mutant and MexZ mutant gene selected after 4 ug/ml of cefepime exposure | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Relationship between antibiotic use and incidence of MexXY-OprM overproducers among clinical isolates of Pseudomonas aeruginosa. |
| AID541501 | Antimicrobial activity against Pseudomonas aeruginosa clinical isolate after 18 to 22 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Establishment of in vitro susceptibility testing methodologies and comparative activities of piperacillin in combination with the penem {beta}-lactamase inhibitor BLI-489. |
| AID342018 | Antibacterial activity against Klebsiella pneumoniae NK29 by Etest | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8 | Sequencing and comparative genomic analysis of pK29, a 269-kilobase conjugative plasmid encoding CMY-8 and CTX-M-3 beta-lactamases in Klebsiella pneumoniae. |
| AID625284 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for hepatic failure | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID534906 | Antimicrobial activity against Citrobacter with nonderepressed AmpC beta-lactamsae assessed as resistant isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activity of doripenem, a carbapenem for the treatment of challenging infections caused by gram-negative bacteria, against recent clinical isolates from the United States. |
| AID301092 | Antibacterial activity against Moraxella catarrhalis ATCC 43617 after 20 hrs by agar dilution method | 2007 | Bioorganic & medicinal chemistry, Nov-01, Volume: 15, Issue:21 | A novel series of parenteral cephalosporins exhibiting potent activities against Pseudomonas aeruginosa and other Gram-negative pathogens: synthesis and structure-activity relationships. |
| AID522022 | Antimicrobial activity against Escherichia coli isolate J53 harboring pEnc2 containing beta-lactamase OXA-48 located within transposon Tn1999 by Etest method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Spread of OXA-48-encoding plasmid in Turkey and beyond. |
| AID573338 | Antibacterial activity against ceftazidime-nonsusceptible Enterobacteriaceae assessed as susceptible isolates by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID573343 | Antibacterial activity against ceftazidime-nonsusceptible Citrobacter freundii by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID582975 | Antimicrobial activity against ampD::lox gene-deficient Pseudomonas aeruginosa PAO1 harboring dacB gene by Etest method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | NagZ inactivation prevents and reverts beta-lactam resistance, driven by AmpD and PBP 4 mutations, in Pseudomonas aeruginosa. |
| AID531757 | Antibacterial activity against Pseudomonas aeruginosa 1956 by twofold serial dilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Resistance and virulence of Pseudomonas aeruginosa clinical strains overproducing the MexCD-OprJ efflux pump. |
| AID530817 | Antibacterial activity against Escherichia coli J53 by Etest method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Plasmid-encoded carbapenem-hydrolyzing beta-lactamase OXA-48 in an imipenem-susceptible Klebsiella pneumoniae strain from Belgium. |
| AID582978 | Antimicrobial activity against ampD::lox, ampDh2::lox,ampDh3::lox and nagZ::lox gene-deficient Pseudomonas aeruginosa PAO1 by Etest method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | NagZ inactivation prevents and reverts beta-lactam resistance, driven by AmpD and PBP 4 mutations, in Pseudomonas aeruginosa. |
| AID567729 | Antimicrobial activity against wild type Pseudomonas aeruginosa | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | Differential selection of single-step AmpC or efflux mutants of Pseudomonas aeruginosa by using cefepime, ceftazidime, or ceftobiprole. |
| AID1079948 | Times to onset, minimal and maximal, observed in the indexed observations. [column 'DELAI' in source] | |||
| AID520975 | Antibacterial activity against Pseudomonas aeruginosa 2404 plasmid by Etest method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Genetic structures at the origin of acquisition of the beta-lactamase bla KPC gene. |
| AID681114 | TP_TRANSPORTER: inhibition of Gly-Sar uptake (pH6.0) in SKPT cells | 2005 | European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, Jan, Volume: 59, Issue:1 | Interaction of 31 beta-lactam antibiotics with the H+/peptide symporter PEPT2: analysis of affinity constants and comparison with PEPT1. |
| AID1373322 | Antimicrobial activity against Escherichia coli expressing beta-lactamase Oxa-160 by CLSI broth microdilution method | 2018 | Bioorganic & medicinal chemistry letters, 02-15, Volume: 28, Issue:4 | Optimization of novel monobactams with activity against carbapenem-resistant Enterobacteriaceae - Identification of LYS228. |
| AID587530 | Antimicrobial activity against carbapenemases KPC-producing Klebsiella pneumoniae VA-406 infected in sc dosed CD-1 mouse in presence of 4 ug/ml NXL104 beta-lactamase inhibitor | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1 | Evaluation of ceftazidime and NXL104 in two murine models of infection due to KPC-producing Klebsiella pneumoniae. |
| AID573355 | Antibacterial activity against ceftazidime-nonsusceptible Escherichia coli by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID511398 | Antibacterial activity against Pseudomonas aeruginosa by broth dilution method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Comparative in vitro activities of nemonoxacin (TG-873870), a novel nonfluorinated quinolone, and other quinolones against clinical isolates. |
| AID283530 | Antibacterial activity against Pseudomonas aeruginosa FE10 with inactivated nuoG gene by microdilution method | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3 | Cumulative effects of several nonenzymatic mechanisms on the resistance of Pseudomonas aeruginosa to aminoglycosides. |
| AID372609 | Antibacterial activity against Escherichia coli DH5alpha producing beta-lactamase TEM-35 by microdilution method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | TEM-158 (CMT-9), a new member of the CMT-type extended-spectrum beta-lactamases. |
| AID325192 | Antibacterial activity against Pseudomonas aeruginosa SR24 by standard serial agar dilution method | 2008 | Bioorganic & medicinal chemistry, Feb-15, Volume: 16, Issue:4 | A novel series of parenteral cephalosporins exhibiting potent activities against both Pseudomonas aeruginosa and other gram-negative pathogens. Part 2: Synthesis and structure-activity relationships. |
| AID301083 | Antibacterial activity against AmpC producing Enterobacter cloacae SR-4321 after 20 hrs by agar dilution method | 2007 | Bioorganic & medicinal chemistry, Nov-01, Volume: 15, Issue:21 | A novel series of parenteral cephalosporins exhibiting potent activities against Pseudomonas aeruginosa and other Gram-negative pathogens: synthesis and structure-activity relationships. |
| AID522388 | Activity of Aeromonas enteropelogenes Beta-lactamase TRU1 | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Genetic and biochemical characterization of TRU-1, the endogenous class C beta-lactamase from Aeromonas enteropelogenes. |
| AID556697 | Antimicrobial activity against multidrug resistant Escherichia coli DH5[alpha] harboring pACM204 plasmid by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Occurrence of efflux mechanism and cephalosporinase variant in a population of Enterobacter aerogenes and Klebsiella pneumoniae isolates producing extended-spectrum beta-lactamases. |
| AID511667 | Antimicrobial activity against beta-lactam resistant Pseudomonas aeruginosa PAOD1 harboring oprD spontaneous mutant and deficient in dacB gene selected in vitro after antipseudomonal treatment of intensive care unit patient by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Activity of a new cephalosporin, CXA-101 (FR264205), against beta-lactam-resistant Pseudomonas aeruginosa mutants selected in vitro and after antipseudomonal treatment of intensive care unit patients. |
| AID567741 | Antimicrobial activity against Pseudomonas aeruginosa OC 11678 expressing 30 fold elevated AmpC expression by broth macrodilution method | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | Differential selection of single-step AmpC or efflux mutants of Pseudomonas aeruginosa by using cefepime, ceftazidime, or ceftobiprole. |
| AID541549 | Antimicrobial activity against penicillin-intermediate Streptococcus pneumoniae clinical isolate after 18 to 22 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Establishment of in vitro susceptibility testing methodologies and comparative activities of piperacillin in combination with the penem {beta}-lactamase inhibitor BLI-489. |
| AID561659 | Antimicrobial activity against Pseudomonas aeruginosa isolate OC16827 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Effect of MexXY overexpression on ceftobiprole susceptibility in Pseudomonas aeruginosa. |
| AID498832 | Antimicrobial activity against carbapenem-resistant Klebsiella pneumoniae CY1 deficient in SHV-11, DHA-1, ompK35/36 by CLSI method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Phenotypic and genotypic characterization of Enterobacteriaceae with decreased susceptibility to carbapenems: results from large hospital-based surveillance studies in China. |
| AID498811 | Antimicrobial activity against Escherichia coli ZJ86T expressing KPC-2 by CLSI method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Phenotypic and genotypic characterization of Enterobacteriaceae with decreased susceptibility to carbapenems: results from large hospital-based surveillance studies in China. |
| AID535638 | Antimicrobial activity against Group B streptococcus serotype VI R2 harboring F395L, V405A, R433H, H438Y, and G648A mutations in PBP 2X and T567I mutation in PBP 2B by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | Genetic heterogeneity in pbp genes among clinically isolated group B Streptococci with reduced penicillin susceptibility. |
| AID544680 | Antimicrobial activity against AmpC beta-lactamase-producing Enterobacter aerogenes clinical isolate after 18 to 22 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Establishment of in vitro susceptibility testing methodologies and comparative activities of piperacillin in combination with the penem {beta}-lactamase inhibitor BLI-489. |
| AID546426 | Activity at Pseudomonas aeruginosa PDC-1 by spectrophotometer | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Extended-spectrum cephalosporinases in Pseudomonas aeruginosa. |
| AID368725 | Activity of Serratia marcescens AmpC assessed as drug hydrolysis by spectrophotometry | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID540944 | Antimicrobial activity against Escherichia coli DH5[alpha] transformant harboring pA172 plasmid expressing cephalosporinase CMY-31 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | CMY-31 and CMY-36 cephalosporinases encoded by ColE1-like plasmids. |
| AID535163 | Antimicrobial activity against imipenem susceptible Acinetobacter by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activity of doripenem, a carbapenem for the treatment of challenging infections caused by gram-negative bacteria, against recent clinical isolates from the United States. |
| AID529895 | Antimicrobial activity against Leptospira interrogans serovar Icterohaemorrhagiae isolate 3 by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Antimicrobial susceptibilities of geographically diverse clinical human isolates of Leptospira. |
| AID368316 | Antibacterial activity against Escherichia coli 6226 producing beta lactamase KPC2 by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID496005 | Antimicrobial activity against multidrug resistant Pseudomonas aeruginosa isolates by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vitro potency of CXA-101, a novel cephalosporin, against Pseudomonas aeruginosa displaying various resistance phenotypes, including multidrug resistance. |
| AID761206 | Antibacterial activity against Acinetobacter spp. by broth microdilution method | 2013 | Journal of medicinal chemistry, Jul-11, Volume: 56, Issue:13 | Pyridone-conjugated monobactam antibiotics with gram-negative activity. |
| AID573337 | Antibacterial activity against ceftazidime-nonsusceptible Enterobacteriaceae by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID529892 | Antimicrobial activity against Leptospira interrogans isolate 7 by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Antimicrobial susceptibilities of geographically diverse clinical human isolates of Leptospira. |
| AID495631 | Antimicrobial activity against Pseudomonas luteola LAM expressing blaLUT-1 by Etest method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Molecular and biochemical characterization of the natural chromosome-encoded class A beta-lactamase from Pseudomonas luteola. |
| AID524568 | Antimicrobial activity against Shigella sonnei isolate AM22451 by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Identification and characterization of CTX-M-producing Shigella isolates in the United States. |
| AID373770 | Antibacterial activity against imipenem-resistant Acinetobacter baumannii abh26 by broth dilution method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | An OXA-66/OXA-51-like carbapenemase and possibly an efflux pump are associated with resistance to imipenem in Acinetobacter baumannii. |
| AID541510 | Antimicrobial activity against Haemophilus parainfluenzae clinical isolate after 18 to 22 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Establishment of in vitro susceptibility testing methodologies and comparative activities of piperacillin in combination with the penem {beta}-lactamase inhibitor BLI-489. |
| AID1373298 | Antimicrobial activity against Escherichia coli expressing beta-lactamase TEM-1 by CLSI broth microdilution method | 2018 | Bioorganic & medicinal chemistry letters, 02-15, Volume: 28, Issue:4 | Optimization of novel monobactams with activity against carbapenem-resistant Enterobacteriaceae - Identification of LYS228. |
| AID519185 | Antimicrobial activity against MexXY-OprM-overproducing Pseudomonas aeruginosa PAO1 harboring MexY and MexZ mutant gene selected after 0.25 ug/ml of ciprofloxacin exposure | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Relationship between antibiotic use and incidence of MexXY-OprM overproducers among clinical isolates of Pseudomonas aeruginosa. |
| AID511387 | Antibacterial activity against ciprofloxacin susceptible Escherichia coli by broth dilution method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Comparative in vitro activities of nemonoxacin (TG-873870), a novel nonfluorinated quinolone, and other quinolones against clinical isolates. |
| AID544675 | Antimicrobial activity against class A extended spectrum beta-lactamase- and class D OXA- producing Escherichia coli clinical isolate after 18 to 22 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Establishment of in vitro susceptibility testing methodologies and comparative activities of piperacillin in combination with the penem {beta}-lactamase inhibitor BLI-489. |
| AID535130 | Antimicrobial activity against imipenem non-susceptible Pseudomonas aeruginosa by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activity of doripenem, a carbapenem for the treatment of challenging infections caused by gram-negative bacteria, against recent clinical isolates from the United States. |
| AID541531 | Antimicrobial activity against Enterococcus faecalis clinical isolate after 18 to 22 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Establishment of in vitro susceptibility testing methodologies and comparative activities of piperacillin in combination with the penem {beta}-lactamase inhibitor BLI-489. |
| AID541784 | Antimicrobial activity against Streptococcus pyogenes clinical isolate after 18 to 22 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Establishment of in vitro susceptibility testing methodologies and comparative activities of piperacillin in combination with the penem {beta}-lactamase inhibitor BLI-489. |
| AID531585 | Antibacterial activity against Klebsiella pneumoniae obtained from complicated skin and skin structure infections by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro activity of ceftobiprole against pathogens from two phase 3 clinical trials of complicated skin and skin structure infections. |
| AID531601 | Antimicrobial activity against Escherichia coli JM109 harboring pSC1 plasmid expressing beta-lactamase SHV-56 by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Molecular and biochemical characterization of SHV-56, a novel inhibitor-resistant beta-lactamase from Klebsiella pneumoniae. |
| AID283532 | Antibacterial activity against Pseudomonas aeruginosa FE53 with inactivated mexZ gene by microdilution method | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3 | Cumulative effects of several nonenzymatic mechanisms on the resistance of Pseudomonas aeruginosa to aminoglycosides. |
| AID534908 | Antimicrobial activity against Citrobacter with derepressed AmpC beta-lactamsae assessed as intermediate isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activity of doripenem, a carbapenem for the treatment of challenging infections caused by gram-negative bacteria, against recent clinical isolates from the United States. |
| AID520878 | Antibacterial activity against Achromobacter xylosoxidans LOL by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Characterization of a naturally occurring class D beta-lactamase from Achromobacter xylosoxidans. |
| AID535867 | Antimicrobial activity against aac(6')-Ib-cr-negative Enterobacter cloacae GZ51 harboring qnrA gene by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | High prevalence of plasmid-mediated quinolone resistance genes qnr and aac(6')-Ib-cr in clinical isolates of Enterobacteriaceae from nine teaching hospitals in China. |
| AID562577 | Antimicrobial activity against Escherichia coli NO8-1503 harboring blaTEM-168 gene by Etest | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | TEM-168, a heretofore laboratory-derived TEM beta-lactamase variant found in an Escherichia coli clinical isolate. |
| AID511389 | Antibacterial activity against Enterobacter cloacae by broth dilution method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Comparative in vitro activities of nemonoxacin (TG-873870), a novel nonfluorinated quinolone, and other quinolones against clinical isolates. |
| AID517951 | Antimicrobial activity against Providencia rettgeri by broth dilution method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli. |
| AID576271 | Antimicrobial activity against ESBL-positive Klebsiella pneumoniae 18567 harboring porin OmpK36V mutant gene by Etest | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | An ertapenem-resistant extended-spectrum-beta-lactamase-producing Klebsiella pneumoniae clone carries a novel OmpK36 porin variant. |
| AID531758 | Antibacterial activity against Pseudomonas aeruginosa 1956 harboring pNF225 carrying nfxB by twofold serial dilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Resistance and virulence of Pseudomonas aeruginosa clinical strains overproducing the MexCD-OprJ efflux pump. |
| AID532404 | Antibacterial activity against VIM-1 producing Pseudomonas aeruginosa clone F isolate RM-11X-09 by Etest method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | First countrywide survey of acquired metallo-beta-lactamases in gram-negative pathogens in Italy. |
| AID519007 | Antimicrobial activity against Escherichia coli HB101 expressing plasmid encoded TEM-149 T182M mutant by broth macrodilution method | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | E240V substitution increases catalytic efficiency toward ceftazidime in a new natural TEM-type extended-spectrum beta-lactamase, TEM-149, from Enterobacter aerogenes and Serratia marcescens clinical isolates. |
| AID499125 | Antimicrobial activity against Pseudomonas aeruginosa OC 4354 infected in immunocompromized SKH1 mouse assessed as lesion volume at 100 mg/kg/day, sc measured after 48 hrs postinfection (Rvb = 2195 mm3) | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vivo activity of ceftobiprole in murine skin infections due to Staphylococcus aureus and Pseudomonas aeruginosa. |
| AID529903 | Antimicrobial activity against Leptospira kirschneri serovar Grippotyphosa isolate 13 by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Antimicrobial susceptibilities of geographically diverse clinical human isolates of Leptospira. |
| AID285266 | Activity of Escherichia coli BL21(DE3) beta-lactamase TEM151 | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Evolution of TEM-type enzymes: biochemical and genetic characterization of two new complex mutant TEM enzymes, TEM-151 and TEM-152, from a single patient. |
| AID519006 | Antimicrobial activity against Escherichia coli HB101 harboring empty vector pBK-SK by broth macrodilution method | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | E240V substitution increases catalytic efficiency toward ceftazidime in a new natural TEM-type extended-spectrum beta-lactamase, TEM-149, from Enterobacter aerogenes and Serratia marcescens clinical isolates. |
| AID368323 | Antibacterial activity against Klebsiella oxytoca 4076 producing beta lactamase K1 by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID531604 | Activity of Escherichia coli Inhibitor-resistant beta-lactamase SHV-56 | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Molecular and biochemical characterization of SHV-56, a novel inhibitor-resistant beta-lactamase from Klebsiella pneumoniae. |
| AID558038 | Antimicrobial activity against blaKPC-positive Klebsiella pneumoniae S1 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Genetic organization of transposase regions surrounding blaKPC carbapenemase genes on plasmids from Klebsiella strains isolated in a New York City hospital. |
| AID535365 | Antimicrobial activity against Pseudomonas aeruginosa isolated from non-ICU patient by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activity of doripenem, a carbapenem for the treatment of challenging infections caused by gram-negative bacteria, against recent clinical isolates from the United States. |
| AID528846 | Antimicrobial activity against methicillin-resistant Staphylococcus epidermidis isolated from ICU patient urine assessed as resistant isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Antimicrobial-resistant pathogens in intensive care units in Canada: results of the Canadian National Intensive Care Unit (CAN-ICU) study, 2005-2006. |
| AID499148 | Tmax in immunocompromized SKH1 mouse plasma at 50 mg/kg, sc | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vivo activity of ceftobiprole in murine skin infections due to Staphylococcus aureus and Pseudomonas aeruginosa. |
| AID535718 | Activity of Escherichia coli TOP10 beta-lactamase AmpC-B2 S287N mutant | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Role of the Ser-287-Asn replacement in the hydrolysis spectrum extension of AmpC beta-lactamases in Escherichia coli. |
| AID521995 | Antimicrobial activity against Klebsiella pneumoniae isolate Kp3A expressing beta-lactamase OXA-48 by Etest method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Spread of OXA-48-encoding plasmid in Turkey and beyond. |
| AID554385 | Antimicrobial activity against Pseudomonas aeruginosa mutGR1 overexpressing mexXY mutant by twofold macrodilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Efflux unbalance in Pseudomonas aeruginosa isolates from cystic fibrosis patients. |
| AID368509 | Activity of Serratia marcescens SME3 assessed as drug hydrolysis by spectrophotometry | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID541516 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus clinical isolate after 18 to 22 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Establishment of in vitro susceptibility testing methodologies and comparative activities of piperacillin in combination with the penem {beta}-lactamase inhibitor BLI-489. |
| AID499072 | Antimicrobial activity against Citrobacter freundii RJ78 expressing CMY-2, qnrA1, aac(6')-Ib-cr, ompC by CLSI method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Phenotypic and genotypic characterization of Enterobacteriaceae with decreased susceptibility to carbapenems: results from large hospital-based surveillance studies in China. |
| AID573193 | Antimicrobial activity against mutS::lox,mexD::lox-deficient Pseudomonas aeruginosa PAOMSMxD biofilm by Etest method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Azithromycin in Pseudomonas aeruginosa biofilms: bactericidal activity and selection of nfxB mutants. |
| AID761216 | Antibacterial activity against Klebsiella pneumoniae 1000-02 by broth microdilution method | 2013 | Journal of medicinal chemistry, Jul-11, Volume: 56, Issue:13 | Pyridone-conjugated monobactam antibiotics with gram-negative activity. |
| AID519010 | Activity of Beta-lactamase TEM-149 T182M mutant expressed in Escherichia coli HB101 | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | E240V substitution increases catalytic efficiency toward ceftazidime in a new natural TEM-type extended-spectrum beta-lactamase, TEM-149, from Enterobacter aerogenes and Serratia marcescens clinical isolates. |
| AID535170 | Antimicrobial activity against imipenem susceptible Acinetobacter assessed as resistant isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activity of doripenem, a carbapenem for the treatment of challenging infections caused by gram-negative bacteria, against recent clinical isolates from the United States. |
| AID1079940 | Granulomatous liver disease, proven histopathologically. Value is number of references indexed. [column 'GRAN' in source] | |||
| AID498885 | Antimicrobial activity against Pseudomonas aeruginosa OC 4351 assessed as inhibition of growth by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vivo activity of ceftobiprole in murine skin infections due to Staphylococcus aureus and Pseudomonas aeruginosa. |
| AID540209 | Volume of distribution at steady state in human after iv administration | 2008 | Drug metabolism and disposition: the biological fate of chemicals, Jul, Volume: 36, Issue:7 | Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. |
| AID528521 | Antimicrobial activity against penicillin-resistant Streptococcus agalactiae ATCC BAA-611 by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | First molecular characterization of group B streptococci with reduced penicillin susceptibility. |
| AID576311 | Antimicrobial activity against ESBL-positive Klebsiella pneumoniae 29830 harboring porin OmpK36V mutant gene by Etest | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | An ertapenem-resistant extended-spectrum-beta-lactamase-producing Klebsiella pneumoniae clone carries a novel OmpK36 porin variant. |
| AID680847 | TP_TRANSPORTER: inhibition of Gly-Sar uptake (Gly-Sar: 50 uM, Cefepime: 2500uM) in PEPT1-expressing HeLa cells | 2000 | The Journal of biological chemistry, Jan-21, Volume: 275, Issue:3 | beta-lactam antibiotics as substrates for OCTN2, an organic cation/carnitine transporter. |
| AID532393 | Antibacterial activity against VIM-1 producing Pseudomonas aeruginosa clone A2 isolate NA-14X-26 by Etest method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | First countrywide survey of acquired metallo-beta-lactamases in gram-negative pathogens in Italy. |
| AID555222 | Antibacterial activity against Escherichia coli DH5alpha carrying ampC gene of Acinetobacter genomosp. 3 isolate 195 by Etest method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Genetic variability among ampC genes from acinetobacter genomic species 3. |
| AID499066 | Antimicrobial activity against carbapenem-resistant Enterobacter cloacae NJ88 deficient in CTX-M-14, ompC/F by CLSI method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Phenotypic and genotypic characterization of Enterobacteriaceae with decreased susceptibility to carbapenems: results from large hospital-based surveillance studies in China. |
| AID340738 | Ratio of Kcat to Km of Chryseobacterium indologenes metallo-beta-lactamase IND-5 expressed in Escherichia coli BL21(DE3) assessed as substrate hydrolysis relative to control | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8 | Identification and characterization of a new metallo-beta-lactamase, IND-5, from a clinical isolate of Chryseobacterium indologenes. |
| AID561630 | Antimicrobial activity against ampD1-, ampD2-deficient Stenotrophomonas maltophilia KJ by twofold serial agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | AmpDI is involved in expression of the chromosomal L1 and L2 beta-lactamases of Stenotrophomonas maltophilia. |
| AID368478 | Antibacterial activity against Enterobacter cloacae 4081 producing beta lactamase AmpC (E2) by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID511290 | Antibacterial activity against Escherichia coli DH5alpha | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | GES-13, a beta-lactamase variant possessing Lys-104 and Asn-170 in Pseudomonas aeruginosa. |
| AID560490 | Antibacterial activity against 5 x 10'5 CFU/ml Escherichia coli MC4100 harboring plasmid ACYC184 by microdilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Extended-spectrum properties of CMY-30, a Val211Gly mutant of CMY-2 cephalosporinase. |
| AID534299 | Antimicrobial activity against Pseudomonas aeruginosa isolate PA510 expressing VIM-2 beta-lactamase | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | First survey of metallo-beta-lactamases in clinical isolates of Pseudomonas aeruginosa in a German university hospital. |
| AID546429 | Activity at Pseudomonas aeruginosa PDC-5 by spectrophotometer | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Extended-spectrum cephalosporinases in Pseudomonas aeruginosa. |
| AID373035 | Antimicrobial activity against imipenem and meropenem-resistant Acinetobacter baumannii isolate BJ55 by CLSI agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Molecular epidemiology of clinical isolates of carbapenem-resistant Acinetobacter spp. from Chinese hospitals. |
| AID587532 | Antimicrobial activity against carbapenemases KPC-producing Klebsiella pneumoniae VA-406 infected in sc dosed CD-1 mouse in presence of 4 ug/ml cavulanate beta-lactamase inhibitor | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1 | Evaluation of ceftazidime and NXL104 in two murine models of infection due to KPC-producing Klebsiella pneumoniae. |
| AID517952 | Antimicrobial activity against Enterobacter cloacae by broth dilution method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli. |
| AID556652 | Antimicrobial activity against multidrug resistant Enterobacter aerogenes isolate 7 by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Occurrence of efflux mechanism and cephalosporinase variant in a population of Enterobacter aerogenes and Klebsiella pneumoniae isolates producing extended-spectrum beta-lactamases. |
| AID529647 | Antimicrobial activity against Escherichia coli DH5alpha harboring beta-lactamase VIM-15 by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | VIM-15 and VIM-16, two new VIM-2-like metallo-beta-lactamases in Pseudomonas aeruginosa isolates from Bulgaria and Germany. |
| AID563970 | Antibacterial activity against Escherichia coli J53 harboring beta-lactamase NDM-1 by Etest method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Characterization of a new metallo-beta-lactamase gene, bla(NDM-1), and a novel erythromycin esterase gene carried on a unique genetic structure in Klebsiella pneumoniae sequence type 14 from India. |
| AID1318923 | Antibacterial activity against multidrug/extremely drug-resistant/colistin-susceptible Pseudomonas aeruginosa isolate 264-104354 | 2016 | Journal of medicinal chemistry, 09-22, Volume: 59, Issue:18 | Hybrid Antibiotic Overcomes Resistance in P. aeruginosa by Enhancing Outer Membrane Penetration and Reducing Efflux. |
| AID394687 | Antibacterial activity against beta-lactams resistant Pseudomonas aeruginosa isolate expressing AmpC, MexXY-OprM pump by macrodilution technique | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10 | Pseudomonas aeruginosa may accumulate drug resistance mechanisms without losing its ability to cause bloodstream infections. |
| AID560059 | Antimicrobial activity against AmpC-depressed Enterobacter cloacae by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | In vitro activity of ceftaroline alone and in combination against clinical isolates of resistant gram-negative pathogens, including beta-lactamase-producing Enterobacteriaceae and Pseudomonas aeruginosa. |
| AID534608 | Antimicrobial activity against ceftazidime-susceptible Enterobacteriaceae assessed as intermediate isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activity of doripenem, a carbapenem for the treatment of challenging infections caused by gram-negative bacteria, against recent clinical isolates from the United States. |
| AID573375 | Antibacterial activity against multidrug-resistant Acinetobacter assessed as resistant isolates by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID528831 | Antimicrobial activity against CTX-M ESBL producing Escherichia coli isolated from ICU patient wound assessed as resistant isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Antimicrobial-resistant pathogens in intensive care units in Canada: results of the Canadian National Intensive Care Unit (CAN-ICU) study, 2005-2006. |
| AID535900 | Antimicrobial activity against aac(6')-Ib-cr-positive Citrobacter freundii JS33T harboring qnrA gene by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | High prevalence of plasmid-mediated quinolone resistance genes qnr and aac(6')-Ib-cr in clinical isolates of Enterobacteriaceae from nine teaching hospitals in China. |
| AID535135 | Antimicrobial activity against Ceftazidime susceptible Pseudomonas aeruginosa assessed as intermediate isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activity of doripenem, a carbapenem for the treatment of challenging infections caused by gram-negative bacteria, against recent clinical isolates from the United States. |
| AID342020 | Antibacterial activity against Escherichia coli J53 by Etest | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8 | Sequencing and comparative genomic analysis of pK29, a 269-kilobase conjugative plasmid encoding CMY-8 and CTX-M-3 beta-lactamases in Klebsiella pneumoniae. |
| AID531602 | Antimicrobial activity against Escherichia coli JM109 harboring pE1MD plasmid expressing beta-lactamase SHV-56 by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Molecular and biochemical characterization of SHV-56, a novel inhibitor-resistant beta-lactamase from Klebsiella pneumoniae. |
| AID532410 | Antibacterial activity against VIM-2 producing Pseudomonas aeruginosa clone B3 isolate CR-04X-14 by Etest method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | First countrywide survey of acquired metallo-beta-lactamases in gram-negative pathogens in Italy. |
| AID1559404 | Clearance in mouse at 190 mg/kg, iv after 1 to 6 hrs by LC-MS/MS analysis | 2020 | Journal of medicinal chemistry, 03-26, Volume: 63, Issue:6 | Discovery of Taniborbactam (VNRX-5133): A Broad-Spectrum Serine- and Metallo-β-lactamase Inhibitor for Carbapenem-Resistant Bacterial Infections. |
| AID556678 | Antimicrobial activity against multidrug resistant Klebsiella pneumoniae isolate 5 by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Occurrence of efflux mechanism and cephalosporinase variant in a population of Enterobacter aerogenes and Klebsiella pneumoniae isolates producing extended-spectrum beta-lactamases. |
| AID562775 | Antimicrobial activity against Escherichia coli DH10B by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | TEM-168, a heretofore laboratory-derived TEM beta-lactamase variant found in an Escherichia coli clinical isolate. |
| AID524750 | Antimicrobial activity against Escherichia coli MI1443 harboring V27A, Q38R, D240G mutations in beta lactamase CTX-M-15 by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Mutational events in cefotaximase extended-spectrum beta-lactamases of the CTX-M-1 cluster involved in ceftazidime resistance. |
| AID567743 | Antimicrobial activity against Pseudomonas aeruginosa OC 11678 expressing 36 fold elevated AmpC expression by broth macrodilution method | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | Differential selection of single-step AmpC or efflux mutants of Pseudomonas aeruginosa by using cefepime, ceftazidime, or ceftobiprole. |
| AID394488 | Activity of Hafnia alvei beta-lactamase ACC-1 assessed as nmol of compound hydrolysis per ug of protein | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10 | Plasmid-encoded ACC-4, an extended-spectrum cephalosporinase variant from Escherichia coli. |
| AID555202 | Antimicrobial activity against Pseudomonas aeruginosa PAO1 after 18 hrs by Etest | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Inactivation of the glycoside hydrolase NagZ attenuates antipseudomonal beta-lactam resistance in Pseudomonas aeruginosa. |
| AID572120 | Antimicrobial activity against Acinetobacter baumannii lambda clonal group isolate 27 expressing ampC, ompA, adeB, adeM, aadB, aadA1 by Etest method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Correlation of antimicrobial resistance with beta-lactamases, the OmpA-like porin, and efflux pumps in clinical isolates of Acinetobacter baumannii endemic to New York City. |
| AID525508 | Ratio of fAUC in Pseudomonas aeruginosa infected patient to MIC against Pseudomonas aeruginosa | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Clinical pharmacodynamics of cefepime in patients infected with Pseudomonas aeruginosa. |
| AID529893 | Antimicrobial activity against Leptospira interrogans serovar Bataviae isolate 1 by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Antimicrobial susceptibilities of geographically diverse clinical human isolates of Leptospira. |
| AID511583 | Antimicrobial activity against beta-lactam resistant Pseudomonas aeruginosa PAOD2 harboring oprD spontaneous mutant selected in vitro after antipseudomonal treatment of intensive care unit patient by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Activity of a new cephalosporin, CXA-101 (FR264205), against beta-lactam-resistant Pseudomonas aeruginosa mutants selected in vitro and after antipseudomonal treatment of intensive care unit patients. |
| AID535876 | Antimicrobial activity against aac(6')-Ib-cr-positive Citrobacter freundii JN1T by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | High prevalence of plasmid-mediated quinolone resistance genes qnr and aac(6')-Ib-cr in clinical isolates of Enterobacteriaceae from nine teaching hospitals in China. |
| AID1373323 | Antimicrobial activity against Escherichia coli expressing beta-lactamase Oxa-181 by CLSI broth microdilution method | 2018 | Bioorganic & medicinal chemistry letters, 02-15, Volume: 28, Issue:4 | Optimization of novel monobactams with activity against carbapenem-resistant Enterobacteriaceae - Identification of LYS228. |
| AID541814 | Antimicrobial activity against Enterococcus hirae clinical isolate after 18 to 22 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Establishment of in vitro susceptibility testing methodologies and comparative activities of piperacillin in combination with the penem {beta}-lactamase inhibitor BLI-489. |
| AID554399 | Antimicrobial activity against Pseudomonas aeruginosa isolate 2858 obtained from cystic fibrosis patient by disk diffusion method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Efflux unbalance in Pseudomonas aeruginosa isolates from cystic fibrosis patients. |
| AID554988 | Antibacterial activity against Acinetobacter genomosp. 3 isolate 56 by Etest method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Genetic variability among ampC genes from acinetobacter genomic species 3. |
| AID544953 | Antimicrobial activity against Escherichia coli expressing beta-lactamase CTX by Etest based on multiple determinants | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Characterization and sequence analysis of extended-spectrum-{beta}-lactamase-encoding genes from Escherichia coli, Klebsiella pneumoniae, and Proteus mirabilis isolates collected during tigecycline phase 3 clinical trials. |
| AID573196 | Antimicrobial activity against Pseudomonas aeruginosa PAO1 A biofilm harboring nfxB T248C mutant gene selected at 4 ug/ml of azithromycin after 4 passages by Etest method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Azithromycin in Pseudomonas aeruginosa biofilms: bactericidal activity and selection of nfxB mutants. |
| AID544952 | Antimicrobial activity against Escherichia coli expressing beta-lactamase CTX and SHV by Etest | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Characterization and sequence analysis of extended-spectrum-{beta}-lactamase-encoding genes from Escherichia coli, Klebsiella pneumoniae, and Proteus mirabilis isolates collected during tigecycline phase 3 clinical trials. |
| AID583653 | Antibacterial activity against Escherichia coli TOP10 | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Emergence of metallo-β-lactamase NDM-1-producing multidrug-resistant Escherichia coli in Australia. |
| AID534864 | Antimicrobial activity against Non-ESBL Proteus mirabilis assessed as susceptible isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activity of doripenem, a carbapenem for the treatment of challenging infections caused by gram-negative bacteria, against recent clinical isolates from the United States. |
| AID285256 | Antimicrobial activity against Escherichia coli DH5-alpha CF1295 isolate expressing CMT and TEM1 by disk diffusion assay | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Evolution of TEM-type enzymes: biochemical and genetic characterization of two new complex mutant TEM enzymes, TEM-151 and TEM-152, from a single patient. |
| AID522389 | Activity of Aeromonas caviae Beta-lactamase CAV1 | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Genetic and biochemical characterization of TRU-1, the endogenous class C beta-lactamase from Aeromonas enteropelogenes. |
| AID565724 | Antibacterial activity against oprD, mexB, mexY and mexD expressing Pseudomonas aeruginosa isolate Paebeta-29 harboring A residue at 105 position in PDC- 8 by Etest method in presence of cloxacillin | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Molecular epidemiology and mechanisms of carbapenem resistance in Pseudomonas aeruginosa. |
| AID528850 | Antimicrobial activity against methicillin-susceptible Staphylococcus epidermidis isolated from ICU patient wound assessed as resistant isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Antimicrobial-resistant pathogens in intensive care units in Canada: results of the Canadian National Intensive Care Unit (CAN-ICU) study, 2005-2006. |
| AID544918 | Antimicrobial activity against Providencia stuartii clinical isolate after 18 to 22 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Establishment of in vitro susceptibility testing methodologies and comparative activities of piperacillin in combination with the penem {beta}-lactamase inhibitor BLI-489. |
| AID498843 | Antimicrobial activity against carbapenem-resistant Klebsiella pneumoniae XJ81 deficient in TEM-1, SHV-12, DHA-1, aac(6')-Ib, ompK35/36 by CLSI method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Phenotypic and genotypic characterization of Enterobacteriaceae with decreased susceptibility to carbapenems: results from large hospital-based surveillance studies in China. |
| AID517963 | Antimicrobial activity against Pseudomonas aeruginosa by broth dilution method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli. |
| AID564022 | Antibacterial activity against Pseudomonas aeruginosa PAO1 harboring cloned pUCPOXA-161 by Etest | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Detection of the novel extended-spectrum beta-lactamase OXA-161 from a plasmid-located integron in Pseudomonas aeruginosa clinical isolates from Spain. |
| AID541528 | Antimicrobial activity against Staphylococcus haemolyticus clinical isolate after 18 to 22 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Establishment of in vitro susceptibility testing methodologies and comparative activities of piperacillin in combination with the penem {beta}-lactamase inhibitor BLI-489. |
| AID545658 | Antimicrobial activity against Acinetobacter sp. assessed as percent susceptible isolates by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Susceptibility of gram-negative pathogens isolated from patients with complicated intra-abdominal infections in the United States, 2007-2008: results of the Study for Monitoring Antimicrobial Resistance Trends (SMART). |
| AID544959 | Antimicrobial activity against Klebsiella pneumoniae expressing beta-lactamase SHV by Etest based on single determinant | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Characterization and sequence analysis of extended-spectrum-{beta}-lactamase-encoding genes from Escherichia coli, Klebsiella pneumoniae, and Proteus mirabilis isolates collected during tigecycline phase 3 clinical trials. |
| AID1079941 | Liver damage due to vascular disease: peliosis hepatitis, hepatic veno-occlusive disease, Budd-Chiari syndrome. Value is number of references indexed. [column 'VASC' in source] | |||
| AID498818 | Antimicrobial activity against Klebsiella pneumoniae GZ64 expressing IMP-4, ompK35/36 by CLSI method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Phenotypic and genotypic characterization of Enterobacteriaceae with decreased susceptibility to carbapenems: results from large hospital-based surveillance studies in China. |
| AID373034 | Antimicrobial activity against imipenem and meropenem-resistant Acinetobacter baumannii isolate BJ3-9 by CLSI agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Molecular epidemiology of clinical isolates of carbapenem-resistant Acinetobacter spp. from Chinese hospitals. |
| AID544954 | Antimicrobial activity against Escherichia coli extended-spectrum beta-lactamase producing isolate by Etest | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Characterization and sequence analysis of extended-spectrum-{beta}-lactamase-encoding genes from Escherichia coli, Klebsiella pneumoniae, and Proteus mirabilis isolates collected during tigecycline phase 3 clinical trials. |
| AID541498 | Antimicrobial activity against Stenotrophomonas maltophilia clinical isolate after 18 to 22 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Establishment of in vitro susceptibility testing methodologies and comparative activities of piperacillin in combination with the penem {beta}-lactamase inhibitor BLI-489. |
| AID341595 | Antibacterial activity against carbapenem-resistant Klebsiella pneumoniae 490 isolate producing KPC3 and TEM1 carbapenemases | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8 | Emergence of KPC-2 and KPC-3 in carbapenem-resistant Klebsiella pneumoniae strains in an Israeli hospital. |
| AID535127 | Antimicrobial activity against Ceftazidime susceptible Pseudomonas aeruginosa by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activity of doripenem, a carbapenem for the treatment of challenging infections caused by gram-negative bacteria, against recent clinical isolates from the United States. |
| AID285582 | Antimicrobial activity against Pseudomonas aeruginosa 65.33-1 tracheal isolates from mechanically ventilated tuberculosis patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID577649 | Antimicrobial activity against Escherichia coli isolate 329 expressing beta-lactamase KPC2, CTX-M-2, TEM and PFGE cluster 2 isolated from blood of patient by vitek-2 method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Carbapenem-resistant KPC-2-producing Escherichia coli in a Tel Aviv Medical Center, 2005 to 2008. |
| AID522023 | Antimicrobial activity against Citrobacter freundii isolate expressing beta-lactamase OXA-48 by Etest method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Spread of OXA-48-encoding plasmid in Turkey and beyond. |
| AID522379 | Antimicrobial activity against blaKPC-possessing Klebsiella pneumoniae isolates by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | In vitro activity of penem-1 in combination with beta-lactams against blaKPC-possessing Klebsiella pneumoniae isolates. |
| AID510503 | Antibacterial activity against Acinetobacter calcoaceticus/baumannii complex isolate M2AC9-31 expressing KPC beta lactamase | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Detection of KPC in Acinetobacter spp. in Puerto Rico. |
| AID557202 | Total clearance in critically ill patient with ventilator-associated pneumoniae at 2 g/kg administered as 3 hr infusion every 8 hrs by HPLC | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Population pharmacokinetics of high-dose, prolonged-infusion cefepime in adult critically ill patients with ventilator-associated pneumonia. |
| AID528977 | Antimicrobial activity against methicillin-susceptible Staphylococcus aureus isolated from ICU patient blood assessed as resistant isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Antimicrobial-resistant pathogens in intensive care units in Canada: results of the Canadian National Intensive Care Unit (CAN-ICU) study, 2005-2006. |
| AID558810 | Antimicrobial activity against Proteus mirabilis assessed as percent susceptible isolates by CLSI method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Emergence of high levels of extended-spectrum-beta-lactamase-producing gram-negative bacilli in the Asia-Pacific region: data from the Study for Monitoring Antimicrobial Resistance Trends (SMART) program, 2007. |
| AID534920 | Antimicrobial activity against Ceftazidime non-susceptible Serratia marcescens by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activity of doripenem, a carbapenem for the treatment of challenging infections caused by gram-negative bacteria, against recent clinical isolates from the United States. |
| AID534885 | Antimicrobial activity against Enterobacter cloacae with nonderepressed AmpC beta-lactamsae assessed as intermediate isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activity of doripenem, a carbapenem for the treatment of challenging infections caused by gram-negative bacteria, against recent clinical isolates from the United States. |
| AID544949 | Antimicrobial activity against Escherichia coli expressing beta-lactamase AmpC and extended-spectrum beta-lactamase by Etest | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Characterization and sequence analysis of extended-spectrum-{beta}-lactamase-encoding genes from Escherichia coli, Klebsiella pneumoniae, and Proteus mirabilis isolates collected during tigecycline phase 3 clinical trials. |
| AID508490 | Antimicrobial activity against Pseudomonas aeruginosa isolate K45-32 producing metallo-beta-lactamase VIM2 by Etest | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Molecular epidemiology of metallo-beta-lactamase-producing Pseudomonas aeruginosa isolates from Norway and Sweden shows import of international clones and local clonal expansion. |
| AID555556 | Antimicrobial activity against Pseudomonas aeruginosa isolate 22843 expressing VIM-2 beta lactamase gene by Etest | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | First organisms with acquired metallo-beta-lactamases (IMP-13, IMP-22, and VIM-2) reported in Austria. |
| AID301086 | Antibacterial activity against Pseudomonas aeruginosa SR-5393 after 20 hrs by agar dilution method | 2007 | Bioorganic & medicinal chemistry, Nov-01, Volume: 15, Issue:21 | A novel series of parenteral cephalosporins exhibiting potent activities against Pseudomonas aeruginosa and other Gram-negative pathogens: synthesis and structure-activity relationships. |
| AID543431 | Activity at Shigella sonnei UIH-1 beta-lactamase CTX-M-64 by spectrophotometry | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Novel chimeric beta-lactamase CTX-M-64, a hybrid of CTX-M-15-like and CTX-M-14 beta-lactamases, found in a Shigella sonnei strain resistant to various oxyimino-cephalosporins, including ceftazidime. |
| AID522569 | Antimicrobial activity against Escherichia coli isolate 5000869 with AmpC beta-lactamase H296P mutation | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Occurrence of ST23 complex phylogroup A Escherichia coli isolates producing extended-spectrum AmpC beta-lactamase in a French hospital. |
| AID522187 | Antimicrobial activity against Klebsiella pneumoniae isolate KpL expressing beta-lactamase OXA-48 by Etest method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Spread of OXA-48-encoding plasmid in Turkey and beyond. |
| AID534304 | Antimicrobial activity against metallo-beta-lactamase-negative Pseudomonas aeruginosa isolate PA494 | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | First survey of metallo-beta-lactamases in clinical isolates of Pseudomonas aeruginosa in a German university hospital. |
| AID546163 | Antimicrobial activity against AmpC overproducing Pseudomonas aeruginosa isolate Pae-beta-03 with PDC-2 variant by Etest | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Extended-spectrum cephalosporinases in Pseudomonas aeruginosa. |
| AID560058 | Antimicrobial activity against ESBL-producing Klebsiella pneumoniae by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | In vitro activity of ceftaroline alone and in combination against clinical isolates of resistant gram-negative pathogens, including beta-lactamase-producing Enterobacteriaceae and Pseudomonas aeruginosa. |
| AID394688 | Antibacterial activity against beta-lactams resistant OprD-deficient Pseudomonas aeruginosa isolate by macrodilution technique | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10 | Pseudomonas aeruginosa may accumulate drug resistance mechanisms without losing its ability to cause bloodstream infections. |
| AID573361 | Antibacterial activity against ceftazidime-nonsusceptible Klebsiella pneumoniae by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID285583 | Antimicrobial activity against Pseudomonas aeruginosa 65.33-2 tracheal isolates from mechanically ventilated tuberculosis patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID532184 | Antimicrobial activity against aac(6')-Ib-cr-positive Klebsiella pneumoniae SY26 harboring GyrA S83I, ParC S80I mutant, wild-type GyrB and qnrB genes by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | High prevalence of plasmid-mediated quinolone resistance genes qnr and aac(6')-Ib-cr in clinical isolates of Enterobacteriaceae from nine teaching hospitals in China. |
| AID509866 | Antibacterial activity against Acinetobacter baumannii isolate 510 isolated from human sputum | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Acinetobacter baumannii increases tolerance to antibiotics in response to monovalent cations. |
| AID1318933 | Antibacterial activity against multidrug-resistant/tobramycin-susceptible Pseudomonas aeruginosa isolate 79199 | 2016 | Journal of medicinal chemistry, 09-22, Volume: 59, Issue:18 | Hybrid Antibiotic Overcomes Resistance in P. aeruginosa by Enhancing Outer Membrane Penetration and Reducing Efflux. |
| AID535657 | Antimicrobial activity against aac(6')-Ib-cr-negative Enterobacter cloacae FJ61T harboring qnrS gene by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | High prevalence of plasmid-mediated quinolone resistance genes qnr and aac(6')-Ib-cr in clinical isolates of Enterobacteriaceae from nine teaching hospitals in China. |
| AID558044 | Antimicrobial activity against blaKPC-positive Klebsiella pneumoniae S7 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Genetic organization of transposase regions surrounding blaKPC carbapenemase genes on plasmids from Klebsiella strains isolated in a New York City hospital. |
| AID544962 | Antimicrobial activity against Klebsiella pneumoniae expressing beta-lactamase SHV and CTX by Etest | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Characterization and sequence analysis of extended-spectrum-{beta}-lactamase-encoding genes from Escherichia coli, Klebsiella pneumoniae, and Proteus mirabilis isolates collected during tigecycline phase 3 clinical trials. |
| AID573373 | Antibacterial activity against multidrug-resistant Acinetobacter by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID564462 | Antimicrobial activity against Pseudomonas aeruginosa isolate 913 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | In vivo efficacy of 1- and 2-gram human simulated prolonged infusions of doripenem against Pseudomonas aeruginosa. |
| AID572140 | Antimicrobial activity against Acinetobacter baumannii unique clonal group isolate 37 expressing ampC, ompA, adeB, adeM by Etest method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Correlation of antimicrobial resistance with beta-lactamases, the OmpA-like porin, and efflux pumps in clinical isolates of Acinetobacter baumannii endemic to New York City. |
| AID584563 | Antimicrobial activity against Acinetobacter lwoffii isolate J expressing beta-lactamase OXA-58 isolated from bedsore by vitek 2 system | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | In vivo selection of a missense mutation in adeR and conversion of the novel blaOXA-164 gene into blaOXA-58 in carbapenem-resistant Acinetobacter baumannii isolates from a hospitalized patient. |
| AID587733 | Ratio of Kcat to Km for Pseudomonas aeruginosa strain PS 297 metallo-beta-lactamase IMP-1 expressed in Escherichia coli BL21(DE3) assessed as substrate hydrolysis using 100 uM nitrocefin | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1 | Genetic context and biochemical characterization of the IMP-18 metallo-beta-lactamase identified in a Pseudomonas aeruginosa isolate from the United States. |
| AID583027 | Antimicrobial activity against Escherichia coli TOP10 transformed with Escherichia coli ECB-1 plasmid carrying ACC-1 by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Phenotypic and biochemical comparison of the carbapenem-hydrolyzing activities of five plasmid-borne AmpC β-lactamases. |
| AID554429 | Ratio of MIC for Pseudomonas aeruginosa FE60 transformed with pAGH97 carrying mexXY operon to Pseudomonas aeruginosa PAO1 | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Efflux unbalance in Pseudomonas aeruginosa isolates from cystic fibrosis patients. |
| AID556651 | Antimicrobial activity against multidrug resistant Enterobacter aerogenes isolate 6 by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Occurrence of efflux mechanism and cephalosporinase variant in a population of Enterobacter aerogenes and Klebsiella pneumoniae isolates producing extended-spectrum beta-lactamases. |
| AID561675 | Antimicrobial activity against Pseudomonas aeruginosa isolate OC17355 harboring plasmid JAK16 expressing mexXY gene by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Effect of MexXY overexpression on ceftobiprole susceptibility in Pseudomonas aeruginosa. |
| AID394493 | Antimicrobial activity against Escherichia coli MC4100 harboring pA-acc1 plasmid by agar dilution technique | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10 | Plasmid-encoded ACC-4, an extended-spectrum cephalosporinase variant from Escherichia coli. |
| AID576293 | Antimicrobial activity against ESBL-positive Klebsiella pneumoniae 11932 harboring porin OmpK36 gene by Etest | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | An ertapenem-resistant extended-spectrum-beta-lactamase-producing Klebsiella pneumoniae clone carries a novel OmpK36 porin variant. |
| AID534884 | Antimicrobial activity against Enterobacter cloacae with nonderepressed AmpC beta-lactamsae assessed as susceptible isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activity of doripenem, a carbapenem for the treatment of challenging infections caused by gram-negative bacteria, against recent clinical isolates from the United States. |
| AID573392 | Antibacterial activity against ceftazidime-susceptible Providencia sp. assessed as susceptible isolates by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID529576 | Ratio of Kcat to Km for Erwinia carotovora subsp. atroseptica DSM 30184 beta-Lactamase CAR-1 | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Functional diversity among metallo-beta-lactamases: characterization of the CAR-1 enzyme of Erwinia carotovora. |
| AID1592957 | Antibacterial activity against multi-drug resistant Escherichia coli NMI 3548/14 assessed as reduction in microbial growth incubated for 20 hrs | 2019 | European journal of medicinal chemistry, Apr-15, Volume: 168 | Microwave-assisted solid-phase synthesis of antisense acpP peptide nucleic acid-peptide conjugates active against colistin- and tigecycline-resistant E. coli and K. pneumoniae. |
| AID565530 | Antibacterial activity against oprD, mexB, mexY and mexD expressing Pseudomonas aeruginosa isolate Paebeta-05 harboring A residue at 105 position in PDC- 2 by Etest method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Molecular epidemiology and mechanisms of carbapenem resistance in Pseudomonas aeruginosa. |
| AID495663 | Activity at Pseudomonas aeruginosa 51170 beta-lactamase BEL-1 | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | BEL-2, an extended-spectrum beta-lactamase with increased activity toward expanded-spectrum cephalosporins in Pseudomonas aeruginosa. |
| AID1373314 | Antimicrobial activity against Escherichia coli expressing beta-lactamase P99 by CLSI broth microdilution method | 2018 | Bioorganic & medicinal chemistry letters, 02-15, Volume: 28, Issue:4 | Optimization of novel monobactams with activity against carbapenem-resistant Enterobacteriaceae - Identification of LYS228. |
| AID543423 | Antimicrobial activity against Escherichia coli XL-1 Blue transconjugant harboring beta-lactamase CTX-M-64 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Novel chimeric beta-lactamase CTX-M-64, a hybrid of CTX-M-15-like and CTX-M-14 beta-lactamases, found in a Shigella sonnei strain resistant to various oxyimino-cephalosporins, including ceftazidime. |
| AID1139546 | Antibacterial activity against Escherichia coli DH5alpha expressing beta-lactamase OXA-58 by CLSI broth microdilution method | 2014 | Journal of medicinal chemistry, May-08, Volume: 57, Issue:9 | Siderophore receptor-mediated uptake of lactivicin analogues in gram-negative bacteria. |
| AID511578 | Antimicrobial activity against beta-lactam resistant Pseudomonas aeruginosa PAO1 deficient in ampD gene selected in vitro after antipseudomonal treatment of intensive care unit patient by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Activity of a new cephalosporin, CXA-101 (FR264205), against beta-lactam-resistant Pseudomonas aeruginosa mutants selected in vitro and after antipseudomonal treatment of intensive care unit patients. |
| AID573379 | Antibacterial activity against beta lactamase-negative Haemophilus influenzae by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID1139542 | Antibacterial activity against Escherichia coli DH5alpha expressing beta-lactamase CTX-M-15 by CLSI broth microdilution method | 2014 | Journal of medicinal chemistry, May-08, Volume: 57, Issue:9 | Siderophore receptor-mediated uptake of lactivicin analogues in gram-negative bacteria. |
| AID323037 | Antimicrobial activity against extended-spectrum-beta-lactamase producing Escherichia coli isolates | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Predictors of mortality in patients with bloodstream infections caused by extended-spectrum-beta-lactamase-producing Enterobacteriaceae: importance of inadequate initial antimicrobial treatment. |
| AID1604441 | Antibacterial activity against Klebsiella pneumoniae by CLSI based microdilution method | 2020 | Journal of medicinal chemistry, 03-12, Volume: 63, Issue:5 | β-Lactamase Inhibitors To Restore the Efficacy of Antibiotics against Superbugs. |
| AID557201 | Volume of distribution in critically ill patient with ventilator-associated pneumoniae at 2 g/kg administered as 3 hr infusion every 8 hrs by HPLC | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Population pharmacokinetics of high-dose, prolonged-infusion cefepime in adult critically ill patients with ventilator-associated pneumonia. |
| AID571906 | Antimicrobial activity against ISAba1 linked with the blaOXA-51-type beta-lactamase harboring Acinetobacter baumannii beta clonal group isolate 17 expressing ompA, adeB, adeM, aacA4, blaSHV-5 by Etest method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Correlation of antimicrobial resistance with beta-lactamases, the OmpA-like porin, and efflux pumps in clinical isolates of Acinetobacter baumannii endemic to New York City. |
| AID573339 | Antibacterial activity against ceftazidime-nonsusceptible Enterobacteriaceae assessed as resistant isolates by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID522573 | Antimicrobial activity against Escherichia coli isolate 8009162 with AmpC beta-lactamase A292V mutation | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Occurrence of ST23 complex phylogroup A Escherichia coli isolates producing extended-spectrum AmpC beta-lactamase in a French hospital. |
| AID530350 | Antimicrobial activity against Escherichia coli TOP10 by disk diffusion method | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Plasmid-mediated quinolone resistance pump QepA2 in an Escherichia coli isolate from France. |
| AID531753 | Antibacterial activity against Pseudomonas aeruginosa 2439 by twofold serial dilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Resistance and virulence of Pseudomonas aeruginosa clinical strains overproducing the MexCD-OprJ efflux pump. |
| AID554400 | Antimicrobial activity against Pseudomonas aeruginosa isolate 2933 obtained from cystic fibrosis patient by disk diffusion method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Efflux unbalance in Pseudomonas aeruginosa isolates from cystic fibrosis patients. |
| AID368540 | Activity of Pseudomonas aeruginosa 4352 AmpC assessed as drug hydrolysis by spectrophotometry relative to cephaloridine | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID519178 | Antimicrobial activity against MexXY-OprM-overproducing Pseudomonas aeruginosa PAO1 harboring MexY agrZ mutant and MexZ mutant gene selected after 1 ug/ml of tobramycin exposure | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Relationship between antibiotic use and incidence of MexXY-OprM overproducers among clinical isolates of Pseudomonas aeruginosa. |
| AID285596 | Antimicrobial activity against Pseudomonas aeruginosa 1C9 tracheal isolates from mechanically ventilated tuberculosis patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID368487 | Antibacterial activity against Pseudomonas aeruginosa 4083 producing beta lactamase OXA10 by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID544933 | Antimicrobial activity against Acinetobacter junii clinical isolate after 18 to 22 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Establishment of in vitro susceptibility testing methodologies and comparative activities of piperacillin in combination with the penem {beta}-lactamase inhibitor BLI-489. |
| AID535702 | Antibacterial activity against Escherichia coli TOP10 expressing AmpC-A by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Role of the Ser-287-Asn replacement in the hydrolysis spectrum extension of AmpC beta-lactamases in Escherichia coli. |
| AID521345 | Antimicrobial activity against Streptococcus pneumoniae isolate k-637 obtained from CSF of patient | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Highly variable penicillin resistance determinants PBP 2x, PBP 2b, and PBP 1a in isolates of two Streptococcus pneumoniae clonal groups, Poland 23F-16 and Poland 6B-20. |
| AID546416 | Antimicrobial activity against Pseudomonas aeruginosa KG2505a harboring recombinant pBB-PDC-1b by Etest | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Extended-spectrum cephalosporinases in Pseudomonas aeruginosa. |
| AID567751 | Antimicrobial activity against Pseudomonas aeruginosa OC 12070 expressing 37 fold elevated AmpC expression by broth macrodilution method | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | Differential selection of single-step AmpC or efflux mutants of Pseudomonas aeruginosa by using cefepime, ceftazidime, or ceftobiprole. |
| AID557797 | Antimicrobial activity against Escherichia coli J53 transconjugated with Proteus mirabilis pHS10 carrying qnrC gene by CLSI agar dilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | New plasmid-mediated quinolone resistance gene, qnrC, found in a clinical isolate of Proteus mirabilis. |
| AID283537 | Antibacterial activity against Pseudomonas aeruginosa FE57U with inactivated rplY and galU genes by microdilution method | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3 | Cumulative effects of several nonenzymatic mechanisms on the resistance of Pseudomonas aeruginosa to aminoglycosides. |
| AID555221 | Antibacterial activity against Escherichia coli DH5alpha carrying ampC gene of Acinetobacter genomosp. 3 isolate 109 by Etest method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Genetic variability among ampC genes from acinetobacter genomic species 3. |
| AID283549 | Antibacterial activity against Pseudomonas aeruginosa FE64 containing inactivated rplY and mexXY genes by microdilution method | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3 | Cumulative effects of several nonenzymatic mechanisms on the resistance of Pseudomonas aeruginosa to aminoglycosides. |
| AID529578 | Ratio of Kcat to Km for Chryseobacterium meningosepticum beta-Lactamase GOB-1 | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Functional diversity among metallo-beta-lactamases: characterization of the CAR-1 enzyme of Erwinia carotovora. |
| AID564016 | Antibacterial activity against Pseudomonas aeruginosa PAO1 harboring Pseudomonas aeruginosa plasmid DNA isolated from wound infection of patient by Etest | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Detection of the novel extended-spectrum beta-lactamase OXA-161 from a plasmid-located integron in Pseudomonas aeruginosa clinical isolates from Spain. |
| AID373027 | Antimicrobial activity against imipenem and meropenem-resistant Acinetobacter baumannii isolate PUA6 by CLSI agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Molecular epidemiology of clinical isolates of carbapenem-resistant Acinetobacter spp. from Chinese hospitals. |
| AID544822 | Antimicrobial activity against Pseudomonas aeruginosa Xen 5 biofilm assessed as log10 CFU/cm'2 in bacterial count in presence of 2000 microamperes of electric current by bioelectric effect assay | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Effect of electrical current on the activities of antimicrobial agents against Pseudomonas aeruginosa, Staphylococcus aureus, and Staphylococcus epidermidis biofilms. |
| AID444055 | Fraction absorbed in human | 2010 | Journal of medicinal chemistry, Feb-11, Volume: 53, Issue:3 | Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. |
| AID495806 | Antimicrobial activity against Providencia stuartii 6858 strain expressing beta-lactamase VIM-19 by microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Novel VIM metallo-beta-lactamase variant from clinical isolates of Enterobacteriaceae from Algeria. |
| AID564533 | Antimicrobial activity against Escherichia coli TOP10 harboring pADC-11 plasmid carrying entire blaAmpC gene with alanine residue insertion at 215 position by Etest method | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | Extended-spectrum cephalosporinase in Acinetobacter baumannii. |
| AID394497 | Antimicrobial activity against Escherichia coli MC4100 harboring pBCSK plasmid by agar dilution technique | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10 | Plasmid-encoded ACC-4, an extended-spectrum cephalosporinase variant from Escherichia coli. |
| AID283321 | Antimicrobial activity against Escherichia coli XL10/vector | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3 | Detection of a new SHV-type extended-spectrum beta-lactamase, SHV-31, in a Klebsiella pneumoniae strain causing a large nosocomial outbreak in The Netherlands. |
| AID524741 | Antimicrobial activity against beta lactamase CTX-M-10 producing Escherichia coli GB20 by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Mutational events in cefotaximase extended-spectrum beta-lactamases of the CTX-M-1 cluster involved in ceftazidime resistance. |
| AID573393 | Antibacterial activity against ceftazidime-susceptible Providencia sp. assessed as resistant isolates by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID496009 | Antimicrobial activity against tobramycin resistant Pseudomonas aeruginosa isolates by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vitro potency of CXA-101, a novel cephalosporin, against Pseudomonas aeruginosa displaying various resistance phenotypes, including multidrug resistance. |
| AID519638 | Antimicrobial activity against ceftazidime-resistant Escherichia coli Irk2320 harboring beta-lactamase CTX-M-42 Pro167Thr mutant gene by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Convergent in vivo and in vitro selection of ceftazidime resistance mutations at position 167 of CTX-M-3 beta-lactamase in hypermutable Escherichia coli strains. |
| AID529194 | Antibacterial activity against AmpC-producing Escherichia coli isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Comparison of antimicrobial resistance profiles among extended-spectrum-beta-lactamase-producing and acquired AmpC beta-lactamase-producing Escherichia coli isolates from Canadian intensive care units. |
| AID529460 | Antimicrobial activity against Escherichia coli J53 harboring beta-lactamase TEM-1, SHV-12 and Oxa-9 by Etest | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Spread of OXA-48-positive carbapenem-resistant Klebsiella pneumoniae isolates in Istanbul, Turkey. |
| AID518816 | Antibacterial activity against Acinetobacter genomosp. 3 isolates by broth micro dilution | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Molecular characterization of beta-lactamase genes and their genetic structures in Acinetobacter genospecies 3 isolates in Taiwan. |
| AID535639 | Antimicrobial activity against Group B streptococcus serotype VI R1 harboring F395L, V405A, R433H, H438Y, and G648A mutations in PBP 2X and T567I mutation in PBP 2B by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | Genetic heterogeneity in pbp genes among clinically isolated group B Streptococci with reduced penicillin susceptibility. |
| AID544683 | Antimicrobial activity against Enterobacter aerogenes clinical isolate after 18 to 22 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Establishment of in vitro susceptibility testing methodologies and comparative activities of piperacillin in combination with the penem {beta}-lactamase inhibitor BLI-489. |
| AID285655 | Antimicrobial activity against Pseudomonas aeruginosa 19D10 tracheal isolates from mechanically ventilated chronic respiratory insufficiency patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID535757 | Antimicrobial activity against community-acquired Escherichia coli expressing extended spectrum beta-lactamase obtained from patient with intra-abdominal infection assessed as susceptible isolates by EUCAST method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Incidence and antimicrobial susceptibility of Escherichia coli and Klebsiella pneumoniae with extended-spectrum beta-lactamases in community- and hospital-associated intra-abdominal infections in Europe: results of the 2008 Study for Monitoring Antimicrob |
| AID518726 | Antimicrobial activity against Escherichia coli TOP10 by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Characterization of DIM-1, an integron-encoded metallo-beta-lactamase from a Pseudomonas stutzeri clinical isolate in the Netherlands. |
| AID587526 | Antimicrobial activity against carbapenemases KPC-producing Klebsiella pneumoniae VA-361 infected in sc dosed CD-1 mouse in presence of 4 ug/ml cavulanate beta-lactamase inhibitor | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1 | Evaluation of ceftazidime and NXL104 in two murine models of infection due to KPC-producing Klebsiella pneumoniae. |
| AID368489 | Activity of Klebsiella pneumoniae SHV1 assessed as drug hydrolysis by spectrophotometry relative to cephaloridine | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID521838 | Antibacterial activity against Klebsiella pneumoniae isolate VA375 with blaKPC-3, qnrA1, blaTEM-1, blaSHV-11 genes by CLSI method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Presence of plasmid-mediated quinolone resistance in Klebsiella pneumoniae isolates possessing blaKPC in the United States. |
| AID499073 | Antimicrobial activity against carbapenem-resistant Enterobacter cloacae SZ93 deficient in ompC by CLSI method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Phenotypic and genotypic characterization of Enterobacteriaceae with decreased susceptibility to carbapenems: results from large hospital-based surveillance studies in China. |
| AID495914 | Hydrolytic activity of beta-lactamase VIM-1 expressed in Escherichia coli TOP10 by spectrophotometry | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | VIM-19, a metallo-beta-lactamase with increased carbapenemase activity from Escherichia coli and Klebsiella pneumoniae. |
| AID285646 | Antimicrobial activity against Pseudomonas aeruginosa 16D5 tracheal isolates from mechanically ventilated chronic respiratory insufficiency patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID520809 | Antimicrobial activity against CTX-M-59 and TEM-1 producing Klebsiella pneumoniae transconjugants/transformants with PFGE pulsotype C by Etest | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Multiclonal outbreak of Klebsiella pneumoniae producing extended-spectrum beta-lactamase CTX-M-2 and novel variant CTX-M-59 in a neonatal intensive care unit in Brazil. |
| AID544531 | Antimicrobial activity against Escherichia coli DH5[alpha] isolate GC 7668 expressing bla SHV-48 gene by microdilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Pyrosequencing using the single-nucleotide polymorphism protocol for rapid determination of TEM- and SHV-type extended-spectrum beta-lactamases in clinical isolates and identification of the novel beta-lactamase genes blaSHV-48, blaSHV-105, and blaTEM-155 |
| AID558048 | Antimicrobial activity against blaKPC-positive Klebsiella pneumoniae S11 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Genetic organization of transposase regions surrounding blaKPC carbapenemase genes on plasmids from Klebsiella strains isolated in a New York City hospital. |
| AID285259 | Antimicrobial activity against recombinant Escherichia coli DH5-alpha isolate expressing pBK-TEM-29 and ESBL by disk diffusion assay | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Evolution of TEM-type enzymes: biochemical and genetic characterization of two new complex mutant TEM enzymes, TEM-151 and TEM-152, from a single patient. |
| AID301089 | Antibacterial activity against penicillin resistant Streptococcus pneumoniae SR-16675 after 20 hrs by agar dilution method | 2007 | Bioorganic & medicinal chemistry, Nov-01, Volume: 15, Issue:21 | A novel series of parenteral cephalosporins exhibiting potent activities against Pseudomonas aeruginosa and other Gram-negative pathogens: synthesis and structure-activity relationships. |
| AID285513 | Antibacterial activity against Klebsiella pneumoniae | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | In vitro and in vivo antibacterial activities of heteroaryl isothiazolones against resistant gram-positive pathogens. |
| AID1373289 | Antimicrobial activity against Escherichia coli expressing beta-lactamase NMC-A by CLSI broth microdilution method | 2018 | Bioorganic & medicinal chemistry letters, 02-15, Volume: 28, Issue:4 | Optimization of novel monobactams with activity against carbapenem-resistant Enterobacteriaceae - Identification of LYS228. |
| AID554985 | Antibacterial activity against Acinetobacter genomosp. 3 isolate 20 by Etest method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Genetic variability among ampC genes from acinetobacter genomic species 3. |
| AID542061 | Antibacterial activity against Klebsiella pneumoniae A expressing CTX-M group 1 beta-lactamase by Etest method in presence of clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Nationwide survey of CTX-M-type extended-spectrum beta-lactamases among Klebsiella pneumoniae isolates in Slovenian hospitals. |
| AID368501 | Activity of Klebsiella pneumoniae TEM26 assessed as drug hydrolysis by spectrophotometry | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID1143121 | Antibacterial activity against Klebsiella pneumoniae KPC2 ST258 assessed as inhibition of visible growth after 18 hrs incubation by standard broth dilution method | 2014 | Journal of medicinal chemistry, May-22, Volume: 57, Issue:10 | New Ianthelliformisamine derivatives as antibiotic enhancers against resistant Gram-negative bacteria. |
| AID522017 | Antimicrobial activity against Providencia rettgeri isolate expressing beta-lactamase OXA-48 and TEM-101 by Etest method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Spread of OXA-48-encoding plasmid in Turkey and beyond. |
| AID520968 | Antibacterial activity against Escherichia coli harboring pRYC plasmid expressing blaKPC gene by Etest method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Genetic structures at the origin of acquisition of the beta-lactamase bla KPC gene. |
| AID532396 | Antibacterial activity against VIM-1 producing Pseudomonas aeruginosa clone A3 isolate FG-17X-08 by Etest method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | First countrywide survey of acquired metallo-beta-lactamases in gram-negative pathogens in Italy. |
| AID560077 | Antimicrobial activity against Pseudomonas aeruginosa isolate 796 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | In vitro activity of ceftaroline alone and in combination against clinical isolates of resistant gram-negative pathogens, including beta-lactamase-producing Enterobacteriaceae and Pseudomonas aeruginosa. |
| AID535632 | Antimicrobial activity against Group B streptococcus R8 harboring T77I, S353F and A514V in PBP 2X; V80A and G613R in PBP 2B; and L45P, N163K, N723S and G527V in PBP 1A by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | Genetic heterogeneity in pbp genes among clinically isolated group B Streptococci with reduced penicillin susceptibility. |
| AID323042 | Antimicrobial activity against extended-spectrum-beta-lactamase producing Proteus mirabilis assessed as percent resistant isolates | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Predictors of mortality in patients with bloodstream infections caused by extended-spectrum-beta-lactamase-producing Enterobacteriaceae: importance of inadequate initial antimicrobial treatment. |
| AID583641 | Cmin in febrile neutropenic patient with GFR of <40 ml/min at 2 g administered as 30 mins infusion every 8 hrs measured after 4 days by HPLC analysis | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | High cefepime plasma concentrations and neurological toxicity in febrile neutropenic patients with mild impairment of renal function. |
| AID498883 | Antimicrobial activity against methicillin-susceptible Staphylococcus aureus OC 4172 assessed as inhibition of growth by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vivo activity of ceftobiprole in murine skin infections due to Staphylococcus aureus and Pseudomonas aeruginosa. |
| AID587527 | Antimicrobial activity against carbapenemases KPC-producing Klebsiella pneumoniae VA-361 infected in sc dosed CD-1 mouse | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1 | Evaluation of ceftazidime and NXL104 in two murine models of infection due to KPC-producing Klebsiella pneumoniae. |
| AID535879 | Antimicrobial activity against aac(6')-Ib-cr-positive Klebsiella pneumoniae JN132 harboring GyrA S83I, ParC S80I mutant, wild-type GyrB and qnrB genes by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | High prevalence of plasmid-mediated quinolone resistance genes qnr and aac(6')-Ib-cr in clinical isolates of Enterobacteriaceae from nine teaching hospitals in China. |
| AID577647 | Antimicrobial activity against Escherichia coli isolate 157 expressing beta-lactamase KPC2, CTX-M-15, TEM and PFGE cluster 3 isolated from urine of patient by vitek-2 method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Carbapenem-resistant KPC-2-producing Escherichia coli in a Tel Aviv Medical Center, 2005 to 2008. |
| AID368482 | Antibacterial activity against Providencia stuartii 2772 producing beta lactamase AmpC by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID535719 | Ratio of Kcat to Km for Escherichia coli TOP10 beta-lactamase AmpC-B2 S287N mutant | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Role of the Ser-287-Asn replacement in the hydrolysis spectrum extension of AmpC beta-lactamases in Escherichia coli. |
| AID556681 | Antimicrobial activity against multidrug resistant Klebsiella pneumoniae isolate 8 by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Occurrence of efflux mechanism and cephalosporinase variant in a population of Enterobacter aerogenes and Klebsiella pneumoniae isolates producing extended-spectrum beta-lactamases. |
| AID1373316 | Antimicrobial activity against Escherichia coli expressing beta-lactamase Oxa-18 by CLSI broth microdilution method | 2018 | Bioorganic & medicinal chemistry letters, 02-15, Volume: 28, Issue:4 | Optimization of novel monobactams with activity against carbapenem-resistant Enterobacteriaceae - Identification of LYS228. |
| AID573391 | Antibacterial activity against ceftazidime-susceptible Providencia sp. by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID522016 | Antimicrobial activity against Escherichia coli isolate J53 harboring pL containing beta-lactamase OXA-48 located within transposon Tn1999.2 by Etest method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Spread of OXA-48-encoding plasmid in Turkey and beyond. |
| AID560065 | Antimicrobial activity against Escherichia coli isolate 5401 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | In vitro activity of ceftaroline alone and in combination against clinical isolates of resistant gram-negative pathogens, including beta-lactamase-producing Enterobacteriaceae and Pseudomonas aeruginosa. |
| AID520977 | Antibacterial activity against Escherichia coli DH10B expressing blaKPC gene by Etest method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Genetic structures at the origin of acquisition of the beta-lactamase bla KPC gene. |
| AID546182 | Antimicrobial activity against AmpC overproducing Pseudomonas aeruginosa isolate Pae-beta-22 with PDC-4 variant by Etest | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Extended-spectrum cephalosporinases in Pseudomonas aeruginosa. |
| AID560555 | Antimicrobial activity against Proteus vulgaris Pv7 expressing beta-lactamase PER-1 by disk diffusion method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Emergence of extended-spectrum beta-lactamase PER-1 in Proteus vulgaris and Providencia stuartii isolates from Algiers, Algeria. |
| AID368522 | Ratio of Kcat to Km of Enterobacter cloacae 4092 AmpC (E2) assessed as drug hydrolysis by spectrophotometry relative to cephaloridine | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID561444 | Antibacterial activity against Escherichia coli DH10B harboring plasmid BCSK carrying beta-lactamase CMY-33 gene by Etest method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Reduced susceptibility to cefepime among Escherichia coli clinical isolates producing novel variants of CMY-2 beta-lactamase. |
| AID1139537 | Antibacterial activity against Escherichia coli DH5alpha harboring pUCP26 empty vector by CLSI broth microdilution method | 2014 | Journal of medicinal chemistry, May-08, Volume: 57, Issue:9 | Siderophore receptor-mediated uptake of lactivicin analogues in gram-negative bacteria. |
| AID535064 | Antimicrobial activity against Acinetobacter genomic species 13TU ATCC 17903 harboring pOXA-58-7 plasmid by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | Contribution of a plasmid-borne blaOXA-58 gene with its hybrid promoter provided by IS1006 and an ISAba3-like element to beta-lactam resistance in acinetobacter genomic species 13TU. |
| AID544951 | Antimicrobial activity against Klebsiella pneumoniae expressing beta-lactamase CTX by Etest based on multiple determinants | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Characterization and sequence analysis of extended-spectrum-{beta}-lactamase-encoding genes from Escherichia coli, Klebsiella pneumoniae, and Proteus mirabilis isolates collected during tigecycline phase 3 clinical trials. |
| AID511579 | Antimicrobial activity against beta-lactam resistant Pseudomonas aeruginosa PAO1 deficient in ampD and ampDh3 gene selected in vitro after antipseudomonal treatment of intensive care unit patient by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Activity of a new cephalosporin, CXA-101 (FR264205), against beta-lactam-resistant Pseudomonas aeruginosa mutants selected in vitro and after antipseudomonal treatment of intensive care unit patients. |
| AID541811 | Antimicrobial activity against Enterococcus gallinarum clinical isolate after 18 to 22 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Establishment of in vitro susceptibility testing methodologies and comparative activities of piperacillin in combination with the penem {beta}-lactamase inhibitor BLI-489. |
| AID495517 | Antibacterial activity against multidrug-resistant Acinetobacter baumannii BM4675 by antimicrobial susceptibility assay | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Screening and quantification of the expression of antibiotic resistance genes in Acinetobacter baumannii with a microarray. |
| AID1225771 | Antibacterial activity against Escherichia coli EC1011 expressing TEM-26 by broth microdilution method | 2015 | Journal of medicinal chemistry, May-14, Volume: 58, Issue:9 | Discovery of a Cyclic Boronic Acid β-Lactamase Inhibitor (RPX7009) with Utility vs Class A Serine Carbapenemases. |
| AID567584 | Antimicrobial activity against Acinetobacter baumannii by broth dilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | In vitro antimicrobial activity and mutant prevention concentration of colistin against Acinetobacter baumannii. |
| AID531599 | Antimicrobial activity against Klebsiella pneumoniae Kp2792 expressing beta-lactamase SHV-56 by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Molecular and biochemical characterization of SHV-56, a novel inhibitor-resistant beta-lactamase from Klebsiella pneumoniae. |
| AID341108 | Antibacterial activity against Escherichia coli 26R793 by Etest | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8 | First occurrence of an Escherichia coli clinical isolate producing the VIM-1/VIM-2 hybrid metallo-beta-lactamase VIM-12. |
| AID519177 | Antimicrobial activity against MexXY-OprM-overproducing Pseudomonas aeruginosa PAO1 harboring MexY agrW mutant and MexZ mutant gene selected after 8 ug/ml of amikacin exposure | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Relationship between antibiotic use and incidence of MexXY-OprM overproducers among clinical isolates of Pseudomonas aeruginosa. |
| AID547540 | Antimicrobial activity against invasive Streptococcus constellatus obtained from non-cystic fibrosis patient assessed as non-susceptible isolates grown on mueller-Hinton blood agar at 30 ug/ml after 24 hrs at 37 degC by disk diffusion method in presence o | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Macrolide and clindamycin resistance in Streptococcus milleri group isolates from the airways of cystic fibrosis patients. |
| AID368518 | Ratio of Kcat to Km of Pseudomonas aeruginosa VIM2 assessed as drug hydrolysis by spectrophotometry relative to cephaloridine | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID531582 | Antibacterial activity against Enterobacter amnigenus obtained from complicated skin and skin structure infections by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro activity of ceftobiprole against pathogens from two phase 3 clinical trials of complicated skin and skin structure infections. |
| AID368492 | Activity of Escherichia coli CTX-M-15 assessed as drug hydrolysis by spectrophotometry | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID520327 | Antimicrobial activity against Acinetobacter baumannii isolates by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Outbreak of Acinetobacter baumannii with chromosomally encoded VIM-1 undetectable by imipenem-EDTA synergy tests. |
| AID529458 | Antimicrobial activity against Escherichia coli J53 harboring beta-lactamase TEM-1, CTX-M-15 and Oxa-1 by Etest | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Spread of OXA-48-positive carbapenem-resistant Klebsiella pneumoniae isolates in Istanbul, Turkey. |
| AID541540 | Antimicrobial activity against vancomycin-resistant Enterococcus faecium clinical isolate after 18 to 22 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Establishment of in vitro susceptibility testing methodologies and comparative activities of piperacillin in combination with the penem {beta}-lactamase inhibitor BLI-489. |
| AID295845 | Antimicrobial activity against Proteus vulgaris KUKEM1329 by disk diffusion method at 300 ug/disc | 2007 | European journal of medicinal chemistry, Jul, Volume: 42, Issue:7 | Synthesis of some novel heterocyclic compounds derived from diflunisal hydrazide as potential anti-infective and anti-inflammatory agents. |
| AID285364 | Susceptibility of qnr positive Enterobacter cloacae assessed as percentage nonsusceptible isolates | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Prevalence of plasmid-mediated quinolone resistance determinants QnrA, QnrB, and QnrS among clinical isolates of Enterobacter cloacae in a Taiwanese hospital. |
| AID394697 | Antibacterial activity against beta-lactams resistant Pseudomonas aeruginosa isolate expressing AmpC, MexAB-OprM pump, MexXY-OprM pump by macrodilution technique | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10 | Pseudomonas aeruginosa may accumulate drug resistance mechanisms without losing its ability to cause bloodstream infections. |
| AID582925 | Ratio of Kcat to Km for Escherichia coli BL21(DE3) VIM-2 W87F mutant beta-lactamase by spectrophotometer | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | Mutational analysis of VIM-2 reveals an essential determinant for metallo-beta-lactamase stability and folding. |
| AID534880 | Antimicrobial activity against Enterobacter cloacae with derepressed AmpC beta-lactamsae by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activity of doripenem, a carbapenem for the treatment of challenging infections caused by gram-negative bacteria, against recent clinical isolates from the United States. |
| AID562341 | Ratio of Kcat to Km for Chryseobacterium meningosepticum CCUG 4310 beta-lactamase BlaB1 expressed in Escherichia coli DH5alpha by Michaelis-Menten equation | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | IND-6, a highly divergent IND-type metallo-beta-lactamase from Chryseobacterium indologenes strain 597 isolated in Burkina Faso. |
| AID1373284 | Antimicrobial activity against Escherichia coli expressing beta-lactamase IMI-1 by CLSI broth microdilution method | 2018 | Bioorganic & medicinal chemistry letters, 02-15, Volume: 28, Issue:4 | Optimization of novel monobactams with activity against carbapenem-resistant Enterobacteriaceae - Identification of LYS228. |
| AID535129 | Antimicrobial activity against imipenem susceptible Pseudomonas aeruginosa by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activity of doripenem, a carbapenem for the treatment of challenging infections caused by gram-negative bacteria, against recent clinical isolates from the United States. |
| AID535647 | Antimicrobial activity against Group B Streptococcus serotype V 2603 V/R harboring E63K mutation in PBP 2A and L41S mutation in PBP 1B by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | Genetic heterogeneity in pbp genes among clinically isolated group B Streptococci with reduced penicillin susceptibility. |
| AID573360 | Antibacterial activity against ceftazidime-susceptible Klebsiella pneumoniae assessed as resistant isolates by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID564461 | Antimicrobial activity against Pseudomonas aeruginosa isolate 856 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | In vivo efficacy of 1- and 2-gram human simulated prolonged infusions of doripenem against Pseudomonas aeruginosa. |
| AID1373309 | Antimicrobial activity against Escherichia coli expressing beta-lactamase VIM-1 by CLSI broth microdilution method | 2018 | Bioorganic & medicinal chemistry letters, 02-15, Volume: 28, Issue:4 | Optimization of novel monobactams with activity against carbapenem-resistant Enterobacteriaceae - Identification of LYS228. |
| AID285661 | Antimicrobial activity against Pseudomonas aeruginosa 19F2 tracheal isolates from mechanically ventilated chronic respiratory insufficiency patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID285613 | Antimicrobial activity against Pseudomonas aeruginosa 2A5 tracheal isolates from mechanically ventilated chronic respiratory insufficiency patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID573362 | Antibacterial activity against ceftazidime-nonsusceptible Klebsiella pneumoniae assessed as susceptible isolates by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID534887 | Antimicrobial activity against Enterobacter cloacae with derepressed AmpC beta-lactamsae assessed as susceptible isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activity of doripenem, a carbapenem for the treatment of challenging infections caused by gram-negative bacteria, against recent clinical isolates from the United States. |
| AID546428 | Activity at Pseudomonas aeruginosa PDC-3 by spectrophotometer | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Extended-spectrum cephalosporinases in Pseudomonas aeruginosa. |
| AID534651 | Antimicrobial activity against ESBL producing Klebsiella pneumoniae assessed as intermediate isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activity of doripenem, a carbapenem for the treatment of challenging infections caused by gram-negative bacteria, against recent clinical isolates from the United States. |
| AID531587 | Antibacterial activity against Proteus mirabilis obtained from complicated skin and skin structure infections by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro activity of ceftobiprole against pathogens from two phase 3 clinical trials of complicated skin and skin structure infections. |
| AID563966 | Antibacterial activity against Klebsiella pneumoniae 05-560 by Etest method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Characterization of a new metallo-beta-lactamase gene, bla(NDM-1), and a novel erythromycin esterase gene carried on a unique genetic structure in Klebsiella pneumoniae sequence type 14 from India. |
| AID322320 | Antibacterial activity against Escherichia coli INSRA5776 isolates expressing CTX-M-14 and TEM-1B enzymes by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Spread of extended-spectrum beta-lactamase CTX-M-producing escherichia coli clinical isolates in community and nosocomial environments in Portugal. |
| AID1318921 | Antibacterial activity against multidrug/extremely drug-resistant/colistin-susceptible Pseudomonas aeruginosa isolate 260-97103 | 2016 | Journal of medicinal chemistry, 09-22, Volume: 59, Issue:18 | Hybrid Antibiotic Overcomes Resistance in P. aeruginosa by Enhancing Outer Membrane Penetration and Reducing Efflux. |
| AID555212 | Antibacterial activity against Acinetobacter genomosp. 3 isolate 128 by Etest method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Genetic variability among ampC genes from acinetobacter genomic species 3. |
| AID556649 | Antimicrobial activity against multidrug resistant Enterobacter aerogenes isolate 4 by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Occurrence of efflux mechanism and cephalosporinase variant in a population of Enterobacter aerogenes and Klebsiella pneumoniae isolates producing extended-spectrum beta-lactamases. |
| AID565543 | Antibacterial activity against mexB, mexY and mexD expressing Pseudomonas aeruginosa isolate Paebeta-07 harboring A residue at 105 position in PDC- 2 and insertion of ISPa27 sequence in OprD gene by Etest method in presence of cloxacillin | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Molecular epidemiology and mechanisms of carbapenem resistance in Pseudomonas aeruginosa. |
| AID535888 | Antimicrobial activity against aac(6')-Ib-cr-positive Klebsiella pneumoniae JN41T harboring qnrB gene by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | High prevalence of plasmid-mediated quinolone resistance genes qnr and aac(6')-Ib-cr in clinical isolates of Enterobacteriaceae from nine teaching hospitals in China. |
| AID285593 | Antimicrobial activity against Pseudomonas aeruginosa 65.38-4 tracheal isolates from mechanically ventilated tuberculosis patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID522567 | Antimicrobial activity against Escherichia coli isolate 7001178 with AmpC beta-lactamase S287N mutation | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Occurrence of ST23 complex phylogroup A Escherichia coli isolates producing extended-spectrum AmpC beta-lactamase in a French hospital. |
| AID544891 | Antimicrobial activity against class A extended spectrum beta-lactamase- producing Klebsiella pneumoniae clinical isolate after 18 to 22 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Establishment of in vitro susceptibility testing methodologies and comparative activities of piperacillin in combination with the penem {beta}-lactamase inhibitor BLI-489. |
| AID285260 | Antimicrobial activity against recombinant Escherichia coli DH5-alpha isolate expressing pBK-TEM-28 and ESBL by disk diffusion assay | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Evolution of TEM-type enzymes: biochemical and genetic characterization of two new complex mutant TEM enzymes, TEM-151 and TEM-152, from a single patient. |
| AID517949 | Antimicrobial activity against Providencia stuartii by broth dilution method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli. |
| AID499058 | Antimicrobial activity against carbapenem-resistant Enterobacter cloacae GX24 deficient in TEM-1, DHA-1, aac(6')-Ib, ompC by CLSI method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Phenotypic and genotypic characterization of Enterobacteriaceae with decreased susceptibility to carbapenems: results from large hospital-based surveillance studies in China. |
| AID528839 | Antimicrobial activity against vancomycin-resistant Enterococcus sp. isolated from ICU patient blood assessed as resistant isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Antimicrobial-resistant pathogens in intensive care units in Canada: results of the Canadian National Intensive Care Unit (CAN-ICU) study, 2005-2006. |
| AID1079936 | Choleostatic liver toxicity, either proven histopathologically or where the ratio of maximal ALT or AST activity above normal to that of Alkaline Phosphatase is < 2 (see ACUTE). Value is number of references indexed. [column 'CHOLE' in source] | |||
| AID511390 | Antibacterial activity against Proteus mirabilis by broth dilution method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Comparative in vitro activities of nemonoxacin (TG-873870), a novel nonfluorinated quinolone, and other quinolones against clinical isolates. |
| AID555217 | Antibacterial activity against Escherichia coli DH5alpha carrying ampC gene of Acinetobacter genomosp. 3 isolate 56 by Etest method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Genetic variability among ampC genes from acinetobacter genomic species 3. |
| AID285649 | Antimicrobial activity against Pseudomonas aeruginosa 19B6 tracheal isolates from mechanically ventilated chronic respiratory insufficiency patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID554401 | Antimicrobial activity against Pseudomonas aeruginosa isolate 2998 obtained from cystic fibrosis patient by disk diffusion method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Efflux unbalance in Pseudomonas aeruginosa isolates from cystic fibrosis patients. |
| AID323041 | Antimicrobial activity against extended-spectrum-beta-lactamase producing Proteus mirabilis isolates | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Predictors of mortality in patients with bloodstream infections caused by extended-spectrum-beta-lactamase-producing Enterobacteriaceae: importance of inadequate initial antimicrobial treatment. |
| AID495804 | Antimicrobial activity against Klebsiella pneumoniae 2878 strain expressing beta-lactamase VIM-19 by microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Novel VIM metallo-beta-lactamase variant from clinical isolates of Enterobacteriaceae from Algeria. |
| AID530349 | Antimicrobial activity against Escherichia coli TOP10 harboring pQep plasmid carrying qepA2 gene by disk diffusion method | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Plasmid-mediated quinolone resistance pump QepA2 in an Escherichia coli isolate from France. |
| AID498833 | Antimicrobial activity against Klebsiella pneumoniae CY1T expressing SHV-11, DHA-1 by CLSI method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Phenotypic and genotypic characterization of Enterobacteriaceae with decreased susceptibility to carbapenems: results from large hospital-based surveillance studies in China. |
| AID1139539 | Antibacterial activity against Escherichia coli DH5alpha expressing beta-lactamase SHV-12 by CLSI broth microdilution method | 2014 | Journal of medicinal chemistry, May-08, Volume: 57, Issue:9 | Siderophore receptor-mediated uptake of lactivicin analogues in gram-negative bacteria. |
| AID498813 | Antimicrobial activity against Escherichia coli ZJ87T expressing KPC-2 by CLSI method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Phenotypic and genotypic characterization of Enterobacteriaceae with decreased susceptibility to carbapenems: results from large hospital-based surveillance studies in China. |
| AID394683 | Antibacterial activity against Pseudomonas aeruginosa clinical isolate by macrodilution technique | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10 | Pseudomonas aeruginosa may accumulate drug resistance mechanisms without losing its ability to cause bloodstream infections. |
| AID326266 | Antibacterial activity against Escherichia coli K12 carrying pR3521 encoding SCO1 by agar dilution technique | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | SCO-1, a novel plasmid-mediated class A beta-lactamase with carbenicillinase characteristics from Escherichia coli. |
| AID528835 | Antimicrobial activity against vancomycin-resistant Enterococcus sp. isolated from ICU patient respiratory tract assessed as resistant isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Antimicrobial-resistant pathogens in intensive care units in Canada: results of the Canadian National Intensive Care Unit (CAN-ICU) study, 2005-2006. |
| AID573206 | Antimicrobial activity against mutS::lox-deficient Pseudomonas aeruginosa PAOMSB biofilm harboring nfxB T562C mutant gene selected at 4 ug/ml of azithromycin after 4 passages by Etest method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Azithromycin in Pseudomonas aeruginosa biofilms: bactericidal activity and selection of nfxB mutants. |
| AID584564 | Antimicrobial activity against Acinetobacter lwoffii isolate K expressing beta-lactamase OXA-58 isolated from blood culture of patient by vitek 2 system | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | In vivo selection of a missense mutation in adeR and conversion of the novel blaOXA-164 gene into blaOXA-58 in carbapenem-resistant Acinetobacter baumannii isolates from a hospitalized patient. |
| AID556676 | Antimicrobial activity against multidrug resistant Klebsiella pneumoniae isolate 3 by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Occurrence of efflux mechanism and cephalosporinase variant in a population of Enterobacter aerogenes and Klebsiella pneumoniae isolates producing extended-spectrum beta-lactamases. |
| AID531606 | Ratio of Kcat to Km for Escherichia coli Inhibitor-resistant beta-lactamase SHV-56 | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Molecular and biochemical characterization of SHV-56, a novel inhibitor-resistant beta-lactamase from Klebsiella pneumoniae. |
| AID544685 | Antimicrobial activity against Klebsiella pneumoniae clinical isolate after 18 to 22 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Establishment of in vitro susceptibility testing methodologies and comparative activities of piperacillin in combination with the penem {beta}-lactamase inhibitor BLI-489. |
| AID528818 | Antimicrobial activity against carbapenem-resistant Enterobacter cloacae isolated from ICU patient blood assessed as resistant isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Antimicrobial-resistant pathogens in intensive care units in Canada: results of the Canadian National Intensive Care Unit (CAN-ICU) study, 2005-2006. |
| AID571698 | Antimicrobial activity against ISAba1 linked with the blaOXA-51-type beta-lactamase harboring Acinetobacter baumannii alpha clonal group isolate 6 expressing ampC, ompA, adeB, adeM, aacC1, aadA1 by Etest method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Correlation of antimicrobial resistance with beta-lactamases, the OmpA-like porin, and efflux pumps in clinical isolates of Acinetobacter baumannii endemic to New York City. |
| AID1318924 | Antibacterial activity against pandrug-resistant Pseudomonas aeruginosa isolate 91433 | 2016 | Journal of medicinal chemistry, 09-22, Volume: 59, Issue:18 | Hybrid Antibiotic Overcomes Resistance in P. aeruginosa by Enhancing Outer Membrane Penetration and Reducing Efflux. |
| AID542056 | Antibacterial activity against Klebsiella pneumoniae expressing CTX-M group 1 beta-lactamase by Etest method in presence of clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Nationwide survey of CTX-M-type extended-spectrum beta-lactamases among Klebsiella pneumoniae isolates in Slovenian hospitals. |
| AID583019 | Antimicrobial activity against OmpC/OmpF porin deficient Escherichia coli HB4 transformed with Escherichia coli DH10B plasmid carrying DHA-1 by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Phenotypic and biochemical comparison of the carbapenem-hydrolyzing activities of five plasmid-borne AmpC β-lactamases. |
| AID533878 | Antibacterial activity against amoxicillin-resistant Streptococcus pneumoniae isolate by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | In vitro activity of ceftaroline against Streptococcus pneumoniae isolates exhibiting resistance to penicillin, amoxicillin, and cefotaxime. |
| AID561628 | Antimicrobial activity against ampD1-deficient Stenotrophomonas maltophilia KJ by twofold serial agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | AmpDI is involved in expression of the chromosomal L1 and L2 beta-lactamases of Stenotrophomonas maltophilia. |
| AID285258 | Antimicrobial activity against recombinant Escherichia coli DH5-alpha CL1179 isolate expressing pBK-TEM-152 and CMT by disk diffusion assay | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Evolution of TEM-type enzymes: biochemical and genetic characterization of two new complex mutant TEM enzymes, TEM-151 and TEM-152, from a single patient. |
| AID520801 | Antimicrobial activity against CTX-M-2 producing Klebsiella pneumoniae with PFGE pulsotype I by Etest | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Multiclonal outbreak of Klebsiella pneumoniae producing extended-spectrum beta-lactamase CTX-M-2 and novel variant CTX-M-59 in a neonatal intensive care unit in Brazil. |
| AID558040 | Antimicrobial activity against blaKPC-positive Klebsiella pneumoniae S3 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Genetic organization of transposase regions surrounding blaKPC carbapenemase genes on plasmids from Klebsiella strains isolated in a New York City hospital. |
| AID531746 | Antibacterial activity against Pseudomonas aeruginosa FE60 by twofold serial dilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Resistance and virulence of Pseudomonas aeruginosa clinical strains overproducing the MexCD-OprJ efflux pump. |
| AID544678 | Antimicrobial activity against AmpC beta-lactamase-producing Escherichia coli clinical isolate after 18 to 22 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Establishment of in vitro susceptibility testing methodologies and comparative activities of piperacillin in combination with the penem {beta}-lactamase inhibitor BLI-489. |
| AID301081 | Antibacterial activity against Toho 2 (ESBL) producing Escherichia coli SR-21003 after 20 hrs by agar dilution method | 2007 | Bioorganic & medicinal chemistry, Nov-01, Volume: 15, Issue:21 | A novel series of parenteral cephalosporins exhibiting potent activities against Pseudomonas aeruginosa and other Gram-negative pathogens: synthesis and structure-activity relationships. |
| AID498837 | Antimicrobial activity against carbapenem-resistant Klebsiella pneumoniae PU8 deficient in SHV-11, DHA-1, aac(6')-Ib-cr, ompK35/36 by CLSI method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Phenotypic and genotypic characterization of Enterobacteriaceae with decreased susceptibility to carbapenems: results from large hospital-based surveillance studies in China. |
| AID583026 | Antimicrobial activity against Escherichia coli TOP10 transformed with Escherichia coli EC-6 plasmid carrying AmpC-B2 by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Phenotypic and biochemical comparison of the carbapenem-hydrolyzing activities of five plasmid-borne AmpC β-lactamases. |
| AID532196 | Antimicrobial activity against aac(6')-Ib-cr-negative Enterobacter cloacae WH42 harboring wild-type GyrA, ParC, GyrB and qnrA genes by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | High prevalence of plasmid-mediated quinolone resistance genes qnr and aac(6')-Ib-cr in clinical isolates of Enterobacteriaceae from nine teaching hospitals in China. |
| AID535858 | Antimicrobial activity against aac(6')-Ib-cr-positive Klebsiella pneumoniae GZ40T harboring qnrB gene by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | High prevalence of plasmid-mediated quinolone resistance genes qnr and aac(6')-Ib-cr in clinical isolates of Enterobacteriaceae from nine teaching hospitals in China. |
| AID582970 | Antimicrobial activity against nagZ::lox gene-deficient Pseudomonas aeruginosa PAO1 by Etest method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | NagZ inactivation prevents and reverts beta-lactam resistance, driven by AmpD and PBP 4 mutations, in Pseudomonas aeruginosa. |
| AID584848 | Ratio of Kcat to Km for Aeromonas allosaccharophila AL-1 beta-lactamase PER2 | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | PER-6, an extended-spectrum beta-lactamase from Aeromonas allosaccharophila. |
| AID285617 | Antimicrobial activity against Pseudomonas aeruginosa 5F2 tracheal isolates from mechanically ventilated chronic respiratory insufficiency patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID571914 | Antimicrobial activity against ISAba1 linked with the blaOXA-51-type beta-lactamase harboring Acinetobacter baumannii zeta clonal group isolate 21 expressing ampC, ompA, adeB, adeM, aacC2, blaSHV-5 by Etest method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Correlation of antimicrobial resistance with beta-lactamases, the OmpA-like porin, and efflux pumps in clinical isolates of Acinetobacter baumannii endemic to New York City. |
| AID558045 | Antimicrobial activity against blaKPC-positive Klebsiella pneumoniae S8 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Genetic organization of transposase regions surrounding blaKPC carbapenemase genes on plasmids from Klebsiella strains isolated in a New York City hospital. |
| AID561658 | Antimicrobial activity against Pseudomonas aeruginosa isolate OC14812 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Effect of MexXY overexpression on ceftobiprole susceptibility in Pseudomonas aeruginosa. |
| AID541022 | Activity at Burkholderia cenocepacia 07-34 beta-lactamase PenB1 expressed in Escherichia coli Top10 by UV-spectrophotometry | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Naturally occurring Class A ss-lactamases from the Burkholderia cepacia complex. |
| AID565546 | Antibacterial activity against oprD, mexB, mexY and mexD expressing Pseudomonas aeruginosa isolate Paebeta-10 harboring A residue at 105 position in PDC- 2 by Etest method in presence of cloxacillin | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Molecular epidemiology and mechanisms of carbapenem resistance in Pseudomonas aeruginosa. |
| AID285366 | Susceptibility of metallo beta lactamase and extended spectrum beta lactamase deficient qnr positive Enterobacter cloacae assessed as percentage nonsusceptible isolates | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Prevalence of plasmid-mediated quinolone resistance determinants QnrA, QnrB, and QnrS among clinical isolates of Enterobacter cloacae in a Taiwanese hospital. |
| AID530339 | Activity of Pseudomonas aeruginosa VIM-13 beta-lactamase | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Characterization of the new metallo-beta-lactamase VIM-13 and its integron-borne gene from a Pseudomonas aeruginosa clinical isolate in Spain. |
| AID531787 | Antibacterial activity against Enterobacter aerogenes obtained from complicated skin and skin structure infections by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro activity of ceftobiprole against pathogens from two phase 3 clinical trials of complicated skin and skin structure infections. |
| AID531607 | Ratio of Kcat to Km for Escherichia coli beta-lactamase SHV-11 | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Molecular and biochemical characterization of SHV-56, a novel inhibitor-resistant beta-lactamase from Klebsiella pneumoniae. |
| AID532397 | Antibacterial activity against VIM-1 producing Pseudomonas aeruginosa clone D isolate VA-06X-69 by Etest method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | First countrywide survey of acquired metallo-beta-lactamases in gram-negative pathogens in Italy. |
| AID534612 | Antimicrobial activity against Ceftazidime non-susceptible Enterobacteriaceae assessed as resistant isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activity of doripenem, a carbapenem for the treatment of challenging infections caused by gram-negative bacteria, against recent clinical isolates from the United States. |
| AID1361169 | Antimicrobial activity against IMP-1 producing Pseudomonas aeruginosa SR27060 in presence of human apo-transferrin by broth microdilution method | 2018 | European journal of medicinal chemistry, Jul-15, Volume: 155 | Cefiderocol (S-649266), A new siderophore cephalosporin exhibiting potent activities against Pseudomonas aeruginosa and other gram-negative pathogens including multi-drug resistant bacteria: Structure activity relationship. |
| AID559271 | Antimicrobial activity against Proteus vulgaris Pv8 expressing beta-lactamase PER-1 by Etest | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Emergence of extended-spectrum beta-lactamase PER-1 in Proteus vulgaris and Providencia stuartii isolates from Algiers, Algeria. |
| AID519180 | Antimicrobial activity against MexXY-OprM-overproducing Pseudomonas aeruginosa PAO1 harboring MexY agrW mutant and MexZ mutant gene selected after 1 ug/ml of oflaxacin exposure | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Relationship between antibiotic use and incidence of MexXY-OprM overproducers among clinical isolates of Pseudomonas aeruginosa. |
| AID528740 | Antimicrobial activity against penicillin-resistant Streptococcus agalactiae ATCC BAA-611 harboring PBP-2X Q557E mutant gene by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | First molecular characterization of group B streptococci with reduced penicillin susceptibility. |
| AID368309 | Activity of Escherichia coli TEM1 assessed as drug hydrolysis by spectrophotometry | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID405084 | Activity of Citrobacter freundii PER2 beta lactamase | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | Biochemical characterization of PER-2 and genetic environment of blaPER-2. |
| AID340727 | Antimicrobial activity against Enterobacter isolates producing extended-spectrum beta-lactamase CTX-M-2 by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8 | Extended-spectrum beta-lactamases of the CTX-M type now in Switzerland. |
| AID520793 | Antimicrobial activity against CTX-M-2 producing Klebsiella pneumoniae with PFGE pulsotype A by Etest | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Multiclonal outbreak of Klebsiella pneumoniae producing extended-spectrum beta-lactamase CTX-M-2 and novel variant CTX-M-59 in a neonatal intensive care unit in Brazil. |
| AID555686 | Antimicrobial activity against Escherichia coli ATCC 25922 by disk diffusion method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Novel plasmid-encoded ceftazidime-hydrolyzing CTX-M-53 extended-spectrum beta-lactamase from Salmonella enterica serotypes Westhampton and Senftenberg. |
| AID559901 | Antimicrobial activity against Klebsiella pneumoniae 278sp by Etest method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | First detection of plasmid-encoded blaOXY beta-lactamase. |
| AID499144 | Half life in immunocompromized SKH1 mouse plasma at 50 mg/kg, sc | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vivo activity of ceftobiprole in murine skin infections due to Staphylococcus aureus and Pseudomonas aeruginosa. |
| AID534867 | Antimicrobial activity against ESBL producing Proteus mirabilis assessed as susceptible isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activity of doripenem, a carbapenem for the treatment of challenging infections caused by gram-negative bacteria, against recent clinical isolates from the United States. |
| AID530340 | Activity of Pseudomonas aeruginosa VIM-1 beta-lactamase | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Characterization of the new metallo-beta-lactamase VIM-13 and its integron-borne gene from a Pseudomonas aeruginosa clinical isolate in Spain. |
| AID535660 | Antimicrobial activity against aac(6')-Ib-cr-positive Enterobacter cloacae FJ63 harboring GyrA S83I, GyrA D87A, ParC S80I mutant, wild-type GyrB and qnrS genes by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | High prevalence of plasmid-mediated quinolone resistance genes qnr and aac(6')-Ib-cr in clinical isolates of Enterobacteriaceae from nine teaching hospitals in China. |
| AID285575 | Antimicrobial activity against Pseudomonas aeruginosa 65.18-2 tracheal isolates from mechanically ventilated tuberculosis patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID564453 | Antimicrobial activity against Pseudomonas aeruginosa isolate 1050 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | In vivo efficacy of 1- and 2-gram human simulated prolonged infusions of doripenem against Pseudomonas aeruginosa. |
| AID571034 | Antimicrobial activity against Pseudomonas aeruginosa isolate PA22 obtained from patient with cystic fibrosis by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Role of ampD homologs in overproduction of AmpC in clinical isolates of Pseudomonas aeruginosa. |
| AID565718 | Antibacterial activity against oprD, mexB, mexY and mexD expressing Pseudomonas aeruginosa isolate Paebeta-23 harboring A residue at 105 position in PDC- 5 by Etest method in presence of cloxacillin | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Molecular epidemiology and mechanisms of carbapenem resistance in Pseudomonas aeruginosa. |
| AID495913 | Ratio of Kcat to Km for beta-lactamase VIM-19 expressed in Escherichia coli TOP10 by spectrophotometry | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | VIM-19, a metallo-beta-lactamase with increased carbapenemase activity from Escherichia coli and Klebsiella pneumoniae. |
| AID565511 | Antibacterial activity against oprD, mexB, mexY and mexD expressing Pseudomonas aeruginosa isolate Paebeta-29 harboring A residue at 105 position in PDC- 8 by Etest method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Molecular epidemiology and mechanisms of carbapenem resistance in Pseudomonas aeruginosa. |
| AID534631 | Antimicrobial activity against ESBL producing Escherichia coli assessed as intermediate isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activity of doripenem, a carbapenem for the treatment of challenging infections caused by gram-negative bacteria, against recent clinical isolates from the United States. |
| AID544679 | Antimicrobial activity against AmpC beta-lactamase-producing Citrobacter freundii clinical isolate after 18 to 22 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Establishment of in vitro susceptibility testing methodologies and comparative activities of piperacillin in combination with the penem {beta}-lactamase inhibitor BLI-489. |
| AID573202 | Antimicrobial activity against mutS::lox-deficient Pseudomonas aeruginosa PAOMSB biofilm harboring deletion od C534 in nfxB mutant gene selected at 4 ug/ml of azithromycin after 2 passages by Etest method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Azithromycin in Pseudomonas aeruginosa biofilms: bactericidal activity and selection of nfxB mutants. |
| AID324358 | Antibacterial activity against Escherichia coli DH10B expressing SCO1 by agar dilution technique | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Identification of the novel narrow-spectrum beta-lactamase SCO-1 in Acinetobacter spp. from Argentina. |
| AID517953 | Antimicrobial activity against Escherichia coli by broth dilution method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli. |
| AID573347 | Antibacterial activity against ceftazidime-susceptible Enterobacter cloacae assessed as susceptible isolates by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID528983 | Antimicrobial activity against Haemophilus influenzae isolated from ICU patient wound assessed as resistant isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Antimicrobial-resistant pathogens in intensive care units in Canada: results of the Canadian National Intensive Care Unit (CAN-ICU) study, 2005-2006. |
| AID499063 | Antimicrobial activity against Escherichia coli HX74T expressing CTX-M-3 by CLSI method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Phenotypic and genotypic characterization of Enterobacteriaceae with decreased susceptibility to carbapenems: results from large hospital-based surveillance studies in China. |
| AID521998 | Antimicrobial activity against Klebsiella pneumoniae isolate Kp5A expressing beta-lactamase OXA-48 and SHV-5 by Etest method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Spread of OXA-48-encoding plasmid in Turkey and beyond. |
| AID531315 | Activity of Pseudomonas aeruginosa beta-lactamase VIM-2 by spectrophotometry | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Kinetic characterization of VIM-7, a divergent member of the VIM metallo-beta-lactamase family. |
| AID557207 | Creatinine clearance in critically ill patient with ventilator-associated pneumoniae and normal renal function at 2 g/kg administered as 0.5 hr infusion every 12 hrs | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Population pharmacokinetics of high-dose, prolonged-infusion cefepime in adult critically ill patients with ventilator-associated pneumonia. |
| AID573366 | Antibacterial activity against ceftazidime-susceptible Morganella morganii assessed as resistant isolates by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID546171 | Antimicrobial activity against AmpC overproducing Pseudomonas aeruginosa isolate Pae-beta-11 with PDC-2 variant by Etest | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Extended-spectrum cephalosporinases in Pseudomonas aeruginosa. |
| AID558799 | Antimicrobial activity against extended spectrum beta-lactamase-expressing Klebsiella oxytoca assessed as percent susceptible isolates by CLSI method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Emergence of high levels of extended-spectrum-beta-lactamase-producing gram-negative bacilli in the Asia-Pacific region: data from the Study for Monitoring Antimicrobial Resistance Trends (SMART) program, 2007. |
| AID541546 | Antimicrobial activity against penicillin-susceptible Streptococcus pneumoniae clinical isolate after 18 to 22 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Establishment of in vitro susceptibility testing methodologies and comparative activities of piperacillin in combination with the penem {beta}-lactamase inhibitor BLI-489. |
| AID368511 | Ratio of Kcat to Km of Serratia marcescens SME3 assessed as drug hydrolysis by spectrophotometry | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID520794 | Antimicrobial activity against CTX-M-2 producing Klebsiella pneumoniae with PFGE pulsotype B by Etest | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Multiclonal outbreak of Klebsiella pneumoniae producing extended-spectrum beta-lactamase CTX-M-2 and novel variant CTX-M-59 in a neonatal intensive care unit in Brazil. |
| AID587730 | Activity of Pseudomonas aeruginosa strain PS 297 metallo-beta-lactamase IMP-18 expressed in Escherichia coli BL21(DE3) assessed as substrate hydrolysis using 100 uM nitrocefin | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1 | Genetic context and biochemical characterization of the IMP-18 metallo-beta-lactamase identified in a Pseudomonas aeruginosa isolate from the United States. |
| AID368539 | Activity of Pseudomonas aeruginosa 4352 AmpC assessed as drug hydrolysis by spectrophotometry | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID563156 | Antibacterial activity against Pseudomonas aeruginosa isolate 19BR by Etest | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | Involvement of pmrAB and phoPQ in polymyxin B adaptation and inducible resistance in non-cystic fibrosis clinical isolates of Pseudomonas aeruginosa. |
| AID545446 | Antimicrobial activity against extended-spectrum beta-lactamase-negative Klebsiella pneumoniae assessed as percent susceptible isolates by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Susceptibility of gram-negative pathogens isolated from patients with complicated intra-abdominal infections in the United States, 2007-2008: results of the Study for Monitoring Antimicrobial Resistance Trends (SMART). |
| AID573382 | Antibacterial activity against beta lactamase-positive Haemophilus influenzae by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID368505 | Activity of Escherichia coli KPC2 assessed as drug hydrolysis by spectrophotometry | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID541537 | Antimicrobial activity against vancomycin-resistant Enterococcus faecalis clinical isolate after 18 to 22 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Establishment of in vitro susceptibility testing methodologies and comparative activities of piperacillin in combination with the penem {beta}-lactamase inhibitor BLI-489. |
| AID554394 | Antimicrobial activity against Pseudomonas aeruginosa isolate 2715 obtained from cystic fibrosis patient by disk diffusion method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Efflux unbalance in Pseudomonas aeruginosa isolates from cystic fibrosis patients. |
| AID534602 | Antimicrobial activity against ceftazidime-susceptible Enterobacteriaceae by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activity of doripenem, a carbapenem for the treatment of challenging infections caused by gram-negative bacteria, against recent clinical isolates from the United States. |
| AID511582 | Antimicrobial activity against beta-lactam resistant Pseudomonas aeruginosa PAOD1 harboring oprD spontaneous mutant selected in vitro after antipseudomonal treatment of intensive care unit patient by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Activity of a new cephalosporin, CXA-101 (FR264205), against beta-lactam-resistant Pseudomonas aeruginosa mutants selected in vitro and after antipseudomonal treatment of intensive care unit patients. |
| AID528523 | Antimicrobial activity against penicillin-resistant Streptococcus agalactiae ATCC 12403 by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | First molecular characterization of group B streptococci with reduced penicillin susceptibility. |
| AID562768 | Antimicrobial activity against Escherichia coli DH10B transformant harboring blaTEM-168 gene by Etest | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | TEM-168, a heretofore laboratory-derived TEM beta-lactamase variant found in an Escherichia coli clinical isolate. |
| AID543411 | Antimicrobial activity against Shigella sonnei UIH-1 expressing beta-lactamase CTX-M-64 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Novel chimeric beta-lactamase CTX-M-64, a hybrid of CTX-M-15-like and CTX-M-14 beta-lactamases, found in a Shigella sonnei strain resistant to various oxyimino-cephalosporins, including ceftazidime. |
| AID571916 | Antimicrobial activity against ISAba1 linked with the blaOXA-51-type beta-lactamase harboring Acinetobacter baumannii zeta clonal group isolate 22 expressing ampC, ompA, adeB, adeM, aadA1, aacA4, aacC2, blaSHV-5 by Etest method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Correlation of antimicrobial resistance with beta-lactamases, the OmpA-like porin, and efflux pumps in clinical isolates of Acinetobacter baumannii endemic to New York City. |
| AID547523 | Antimicrobial activity against Streptococcus constellatus obtained from patient with cystic fibrosis assessed as non-susceptible isolates grown on brain heart infusion agar at 30 ug/ml after 24 hrs at 37 degC by disk diffusion method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Macrolide and clindamycin resistance in Streptococcus milleri group isolates from the airways of cystic fibrosis patients. |
| AID544496 | Ratio of MIC for Escherichia coli TOP10 harboring beta-lactamase KPC-4 to MIC for Escherichia coli TOP10 | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Phenotypic and enzymatic comparative analysis of the novel KPC variant KPC-5 and its evolutionary variants, KPC-2 and KPC-4. |
| AID1373287 | Antimicrobial activity against Escherichia coli expressing beta-lactamase KPC-4 by CLSI broth microdilution method | 2018 | Bioorganic & medicinal chemistry letters, 02-15, Volume: 28, Issue:4 | Optimization of novel monobactams with activity against carbapenem-resistant Enterobacteriaceae - Identification of LYS228. |
| AID285662 | Antimicrobial activity against Pseudomonas aeruginosa 22D2 tracheal isolates from mechanically ventilated chronic respiratory insufficiency patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID520384 | Antimicrobial activity Escherichia coli DH5alpha expressing beta lactamase VIM-2 by agar macrodilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Biochemical characterization of metallo-beta-lactamase VIM-11 from a Pseudomonas aeruginosa clinical strain. |
| AID535891 | Antimicrobial activity against aac(6')-Ib-cr-negative Citrobacter freundii JN64 harboring GyrA T83I, wild-type ParC, GyrB and qnrA genes by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | High prevalence of plasmid-mediated quinolone resistance genes qnr and aac(6')-Ib-cr in clinical isolates of Enterobacteriaceae from nine teaching hospitals in China. |
| AID534082 | Antibacterial activity against cefotaxime-resistant Streptococcus pneumoniae isolate by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | In vitro activity of ceftaroline against Streptococcus pneumoniae isolates exhibiting resistance to penicillin, amoxicillin, and cefotaxime. |
| AID372603 | Antibacterial activity against Escherichia coli BER1 producing beta-lactamase TEM-158 | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | TEM-158 (CMT-9), a new member of the CMT-type extended-spectrum beta-lactamases. |
| AID530341 | Ratio of Kcat to Km for Pseudomonas aeruginosa VIM-1 beta-lactamase | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Characterization of the new metallo-beta-lactamase VIM-13 and its integron-borne gene from a Pseudomonas aeruginosa clinical isolate in Spain. |
| AID324852 | Antimicrobial activity against Acinetobacter baumannii D54 by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Tigecycline Efflux as a Mechanism for Nonsusceptibility in Acinetobacter baumannii. |
| AID572134 | Antimicrobial activity against Acinetobacter baumannii nu clonal group isolate 34 expressing ampC, ompA, adeB, adeM by Etest method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Correlation of antimicrobial resistance with beta-lactamases, the OmpA-like porin, and efflux pumps in clinical isolates of Acinetobacter baumannii endemic to New York City. |
| AID528838 | Antimicrobial activity against vancomycin-resistant Enterococcus sp. assessed as resistant isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Antimicrobial-resistant pathogens in intensive care units in Canada: results of the Canadian National Intensive Care Unit (CAN-ICU) study, 2005-2006. |
| AID1079943 | Malignant tumor, proven histopathologically. Value is number of references indexed. [column 'T.MAL' in source] | |||
| AID1373295 | Antimicrobial activity against Escherichia coli expressing beta-lactamase VEB-1 by CLSI broth microdilution method | 2018 | Bioorganic & medicinal chemistry letters, 02-15, Volume: 28, Issue:4 | Optimization of novel monobactams with activity against carbapenem-resistant Enterobacteriaceae - Identification of LYS228. |
| AID285664 | Antimicrobial activity against Pseudomonas aeruginosa 22D9 tracheal isolates from mechanically ventilated chronic respiratory insufficiency patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID561385 | Antibacterial activity against Escherichia coli isolate ARL06-39 harboring beta-lactamase CMY 30 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | CMY-29 and CMY-30, two novel plasmid-mediated AmpC beta-lactamases. |
| AID570782 | Antimicrobial activity against multidrug-resistant Acinetobacter baumannii assessed as resistant isolates by disk diffusion method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Genetic basis of multidrug resistance in Acinetobacter baumannii clinical isolates at a tertiary medical center in Pennsylvania. |
| AID540949 | Antimicrobial activity against Escherichia coli DH5[alpha] harboring pBCSK plasmid by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | CMY-31 and CMY-36 cephalosporinases encoded by ColE1-like plasmids. |
| AID567307 | Antimicrobial activity against SHV-12 ESBL producing Pseudomonas aeruginosa isolate 2205 isolated from burn patient by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Acquisition of a transposon encoding extended-spectrum beta-lactamase SHV-12 by Pseudomonas aeruginosa isolates during the clinical course of a burn patient. |
| AID534643 | Antimicrobial activity against ESBL producing Klebsiella pneumoniae by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activity of doripenem, a carbapenem for the treatment of challenging infections caused by gram-negative bacteria, against recent clinical isolates from the United States. |
| AID574436 | Antimicrobial activity against Escherichia coli isolate 547T expressing beta-lactamase KPC2 and PFGE cluster 4 isolated from blood of patient by vitek-2 method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Carbapenem-resistant KPC-2-producing Escherichia coli in a Tel Aviv Medical Center, 2005 to 2008. |
| AID534083 | Antibacterial activity against cefotaxime-resistant Streptococcus pneumoniae assessed as percent susceptible isolates by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | In vitro activity of ceftaroline against Streptococcus pneumoniae isolates exhibiting resistance to penicillin, amoxicillin, and cefotaxime. |
| AID546169 | Antimicrobial activity against AmpC overproducing Pseudomonas aeruginosa isolate Pae-beta-09 with PDC-2 variant by Etest | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Extended-spectrum cephalosporinases in Pseudomonas aeruginosa. |
| AID561677 | Antimicrobial activity against Pseudomonas aeruginosa isolate OC14551 harboring plasmid JAK16 expressing mexXY gene by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Effect of MexXY overexpression on ceftobiprole susceptibility in Pseudomonas aeruginosa. |
| AID1373324 | Antimicrobial activity against Escherichia coli expressing beta-lactamase Oxa-225 by CLSI broth microdilution method | 2018 | Bioorganic & medicinal chemistry letters, 02-15, Volume: 28, Issue:4 | Optimization of novel monobactams with activity against carbapenem-resistant Enterobacteriaceae - Identification of LYS228. |
| AID564021 | Antibacterial activity against Pseudomonas aeruginosa PAO1 harboring cloned pUCPOXA-2 by Etest | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Detection of the novel extended-spectrum beta-lactamase OXA-161 from a plasmid-located integron in Pseudomonas aeruginosa clinical isolates from Spain. |
| AID557200 | Creatinine clearance in critically ill patient with ventilator-associated pneumoniae at 2 g/kg administered as 3 hr infusion every 8 hrs by HPLC | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Population pharmacokinetics of high-dose, prolonged-infusion cefepime in adult critically ill patients with ventilator-associated pneumonia. |
| AID528973 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus assessed as resistant isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Antimicrobial-resistant pathogens in intensive care units in Canada: results of the Canadian National Intensive Care Unit (CAN-ICU) study, 2005-2006. |
| AID508722 | Antibacterial activity against carbapenem-resistant Pseudomonas aeruginosa isolate 1C3 PTOL1 harboring acquired beta-lactamase OXA-17 by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2 | Activity of a new antipseudomonal cephalosporin, CXA-101 (FR264205), against carbapenem-resistant and multidrug-resistant Pseudomonas aeruginosa clinical strains. |
| AID1225772 | Antibacterial activity against Enterobacter cloacae ECL1003 expressing TEM/SHV by broth microdilution method | 2015 | Journal of medicinal chemistry, May-14, Volume: 58, Issue:9 | Discovery of a Cyclic Boronic Acid β-Lactamase Inhibitor (RPX7009) with Utility vs Class A Serine Carbapenemases. |
| AID508723 | Antibacterial activity against carbapenem-resistant Pseudomonas aeruginosa isolate 1E1 PpA1 harboring acquired beta-lactamase OXA-144 by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2 | Activity of a new antipseudomonal cephalosporin, CXA-101 (FR264205), against carbapenem-resistant and multidrug-resistant Pseudomonas aeruginosa clinical strains. |
| AID285586 | Antimicrobial activity against Pseudomonas aeruginosa 65.36-1 tracheal isolates from mechanically ventilated tuberculosis patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID394686 | Antibacterial activity against beta-lactams resistant Pseudomonas aeruginosa isolate expressing MexXY-OprM pump by macrodilution technique | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10 | Pseudomonas aeruginosa may accumulate drug resistance mechanisms without losing its ability to cause bloodstream infections. |
| AID572142 | Antimicrobial activity against Acinetobacter baumannii unique clonal group isolate 38 expressing ampC, ompA, adeB, adeM by Etest method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Correlation of antimicrobial resistance with beta-lactamases, the OmpA-like porin, and efflux pumps in clinical isolates of Acinetobacter baumannii endemic to New York City. |
| AID285647 | Antimicrobial activity against Pseudomonas aeruginosa 19B1 tracheal isolates from mechanically ventilated chronic respiratory insufficiency patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID544671 | Antimicrobial activity against Citrobacter koseri clinical isolate after 18 to 22 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Establishment of in vitro susceptibility testing methodologies and comparative activities of piperacillin in combination with the penem {beta}-lactamase inhibitor BLI-489. |
| AID285512 | Antibacterial activity against Escherichia coli after 24 hrs by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | In vitro and in vivo antibacterial activities of heteroaryl isothiazolones against resistant gram-positive pathogens. |
| AID528848 | Antimicrobial activity against methicillin-resistant Staphylococcus epidermidis assessed as resistant isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Antimicrobial-resistant pathogens in intensive care units in Canada: results of the Canadian National Intensive Care Unit (CAN-ICU) study, 2005-2006. |
| AID530814 | Antibacterial activity against Klebsiella pneumoniae 11978 harboring plasmid pA-1carrying beta-lactamase OXA-48 by Etest method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Plasmid-encoded carbapenem-hydrolyzing beta-lactamase OXA-48 in an imipenem-susceptible Klebsiella pneumoniae strain from Belgium. |
| AID373039 | Antimicrobial activity against imipenem and meropenem-resistant Acinetobacter baumannii isolate ZJ32 by CLSI agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Molecular epidemiology of clinical isolates of carbapenem-resistant Acinetobacter spp. from Chinese hospitals. |
| AID571218 | Antimicrobial activity against Pseudomonas aeruginosa isolate TX292 obtained from patient with non-cystic fibrosis by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Role of ampD homologs in overproduction of AmpC in clinical isolates of Pseudomonas aeruginosa. |
| AID544676 | Antimicrobial activity against Escherichia coli clinical isolate after 18 to 22 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Establishment of in vitro susceptibility testing methodologies and comparative activities of piperacillin in combination with the penem {beta}-lactamase inhibitor BLI-489. |
| AID373041 | Antimicrobial activity against imipenem and meropenem-resistant Acinetobacter baumannii isolate ZJ36 by CLSI agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Molecular epidemiology of clinical isolates of carbapenem-resistant Acinetobacter spp. from Chinese hospitals. |
| AID535720 | Activity of Escherichia coli TOP10 beta-lactamase AmpC-A | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Role of the Ser-287-Asn replacement in the hydrolysis spectrum extension of AmpC beta-lactamases in Escherichia coli. |
| AID556657 | Antimicrobial activity against multidrug resistant Enterobacter aerogenes isolate 12 by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Occurrence of efflux mechanism and cephalosporinase variant in a population of Enterobacter aerogenes and Klebsiella pneumoniae isolates producing extended-spectrum beta-lactamases. |
| AID528534 | Antimicrobial activity against penicillin-resistant Streptococcus agalactiae B503 by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | First molecular characterization of group B streptococci with reduced penicillin susceptibility. |
| AID530286 | Antimicrobial activity against PR-39-resistant Salmonella enterica serovar Typhimurium LT2 DA10899 harboring Q179Stop mutant gene by Etest | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Mechanism and fitness costs of PR-39 resistance in Salmonella enterica serovar Typhimurium LT2. |
| AID625290 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for liver fatty | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID529462 | Antimicrobial activity against Klebsiella pneumoniae isolate 11 expressing beta-lactamase Oxa-48, TEM-1 and Oxa-1 by Etest | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Spread of OXA-48-positive carbapenem-resistant Klebsiella pneumoniae isolates in Istanbul, Turkey. |
| AID285255 | Antimicrobial activity against Escherichia coli DH5-alpha CF1179 isolate expressing CMT and TEM1 by disk diffusion assay | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Evolution of TEM-type enzymes: biochemical and genetic characterization of two new complex mutant TEM enzymes, TEM-151 and TEM-152, from a single patient. |
| AID533764 | Antibacterial activity against OXA-19 producing Pseudomonas aeruginosa isolate P11 exhibiting PFGE A pattern by 2-fold agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | Nationwide investigation of extended-spectrum beta-lactamases, metallo-beta-lactamases, and extended-spectrum oxacillinases produced by ceftazidime-resistant Pseudomonas aeruginosa strains in France. |
| AID535704 | Antibacterial activity against Escherichia coli TOP10 expressing AmpC-A S287N mutant protein by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Role of the Ser-287-Asn replacement in the hydrolysis spectrum extension of AmpC beta-lactamases in Escherichia coli. |
| AID519188 | Antimicrobial activity against mexXY-OprM-overproducing Pseudomonas aeruginosa clinical isolate | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Relationship between antibiotic use and incidence of MexXY-OprM overproducers among clinical isolates of Pseudomonas aeruginosa. |
| AID562475 | Antimicrobial activity against rifampicin-resistant Escherichia coli A15 by Etest | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | Emergence of Klebsiella pneumoniae ST258 with KPC-2 in Poland. |
| AID516145 | Antibacterial activity against Pulsotype I Acinetobacter genomosp. 3 isolate 11 containing IMP-1, OXA-58, ADC-18, ISAba1, ISAba3, IS1008, intI1 genetic elements by broth micro dilution | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Molecular characterization of beta-lactamase genes and their genetic structures in Acinetobacter genospecies 3 isolates in Taiwan. |
| AID351197 | Antimicrobial activity against drug-resistant Acinetobacter baumannii producing PER1 beta-lactamase | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10 | Global challenge of multidrug-resistant Acinetobacter baumannii. |
| AID517950 | Antimicrobial activity against Proteus vulgaris by broth dilution method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli. |
| AID554384 | Antimicrobial activity against Pseudomonas aeruginosa PAO1 by twofold macrodilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Efflux unbalance in Pseudomonas aeruginosa isolates from cystic fibrosis patients. |
| AID522004 | Antimicrobial activity against Escherichia coli isolate J53 harboring p7A containing beta-lactamase OXA-48 located within transposon Tn1999 by Etest method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Spread of OXA-48-encoding plasmid in Turkey and beyond. |
| AID587523 | Antimicrobial activity against carbapenemases KPC-producing Klebsiella pneumoniae VA-361 infected in sc dosed CD-1 mouse in presence of 2 ug/ml NXL104 beta-lactamase inhibitor | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1 | Evaluation of ceftazidime and NXL104 in two murine models of infection due to KPC-producing Klebsiella pneumoniae. |
| AID524925 | Antimicrobial activity against Escherichia coli MI1443 harboring A77V mutation in beta lactamase CTX-M-10 by E-test | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Mutational events in cefotaximase extended-spectrum beta-lactamases of the CTX-M-1 cluster involved in ceftazidime resistance. |
| AID528967 | Antimicrobial activity against methicillin-susceptible Staphylococcus epidermidis isolated from ICU patient blood assessed as resistant isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Antimicrobial-resistant pathogens in intensive care units in Canada: results of the Canadian National Intensive Care Unit (CAN-ICU) study, 2005-2006. |
| AID521834 | Antibacterial activity against Klebsiella pneumoniae isolate VA367 with blaKPC-3, qnrB19, blaTEM-1, blaSHV-11, blaSHV-12, aac(6')-1b genes by CLSI method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Presence of plasmid-mediated quinolone resistance in Klebsiella pneumoniae isolates possessing blaKPC in the United States. |
| AID761213 | Antibacterial activity against Pseudomonas aeruginosa expressing metallo-beta-lactamase by broth microdilution method | 2013 | Journal of medicinal chemistry, Jul-11, Volume: 56, Issue:13 | Pyridone-conjugated monobactam antibiotics with gram-negative activity. |
| AID511288 | Antibacterial activity against Escherichia coli DH5alpha pB-ges-13 plasmid | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | GES-13, a beta-lactamase variant possessing Lys-104 and Asn-170 in Pseudomonas aeruginosa. |
| AID529649 | Antimicrobial activity against Escherichia coli DH5alpha harboring beta-lactamase VIM-16 by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | VIM-15 and VIM-16, two new VIM-2-like metallo-beta-lactamases in Pseudomonas aeruginosa isolates from Bulgaria and Germany. |
| AID563155 | Antibacterial activity against Pseudomonas aeruginosa isolate 9BR by Etest | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | Involvement of pmrAB and phoPQ in polymyxin B adaptation and inducible resistance in non-cystic fibrosis clinical isolates of Pseudomonas aeruginosa. |
| AID555676 | Antimicrobial activity against Escherichia coli DH5[alpha] harboring phagemid pBK-CMV by disk diffusion method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Novel plasmid-encoded ceftazidime-hydrolyzing CTX-M-53 extended-spectrum beta-lactamase from Salmonella enterica serotypes Westhampton and Senftenberg. |
| AID529663 | Activity of Pseudomonas aeruginosa 166301 beta-lactamase VIM-16 relative to cephaloridine | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | VIM-15 and VIM-16, two new VIM-2-like metallo-beta-lactamases in Pseudomonas aeruginosa isolates from Bulgaria and Germany. |
| AID545458 | Antimicrobial activity against Serratia marcescens assessed as percent susceptible isolates by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Susceptibility of gram-negative pathogens isolated from patients with complicated intra-abdominal infections in the United States, 2007-2008: results of the Study for Monitoring Antimicrobial Resistance Trends (SMART). |
| AID529904 | Antimicrobial activity against Leptospira interrogans serovar Canicola isolate 11 by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Antimicrobial susceptibilities of geographically diverse clinical human isolates of Leptospira. |
| AID533880 | Antibacterial activity against cefotaxime-intermediate Streptococcus pneumoniae isolate by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | In vitro activity of ceftaroline against Streptococcus pneumoniae isolates exhibiting resistance to penicillin, amoxicillin, and cefotaxime. |
| AID544909 | Antimicrobial activity against Proteus mirabilis clinical isolate after 18 to 22 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Establishment of in vitro susceptibility testing methodologies and comparative activities of piperacillin in combination with the penem {beta}-lactamase inhibitor BLI-489. |
| AID583028 | Antimicrobial activity against Escherichia coli TOP10 transformed with Escherichia coli pGLK-1 plasmid carrying FOX-1 by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Phenotypic and biochemical comparison of the carbapenem-hydrolyzing activities of five plasmid-borne AmpC β-lactamases. |
| AID524569 | Antimicrobial activity against Shigella isolate DH-22451 by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Identification and characterization of CTX-M-producing Shigella isolates in the United States. |
| AID368516 | Ratio of Kcat to Km of Pseudomonas aeruginosa IMP1 assessed as drug hydrolysis by spectrophotometry relative to cephaloridine | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID559272 | Antimicrobial activity against Proteus vulgaris Pv9 expressing beta-lactamase PER-1 by Etest | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Emergence of extended-spectrum beta-lactamase PER-1 in Proteus vulgaris and Providencia stuartii isolates from Algiers, Algeria. |
| AID583083 | Activity of Escherichia coli BL21(DE3) VIM-2 W87A mutant beta-lactamase by spectrophotometer | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | Mutational analysis of VIM-2 reveals an essential determinant for metallo-beta-lactamase stability and folding. |
| AID511289 | Antibacterial activity against Escherichia coli DH5alpha pB-ges-1 | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | GES-13, a beta-lactamase variant possessing Lys-104 and Asn-170 in Pseudomonas aeruginosa. |
| AID546168 | Antimicrobial activity against AmpC overproducing Pseudomonas aeruginosa isolate Pae-beta-08 with PDC-2 variant by Etest | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Extended-spectrum cephalosporinases in Pseudomonas aeruginosa. |
| AID583092 | Activity of Escherichia coli XL1-Blue VIM-2 A64W mutant beta-lactamase by spectrophotometer | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | Mutational analysis of VIM-2 reveals an essential determinant for metallo-beta-lactamase stability and folding. |
| AID588216 | FDA HLAED, serum glutamic oxaloacetic transaminase (SGOT) increase | 2004 | Current drug discovery technologies, Dec, Volume: 1, Issue:4 | Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. |
| AID522006 | Antimicrobial activity against Klebsiella pneumoniae isolate KpI-2 expressing beta-lactamase OXA-48 and CTX-M-15 by Etest method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Spread of OXA-48-encoding plasmid in Turkey and beyond. |
| AID372626 | Ratio of Kcat/Km for Escherichia coli DH5alpha beta-lactamase TEM-12 to Kcat/Km for Escherichia coli DH5alpha beta-lactamase TEM-158 | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | TEM-158 (CMT-9), a new member of the CMT-type extended-spectrum beta-lactamases. |
| AID394696 | Antibacterial activity against beta-lactams resistant Pseudomonas aeruginosa isolate expressing OXA2 by macrodilution technique | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10 | Pseudomonas aeruginosa may accumulate drug resistance mechanisms without losing its ability to cause bloodstream infections. |
| AID495662 | Ratio of Kcat to Km for Pseudomonas aeruginosa 531 beta-lactamase BEL-2 | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | BEL-2, an extended-spectrum beta-lactamase with increased activity toward expanded-spectrum cephalosporins in Pseudomonas aeruginosa. |
| AID541534 | Antimicrobial activity against Enterococcus faecium clinical isolate after 18 to 22 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Establishment of in vitro susceptibility testing methodologies and comparative activities of piperacillin in combination with the penem {beta}-lactamase inhibitor BLI-489. |
| AID560079 | Antimicrobial activity against Pseudomonas aeruginosa isolate 1019 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | In vitro activity of ceftaroline alone and in combination against clinical isolates of resistant gram-negative pathogens, including beta-lactamase-producing Enterobacteriaceae and Pseudomonas aeruginosa. |
| AID495661 | Activity at Pseudomonas aeruginosa 531 beta-lactamase BEL-2 | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | BEL-2, an extended-spectrum beta-lactamase with increased activity toward expanded-spectrum cephalosporins in Pseudomonas aeruginosa. |
| AID535722 | Activity of Escherichia coli TOP10 beta-lactamase AmpC-A S287N mutant | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Role of the Ser-287-Asn replacement in the hydrolysis spectrum extension of AmpC beta-lactamases in Escherichia coli. |
| AID279186 | Activity of Enterobacter cloacae S3 isolate beta lactamase LAP1 expressed in Escherichia coli DH10B | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2 | Novel Ambler class A beta-lactamase LAP-1 and its association with the plasmid-mediated quinolone resistance determinant QnrS1. |
| AID559276 | Antimicrobial activity against rifampin-resistant Escherichia coli J53 transconjugated with Proteus vulgaris Pv8 expressing beta-lactamase PER-1 by Etest | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Emergence of extended-spectrum beta-lactamase PER-1 in Proteus vulgaris and Providencia stuartii isolates from Algiers, Algeria. |
| AID528849 | Antimicrobial activity against methicillin-susceptible Staphylococcus epidermidis isolated from ICU patient respiratory tract assessed as resistant isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Antimicrobial-resistant pathogens in intensive care units in Canada: results of the Canadian National Intensive Care Unit (CAN-ICU) study, 2005-2006. |
| AID325189 | Antibacterial activity against Toho 2 producing Escherichia coli by standard serial agar dilution method | 2008 | Bioorganic & medicinal chemistry, Feb-15, Volume: 16, Issue:4 | A novel series of parenteral cephalosporins exhibiting potent activities against both Pseudomonas aeruginosa and other gram-negative pathogens. Part 2: Synthesis and structure-activity relationships. |
| AID582924 | Ratio of Kcat to Km for Escherichia coli BL21(DE3) VIM-2 W87A mutant beta-lactamase by spectrophotometer | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | Mutational analysis of VIM-2 reveals an essential determinant for metallo-beta-lactamase stability and folding. |
| AID558813 | Antimicrobial activity against Pseudomonas aeruginosa assessed as percent susceptible isolates by CLSI method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Emergence of high levels of extended-spectrum-beta-lactamase-producing gram-negative bacilli in the Asia-Pacific region: data from the Study for Monitoring Antimicrobial Resistance Trends (SMART) program, 2007. |
| AID556648 | Antimicrobial activity against multidrug resistant Enterobacter aerogenes isolate 3 by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Occurrence of efflux mechanism and cephalosporinase variant in a population of Enterobacter aerogenes and Klebsiella pneumoniae isolates producing extended-spectrum beta-lactamases. |
| AID285577 | Antimicrobial activity against Pseudomonas aeruginosa 65.18-4 tracheal isolates from mechanically ventilated tuberculosis patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID428266 | Antimicrobial activity against carbapenemase producing Enterobacteriaceae by CLSI broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | Antimicrobial activities of tigecycline and other broad-spectrum antimicrobials tested against serine carbapenemase- and metallo-beta-lactamase-producing Enterobacteriaceae: report from the SENTRY Antimicrobial Surveillance Program. |
| AID625289 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for liver disease | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID522021 | Antimicrobial activity against Enterobacter cloacae isolate 2 expressing beta-lactamase OXA-48 and SHV-5 by Etest method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Spread of OXA-48-encoding plasmid in Turkey and beyond. |
| AID559900 | Antimicrobial activity against Klebsiella pneumoniae 278 harboring beta-lactamase OXY-1 by Etest method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | First detection of plasmid-encoded blaOXY beta-lactamase. |
| AID495912 | Hydrolytic activity of beta-lactamase VIM-19 expressed in Escherichia coli TOP10 by spectrophotometry | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | VIM-19, a metallo-beta-lactamase with increased carbapenemase activity from Escherichia coli and Klebsiella pneumoniae. |
| AID544492 | Antibacterial activity against Escherichia coli TOP10 harboring beta-lactamase KPC-2 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Phenotypic and enzymatic comparative analysis of the novel KPC variant KPC-5 and its evolutionary variants, KPC-2 and KPC-4. |
| AID571922 | Antimicrobial activity against ISAba1 linked with the blaOXA-51-type beta-lactamase harboring Acinetobacter baumannii zeta clonal group isolate 25 expressing ampC, ompA, adeB, adeM, aadA1, aacA4, aacC2, blaSHV-5 by Etest method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Correlation of antimicrobial resistance with beta-lactamases, the OmpA-like porin, and efflux pumps in clinical isolates of Acinetobacter baumannii endemic to New York City. |
| AID1361174 | Antimicrobial activity against SHV-4 producing Escherichia coli ATCC BAA-200 in presence of human apo-transferrin by broth microdilution method | 2018 | European journal of medicinal chemistry, Jul-15, Volume: 155 | Cefiderocol (S-649266), A new siderophore cephalosporin exhibiting potent activities against Pseudomonas aeruginosa and other gram-negative pathogens including multi-drug resistant bacteria: Structure activity relationship. |
| AID565723 | Antibacterial activity against oprD, mexB, mexY and mexD expressing Pseudomonas aeruginosa isolate Paebeta-28 harboring A residue at 105 position in PDC- 7 by Etest method in presence of cloxacillin | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Molecular epidemiology and mechanisms of carbapenem resistance in Pseudomonas aeruginosa. |
| AID531783 | Antibacterial activity against Stenotrophomonas maltophilia obtained from complicated skin and skin structure infections by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro activity of ceftobiprole against pathogens from two phase 3 clinical trials of complicated skin and skin structure infections. |
| AID368498 | Activity of Enterobacter cloacae 4092 AmpC (E2) assessed as drug hydrolysis by spectrophotometry | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID561629 | Antimicrobial activity against ampD2-deficient Stenotrophomonas maltophilia KJ by twofold serial agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | AmpDI is involved in expression of the chromosomal L1 and L2 beta-lactamases of Stenotrophomonas maltophilia. |
| AID521991 | Antimicrobial activity against Klebsiella pneumoniae isolate Kp11978 expressing beta-lactamase OXA-48, SHV-2a and TEM-1 by Etest method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Spread of OXA-48-encoding plasmid in Turkey and beyond. |
| AID285643 | Antimicrobial activity against Pseudomonas aeruginosa 15G10 tracheal isolates from mechanically ventilated chronic respiratory insufficiency patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID567313 | Antimicrobial activity against SHV-12 ESBL producing Pseudomonas aeruginosa isolate 2204 isolated from burn patient by broth microdilution method in presence of beta-lactamase inhibitor clavulanic acid | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Acquisition of a transposon encoding extended-spectrum beta-lactamase SHV-12 by Pseudomonas aeruginosa isolates during the clinical course of a burn patient. |
| AID516143 | Antibacterial activity against Pulsotype B Acinetobacter genomosp. 3 isolate 8 containing IMP-1, OXA-58, ADC-18, ISAba1, ISAba3, IS1008, intI1 genetic elements by broth micro dilution | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Molecular characterization of beta-lactamase genes and their genetic structures in Acinetobacter genospecies 3 isolates in Taiwan. |
| AID531603 | Antimicrobial activity against Escherichia coli JM109 by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Molecular and biochemical characterization of SHV-56, a novel inhibitor-resistant beta-lactamase from Klebsiella pneumoniae. |
| AID522018 | Antimicrobial activity against Escherichia coli isolate TOP10 harboring pPR containing beta-lactamase and TEM-101 by Etest method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Spread of OXA-48-encoding plasmid in Turkey and beyond. |
| AID322322 | Antibacterial activity against Escherichia coli INSRA5905 isolates expressing CTX-M-15 and TEM-1B enzymes by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Spread of extended-spectrum beta-lactamase CTX-M-producing escherichia coli clinical isolates in community and nosocomial environments in Portugal. |
| AID559897 | Antimicrobial activity against Klebsiella oxytoca KO280 harboring beta-lactamase OXY-1 by Etest method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | First detection of plasmid-encoded blaOXY beta-lactamase. |
| AID519184 | Antimicrobial activity against MexXY-OprM-overproducing Pseudomonas aeruginosa PAO1 harboring MexY and MexZ mutant gene selected after 8 ug/ml of amikacin exposure | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Relationship between antibiotic use and incidence of MexXY-OprM overproducers among clinical isolates of Pseudomonas aeruginosa. |
| AID533567 | Antimicrobial activity against Pseudomonas aeruginosa isolate PA465 expressing VIM-2 beta-lactamase | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | First survey of metallo-beta-lactamases in clinical isolates of Pseudomonas aeruginosa in a German university hospital. |
| AID535640 | Antimicrobial activity against Group B streptococcus serotype Ib C2 harboring E63K mutation in PBP 2A and L41S mutation in PBP 1B by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | Genetic heterogeneity in pbp genes among clinically isolated group B Streptococci with reduced penicillin susceptibility. |
| AID546618 | Antimicrobial activity against Pseudomonas aeruginosa isolate 243-31C expressing beta-lactamase VIM-18 isolated from sputum of patient by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Carbapenem resistance among Pseudomonas aeruginosa strains from India: evidence for nationwide endemicity of multiple metallo-beta-lactamase clones (VIM-2, -5, -6, and -11 and the newly characterized VIM-18). |
| AID368732 | Ratio of Kcat to Km of Pseudomonas aeruginosa AmpC assessed as drug hydrolysis by spectrophotometry relative to cephaloridine | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID368533 | Ratio of Kcat to Km of Morganella morganii AmpC assessed as drug hydrolysis by spectrophotometry | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID498830 | Antimicrobial activity against carbapenem-resistant Enterobacter cloacae WH103 deficient in IMP-4, TEM-1, CTX-M-3, qnrS1, ompC by CLSI method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Phenotypic and genotypic characterization of Enterobacteriaceae with decreased susceptibility to carbapenems: results from large hospital-based surveillance studies in China. |
| AID373771 | Antibacterial activity against imipenem-resistant Acinetobacter baumannii abh29 by broth dilution method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | An OXA-66/OXA-51-like carbapenemase and possibly an efflux pump are associated with resistance to imipenem in Acinetobacter baumannii. |
| AID285268 | Activity of Escherichia coli BL21(DE3) beta-lactamase TEM152 | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Evolution of TEM-type enzymes: biochemical and genetic characterization of two new complex mutant TEM enzymes, TEM-151 and TEM-152, from a single patient. |
| AID499051 | Antimicrobial activity against carbapenem-resistant Escherichia coli PU60 deficient in TEM-1, CMY-2, ompC/F by CLSI method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Phenotypic and genotypic characterization of Enterobacteriaceae with decreased susceptibility to carbapenems: results from large hospital-based surveillance studies in China. |
| AID508292 | Antimicrobial activity against penicillin-resistant Enterococcus faecium D63r by microdilution method | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2 | Interaction of ceftobiprole with the low-affinity PBP 5 of Enterococcus faecium. |
| AID540945 | Antimicrobial activity against Escherichia coli DH5[alpha] transformant harboring pH205 plasmid expressing cephalosporinase CMY-36 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | CMY-31 and CMY-36 cephalosporinases encoded by ColE1-like plasmids. |
| AID549336 | Antimicrobial activity against Escherichia coli isolate 49 harboring bla CTX-M-3a gene by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | blaCTX-M genes in escherichia coli strains from Croatian Hospitals are located in new (blaCTX-M-3a) and widely spread (blaCTX-M-3a and blaCTX-M-15) genetic structures. |
| AID573363 | Antibacterial activity against ceftazidime-nonsusceptible Klebsiella pneumoniae assessed as resistant isolates by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID529582 | Ratio of Kcat to Km for Bradyrhizobium japonicum beta-Lactamase BJP-1 | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Functional diversity among metallo-beta-lactamases: characterization of the CAR-1 enzyme of Erwinia carotovora. |
| AID279814 | Antimicrobial activity against Escherichia coli DH5-alpha with pYW2 expressing KPC2 and TEM1 gene by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2 | Plasmid-mediated KPC-2 in a Klebsiella pneumoniae isolate from China. |
| AID583025 | Antimicrobial activity against Escherichia coli TOP10 transformed by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Phenotypic and biochemical comparison of the carbapenem-hydrolyzing activities of five plasmid-borne AmpC β-lactamases. |
| AID531313 | Activity of Pseudomonas aeruginosa beta-lactamase VIM-7 by spectrophotometry | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Kinetic characterization of VIM-7, a divergent member of the VIM metallo-beta-lactamase family. |
| AID520721 | Antibacterial activity against Escherichia coli DH10B harboring pOXA-97 | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Carbapenem-resistant Acinetobacter baumannii isolates from Tunisia producing the OXA-58-like carbapenem-hydrolyzing oxacillinase OXA-97. |
| AID534662 | Antimicrobial activity against Non-ESBL Proteus mirabilis by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activity of doripenem, a carbapenem for the treatment of challenging infections caused by gram-negative bacteria, against recent clinical isolates from the United States. |
| AID528820 | Antimicrobial activity against carbapenem-resistant Pseudomonas aeruginosa isolated from ICU patient respiratory tract assessed as resistant isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Antimicrobial-resistant pathogens in intensive care units in Canada: results of the Canadian National Intensive Care Unit (CAN-ICU) study, 2005-2006. |
| AID573348 | Antibacterial activity against ceftazidime-susceptible Enterobacter cloacae assessed as resistant isolates by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID529461 | Antimicrobial activity against Escherichia coli J53 by Etest | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Spread of OXA-48-positive carbapenem-resistant Klebsiella pneumoniae isolates in Istanbul, Turkey. |
| AID534929 | Antimicrobial activity against Ceftazidime non-susceptible Serratia marcescens assessed as resistant isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activity of doripenem, a carbapenem for the treatment of challenging infections caused by gram-negative bacteria, against recent clinical isolates from the United States. |
| AID572138 | Antimicrobial activity against Acinetobacter baumannii eta clonal group isolate 36 expressing ampC, ompA, adeB, adeM by Etest method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Correlation of antimicrobial resistance with beta-lactamases, the OmpA-like porin, and efflux pumps in clinical isolates of Acinetobacter baumannii endemic to New York City. |
| AID424859 | Antimicrobial activity against Pseudomonas aeruginosa PAO1 by E-test | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Molecular epidemiology and mechanisms of carbapenem resistance in Pseudomonas aeruginosa isolates from Spanish hospitals. |
| AID522007 | Antimicrobial activity against Escherichia coli isolate J53 harboring pI-1 containing beta-lactamase OXA-48 located within transposon Tn1999.2 by Etest method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Spread of OXA-48-encoding plasmid in Turkey and beyond. |
| AID567318 | Antimicrobial activity against Escherichia coli TUM4670 by broth dilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Chromosomally encoded blaCMY-2 located on a novel SXT/R391-related integrating conjugative element in a Proteus mirabilis clinical isolate. |
| AID571910 | Antimicrobial activity against ISAba1 linked with the blaOXA-51-type beta-lactamase harboring Acinetobacter baumannii zeta clonal group isolate 19 expressing ampC, ompA, adeB, adeM, aacC2 by Etest method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Correlation of antimicrobial resistance with beta-lactamases, the OmpA-like porin, and efflux pumps in clinical isolates of Acinetobacter baumannii endemic to New York City. |
| AID565522 | Antibacterial activity against mexB, mexY and mexD expressing Pseudomonas aeruginosa isolate Paebeta-13 harboring A residue at 105 position in PDC- 2 and polymorphic OprD gene by Etest method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Molecular epidemiology and mechanisms of carbapenem resistance in Pseudomonas aeruginosa. |
| AID283542 | Antibacterial activity against Pseudomonas aeruginosa FE57GU with inactivated rplY, nuoG and galU genes by microdilution method | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3 | Cumulative effects of several nonenzymatic mechanisms on the resistance of Pseudomonas aeruginosa to aminoglycosides. |
| AID560134 | Activity of recombinant beta-lactamase RTG4 expressed in Escherichia coli TOP10 assessed as Ratio of Kcat to Km by nitrocefin hydrolysis assay relative to benzylpenicillin | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Genetic and biochemical characterization of the first extended-spectrum CARB-type beta-lactamase, RTG-4, from Acinetobacter baumannii. |
| AID521425 | Antibacterial activity against Stenotrophomonas maltophilia isolate KJ by Etest | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Induction of L1 and L2 beta-lactamases of Stenotrophomonas maltophilia. |
| AID544491 | Antibacterial activity against Escherichia coli TOP10 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Phenotypic and enzymatic comparative analysis of the novel KPC variant KPC-5 and its evolutionary variants, KPC-2 and KPC-4. |
| AID1318919 | Antibacterial activity against multidrug/extremely drug-resistant/colistin-susceptible Pseudomonas aeruginosa isolate 101885 | 2016 | Journal of medicinal chemistry, 09-22, Volume: 59, Issue:18 | Hybrid Antibiotic Overcomes Resistance in P. aeruginosa by Enhancing Outer Membrane Penetration and Reducing Efflux. |
| AID368514 | Activity of Pseudomonas aeruginosa VIM2 assessed as drug hydrolysis by spectrophotometry | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID565770 | Antimicrobial activity against Pseudomonas aeruginosa OC 12070 expressing 12 fold elevated mexX expression and 25 fold elevated mexY expression by broth macrodilution method | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | Differential selection of single-step AmpC or efflux mutants of Pseudomonas aeruginosa by using cefepime, ceftazidime, or ceftobiprole. |
| AID531972 | Antibacterial activity against Klebsiella pneumoniae blood isolate A28006 PFGE pattern A expressing KPC-2, TEM-1, SHV-11, CTX-M-2 beta-lactamase by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | First report of KPC-2-producing Klebsiella pneumoniae strains in Brazil. |
| AID559274 | Antimicrobial activity against rifampin-resistant Escherichia coli J53 transconjugated with Proteus vulgaris Pv5 expressing beta-lactamase PER-1 by Etest | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Emergence of extended-spectrum beta-lactamase PER-1 in Proteus vulgaris and Providencia stuartii isolates from Algiers, Algeria. |
| AID285632 | Antimicrobial activity against Pseudomonas aeruginosa 10A9 tracheal isolates from mechanically ventilated chronic respiratory insufficiency patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID528975 | Antimicrobial activity against methicillin-susceptible Staphylococcus aureus isolated from ICU patient wound assessed as resistant isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Antimicrobial-resistant pathogens in intensive care units in Canada: results of the Canadian National Intensive Care Unit (CAN-ICU) study, 2005-2006. |
| AID588217 | FDA HLAED, serum glutamic pyruvic transaminase (SGPT) increase | 2004 | Current drug discovery technologies, Dec, Volume: 1, Issue:4 | Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. |
| AID534900 | Antimicrobial activity against Citrobacter with derepressed AmpC beta-lactamsae by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activity of doripenem, a carbapenem for the treatment of challenging infections caused by gram-negative bacteria, against recent clinical isolates from the United States. |
| AID544677 | Antimicrobial activity against class A extended spectrum beta-lactamase- producing Escherichia coli clinical isolate after 18 to 22 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Establishment of in vitro susceptibility testing methodologies and comparative activities of piperacillin in combination with the penem {beta}-lactamase inhibitor BLI-489. |
| AID544930 | Antimicrobial activity against Acinetobacter johnsonii clinical isolate after 18 to 22 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Establishment of in vitro susceptibility testing methodologies and comparative activities of piperacillin in combination with the penem {beta}-lactamase inhibitor BLI-489. |
| AID528531 | Antimicrobial activity against penicillin-resistant Streptococcus agalactiae B60 by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | First molecular characterization of group B streptococci with reduced penicillin susceptibility. |
| AID587731 | Ratio of Kcat to Km for Pseudomonas aeruginosa strain PS 297 metallo-beta-lactamase IMP18 expressed in Escherichia coli BL21(DE3) assessed as substrate hydrolysis using 100 uM nitrocefin | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1 | Genetic context and biochemical characterization of the IMP-18 metallo-beta-lactamase identified in a Pseudomonas aeruginosa isolate from the United States. |
| AID499047 | Antimicrobial activity against carbapenem-resistant Klebsiella pneumoniae ZJ69 deficient in SHV-28, ompK35/36 by CLSI method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Phenotypic and genotypic characterization of Enterobacteriaceae with decreased susceptibility to carbapenems: results from large hospital-based surveillance studies in China. |
| AID561666 | Antimicrobial activity against Pseudomonas aeruginosa PAO1 harboring plasmid MexXY expressing mexXY gene by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Effect of MexXY overexpression on ceftobiprole susceptibility in Pseudomonas aeruginosa. |
| AID524742 | Antimicrobial activity against Escherichia coli GB20 harboring P167S mutation in beta lactamase CTX-M-10 by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Mutational events in cefotaximase extended-spectrum beta-lactamases of the CTX-M-1 cluster involved in ceftazidime resistance. |
| AID573200 | Antimicrobial activity against mutS::lox-deficient Pseudomonas aeruginosa PAOMSA biofilm harboring nfxB C116T mutant gene selected at 1 ug/ml of azithromycin after 1 passages by Etest method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Azithromycin in Pseudomonas aeruginosa biofilms: bactericidal activity and selection of nfxB mutants. |
| AID529651 | Antimicrobial activity against Escherichia coli DH5alpha harboring beta-lactamase VIM-2 by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | VIM-15 and VIM-16, two new VIM-2-like metallo-beta-lactamases in Pseudomonas aeruginosa isolates from Bulgaria and Germany. |
| AID541519 | Antimicrobial activity against methicillin-susceptible Staphylococcus aureus clinical isolate after 18 to 22 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Establishment of in vitro susceptibility testing methodologies and comparative activities of piperacillin in combination with the penem {beta}-lactamase inhibitor BLI-489. |
| AID544961 | Antimicrobial activity against Klebsiella pneumoniae expressing beta-lactamase CTX by Etest based on single determinant | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Characterization and sequence analysis of extended-spectrum-{beta}-lactamase-encoding genes from Escherichia coli, Klebsiella pneumoniae, and Proteus mirabilis isolates collected during tigecycline phase 3 clinical trials. |
| AID522009 | Antimicrobial activity against Klebsiella pneumoniae isolate KpBIC expressing beta-lactamase OXA-48 by Etest method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Spread of OXA-48-encoding plasmid in Turkey and beyond. |
| AID565726 | Antibacterial activity against oprD, mexB, mexY and mexD expressing Pseudomonas aeruginosa isolate Paebeta-31 harboring A residue at 105 position in PDC- 9 by Etest method in presence of cloxacillin | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Molecular epidemiology and mechanisms of carbapenem resistance in Pseudomonas aeruginosa. |
| AID571920 | Antimicrobial activity against ISAba1 linked with the blaOXA-51-type beta-lactamase harboring Acinetobacter baumannii zeta clonal group isolate 24 expressing ampC, ompA, adeB, adeM, aadA1, aacA4, aacC2, blaSHV-5 by Etest method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Correlation of antimicrobial resistance with beta-lactamases, the OmpA-like porin, and efflux pumps in clinical isolates of Acinetobacter baumannii endemic to New York City. |
| AID535140 | Antimicrobial activity against imipenem susceptible Pseudomonas aeruginosa assessed as susceptible isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activity of doripenem, a carbapenem for the treatment of challenging infections caused by gram-negative bacteria, against recent clinical isolates from the United States. |
| AID529581 | Ratio of Kcat to Km for Janthinobacterium lividum THIN-B | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Functional diversity among metallo-beta-lactamases: characterization of the CAR-1 enzyme of Erwinia carotovora. |
| AID528822 | Antimicrobial activity against carbapenem-resistant Pseudomonas aeruginosa isolated from ICU patient urine assessed as resistant isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Antimicrobial-resistant pathogens in intensive care units in Canada: results of the Canadian National Intensive Care Unit (CAN-ICU) study, 2005-2006. |
| AID582979 | Antimicrobial activity against ampR::lox gene-deficient Pseudomonas aeruginosa PAO1 by Etest method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | NagZ inactivation prevents and reverts beta-lactam resistance, driven by AmpD and PBP 4 mutations, in Pseudomonas aeruginosa. |
| AID544493 | Antibacterial activity against Escherichia coli TOP10 harboring beta-lactamase KPC-4 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Phenotypic and enzymatic comparative analysis of the novel KPC variant KPC-5 and its evolutionary variants, KPC-2 and KPC-4. |
| AID565714 | Antibacterial activity against oprD, mexB, mexY and mexD expressing Pseudomonas aeruginosa isolate Paebeta-19 harboring A residue at 105 position in PDC- 3 and wild type OprD gene by Etest method in presence of cloxacillin | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Molecular epidemiology and mechanisms of carbapenem resistance in Pseudomonas aeruginosa. |
| AID394496 | Antimicrobial activity against Escherichia coli MC4100 harboring pB-acc1 plasmid by agar dilution technique | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10 | Plasmid-encoded ACC-4, an extended-spectrum cephalosporinase variant from Escherichia coli. |
| AID544900 | Antimicrobial activity against Klebsiella oxytoca clinical isolate after 18 to 22 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Establishment of in vitro susceptibility testing methodologies and comparative activities of piperacillin in combination with the penem {beta}-lactamase inhibitor BLI-489. |
| AID558046 | Antimicrobial activity against blaKPC-positive Klebsiella pneumoniae S9 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Genetic organization of transposase regions surrounding blaKPC carbapenemase genes on plasmids from Klebsiella strains isolated in a New York City hospital. |
| AID583639 | Cmin in febrile neutropenic patient with GFR of >70 ml/min at 2 g administered as 30 mins infusion every 8 hrs measured after 4 days by HPLC analysis | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | High cefepime plasma concentrations and neurological toxicity in febrile neutropenic patients with mild impairment of renal function. |
| AID534909 | Antimicrobial activity against Citrobacter with derepressed AmpC beta-lactamsae assessed as resistant isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activity of doripenem, a carbapenem for the treatment of challenging infections caused by gram-negative bacteria, against recent clinical isolates from the United States. |
| AID519663 | Antimicrobial activity against Escherichia coli Irk1224 harboring beta-lactamase CTX-M-3 by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Convergent in vivo and in vitro selection of ceftazidime resistance mutations at position 167 of CTX-M-3 beta-lactamase in hypermutable Escherichia coli strains. |
| AID405090 | Antimicrobial activity against integron carrying Enterobacteriaceae assessed as percent resistant isolates | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | Enterobacteriaceae bloodstream infections: presence of integrons, risk factors, and outcome. |
| AID543433 | Ratio of Kcat to km for Shigella sonnei UIH-1 CTX-M-64 | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Novel chimeric beta-lactamase CTX-M-64, a hybrid of CTX-M-15-like and CTX-M-14 beta-lactamases, found in a Shigella sonnei strain resistant to various oxyimino-cephalosporins, including ceftazidime. |
| AID516140 | Antibacterial activity against Pulsotype M Acinetobacter genomosp. 3 isolate 5 containing IMP-1, OXA-58, ADC-43, ISAba2, ISAba3, IS1008, intI1 genetic elements by broth micro dilution | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Molecular characterization of beta-lactamase genes and their genetic structures in Acinetobacter genospecies 3 isolates in Taiwan. |
| AID368481 | Antibacterial activity against Morganella morganii 2574 producing beta lactamase AmpC by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID544960 | Antimicrobial activity against Klebsiella pneumoniae expressing beta-lactamase SHV by Etest based on multiple determinants | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Characterization and sequence analysis of extended-spectrum-{beta}-lactamase-encoding genes from Escherichia coli, Klebsiella pneumoniae, and Proteus mirabilis isolates collected during tigecycline phase 3 clinical trials. |
| AID535870 | Antimicrobial activity against aac(6')-Ib-cr-negative Enterobacter cloacae GZ51T harboring qnrA gene by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | High prevalence of plasmid-mediated quinolone resistance genes qnr and aac(6')-Ib-cr in clinical isolates of Enterobacteriaceae from nine teaching hospitals in China. |
| AID508734 | Antibacterial activity against Pseudomonas aeruginosa PAO1 by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2 | Activity of a new antipseudomonal cephalosporin, CXA-101 (FR264205), against carbapenem-resistant and multidrug-resistant Pseudomonas aeruginosa clinical strains. |
| AID1139544 | Antibacterial activity against Escherichia coli DH5alpha expressing beta-lactamase NDM-1 by CLSI broth microdilution method | 2014 | Journal of medicinal chemistry, May-08, Volume: 57, Issue:9 | Siderophore receptor-mediated uptake of lactivicin analogues in gram-negative bacteria. |
| AID530288 | Antimicrobial activity against PR-39-resistant Salmonella enterica serovar Typhimurium LT2 DA6192 by Etest | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Mechanism and fitness costs of PR-39 resistance in Salmonella enterica serovar Typhimurium LT2. |
| AID532175 | Antimicrobial activity against aac(6')-Ib-cr-negative Enterobacter cloacae SH39T harboring qnrA gene by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | High prevalence of plasmid-mediated quinolone resistance genes qnr and aac(6')-Ib-cr in clinical isolates of Enterobacteriaceae from nine teaching hospitals in China. |
| AID285679 | Antimicrobial activity against Pseudomonas aeruginosa 29G7 tracheal isolates from mechanically ventilated chronic respiratory insufficiency patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID565535 | Antibacterial activity against oprD, mexB, mexY and mexD expressing Pseudomonas aeruginosa isolate Paebeta-31 harboring A residue at 105 position in PDC- 9 by Etest method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Molecular epidemiology and mechanisms of carbapenem resistance in Pseudomonas aeruginosa. |
| AID535059 | Antimicrobial activity against Acinetobacter genomic species 13TU by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | Contribution of a plasmid-borne blaOXA-58 gene with its hybrid promoter provided by IS1006 and an ISAba3-like element to beta-lactam resistance in acinetobacter genomic species 13TU. |
| AID518523 | Antimicrobial activity against Escherichia coli TOP10 after 2 days by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Characterization of CSP-1, a novel extended-spectrum beta-lactamase produced by a clinical isolate of Capnocytophaga sputigena. |
| AID544955 | Antimicrobial activity against Klebsiella pneumoniae extended-spectrum beta-lactamase producing isolate by Etest | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Characterization and sequence analysis of extended-spectrum-{beta}-lactamase-encoding genes from Escherichia coli, Klebsiella pneumoniae, and Proteus mirabilis isolates collected during tigecycline phase 3 clinical trials. |
| AID534919 | Antimicrobial activity against Ceftazidime susceptible Serratia marcescens by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activity of doripenem, a carbapenem for the treatment of challenging infections caused by gram-negative bacteria, against recent clinical isolates from the United States. |
| AID546410 | Antimicrobial activity against AmpC overproducing Pseudomonas aeruginosa isolate Pae-beta-27 with PDC-7 variant by Etest | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Extended-spectrum cephalosporinases in Pseudomonas aeruginosa. |
| AID540212 | Mean residence time in human after iv administration | 2008 | Drug metabolism and disposition: the biological fate of chemicals, Jul, Volume: 36, Issue:7 | Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. |
| AID528825 | Antimicrobial activity against ESBL producing Klebsiella pneumoniae isolated from ICU patient respiratory tract assessed as resistant isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Antimicrobial-resistant pathogens in intensive care units in Canada: results of the Canadian National Intensive Care Unit (CAN-ICU) study, 2005-2006. |
| AID520969 | Antibacterial activity against Klebsiella pneumoniae GR by Etest method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Genetic structures at the origin of acquisition of the beta-lactamase bla KPC gene. |
| AID1079935 | Cytolytic liver toxicity, either proven histopathologically or where the ratio of maximal ALT or AST activity above normal to that of Alkaline Phosphatase is > 5 (see ACUTE). Value is number of references indexed. [column 'CYTOL' in source] | |||
| AID535164 | Antimicrobial activity against imipenem non-susceptible Acinetobacter by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activity of doripenem, a carbapenem for the treatment of challenging infections caused by gram-negative bacteria, against recent clinical isolates from the United States. |
| AID498839 | Antimicrobial activity against carbapenem-resistant Klebsiella pneumoniae GZ66 deficient in SHV-11, DHA-1, ompK35/36 by CLSI method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Phenotypic and genotypic characterization of Enterobacteriaceae with decreased susceptibility to carbapenems: results from large hospital-based surveillance studies in China. |
| AID586085 | Antimicrobial activity against verocytotoxin-producing Escherichia coli isolate O157 obtained from human assessed as percentage of resistant isolates by disk diffusion method | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Antimicrobial resistance testing of verocytotoxin-producing Escherichia coli and first description of TEM-52 extended-spectrum β-lactamase in serogroup O26. |
| AID517960 | Antimicrobial activity against Burkholderia sp. by broth dilution method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli. |
| AID520382 | Antimicrobial activity Escherichia coli DH5alpha harboring bacteriophage T4 plasmid alpha omega by agar macrodilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Biochemical characterization of metallo-beta-lactamase VIM-11 from a Pseudomonas aeruginosa clinical strain. |
| AID573364 | Antibacterial activity against ceftazidime-susceptible Morganella morganii by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID535371 | Antimicrobial activity against Pseudomonas aeruginosa isolated from non-ICU patient assessed as resistant isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activity of doripenem, a carbapenem for the treatment of challenging infections caused by gram-negative bacteria, against recent clinical isolates from the United States. |
| AID554440 | Ratio of MIC for Pseudomonas aeruginosa 2933 to MIC for Pseudomonas aeruginosa PAO1 | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Efflux unbalance in Pseudomonas aeruginosa isolates from cystic fibrosis patients. |
| AID565532 | Antibacterial activity against mexB, mexY and mexD expressing Pseudomonas aeruginosa isolate Paebeta-03 harboring A residue at 105 position in PDC- 2 and polymorphic OprD gene by Etest method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Molecular epidemiology and mechanisms of carbapenem resistance in Pseudomonas aeruginosa. |
| AID517948 | Antimicrobial activity against Citrobacter freundii by broth dilution method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli. |
| AID529661 | Activity of Pseudomonas aeruginosa 9551 beta-lactamase VIM-15 relative to cephaloridine | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | VIM-15 and VIM-16, two new VIM-2-like metallo-beta-lactamases in Pseudomonas aeruginosa isolates from Bulgaria and Germany. |
| AID285611 | Antimicrobial activity against Pseudomonas aeruginosa 65.68-3 tracheal isolates from mechanically ventilated tuberculosis patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID574425 | Antimicrobial activity against Escherichia coli isolate 339 expressing beta-lactamase KPC2, TEM and PFGE cluster 5 isolated from peritoneal fluid of patient by vitek-2 method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Carbapenem-resistant KPC-2-producing Escherichia coli in a Tel Aviv Medical Center, 2005 to 2008. |
| AID542584 | Antimicrobial activity against Acinetobacter radioresistens 251-39C expressing beta-lactamase OXA-133 by CLSI method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Codetection of blaOXA-23-like gene (blaOXA-133) and blaOXA-58 in Acinetobacter radioresistens: report from the SENTRY antimicrobial surveillance program. |
| AID567749 | Antimicrobial activity against Pseudomonas aeruginosa OC 11678 expressing 31 fold elevated mexX expression and 17 fold elevated mexY expression by broth macrodilution method | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | Differential selection of single-step AmpC or efflux mutants of Pseudomonas aeruginosa by using cefepime, ceftazidime, or ceftobiprole. |
| AID517957 | Antimicrobial activity against Proteus mirabilis by broth dilution method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli. |
| AID531583 | Antibacterial activity against Enterobacter cloacae obtained from complicated skin and skin structure infections by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro activity of ceftobiprole against pathogens from two phase 3 clinical trials of complicated skin and skin structure infections. |
| AID565547 | Antibacterial activity against mexB, mexY and mexD expressing Pseudomonas aeruginosa isolate Paebeta-11 harboring A residue at 105 position in PDC- 2 and insertion of ISPa27 sequence in OprD gene by Etest method in presence of cloxacillin | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Molecular epidemiology and mechanisms of carbapenem resistance in Pseudomonas aeruginosa. |
| AID1373311 | Antimicrobial activity against Escherichia coli expressing beta-lactamase DHA by CLSI broth microdilution method | 2018 | Bioorganic & medicinal chemistry letters, 02-15, Volume: 28, Issue:4 | Optimization of novel monobactams with activity against carbapenem-resistant Enterobacteriaceae - Identification of LYS228. |
| AID533758 | Antibacterial activity against PER-1 producing Pseudomonas aeruginosa isolate P170 exhibiting PFGE G pattern by 2-fold agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | Nationwide investigation of extended-spectrum beta-lactamases, metallo-beta-lactamases, and extended-spectrum oxacillinases produced by ceftazidime-resistant Pseudomonas aeruginosa strains in France. |
| AID565767 | Antimicrobial activity against Pseudomonas aeruginosa OC 12070 expressing 5 fold elevated AmpC expression by broth macrodilution method | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | Differential selection of single-step AmpC or efflux mutants of Pseudomonas aeruginosa by using cefepime, ceftazidime, or ceftobiprole. |
| AID499121 | Antimicrobial activity against Pseudomonas aeruginosa OC 4351 infected in immunocompromized SKH1 mouse assessed as lesion volume at 100 mg/kg/day, sc measured after 48 hrs postinfection (Rvb = 2234 mm3) | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vivo activity of ceftobiprole in murine skin infections due to Staphylococcus aureus and Pseudomonas aeruginosa. |
| AID544533 | Antimicrobial activity against Escherichia coli DH5[alpha] isolate GC 8130 expressing bla SHV-1 gene by microdilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Pyrosequencing using the single-nucleotide polymorphism protocol for rapid determination of TEM- and SHV-type extended-spectrum beta-lactamases in clinical isolates and identification of the novel beta-lactamase genes blaSHV-48, blaSHV-105, and blaTEM-155 |
| AID394685 | Antibacterial activity against wild type Pseudomonas aeruginosa isolate by macrodilution technique | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10 | Pseudomonas aeruginosa may accumulate drug resistance mechanisms without losing its ability to cause bloodstream infections. |
| AID368494 | Ratio of Kcat to Km of Escherichia coli CTX-M-15 assessed as drug hydrolysis by spectrophotometry | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID518462 | Antimicrobial activity against Enterobacter cloacae S9369 assessed as number of passages required for MIC to rise above 4 times original MIC | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli. |
| AID545655 | Antimicrobial activity against Stenotrophomonas maltophilia assessed as percent susceptible isolates by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Susceptibility of gram-negative pathogens isolated from patients with complicated intra-abdominal infections in the United States, 2007-2008: results of the Study for Monitoring Antimicrobial Resistance Trends (SMART). |
| AID556665 | Antimicrobial activity against multidrug resistant Enterobacter aerogenes isolate 20 by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Occurrence of efflux mechanism and cephalosporinase variant in a population of Enterobacter aerogenes and Klebsiella pneumoniae isolates producing extended-spectrum beta-lactamases. |
| AID531781 | Antibacterial activity against Acinetobacter baumannii obtained from complicated skin and skin structure infections by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro activity of ceftobiprole against pathogens from two phase 3 clinical trials of complicated skin and skin structure infections. |
| AID301090 | Antibacterial activity against Haemophilus influenzae ATCC 49766 after 20 hrs by agar dilution method | 2007 | Bioorganic & medicinal chemistry, Nov-01, Volume: 15, Issue:21 | A novel series of parenteral cephalosporins exhibiting potent activities against Pseudomonas aeruginosa and other Gram-negative pathogens: synthesis and structure-activity relationships. |
| AID394695 | Antibacterial activity against beta-lactams resistant Pseudomonas aeruginosa isolate expressing AmpC, MexXY-OprM pump, TEM-2 by macrodilution technique | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10 | Pseudomonas aeruginosa may accumulate drug resistance mechanisms without losing its ability to cause bloodstream infections. |
| AID576062 | Antimicrobial activity against ESBL-positive Klebsiella pneumoniae 71697 harboring porin OmpK36V mutant gene by Etest | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | An ertapenem-resistant extended-spectrum-beta-lactamase-producing Klebsiella pneumoniae clone carries a novel OmpK36 porin variant. |
| AID1079947 | Comments (NB not yet translated). [column 'COMMENTAIRES' in source] | |||
| AID573334 | Antibacterial activity against ceftazidime-susceptible Enterobacteriaceae by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID498823 | Antimicrobial activity against Klebsiella pneumoniae WH77T expressing IMP-4, TEM-1, CTX-M-3, qnrS1 by CLSI method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Phenotypic and genotypic characterization of Enterobacteriaceae with decreased susceptibility to carbapenems: results from large hospital-based surveillance studies in China. |
| AID531589 | Antibacterial activity against Proteus vulgaris obtained from complicated skin and skin structure infections by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro activity of ceftobiprole against pathogens from two phase 3 clinical trials of complicated skin and skin structure infections. |
| AID573349 | Antibacterial activity against ceftazidime-nonsusceptible Enterobacter cloacae by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID576302 | Antimicrobial activity against ESBL-positive Klebsiella pneumoniae 26077 harboring porin OmpK36V mutant gene by Etest | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | An ertapenem-resistant extended-spectrum-beta-lactamase-producing Klebsiella pneumoniae clone carries a novel OmpK36 porin variant. |
| AID405819 | Antimicrobial activity against Acinetobacter sp. 5227 isolate harboring bla IMP-1 carrying integron In86 containing aminoglycoside resistance gene aac(6')-3 | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | Characterization of an integron carrying blaIMP-1 and a new aminoglycoside resistance gene, aac(6')-31, and its dissemination among genetically unrelated clinical isolates in a Brazilian hospital. |
| AID1139547 | Antibacterial activity against Escherichia coli DH5alpha expressing beta-lactamase KPC-3 by CLSI broth microdilution method | 2014 | Journal of medicinal chemistry, May-08, Volume: 57, Issue:9 | Siderophore receptor-mediated uptake of lactivicin analogues in gram-negative bacteria. |
| AID524933 | Antimicrobial activity against Escherichia coli MI1443 harboring V27A, Q38R, A77V mutations in beta lactamase CTX-M-3 by E-test | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Mutational events in cefotaximase extended-spectrum beta-lactamases of the CTX-M-1 cluster involved in ceftazidime resistance. |
| AID1361165 | Antimicrobial activity against Pseudomonas aeruginosa SR24 in presence of human apo-transferrin by broth microdilution method | 2018 | European journal of medicinal chemistry, Jul-15, Volume: 155 | Cefiderocol (S-649266), A new siderophore cephalosporin exhibiting potent activities against Pseudomonas aeruginosa and other gram-negative pathogens including multi-drug resistant bacteria: Structure activity relationship. |
| AID495904 | Antimicrobial activity in Klebsiella pneumoniae DIH-2 clinical isolate expressing beta-lactamase VIM-19 by Etest | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | VIM-19, a metallo-beta-lactamase with increased carbapenemase activity from Escherichia coli and Klebsiella pneumoniae. |
| AID428274 | Antimicrobial activity against carbapenemase producing Enterobacter sp. assessed as resistant isolates by CLSI breakpoint assay | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | Antimicrobial activities of tigecycline and other broad-spectrum antimicrobials tested against serine carbapenemase- and metallo-beta-lactamase-producing Enterobacteriaceae: report from the SENTRY Antimicrobial Surveillance Program. |
| AID573207 | Antimicrobial activity against mutS::lox-deficient Pseudomonas aeruginosa PAOMSA biofilm harboring nfxB G461A mutant gene selected at 4 ug/ml of azithromycin after 5 passages by Etest method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Azithromycin in Pseudomonas aeruginosa biofilms: bactericidal activity and selection of nfxB mutants. |
| AID541543 | Antimicrobial activity against Enterococcus avium clinical isolate after 18 to 22 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Establishment of in vitro susceptibility testing methodologies and comparative activities of piperacillin in combination with the penem {beta}-lactamase inhibitor BLI-489. |
| AID373752 | Antibacterial activity against imipenem-susceptible Acinetobacter baumannii ab3 by broth dilution method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | An OXA-66/OXA-51-like carbapenemase and possibly an efflux pump are associated with resistance to imipenem in Acinetobacter baumannii. |
| AID405453 | Antibacterial activity against Pseudomonas aeruginosa PAOdeltamutS by Etest | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | Influence of high mutation rates on the mechanisms and dynamics of in vitro and in vivo resistance development to single or combined antipseudomonal agents. |
| AID547534 | Antimicrobial activity against invasive Streptococcus anginosus obtained from non-cystic fibrosis patient assessed as non-susceptible isolates grown on mueller-Hinton blood agar at 30 ug/ml after 24 hrs at 37 degC by disk diffusion method in presence of 5 | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Macrolide and clindamycin resistance in Streptococcus milleri group isolates from the airways of cystic fibrosis patients. |
| AID531976 | Antibacterial activity against Escherichia coli DH10B expressing KPC-2 CTX-M-2 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | First report of KPC-2-producing Klebsiella pneumoniae strains in Brazil. |
| AID499050 | Antimicrobial activity against Klebsiella pneumoniae PU104T expressing TEM-1, CTX-M-15 by CLSI method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Phenotypic and genotypic characterization of Enterobacteriaceae with decreased susceptibility to carbapenems: results from large hospital-based surveillance studies in China. |
| AID498827 | Antimicrobial activity against Citrobacter freundii SZ63T expressing IMP-4, qnrS1by CLSI method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Phenotypic and genotypic characterization of Enterobacteriaceae with decreased susceptibility to carbapenems: results from large hospital-based surveillance studies in China. |
| AID498872 | Antimicrobial activity against Acinetobacter baumannii B9 containing carbapenemase blaOXA-23 gene assessed as growth inhibition by Etest method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | First isolation of the blaOXA-23 carbapenemase gene from an environmental Acinetobacter baumannii isolate. |
| AID531580 | Antibacterial activity against Citrobacter braakii obtained from complicated skin and skin structure infections by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro activity of ceftobiprole against pathogens from two phase 3 clinical trials of complicated skin and skin structure infections. |
| AID498828 | Antimicrobial activity against carbapenem-resistant Enterobacter cloacae SZ92 deficient in IMP-4, TEM-1, CTX-M-14, DHA-1, qnrB10/B4-like, aac(6')-Ib, ompC by CLSI method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Phenotypic and genotypic characterization of Enterobacteriaceae with decreased susceptibility to carbapenems: results from large hospital-based surveillance studies in China. |
| AID554987 | Antibacterial activity against Acinetobacter genomosp. 3 isolate 52 by Etest method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Genetic variability among ampC genes from acinetobacter genomic species 3. |
| AID283538 | Antibacterial activity against Pseudomonas aeruginosa FE53G with inactivated mexZ and nuoG genes by microdilution method | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3 | Cumulative effects of several nonenzymatic mechanisms on the resistance of Pseudomonas aeruginosa to aminoglycosides. |
| AID285589 | Antimicrobial activity against Pseudomonas aeruginosa 65.36-4 tracheal isolates from mechanically ventilated tuberculosis patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID509865 | Antibacterial activity against Acinetobacter baumannii ATCC 17978 isolated from human CSF | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Acinetobacter baumannii increases tolerance to antibiotics in response to monovalent cations. |
| AID574435 | Antimicrobial activity against Escherichia coli isolate 547 expressing beta-lactamase KPC2, TEM and PFGE cluster 4 isolated from blood of patient by vitek-2 method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Carbapenem-resistant KPC-2-producing Escherichia coli in a Tel Aviv Medical Center, 2005 to 2008. |
| AID534388 | Antibacterial activity against Escherichia coli JM109 harboring recombinant pKHM-1 by microdilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | KHM-1, a novel plasmid-mediated metallo-beta-lactamase from a Citrobacter freundii clinical isolate. |
| AID576074 | Antimicrobial activity against ESBL-positive Klebsiella pneumoniae 18260 harboring pSHA2-encoded porin OmpK36 gene by Etest | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | An ertapenem-resistant extended-spectrum-beta-lactamase-producing Klebsiella pneumoniae clone carries a novel OmpK36 porin variant. |
| AID559269 | Antimicrobial activity against Proteus vulgaris Pv5 expressing beta-lactamase PER-1 by Etest | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Emergence of extended-spectrum beta-lactamase PER-1 in Proteus vulgaris and Providencia stuartii isolates from Algiers, Algeria. |
| AID498826 | Antimicrobial activity against Citrobacter freundii SZ63 expressing IMP-4, qnrS1by CLSI method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Phenotypic and genotypic characterization of Enterobacteriaceae with decreased susceptibility to carbapenems: results from large hospital-based surveillance studies in China. |
| AID531591 | Antibacterial activity against Salmonella spp. obtained from complicated skin and skin structure infections by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro activity of ceftobiprole against pathogens from two phase 3 clinical trials of complicated skin and skin structure infections. |
| AID373043 | Antimicrobial activity against imipenem and meropenem-resistant Acinetobacter baumannii isolate CY7 by CLSI agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Molecular epidemiology of clinical isolates of carbapenem-resistant Acinetobacter spp. from Chinese hospitals. |
| AID544927 | Antimicrobial activity against Acinetobacter haemolyticus clinical isolate after 18 to 22 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Establishment of in vitro susceptibility testing methodologies and comparative activities of piperacillin in combination with the penem {beta}-lactamase inhibitor BLI-489. |
| AID530347 | Antimicrobial activity against azide-resistant Escherichia coli J53 harboring pCTX-M carrying blaCTX-M-15 and pQep plasmid carrying qepA2 gene by disk diffusion method | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Plasmid-mediated quinolone resistance pump QepA2 in an Escherichia coli isolate from France. |
| AID495656 | Antimicrobial activity against Escherichia coli TOP10 expressing recombinant beta-lactamase BEL-2 by solid agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | BEL-2, an extended-spectrum beta-lactamase with increased activity toward expanded-spectrum cephalosporins in Pseudomonas aeruginosa. |
| AID528530 | Antimicrobial activity against penicillin-resistant Streptococcus agalactiae B40 by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | First molecular characterization of group B streptococci with reduced penicillin susceptibility. |
| AID565533 | Antibacterial activity against mexB, mexY and mexD expressing Pseudomonas aeruginosa isolate Paebeta-02 harboring T residue at 105 position in PDC- 1 and polymorphic OprD gene by Etest method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Molecular epidemiology and mechanisms of carbapenem resistance in Pseudomonas aeruginosa. |
| AID540943 | Antimicrobial activity against Klebsiella pneumoniae HP205 expressing CMY-36 cephalosporinase by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | CMY-31 and CMY-36 cephalosporinases encoded by ColE1-like plasmids. |
| AID517961 | Antimicrobial activity against Stenotrophomonas maltophilia by broth dilution method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli. |
| AID495838 | Hydrolytic activity of Escherichia coli BL21 DE3 beta-lactamase VIM-19 by microacidimetric method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Novel VIM metallo-beta-lactamase variant from clinical isolates of Enterobacteriaceae from Algeria. |
| AID584566 | Antimicrobial activity against Acinetobacter lwoffii isolate M expressing beta-lactamase OXA-58 isolated from tracheal secretion of patient by vitek 2 system | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | In vivo selection of a missense mutation in adeR and conversion of the novel blaOXA-164 gene into blaOXA-58 in carbapenem-resistant Acinetobacter baumannii isolates from a hospitalized patient. |
| AID556759 | Antimicrobial activity against extended spectrum beta-lactamase CTX-M-2-producing Pseudomonas aeruginosa isolate P6208 by Etest | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Further identification of CTX-M-2 extended-spectrum beta-lactamase in Pseudomonas aeruginosa. |
| AID324361 | Activity of Acinetobacter johnsonii SCO1 | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Identification of the novel narrow-spectrum beta-lactamase SCO-1 in Acinetobacter spp. from Argentina. |
| AID533760 | Antibacterial activity against OXA-30, PSE-1, VIM-2 and PER-1 producing Pseudomonas aeruginosa isolate P19 exhibiting PFGE F pattern by 2-fold agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | Nationwide investigation of extended-spectrum beta-lactamases, metallo-beta-lactamases, and extended-spectrum oxacillinases produced by ceftazidime-resistant Pseudomonas aeruginosa strains in France. |
| AID1373313 | Antimicrobial activity against Escherichia coli expressing beta-lactamase MIR-1 by CLSI broth microdilution method | 2018 | Bioorganic & medicinal chemistry letters, 02-15, Volume: 28, Issue:4 | Optimization of novel monobactams with activity against carbapenem-resistant Enterobacteriaceae - Identification of LYS228. |
| AID535641 | Antimicrobial activity against Group B streptococcus serotype V C1 harboring E63K mutation in PBP 2A and L41S mutation in PBP 1B by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | Genetic heterogeneity in pbp genes among clinically isolated group B Streptococci with reduced penicillin susceptibility. |
| AID576289 | Antimicrobial activity against ESBL-positive Klebsiella pneumoniae 16855 harboring porin OmpK36 and OmpK35 genes by Etest | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | An ertapenem-resistant extended-spectrum-beta-lactamase-producing Klebsiella pneumoniae clone carries a novel OmpK36 porin variant. |
| AID510506 | Antibacterial activity against Acinetobacter calcoaceticus/baumannii complex isolate M3AC9-6 expressing KPC beta lactamase | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Detection of KPC in Acinetobacter spp. in Puerto Rico. |
| AID571892 | Antimicrobial activity against ISAba1 linked with the blaOXA-51-type beta-lactamase harboring Acinetobacter baumannii beta clonal group isolate 10 expressing ompA, adeB, adeM, aacA4, blaSHV-5 by Etest method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Correlation of antimicrobial resistance with beta-lactamases, the OmpA-like porin, and efflux pumps in clinical isolates of Acinetobacter baumannii endemic to New York City. |
| AID625281 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for cholelithiasis | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID1361172 | Antimicrobial activity against OXA-23/OXA-58 producing Acinetobacter baumannii SR27323 in presence of human apo-transferrin by broth microdilution method | 2018 | European journal of medicinal chemistry, Jul-15, Volume: 155 | Cefiderocol (S-649266), A new siderophore cephalosporin exhibiting potent activities against Pseudomonas aeruginosa and other gram-negative pathogens including multi-drug resistant bacteria: Structure activity relationship. |
| AID534926 | Antimicrobial activity against Ceftazidime susceptible Serratia marcescens assessed as resistant isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activity of doripenem, a carbapenem for the treatment of challenging infections caused by gram-negative bacteria, against recent clinical isolates from the United States. |
| AID499152 | fCmax in immunocompromized SKH1 mouse plasma at 50 mg/kg, sc | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vivo activity of ceftobiprole in murine skin infections due to Staphylococcus aureus and Pseudomonas aeruginosa. |
| AID520707 | Antibacterial activity against Acinetobacter baumannii phenotype 2 by disk diffusion method | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Carbapenem-resistant Acinetobacter baumannii isolates from Tunisia producing the OXA-58-like carbapenem-hydrolyzing oxacillinase OXA-97. |
| AID285635 | Antimicrobial activity against Pseudomonas aeruginosa 12A3 tracheal isolates from mechanically ventilated chronic respiratory insufficiency patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID564451 | Antimicrobial activity against Pseudomonas aeruginosa isolate 1036 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | In vivo efficacy of 1- and 2-gram human simulated prolonged infusions of doripenem against Pseudomonas aeruginosa. |
| AID1225774 | Antibacterial activity against Enterobacter cloacae ECL1061 expressing Hyper AmpC /KPC-3 by broth microdilution method | 2015 | Journal of medicinal chemistry, May-14, Volume: 58, Issue:9 | Discovery of a Cyclic Boronic Acid β-Lactamase Inhibitor (RPX7009) with Utility vs Class A Serine Carbapenemases. |
| AID529196 | Antibacterial activity against ESBL-producing Escherichia coli isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Comparison of antimicrobial resistance profiles among extended-spectrum-beta-lactamase-producing and acquired AmpC beta-lactamase-producing Escherichia coli isolates from Canadian intensive care units. |
| AID583642 | Cmin in febrile neutropenic patient with neurological disorder at 2 g administered as 30 mins infusion every 8 hrs measured after 4 days by HPLC analysis | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | High cefepime plasma concentrations and neurological toxicity in febrile neutropenic patients with mild impairment of renal function. |
| AID532029 | Antimicrobial activity against Escherichia coli TOP10F' transformant harboring beta-lactamase CTX-M-78 by disk diffusion method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Novel chromosome-encoded CTX-M-78 beta-lactamase from a Kluyvera georgiana clinical isolate as a putative origin of CTX-M-25 subgroup. |
| AID560057 | Antimicrobial activity against ESBL-producing Escherichia coli by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | In vitro activity of ceftaroline alone and in combination against clinical isolates of resistant gram-negative pathogens, including beta-lactamase-producing Enterobacteriaceae and Pseudomonas aeruginosa. |
| AID528816 | Antimicrobial activity against carbapenem-resistant Enterobacter cloacae isolated from ICU patient wound assessed as resistant isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Antimicrobial-resistant pathogens in intensive care units in Canada: results of the Canadian National Intensive Care Unit (CAN-ICU) study, 2005-2006. |
| AID1139541 | Antibacterial activity against Escherichia coli DH5alpha expressing beta-lactamase TEM-24 by CLSI broth microdilution method | 2014 | Journal of medicinal chemistry, May-08, Volume: 57, Issue:9 | Siderophore receptor-mediated uptake of lactivicin analogues in gram-negative bacteria. |
| AID542062 | Antibacterial activity against Klebsiella pneumoniae D expressing CTX-M group 1 beta-lactamase by Etest method | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Nationwide survey of CTX-M-type extended-spectrum beta-lactamases among Klebsiella pneumoniae isolates in Slovenian hospitals. |
| AID1318925 | Antibacterial activity against pandrug-resistant Pseudomonas aeruginosa isolate 101243 | 2016 | Journal of medicinal chemistry, 09-22, Volume: 59, Issue:18 | Hybrid Antibiotic Overcomes Resistance in P. aeruginosa by Enhancing Outer Membrane Penetration and Reducing Efflux. |
| AID511668 | Antimicrobial activity against beta-lactam resistant Pseudomonas aeruginosa PAOD2 harboring oprD spontaneous mutant and deficient in dacB gene selected in vitro after antipseudomonal treatment of intensive care unit patient by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Activity of a new cephalosporin, CXA-101 (FR264205), against beta-lactam-resistant Pseudomonas aeruginosa mutants selected in vitro and after antipseudomonal treatment of intensive care unit patients. |
| AID564015 | Antibacterial activity against Pseudomonas aeruginosa PAO1 harboring Pseudomonas aeruginosa plasmid DNA lung biopsy specimen of patient by Etest | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Detection of the novel extended-spectrum beta-lactamase OXA-161 from a plasmid-located integron in Pseudomonas aeruginosa clinical isolates from Spain. |
| AID573369 | Antibacterial activity against ceftazidime-susceptible Proteus mirabilis assessed as resistant isolates by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID571694 | Antimicrobial activity against Acinetobacter baumannii alpha clonal group isolate 3 expressing ampC, ompA, adeB, adeM, aacC1, aadA1 by Etest method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Correlation of antimicrobial resistance with beta-lactamases, the OmpA-like porin, and efflux pumps in clinical isolates of Acinetobacter baumannii endemic to New York City. |
| AID528972 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus isolated from ICU patient blood assessed as resistant isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Antimicrobial-resistant pathogens in intensive care units in Canada: results of the Canadian National Intensive Care Unit (CAN-ICU) study, 2005-2006. |
| AID368502 | Activity of Klebsiella pneumoniae TEM26 assessed as drug hydrolysis by spectrophotometry relative to cephaloridine | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID394689 | Antibacterial activity against beta-lactams resistant Pseudomonas aeruginosa isolate expressing PSE-1, MexXY-OprM pump by macrodilution technique | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10 | Pseudomonas aeruginosa may accumulate drug resistance mechanisms without losing its ability to cause bloodstream infections. |
| AID285633 | Antimicrobial activity against Pseudomonas aeruginosa 10B1 tracheal isolates from mechanically ventilated chronic respiratory insufficiency patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID532390 | Antibacterial activity against VIM-1 producing Pseudomonas putida isolate RM-11X-11 by Etest method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | First countrywide survey of acquired metallo-beta-lactamases in gram-negative pathogens in Italy. |
| AID564530 | Antimicrobial activity against Escherichia coli TOP10 harboring pADC-33 plasmid with entire blaAmpC gene by Etest method | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | Extended-spectrum cephalosporinase in Acinetobacter baumannii. |
| AID572132 | Antimicrobial activity against Acinetobacter baumannii nu clonal group isolate 33 expressing ampC, ompA, adeB, adeM by Etest method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Correlation of antimicrobial resistance with beta-lactamases, the OmpA-like porin, and efflux pumps in clinical isolates of Acinetobacter baumannii endemic to New York City. |
| AID576068 | Antimicrobial activity against ESBL-positive Klebsiella pneumoniae 69036 harboring porin OmpK36V mutant gene by Etest | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | An ertapenem-resistant extended-spectrum-beta-lactamase-producing Klebsiella pneumoniae clone carries a novel OmpK36 porin variant. |
| AID516144 | Antibacterial activity against Pulsotype I Acinetobacter genomosp. 3 isolate 10 containing IMP-1, OXA-58, ADC-18, ISAba1, ISAba3, IS1008, intI1 genetic elements by broth micro dilution | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Molecular characterization of beta-lactamase genes and their genetic structures in Acinetobacter genospecies 3 isolates in Taiwan. |
| AID563976 | Activity of Klebsiella pneumoniae 05-560 beta-lactamase VIM2 by spectrophotometry | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Characterization of a new metallo-beta-lactamase gene, bla(NDM-1), and a novel erythromycin esterase gene carried on a unique genetic structure in Klebsiella pneumoniae sequence type 14 from India. |
| AID520779 | Antibacterial activity against Escherichia coli EC600 by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Emergence of Serratia marcescens, Klebsiella pneumoniae, and Escherichia coli Isolates possessing the plasmid-mediated carbapenem-hydrolyzing beta-lactamase KPC-2 in intensive care units of a Chinese hospital. |
| AID540946 | Antimicrobial activity against Escherichia coli DH5[alpha] harboring pB-c31 plasmid expressing cephalosporinase CMY-31 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | CMY-31 and CMY-36 cephalosporinases encoded by ColE1-like plasmids. |
| AID563967 | Antibacterial activity against Escherichia coli TOP10 by Etest method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Characterization of a new metallo-beta-lactamase gene, bla(NDM-1), and a novel erythromycin esterase gene carried on a unique genetic structure in Klebsiella pneumoniae sequence type 14 from India. |
| AID517956 | Antimicrobial activity against Proteus penneri by broth dilution method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli. |
| AID535707 | Antibacterial activity against Escherichia coli TOP10 expressing AmpC-B2 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Role of the Ser-287-Asn replacement in the hydrolysis spectrum extension of AmpC beta-lactamases in Escherichia coli. |
| AID508300 | Inhibition of low-affinity PBP5fm in penicillin-resistant Enterococcus faecium D63r membranes assessed as inhibition of fluorescent ampicillin binding after 20 mins at 37 degC | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2 | Interaction of ceftobiprole with the low-affinity PBP 5 of Enterococcus faecium. |
| AID546160 | Antimicrobial activity against Pseudomonas aeruginosa PAO1 with PDC-1 variant by Etest | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Extended-spectrum cephalosporinases in Pseudomonas aeruginosa. |
| AID547541 | Antimicrobial activity against invasive Streptococcus constellatus obtained from non-cystic fibrosis patient assessed as non-susceptible isolates grown on brain heart infusion agar at 30 ug/ml after 24 hrs at 37 degC by disk diffusion method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Macrolide and clindamycin resistance in Streptococcus milleri group isolates from the airways of cystic fibrosis patients. |
| AID518728 | Activity of Pseudomonas stutzeri beta-lactamase DIM-1 by UV-spectrophotometry | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Characterization of DIM-1, an integron-encoded metallo-beta-lactamase from a Pseudomonas stutzeri clinical isolate in the Netherlands. |
| AID394713 | Antibacterial activity against beta-lactams resistant Pseudomonas aeruginosa isolate expressing AmpC by macrodilution technique | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10 | Pseudomonas aeruginosa may accumulate drug resistance mechanisms without losing its ability to cause bloodstream infections. |
| AID301091 | Antibacterial activity against beta-lactamase negative ampicillin resistant Haemophilus influenzae SR-11435 after 20 hrs by agar dilution method | 2007 | Bioorganic & medicinal chemistry, Nov-01, Volume: 15, Issue:21 | A novel series of parenteral cephalosporins exhibiting potent activities against Pseudomonas aeruginosa and other Gram-negative pathogens: synthesis and structure-activity relationships. |
| AID559905 | Antimicrobial activity against Escherichia coli DH5alpha by Etest method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | First detection of plasmid-encoded blaOXY beta-lactamase. |
| AID283545 | Antibacterial activity against Pseudomonas aeruginosa FE57GUZ with inactivated rplY, nuoG, galU and mexZ genes by microdilution method | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3 | Cumulative effects of several nonenzymatic mechanisms on the resistance of Pseudomonas aeruginosa to aminoglycosides. |
| AID429078 | Antibacterial activity against Escherichia coli J53 expressing Klebsiella pneumoniae Greece blaKPC-2 gene by E test method | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | Plasmid-mediated carbapenem-hydrolyzing beta-lactamase KPC-2 in Klebsiella pneumoniae isolate from Greece. |
| AID285265 | Antimicrobial activity against Escherichia coli DH5-alpha isolate expressing pBK-CMV by disk diffusion assay | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Evolution of TEM-type enzymes: biochemical and genetic characterization of two new complex mutant TEM enzymes, TEM-151 and TEM-152, from a single patient. |
| AID565507 | Antibacterial activity against oprD, mexB, mexY and mexD expressing Pseudomonas aeruginosa isolate Paebeta-25 harboring T residue at 105 position in PDC- 6 by Etest method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Molecular epidemiology and mechanisms of carbapenem resistance in Pseudomonas aeruginosa. |
| AID519011 | Ratio of Kcat to Km for Beta-lactamase TEM-149 T182M mutant expressed in Escherichia coli HB101 | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | E240V substitution increases catalytic efficiency toward ceftazidime in a new natural TEM-type extended-spectrum beta-lactamase, TEM-149, from Enterobacter aerogenes and Serratia marcescens clinical isolates. |
| AID520967 | Antibacterial activity against Escherichia coli harboring pNYC plasmid expressing blaKPC gene by Etest method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Genetic structures at the origin of acquisition of the beta-lactamase bla KPC gene. |
| AID556699 | Antimicrobial activity against multidrug resistant Escherichia coli ATCC 35218 harboring pDrive plasmid by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Occurrence of efflux mechanism and cephalosporinase variant in a population of Enterobacter aerogenes and Klebsiella pneumoniae isolates producing extended-spectrum beta-lactamases. |
| AID285510 | Antibacterial activity against Acinetobacter baumannii after 24 hrs by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | In vitro and in vivo antibacterial activities of heteroaryl isothiazolones against resistant gram-positive pathogens. |
| AID285598 | Antimicrobial activity against Pseudomonas aeruginosa 2C1 tracheal isolates from mechanically ventilated tuberculosis patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID530346 | Antimicrobial activity against azide-resistant Escherichia coli J53 harboring pCTX-M plasmid carrying blaCTX-M-15 gene by disk diffusion method | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Plasmid-mediated quinolone resistance pump QepA2 in an Escherichia coli isolate from France. |
| AID428272 | Antimicrobial activity against carbapenemase producing Enterobacter sp. by CLSI broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | Antimicrobial activities of tigecycline and other broad-spectrum antimicrobials tested against serine carbapenemase- and metallo-beta-lactamase-producing Enterobacteriaceae: report from the SENTRY Antimicrobial Surveillance Program. |
| AID499068 | Antimicrobial activity against carbapenem-resistant Enterobacter cloacae NJ90 deficient in CTX-M-14, ompC/F by CLSI method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Phenotypic and genotypic characterization of Enterobacteriaceae with decreased susceptibility to carbapenems: results from large hospital-based surveillance studies in China. |
| AID584554 | Antimicrobial activity against Acinetobacter lwoffii isolate A expressing beta-lactamase OXA-164 isolated from tracheal secretion of patient by vitek 2 system | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | In vivo selection of a missense mutation in adeR and conversion of the novel blaOXA-164 gene into blaOXA-58 in carbapenem-resistant Acinetobacter baumannii isolates from a hospitalized patient. |
| AID544497 | Ratio of MIC for Escherichia coli TOP10 harboring beta-lactamase KPC-5 to MIC for Escherichia coli TOP10 | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Phenotypic and enzymatic comparative analysis of the novel KPC variant KPC-5 and its evolutionary variants, KPC-2 and KPC-4. |
| AID285648 | Antimicrobial activity against Pseudomonas aeruginosa 19B3 tracheal isolates from mechanically ventilated chronic respiratory insufficiency patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID1225765 | Antibacterial activity against Escherichia coli EC1008 expressing CTX-M-3 by broth microdilution method | 2015 | Journal of medicinal chemistry, May-14, Volume: 58, Issue:9 | Discovery of a Cyclic Boronic Acid β-Lactamase Inhibitor (RPX7009) with Utility vs Class A Serine Carbapenemases. |
| AID571894 | Antimicrobial activity against ISAba1 linked with the blaOXA-51-type beta-lactamase harboring Acinetobacter baumannii beta clonal group isolate 11 expressing ompA, adeB, adeM, blaSHV-5 by Etest method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Correlation of antimicrobial resistance with beta-lactamases, the OmpA-like porin, and efflux pumps in clinical isolates of Acinetobacter baumannii endemic to New York City. |
| AID285267 | Activity of Escherichia coli BL21(DE3) beta-lactamase TEM29 | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Evolution of TEM-type enzymes: biochemical and genetic characterization of two new complex mutant TEM enzymes, TEM-151 and TEM-152, from a single patient. |
| AID1318929 | Antibacterial activity against multidrug-resistant/tobramycin-susceptible Pseudomonas aeruginosa isolate 86079 | 2016 | Journal of medicinal chemistry, 09-22, Volume: 59, Issue:18 | Hybrid Antibiotic Overcomes Resistance in P. aeruginosa by Enhancing Outer Membrane Penetration and Reducing Efflux. |
| AID285339 | Antimicrobial activity against streptomycin-resistant Escherichia coli J53 by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | First report of plasmid-mediated qnrA1 in a ciprofloxacin-resistant Escherichia coli strain in Latin America. |
| AID511391 | Antibacterial activity against Citrobacter freundii by broth dilution method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Comparative in vitro activities of nemonoxacin (TG-873870), a novel nonfluorinated quinolone, and other quinolones against clinical isolates. |
| AID573209 | Antimicrobial activity against mutS::lox-deficient Pseudomonas aeruginosa PAOMSA biofilm harboring nfxB G539A mutant gene selected at 4 ug/ml of azithromycin after 6 passages by Etest method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Azithromycin in Pseudomonas aeruginosa biofilms: bactericidal activity and selection of nfxB mutants. |
| AID761211 | Antibacterial activity against Klebsiella pneumoniae expressing ESBL by broth microdilution method | 2013 | Journal of medicinal chemistry, Jul-11, Volume: 56, Issue:13 | Pyridone-conjugated monobactam antibiotics with gram-negative activity. |
| AID564463 | Antimicrobial activity against Pseudomonas aeruginosa isolate 927 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | In vivo efficacy of 1- and 2-gram human simulated prolonged infusions of doripenem against Pseudomonas aeruginosa. |
| AID531317 | Activity of Escherichia coli beta-lactamase VIM-1 by spectrophotometry | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Kinetic characterization of VIM-7, a divergent member of the VIM metallo-beta-lactamase family. |
| AID534623 | Antimicrobial activity against ESBL producing Escherichia coli by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activity of doripenem, a carbapenem for the treatment of challenging infections caused by gram-negative bacteria, against recent clinical isolates from the United States. |
| AID558802 | Antimicrobial activity against extended spectrum beta-lactamase-deficient Klebsiella oxytoca assessed as percent susceptible isolates by CLSI method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Emergence of high levels of extended-spectrum-beta-lactamase-producing gram-negative bacilli in the Asia-Pacific region: data from the Study for Monitoring Antimicrobial Resistance Trends (SMART) program, 2007. |
| AID522382 | Antimicrobial activity against blaKPC-possessing Klebsiella pneumoniae isolates assessed as susceptible isolates in presence of 4 ug/ml by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | In vitro activity of penem-1 in combination with beta-lactams against blaKPC-possessing Klebsiella pneumoniae isolates. |
| AID508730 | Antibacterial activity against carbapenem-resistant Pseudomonas aeruginosa isolate 3C9 GM1 harboring acquired beta-lactamase OXA-144 by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2 | Activity of a new antipseudomonal cephalosporin, CXA-101 (FR264205), against carbapenem-resistant and multidrug-resistant Pseudomonas aeruginosa clinical strains. |
| AID521993 | Antimicrobial activity against Klebsiella pneumoniae isolate KpB expressing OXA-48 and CTX-M-15 by Etest method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Spread of OXA-48-encoding plasmid in Turkey and beyond. |
| AID528836 | Antimicrobial activity against vancomycin-resistant Enterococcus sp. isolated from ICU patient wound assessed as resistant isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Antimicrobial-resistant pathogens in intensive care units in Canada: results of the Canadian National Intensive Care Unit (CAN-ICU) study, 2005-2006. |
| AID534391 | Antibacterial activity against Escherichia coli JM109 by microdilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | KHM-1, a novel plasmid-mediated metallo-beta-lactamase from a Citrobacter freundii clinical isolate. |
| AID544681 | Antimicrobial activity against AmpC beta-lactamase-producing Enterobacter cloacae clinical isolate after 18 to 22 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Establishment of in vitro susceptibility testing methodologies and comparative activities of piperacillin in combination with the penem {beta}-lactamase inhibitor BLI-489. |
| AID509869 | Antibacterial activity against Acinetobacter baumannii isolate 4860 isolated from human urine | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Acinetobacter baumannii increases tolerance to antibiotics in response to monovalent cations. |
| AID285674 | Antimicrobial activity against Pseudomonas aeruginosa 23C5 tracheal isolates from mechanically ventilated chronic respiratory insufficiency patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID1318918 | Antibacterial activity against multidrug/extremely drug-resistant/colistin-susceptible Pseudomonas aeruginosa isolate 100036 | 2016 | Journal of medicinal chemistry, 09-22, Volume: 59, Issue:18 | Hybrid Antibiotic Overcomes Resistance in P. aeruginosa by Enhancing Outer Membrane Penetration and Reducing Efflux. |
| AID522027 | Antimicrobial activity against Escherichia coli isolate J53 by Etest method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Spread of OXA-48-encoding plasmid in Turkey and beyond. |
| AID283535 | Antibacterial activity against Pseudomonas aeruginosa FE10U with inactivated nuoG and galU genes by microdilution method | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3 | Cumulative effects of several nonenzymatic mechanisms on the resistance of Pseudomonas aeruginosa to aminoglycosides. |
| AID534382 | Antibacterial activity against Escherichia coli K-12 W1895 transconjugant harboring pCF243 by microdilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | KHM-1, a novel plasmid-mediated metallo-beta-lactamase from a Citrobacter freundii clinical isolate. |
| AID559266 | Antimicrobial activity against rifampin-resistant Escherichia coli J53 transconjugated with Proteus vulgaris Pv8 expressing beta-lactamase PER-1 by disk diffusion method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Emergence of extended-spectrum beta-lactamase PER-1 in Proteus vulgaris and Providencia stuartii isolates from Algiers, Algeria. |
| AID342019 | Antibacterial activity against plasmid pK29 transconjugant Escherichia coli J53 by Etest | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8 | Sequencing and comparative genomic analysis of pK29, a 269-kilobase conjugative plasmid encoding CMY-8 and CTX-M-3 beta-lactamases in Klebsiella pneumoniae. |
| AID252617 | Mean lysis diameter of Enterobacter aerogenes EA289 with D113A mutation by standard disk diffusion method on MH agar | 2005 | Journal of medicinal chemistry, Mar-10, Volume: 48, Issue:5 | Beta-lactam screening by specific residues of the OmpF eyelet. |
| AID368497 | Activity of Klebsiella oxytoca beta-lactamase K1assessed as drug hydrolysis by spectrophotometry | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID577648 | Antimicrobial activity against Escherichia coli isolate 157T expressing beta-lactamase KPC2 and PFGE cluster 3 isolated from urine of patient by vitek-2 method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Carbapenem-resistant KPC-2-producing Escherichia coli in a Tel Aviv Medical Center, 2005 to 2008. |
| AID405820 | Antimicrobial activity against Acinetobacter baumannii 501 isolate harboring bla IMP-1 carrying integron In86 containing aminoglycoside resistance gene aac(6')-3 | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | Characterization of an integron carrying blaIMP-1 and a new aminoglycoside resistance gene, aac(6')-31, and its dissemination among genetically unrelated clinical isolates in a Brazilian hospital. |
| AID530602 | Antibacterial activity against Escherichia coli J53 by Etest | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Expanded-spectrum beta-lactamase PER-1 in an environmental Aeromonas media isolate from Switzerland. |
| AID528829 | Antimicrobial activity against ESBL producing Klebsiella pneumoniae assessed as resistant isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Antimicrobial-resistant pathogens in intensive care units in Canada: results of the Canadian National Intensive Care Unit (CAN-ICU) study, 2005-2006. |
| AID529463 | Antimicrobial activity against Klebsiella pneumoniae isolate 21 expressing beta-lactamase Oxa-48, TEM-1 and Oxa-9 by Etest | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Spread of OXA-48-positive carbapenem-resistant Klebsiella pneumoniae isolates in Istanbul, Turkey. |
| AID529655 | Activity of Pseudomonas aeruginosa 9551 beta-lactamase VIM-15 | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | VIM-15 and VIM-16, two new VIM-2-like metallo-beta-lactamases in Pseudomonas aeruginosa isolates from Bulgaria and Germany. |
| AID532402 | Antibacterial activity against VIM-1 producing Pseudomonas aeruginosa clone D4 isolate VA-06X-47 by Etest method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | First countrywide survey of acquired metallo-beta-lactamases in gram-negative pathogens in Italy. |
| AID495803 | Antimicrobial activity against Escherichia coli 2603 strain expressing beta-lactamase VIM-19 by microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Novel VIM metallo-beta-lactamase variant from clinical isolates of Enterobacteriaceae from Algeria. |
| AID565772 | Antimicrobial activity against Pseudomonas aeruginosa OC 12070 expressing 36 fold elevated mexX expression and 39 fold elevated mexY expression by broth macrodilution method | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | Differential selection of single-step AmpC or efflux mutants of Pseudomonas aeruginosa by using cefepime, ceftazidime, or ceftobiprole. |
| AID285667 | Antimicrobial activity against Pseudomonas aeruginosa 22C5 tracheal isolates from mechanically ventilated chronic respiratory insufficiency patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID508479 | Antimicrobial activity against Pseudomonas aeruginosa isolate PA66 producing metallo-beta-lactamase VIM4 by Etest | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Molecular epidemiology of metallo-beta-lactamase-producing Pseudomonas aeruginosa isolates from Norway and Sweden shows import of international clones and local clonal expansion. |
| AID428270 | Antimicrobial activity against Klebsiella sp. assessed as susceptible isolates by CLSI breakpoint assay | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | Antimicrobial activities of tigecycline and other broad-spectrum antimicrobials tested against serine carbapenemase- and metallo-beta-lactamase-producing Enterobacteriaceae: report from the SENTRY Antimicrobial Surveillance Program. |
| AID544956 | Antimicrobial activity against Proteus mirabilis extended-spectrum beta-lactamase producing isolate by Etest | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Characterization and sequence analysis of extended-spectrum-{beta}-lactamase-encoding genes from Escherichia coli, Klebsiella pneumoniae, and Proteus mirabilis isolates collected during tigecycline phase 3 clinical trials. |
| AID405642 | Inhibition of bocillin FL binding to Escherichia coli MC4100 penicillin-binding protein 1a | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | Binding of ceftobiprole and comparators to the penicillin-binding proteins of Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Streptococcus pneumoniae. |
| AID556692 | Antimicrobial activity against multidrug resistant Enterobacter aerogenes ATCC 15038 harboring pACM204 plasmid by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Occurrence of efflux mechanism and cephalosporinase variant in a population of Enterobacter aerogenes and Klebsiella pneumoniae isolates producing extended-spectrum beta-lactamases. |
| AID563969 | Antibacterial activity against Escherichia coli J53 by Etest method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Characterization of a new metallo-beta-lactamase gene, bla(NDM-1), and a novel erythromycin esterase gene carried on a unique genetic structure in Klebsiella pneumoniae sequence type 14 from India. |
| AID583085 | Activity of Escherichia coli BL21(DE3) wild-type VIM-2 beta-lactamase by spectrophotometer | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | Mutational analysis of VIM-2 reveals an essential determinant for metallo-beta-lactamase stability and folding. |
| AID373212 | Activity of Bacillus anthracis beta-lactamase Bla1 | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Molecular and biochemical characterization of the chromosome-encoded class A beta-lactamase BCL-1 from Bacillus clausii. |
| AID556684 | Antimicrobial activity against multidrug resistant Klebsiella pneumoniae isolate 11 by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Occurrence of efflux mechanism and cephalosporinase variant in a population of Enterobacter aerogenes and Klebsiella pneumoniae isolates producing extended-spectrum beta-lactamases. |
| AID322313 | Antibacterial activity against CTX-M group 1 enzyme producing Escherichia coli isolates by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Spread of extended-spectrum beta-lactamase CTX-M-producing escherichia coli clinical isolates in community and nosocomial environments in Portugal. |
| AID565545 | Antibacterial activity against mexB, mexY and mexD expressing Pseudomonas aeruginosa isolate Paebeta-09 harboring A residue at 105 position in PDC- 2 and insertion of ISPa27 sequence in OprD gene by Etest method in presence of cloxacillin | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Molecular epidemiology and mechanisms of carbapenem resistance in Pseudomonas aeruginosa. |
| AID573341 | Antibacterial activity against ceftazidime-susceptible Citrobacter freundii assessed as susceptible isolates by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID531314 | Ratio of Kcat to Km for Pseudomonas aeruginosa beta-lactamase VIM-7 by spectrophotometry | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Kinetic characterization of VIM-7, a divergent member of the VIM metallo-beta-lactamase family. |
| AID495903 | Antimicrobial activity in Escherichia coli DIH-1 expressing beta-lactamase VIM-19 by Etest | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | VIM-19, a metallo-beta-lactamase with increased carbapenemase activity from Escherichia coli and Klebsiella pneumoniae. |
| AID531751 | Antibacterial activity against Pseudomonas aeruginosa 3308 by twofold serial dilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Resistance and virulence of Pseudomonas aeruginosa clinical strains overproducing the MexCD-OprJ efflux pump. |
| AID565540 | Antibacterial activity against oprD, mexB, mexY and mexD expressing Pseudomonas aeruginosa isolate Paebeta-04 harboring A residue at 105 position in PDC- 2 by Etest method in presence of cloxacillin | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Molecular epidemiology and mechanisms of carbapenem resistance in Pseudomonas aeruginosa. |
| AID544894 | Antimicrobial activity against class A extended spectrum beta-lactamase- and class D OXA- producing Klebsiella pneumoniae clinical isolate after 18 to 22 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Establishment of in vitro susceptibility testing methodologies and comparative activities of piperacillin in combination with the penem {beta}-lactamase inhibitor BLI-489. |
| AID1361167 | Antimicrobial activity against IMP-1 producing Pseudomonas aeruginosa SR27001 in presence of human apo-transferrin by broth microdilution method | 2018 | European journal of medicinal chemistry, Jul-15, Volume: 155 | Cefiderocol (S-649266), A new siderophore cephalosporin exhibiting potent activities against Pseudomonas aeruginosa and other gram-negative pathogens including multi-drug resistant bacteria: Structure activity relationship. |
| AID285634 | Antimicrobial activity against Pseudomonas aeruginosa 10B3 tracheal isolates from mechanically ventilated chronic respiratory insufficiency patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID534379 | Antibacterial activity against Citrobacter freundii KHM243 clinical isolate by microdilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | KHM-1, a novel plasmid-mediated metallo-beta-lactamase from a Citrobacter freundii clinical isolate. |
| AID535366 | Antimicrobial activity against Pseudomonas aeruginosa isolated from ICU patient by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activity of doripenem, a carbapenem for the treatment of challenging infections caused by gram-negative bacteria, against recent clinical isolates from the United States. |
| AID285631 | Antimicrobial activity against Pseudomonas aeruginosa 10A6 tracheal isolates from mechanically ventilated chronic respiratory insufficiency patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID517947 | Antimicrobial activity against Enterobacter aerogenes by broth dilution method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli. |
| AID524436 | Antimicrobial activity against Shigella flexneri isolate AM19035 by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Identification and characterization of CTX-M-producing Shigella isolates in the United States. |
| AID565525 | Antibacterial activity against oprD, mexB, mexY and mexD expressing Pseudomonas aeruginosa isolate Paebeta-10 harboring A residue at 105 position in PDC- 2 by Etest method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Molecular epidemiology and mechanisms of carbapenem resistance in Pseudomonas aeruginosa. |
| AID562738 | Antimicrobial activity against Escherichia coli K-12 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | New variant of CTX-M-type extended-spectrum beta-lactamases, CTX-M-71, with a Gly238Cys substitution in a Klebsiella pneumoniae isolate from Bulgaria. |
| AID556680 | Antimicrobial activity against multidrug resistant Klebsiella pneumoniae isolate 7 by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Occurrence of efflux mechanism and cephalosporinase variant in a population of Enterobacter aerogenes and Klebsiella pneumoniae isolates producing extended-spectrum beta-lactamases. |
| AID541805 | Antimicrobial activity against Enterococcus casseliflavus clinical isolate after 18 to 22 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Establishment of in vitro susceptibility testing methodologies and comparative activities of piperacillin in combination with the penem {beta}-lactamase inhibitor BLI-489. |
| AID373048 | Antimicrobial activity against imipenem and meropenem-resistant Acinetobacter baumannii isolate FZ84 by CLSI agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Molecular epidemiology of clinical isolates of carbapenem-resistant Acinetobacter spp. from Chinese hospitals. |
| AID625279 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for bilirubinemia | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID546427 | Activity at Pseudomonas aeruginosa PDC-2 by spectrophotometer | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Extended-spectrum cephalosporinases in Pseudomonas aeruginosa. |
| AID583095 | Antimicrobial activity against Escherichia coli XL1-Blue harboring pLBII-VIM-2 plasmid expressing VIM-2 W87A mutant beta-lactamase by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | Mutational analysis of VIM-2 reveals an essential determinant for metallo-beta-lactamase stability and folding. |
| AID558043 | Antimicrobial activity against blaKPC-positive Klebsiella pneumoniae S6 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Genetic organization of transposase regions surrounding blaKPC carbapenemase genes on plasmids from Klebsiella strains isolated in a New York City hospital. |
| AID541781 | Antimicrobial activity against penicillin-resistant Streptococcus pneumoniae clinical isolate after 18 to 22 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Establishment of in vitro susceptibility testing methodologies and comparative activities of piperacillin in combination with the penem {beta}-lactamase inhibitor BLI-489. |
| AID559261 | Antimicrobial activity against Proteus vulgaris Pv8 expressing beta-lactamase PER-1 by disk diffusion method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Emergence of extended-spectrum beta-lactamase PER-1 in Proteus vulgaris and Providencia stuartii isolates from Algiers, Algeria. |
| AID425653 | Renal clearance in human | 2009 | Journal of medicinal chemistry, Aug-13, Volume: 52, Issue:15 | Physicochemical determinants of human renal clearance. |
| AID518823 | Antibacterial activity against Pulsotype C Acinetobacter genomosp. 3 isolate 1 containing IMP-1, OXA-58, ADC-18, ISAba1, ISAba3, IS1008, intI1 genetic elements by broth micro dilution | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Molecular characterization of beta-lactamase genes and their genetic structures in Acinetobacter genospecies 3 isolates in Taiwan. |
| AID564536 | Antimicrobial activity against Escherichia coli TOP10 harboring pTOPO plasmid by Etest method | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | Extended-spectrum cephalosporinase in Acinetobacter baumannii. |
| AID508295 | Inhibition of PBP1 in penicillin-resistant Enterococcus faecium D63r membranes assessed as inhibition of fluorescent ampicillin binding after 20 mins at 37 degC | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2 | Interaction of ceftobiprole with the low-affinity PBP 5 of Enterococcus faecium. |
| AID565538 | Antibacterial activity against mexB, mexY and mexD expressing Pseudomonas aeruginosa isolate Paebeta-02 harboring T residue at 105 position in PDC- 1, and polymorphic OprD gene by Etest method in presence of cloxacillin | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Molecular epidemiology and mechanisms of carbapenem resistance in Pseudomonas aeruginosa. |
| AID368542 | Ratio of Kcat to Km of Pseudomonas aeruginosa 4352 AmpC assessed as drug hydrolysis by spectrophotometry relative to cephaloridine | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID531745 | Antibacterial activity against Pseudomonas aeruginosa PAO1 by twofold serial dilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Resistance and virulence of Pseudomonas aeruginosa clinical strains overproducing the MexCD-OprJ efflux pump. |
| AID562767 | Antimicrobial activity against Escherichia coli DH10B transformant harboring blaTEM-168 gene by broth microdilution method in presence of clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | TEM-168, a heretofore laboratory-derived TEM beta-lactamase variant found in an Escherichia coli clinical isolate. |
| AID1373310 | Antimicrobial activity against Escherichia coli expressing beta-lactamase AmpC by CLSI broth microdilution method | 2018 | Bioorganic & medicinal chemistry letters, 02-15, Volume: 28, Issue:4 | Optimization of novel monobactams with activity against carbapenem-resistant Enterobacteriaceae - Identification of LYS228. |
| AID565727 | Antibacterial activity against oprD, mexB, mexY and mexD expressing Pseudomonas aeruginosa isolate Paebeta-32 harboring A residue at 105 position in PDC- 10 by Etest method in presence of cloxacillin | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Molecular epidemiology and mechanisms of carbapenem resistance in Pseudomonas aeruginosa. |
| AID583646 | Neurotoxicity in febrile neutropenic patient assessed as hallucinations at 2 g administered as 30 mins infusion every 8 hrs | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | High cefepime plasma concentrations and neurological toxicity in febrile neutropenic patients with mild impairment of renal function. |
| AID529456 | Antimicrobial activity against Klebsiella pneumoniae containing PFGE clone A expressing beta-lactamase Oxa-48, TEM-1, SHV-12 and Oxa-9 by Etest | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Spread of OXA-48-positive carbapenem-resistant Klebsiella pneumoniae isolates in Istanbul, Turkey. |
| AID373207 | Antimicrobial activity against Bacillus clausii ATCC 21536 by agar-dilution technique | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Molecular and biochemical characterization of the chromosome-encoded class A beta-lactamase BCL-1 from Bacillus clausii. |
| AID533765 | Antibacterial activity against OXA-19 producing Pseudomonas aeruginosa isolate P9 exhibiting PFGE A pattern by 2-fold agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | Nationwide investigation of extended-spectrum beta-lactamases, metallo-beta-lactamases, and extended-spectrum oxacillinases produced by ceftazidime-resistant Pseudomonas aeruginosa strains in France. |
| AID518464 | Antimicrobial activity against Pseudomonas aeruginosa BA assessed as number of passages required for MIC to rise above 4 times original MIC | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli. |
| AID540214 | Clearance in rat after iv administration | 2005 | Journal of pharmaceutical sciences, Jul, Volume: 94, Issue:7 | Extrapolation of human pharmacokinetic parameters from rat, dog, and monkey data: Molecular properties associated with extrapolative success or failure. |
| AID535645 | Antimicrobial activity against Group B Streptococcus serotype Ia N1 harboring E63K mutation in PBP 2A and L41S mutation in PBP 1B by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | Genetic heterogeneity in pbp genes among clinically isolated group B Streptococci with reduced penicillin susceptibility. |
| AID535716 | Activity of Escherichia coli TOP10 beta-lactamase AmpC-B2 | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Role of the Ser-287-Asn replacement in the hydrolysis spectrum extension of AmpC beta-lactamases in Escherichia coli. |
| AID560125 | Antimicrobial activity against Acinetobacter baumannii CIP70.10 harboring beta-lactamase RTG3 gene by disk diffusion method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Genetic and biochemical characterization of the first extended-spectrum CARB-type beta-lactamase, RTG-4, from Acinetobacter baumannii. |
| AID524747 | Antimicrobial activity against Escherichia coli GB20 harboring V27A, Q38R, A77V, N114D, A140S, D288N mutations in beta lactamase CTX-M-1 by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Mutational events in cefotaximase extended-spectrum beta-lactamases of the CTX-M-1 cluster involved in ceftazidime resistance. |
| AID535861 | Antimicrobial activity against aac(6')-Ib-cr-negative Enterobacter cloacae GZ47 harboring qnrB and qnrS genes by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | High prevalence of plasmid-mediated quinolone resistance genes qnr and aac(6')-Ib-cr in clinical isolates of Enterobacteriaceae from nine teaching hospitals in China. |
| AID532199 | Antimicrobial activity against aac(6')-Ib-cr-negative Enterobacter cloacae WH42T harboring qnrA gene by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | High prevalence of plasmid-mediated quinolone resistance genes qnr and aac(6')-Ib-cr in clinical isolates of Enterobacteriaceae from nine teaching hospitals in China. |
| AID517958 | Antimicrobial activity against Serratia marcescens by broth dilution method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli. |
| AID561676 | Antimicrobial activity against Pseudomonas aeruginosa isolate OC17355 harboring plasmid MexZ expressing mexXY gene by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Effect of MexXY overexpression on ceftobiprole susceptibility in Pseudomonas aeruginosa. |
| AID495513 | Antibacterial activity against Acinetobacter baumannii BM4467 by antimicrobial susceptibility assay | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Screening and quantification of the expression of antibiotic resistance genes in Acinetobacter baumannii with a microarray. |
| AID511584 | Antimicrobial activity against beta-lactam resistant Pseudomonas aeruginosa PAOD3 harboring oprD spontaneous mutant selected in vitro after antipseudomonal treatment of intensive care unit patient by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Activity of a new cephalosporin, CXA-101 (FR264205), against beta-lactam-resistant Pseudomonas aeruginosa mutants selected in vitro and after antipseudomonal treatment of intensive care unit patients. |
| AID558796 | Antimicrobial activity against extended spectrum beta-lactamase-deficient Escherichia coli assessed as percent susceptible isolates by CLSI method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Emergence of high levels of extended-spectrum-beta-lactamase-producing gram-negative bacilli in the Asia-Pacific region: data from the Study for Monitoring Antimicrobial Resistance Trends (SMART) program, 2007. |
| AID561667 | Antimicrobial activity against Pseudomonas aeruginosa PAO1 harboring plasmid MexZ expressing mexXY gene by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Effect of MexXY overexpression on ceftobiprole susceptibility in Pseudomonas aeruginosa. |
| AID534866 | Antimicrobial activity against Non-ESBL Proteus mirabilis assessed as resistant isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activity of doripenem, a carbapenem for the treatment of challenging infections caused by gram-negative bacteria, against recent clinical isolates from the United States. |
| AID561447 | Antibacterial activity against Escherichia coli DH10B harboring plasmid BCSK by Etest method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Reduced susceptibility to cefepime among Escherichia coli clinical isolates producing novel variants of CMY-2 beta-lactamase. |
| AID560090 | Bactericidal activity against Enterobacter cloacae isolate 5420 at 1/4 times MIC after 24 hrs by time kill analysis | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | In vitro activity of ceftaroline alone and in combination against clinical isolates of resistant gram-negative pathogens, including beta-lactamase-producing Enterobacteriaceae and Pseudomonas aeruginosa. |
| AID549330 | Antimicrobial activity against Escherichia coli isolate 16 harboring bla CTX-M-3a gene by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | blaCTX-M genes in escherichia coli strains from Croatian Hospitals are located in new (blaCTX-M-3a) and widely spread (blaCTX-M-3a and blaCTX-M-15) genetic structures. |
| AID525506 | Ratio of fCmin in Pseudomonas aeruginosa infected patient to MIC against Pseudomonas aeruginosa | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Clinical pharmacodynamics of cefepime in patients infected with Pseudomonas aeruginosa. |
| AID495841 | Ratio of Kcat to Km for beta-lactamase VIM-1 in Escherichia coli DH5alpha expressing pBCLL/39H by microacidimetric method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Novel VIM metallo-beta-lactamase variant from clinical isolates of Enterobacteriaceae from Algeria. |
| AID510513 | Antibacterial activity against Escherichia coli ATCC 25922 expressing KPC beta lactamase | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Detection of KPC in Acinetobacter spp. in Puerto Rico. |
| AID555196 | Antimicrobial activity against nagZ gene-deficient Pseudomonas aeruginosa PAO1 after 18 hrs by Etest | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Inactivation of the glycoside hydrolase NagZ attenuates antipseudomonal beta-lactam resistance in Pseudomonas aeruginosa. |
| AID498834 | Antimicrobial activity against carbapenem-resistant Klebsiella pneumoniae PU3 deficient in DHA-1, aac(6')-Ib-cr, ompK35/36 by CLSI method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Phenotypic and genotypic characterization of Enterobacteriaceae with decreased susceptibility to carbapenems: results from large hospital-based surveillance studies in China. |
| AID519980 | Ratio of Kcat to Km for Klebsiella pneumoniae Beta-Lactamase SHV-55 | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Biochemical characterization of SHV-55, an extended-spectrum class A beta-lactamase from Klebsiella pneumoniae. |
| AID567582 | Antimicrobial activity against Acinetobacter baumannii assessed as susceptible isolate by broth dilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | In vitro antimicrobial activity and mutant prevention concentration of colistin against Acinetobacter baumannii. |
| AID368477 | Antibacterial activity against Enterobacter cloacae 4092 producing beta lactamase AmpC (E2) by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID544936 | Antimicrobial activity against Acinetobacter lwoffii clinical isolate after 18 to 22 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Establishment of in vitro susceptibility testing methodologies and comparative activities of piperacillin in combination with the penem {beta}-lactamase inhibitor BLI-489. |
| AID534928 | Antimicrobial activity against Ceftazidime non-susceptible Serratia marcescens assessed as intermediate isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activity of doripenem, a carbapenem for the treatment of challenging infections caused by gram-negative bacteria, against recent clinical isolates from the United States. |
| AID561386 | Antibacterial activity against Escherichia coli isolate ARL04-413 harboring beta-lactamase CMY 2 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | CMY-29 and CMY-30, two novel plasmid-mediated AmpC beta-lactamases. |
| AID516141 | Antibacterial activity against Pulsotype K Acinetobacter genomosp. 3 isolate 6 containing IMP-1, OXA-58, ADC-18, ISAba1, ISAba3, IS1008, intI1 genetic elements by broth micro dilution | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Molecular characterization of beta-lactamase genes and their genetic structures in Acinetobacter genospecies 3 isolates in Taiwan. |
| AID583651 | Antibacterial activity against Escherichia coli isolate 271 | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Emergence of metallo-β-lactamase NDM-1-producing multidrug-resistant Escherichia coli in Australia. |
| AID511585 | Antimicrobial activity against beta-lactam resistant Pseudomonas aeruginosa PAOD1 harboring oprD spontaneous mutant and deficient in ampD gene selected in vitro after antipseudomonal treatment of intensive care unit patient by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Activity of a new cephalosporin, CXA-101 (FR264205), against beta-lactam-resistant Pseudomonas aeruginosa mutants selected in vitro and after antipseudomonal treatment of intensive care unit patients. |
| AID521351 | Antimicrobial activity against Streptococcus pneumoniae isolate k-585 obtained from bronchoalveolar lavage fluid of patient | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Highly variable penicillin resistance determinants PBP 2x, PBP 2b, and PBP 1a in isolates of two Streptococcus pneumoniae clonal groups, Poland 23F-16 and Poland 6B-20. |
| AID529898 | Antimicrobial activity against Leptospira weilii isolate 6 by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Antimicrobial susceptibilities of geographically diverse clinical human isolates of Leptospira. |
| AID285624 | Antimicrobial activity against Pseudomonas aeruginosa 8B11 tracheal isolates from mechanically ventilated chronic respiratory insufficiency patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID556670 | Antimicrobial activity against multidrug resistant Enterobacter aerogenes isolate 25 by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Occurrence of efflux mechanism and cephalosporinase variant in a population of Enterobacter aerogenes and Klebsiella pneumoniae isolates producing extended-spectrum beta-lactamases. |
| AID560133 | Ratio of Kcat to Km for recombinant beta-lactamase RTG4 expressed in Escherichia coli TOP10 by nitrocefin hydrolysis assay | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Genetic and biochemical characterization of the first extended-spectrum CARB-type beta-lactamase, RTG-4, from Acinetobacter baumannii. |
| AID530321 | Antimicrobial activity against Pseudomonas aeruginosa isolate PA-SD2 harboring blaVIM-1 gene by Etest method | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Characterization of the new metallo-beta-lactamase VIM-13 and its integron-borne gene from a Pseudomonas aeruginosa clinical isolate in Spain. |
| AID508481 | Antimicrobial activity against Pseudomonas aeruginosa isolate B4-25753 producing metallo-beta-lactamase VIM2 by Etest | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Molecular epidemiology of metallo-beta-lactamase-producing Pseudomonas aeruginosa isolates from Norway and Sweden shows import of international clones and local clonal expansion. |
| AID531588 | Antibacterial activity against Proteus penneri obtained from complicated skin and skin structure infections by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro activity of ceftobiprole against pathogens from two phase 3 clinical trials of complicated skin and skin structure infections. |
| AID1225770 | Antibacterial activity against Escherichia coli EC1009 expressing TEM-10 by broth microdilution method | 2015 | Journal of medicinal chemistry, May-14, Volume: 58, Issue:9 | Discovery of a Cyclic Boronic Acid β-Lactamase Inhibitor (RPX7009) with Utility vs Class A Serine Carbapenemases. |
| AID368479 | Antibacterial activity against Enterobacter cloacae 4080 producing beta lactamase AmpC (P99) by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID649219 | Antibacterial activity against Pseudomonas aeruginosa clinical isolates after 16 to 20 hrs by broth microdilution method | 2012 | Journal of medicinal chemistry, Jan-26, Volume: 55, Issue:2 | Potent inhibitors of LpxC for the treatment of Gram-negative infections. |
| AID561665 | Antimicrobial activity against Pseudomonas aeruginosa PAO1 harboring plasmid JAK16 expressing mexXY gene by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Effect of MexXY overexpression on ceftobiprole susceptibility in Pseudomonas aeruginosa. |
| AID285676 | Antimicrobial activity against Pseudomonas aeruginosa 24G1 tracheal isolates from mechanically ventilated chronic respiratory insufficiency patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID573346 | Antibacterial activity against ceftazidime-susceptible Enterobacter cloacae by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID368727 | Ratio of Kcat to Km of Serratia marcescens AmpC assessed as drug hydrolysis by spectrophotometry | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID528980 | Antimicrobial activity against Haemophilus influenzae assessed as resistant isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Antimicrobial-resistant pathogens in intensive care units in Canada: results of the Canadian National Intensive Care Unit (CAN-ICU) study, 2005-2006. |
| AID535172 | Antimicrobial activity against imipenem non-susceptible Acinetobacter assessed as intermediate isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activity of doripenem, a carbapenem for the treatment of challenging infections caused by gram-negative bacteria, against recent clinical isolates from the United States. |
| AID498805 | Antimicrobial activity against Klebsiella pneumoniae ZJ70T expressing KPC-2 by CLSI method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Phenotypic and genotypic characterization of Enterobacteriaceae with decreased susceptibility to carbapenems: results from large hospital-based surveillance studies in China. |
| AID573352 | Antibacterial activity against ceftazidime-susceptible Escherichia coli by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID521355 | Antimicrobial activity against Streptococcus pneumoniae isolate 657 obtained from sputum of patient | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Highly variable penicillin resistance determinants PBP 2x, PBP 2b, and PBP 1a in isolates of two Streptococcus pneumoniae clonal groups, Poland 23F-16 and Poland 6B-20. |
| AID535369 | Antimicrobial activity against Pseudomonas aeruginosa isolated from non-ICU patient assessed as susceptible isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activity of doripenem, a carbapenem for the treatment of challenging infections caused by gram-negative bacteria, against recent clinical isolates from the United States. |
| AID285608 | Antimicrobial activity against Pseudomonas aeruginosa 3B1 tracheal isolates from mechanically ventilated tuberculosis patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID761215 | Antibacterial activity against Klebsiella pneumoniae 1487-07 by broth microdilution method | 2013 | Journal of medicinal chemistry, Jul-11, Volume: 56, Issue:13 | Pyridone-conjugated monobactam antibiotics with gram-negative activity. |
| AID588214 | FDA HLAED, liver enzyme composite activity | 2004 | Current drug discovery technologies, Dec, Volume: 1, Issue:4 | Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. |
| AID285263 | Antimicrobial activity against Escherichia coli DH5-alpha TC1295 isolate expressing TEM-1 by disk diffusion assay | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Evolution of TEM-type enzymes: biochemical and genetic characterization of two new complex mutant TEM enzymes, TEM-151 and TEM-152, from a single patient. |
| AID373762 | Antibacterial activity against imipenem-resistant Acinetobacter baumannii ab1266 by broth dilution method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | An OXA-66/OXA-51-like carbapenemase and possibly an efflux pump are associated with resistance to imipenem in Acinetobacter baumannii. |
| AID368319 | Antibacterial activity against Staphylococcus aureus 4116 producing betalactamase PC1 by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID285337 | Antimicrobial activity against Escherichia coli qnrA1 producing urinary specimen isolate 13.52 by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | First report of plasmid-mediated qnrA1 in a ciprofloxacin-resistant Escherichia coli strain in Latin America. |
| AID544673 | Antimicrobial activity against Enterobacter cloacae clinical isolate after 18 to 22 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Establishment of in vitro susceptibility testing methodologies and comparative activities of piperacillin in combination with the penem {beta}-lactamase inhibitor BLI-489. |
| AID511388 | Antibacterial activity against Klebsiella pneumoniae by broth dilution method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Comparative in vitro activities of nemonoxacin (TG-873870), a novel nonfluorinated quinolone, and other quinolones against clinical isolates. |
| AID544958 | Antimicrobial activity against Escherichia coli expressing beta-lactamase CTX by Etest based on single determinant | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Characterization and sequence analysis of extended-spectrum-{beta}-lactamase-encoding genes from Escherichia coli, Klebsiella pneumoniae, and Proteus mirabilis isolates collected during tigecycline phase 3 clinical trials. |
| AID546422 | Antimicrobial activity against Pseudomonas aeruginosa 12B harboring recombinant pBB-PDC-2 by Etest | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Extended-spectrum cephalosporinases in Pseudomonas aeruginosa. |
| AID531754 | Antibacterial activity against Pseudomonas aeruginosa 2439 harboring pNF225 carrying nfxB by twofold serial dilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Resistance and virulence of Pseudomonas aeruginosa clinical strains overproducing the MexCD-OprJ efflux pump. |
| AID285642 | Antimicrobial activity against Pseudomonas aeruginosa 15G2 tracheal isolates from mechanically ventilated chronic respiratory insufficiency patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID495908 | Antimicrobial activity in Escherichia coli TOP10 harbouring recombinant plasmid VIM-1-N215K by Etest | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | VIM-19, a metallo-beta-lactamase with increased carbapenemase activity from Escherichia coli and Klebsiella pneumoniae. |
| AID522758 | Antimicrobial activity against AmpC producing Escherichia coli Top10 isolate 7014517 | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Occurrence of ST23 complex phylogroup A Escherichia coli isolates producing extended-spectrum AmpC beta-lactamase in a French hospital. |
| AID556656 | Antimicrobial activity against multidrug resistant Enterobacter aerogenes isolate 11 by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Occurrence of efflux mechanism and cephalosporinase variant in a population of Enterobacter aerogenes and Klebsiella pneumoniae isolates producing extended-spectrum beta-lactamases. |
| AID544897 | Antimicrobial activity against AmpC- producing Klebsiella pneumoniae clinical isolate after 18 to 22 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Establishment of in vitro susceptibility testing methodologies and comparative activities of piperacillin in combination with the penem {beta}-lactamase inhibitor BLI-489. |
| AID556663 | Antimicrobial activity against multidrug resistant Enterobacter aerogenes isolate 18 by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Occurrence of efflux mechanism and cephalosporinase variant in a population of Enterobacter aerogenes and Klebsiella pneumoniae isolates producing extended-spectrum beta-lactamases. |
| AID529894 | Antimicrobial activity against Leptospira interrogans serovar Grippotyphosa isolate 2 by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Antimicrobial susceptibilities of geographically diverse clinical human isolates of Leptospira. |
| AID533876 | Antibacterial activity against amoxicillin-intermediate Streptococcus pneumoniae isolate by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | In vitro activity of ceftaroline against Streptococcus pneumoniae isolates exhibiting resistance to penicillin, amoxicillin, and cefotaxime. |
| AID576286 | Antimicrobial activity against ESBL-positive Klebsiella pneumoniae 17049 harboring porin OmpK36V mutant gene by Etest | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | An ertapenem-resistant extended-spectrum-beta-lactamase-producing Klebsiella pneumoniae clone carries a novel OmpK36 porin variant. |
| AID1361171 | Antimicrobial activity against L-1 producing Stenotrophomonas maltophilia SR21970 in presence of human apo-transferrin by broth microdilution method | 2018 | European journal of medicinal chemistry, Jul-15, Volume: 155 | Cefiderocol (S-649266), A new siderophore cephalosporin exhibiting potent activities against Pseudomonas aeruginosa and other gram-negative pathogens including multi-drug resistant bacteria: Structure activity relationship. |
| AID545434 | Antimicrobial activity against extended-spectrum beta-lactamase-positive Escherichia coli obtained from patient with complicated intra-abdominal infection assessed as percent susceptible isolates by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Susceptibility of gram-negative pathogens isolated from patients with complicated intra-abdominal infections in the United States, 2007-2008: results of the Study for Monitoring Antimicrobial Resistance Trends (SMART). |
| AID576305 | Antimicrobial activity against ESBL-positive Klebsiella pneumoniae 287942 harboring porin OmpK36 gene by Etest | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | An ertapenem-resistant extended-spectrum-beta-lactamase-producing Klebsiella pneumoniae clone carries a novel OmpK36 porin variant. |
| AID546178 | Antimicrobial activity against AmpC overproducing Pseudomonas aeruginosa isolate Pae-beta-18 with PDC-3 variant by Etest | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Extended-spectrum cephalosporinases in Pseudomonas aeruginosa. |
| AID1373294 | Antimicrobial activity against Escherichia coli expressing beta-lactamase SME-1 by CLSI broth microdilution method | 2018 | Bioorganic & medicinal chemistry letters, 02-15, Volume: 28, Issue:4 | Optimization of novel monobactams with activity against carbapenem-resistant Enterobacteriaceae - Identification of LYS228. |
| AID368320 | Antibacterial activity against Escherichia coli producing beta lactamase TEM1 by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID554392 | Antimicrobial activity against Pseudomonas aeruginosa isolate 3020S obtained from cystic fibrosis patient by disk diffusion method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Efflux unbalance in Pseudomonas aeruginosa isolates from cystic fibrosis patients. |
| AID584096 | Antibacterial activity against colistin-resistant Acinetobacter baumannii ATCC 19606R harboring empty plasmid pWH1266 by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | Colistin resistance in Acinetobacter baumannii is mediated by complete loss of lipopolysaccharide production. |
| AID368520 | Activity of Enterobacter cloacae 4092 AmpC (E2) assessed as drug hydrolysis by spectrophotometry relative to cephaloridine | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID544924 | Antimicrobial activity against Acinetobacter baumannii clinical isolate after 18 to 22 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Establishment of in vitro susceptibility testing methodologies and comparative activities of piperacillin in combination with the penem {beta}-lactamase inhibitor BLI-489. |
| AID533875 | Antibacterial activity against penicillin-nonsusceptible Streptococcus pneumoniae assessed as percent susceptible isolates by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | In vitro activity of ceftaroline against Streptococcus pneumoniae isolates exhibiting resistance to penicillin, amoxicillin, and cefotaxime. |
| AID295839 | Antimicrobial activity against Enterococcus faecalis ATCC 29122 by disk diffusion method at 300 ug/disc | 2007 | European journal of medicinal chemistry, Jul, Volume: 42, Issue:7 | Synthesis of some novel heterocyclic compounds derived from diflunisal hydrazide as potential anti-infective and anti-inflammatory agents. |
| AID322318 | Antibacterial activity against CTX-M group 9 enzyme producing Escherichia coli isolates assessed as percent nonsusceptible isolates by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Spread of extended-spectrum beta-lactamase CTX-M-producing escherichia coli clinical isolates in community and nosocomial environments in Portugal. |
| AID424857 | Antimicrobial activity against Pseudomonas aeruginosa PAO1 harboring pV2GY3 with blaVIM-2 and aac(6)'-32 by E-test | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Molecular epidemiology and mechanisms of carbapenem resistance in Pseudomonas aeruginosa isolates from Spanish hospitals. |
| AID565199 | Antimicrobial activity against Klebsiella pneumoniae isolate T-1780 expressing VIM-1 and KPC-2 genes by microdilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Emerging Klebsiella pneumoniae isolates coproducing KPC-2 and VIM-1 carbapenemases. |
| AID588218 | FDA HLAED, lactate dehydrogenase (LDH) increase | 2004 | Current drug discovery technologies, Dec, Volume: 1, Issue:4 | Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. |
| AID555218 | Antibacterial activity against Escherichia coli DH5alpha carrying ampC gene of Acinetobacter genomosp. 3 isolate 65 by Etest method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Genetic variability among ampC genes from acinetobacter genomic species 3. |
| AID556647 | Antimicrobial activity against multidrug resistant Enterobacter aerogenes isolate 2 by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Occurrence of efflux mechanism and cephalosporinase variant in a population of Enterobacter aerogenes and Klebsiella pneumoniae isolates producing extended-spectrum beta-lactamases. |
| AID520798 | Antimicrobial activity against CTX-M-2 producing Klebsiella pneumoniae with PFGE pulsotype F by Etest | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Multiclonal outbreak of Klebsiella pneumoniae producing extended-spectrum beta-lactamase CTX-M-2 and novel variant CTX-M-59 in a neonatal intensive care unit in Brazil. |
| AID531592 | Antibacterial activity against Serratia marcescens obtained from complicated skin and skin structure infections by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro activity of ceftobiprole against pathogens from two phase 3 clinical trials of complicated skin and skin structure infections. |
| AID520881 | Antibacterial activity against Escherichia coli TOP10 harboring recombinant p6S3 expressing beta lactamase OXA-114a by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Characterization of a naturally occurring class D beta-lactamase from Achromobacter xylosoxidans. |
| AID373768 | Antibacterial activity against imipenem-resistant Acinetobacter baumannii abh18 by broth dilution method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | An OXA-66/OXA-51-like carbapenemase and possibly an efflux pump are associated with resistance to imipenem in Acinetobacter baumannii. |
| AID532411 | Antibacterial activity against VIM-2 producing Pseudomonas aeruginosa clone B3 isolate PV-05X-02 by Etest method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | First countrywide survey of acquired metallo-beta-lactamases in gram-negative pathogens in Italy. |
| AID522005 | Antimicrobial activity against Klebsiella pneumoniae isolate KpI-1 expressing beta-lactamase OXA-48 and CTX-M-15 by Etest method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Spread of OXA-48-encoding plasmid in Turkey and beyond. |
| AID301082 | Antibacterial activity against Enterobacter cloacae ATCC 13047 after 20 hrs by agar dilution method | 2007 | Bioorganic & medicinal chemistry, Nov-01, Volume: 15, Issue:21 | A novel series of parenteral cephalosporins exhibiting potent activities against Pseudomonas aeruginosa and other Gram-negative pathogens: synthesis and structure-activity relationships. |
| AID424854 | Antibacterial activity in Klebsiella sp. infected patient assessed as mortality after 28 days | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Failure of current cefepime breakpoints to predict clinical outcomes of bacteremia caused by gram-negative organisms. |
| AID541522 | Antimicrobial activity against methicillin-resistant Staphylococcus epidermidis clinical isolate after 18 to 22 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Establishment of in vitro susceptibility testing methodologies and comparative activities of piperacillin in combination with the penem {beta}-lactamase inhibitor BLI-489. |
| AID571912 | Antimicrobial activity against ISAba1 linked with the blaOXA-51-type beta-lactamase harboring Acinetobacter baumannii zeta clonal group isolate 20 expressing ampC, ompA, adeB, adeM, aacC2 by Etest method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Correlation of antimicrobial resistance with beta-lactamases, the OmpA-like porin, and efflux pumps in clinical isolates of Acinetobacter baumannii endemic to New York City. |
| AID573370 | Antibacterial activity against ceftazidime-susceptible Serratia marcescens by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID518522 | Antimicrobial activity against Capnocytophaga sputigena CIP 104301T after 2 days by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Characterization of CSP-1, a novel extended-spectrum beta-lactamase produced by a clinical isolate of Capnocytophaga sputigena. |
| AID521994 | Antimicrobial activity against Escherichia coli isolate J53 harboring pBb containing beta-lactamase OXA-48 located within transposon Tn1999.2 by Etest method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Spread of OXA-48-encoding plasmid in Turkey and beyond. |
| AID325197 | Antibacterial activity against beta-lactamase negative ampicillin-resistant Haemophilus influenzae SR-11435 by standard serial agar dilution method | 2008 | Bioorganic & medicinal chemistry, Feb-15, Volume: 16, Issue:4 | A novel series of parenteral cephalosporins exhibiting potent activities against both Pseudomonas aeruginosa and other gram-negative pathogens. Part 2: Synthesis and structure-activity relationships. |
| AID495839 | Ratio of Kcat to Km for Escherichia coli BL21 DE3 beta-lactamase VIM-19 by microacidimetric method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Novel VIM metallo-beta-lactamase variant from clinical isolates of Enterobacteriaceae from Algeria. |
| AID565197 | Antimicrobial activity against Klebsiella pneumoniae isolate H-1406 expressing VIM-1 and KPC-2 genes by microdilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Emerging Klebsiella pneumoniae isolates coproducing KPC-2 and VIM-1 carbapenemases. |
| AID279941 | Antibiotic susceptibility by resistance against non-MDR Pseudomonas aeruginosa from samples collected from patients | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2 | Clinical prediction tool to identify patients with Pseudomonas aeruginosa respiratory tract infections at greatest risk for multidrug resistance. |
| AID283548 | Antibacterial activity against Pseudomonas aeruginosa FE63 containing inactivated rplY and PA5471 genes by microdilution method | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3 | Cumulative effects of several nonenzymatic mechanisms on the resistance of Pseudomonas aeruginosa to aminoglycosides. |
| AID560117 | Antibacterial activity against Escherichia coli TOP10 by Etest method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Genetic and biochemical characterization of the first extended-spectrum CARB-type beta-lactamase, RTG-4, from Acinetobacter baumannii. |
| AID495792 | Antimicrobial activity against Escherichia coli DH10B harbouring recombinant plasmid pSau1 expressing beta-lactamase BIC-1 from Pseudomonas fluorescens PF-1 by Etest | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Novel ambler class A carbapenem-hydrolyzing beta-lactamase from a Pseudomonas fluorescens isolate from the Seine River, Paris, France. |
| AID544915 | Antimicrobial activity against Providencia rettgeri clinical isolate after 18 to 22 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Establishment of in vitro susceptibility testing methodologies and comparative activities of piperacillin in combination with the penem {beta}-lactamase inhibitor BLI-489. |
| AID340725 | Antimicrobial activity against Enterobacter isolates producing extended-spectrum beta-lactamase CTX-M-1 by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8 | Extended-spectrum beta-lactamases of the CTX-M type now in Switzerland. |
| AID761212 | Antibacterial activity against Klebsiella pneumoniae expressing defined beta-lactamase by broth microdilution method | 2013 | Journal of medicinal chemistry, Jul-11, Volume: 56, Issue:13 | Pyridone-conjugated monobactam antibiotics with gram-negative activity. |
| AID583094 | Activity of Escherichia coli XL1-Blue wild-type VIM-2 beta-lactamase by spectrophotometer | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | Mutational analysis of VIM-2 reveals an essential determinant for metallo-beta-lactamase stability and folding. |
| AID556690 | Antimicrobial activity against multidrug resistant Enterobacter aerogenes ATCC 15038 by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Occurrence of efflux mechanism and cephalosporinase variant in a population of Enterobacter aerogenes and Klebsiella pneumoniae isolates producing extended-spectrum beta-lactamases. |
| AID373206 | Antimicrobial activity against Bacillus clausii OC by agar-dilution technique | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Molecular and biochemical characterization of the chromosome-encoded class A beta-lactamase BCL-1 from Bacillus clausii. |
| AID554387 | Antimicrobial activity against ampicillin- and ticarcillin-resistant Pseudomonas aeruginosa FE60 mutant transformed with pAGH97 carrying mexXY operon by twofold macrodilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Efflux unbalance in Pseudomonas aeruginosa isolates from cystic fibrosis patients. |
| AID573186 | Antimicrobial activity against Pseudomonas aeruginosa PAO1 biofilm by Etest method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Azithromycin in Pseudomonas aeruginosa biofilms: bactericidal activity and selection of nfxB mutants. |
| AID285441 | Antimicrobial activity against Escherichia coli DH10B after 18 hrs by disk diffusion method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Chromosome-encoded narrow-spectrum Ambler class A beta-lactamase GIL-1 from Citrobacter gillenii. |
| AID368475 | Antibacterial activity against Pseudomonas aeruginosa HPA101-1477 producing beta lactamase IMP1 by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID573187 | Antimicrobial activity against mutS::lox-deficient Pseudomonas aeruginosa PAOMS biofilm by Etest method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Azithromycin in Pseudomonas aeruginosa biofilms: bactericidal activity and selection of nfxB mutants. |
| AID534306 | Antimicrobial activity against metallo-beta-lactamase-negative Pseudomonas aeruginosa isolate PA509 | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | First survey of metallo-beta-lactamases in clinical isolates of Pseudomonas aeruginosa in a German university hospital. |
| AID529665 | Activity of Pseudomonas aeruginosa COL-1 beta-lactamase VIM-2 relative to cephaloridine | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | VIM-15 and VIM-16, two new VIM-2-like metallo-beta-lactamases in Pseudomonas aeruginosa isolates from Bulgaria and Germany. |
| AID574434 | Antimicrobial activity against Escherichia coli isolate 544 expressing beta-lactamase KPC2, TEM and PFGE cluster 4 isolated from abscess of patient by vitek-2 method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Carbapenem-resistant KPC-2-producing Escherichia coli in a Tel Aviv Medical Center, 2005 to 2008. |
| AID368490 | Ratio of Kcat to Km of Klebsiella pneumoniae SHV1 assessed as drug hydrolysis by spectrophotometry | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID546167 | Antimicrobial activity against AmpC overproducing Pseudomonas aeruginosa isolate Pae-beta-07 with PDC-2 variant by Etest | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Extended-spectrum cephalosporinases in Pseudomonas aeruginosa. |
| AID556660 | Antimicrobial activity against multidrug resistant Enterobacter aerogenes isolate 15 by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Occurrence of efflux mechanism and cephalosporinase variant in a population of Enterobacter aerogenes and Klebsiella pneumoniae isolates producing extended-spectrum beta-lactamases. |
| AID324866 | Antimicrobial activity against Acinetobacter baumannii A24D after 4 days in presence of efflux pump inhibitor phenyl-arginine-beta-naphthylamide by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Tigecycline Efflux as a Mechanism for Nonsusceptibility in Acinetobacter baumannii. |
| AID368484 | Antibacterial activity against Pseudomonas aeruginosa 18SH producing beta lactamase AmpC by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID405082 | Antimicrobial activity against Escherichia coli 33587-TC9 by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | Biochemical characterization of PER-2 and genetic environment of blaPER-2. |
| AID528526 | Antimicrobial activity against penicillin-resistant Streptococcus agalactiae B7 by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | First molecular characterization of group B streptococci with reduced penicillin susceptibility. |
| AID519005 | Antimicrobial activity against Escherichia coli HB101 expressing recombinant plasmid encoded TEM-149 by broth macrodilution method | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | E240V substitution increases catalytic efficiency toward ceftazidime in a new natural TEM-type extended-spectrum beta-lactamase, TEM-149, from Enterobacter aerogenes and Serratia marcescens clinical isolates. |
| AID532172 | Antimicrobial activity against aac(6')-Ib-cr-negative Enterobacter cloacae SH39 harboring GyrA S83I, ParC S80I mutant, wild-type GyrB and qnrA genes by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | High prevalence of plasmid-mediated quinolone resistance genes qnr and aac(6')-Ib-cr in clinical isolates of Enterobacteriaceae from nine teaching hospitals in China. |
| AID560078 | Antimicrobial activity against Pseudomonas aeruginosa isolate 956 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | In vitro activity of ceftaroline alone and in combination against clinical isolates of resistant gram-negative pathogens, including beta-lactamase-producing Enterobacteriaceae and Pseudomonas aeruginosa. |
| AID285573 | Antimicrobial activity against Pseudomonas aeruginosa P21.21 tracheal isolates from mechanically ventilated tuberculosis patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID285628 | Antimicrobial activity against Pseudomonas aeruginosa 9A10 tracheal isolates from mechanically ventilated chronic respiratory insufficiency patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID499057 | Antimicrobial activity against Escherichia coli PU102T expressing TEM-1, CTX-M-14, CMY-2 by CLSI method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Phenotypic and genotypic characterization of Enterobacteriaceae with decreased susceptibility to carbapenems: results from large hospital-based surveillance studies in China. |
| AID508299 | Inhibition of PBP5 in penicillin-resistant Enterococcus faecium D63r membranes assessed as inhibition of fluorescent ampicillin binding after 20 mins at 37 degC | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2 | Interaction of ceftobiprole with the low-affinity PBP 5 of Enterococcus faecium. |
| AID546412 | Antimicrobial activity against Pseudomonas aeruginosa isolate Pae-beta-29 with PDC-8 variant by Etest | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Extended-spectrum cephalosporinases in Pseudomonas aeruginosa. |
| AID571216 | Antimicrobial activity against Pseudomonas aeruginosa isolate TX291 obtained from patient with non-cystic fibrosis by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Role of ampD homologs in overproduction of AmpC in clinical isolates of Pseudomonas aeruginosa. |
| AID531586 | Antibacterial activity against Morganella morganii obtained from complicated skin and skin structure infections by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro activity of ceftobiprole against pathogens from two phase 3 clinical trials of complicated skin and skin structure infections. |
| AID531780 | Antibacterial activity against Pseudomonas aeruginosa obtained from complicated skin and skin structure infections by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro activity of ceftobiprole against pathogens from two phase 3 clinical trials of complicated skin and skin structure infections. |
| AID498804 | Antimicrobial activity against carbapenem-resistant Klebsiella pneumoniae ZJ70 deficient in KPC-2, SHV-11, CTX-M-14, ompK35/36 by CLSI method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Phenotypic and genotypic characterization of Enterobacteriaceae with decreased susceptibility to carbapenems: results from large hospital-based surveillance studies in China. |
| AID508485 | Antimicrobial activity against Pseudomonas aeruginosa isolate BU-43038 producing metallo-beta-lactamase VIM2 by Etest | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Molecular epidemiology of metallo-beta-lactamase-producing Pseudomonas aeruginosa isolates from Norway and Sweden shows import of international clones and local clonal expansion. |
| AID368488 | Ratio of Kcat to Km of Escherichia coli TEM1 assessed as drug hydrolysis by spectrophotometry relative to cephaloridine | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID564216 | Antimicrobial activity against Acinetobacter baumannii ATCC 19606 harboring plasmid PH98 by Etest method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | OXA-143, a novel carbapenem-hydrolyzing class D beta-lactamase in Acinetobacter baumannii. |
| AID535717 | Ratio of Kcat to Km for Escherichia coli TOP10 beta-lactamase AmpC-B2 | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Role of the Ser-287-Asn replacement in the hydrolysis spectrum extension of AmpC beta-lactamases in Escherichia coli. |
| AID556355 | Antimicrobial activity against Salmonella enterica serotype concord expressing extended-spectrum beta-lactamase CTX-M-15 by disc diffusion method | 2009 | Antimicrobial agents and chemotherapy, 05, Volume: 53, Issue:5 | Chromosomal integration of the extended-spectrum beta-lactamase gene blaCTX-M-15 in Salmonella enterica serotype Concord isolates from internationally adopted children. |
| AID558039 | Antimicrobial activity against blaKPC-positive Klebsiella pneumoniae S2 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Genetic organization of transposase regions surrounding blaKPC carbapenemase genes on plasmids from Klebsiella strains isolated in a New York City hospital. |
| AID565526 | Antibacterial activity against mexB, mexY and mexD expressing Pseudomonas aeruginosa isolate Paebeta-09 harboring A residue at 105 position in PDC- 2 and insertion of ISPa27 sequence in OprD gene by Etest method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Molecular epidemiology and mechanisms of carbapenem resistance in Pseudomonas aeruginosa. |
| AID1373307 | Antimicrobial activity against Escherichia coli expressing beta-lactamase NDM-5 by CLSI broth microdilution method | 2018 | Bioorganic & medicinal chemistry letters, 02-15, Volume: 28, Issue:4 | Optimization of novel monobactams with activity against carbapenem-resistant Enterobacteriaceae - Identification of LYS228. |
| AID285442 | Activity of Citrobacter gillenii CIP 106783 Beta-lactamase GIL1 expressed in Escherichia coli DH10B | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Chromosome-encoded narrow-spectrum Ambler class A beta-lactamase GIL-1 from Citrobacter gillenii. |
| AID544684 | Antimicrobial activity against Citrobacter freundii clinical isolate after 18 to 22 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Establishment of in vitro susceptibility testing methodologies and comparative activities of piperacillin in combination with the penem {beta}-lactamase inhibitor BLI-489. |
| AID518467 | Antimicrobial activity against Stenotrophomonas maltophilia 1AC736 assessed as number of passages required for MIC to rise above 4 times original MIC | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli. |
| AID555216 | Antibacterial activity against Escherichia coli DH5alpha carrying ampC gene of Acinetobacter genomosp. 3 isolate 20 by Etest method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Genetic variability among ampC genes from acinetobacter genomic species 3. |
| AID554989 | Antibacterial activity against Acinetobacter genomosp. 3 isolate 60 by Etest method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Genetic variability among ampC genes from acinetobacter genomic species 3. |
| AID499056 | Antimicrobial activity against carbapenem-resistant Escherichia coli PU102 deficient in TEM-1, CTX-M-14, CMY-2, aac(6')-Ib, ompC DEc, ompF by CLSI method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Phenotypic and genotypic characterization of Enterobacteriaceae with decreased susceptibility to carbapenems: results from large hospital-based surveillance studies in China. |
| AID557206 | Creatinine clearance in critically ill patient with ventilator-associated pneumoniae at 2 g/kg administered as 0.5 or 3 hr infusion every 12 hrs | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Population pharmacokinetics of high-dose, prolonged-infusion cefepime in adult critically ill patients with ventilator-associated pneumonia. |
| AID373029 | Antimicrobial activity against imipenem and meropenem-resistant Acinetobacter baumannii isolate PUA7 by CLSI agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Molecular epidemiology of clinical isolates of carbapenem-resistant Acinetobacter spp. from Chinese hospitals. |
| AID542057 | Antibacterial activity against Klebsiella pneumoniae D expressing CTX-M group 1 beta-lactamase by Etest method in presence of clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Nationwide survey of CTX-M-type extended-spectrum beta-lactamases among Klebsiella pneumoniae isolates in Slovenian hospitals. |
| AID528817 | Antimicrobial activity against carbapenem-resistant Enterobacter cloacae isolated from ICU patient urine assessed as resistant isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Antimicrobial-resistant pathogens in intensive care units in Canada: results of the Canadian National Intensive Care Unit (CAN-ICU) study, 2005-2006. |
| AID541013 | Antimicrobial activity against Burkholderia cenocepacia 5007902 expressing beta-lactamase PenB4 | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Naturally occurring Class A ss-lactamases from the Burkholderia cepacia complex. |
| AID565506 | Antibacterial activity against oprD, mexB, mexY and mexD expressing Pseudomonas aeruginosa isolate Paebeta-24 harboring A residue at 105 position in PDC- 5 by Etest method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Molecular epidemiology and mechanisms of carbapenem resistance in Pseudomonas aeruginosa. |
| AID522024 | Antimicrobial activity against Escherichia coli isolate J53 harboring pCF containing beta-lactamase OXA-48 located within transposon Tn1999 by Etest method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Spread of OXA-48-encoding plasmid in Turkey and beyond. |
| AID524748 | Antimicrobial activity against Escherichia coli GB20 harboring V27A, Q38R, A77V, N114D, A140S, P167S, D288N mutations in beta lactamase CTX-M-1 by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Mutational events in cefotaximase extended-spectrum beta-lactamases of the CTX-M-1 cluster involved in ceftazidime resistance. |
| AID524744 | Antimicrobial activity against Escherichia coli GB20 harboring V27A, Q38R mutations in beta lactamase CTX-3 by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Mutational events in cefotaximase extended-spectrum beta-lactamases of the CTX-M-1 cluster involved in ceftazidime resistance. |
| AID520780 | Antibacterial activity against Escherichia coli EC600 transconjugant harboring beta-lactamase KPC-2 by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Emergence of Serratia marcescens, Klebsiella pneumoniae, and Escherichia coli Isolates possessing the plasmid-mediated carbapenem-hydrolyzing beta-lactamase KPC-2 in intensive care units of a Chinese hospital. |
| AID534899 | Antimicrobial activity against Citrobacter with nonderepressed AmpC beta-lactamsae by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activity of doripenem, a carbapenem for the treatment of challenging infections caused by gram-negative bacteria, against recent clinical isolates from the United States. |
| AID495793 | Antimicrobial activity against Escherichia coli DH10B by Etest | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Novel ambler class A carbapenem-hydrolyzing beta-lactamase from a Pseudomonas fluorescens isolate from the Seine River, Paris, France. |
| AID283533 | Antibacterial activity against Pseudomonas aeruginosa FE57 with inactivated rplY gene by microdilution method | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3 | Cumulative effects of several nonenzymatic mechanisms on the resistance of Pseudomonas aeruginosa to aminoglycosides. |
| AID563972 | Activity of Klebsiella pneumoniae 05-560 beta-lactamase NDM-1 by spectrophotometry | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Characterization of a new metallo-beta-lactamase gene, bla(NDM-1), and a novel erythromycin esterase gene carried on a unique genetic structure in Klebsiella pneumoniae sequence type 14 from India. |
| AID496007 | Antimicrobial activity against Ceftazidime resistant Pseudomonas aeruginosa isolates by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vitro potency of CXA-101, a novel cephalosporin, against Pseudomonas aeruginosa displaying various resistance phenotypes, including multidrug resistance. |
| AID546408 | Antimicrobial activity against AmpC overproducing Pseudomonas aeruginosa isolate Pae-beta-25 with PDC-6 variant by Etest | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Extended-spectrum cephalosporinases in Pseudomonas aeruginosa. |
| AID1373299 | Antimicrobial activity against Escherichia coli expressing beta-lactamase TEM-10 by CLSI broth microdilution method | 2018 | Bioorganic & medicinal chemistry letters, 02-15, Volume: 28, Issue:4 | Optimization of novel monobactams with activity against carbapenem-resistant Enterobacteriaceae - Identification of LYS228. |
| AID373042 | Antimicrobial activity against imipenem and meropenem-resistant Acinetobacter baumannii isolate ZJ49 by CLSI agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Molecular epidemiology of clinical isolates of carbapenem-resistant Acinetobacter spp. from Chinese hospitals. |
| AID529575 | Activity of Erwinia carotovora subsp. atroseptica DSM 30184 beta-lactamase CAR-1 | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Functional diversity among metallo-beta-lactamases: characterization of the CAR-1 enzyme of Erwinia carotovora. |
| AID531782 | Antibacterial activity against Pseudomonas fluorescens obtained from complicated skin and skin structure infections by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro activity of ceftobiprole against pathogens from two phase 3 clinical trials of complicated skin and skin structure infections. |
| AID368528 | Activity of Enterobacter cloacae 908R AmpC assessed as drug hydrolysis by spectrophotometry relative to cephaloridine | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID567737 | Antimicrobial activity against wild type Pseudomonas aeruginosa ATCC 27853 by broth macrodilution method | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | Differential selection of single-step AmpC or efflux mutants of Pseudomonas aeruginosa by using cefepime, ceftazidime, or ceftobiprole. |
| AID530815 | Antibacterial activity against human urinary Klebsiella pneumoniae UCL-1 harboring plasmid-encoded beta-lactamase OXA-48 by Etest method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Plasmid-encoded carbapenem-hydrolyzing beta-lactamase OXA-48 in an imipenem-susceptible Klebsiella pneumoniae strain from Belgium. |
| AID1318931 | Antibacterial activity against multidrug-resistant/tobramycin-susceptible Pseudomonas aeruginosa isolate 92014 | 2016 | Journal of medicinal chemistry, 09-22, Volume: 59, Issue:18 | Hybrid Antibiotic Overcomes Resistance in P. aeruginosa by Enhancing Outer Membrane Penetration and Reducing Efflux. |
| AID524566 | Antimicrobial activity against Shigella sonnei isolate AM20369 by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Identification and characterization of CTX-M-producing Shigella isolates in the United States. |
| AID584556 | Antimicrobial activity against Acinetobacter lwoffii isolate C expressing beta-lactamase OXA-164 isolated from tracheal secretion of patient by vitek 2 system | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | In vivo selection of a missense mutation in adeR and conversion of the novel blaOXA-164 gene into blaOXA-58 in carbapenem-resistant Acinetobacter baumannii isolates from a hospitalized patient. |
| AID567312 | Antimicrobial activity against SHV-12 ESBL producing Pseudomonas aeruginosa isolate 2203 isolated from burn patient by broth microdilution method in presence of beta-lactamase inhibitor clavulanic acid | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Acquisition of a transposon encoding extended-spectrum beta-lactamase SHV-12 by Pseudomonas aeruginosa isolates during the clinical course of a burn patient. |
| AID567750 | Antimicrobial activity against Pseudomonas aeruginosa OC 11678 expressing 71 fold elevated mexX expression and 43 fold elevated mexY expression by broth macrodilution method | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | Differential selection of single-step AmpC or efflux mutants of Pseudomonas aeruginosa by using cefepime, ceftazidime, or ceftobiprole. |
| AID571938 | Antimicrobial activity against Escherichia coli MC4100 harboring promoter hybrid 1 and active promoter P2 in beta-lactamase GES-1 by Etest | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Relative strengths of the class 1 integron promoter hybrid 2 and the combinations of strong and hybrid 1 with an active p2 promoter. |
| AID533874 | Antibacterial activity against penicillin-nonsusceptible Streptococcus pneumoniae isolate by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | In vitro activity of ceftaroline against Streptococcus pneumoniae isolates exhibiting resistance to penicillin, amoxicillin, and cefotaxime. |
| AID556677 | Antimicrobial activity against multidrug resistant Klebsiella pneumoniae isolate 4 by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Occurrence of efflux mechanism and cephalosporinase variant in a population of Enterobacter aerogenes and Klebsiella pneumoniae isolates producing extended-spectrum beta-lactamases. |
| AID517959 | Antimicrobial activity against Acinetobacter sp. by broth dilution method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli. |
| AID584838 | Antimicrobial activity against Escherichia coli DH10B harboring recombinant Aeromonas allosaccharophila AL-1 beta-lactamase PER2 by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | PER-6, an extended-spectrum beta-lactamase from Aeromonas allosaccharophila. |
| AID368536 | Activity of Providencia stuartii AmpC assessed as drug hydrolysis by spectrophotometry relative to cephaloridine | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID520882 | Antibacterial activity against Escherichia coli TOP10 by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Characterization of a naturally occurring class D beta-lactamase from Achromobacter xylosoxidans. |
| AID559687 | Antibacterial activity against ESBL-positive Escherichia coli Top10 harboring plasmid AT517 | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | GES-11, a novel integron-associated GES variant in Acinetobacter baumannii. |
| AID560073 | Antimicrobial activity against Enterobacter cloacae isolate 4073 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | In vitro activity of ceftaroline alone and in combination against clinical isolates of resistant gram-negative pathogens, including beta-lactamase-producing Enterobacteriaceae and Pseudomonas aeruginosa. |
| AID571934 | Antimicrobial activity against Escherichia coli MC4100 harboring promoter hybrid 1 in beta-lactamase GES-1 by Etest | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Relative strengths of the class 1 integron promoter hybrid 2 and the combinations of strong and hybrid 1 with an active p2 promoter. |
| AID528984 | Antimicrobial activity against Haemophilus influenzae isolated from ICU patient respiratory tract assessed as resistant isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Antimicrobial-resistant pathogens in intensive care units in Canada: results of the Canadian National Intensive Care Unit (CAN-ICU) study, 2005-2006. |
| AID520389 | Ratio of Kcat to Km for Pseudomonas aeruginosa COL-1 metallo-beta lactamase VIM-2 over Kcat to Km for Pseudomonas aeruginosa M5109 metallo-beta-lactamase VIM-11 | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Biochemical characterization of metallo-beta-lactamase VIM-11 from a Pseudomonas aeruginosa clinical strain. |
| AID495808 | Antimicrobial activity against Escherichia coli DH5alpha 2878 transformant expressing beta-lactamase VIM-19 by microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Novel VIM metallo-beta-lactamase variant from clinical isolates of Enterobacteriaceae from Algeria. |
| AID582976 | Antimicrobial activity against ampD::lox and nagZ::lox gene-deficient Pseudomonas aeruginosa PAO1 harboring dacB gene by Etest method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | NagZ inactivation prevents and reverts beta-lactam resistance, driven by AmpD and PBP 4 mutations, in Pseudomonas aeruginosa. |
| AID285691 | Antimicrobial susceptibility of Citrobacter freundii CF6010 isolate expressing carbapenemase KPC2 | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | First identification of Pseudomonas aeruginosa isolates producing a KPC-type carbapenem-hydrolyzing beta-lactamase. |
| AID322315 | Antibacterial activity against CTX-M group 1 enzyme producing Escherichia coli isolates assessed as percent nonsusceptible isolates by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Spread of extended-spectrum beta-lactamase CTX-M-producing escherichia coli clinical isolates in community and nosocomial environments in Portugal. |
| AID519642 | Antimicrobial activity against Escherichia coli EPI300 harboring pCC1 carrying beta-lactamase CTX-M-42 Pro167Thr mutant gene by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Convergent in vivo and in vitro selection of ceftazidime resistance mutations at position 167 of CTX-M-3 beta-lactamase in hypermutable Escherichia coli strains. |
| AID428273 | Antimicrobial activity against carbapenemase producing Enterobacter sp. assessed as susceptible isolates by CLSI breakpoint assay | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | Antimicrobial activities of tigecycline and other broad-spectrum antimicrobials tested against serine carbapenemase- and metallo-beta-lactamase-producing Enterobacteriaceae: report from the SENTRY Antimicrobial Surveillance Program. |
| AID528844 | Antimicrobial activity against penicillin-resistant Streptococcus pneumoniae assessed as resistant isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Antimicrobial-resistant pathogens in intensive care units in Canada: results of the Canadian National Intensive Care Unit (CAN-ICU) study, 2005-2006. |
| AID573201 | Antimicrobial activity against mutS::lox-deficient Pseudomonas aeruginosa PAOMSA biofilm harboring nfxB T533C mutant gene selected at 4 ug/ml of azithromycin after 2 passages by Etest method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Azithromycin in Pseudomonas aeruginosa biofilms: bactericidal activity and selection of nfxB mutants. |
| AID541513 | Antimicrobial activity against Moraxella catarrhalis clinical isolate after 18 to 22 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Establishment of in vitro susceptibility testing methodologies and comparative activities of piperacillin in combination with the penem {beta}-lactamase inhibitor BLI-489. |
| AID583016 | Antimicrobial activity against OmpC/OmpF porin deficient Escherichia coli HB4 transformed with Escherichia coli EC-6 plasmid carrying AmpC-B2 by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Phenotypic and biochemical comparison of the carbapenem-hydrolyzing activities of five plasmid-borne AmpC β-lactamases. |
| AID584561 | Antimicrobial activity against Acinetobacter lwoffii isolate H expressing beta-lactamase OXA-58 isolated from tracheal secretion of patient by vitek 2 system | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | In vivo selection of a missense mutation in adeR and conversion of the novel blaOXA-164 gene into blaOXA-58 in carbapenem-resistant Acinetobacter baumannii isolates from a hospitalized patient. |
| AID368728 | Ratio of Kcat to Km of Serratia marcescens AmpC assessed as drug hydrolysis by spectrophotometry relative to cephaloridine | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID573340 | Antibacterial activity against ceftazidime-susceptible Citrobacter freundii by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID519314 | Antimicrobial activity against mexXY-OprM-overproducing Pseudomonas aeruginosa PAO1 | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Relationship between antibiotic use and incidence of MexXY-OprM overproducers among clinical isolates of Pseudomonas aeruginosa. |
| AID1143119 | Antibacterial activity against Staphylococcus aureus DSM799 assessed as inhibition of visible growth after 18 hrs incubation by standard broth dilution method | 2014 | Journal of medicinal chemistry, May-22, Volume: 57, Issue:10 | New Ianthelliformisamine derivatives as antibiotic enhancers against resistant Gram-negative bacteria. |
| AID535370 | Antimicrobial activity against Pseudomonas aeruginosa isolated from non-ICU patient assessed as intermediate isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activity of doripenem, a carbapenem for the treatment of challenging infections caused by gram-negative bacteria, against recent clinical isolates from the United States. |
| AID285615 | Antimicrobial activity against Pseudomonas aeruginosa 3D10 tracheal isolates from mechanically ventilated chronic respiratory insufficiency patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID534889 | Antimicrobial activity against Enterobacter cloacae with derepressed AmpC beta-lactamsae assessed as resistant isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activity of doripenem, a carbapenem for the treatment of challenging infections caused by gram-negative bacteria, against recent clinical isolates from the United States. |
| AID529897 | Antimicrobial activity against Leptospira interrogans serovar Pyrogenes isolate 5 by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Antimicrobial susceptibilities of geographically diverse clinical human isolates of Leptospira. |
| AID429079 | Antibacterial activity against Klebsiella pneumoniae Greece producing KPC-2 beta-lactamase by E test method | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | Plasmid-mediated carbapenem-hydrolyzing beta-lactamase KPC-2 in Klebsiella pneumoniae isolate from Greece. |
| AID1592959 | Antibacterial activity against multi-drug resistant Klebsiella pneumoniae NMI 2697/14 assessed as reduction in microbial growth incubated for 20 hrs | 2019 | European journal of medicinal chemistry, Apr-15, Volume: 168 | Microwave-assisted solid-phase synthesis of antisense acpP peptide nucleic acid-peptide conjugates active against colistin- and tigecycline-resistant E. coli and K. pneumoniae. |
| AID535852 | Antimicrobial activity against aac(6')-Ib-cr-negative Enterobacter cloacae FJ67T harboring qnrS gene by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | High prevalence of plasmid-mediated quinolone resistance genes qnr and aac(6')-Ib-cr in clinical isolates of Enterobacteriaceae from nine teaching hospitals in China. |
| AID556654 | Antimicrobial activity against multidrug resistant Enterobacter aerogenes isolate 9 by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Occurrence of efflux mechanism and cephalosporinase variant in a population of Enterobacter aerogenes and Klebsiella pneumoniae isolates producing extended-spectrum beta-lactamases. |
| AID519182 | Antimicrobial activity against MexXY-OprM-overproducing Pseudomonas aeruginosa PAO1 harboring MexY agrW mutant and MexZ mutant gene selected after 0.25 ug/ml of ciprofloxacin exposure | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Relationship between antibiotic use and incidence of MexXY-OprM overproducers among clinical isolates of Pseudomonas aeruginosa. |
| AID524573 | Antimicrobial activity against Shigella isolate DH-26336 by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Identification and characterization of CTX-M-producing Shigella isolates in the United States. |
| AID521350 | Antimicrobial activity against Streptococcus pneumoniae isolate 40 obtained from blood of patient | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Highly variable penicillin resistance determinants PBP 2x, PBP 2b, and PBP 1a in isolates of two Streptococcus pneumoniae clonal groups, Poland 23F-16 and Poland 6B-20. |
| AID542585 | Antimicrobial activity against plasmid encoded beta-lactamase OXA-58 deficient Acinetobacter radioresistens by CLSI method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Codetection of blaOXA-23-like gene (blaOXA-133) and blaOXA-58 in Acinetobacter radioresistens: report from the SENTRY antimicrobial surveillance program. |
| AID573350 | Antibacterial activity against ceftazidime-nonsusceptible Enterobacter cloacae assessed as susceptible isolates by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID1318901 | Antibacterial activity against multidrug-resistant/tobramycin-susceptible Pseudomonas aeruginosa isolate 86052 | 2016 | Journal of medicinal chemistry, 09-22, Volume: 59, Issue:18 | Hybrid Antibiotic Overcomes Resistance in P. aeruginosa by Enhancing Outer Membrane Penetration and Reducing Efflux. |
| AID499055 | Antimicrobial activity against Escherichia coli PU101T expressing CMY-2 by CLSI method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Phenotypic and genotypic characterization of Enterobacteriaceae with decreased susceptibility to carbapenems: results from large hospital-based surveillance studies in China. |
| AID587528 | Antimicrobial activity against carbapenemases KPC-producing Klebsiella pneumoniae VA-406 infected in sc dosed CD-1 mouse in presence of 1 ug/ml NXL104 beta-lactamase inhibitor | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1 | Evaluation of ceftazidime and NXL104 in two murine models of infection due to KPC-producing Klebsiella pneumoniae. |
| AID572128 | Antimicrobial activity against Acinetobacter baumannii nu clonal group isolate 31 expressing ampC, ompA, adeB, adeM, aadB, aadA2 by Etest method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Correlation of antimicrobial resistance with beta-lactamases, the OmpA-like porin, and efflux pumps in clinical isolates of Acinetobacter baumannii endemic to New York City. |
| AID560131 | Activity of recombinant beta-lactamase RTG4 expressed in Escherichia coli TOP10 by nitrocefin hydrolysis assay | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Genetic and biochemical characterization of the first extended-spectrum CARB-type beta-lactamase, RTG-4, from Acinetobacter baumannii. |
| AID520810 | Antimicrobial activity against SHV-5 producing Klebsiella pneumoniae transconjugants/transformants with PFGE pulsotype D by Etest | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Multiclonal outbreak of Klebsiella pneumoniae producing extended-spectrum beta-lactamase CTX-M-2 and novel variant CTX-M-59 in a neonatal intensive care unit in Brazil. |
| AID1318937 | Antibacterial activity against multidrug-resistant/tobramycin-susceptible Pseudomonas aeruginosa isolate 85322 | 2016 | Journal of medicinal chemistry, 09-22, Volume: 59, Issue:18 | Hybrid Antibiotic Overcomes Resistance in P. aeruginosa by Enhancing Outer Membrane Penetration and Reducing Efflux. |
| AID405823 | Antimicrobial activity against Acinetobacter baumannii 9043 isolate harboring bla IMP-1 carrying integron In86 containing aminoglycoside resistance gene aac(6')-3 | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | Characterization of an integron carrying blaIMP-1 and a new aminoglycoside resistance gene, aac(6')-31, and its dissemination among genetically unrelated clinical isolates in a Brazilian hospital. |
| AID560115 | Antibacterial activity against Escherichia coli TOP10 harboring beta-lactamase RTG3 gene by Etest method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Genetic and biochemical characterization of the first extended-spectrum CARB-type beta-lactamase, RTG-4, from Acinetobacter baumannii. |
| AID532208 | Antimicrobial activity against Escherichia coli J53 harboring wild-type GyrA, ParC, GyrB genes by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | High prevalence of plasmid-mediated quinolone resistance genes qnr and aac(6')-Ib-cr in clinical isolates of Enterobacteriaceae from nine teaching hospitals in China. |
| AID534627 | Antimicrobial activity against Non-ESBL Escherichia coli assessed as susceptible isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activity of doripenem, a carbapenem for the treatment of challenging infections caused by gram-negative bacteria, against recent clinical isolates from the United States. |
| AID519981 | Ratio of Kcat to Km for Klebsiella pneumoniae Beta-Lactamase SHV-1 | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Biochemical characterization of SHV-55, an extended-spectrum class A beta-lactamase from Klebsiella pneumoniae. |
| AID499128 | Antimicrobial activity against Pseudomonas aeruginosa OC 4351 infected in immunocompromized SKH1 mouse assessed as log change in bacterial colony forming units at 25 mg/kg/day, sc | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vivo activity of ceftobiprole in murine skin infections due to Staphylococcus aureus and Pseudomonas aeruginosa. |
| AID511397 | Antibacterial activity against Acinetobacter baumannii by broth dilution method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Comparative in vitro activities of nemonoxacin (TG-873870), a novel nonfluorinated quinolone, and other quinolones against clinical isolates. |
| AID761210 | Antibacterial activity against Klebsiella pneumoniae expressing KPC by broth microdilution method | 2013 | Journal of medicinal chemistry, Jul-11, Volume: 56, Issue:13 | Pyridone-conjugated monobactam antibiotics with gram-negative activity. |
| AID301088 | Antibacterial activity against methicillin-resistant Staphylococcus aureus SMITH after 20 hrs by agar dilution method | 2007 | Bioorganic & medicinal chemistry, Nov-01, Volume: 15, Issue:21 | A novel series of parenteral cephalosporins exhibiting potent activities against Pseudomonas aeruginosa and other Gram-negative pathogens: synthesis and structure-activity relationships. |
| AID573189 | Antimicrobial activity against mucA::lox, mutS::lox-deficient Pseudomonas aeruginosa PAOMSA biofilm by Etest method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Azithromycin in Pseudomonas aeruginosa biofilms: bactericidal activity and selection of nfxB mutants. |
| AID560087 | Bactericidal activity against Pseudomonas aeruginosa isolate 1019 at 1/4 times MIC after 24 hrs by time kill analysis | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | In vitro activity of ceftaroline alone and in combination against clinical isolates of resistant gram-negative pathogens, including beta-lactamase-producing Enterobacteriaceae and Pseudomonas aeruginosa. |
| AID520705 | Antibacterial activity against Acinetobacter baumannii phenotype 1 by disk diffusion method | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Carbapenem-resistant Acinetobacter baumannii isolates from Tunisia producing the OXA-58-like carbapenem-hydrolyzing oxacillinase OXA-97. |
| AID534642 | Antimicrobial activity against Non-ESBL Klebsiella pneumoniae by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activity of doripenem, a carbapenem for the treatment of challenging infections caused by gram-negative bacteria, against recent clinical isolates from the United States. |
| AID554388 | Antimicrobial activity against ampicillin- and ticarcillin-resistant Pseudomonas aeruginosa FE60 mutant transformed with pAGH97 carrying mexXY F29S mutant by twofold macrodilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Efflux unbalance in Pseudomonas aeruginosa isolates from cystic fibrosis patients. |
| AID554990 | Antibacterial activity against Acinetobacter genomosp. 3 isolate 65 by Etest method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Genetic variability among ampC genes from acinetobacter genomic species 3. |
| AID324872 | Antimicrobial activity against Acinetobacter baumannii C75 by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Tigecycline Efflux as a Mechanism for Nonsusceptibility in Acinetobacter baumannii. |
| AID534924 | Antimicrobial activity against Ceftazidime susceptible Serratia marcescens assessed as susceptible isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activity of doripenem, a carbapenem for the treatment of challenging infections caused by gram-negative bacteria, against recent clinical isolates from the United States. |
| AID535141 | Antimicrobial activity against imipenem susceptible Pseudomonas aeruginosa assessed as intermediate isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activity of doripenem, a carbapenem for the treatment of challenging infections caused by gram-negative bacteria, against recent clinical isolates from the United States. |
| AID1373288 | Antimicrobial activity against Escherichia coli expressing beta-lactamase KPC-8 by CLSI broth microdilution method | 2018 | Bioorganic & medicinal chemistry letters, 02-15, Volume: 28, Issue:4 | Optimization of novel monobactams with activity against carbapenem-resistant Enterobacteriaceae - Identification of LYS228. |
| AID541808 | Antimicrobial activity against Enterococcus durans clinical isolate after 18 to 22 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Establishment of in vitro susceptibility testing methodologies and comparative activities of piperacillin in combination with the penem {beta}-lactamase inhibitor BLI-489. |
| AID582969 | Antimicrobial activity against Pseudomonas aeruginosa PAO1 by Etest method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | NagZ inactivation prevents and reverts beta-lactam resistance, driven by AmpD and PBP 4 mutations, in Pseudomonas aeruginosa. |
| AID531756 | Antibacterial activity against Pseudomonas aeruginosa 2126 harboring pNF225 carrying nfxB by twofold serial dilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Resistance and virulence of Pseudomonas aeruginosa clinical strains overproducing the MexCD-OprJ efflux pump. |
| AID567740 | Antimicrobial activity against Pseudomonas aeruginosa OC 11678 expressing 31 fold elevated AmpC expression by broth macrodilution method | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | Differential selection of single-step AmpC or efflux mutants of Pseudomonas aeruginosa by using cefepime, ceftazidime, or ceftobiprole. |
| AID554984 | Antibacterial activity against Acinetobacter genomosp. 3 isolate 14 by Etest method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Genetic variability among ampC genes from acinetobacter genomic species 3. |
| AID532412 | Antibacterial activity against VIM-2 producing Pseudomonas aeruginosa clone B3 isolate PV-05X-07 by Etest method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | First countrywide survey of acquired metallo-beta-lactamases in gram-negative pathogens in Italy. |
| AID556650 | Antimicrobial activity against multidrug resistant Enterobacter aerogenes isolate 5 by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Occurrence of efflux mechanism and cephalosporinase variant in a population of Enterobacter aerogenes and Klebsiella pneumoniae isolates producing extended-spectrum beta-lactamases. |
| AID571933 | Antimicrobial activity against Escherichia coli MC4100 harboring strong promoter in beta-lactamase GES-1 by Etest | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Relative strengths of the class 1 integron promoter hybrid 2 and the combinations of strong and hybrid 1 with an active p2 promoter. |
| AID534650 | Antimicrobial activity against ESBL producing Klebsiella pneumoniae assessed as susceptible isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activity of doripenem, a carbapenem for the treatment of challenging infections caused by gram-negative bacteria, against recent clinical isolates from the United States. |
| AID573211 | Antimicrobial activity against mucA::lox, mutS::lox-deficient Pseudomonas aeruginosa PAOMSAA biofilm harboring nfxB C89T mutant gene selected at 0.5 ug/ml of azithromycin after 3 passages by Etest method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Azithromycin in Pseudomonas aeruginosa biofilms: bactericidal activity and selection of nfxB mutants. |
| AID571038 | Antimicrobial activity against Pseudomonas aeruginosa isolate PA24 obtained from patient with cystic fibrosis by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Role of ampD homologs in overproduction of AmpC in clinical isolates of Pseudomonas aeruginosa. |
| AID524928 | Antimicrobial activity against Escherichia coli MI1443 harboring N106S mutation in beta lactamase CTX-M-10 by E-test | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Mutational events in cefotaximase extended-spectrum beta-lactamases of the CTX-M-1 cluster involved in ceftazidime resistance. |
| AID535138 | Antimicrobial activity against Ceftazidime non-susceptible Pseudomonas aeruginosa assessed as intermediate isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activity of doripenem, a carbapenem for the treatment of challenging infections caused by gram-negative bacteria, against recent clinical isolates from the United States. |
| AID562578 | Antimicrobial activity against Escherichia coli NO8-1503 harboring blaTEM-168 gene by Etest in presence of clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | TEM-168, a heretofore laboratory-derived TEM beta-lactamase variant found in an Escherichia coli clinical isolate. |
| AID540218 | Clearance in monkey after iv administration | 2005 | Journal of pharmaceutical sciences, Jul, Volume: 94, Issue:7 | Extrapolation of human pharmacokinetic parameters from rat, dog, and monkey data: Molecular properties associated with extrapolative success or failure. |
| AID529574 | Antimicrobial activity against Escherichia coli DH5alpha harboring plasmid BC-SK after 24 hrs by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Functional diversity among metallo-beta-lactamases: characterization of the CAR-1 enzyme of Erwinia carotovora. |
| AID571888 | Antimicrobial activity against ISAba1 linked with the blaOXA-51-type beta-lactamase harboring Acinetobacter baumannii alpha clonal group isolate 8 expressing ampC, ompA, adeB, adeM, aacC1, aadA1 by Etest method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Correlation of antimicrobial resistance with beta-lactamases, the OmpA-like porin, and efflux pumps in clinical isolates of Acinetobacter baumannii endemic to New York City. |
| AID285574 | Antimicrobial activity against Pseudomonas aeruginosa 65.18-1 tracheal isolates from mechanically ventilated tuberculosis patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID279813 | Antimicrobial activity against Escherichia coli DH5-alpha pYW1 transformants expressing KPC2 gene by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2 | Plasmid-mediated KPC-2 in a Klebsiella pneumoniae isolate from China. |
| AID529657 | Activity of Pseudomonas aeruginosa 166301 beta-lactamase VIM-16 | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | VIM-15 and VIM-16, two new VIM-2-like metallo-beta-lactamases in Pseudomonas aeruginosa isolates from Bulgaria and Germany. |
| AID588219 | FDA HLAED, gamma-glutamyl transferase (GGT) increase | 2004 | Current drug discovery technologies, Dec, Volume: 1, Issue:4 | Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. |
| AID541835 | Antimicrobial activity against Streptococcus agalactiae clinical isolate after 18 to 22 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Establishment of in vitro susceptibility testing methodologies and comparative activities of piperacillin in combination with the penem {beta}-lactamase inhibitor BLI-489. |
| AID520802 | Antimicrobial activity against CTX-M-2 producing Klebsiella pneumoniae with PFGE pulsotype J by Etest | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Multiclonal outbreak of Klebsiella pneumoniae producing extended-spectrum beta-lactamase CTX-M-2 and novel variant CTX-M-59 in a neonatal intensive care unit in Brazil. |
| AID534086 | Antibacterial activity against levofloxacin-resistant Streptococcus pneumoniae isolate by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | In vitro activity of ceftaroline against Streptococcus pneumoniae isolates exhibiting resistance to penicillin, amoxicillin, and cefotaxime. |
| AID565721 | Antibacterial activity against oprD, mexB, mexY and mexD expressing Pseudomonas aeruginosa isolate Paebeta-26 harboring T residue at 105 position in PDC- 6 and polymorphic OprD gene by Etest method in presence of cloxacillin | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Molecular epidemiology and mechanisms of carbapenem resistance in Pseudomonas aeruginosa. |
| AID444053 | Renal clearance in human | 2010 | Journal of medicinal chemistry, Feb-11, Volume: 53, Issue:3 | Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. |
| AID1225767 | Antibacterial activity against Klebsiella pneumoniae KP1009 expressing CTX-M-15 by broth microdilution method | 2015 | Journal of medicinal chemistry, May-14, Volume: 58, Issue:9 | Discovery of a Cyclic Boronic Acid β-Lactamase Inhibitor (RPX7009) with Utility vs Class A Serine Carbapenemases. |
| AID322316 | Antibacterial activity against CTX-M group 9 enzyme producing Escherichia coli isolates by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Spread of extended-spectrum beta-lactamase CTX-M-producing escherichia coli clinical isolates in community and nosocomial environments in Portugal. |
| AID584846 | Activity at Aeromonas allosaccharophila AL-1 beta-lactamase PER6 | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | PER-6, an extended-spectrum beta-lactamase from Aeromonas allosaccharophila. |
| AID534192 | Antimicrobial activity against Enterobacter cloacae expressing beta-lactamase KPC-2 and SHV-12 obtained from criticall ill liver transplant recipient by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | KPC-2-producing Enterobacter cloacae and pseudomonas putida coinfection in a liver transplant recipient. |
| AID564526 | Antimicrobial activity against Acinetobacter baumannii AYE expressing VEB-1 gene by Etest method | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | Extended-spectrum cephalosporinase in Acinetobacter baumannii. |
| AID373756 | Antibacterial activity against imipenem-susceptible Acinetobacter baumannii ab20 by broth dilution method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | An OXA-66/OXA-51-like carbapenemase and possibly an efflux pump are associated with resistance to imipenem in Acinetobacter baumannii. |
| AID373049 | Antimicrobial activity against imipenem and meropenem-resistant Acinetobacter baumannii isolate JN45 by CLSI agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Molecular epidemiology of clinical isolates of carbapenem-resistant Acinetobacter spp. from Chinese hospitals. |
| AID560066 | Antimicrobial activity against Escherichia coli isolate 5411 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | In vitro activity of ceftaroline alone and in combination against clinical isolates of resistant gram-negative pathogens, including beta-lactamase-producing Enterobacteriaceae and Pseudomonas aeruginosa. |
| AID532417 | Antibacterial activity against IMP-13 producing Pseudomonas aeruginosa clone C2 isolate NA-14X-12 by Etest method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | First countrywide survey of acquired metallo-beta-lactamases in gram-negative pathogens in Italy. |
| AID285576 | Antimicrobial activity against Pseudomonas aeruginosa 65.18-3 tracheal isolates from mechanically ventilated tuberculosis patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID508725 | Antibacterial activity against carbapenem-resistant Pseudomonas aeruginosa isolate 1E3 PpA2 harboring acquired beta-lactamase OXA-101 by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2 | Activity of a new antipseudomonal cephalosporin, CXA-101 (FR264205), against carbapenem-resistant and multidrug-resistant Pseudomonas aeruginosa clinical strains. |
| AID521825 | Antimicrobial activity against beta-lactam resistant Streptococcus pneumoniae clinical isolate by broth dilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Clonal spread of highly beta-lactam-resistant Streptococcus pneumoniae isolates in Taiwan. |
| AID565712 | Antibacterial activity against oprD, mexB, mexY and mexD expressing Pseudomonas aeruginosa isolate Paebeta-17 harboring A residue at 105 position in PDC- 3 by Etest method in presence of cloxacillin | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Molecular epidemiology and mechanisms of carbapenem resistance in Pseudomonas aeruginosa. |
| AID516139 | Antibacterial activity against Pulsotype F Acinetobacter genomosp. 3 isolate 4 containing IMP-1, OXA-58, ADC-18, ISAba1, ISAba3, IS18, IS1008, intI1 genetic elements by broth micro dilution | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Molecular characterization of beta-lactamase genes and their genetic structures in Acinetobacter genospecies 3 isolates in Taiwan. |
| AID518521 | Antimicrobial activity against Capnocytophaga sputigena CRBIP 17.39 after 2 days by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Characterization of CSP-1, a novel extended-spectrum beta-lactamase produced by a clinical isolate of Capnocytophaga sputigena. |
| AID572136 | Antimicrobial activity against Acinetobacter baumannii eta clonal group isolate 35 expressing ampC, ompA, adeB, adeM by Etest method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Correlation of antimicrobial resistance with beta-lactamases, the OmpA-like porin, and efflux pumps in clinical isolates of Acinetobacter baumannii endemic to New York City. |
| AID532418 | Antibacterial activity against IMP-13 producing Pseudomonas aeruginosa clone C3 isolate PG-12X-03 by Etest method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | First countrywide survey of acquired metallo-beta-lactamases in gram-negative pathogens in Italy. |
| AID373037 | Antimicrobial activity against imipenem and meropenem-resistant Acinetobacter baumannii isolate DL34 by CLSI agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Molecular epidemiology of clinical isolates of carbapenem-resistant Acinetobacter spp. from Chinese hospitals. |
| AID567742 | Antimicrobial activity against Pseudomonas aeruginosa OC 11678 expressing 40 fold elevated AmpC expression by broth macrodilution method | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | Differential selection of single-step AmpC or efflux mutants of Pseudomonas aeruginosa by using cefepime, ceftazidime, or ceftobiprole. |
| AID544966 | Antimicrobial activity against Proteus mirabilis expressing extended-spectrum beta-lactamase by Etest based on multiple determinants | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Characterization and sequence analysis of extended-spectrum-{beta}-lactamase-encoding genes from Escherichia coli, Klebsiella pneumoniae, and Proteus mirabilis isolates collected during tigecycline phase 3 clinical trials. |
| AID499131 | Antimicrobial activity against Pseudomonas aeruginosa OC 4354 infected in immunocompromized SKH1 mouse assessed as log change in bacterial colony forming unit at 6.2 mg/kg/day, sc | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vivo activity of ceftobiprole in murine skin infections due to Staphylococcus aureus and Pseudomonas aeruginosa. |
| AID285644 | Antimicrobial activity against Pseudomonas aeruginosa 15H5 tracheal isolates from mechanically ventilated chronic respiratory insufficiency patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID285673 | Antimicrobial activity against Pseudomonas aeruginosa 24E6 tracheal isolates from mechanically ventilated chronic respiratory insufficiency patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID530324 | Antimicrobial activity against Pseudomonas aeruginosa PAO1 harboring pUCP carrying VIM-13 gene by Etest method | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Characterization of the new metallo-beta-lactamase VIM-13 and its integron-borne gene from a Pseudomonas aeruginosa clinical isolate in Spain. |
| AID584836 | Antimicrobial activity against Escherichia coli DH10B harboring recombinant Aeromonas allosaccharophila AL-1 beta-lactamase PER6 by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | PER-6, an extended-spectrum beta-lactamase from Aeromonas allosaccharophila. |
| AID340731 | Antimicrobial activity against Enterobacter isolates producing extended-spectrum beta-lactamase SHV-ES by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8 | Extended-spectrum beta-lactamases of the CTX-M type now in Switzerland. |
| AID531788 | Antibacterial activity against Klebsiella oxytoca obtained from complicated skin and skin structure infections by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro activity of ceftobiprole against pathogens from two phase 3 clinical trials of complicated skin and skin structure infections. |
| AID543427 | Antimicrobial activity against Escherichia coli XL-1 Blue harboring plasmid CL1920 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Novel chimeric beta-lactamase CTX-M-64, a hybrid of CTX-M-15-like and CTX-M-14 beta-lactamases, found in a Shigella sonnei strain resistant to various oxyimino-cephalosporins, including ceftazidime. |
| AID567308 | Antimicrobial activity against SHV-12 ESBL producing Pseudomonas aeruginosa isolate 2206 isolated from burn patient by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Acquisition of a transposon encoding extended-spectrum beta-lactamase SHV-12 by Pseudomonas aeruginosa isolates during the clinical course of a burn patient. |
| AID495810 | Antimicrobial activity against Escherichia coli harbouring plasmid BK-CMV expressing beta-lactamase VIM-19 by microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Novel VIM metallo-beta-lactamase variant from clinical isolates of Enterobacteriaceae from Algeria. |
| AID573367 | Antibacterial activity against ceftazidime-susceptible Proteus mirabilis by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID522575 | Antimicrobial activity against Escherichia coli isolate 8009989 with AmpC beta-lactamase H296P mutation | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Occurrence of ST23 complex phylogroup A Escherichia coli isolates producing extended-spectrum AmpC beta-lactamase in a French hospital. |
| AID556689 | Antimicrobial activity against multidrug resistant Klebsiella pneumoniae isolate 16 by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Occurrence of efflux mechanism and cephalosporinase variant in a population of Enterobacter aerogenes and Klebsiella pneumoniae isolates producing extended-spectrum beta-lactamases. |
| AID528837 | Antimicrobial activity against vancomycin-resistant Enterococcus sp. isolated from ICU patient urine assessed as resistant isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Antimicrobial-resistant pathogens in intensive care units in Canada: results of the Canadian National Intensive Care Unit (CAN-ICU) study, 2005-2006. |
| AID556675 | Antimicrobial activity against multidrug resistant Klebsiella pneumoniae isolate 2 by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Occurrence of efflux mechanism and cephalosporinase variant in a population of Enterobacter aerogenes and Klebsiella pneumoniae isolates producing extended-spectrum beta-lactamases. |
| AID1373290 | Antimicrobial activity against Escherichia coli expressing beta-lactamase PER-1 by CLSI broth microdilution method | 2018 | Bioorganic & medicinal chemistry letters, 02-15, Volume: 28, Issue:4 | Optimization of novel monobactams with activity against carbapenem-resistant Enterobacteriaceae - Identification of LYS228. |
| AID283547 | Antibacterial activity against Pseudomonas aeruginosa FE60 containing inactivated mexXY gene by microdilution method | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3 | Cumulative effects of several nonenzymatic mechanisms on the resistance of Pseudomonas aeruginosa to aminoglycosides. |
| AID558052 | Antimicrobial activity against blaKPC-positive Klebsiella pneumoniae S15 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Genetic organization of transposase regions surrounding blaKPC carbapenemase genes on plasmids from Klebsiella strains isolated in a New York City hospital. |
| AID499120 | Antimicrobial activity against Pseudomonas aeruginosa OC 4351 infected in immunocompromized SKH1 mouse assessed as lesion volume at 25 mg/kg/day, sc measured after 48 hrs postinfection (Rvb = 2234 mm3) | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vivo activity of ceftobiprole in murine skin infections due to Staphylococcus aureus and Pseudomonas aeruginosa. |
| AID565524 | Antibacterial activity against mexB, mexY and mexD expressing Pseudomonas aeruginosa isolate Paebeta-11 harboring A residue at 105 position in PDC- 2 and insertion of ISPa27 sequence in OprD gene by Etest method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Molecular epidemiology and mechanisms of carbapenem resistance in Pseudomonas aeruginosa. |
| AID495842 | Hydrolytic activity of Escherichia coli DH10B beta-lactamase VIM-2 by microacidimetric method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Novel VIM metallo-beta-lactamase variant from clinical isolates of Enterobacteriaceae from Algeria. |
| AID560088 | Bactericidal activity against Pseudomonas aeruginosa isolate 1037 at 1/4 times MIC after 24 hrs by time kill analysis | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | In vitro activity of ceftaroline alone and in combination against clinical isolates of resistant gram-negative pathogens, including beta-lactamase-producing Enterobacteriaceae and Pseudomonas aeruginosa. |
| AID520719 | Antibacterial activity against Escherichia coli DH10B | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Carbapenem-resistant Acinetobacter baumannii isolates from Tunisia producing the OXA-58-like carbapenem-hydrolyzing oxacillinase OXA-97. |
| AID518461 | Antimicrobial activity against Enterobacter cloacae S4741B assessed as number of passages required for MIC to rise above 4 times original MIC | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli. |
| AID1373293 | Antimicrobial activity against Escherichia coli expressing beta-lactamase SHV-12 by CLSI broth microdilution method | 2018 | Bioorganic & medicinal chemistry letters, 02-15, Volume: 28, Issue:4 | Optimization of novel monobactams with activity against carbapenem-resistant Enterobacteriaceae - Identification of LYS228. |
| AID519639 | Antimicrobial activity against ceftazidime-resistant Escherichia coli Irk2322 harboring beta-lactamase CTX-M-42 Pro167Thr mutant gene by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Convergent in vivo and in vitro selection of ceftazidime resistance mutations at position 167 of CTX-M-3 beta-lactamase in hypermutable Escherichia coli strains. |
| AID531750 | Antibacterial activity against Pseudomonas aeruginosa FK06 harboring pNF225 carrying nfxB by twofold serial dilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Resistance and virulence of Pseudomonas aeruginosa clinical strains overproducing the MexCD-OprJ efflux pump. |
| AID510508 | Antibacterial activity against Acinetobacter calcoaceticus/baumannii complex isolate MC1AC9-26 expressing KPC beta lactamase | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Detection of KPC in Acinetobacter spp. in Puerto Rico. |
| AID541019 | Antimicrobial activity against Escherichia coli TOP10 | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Naturally occurring Class A ss-lactamases from the Burkholderia cepacia complex. |
| AID283543 | Antibacterial activity against Pseudomonas aeruginosa FE57UZ with inactivated rplY, galU and mexZ genes by microdilution method | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3 | Cumulative effects of several nonenzymatic mechanisms on the resistance of Pseudomonas aeruginosa to aminoglycosides. |
| AID508478 | Antimicrobial activity against Pseudomonas aeruginosa isolate U9-19005 producing metallo-beta-lactamase VIM2 by Etest | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Molecular epidemiology of metallo-beta-lactamase-producing Pseudomonas aeruginosa isolates from Norway and Sweden shows import of international clones and local clonal expansion. |
| AID571042 | Antimicrobial activity against Pseudomonas aeruginosa isolate GB57 obtained from patient with non-cystic fibrosis by Etest | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Role of ampD homologs in overproduction of AmpC in clinical isolates of Pseudomonas aeruginosa. |
| AID508727 | Antibacterial activity against carbapenem-resistant Pseudomonas aeruginosa isolate 1D5 SA1 harboring acquired beta-lactamase VIM-2 by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2 | Activity of a new antipseudomonal cephalosporin, CXA-101 (FR264205), against carbapenem-resistant and multidrug-resistant Pseudomonas aeruginosa clinical strains. |
| AID525509 | Antimicrobial activity against Pseudomonas aeruginosa isolated from infected patient by Etest method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Clinical pharmacodynamics of cefepime in patients infected with Pseudomonas aeruginosa. |
| AID368515 | Ratio of Kcat to Km of Pseudomonas aeruginosa IMP1 assessed as drug hydrolysis by spectrophotometry | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID1225768 | Antibacterial activity against Klebsiella pneumoniae KP1011 expressing SHV-5 by broth microdilution method | 2015 | Journal of medicinal chemistry, May-14, Volume: 58, Issue:9 | Discovery of a Cyclic Boronic Acid β-Lactamase Inhibitor (RPX7009) with Utility vs Class A Serine Carbapenemases. |
| AID496008 | Antimicrobial activity against piperacillin-tazobactam resistant Pseudomonas aeruginosa isolates by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vitro potency of CXA-101, a novel cephalosporin, against Pseudomonas aeruginosa displaying various resistance phenotypes, including multidrug resistance. |
| AID567280 | Activity of Acinetobacter baumannii ADC-11 beta-lactamase | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | Extended-spectrum cephalosporinase in Acinetobacter baumannii. |
| AID541525 | Antimicrobial activity against methicillin-susceptible Staphylococcus epidermidis clinical isolate after 18 to 22 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Establishment of in vitro susceptibility testing methodologies and comparative activities of piperacillin in combination with the penem {beta}-lactamase inhibitor BLI-489. |
| AID546172 | Antimicrobial activity against AmpC overproducing Pseudomonas aeruginosa isolate Pae-beta-12 with PDC-2 variant by Etest | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Extended-spectrum cephalosporinases in Pseudomonas aeruginosa. |
| AID565544 | Antibacterial activity against mexB, mexY and mexD expressing Pseudomonas aeruginosa isolate Paebeta-08 harboring A residue at 105 position in PDC- 2 and insertion of ISPa27 sequence in OprD gene by Etest method in presence of cloxacillin | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Molecular epidemiology and mechanisms of carbapenem resistance in Pseudomonas aeruginosa. |
| AID761207 | Antibacterial activity against Escherichia coli expressing defined beta-lactamase by broth microdilution method | 2013 | Journal of medicinal chemistry, Jul-11, Volume: 56, Issue:13 | Pyridone-conjugated monobactam antibiotics with gram-negative activity. |
| AID1373315 | Antimicrobial activity against Escherichia coli expressing beta-lactamase Oxa-10 by CLSI broth microdilution method | 2018 | Bioorganic & medicinal chemistry letters, 02-15, Volume: 28, Issue:4 | Optimization of novel monobactams with activity against carbapenem-resistant Enterobacteriaceae - Identification of LYS228. |
| AID1318922 | Antibacterial activity against multidrug/extremely drug-resistant/colistin-susceptible Pseudomonas aeruginosa isolate 262-101856 | 2016 | Journal of medicinal chemistry, 09-22, Volume: 59, Issue:18 | Hybrid Antibiotic Overcomes Resistance in P. aeruginosa by Enhancing Outer Membrane Penetration and Reducing Efflux. |
| AID340728 | Antimicrobial activity against Enterobacter isolates producing extended-spectrum beta-lactamase CTX-M-9 by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8 | Extended-spectrum beta-lactamases of the CTX-M type now in Switzerland. |
| AID573210 | Antimicrobial activity against mutS::lox-deficient Pseudomonas aeruginosa PAOMSB biofilm harboring nfxB T77C mutant gene selected at 4 ug/ml of azithromycin after 6 passages by Etest method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Azithromycin in Pseudomonas aeruginosa biofilms: bactericidal activity and selection of nfxB mutants. |
| AID583096 | Antimicrobial activity against Escherichia coli XL1-Blue harboring pLBII-VIM-2 plasmid expressing VIM-2 W87F mutant beta-lactamase by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | Mutational analysis of VIM-2 reveals an essential determinant for metallo-beta-lactamase stability and folding. |
| AID534298 | Antimicrobial activity against Pseudomonas aeruginosa isolate PA500 expressing VIM-1 beta-lactamase | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | First survey of metallo-beta-lactamases in clinical isolates of Pseudomonas aeruginosa in a German university hospital. |
| AID499054 | Antimicrobial activity against carbapenem-resistant Escherichia coli PU101 deficient in TEM-1, CTX-M-14, CMY-2, ompC by CLSI method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Phenotypic and genotypic characterization of Enterobacteriaceae with decreased susceptibility to carbapenems: results from large hospital-based surveillance studies in China. |
| AID524931 | Antimicrobial activity against Escherichia coli MI1443 harboring P167S and D240G mutations in beta lactamase CTX-M-10 by E-test | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Mutational events in cefotaximase extended-spectrum beta-lactamases of the CTX-M-1 cluster involved in ceftazidime resistance. |
| AID556695 | Antimicrobial activity against multidrug resistant Escherichia coli DH5[alpha] harboring pDrive plasmid by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Occurrence of efflux mechanism and cephalosporinase variant in a population of Enterobacter aerogenes and Klebsiella pneumoniae isolates producing extended-spectrum beta-lactamases. |
| AID557205 | Total clearance in critically ill patient with normal renal function at 2 mg/kg administered as single bolus dose | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Population pharmacokinetics of high-dose, prolonged-infusion cefepime in adult critically ill patients with ventilator-associated pneumonia. |
| AID562741 | Antimicrobial activity against Escherichia coli DH5[alpha] by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | New variant of CTX-M-type extended-spectrum beta-lactamases, CTX-M-71, with a Gly238Cys substitution in a Klebsiella pneumoniae isolate from Bulgaria. |
| AID285594 | Antimicrobial activity against Pseudomonas aeruginosa 1A9 tracheal isolates from mechanically ventilated tuberculosis patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID554386 | Antimicrobial activity against mexXY deficient ampicillin- and ticarcillin-resistant Pseudomonas aeruginosa FE60 mutant by twofold macrodilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Efflux unbalance in Pseudomonas aeruginosa isolates from cystic fibrosis patients. |
| AID528527 | Antimicrobial activity against penicillin-resistant Streptococcus agalactiae B8 by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | First molecular characterization of group B streptococci with reduced penicillin susceptibility. |
| AID1079949 | Proposed mechanism(s) of liver damage. [column 'MEC' in source] | |||
| AID564018 | Antibacterial activity against Pseudomonas aeruginosa isolated from wound infection of patient by Etest | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Detection of the novel extended-spectrum beta-lactamase OXA-161 from a plasmid-located integron in Pseudomonas aeruginosa clinical isolates from Spain. |
| AID301080 | Antibacterial activity against Escherichia coli NIHJJC2 after 20 hrs by agar dilution method | 2007 | Bioorganic & medicinal chemistry, Nov-01, Volume: 15, Issue:21 | A novel series of parenteral cephalosporins exhibiting potent activities against Pseudomonas aeruginosa and other Gram-negative pathogens: synthesis and structure-activity relationships. |
| AID561662 | Antimicrobial activity against Pseudomonas aeruginosa isolate OC17355 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Effect of MexXY overexpression on ceftobiprole susceptibility in Pseudomonas aeruginosa. |
| AID496006 | Antimicrobial activity against imipenem resistant Pseudomonas aeruginosa isolates by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vitro potency of CXA-101, a novel cephalosporin, against Pseudomonas aeruginosa displaying various resistance phenotypes, including multidrug resistance. |
| AID372606 | Antibacterial activity against rifampin-resistant Escherichia coli C600 transconjugant producing beta-lactamase of pI 5.2 by microdilution method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | TEM-158 (CMT-9), a new member of the CMT-type extended-spectrum beta-lactamases. |
| AID554430 | Ratio of MIC for Pseudomonas aeruginosa FE60 transformed with pAGH97 carrying mexXY F29S mutant to Pseudomonas aeruginosa PAO1 | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Efflux unbalance in Pseudomonas aeruginosa isolates from cystic fibrosis patients. |
| AID554398 | Antimicrobial activity against Pseudomonas aeruginosa isolate 2804 obtained from cystic fibrosis patient by disk diffusion method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Efflux unbalance in Pseudomonas aeruginosa isolates from cystic fibrosis patients. |
| AID508301 | Inhibition of PBP6 in penicillin-resistant Enterococcus faecium D63r membranes assessed as inhibition of fluorescent ampicillin binding after 20 mins at 37 degC | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2 | Interaction of ceftobiprole with the low-affinity PBP 5 of Enterococcus faecium. |
| AID444057 | Fraction escaping hepatic elimination in human | 2010 | Journal of medicinal chemistry, Feb-11, Volume: 53, Issue:3 | Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. |
| AID522383 | Inhibition of Beta-lactamase KPC-2 in Klebsiella pneumoniae isolates assessed as reduction in antimicrobial MIC of beta-lactams by agar dilution method relative to untreated control | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | In vitro activity of penem-1 in combination with beta-lactams against blaKPC-possessing Klebsiella pneumoniae isolates. |
| AID340735 | Antimicrobial activity against Escherichia coli HB101 harboring pBC-IND-5 plasmid containing metallo-beta-lactamase IND5 assessed as drug level at which microbial resistance was observed by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8 | Identification and characterization of a new metallo-beta-lactamase, IND-5, from a clinical isolate of Chryseobacterium indologenes. |
| AID567580 | Antimicrobial activity against Acinetobacter baumannii assessed as resistant isolate by broth dilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | In vitro antimicrobial activity and mutant prevention concentration of colistin against Acinetobacter baumannii. |
| AID535723 | Ratio of Kcat to Km for Escherichia coli TOP10 beta-lactamase AmpC-A S287N mutant | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Role of the Ser-287-Asn replacement in the hydrolysis spectrum extension of AmpC beta-lactamases in Escherichia coli. |
| AID521426 | Antibacterial activity against Stenotrophomonas maltophilia isolate KJ deficient in L1 beta lactamase gene by Etest | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Induction of L1 and L2 beta-lactamases of Stenotrophomonas maltophilia. |
| AID534879 | Antimicrobial activity against Enterobacter cloacae with nonderepressed AmpC beta-lactamsae by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activity of doripenem, a carbapenem for the treatment of challenging infections caused by gram-negative bacteria, against recent clinical isolates from the United States. |
| AID535903 | Antimicrobial activity against aac(6')-Ib-cr-negative Escherichia coli PU12 harboring GyrA S83L mutant, wild-type GyrB, ParC and qnrS genes by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | High prevalence of plasmid-mediated quinolone resistance genes qnr and aac(6')-Ib-cr in clinical isolates of Enterobacteriaceae from nine teaching hospitals in China. |
| AID567736 | Antimicrobial activity against Pseudomonas aeruginosa OC 12261 by broth macrodilution method | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | Differential selection of single-step AmpC or efflux mutants of Pseudomonas aeruginosa by using cefepime, ceftazidime, or ceftobiprole. |
| AID373767 | Antibacterial activity against imipenem-resistant Acinetobacter baumannii abh17 by broth dilution method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | An OXA-66/OXA-51-like carbapenemase and possibly an efflux pump are associated with resistance to imipenem in Acinetobacter baumannii. |
| AID541504 | Antimicrobial activity against beta-lactamase-producing Haemophilus influenzae clinical isolate after 18 to 22 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Establishment of in vitro susceptibility testing methodologies and comparative activities of piperacillin in combination with the penem {beta}-lactamase inhibitor BLI-489. |
| AID510507 | Antibacterial activity against Acinetobacter calcoaceticus/baumannii complex isolate M3AC9-7 expressing KPC beta lactamase | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Detection of KPC in Acinetobacter spp. in Puerto Rico. |
| AID368310 | Activity of Escherichia coli TEM1 assessed as drug hydrolysis by spectrophotometry relative to cephaloridine | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID556655 | Antimicrobial activity against multidrug resistant Enterobacter aerogenes isolate 10 by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Occurrence of efflux mechanism and cephalosporinase variant in a population of Enterobacter aerogenes and Klebsiella pneumoniae isolates producing extended-spectrum beta-lactamases. |
| AID571045 | Antimicrobial activity against Pseudomonas aeruginosa isolate GB61 obtained from patient with non-cystic fibrosis by Etest | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Role of ampD homologs in overproduction of AmpC in clinical isolates of Pseudomonas aeruginosa. |
| AID519012 | Activity of Beta-lactamase TEM-10 | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | E240V substitution increases catalytic efficiency toward ceftazidime in a new natural TEM-type extended-spectrum beta-lactamase, TEM-149, from Enterobacter aerogenes and Serratia marcescens clinical isolates. |
| AID499124 | Antimicrobial activity against Pseudomonas aeruginosa OC 4354 infected in immunocompromized SKH1 mouse assessed as lesion volume at 25 mg/kg/day, sc measured after 48 hrs postinfection (Rvb = 2195 mm3) | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vivo activity of ceftobiprole in murine skin infections due to Staphylococcus aureus and Pseudomonas aeruginosa. |
| AID528827 | Antimicrobial activity against ESBL producing Klebsiella pneumoniae isolated from ICU patient urine assessed as resistant isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Antimicrobial-resistant pathogens in intensive care units in Canada: results of the Canadian National Intensive Care Unit (CAN-ICU) study, 2005-2006. |
| AID545431 | Antimicrobial activity against Escherichia coli obtained from patient with complicated intra-abdominal infection assessed as percent susceptible isolates by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Susceptibility of gram-negative pathogens isolated from patients with complicated intra-abdominal infections in the United States, 2007-2008: results of the Study for Monitoring Antimicrobial Resistance Trends (SMART). |
| AID510514 | Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 expressing KPC beta lactamase | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Detection of KPC in Acinetobacter spp. in Puerto Rico. |
| AID573400 | Antimicrobial activity against mucA::lox, mutS::lox-deficient Pseudomonas aeruginosa PAOMSAB biofilm harboring nfxB T86C mutant gene selected at 4 ug/ml of azithromycin after 2 passages by Etest method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Azithromycin in Pseudomonas aeruginosa biofilms: bactericidal activity and selection of nfxB mutants. |
| AID279939 | Antibiotic susceptibility by resistance against Pseudomonas aeruginosa from samples collected from patients | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2 | Clinical prediction tool to identify patients with Pseudomonas aeruginosa respiratory tract infections at greatest risk for multidrug resistance. |
| AID499069 | Antimicrobial activity against carbapenem-resistant Enterobacter cloacae NJ91 deficient in CTX-M-14, ompC/F by CLSI method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Phenotypic and genotypic characterization of Enterobacteriaceae with decreased susceptibility to carbapenems: results from large hospital-based surveillance studies in China. |
| AID368524 | Activity of Enterobacter cloacae 4080 AmpC (P99) assessed as drug hydrolysis by spectrophotometry relative to cephaloridine | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID532408 | Antibacterial activity against VIM-2 producing Pseudomonas aeruginosa clone B2 isolate VA-06X-28 by Etest method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | First countrywide survey of acquired metallo-beta-lactamases in gram-negative pathogens in Italy. |
| AID544906 | Antimicrobial activity against Morganella morganii clinical isolate after 18 to 22 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Establishment of in vitro susceptibility testing methodologies and comparative activities of piperacillin in combination with the penem {beta}-lactamase inhibitor BLI-489. |
| AID583024 | Antimicrobial activity against OmpC/OmpF porin deficient Escherichia coli HB4 transformed with Escherichia coli ECB2 plasmid carrying CMY-2 by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Phenotypic and biochemical comparison of the carbapenem-hydrolyzing activities of five plasmid-borne AmpC β-lactamases. |
| AID373753 | Antibacterial activity against imipenem-susceptible Acinetobacter baumannii ab4 by broth dilution method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | An OXA-66/OXA-51-like carbapenemase and possibly an efflux pump are associated with resistance to imipenem in Acinetobacter baumannii. |
| AID301087 | Antibacterial activity against Imipenem resistant Pseudomonas aeruginosa SR-6554 after 20 hrs by agar dilution method | 2007 | Bioorganic & medicinal chemistry, Nov-01, Volume: 15, Issue:21 | A novel series of parenteral cephalosporins exhibiting potent activities against Pseudomonas aeruginosa and other Gram-negative pathogens: synthesis and structure-activity relationships. |
| AID520777 | Antibacterial activity against beta-lactamase KPC-2 producing Klebsiella pneumoniae isolate K10 by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Emergence of Serratia marcescens, Klebsiella pneumoniae, and Escherichia coli Isolates possessing the plasmid-mediated carbapenem-hydrolyzing beta-lactamase KPC-2 in intensive care units of a Chinese hospital. |
| AID524927 | Antimicrobial activity against Escherichia coli MI1443 harboring A77V and D240G mutations in beta lactamase CTX-M-10 by E-test | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Mutational events in cefotaximase extended-spectrum beta-lactamases of the CTX-M-1 cluster involved in ceftazidime resistance. |
| AID368313 | Activity of Staphylococcus aureus betalactamase PC1 assessed as drug hydrolysis by spectrophotometry | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID561663 | Antimicrobial activity against Pseudomonas aeruginosa isolate OC14552 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Effect of MexXY overexpression on ceftobiprole susceptibility in Pseudomonas aeruginosa. |
| AID528971 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus isolated from ICU patient urine assessed as resistant isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Antimicrobial-resistant pathogens in intensive care units in Canada: results of the Canadian National Intensive Care Unit (CAN-ICU) study, 2005-2006. |
| AID368534 | Ratio of Kcat to Km of Morganella morganii AmpC assessed as drug hydrolysis by spectrophotometry relative to cephaloridine | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID544903 | Antimicrobial activity against Serratia marcescens clinical isolate after 18 to 22 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Establishment of in vitro susceptibility testing methodologies and comparative activities of piperacillin in combination with the penem {beta}-lactamase inhibitor BLI-489. |
| AID368307 | Activity of Klebsiella pneumoniae SHV1 assessed as drug hydrolysis by spectrophotometry | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID571040 | Antimicrobial activity against Pseudomonas aeruginosa isolate PA113 obtained from patient with cystic fibrosis by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Role of ampD homologs in overproduction of AmpC in clinical isolates of Pseudomonas aeruginosa. |
| AID373040 | Antimicrobial activity against imipenem and meropenem-resistant Acinetobacter baumannii isolate ZJ58 by CLSI agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Molecular epidemiology of clinical isolates of carbapenem-resistant Acinetobacter spp. from Chinese hospitals. |
| AID498812 | Antimicrobial activity against Escherichia coli ZJ87 expressing KPC-2, TEM-1, ompC by CLSI method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Phenotypic and genotypic characterization of Enterobacteriaceae with decreased susceptibility to carbapenems: results from large hospital-based surveillance studies in China. |
| AID532027 | Antimicrobial activity against Kluyvera georgiana 14751 expressing beta-lactamase CTX-M-78 obtained from bloodstream of patient by disk diffusion method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Novel chromosome-encoded CTX-M-78 beta-lactamase from a Kluyvera georgiana clinical isolate as a putative origin of CTX-M-25 subgroup. |
| AID368485 | Antibacterial activity against Pseudomonas aeruginosa MK-1184 producing beta lactamase AmpC by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID576314 | Antimicrobial activity against ESBL-negative Klebsiella pneumoniae 299332 harboring porin OmpK36 gene by Etest | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | An ertapenem-resistant extended-spectrum-beta-lactamase-producing Klebsiella pneumoniae clone carries a novel OmpK36 porin variant. |
| AID325186 | Antibacterial activity against Staphylococcus aureus Smith by standard serial agar dilution method | 2008 | Bioorganic & medicinal chemistry, Feb-15, Volume: 16, Issue:4 | A novel series of parenteral cephalosporins exhibiting potent activities against both Pseudomonas aeruginosa and other gram-negative pathogens. Part 2: Synthesis and structure-activity relationships. |
| AID532169 | Antimicrobial activity against aac(6')-Ib-cr-positive Citrobacter freundii PU55T harboring wild-type GyrA, ParC, GyrB and qnrA genes by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | High prevalence of plasmid-mediated quinolone resistance genes qnr and aac(6')-Ib-cr in clinical isolates of Enterobacteriaceae from nine teaching hospitals in China. |
| AID532163 | Antimicrobial activity against aac(6')-Ib-cr-negative Escherichia coli PU12T harboring wild-type GyrA, GyrB, ParC and qnrS genes by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | High prevalence of plasmid-mediated quinolone resistance genes qnr and aac(6')-Ib-cr in clinical isolates of Enterobacteriaceae from nine teaching hospitals in China. |
| AID522579 | Antimicrobial activity against AmpC producing Escherichia coli Top10 isolate 8009162 | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Occurrence of ST23 complex phylogroup A Escherichia coli isolates producing extended-spectrum AmpC beta-lactamase in a French hospital. |
| AID522384 | Antimicrobial activity against Aeromonas enteropelogenes ATCC 49803 producing endogenous class C beta-lactamase TRU-1 | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Genetic and biochemical characterization of TRU-1, the endogenous class C beta-lactamase from Aeromonas enteropelogenes. |
| AID373764 | Antibacterial activity against imipenem-resistant Acinetobacter baumannii abh11 by broth dilution method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | An OXA-66/OXA-51-like carbapenemase and possibly an efflux pump are associated with resistance to imipenem in Acinetobacter baumannii. |
| AID567748 | Antimicrobial activity against Pseudomonas aeruginosa OC 11678 expressing 27 fold elevated mexX expression and 16 fold elevated mexY expression by broth macrodilution method | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | Differential selection of single-step AmpC or efflux mutants of Pseudomonas aeruginosa by using cefepime, ceftazidime, or ceftobiprole. |
| AID559688 | Antibacterial activity against ESBL-positive and OmpF and OmpC porin-deficient Escherichia coli HB4 | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | GES-11, a novel integron-associated GES variant in Acinetobacter baumannii. |
| AID528966 | Antimicrobial activity against methicillin-susceptible Staphylococcus epidermidis isolated from ICU patient urine assessed as resistant isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Antimicrobial-resistant pathogens in intensive care units in Canada: results of the Canadian National Intensive Care Unit (CAN-ICU) study, 2005-2006. |
| AID554389 | Antimicrobial activity against ampicillin- and ticarcillin-resistant Pseudomonas aeruginosa FE60 mutant transformed with pAGH97 carrying mexXY F1018L mutant by twofold macrodilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Efflux unbalance in Pseudomonas aeruginosa isolates from cystic fibrosis patients. |
| AID535755 | Antimicrobial activity against community-acquired Escherichia coli obtained from patient with intra-abdominal infection assessed as susceptible isolates by EUCAST method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Incidence and antimicrobial susceptibility of Escherichia coli and Klebsiella pneumoniae with extended-spectrum beta-lactamases in community- and hospital-associated intra-abdominal infections in Europe: results of the 2008 Study for Monitoring Antimicrob |
| AID561669 | Antimicrobial activity against Pseudomonas aeruginosa isolate OC16827 harboring plasmid MexXY expressing mexXY gene by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Effect of MexXY overexpression on ceftobiprole susceptibility in Pseudomonas aeruginosa. |
| AID498845 | Antimicrobial activity against carbapenem-resistant Klebsiella pneumoniae PU105 deficient TEM-1, SHV-12, CTX-M-14, DHA-1, qnrB10/B4-like, aac(6')-Ib-cr, ompK35/36 by CLSI method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Phenotypic and genotypic characterization of Enterobacteriaceae with decreased susceptibility to carbapenems: results from large hospital-based surveillance studies in China. |
| AID519186 | Antimicrobial activity against MexXY-OprM-overproducing Pseudomonas aeruginosa PAO1 harboring MexY and MexZ mutant gene selected after 4 ug/ml of cefepime exposure | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Relationship between antibiotic use and incidence of MexXY-OprM overproducers among clinical isolates of Pseudomonas aeruginosa. |
| AID587612 | Antimicrobial activity against carbapenemases KPC-producing Klebsiella pneumoniae VA-406 infected in sc dosed CD-1 mouse | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1 | Evaluation of ceftazidime and NXL104 in two murine models of infection due to KPC-producing Klebsiella pneumoniae. |
| AID535637 | Antimicrobial activity against Group B streptococcus serotype Ib R3 harboring Q557E, A400V mutations in PBP 2X and T567I, G539E mutations in PBP 2B by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | Genetic heterogeneity in pbp genes among clinically isolated group B Streptococci with reduced penicillin susceptibility. |
| AID508726 | Antibacterial activity against carbapenem-resistant Pseudomonas aeruginosa isolate 1B2 RCA2 harboring acquired beta-lactamase PER-1 by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2 | Activity of a new antipseudomonal cephalosporin, CXA-101 (FR264205), against carbapenem-resistant and multidrug-resistant Pseudomonas aeruginosa clinical strains. |
| AID542065 | Antibacterial activity against Klebsiella pneumoniae A expressing CTX-M group 1 beta-lactamase by Etest method | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Nationwide survey of CTX-M-type extended-spectrum beta-lactamases among Klebsiella pneumoniae isolates in Slovenian hospitals. |
| AID558792 | Antimicrobial activity against extended spectrum beta-lactamase-expressing Klebsiella pneumoniae assessed as percent susceptible isolates by CLSI method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Emergence of high levels of extended-spectrum-beta-lactamase-producing gram-negative bacilli in the Asia-Pacific region: data from the Study for Monitoring Antimicrobial Resistance Trends (SMART) program, 2007. |
| AID560113 | Antibacterial activity against Escherichia coli TOP10 harboring recombinant plasmid RTG4-S69-V49 by Etest method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Genetic and biochemical characterization of the first extended-spectrum CARB-type beta-lactamase, RTG-4, from Acinetobacter baumannii. |
| AID285666 | Antimicrobial activity against Pseudomonas aeruginosa 22E3 tracheal isolates from mechanically ventilated chronic respiratory insufficiency patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID508298 | Inhibition of PBP4 in penicillin-resistant Enterococcus faecium D63r membranes assessed as inhibition of fluorescent ampicillin binding after 20 mins at 37 degC | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2 | Interaction of ceftobiprole with the low-affinity PBP 5 of Enterococcus faecium. |
| AID555219 | Antibacterial activity against Escherichia coli DH5alpha carrying ampC gene of Acinetobacter genomosp. 3 isolate 69 by Etest method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Genetic variability among ampC genes from acinetobacter genomic species 3. |
| AID558051 | Antimicrobial activity against blaKPC-positive Klebsiella pneumoniae S14 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Genetic organization of transposase regions surrounding blaKPC carbapenemase genes on plasmids from Klebsiella strains isolated in a New York City hospital. |
| AID324868 | Antimicrobial activity against Acinetobacter baumannii B46 by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Tigecycline Efflux as a Mechanism for Nonsusceptibility in Acinetobacter baumannii. |
| AID534603 | Antimicrobial activity against Ceftazidime non-susceptible Enterobacteriaceae by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activity of doripenem, a carbapenem for the treatment of challenging infections caused by gram-negative bacteria, against recent clinical isolates from the United States. |
| AID522582 | Antimicrobial activity against Escherichia coli Top10 | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Occurrence of ST23 complex phylogroup A Escherichia coli isolates producing extended-spectrum AmpC beta-lactamase in a French hospital. |
| AID557203 | Toxicity in critically ill patient with ventilator-associated pneumoniae assessed as adverse effects at 2 g/kg administered as 3 hr infusion every 8 hrs by HPLC | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Population pharmacokinetics of high-dose, prolonged-infusion cefepime in adult critically ill patients with ventilator-associated pneumonia. |
| AID295843 | Antimicrobial activity against Proteus vulgaris A161 by disk diffusion method at 300 ug/disc | 2007 | European journal of medicinal chemistry, Jul, Volume: 42, Issue:7 | Synthesis of some novel heterocyclic compounds derived from diflunisal hydrazide as potential anti-infective and anti-inflammatory agents. |
| AID561442 | Antibacterial activity against Escherichia coli YD006 harboring beta-lactamase CMY-33 gene by Etest method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Reduced susceptibility to cefepime among Escherichia coli clinical isolates producing novel variants of CMY-2 beta-lactamase. |
| AID563977 | Ratio of Kcat to Km for Klebsiella pneumoniae 05-560 beta-lactamase VIM2 | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Characterization of a new metallo-beta-lactamase gene, bla(NDM-1), and a novel erythromycin esterase gene carried on a unique genetic structure in Klebsiella pneumoniae sequence type 14 from India. |
| AID394487 | Activity of Escherichia coli beta-lactamase ACC4 by UV spectrophotometry | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10 | Plasmid-encoded ACC-4, an extended-spectrum cephalosporinase variant from Escherichia coli. |
| AID532399 | Antibacterial activity against VIM-1 producing Pseudomonas aeruginosa clone D2 isolate VA-06X-16 by Etest method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | First countrywide survey of acquired metallo-beta-lactamases in gram-negative pathogens in Italy. |
| AID549332 | Antimicrobial activity against Escherichia coli isolate 86 harboring bla CTX-M-3a gene by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | blaCTX-M genes in escherichia coli strains from Croatian Hospitals are located in new (blaCTX-M-3a) and widely spread (blaCTX-M-3a and blaCTX-M-15) genetic structures. |
| AID573212 | Antimicrobial activity against mucA::lox, mutS::lox-deficient Pseudomonas aeruginosa PAOMSAB biofilm harboring nfxB C25T mutant gene selected at 1 ug/ml of azithromycin after 2 passages by Etest method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Azithromycin in Pseudomonas aeruginosa biofilms: bactericidal activity and selection of nfxB mutants. |
| AID532405 | Antibacterial activity against VIM-1 producing Pseudomonas aeruginosa clone G isolate NA-14X-13 by Etest method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | First countrywide survey of acquired metallo-beta-lactamases in gram-negative pathogens in Italy. |
| AID625286 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for hepatitis | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID547528 | Antimicrobial activity against Streptococcus intermedius obtained from patient with cystic fibrosis assessed as non-susceptible isolates grown on mueller-Hinton blood agar at 30 ug/ml after 24 hrs at 37 degC by disk diffusion method in presence of 5% defr | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Macrolide and clindamycin resistance in Streptococcus milleri group isolates from the airways of cystic fibrosis patients. |
| AID564222 | Antimicrobial activity against Escherichia coli TOP10 harboring plasmid PH1 by Etest method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | OXA-143, a novel carbapenem-hydrolyzing class D beta-lactamase in Acinetobacter baumannii. |
| AID340729 | Antimicrobial activity against Enterobacter isolates producing extended-spectrum beta-lactamase CTX-M-14 by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8 | Extended-spectrum beta-lactamases of the CTX-M type now in Switzerland. |
| AID555199 | Antimicrobial activity against Pseudomonas aeruginosa PAO1 harboring deltaampD::lox deltaampDh2::lox delta ampDh3::lox after 18 hrs by Etest | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Inactivation of the glycoside hydrolase NagZ attenuates antipseudomonal beta-lactam resistance in Pseudomonas aeruginosa. |
| AID522014 | Antimicrobial activity against Escherichia coli isolate J53 harboring pBEL containing beta-lactamase OXA-48 located within transposon Tn1999.2 by Etest method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Spread of OXA-48-encoding plasmid in Turkey and beyond. |
| AID394490 | Ratio of Vmax to Km for Hafnia alvei beta-lactamase ACC-1 | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10 | Plasmid-encoded ACC-4, an extended-spectrum cephalosporinase variant from Escherichia coli. |
| AID573403 | Antimicrobial activity against mucA::lox, mutS::lox-deficient Pseudomonas aeruginosa PAOMSAB biofilm harboring nfxB C89T mutant gene selected at 4 ug/ml of azithromycin after 6 passages by Etest method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Azithromycin in Pseudomonas aeruginosa biofilms: bactericidal activity and selection of nfxB mutants. |
| AID574431 | Antimicrobial activity against Escherichia coli isolate 540 expressing beta-lactamase KPC2, TEM and PFGE cluster 4 isolated from synovial fluid of patient by vitek-2 method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Carbapenem-resistant KPC-2-producing Escherichia coli in a Tel Aviv Medical Center, 2005 to 2008. |
| AID522571 | Antimicrobial activity against Escherichia coli isolate 7010738 with AmpC beta-lactamase H296P mutation | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Occurrence of ST23 complex phylogroup A Escherichia coli isolates producing extended-spectrum AmpC beta-lactamase in a French hospital. |
| AID499062 | Antimicrobial activity against carbapenem-resistant Escherichia coli HX74 deficient in TEM-1, CTX-M-14, CTX-M-3, aac(6')-Ibcr, ompC/F by CLSI method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Phenotypic and genotypic characterization of Enterobacteriaceae with decreased susceptibility to carbapenems: results from large hospital-based surveillance studies in China. |
| AID519008 | Activity of Beta-lactamase TEM-149 expressed in Escherichia coli HB101 | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | E240V substitution increases catalytic efficiency toward ceftazidime in a new natural TEM-type extended-spectrum beta-lactamase, TEM-149, from Enterobacter aerogenes and Serratia marcescens clinical isolates. |
| AID530325 | Antimicrobial activity against Pseudomonas aeruginosa PAO1 by Etest method | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Characterization of the new metallo-beta-lactamase VIM-13 and its integron-borne gene from a Pseudomonas aeruginosa clinical isolate in Spain. |
| AID324854 | Antimicrobial activity against Acinetobacter baumannii A24 by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Tigecycline Efflux as a Mechanism for Nonsusceptibility in Acinetobacter baumannii. |
| AID521283 | Antimicrobial activity against CTX-M-59 and TEM-1 producing Klebsiella pneumoniae transconjugants/transformants with PFGE pulsotype G by Etest | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Multiclonal outbreak of Klebsiella pneumoniae producing extended-spectrum beta-lactamase CTX-M-2 and novel variant CTX-M-59 in a neonatal intensive care unit in Brazil. |
| AID368499 | Ratio of Kcat to Km of Klebsiella oxytoca beta-lactamase K1 assessed as drug hydrolysis by spectrophotometry | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID571904 | Antimicrobial activity against ISAba1 linked with the blaOXA-51-type beta-lactamase harboring Acinetobacter baumannii beta clonal group isolate 16 expressing ompA, adeB, adeM, aacA4, blaSHV-5 by Etest method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Correlation of antimicrobial resistance with beta-lactamases, the OmpA-like porin, and efflux pumps in clinical isolates of Acinetobacter baumannii endemic to New York City. |
| AID559683 | Antibacterial activity against Acinetobacter baumannii BM4674 isolated from the tibia fracture of a patient by Etest method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | GES-11, a novel integron-associated GES variant in Acinetobacter baumannii. |
| AID574437 | Antimicrobial activity against Escherichia coli isolate 1679 expressing beta-lactamase KPC2, SHV-12, TEM and PFGE cluster 6 isolated from peritoneal fluid of patient by vitek-2 method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Carbapenem-resistant KPC-2-producing Escherichia coli in a Tel Aviv Medical Center, 2005 to 2008. |
| AID1706287 | Elimination half life in human at 2 g, iv measured after 0.5 to 8 hrs by high-pressure liquid chromatography method | 2020 | European journal of medicinal chemistry, Dec-15, Volume: 208 | β-lactam antibiotics: An overview from a medicinal chemistry perspective. |
| AID559920 | Antibacterial activity against Escherichia coli TOP10 harboring recombinant plasmid RTG4-S69 by Etest method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Genetic and biochemical characterization of the first extended-spectrum CARB-type beta-lactamase, RTG-4, from Acinetobacter baumannii. |
| AID511581 | Antimicrobial activity against beta-lactam resistant Pseudomonas aeruginosa PAO1 deficient in ampD and dacB gene selected in vitro after antipseudomonal treatment of intensive care unit patient by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Activity of a new cephalosporin, CXA-101 (FR264205), against beta-lactam-resistant Pseudomonas aeruginosa mutants selected in vitro and after antipseudomonal treatment of intensive care unit patients. |
| AID535142 | Antimicrobial activity against imipenem susceptible Pseudomonas aeruginosa assessed as resistant isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activity of doripenem, a carbapenem for the treatment of challenging infections caused by gram-negative bacteria, against recent clinical isolates from the United States. |
| AID544957 | Antimicrobial activity against Escherichia coli expressing beta-lactamase SHV by Etest | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Characterization and sequence analysis of extended-spectrum-{beta}-lactamase-encoding genes from Escherichia coli, Klebsiella pneumoniae, and Proteus mirabilis isolates collected during tigecycline phase 3 clinical trials. |
| AID554986 | Antibacterial activity against Acinetobacter genomosp. 3 isolate 21 by Etest method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Genetic variability among ampC genes from acinetobacter genomic species 3. |
| AID565516 | Antibacterial activity against mexB, mexY and mexD expressing Pseudomonas aeruginosa isolate Paebeta-19 harboring A residue at 105 position in PDC- 3 wild-type OprD porin gene by Etest method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Molecular epidemiology and mechanisms of carbapenem resistance in Pseudomonas aeruginosa. |
| AID368504 | Ratio of Kcat to Km of Klebsiella pneumoniae TEM26 assessed as drug hydrolysis by spectrophotometry relative to cephaloridine | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID495915 | Ratio of Kcat to Km for beta-lactamase VIM-1 expressed in Escherichia coli TOP10 by spectrophotometry | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | VIM-19, a metallo-beta-lactamase with increased carbapenemase activity from Escherichia coli and Klebsiella pneumoniae. |
| AID542060 | Antibacterial activity against Klebsiella pneumoniae expressing CTX-M group 1 beta-lactamase by Etest method | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Nationwide survey of CTX-M-type extended-spectrum beta-lactamases among Klebsiella pneumoniae isolates in Slovenian hospitals. |
| AID761247 | Antibacterial activity against Pseudomonas aeruginosa from cystic fibrosis patients by broth microdilution method | 2013 | Journal of medicinal chemistry, Jul-11, Volume: 56, Issue:13 | Pyridone-conjugated monobactam antibiotics with gram-negative activity. |
| AID523888 | Antimicrobial activity against Acinetobacter baumannii 6AB11 harboring ISAba1-blaOXA-66 gene by Etest | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Genetic basis of multidrug resistance in Acinetobacter clinical isolates in Taiwan. |
| AID518465 | Antimicrobial activity against Pseudomonas aeruginosa 527 assessed as number of passages required for MIC to rise above 4 times original MIC | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli. |
| AID510510 | Antibacterial activity against Acinetobacter calcoaceticus/baumannii complex isolate N2AC9-18 expressing KPC beta lactamase | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Detection of KPC in Acinetobacter spp. in Puerto Rico. |
| AID405825 | Antimicrobial activity against Acinetobacter baumannii 694 isolate harboring bla IMP-1 carrying integron In86 containing aminoglycoside resistance gene aac(6')-3 | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | Characterization of an integron carrying blaIMP-1 and a new aminoglycoside resistance gene, aac(6')-31, and its dissemination among genetically unrelated clinical isolates in a Brazilian hospital. |
| AID519181 | Antimicrobial activity against MexXY-OprM-overproducing Pseudomonas aeruginosa PAO1 harboring MexY agrZ mutant and MexZ mutant gene selected after 1 ug/ml of Norfloxacin exposure | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Relationship between antibiotic use and incidence of MexXY-OprM overproducers among clinical isolates of Pseudomonas aeruginosa. |
| AID555193 | Antimicrobial activity against Pseudomonas aeruginosa PAO1 harboring deltaampD::lox deltaampDh2::lox deltaampDh3::lox deltanagZ::Gm after 18 hrs by Etest | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Inactivation of the glycoside hydrolase NagZ attenuates antipseudomonal beta-lactam resistance in Pseudomonas aeruginosa. |
| AID572126 | Antimicrobial activity against ISAba1 linked with the blaOXA-51-type beta-lactamase harboring Acinetobacter baumannii lambda clonal group isolate 30 expressing ampC, ompA, adeB, adeM, aadB, aadA1 by Etest method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Correlation of antimicrobial resistance with beta-lactamases, the OmpA-like porin, and efflux pumps in clinical isolates of Acinetobacter baumannii endemic to New York City. |
| AID424856 | Antibacterial activity in Serratia sp. infected patient assessed as mortality after 28 days | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Failure of current cefepime breakpoints to predict clinical outcomes of bacteremia caused by gram-negative organisms. |
| AID285610 | Antimicrobial activity against Pseudomonas aeruginosa 65.68-2 tracheal isolates from mechanically ventilated tuberculosis patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID444054 | Oral bioavailability in human | 2010 | Journal of medicinal chemistry, Feb-11, Volume: 53, Issue:3 | Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. |
| AID543415 | Antimicrobial activity against rifampicin-resistant Escherichia coli X1037 transconjugant by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Novel chimeric beta-lactamase CTX-M-64, a hybrid of CTX-M-15-like and CTX-M-14 beta-lactamases, found in a Shigella sonnei strain resistant to various oxyimino-cephalosporins, including ceftazidime. |
| AID522386 | Antimicrobial activity against Escherichia coli NI540 carrying cloned class C beta-lactamase TRU-1 gene | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Genetic and biochemical characterization of TRU-1, the endogenous class C beta-lactamase from Aeromonas enteropelogenes. |
| AID563975 | Ratio of Kcat to Km for Klebsiella pneumoniae 05-560 beta-lactamase IMP1 | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Characterization of a new metallo-beta-lactamase gene, bla(NDM-1), and a novel erythromycin esterase gene carried on a unique genetic structure in Klebsiella pneumoniae sequence type 14 from India. |
| AID499156 | fAUC (0-infinity) in immunocompromized SKH1 mouse plasma at 50 mg/kg, sc | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vivo activity of ceftobiprole in murine skin infections due to Staphylococcus aureus and Pseudomonas aeruginosa. |
| AID567747 | Antimicrobial activity against Pseudomonas aeruginosa OC 11678 expressing 9 fold elevated AmpC expression by broth macrodilution method | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | Differential selection of single-step AmpC or efflux mutants of Pseudomonas aeruginosa by using cefepime, ceftazidime, or ceftobiprole. |
| AID368729 | Activity of Pseudomonas aeruginosa AmpC assessed as drug hydrolysis by spectrophotometry | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID521997 | Antimicrobial activity against Klebsiella pneumoniae isolate Kp4A expressing beta-lactamase OXA-48 and CTX-M-15 by Etest method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Spread of OXA-48-encoding plasmid in Turkey and beyond. |
| AID573213 | Antimicrobial activity against mucA::lox, mutS::lox-deficient Pseudomonas aeruginosa PAOMSAB biofilm harboring nfxB T544C mutant gene selected at 4 ug/ml of azithromycin after 1 passages by Etest method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Azithromycin in Pseudomonas aeruginosa biofilms: bactericidal activity and selection of nfxB mutants. |
| AID546432 | Ratio of Kcat to Km for Pseudomonas aeruginosa PDC-3 by spectrophotometer | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Extended-spectrum cephalosporinases in Pseudomonas aeruginosa. |
| AID571935 | Antimicrobial activity against Escherichia coli MC4100 harboring promoter hybrid 2 in beta-lactamase GES-1 by Etest | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Relative strengths of the class 1 integron promoter hybrid 2 and the combinations of strong and hybrid 1 with an active p2 promoter. |
| AID560074 | Antimicrobial activity against Enterobacter cloacae isolate 5420 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | In vitro activity of ceftaroline alone and in combination against clinical isolates of resistant gram-negative pathogens, including beta-lactamase-producing Enterobacteriaceae and Pseudomonas aeruginosa. |
| AID520795 | Antimicrobial activity against CTX-M-59 producing Klebsiella pneumoniae with PFGE pulsotype C by Etest | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Multiclonal outbreak of Klebsiella pneumoniae producing extended-spectrum beta-lactamase CTX-M-2 and novel variant CTX-M-59 in a neonatal intensive care unit in Brazil. |
| AID373766 | Antibacterial activity against imipenem-resistant Acinetobacter baumannii abh14 by broth dilution method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | An OXA-66/OXA-51-like carbapenemase and possibly an efflux pump are associated with resistance to imipenem in Acinetobacter baumannii. |
| AID285625 | Antimicrobial activity against Pseudomonas aeruginosa 9A1 tracheal isolates from mechanically ventilated chronic respiratory insufficiency patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID558047 | Antimicrobial activity against blaKPC-positive Klebsiella pneumoniae S10 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Genetic organization of transposase regions surrounding blaKPC carbapenemase genes on plasmids from Klebsiella strains isolated in a New York City hospital. |
| AID528832 | Antimicrobial activity against CTX-M ESBL producing Escherichia coli isolated from ICU patient urine assessed as resistant isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Antimicrobial-resistant pathogens in intensive care units in Canada: results of the Canadian National Intensive Care Unit (CAN-ICU) study, 2005-2006. |
| AID564454 | Antimicrobial activity against Pseudomonas aeruginosa isolate 1060 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | In vivo efficacy of 1- and 2-gram human simulated prolonged infusions of doripenem against Pseudomonas aeruginosa. |
| AID495840 | Hydrolytic activity of beta-lactamase VIM-1 in Escherichia coli DH5alpha expressing pBCLL/39H by microacidimetric method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Novel VIM metallo-beta-lactamase variant from clinical isolates of Enterobacteriaceae from Algeria. |
| AID528821 | Antimicrobial activity against carbapenem-resistant Pseudomonas aeruginosa isolated from ICU patient wound assessed as resistant isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Antimicrobial-resistant pathogens in intensive care units in Canada: results of the Canadian National Intensive Care Unit (CAN-ICU) study, 2005-2006. |
| AID567304 | Antimicrobial activity against SHV-12 ESBL producing Pseudomonas aeruginosa isolate 2202 isolated from burn patient by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Acquisition of a transposon encoding extended-spectrum beta-lactamase SHV-12 by Pseudomonas aeruginosa isolates during the clinical course of a burn patient. |
| AID285597 | Antimicrobial activity against Pseudomonas aeruginosa 2A1 tracheal isolates from mechanically ventilated tuberculosis patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID531590 | Antibacterial activity against Providencia stuartii obtained from complicated skin and skin structure infections by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro activity of ceftobiprole against pathogens from two phase 3 clinical trials of complicated skin and skin structure infections. |
| AID532416 | Antibacterial activity against IMP-13 producing Pseudomonas aeruginosa clone C2 isolate NA-14X-11 by Etest method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | First countrywide survey of acquired metallo-beta-lactamases in gram-negative pathogens in Italy. |
| AID285605 | Antimicrobial activity against Pseudomonas aeruginosa 2F6 tracheal isolates from mechanically ventilated tuberculosis patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID495634 | Antimicrobial activity against Escherichia coli DH10B by Etest method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Molecular and biochemical characterization of the natural chromosome-encoded class A beta-lactamase from Pseudomonas luteola. |
| AID285680 | Antimicrobial activity against Pseudomonas aeruginosa 29G8 tracheal isolates from mechanically ventilated chronic respiratory insufficiency patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID499071 | Antimicrobial activity against Klebsiella pneumoniae WH97 expressing SHV-33, aac(6')-Ib, ompK35 DE by CLSI method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Phenotypic and genotypic characterization of Enterobacteriaceae with decreased susceptibility to carbapenems: results from large hospital-based surveillance studies in China. |
| AID574428 | Antimicrobial activity against Escherichia coli isolate 360T expressing beta-lactamase KPC2, OXA-9 and PFGE cluster 1 isolated from urine of patient by vitek-2 method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Carbapenem-resistant KPC-2-producing Escherichia coli in a Tel Aviv Medical Center, 2005 to 2008. |
| AID394694 | Antibacterial activity against beta-lactams resistant Pseudomonas aeruginosa isolate expressing MexAB-OprM pump, MexXY-OprM pump by macrodilution technique | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10 | Pseudomonas aeruginosa may accumulate drug resistance mechanisms without losing its ability to cause bloodstream infections. |
| AID1318926 | Antibacterial activity against Pseudomonas aeruginosa PAO1 | 2016 | Journal of medicinal chemistry, 09-22, Volume: 59, Issue:18 | Hybrid Antibiotic Overcomes Resistance in P. aeruginosa by Enhancing Outer Membrane Penetration and Reducing Efflux. |
| AID554436 | Ratio of MIC for Pseudomonas aeruginosa 2721 to MIC for Pseudomonas aeruginosa PAO1 | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Efflux unbalance in Pseudomonas aeruginosa isolates from cystic fibrosis patients. |
| AID324874 | Antimicrobial activity against Acinetobacter baumannii C75 in presence of efflux pump inhibitor phenyl-arginine-beta-naphthylamide by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Tigecycline Efflux as a Mechanism for Nonsusceptibility in Acinetobacter baumannii. |
| AID373031 | Antimicrobial activity against imipenem and meropenem-resistant Acinetobacter baumannii isolate PU4A22 by CLSI agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Molecular epidemiology of clinical isolates of carbapenem-resistant Acinetobacter spp. from Chinese hospitals. |
| AID564213 | Antimicrobial activity against Acinetobacter baumannii ATCC 135040 by Etest method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | OXA-143, a novel carbapenem-hydrolyzing class D beta-lactamase in Acinetobacter baumannii. |
| AID498819 | Antimicrobial activity against Klebsiella pneumoniae GZ64T expressing IMP-4 by CLSI method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Phenotypic and genotypic characterization of Enterobacteriaceae with decreased susceptibility to carbapenems: results from large hospital-based surveillance studies in China. |
| AID518520 | Antimicrobial activity against Escherichia coli TOP10(pNOR-1) expressing CSP-1 gene after 2 days by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Characterization of CSP-1, a novel extended-spectrum beta-lactamase produced by a clinical isolate of Capnocytophaga sputigena. |
| AID535885 | Antimicrobial activity against aac(6')-Ib-cr-positive Klebsiella pneumoniae JN41 harboring GyrA S83I, ParC S80I mutant, wild-type GyrB and qnrB genes by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | High prevalence of plasmid-mediated quinolone resistance genes qnr and aac(6')-Ib-cr in clinical isolates of Enterobacteriaceae from nine teaching hospitals in China. |
| AID562339 | Ratio of Kcat to Km for Chryseobacterium indologenes 597 metallo-beta-lactamase IND-5 expressed in Escherichia coli DH5alpha by Michaelis-Menten equation | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | IND-6, a highly divergent IND-type metallo-beta-lactamase from Chryseobacterium indologenes strain 597 isolated in Burkina Faso. |
| AID542059 | Antibacterial activity against Klebsiella pneumoniae B expressing CTX-M group 1 beta-lactamase by Etest method in presence of clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Nationwide survey of CTX-M-type extended-spectrum beta-lactamases among Klebsiella pneumoniae isolates in Slovenian hospitals. |
| AID428269 | Antimicrobial activity against Klebsiella sp. by CLSI broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | Antimicrobial activities of tigecycline and other broad-spectrum antimicrobials tested against serine carbapenemase- and metallo-beta-lactamase-producing Enterobacteriaceae: report from the SENTRY Antimicrobial Surveillance Program. |
| AID532415 | Antibacterial activity against IMP-13 producing Pseudomonas aeruginosa clone C2 isolate NA-14X-10 by Etest method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | First countrywide survey of acquired metallo-beta-lactamases in gram-negative pathogens in Italy. |
| AID541507 | Antimicrobial activity against beta-lactamase-negative Haemophilus influenzae clinical isolate after 18 to 22 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Establishment of in vitro susceptibility testing methodologies and comparative activities of piperacillin in combination with the penem {beta}-lactamase inhibitor BLI-489. |
| AID534084 | Antibacterial activity against erythromycin-resistant Streptococcus pneumoniae isolate by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | In vitro activity of ceftaroline against Streptococcus pneumoniae isolates exhibiting resistance to penicillin, amoxicillin, and cefotaxime. |
| AID565766 | Antimicrobial activity against Pseudomonas aeruginosa OC 12070 expressing 7 fold elevated AmpC expression by broth macrodilution method | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | Differential selection of single-step AmpC or efflux mutants of Pseudomonas aeruginosa by using cefepime, ceftazidime, or ceftobiprole. |
| AID520715 | Antibacterial activity against Acinetobacter baumannii CIP7010 by disk diffusion method | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Carbapenem-resistant Acinetobacter baumannii isolates from Tunisia producing the OXA-58-like carbapenem-hydrolyzing oxacillinase OXA-97. |
| AID1225766 | Antibacterial activity against Klebsiella pneumoniae KP1005 expressing CTX-M-14 by broth microdilution method | 2015 | Journal of medicinal chemistry, May-14, Volume: 58, Issue:9 | Discovery of a Cyclic Boronic Acid β-Lactamase Inhibitor (RPX7009) with Utility vs Class A Serine Carbapenemases. |
| AID322317 | Antibacterial activity against CTX-M group 9 enzyme producing Escherichia coli isolates assessed as percent resistant isolates by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Spread of extended-spectrum beta-lactamase CTX-M-producing escherichia coli clinical isolates in community and nosocomial environments in Portugal. |
| AID283546 | Antibacterial activity against Pseudomonas aeruginosa KJ7106 with inactivated PA5471 gene by microdilution method | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3 | Cumulative effects of several nonenzymatic mechanisms on the resistance of Pseudomonas aeruginosa to aminoglycosides. |
| AID573190 | Antimicrobial activity against nfxB gene-deficient Pseudomonas aeruginosa PAONB biofilm by Etest method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Azithromycin in Pseudomonas aeruginosa biofilms: bactericidal activity and selection of nfxB mutants. |
| AID325187 | Antibacterial activity against penicillin-resistant Streptococcus pneumoniae SR-16675 by standard serial agar dilution method | 2008 | Bioorganic & medicinal chemistry, Feb-15, Volume: 16, Issue:4 | A novel series of parenteral cephalosporins exhibiting potent activities against both Pseudomonas aeruginosa and other gram-negative pathogens. Part 2: Synthesis and structure-activity relationships. |
| AID1361173 | Antimicrobial activity against KPC-2 producing Klebsiella pneumoniae ATCC BAA-1705 in presence of human apo-transferrin by broth microdilution method | 2018 | European journal of medicinal chemistry, Jul-15, Volume: 155 | Cefiderocol (S-649266), A new siderophore cephalosporin exhibiting potent activities against Pseudomonas aeruginosa and other gram-negative pathogens including multi-drug resistant bacteria: Structure activity relationship. |
| AID522393 | Ratio of Kcat Km for Aeromonas caviae Beta-lactamase CAV1 | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Genetic and biochemical characterization of TRU-1, the endogenous class C beta-lactamase from Aeromonas enteropelogenes. |
| AID573401 | Antimicrobial activity against mucA::lox, mutS::lox-deficient Pseudomonas aeruginosa PAOMSAA biofilm harboring nfxB T77C mutant gene selected at 4 ug/ml of azithromycin after 3 passages by Etest method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Azithromycin in Pseudomonas aeruginosa biofilms: bactericidal activity and selection of nfxB mutants. |
| AID324362 | Ratio of kcat to Km for Acinetobacter johnsonii SCO1 | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Identification of the novel narrow-spectrum beta-lactamase SCO-1 in Acinetobacter spp. from Argentina. |
| AID324359 | Antibacterial activity against Escherichia coli DH10B by agar dilution technique | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Identification of the novel narrow-spectrum beta-lactamase SCO-1 in Acinetobacter spp. from Argentina. |
| AID546423 | Antimicrobial activity against Pseudomonas aeruginosa 12B harboring recombinant pBB-PDC-3 by Etest | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Extended-spectrum cephalosporinases in Pseudomonas aeruginosa. |
| AID660263 | Ratio of MIC for wild type Salmonella typhimurium SH5014 to MIC for Salmonella typhimurium SH7616 harboring missense mutation in acrA/acrB gene by two-fold serial dilution method | 2012 | European journal of medicinal chemistry, Jun, Volume: 52 | Computational analysis of structure-based interactions and ligand properties can predict efflux effects on antibiotics. |
| AID428268 | Antimicrobial activity against carbapenemase producing Enterobacteriaceae assessed as resistant isolates by CLSI breakpoint assay | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | Antimicrobial activities of tigecycline and other broad-spectrum antimicrobials tested against serine carbapenemase- and metallo-beta-lactamase-producing Enterobacteriaceae: report from the SENTRY Antimicrobial Surveillance Program. |
| AID285626 | Antimicrobial activity against Pseudomonas aeruginosa 9A3 tracheal isolates from mechanically ventilated chronic respiratory insufficiency patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID532205 | Antimicrobial activity against aac(6')-Ib-cr-positive Klebsiella pneumoniae WH99T harboring qnrB gene by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | High prevalence of plasmid-mediated quinolone resistance genes qnr and aac(6')-Ib-cr in clinical isolates of Enterobacteriaceae from nine teaching hospitals in China. |
| AID559267 | Antimicrobial activity against rifampin-resistant Escherichia coli J53 transconjugated with Proteus vulgaris Pv9 expressing beta-lactamase PER-1 by disk diffusion method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Emergence of extended-spectrum beta-lactamase PER-1 in Proteus vulgaris and Providencia stuartii isolates from Algiers, Algeria. |
| AID1373320 | Antimicrobial activity against Escherichia coli expressing beta-lactamase Oxa-51 by CLSI broth microdilution method | 2018 | Bioorganic & medicinal chemistry letters, 02-15, Volume: 28, Issue:4 | Optimization of novel monobactams with activity against carbapenem-resistant Enterobacteriaceae - Identification of LYS228. |
| AID405634 | Inhibition of bocillin FL binding to Pseudomonas aeruginosa PAO1 penicillin-binding protein 1a | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | Binding of ceftobiprole and comparators to the penicillin-binding proteins of Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Streptococcus pneumoniae. |
| AID524929 | Antimicrobial activity against Escherichia coli MI1443 harboring N106S and P167S mutations in beta lactamase CTX-M-10 by E-test | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Mutational events in cefotaximase extended-spectrum beta-lactamases of the CTX-M-1 cluster involved in ceftazidime resistance. |
| AID562474 | Antimicrobial activity against rifampicin-resistant Escherichia coli A15 transconjugant expressing beta-lactamase SHV-12 by Etest | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | Emergence of Klebsiella pneumoniae ST258 with KPC-2 in Poland. |
| AID372612 | Antibacterial activity against rifampin-resistant Escherichia coli C600 by microdilution method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | TEM-158 (CMT-9), a new member of the CMT-type extended-spectrum beta-lactamases. |
| AID533001 | Antibacterial activity against VIM-2 producing Pseudomonas aeruginosa isolate P67 exhibiting PFGE J pattern by 2-fold agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | Nationwide investigation of extended-spectrum beta-lactamases, metallo-beta-lactamases, and extended-spectrum oxacillinases produced by ceftazidime-resistant Pseudomonas aeruginosa strains in France. |
| AID565509 | Antibacterial activity against oprD, mexB, mexY and mexD expressing Pseudomonas aeruginosa isolate Paebeta-27 harboring A residue at 105 position in PDC- 7 by Etest method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Molecular epidemiology and mechanisms of carbapenem resistance in Pseudomonas aeruginosa. |
| AID519009 | Ratio of Kcat to Km for Beta-lactamase TEM-149 expressed in Escherichia coli HB101 | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | E240V substitution increases catalytic efficiency toward ceftazidime in a new natural TEM-type extended-spectrum beta-lactamase, TEM-149, from Enterobacter aerogenes and Serratia marcescens clinical isolates. |
| AID565774 | Antimicrobial activity against Pseudomonas aeruginosa OC 12070 expressing 11 fold elevated mexX expression and 10 fold elevated mexY expression by broth macrodilution method | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | Differential selection of single-step AmpC or efflux mutants of Pseudomonas aeruginosa by using cefepime, ceftazidime, or ceftobiprole. |
| AID1373281 | Antimicrobial activity against Escherichia coli expressing beta-lactamase CTXM-3 by CLSI broth microdilution method | 2018 | Bioorganic & medicinal chemistry letters, 02-15, Volume: 28, Issue:4 | Optimization of novel monobactams with activity against carbapenem-resistant Enterobacteriaceae - Identification of LYS228. |
| AID495632 | Antimicrobial activity against Pseudomonas luteola expressing blaLUT-2 to blaLUT-6 by Etest method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Molecular and biochemical characterization of the natural chromosome-encoded class A beta-lactamase from Pseudomonas luteola. |
| AID530345 | Antimicrobial activity against Escherichia coli BicA expressing blaTEM-1, blaCTX-M-15 and qepA2 gene by disk diffusion method | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Plasmid-mediated quinolone resistance pump QepA2 in an Escherichia coli isolate from France. |
| AID498841 | Antimicrobial activity against carbapenem-resistant Klebsiella pneumoniae SX67 deficient in SHV-2, CTX-M-14, DHA-1, qnrB6/S1, aac(6')-Ib-cr, ompK35/36 by CLSI method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Phenotypic and genotypic characterization of Enterobacteriaceae with decreased susceptibility to carbapenems: results from large hospital-based surveillance studies in China. |
| AID518460 | Antimicrobial activity against Acinetobacter junii 15218 assessed as number of passages required for MIC to rise above 4 times original MIC | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli. |
| AID573199 | Antimicrobial activity against mutS::lox-deficient Pseudomonas aeruginosa PAOMSB biofilm harboring nfxB T380C mutant gene selected at 0.5 ug/ml of azithromycin after 2 passages by Etest method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Azithromycin in Pseudomonas aeruginosa biofilms: bactericidal activity and selection of nfxB mutants. |
| AID565775 | Antimicrobial activity against Pseudomonas aeruginosa OC 12070 expressing 27 fold elevated mexX expression and 49 fold elevated mexY expression by broth macrodilution method | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | Differential selection of single-step AmpC or efflux mutants of Pseudomonas aeruginosa by using cefepime, ceftazidime, or ceftobiprole. |
| AID540211 | Fraction unbound in human after iv administration | 2008 | Drug metabolism and disposition: the biological fate of chemicals, Jul, Volume: 36, Issue:7 | Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. |
| AID1079934 | Highest frequency of acute liver toxicity observed during clinical trials, expressed as a percentage. [column '% AIGUE' in source] | |||
| AID521353 | Antimicrobial activity against Streptococcus pneumoniae isolate k-421 obtained from ear of patient | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Highly variable penicillin resistance determinants PBP 2x, PBP 2b, and PBP 1a in isolates of two Streptococcus pneumoniae clonal groups, Poland 23F-16 and Poland 6B-20. |
| AID535753 | Antimicrobial activity against community-acquired Klebsiella pneumoniae expressing extended spectrum beta-lactamase obtained from patient with intra-abdominal infection assessed as susceptible isolates by EUCAST method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Incidence and antimicrobial susceptibility of Escherichia coli and Klebsiella pneumoniae with extended-spectrum beta-lactamases in community- and hospital-associated intra-abdominal infections in Europe: results of the 2008 Study for Monitoring Antimicrob |
| AID565198 | Antimicrobial activity against Klebsiella pneumoniae isolate A-1797 expressing VIM-1 and KPC-2 genes by microdilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Emerging Klebsiella pneumoniae isolates coproducing KPC-2 and VIM-1 carbapenemases. |
| AID583644 | Neurotoxicity in febrile neutropenic patient assessed as myoclonia at 2 g administered as 30 mins infusion every 8 hrs | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | High cefepime plasma concentrations and neurological toxicity in febrile neutropenic patients with mild impairment of renal function. |
| AID1373308 | Antimicrobial activity against Escherichia coli expressing beta-lactamase SPM-1 by CLSI broth microdilution method | 2018 | Bioorganic & medicinal chemistry letters, 02-15, Volume: 28, Issue:4 | Optimization of novel monobactams with activity against carbapenem-resistant Enterobacteriaceae - Identification of LYS228. |
| AID545437 | Antimicrobial activity against extended-spectrum beta-lactamase-negative Escherichia coli obtained from patient with complicated intra-abdominal infection assessed as percent susceptible isolates by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Susceptibility of gram-negative pathogens isolated from patients with complicated intra-abdominal infections in the United States, 2007-2008: results of the Study for Monitoring Antimicrobial Resistance Trends (SMART). |
| AID325198 | Antibacterial activity against Moraxella catarrhalis ATCC 43617 by standard serial agar dilution method | 2008 | Bioorganic & medicinal chemistry, Feb-15, Volume: 16, Issue:4 | A novel series of parenteral cephalosporins exhibiting potent activities against both Pseudomonas aeruginosa and other gram-negative pathogens. Part 2: Synthesis and structure-activity relationships. |
| AID519640 | Antimicrobial activity against Escherichia coli AB14156 harboring beta-lactamase CTX-M-42 Pro167Thr mutant gene by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Convergent in vivo and in vitro selection of ceftazidime resistance mutations at position 167 of CTX-M-3 beta-lactamase in hypermutable Escherichia coli strains. |
| AID424851 | Antibacterial activity in Escherichia coli infected patient assessed as mortality after 28 days | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Failure of current cefepime breakpoints to predict clinical outcomes of bacteremia caused by gram-negative organisms. |
| AID285688 | Antimicrobial susceptibility of carbapenem-resistant Pseudomonas aeruginosa PA2404 isolate expressing carbapenemase KPC2 | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | First identification of Pseudomonas aeruginosa isolates producing a KPC-type carbapenem-hydrolyzing beta-lactamase. |
| AID561674 | Antimicrobial activity against Pseudomonas aeruginosa isolate OC14812 harboring plasmid MexZ expressing mexXY gene by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Effect of MexXY overexpression on ceftobiprole susceptibility in Pseudomonas aeruginosa. |
| AID545452 | Antimicrobial activity against extended-spectrum beta-lactamase-positive Proteus mirabilis assessed as percent susceptible isolates by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Susceptibility of gram-negative pathogens isolated from patients with complicated intra-abdominal infections in the United States, 2007-2008: results of the Study for Monitoring Antimicrobial Resistance Trends (SMART). |
| AID584560 | Antimicrobial activity against Acinetobacter lwoffii isolate G expressing beta-lactamase OXA-58 isolated from tracheal secretion of patient by vitek 2 system | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | In vivo selection of a missense mutation in adeR and conversion of the novel blaOXA-164 gene into blaOXA-58 in carbapenem-resistant Acinetobacter baumannii isolates from a hospitalized patient. |
| AID531752 | Antibacterial activity against Pseudomonas aeruginosa 3308 harboring pNF225 carrying nfxB by twofold serial dilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Resistance and virulence of Pseudomonas aeruginosa clinical strains overproducing the MexCD-OprJ efflux pump. |
| AID561664 | Antimicrobial activity against Pseudomonas aeruginosa isolate OC14551 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Effect of MexXY overexpression on ceftobiprole susceptibility in Pseudomonas aeruginosa. |
| AID562776 | Antimicrobial activity against Escherichia coli DH10B by broth microdilution method in presence of clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | TEM-168, a heretofore laboratory-derived TEM beta-lactamase variant found in an Escherichia coli clinical isolate. |
| AID534302 | Antimicrobial activity against metallo-beta-lactamase-negative Pseudomonas aeruginosa isolate PA479 | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | First survey of metallo-beta-lactamases in clinical isolates of Pseudomonas aeruginosa in a German university hospital. |
| AID285630 | Antimicrobial activity against Pseudomonas aeruginosa 9B5 tracheal isolates from mechanically ventilated chronic respiratory insufficiency patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID521285 | Antimicrobial activity against CTX-M-2 and TEM-1 producing Klebsiella pneumoniae transconjugants/transformants with PFGE pulsotype I by Etest | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Multiclonal outbreak of Klebsiella pneumoniae producing extended-spectrum beta-lactamase CTX-M-2 and novel variant CTX-M-59 in a neonatal intensive care unit in Brazil. |
| AID534632 | Antimicrobial activity against ESBL producing Escherichia coli assessed as resistant isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activity of doripenem, a carbapenem for the treatment of challenging infections caused by gram-negative bacteria, against recent clinical isolates from the United States. |
| AID521842 | Antibacterial activity against Escherichia coli J53 by CLSI method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Presence of plasmid-mediated quinolone resistance in Klebsiella pneumoniae isolates possessing blaKPC in the United States. |
| AID582763 | Antimicrobial activity against eaeA positive verocytotoxin-producing non-O157 Escherichia coli isolates obtained from human assessed as percentage of resistant isolates | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Antimicrobial resistance testing of verocytotoxin-producing Escherichia coli and first description of TEM-52 extended-spectrum β-lactamase in serogroup O26. |
| AID529899 | Antimicrobial activity against Leptospira weilii isolate 8 by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Antimicrobial susceptibilities of geographically diverse clinical human isolates of Leptospira. |
| AID498831 | Antimicrobial activity against Escherichia coli C600 by CLSI method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Phenotypic and genotypic characterization of Enterobacteriaceae with decreased susceptibility to carbapenems: results from large hospital-based surveillance studies in China. |
| AID541023 | Ratio of Kcat to Km for Burkholderia cenocepacia 07-34 beta-lactamase PenB1 expressed in Escherichia coli Top10 | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Naturally occurring Class A ss-lactamases from the Burkholderia cepacia complex. |
| AID533566 | Antimicrobial activity against Pseudomonas aeruginosa isolate PA462 expressing VIM-2 beta-lactamase | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | First survey of metallo-beta-lactamases in clinical isolates of Pseudomonas aeruginosa in a German university hospital. |
| AID524746 | Antimicrobial activity against Escherichia coli GB20 harboring V27A, Q38R, A77V, P167S mutation in beta lactamase CTX-M-3 by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Mutational events in cefotaximase extended-spectrum beta-lactamases of the CTX-M-1 cluster involved in ceftazidime resistance. |
| AID567310 | Antimicrobial activity against SHV-12 ESBL producing Pseudomonas aeruginosa isolate 2201 isolated from burn patient by broth microdilution method in presence of beta-lactamase inhibitor clavulanic acid | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Acquisition of a transposon encoding extended-spectrum beta-lactamase SHV-12 by Pseudomonas aeruginosa isolates during the clinical course of a burn patient. |
| AID495510 | Antibacterial activity against Acinetobacter baumannii BM4454 by antimicrobial susceptibility assay | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Screening and quantification of the expression of antibiotic resistance genes in Acinetobacter baumannii with a microarray. |
| AID405818 | Antimicrobial activity against Acinetobacter sp. 5248 isolate harboring bla IMP-1 carrying integron In86 containing aminoglycoside resistance gene aac(6')-3 | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | Characterization of an integron carrying blaIMP-1 and a new aminoglycoside resistance gene, aac(6')-31, and its dissemination among genetically unrelated clinical isolates in a Brazilian hospital. |
| AID368476 | Antibacterial activity against Pseudomonas aeruginosa 7052 producing beta lactamase VIM2 by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID564534 | Antimicrobial activity against Escherichia coli TOP10 harboring pADC-33 plasmid carrying entire blaAmpC gene with alanine residue deletion at 215 position and R210P substitution by Etest method | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | Extended-spectrum cephalosporinase in Acinetobacter baumannii. |
| AID560080 | Antimicrobial activity against Pseudomonas aeruginosa isolate 1037 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | In vitro activity of ceftaroline alone and in combination against clinical isolates of resistant gram-negative pathogens, including beta-lactamase-producing Enterobacteriaceae and Pseudomonas aeruginosa. |
| AID564528 | Antimicrobial activity against Escherichia coli TOP10 harboring pADC-50 plasmid by Etest method | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | Extended-spectrum cephalosporinase in Acinetobacter baumannii. |
| AID285618 | Antimicrobial activity against Pseudomonas aeruginosa 5F8 tracheal isolates from mechanically ventilated chronic respiratory insufficiency patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID555211 | Antibacterial activity against Acinetobacter genomosp. 3 isolate 109 by Etest method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Genetic variability among ampC genes from acinetobacter genomic species 3. |
| AID1320835 | Activity of native signal containing Klebsiella pneumoniae OXA-48 by Michaelis-Menten kinetics assay | 2016 | Journal of medicinal chemistry, 06-09, Volume: 59, Issue:11 | Screening and Design of Inhibitor Scaffolds for the Antibiotic Resistance Oxacillinase-48 (OXA-48) through Surface Plasmon Resonance Screening. |
| AID533763 | Antibacterial activity against OXA-19 producing Pseudomonas aeruginosa isolate P122 exhibiting PFGE A pattern by 2-fold agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | Nationwide investigation of extended-spectrum beta-lactamases, metallo-beta-lactamases, and extended-spectrum oxacillinases produced by ceftazidime-resistant Pseudomonas aeruginosa strains in France. |
| AID528823 | Antimicrobial activity against carbapenem-resistant Pseudomonas aeruginosa isolated from ICU patient blood assessed as resistant isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Antimicrobial-resistant pathogens in intensive care units in Canada: results of the Canadian National Intensive Care Unit (CAN-ICU) study, 2005-2006. |
| AID567320 | Antimicrobial activity against Escherichia coli ML4909 by broth dilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Chromosomally encoded blaCMY-2 located on a novel SXT/R391-related integrating conjugative element in a Proteus mirabilis clinical isolate. |
| AID1225777 | Antibacterial activity against Enterobacter aerogenes EA1028 expressing OXA-30 by broth microdilution method | 2015 | Journal of medicinal chemistry, May-14, Volume: 58, Issue:9 | Discovery of a Cyclic Boronic Acid β-Lactamase Inhibitor (RPX7009) with Utility vs Class A Serine Carbapenemases. |
| AID522025 | Antimicrobial activity against Escherichia coli isolate A expressing beta-lactamase OXA-48 and TEM-150 by Etest method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Spread of OXA-48-encoding plasmid in Turkey and beyond. |
| AID508488 | Antimicrobial activity against Pseudomonas aeruginosa isolate OS-210 producing metallo-beta-lactamase VIM2 by Etest | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Molecular epidemiology of metallo-beta-lactamase-producing Pseudomonas aeruginosa isolates from Norway and Sweden shows import of international clones and local clonal expansion. |
| AID285639 | Antimicrobial activity against Pseudomonas aeruginosa 13D6 tracheal isolates from mechanically ventilated chronic respiratory insufficiency patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID561443 | Antibacterial activity against Escherichia coli 34943 harboring beta-lactamase CMY-44 gene by Etest method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Reduced susceptibility to cefepime among Escherichia coli clinical isolates producing novel variants of CMY-2 beta-lactamase. |
| AID1079931 | Moderate liver toxicity, defined via clinical-chemistry results: ALT or AST serum activity 6 times the normal upper limit (N) or alkaline phosphatase serum activity of 1.7 N. Value is number of references indexed. [column 'BIOL' in source] | |||
| AID499064 | Antimicrobial activity against carbapenem-resistant Enterobacter cloacae GX56 deficient in ompC and expressing low levels of ompF DE by CLSI method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Phenotypic and genotypic characterization of Enterobacteriaceae with decreased susceptibility to carbapenems: results from large hospital-based surveillance studies in China. |
| AID373054 | Antimicrobial activity against Escherichia coli BL21(DE3) carrying pET9a expressing Bacillus clausii beta-lactamase BCL1 by agar-dilution technique | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Molecular and biochemical characterization of the chromosome-encoded class A beta-lactamase BCL-1 from Bacillus clausii. |
| AID535173 | Antimicrobial activity against imipenem non-susceptible Acinetobacter assessed as resistant isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activity of doripenem, a carbapenem for the treatment of challenging infections caused by gram-negative bacteria, against recent clinical isolates from the United States. |
| AID534630 | Antimicrobial activity against ESBL producing Escherichia coli assessed as susceptible isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activity of doripenem, a carbapenem for the treatment of challenging infections caused by gram-negative bacteria, against recent clinical isolates from the United States. |
| AID285671 | Antimicrobial activity against Pseudomonas aeruginosa 24E2 tracheal isolates from mechanically ventilated chronic respiratory insufficiency patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID520717 | Antibacterial activity against Acinetobacter baumannii CIP7010 harboring pOXA-97 by disk diffusion method | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Carbapenem-resistant Acinetobacter baumannii isolates from Tunisia producing the OXA-58-like carbapenem-hydrolyzing oxacillinase OXA-97. |
| AID520876 | Antibacterial activity against Achromobacter xylosoxidans CIP69598 by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Characterization of a naturally occurring class D beta-lactamase from Achromobacter xylosoxidans. |
| AID285616 | Antimicrobial activity against Pseudomonas aeruginosa 3E2 tracheal isolates from mechanically ventilated chronic respiratory insufficiency patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID560119 | Antimicrobial activity against Acinetobacter baumannii by disk diffusion method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Genetic and biochemical characterization of the first extended-spectrum CARB-type beta-lactamase, RTG-4, from Acinetobacter baumannii. |
| AID540221 | Volume of distribution at steady state in human after iv administration | 2005 | Journal of pharmaceutical sciences, Jul, Volume: 94, Issue:7 | Extrapolation of human pharmacokinetic parameters from rat, dog, and monkey data: Molecular properties associated with extrapolative success or failure. |
| AID521836 | Antibacterial activity against Escherichia coli J53 transconjugated with Klebsiella pneumoniae isolate VA367 containing blaKPC-3, qnrB19, blaTEM-1, blaSHV-11, aac(6')-1b genes by CLSI method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Presence of plasmid-mediated quinolone resistance in Klebsiella pneumoniae isolates possessing blaKPC in the United States. |
| AID521831 | Antimicrobial activity against Streptococcus pneumoniae isolated from meningitis patient assessed as percent resistant isolates by CLSI method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Clonal spread of highly beta-lactam-resistant Streptococcus pneumoniae isolates in Taiwan. |
| AID285269 | Activity of Escherichia coli BL21(DE3) beta-lactamase TEM28 | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Evolution of TEM-type enzymes: biochemical and genetic characterization of two new complex mutant TEM enzymes, TEM-151 and TEM-152, from a single patient. |
| AID564535 | Antimicrobial activity against Escherichia coli TOP10 harboring pADC-11 plasmid carrying entire blaAmpC gene with alanine residue insertion at 215 position and R210P substitution by Etest method | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | Extended-spectrum cephalosporinase in Acinetobacter baumannii. |
| AID544964 | Antimicrobial activity against Klebsiella pneumoniae expressing beta-lactamase DHA by Etest | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Characterization and sequence analysis of extended-spectrum-{beta}-lactamase-encoding genes from Escherichia coli, Klebsiella pneumoniae, and Proteus mirabilis isolates collected during tigecycline phase 3 clinical trials. |
| AID588215 | FDA HLAED, alkaline phosphatase increase | 2004 | Current drug discovery technologies, Dec, Volume: 1, Issue:4 | Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. |
| AID498836 | Antimicrobial activity against carbapenem-resistant Klebsiella pneumoniae PU5 deficient in SHV-12, DHA-1, aac(6')-Ib-cr, ompK35/36 by CLSI method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Phenotypic and genotypic characterization of Enterobacteriaceae with decreased susceptibility to carbapenems: results from large hospital-based surveillance studies in China. |
| AID559264 | Antimicrobial activity against rifampin-resistant Escherichia coli J53 transconjugated with Proteus vulgaris Pv5 expressing beta-lactamase PER-1 by disk diffusion method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Emergence of extended-spectrum beta-lactamase PER-1 in Proteus vulgaris and Providencia stuartii isolates from Algiers, Algeria. |
| AID560085 | Bactericidal activity against Pseudomonas aeruginosa isolate 796 at 1/4 times MIC after 24 hrs by time kill analysis | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | In vitro activity of ceftaroline alone and in combination against clinical isolates of resistant gram-negative pathogens, including beta-lactamase-producing Enterobacteriaceae and Pseudomonas aeruginosa. |
| AID285658 | Antimicrobial activity against Pseudomonas aeruginosa 19E12 tracheal isolates from mechanically ventilated chronic respiratory insufficiency patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID574427 | Antimicrobial activity against Escherichia coli isolate 360 expressing beta-lactamase KPC2, CTX-M-15, OXA-9, TEM and PFGE cluster 1 isolated from urine of patient by vitek-2 method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Carbapenem-resistant KPC-2-producing Escherichia coli in a Tel Aviv Medical Center, 2005 to 2008. |
| AID325195 | Antibacterial activity against imipenem-resistant Pseudomonas aeruginosa SR-6554 by standard serial agar dilution method | 2008 | Bioorganic & medicinal chemistry, Feb-15, Volume: 16, Issue:4 | A novel series of parenteral cephalosporins exhibiting potent activities against both Pseudomonas aeruginosa and other gram-negative pathogens. Part 2: Synthesis and structure-activity relationships. |
| AID498825 | Antimicrobial activity against Citrobacter freundii SZ62T expressing IMP-4, qnrS1by CLSI method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Phenotypic and genotypic characterization of Enterobacteriaceae with decreased susceptibility to carbapenems: results from large hospital-based surveillance studies in China. |
| AID564468 | Antimicrobial activity against Pseudomonas aeruginosa isolate 1093 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | In vivo efficacy of 1- and 2-gram human simulated prolonged infusions of doripenem against Pseudomonas aeruginosa. |
| AID511287 | Antibacterial activity against Pseudomonas aeruginosa NL68 expressing GES-13 beta lactamase | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | GES-13, a beta-lactamase variant possessing Lys-104 and Asn-170 in Pseudomonas aeruginosa. |
| AID533002 | Antibacterial activity against VEB-1a and OXA-10 producing Pseudomonas aeruginosa isolate P151 exhibiting PFGE I pattern by 2-fold agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | Nationwide investigation of extended-spectrum beta-lactamases, metallo-beta-lactamases, and extended-spectrum oxacillinases produced by ceftazidime-resistant Pseudomonas aeruginosa strains in France. |
| AID535754 | Antimicrobial activity against hospital-acquired Klebsiella pneumoniae expressing extended spectrum beta-lactamase obtained from patient with intra-abdominal infection assessed as susceptible isolates by EUCAST method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Incidence and antimicrobial susceptibility of Escherichia coli and Klebsiella pneumoniae with extended-spectrum beta-lactamases in community- and hospital-associated intra-abdominal infections in Europe: results of the 2008 Study for Monitoring Antimicrob |
| AID584562 | Antimicrobial activity against Acinetobacter lwoffii isolate I expressing beta-lactamase OXA-58 isolated from tracheal secretion of patient by vitek 2 system | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | In vivo selection of a missense mutation in adeR and conversion of the novel blaOXA-164 gene into blaOXA-58 in carbapenem-resistant Acinetobacter baumannii isolates from a hospitalized patient. |
| AID285636 | Antimicrobial activity against Pseudomonas aeruginosa 12A7 tracheal isolates from mechanically ventilated chronic respiratory insufficiency patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID510512 | Antibacterial activity against Acinetobacter calcoaceticus/baumannii complex isolate W2AC8-S10 expressing OXA-51 | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Detection of KPC in Acinetobacter spp. in Puerto Rico. |
| AID518519 | Antimicrobial activity against Capnocytophaga sputigena isolate NOR after 2 days by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Characterization of CSP-1, a novel extended-spectrum beta-lactamase produced by a clinical isolate of Capnocytophaga sputigena. |
| AID534089 | Antibacterial activity against penicillin-susceptible Streptococcus pneumoniae assessed as percent susceptible isolates by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | In vitro activity of ceftaroline against Streptococcus pneumoniae isolates exhibiting resistance to penicillin, amoxicillin, and cefotaxime. |
| AID560554 | Antimicrobial activity against Proteus vulgaris Pv5 expressing beta-lactamase PER-1 by disk diffusion method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Emergence of extended-spectrum beta-lactamase PER-1 in Proteus vulgaris and Providencia stuartii isolates from Algiers, Algeria. |
| AID584839 | Antimicrobial activity against Escherichia coli DH10B by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | PER-6, an extended-spectrum beta-lactamase from Aeromonas allosaccharophila. |
| AID521832 | Antimicrobial activity against Streptococcus pneumoniae isolated from non-meningitis patient assessed as percent susceptible isolates by CLSI method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Clonal spread of highly beta-lactam-resistant Streptococcus pneumoniae isolates in Taiwan. |
| AID325188 | Antibacterial activity against Escherichia coli SR-21003 by standard serial agar dilution method | 2008 | Bioorganic & medicinal chemistry, Feb-15, Volume: 16, Issue:4 | A novel series of parenteral cephalosporins exhibiting potent activities against both Pseudomonas aeruginosa and other gram-negative pathogens. Part 2: Synthesis and structure-activity relationships. |
| AID584559 | Antimicrobial activity against Acinetobacter lwoffii isolate F expressing beta-lactamase OXA-164 isolated from tracheostoma of patient by vitek 2 system | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | In vivo selection of a missense mutation in adeR and conversion of the novel blaOXA-164 gene into blaOXA-58 in carbapenem-resistant Acinetobacter baumannii isolates from a hospitalized patient. |
| AID534296 | Antimicrobial activity against Pseudomonas aeruginosa isolate PA477 expressing VIM-2 beta-lactamase | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | First survey of metallo-beta-lactamases in clinical isolates of Pseudomonas aeruginosa in a German university hospital. |
| AID498802 | Antimicrobial activity against carbapenem-resistant Klebsiella pneumoniae ZJ18 deficient in KPC-2, SHV-28, DHA-1, ompK35 by CLSI method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Phenotypic and genotypic characterization of Enterobacteriaceae with decreased susceptibility to carbapenems: results from large hospital-based surveillance studies in China. |
| AID1320836 | Activity of native signal containing Klebsiella pneumoniae OXA-48 assessed as ratio of Kcat to Km by Michaelis-Menten kinetics assay | 2016 | Journal of medicinal chemistry, 06-09, Volume: 59, Issue:11 | Screening and Design of Inhibitor Scaffolds for the Antibiotic Resistance Oxacillinase-48 (OXA-48) through Surface Plasmon Resonance Screening. |
| AID567282 | Ratio of Kcat to Km for Acinetobacter baumannii ADC-11 beta-lactamase | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | Extended-spectrum cephalosporinase in Acinetobacter baumannii. |
| AID573195 | Antimicrobial activity against Pseudomonas aeruginosa PAO1 A biofilm harboring deletion mutation at nucleotide 231-244 in nfxB gene selected at 1 ug/ml of azithromycin after 4 passages by Etest method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Azithromycin in Pseudomonas aeruginosa biofilms: bactericidal activity and selection of nfxB mutants. |
| AID373044 | Antimicrobial activity against imipenem and meropenem-resistant Acinetobacter baumannii isolate CY6 by CLSI agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Molecular epidemiology of clinical isolates of carbapenem-resistant Acinetobacter spp. from Chinese hospitals. |
| AID567745 | Antimicrobial activity against Pseudomonas aeruginosa OC 11678 expressing 29 fold elevated AmpC expression by broth macrodilution method | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | Differential selection of single-step AmpC or efflux mutants of Pseudomonas aeruginosa by using cefepime, ceftazidime, or ceftobiprole. |
| AID583082 | Ratio of Kcat to Km for Escherichia coli BL21(DE3) wild-type VIM-2 beta-lactamase by spectrophotometer | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | Mutational analysis of VIM-2 reveals an essential determinant for metallo-beta-lactamase stability and folding. |
| AID535139 | Antimicrobial activity against Ceftazidime non-susceptible Pseudomonas aeruginosa assessed as resistant isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activity of doripenem, a carbapenem for the treatment of challenging infections caused by gram-negative bacteria, against recent clinical isolates from the United States. |
| AID368526 | Ratio of Kcat to Km of Enterobacter cloacae 4080 AmpC (P99) assessed as drug hydrolysis by spectrophotometry relative to cephaloridine | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID529459 | Antimicrobial activity against Escherichia coli J53 harboring beta-lactamase Oxa-48 by Etest | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Spread of OXA-48-positive carbapenem-resistant Klebsiella pneumoniae isolates in Istanbul, Turkey. |
| AID545422 | Antimicrobial activity against Citrobacter freundii obtained from patient with complicated intra-abdominal infection assessed as percent susceptible isolates by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Susceptibility of gram-negative pathogens isolated from patients with complicated intra-abdominal infections in the United States, 2007-2008: results of the Study for Monitoring Antimicrobial Resistance Trends (SMART). |
| AID394684 | Antibacterial activity against wild type Pseudomonas aeruginosa PAO1 by macrodilution technique | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10 | Pseudomonas aeruginosa may accumulate drug resistance mechanisms without losing its ability to cause bloodstream infections. |
| AID283541 | Antibacterial activity against Pseudomonas aeruginosa FE53GU with inactivated mexZ, nuoG and galU genes by microdilution method | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3 | Cumulative effects of several nonenzymatic mechanisms on the resistance of Pseudomonas aeruginosa to aminoglycosides. |
| AID534652 | Antimicrobial activity against ESBL producing Klebsiella pneumoniae assessed as resistant isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activity of doripenem, a carbapenem for the treatment of challenging infections caused by gram-negative bacteria, against recent clinical isolates from the United States. |
| AID544585 | Antimicrobial activity against Escherichia coli DH5[alpha] isolate GC 8133 expressing bla TEM-55 gene by microdilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Pyrosequencing using the single-nucleotide polymorphism protocol for rapid determination of TEM- and SHV-type extended-spectrum beta-lactamases in clinical isolates and identification of the novel beta-lactamase genes blaSHV-48, blaSHV-105, and blaTEM-155 |
| AID324864 | Antimicrobial activity against Acinetobacter baumannii A24D after 4 days by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Tigecycline Efflux as a Mechanism for Nonsusceptibility in Acinetobacter baumannii. |
| AID541016 | Antimicrobial activity against Escherichia coli TOP10 harboring beta-lactamase PenB1 | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Naturally occurring Class A ss-lactamases from the Burkholderia cepacia complex. |
| AID510509 | Antibacterial activity against Acinetobacter calcoaceticus/baumannii complex isolate MC4AC9-30 expressing KPC beta lactamase | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Detection of KPC in Acinetobacter spp. in Puerto Rico. |
| AID535061 | Antimicrobial activity against Acinetobacter genomic species 13TU ATCC 17903 harboring pYMAb3 plasmid by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | Contribution of a plasmid-borne blaOXA-58 gene with its hybrid promoter provided by IS1006 and an ISAba3-like element to beta-lactam resistance in acinetobacter genomic species 13TU. |
| AID571696 | Antimicrobial activity against Acinetobacter baumannii alpha clonal group isolate 5 expressing ampC, ompA, adeB, adeM, aacC1, aadA1 by Etest method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Correlation of antimicrobial resistance with beta-lactamases, the OmpA-like porin, and efflux pumps in clinical isolates of Acinetobacter baumannii endemic to New York City. |
| AID444050 | Fraction unbound in human plasma | 2010 | Journal of medicinal chemistry, Feb-11, Volume: 53, Issue:3 | Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. |
| AID564532 | Antimicrobial activity against Escherichia coli TOP10 harboring pADC-33 plasmid with entire blaAmpC gene with alanine residue deletion at 215 position by Etest method | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | Extended-spectrum cephalosporinase in Acinetobacter baumannii. |
| AID279816 | Antimicrobial activity against Escherichia coli DH5alpha by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2 | Plasmid-mediated KPC-2 in a Klebsiella pneumoniae isolate from China. |
| AID573205 | Antimicrobial activity against mutS::lox-deficient Pseudomonas aeruginosa PAOMSA biofilm harboring nfxB T86C mutant gene selected at 4 ug/ml of azithromycin after 4 passages by Etest method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Azithromycin in Pseudomonas aeruginosa biofilms: bactericidal activity and selection of nfxB mutants. |
| AID574433 | Antimicrobial activity against Escherichia coli isolate 543T expressing beta-lactamase KPC2 and PFGE cluster 4 isolated from synovial fluid of patient by vitek-2 method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Carbapenem-resistant KPC-2-producing Escherichia coli in a Tel Aviv Medical Center, 2005 to 2008. |
| AID373751 | Antibacterial activity against imipenem-susceptible Acinetobacter baumannii ATCC 19606 by broth dilution method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | An OXA-66/OXA-51-like carbapenemase and possibly an efflux pump are associated with resistance to imipenem in Acinetobacter baumannii. |
| AID521282 | Antimicrobial activity against CTX-M-2 and TEM-1 producing Klebsiella pneumoniae transconjugants/transformants with PFGE pulsotype F by Etest | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Multiclonal outbreak of Klebsiella pneumoniae producing extended-spectrum beta-lactamase CTX-M-2 and novel variant CTX-M-59 in a neonatal intensive care unit in Brazil. |
| AID1318935 | Antibacterial activity against multidrug-resistant/tobramycin-susceptible Pseudomonas aeruginosa isolate 83182 | 2016 | Journal of medicinal chemistry, 09-22, Volume: 59, Issue:18 | Hybrid Antibiotic Overcomes Resistance in P. aeruginosa by Enhancing Outer Membrane Penetration and Reducing Efflux. |
| AID368321 | Antibacterial activity against Klebsiella pneumoniae 4238 producing beta lactamase SHV1 by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID528826 | Antimicrobial activity against ESBL producing Klebsiella pneumoniae isolated from ICU patient wound assessed as resistant isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Antimicrobial-resistant pathogens in intensive care units in Canada: results of the Canadian National Intensive Care Unit (CAN-ICU) study, 2005-2006. |
| AID535644 | Antimicrobial activity against Group B streptococcus serotype Ib N2 harboring E63K mutation in PBP 2A and L41S mutation in PBP 1B by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | Genetic heterogeneity in pbp genes among clinically isolated group B Streptococci with reduced penicillin susceptibility. |
| AID571222 | Antimicrobial activity against Pseudomonas aeruginosa isolate 164CD obtained from patient with non-cystic fibrosis by Etest | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Role of ampD homologs in overproduction of AmpC in clinical isolates of Pseudomonas aeruginosa. |
| AID520805 | Antimicrobial activity against Escherichia coli str. K-12 substr. DH10B harboring plasmid CTX-M-59 | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Multiclonal outbreak of Klebsiella pneumoniae producing extended-spectrum beta-lactamase CTX-M-2 and novel variant CTX-M-59 in a neonatal intensive care unit in Brazil. |
| AID368527 | Activity of Enterobacter cloacae 908R AmpC assessed as drug hydrolysis by spectrophotometry | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID558050 | Antimicrobial activity against blaKPC-positive Klebsiella oxytoca S13 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Genetic organization of transposase regions surrounding blaKPC carbapenemase genes on plasmids from Klebsiella strains isolated in a New York City hospital. |
| AID546176 | Antimicrobial activity against AmpC overproducing Pseudomonas aeruginosa isolate Pae-beta-16 with PDC-3 variant by Etest | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Extended-spectrum cephalosporinases in Pseudomonas aeruginosa. |
| AID285668 | Antimicrobial activity against Pseudomonas aeruginosa 24D1 tracheal isolates from mechanically ventilated chronic respiratory insufficiency patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID535882 | Antimicrobial activity against aac(6')-Ib-cr-positive Klebsiella pneumoniae JN132T harboring qnrB gene by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | High prevalence of plasmid-mediated quinolone resistance genes qnr and aac(6')-Ib-cr in clinical isolates of Enterobacteriaceae from nine teaching hospitals in China. |
| AID285338 | Antimicrobial activity against streptomycin-resistant Escherichia coli J53 transconjugant with qnrA1 producing urinary specimen isolate 13.52 by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | First report of plasmid-mediated qnrA1 in a ciprofloxacin-resistant Escherichia coli strain in Latin America. |
| AID573383 | Antibacterial activity against beta lactamase-positive Haemophilus influenzae assessed as susceptible isolates by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID544584 | Antimicrobial activity against Escherichia coli ATCC 25922 by microdilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Pyrosequencing using the single-nucleotide polymorphism protocol for rapid determination of TEM- and SHV-type extended-spectrum beta-lactamases in clinical isolates and identification of the novel beta-lactamase genes blaSHV-48, blaSHV-105, and blaTEM-155 |
| AID761208 | Antibacterial activity against Escherichia coli expressing CTX-M by broth microdilution method | 2013 | Journal of medicinal chemistry, Jul-11, Volume: 56, Issue:13 | Pyridone-conjugated monobactam antibiotics with gram-negative activity. |
| AID340730 | Antimicrobial activity against Enterobacter isolates producing extended-spectrum beta-lactamase TEM-ES by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8 | Extended-spectrum beta-lactamases of the CTX-M type now in Switzerland. |
| AID518729 | Ratio of Kcat to Km for Pseudomonas stutzeri beta-lactamase DIM-1by UV-spectrophotometry | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Characterization of DIM-1, an integron-encoded metallo-beta-lactamase from a Pseudomonas stutzeri clinical isolate in the Netherlands. |
| AID555555 | Antimicrobial activity against Pseudomonas aeruginosa isolate 26285 expressing IMP-13 beta lactamase gene by Etest | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | First organisms with acquired metallo-beta-lactamases (IMP-13, IMP-22, and VIM-2) reported in Austria. |
| AID573371 | Antibacterial activity against ceftazidime-susceptible Serratia marcescens assessed as susceptible isolates by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID511680 | Antimicrobial activity against Pseudomonas aeruginosa clinical isolate assessed as resistant isolates selected in vitro after antipseudomonal treatment of intensive care unit patient by by CLSI method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Activity of a new cephalosporin, CXA-101 (FR264205), against beta-lactam-resistant Pseudomonas aeruginosa mutants selected in vitro and after antipseudomonal treatment of intensive care unit patients. |
| AID586058 | Antimicrobial activity against Acinetobacter baumannii clinical isolate harboring chromosomally encoded ISAba1-blaOXA-51-like gene with fxsA upstream sequence by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Emergence and Distribution of Plasmids Bearing the blaOXA-51-like gene with an upstream ISAba1 in carbapenem-resistant Acinetobacter baumannii isolates in Taiwan. |
| AID373052 | Antimicrobial activity against Escherichia coli DH10B carrying pJIM2246 expressing Bacillus clausii NR beta-lactamase BCL1 by agar-dilution technique | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Molecular and biochemical characterization of the chromosome-encoded class A beta-lactamase BCL-1 from Bacillus clausii. |
| AID279940 | Antibiotic susceptibility by resistance against MDR Pseudomonas aeruginosa from samples collected from patients | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2 | Clinical prediction tool to identify patients with Pseudomonas aeruginosa respiratory tract infections at greatest risk for multidrug resistance. |
| AID565716 | Antibacterial activity against oprD, mexB, mexY and mexD expressing Pseudomonas aeruginosa isolate Paebeta-21 harboring A residue at 105 position in PDC- 4 and polymorphic OprD gene by Etest method in presence of cloxacillin | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Molecular epidemiology and mechanisms of carbapenem resistance in Pseudomonas aeruginosa. |
| AID583089 | Ratio of Kcat to Km for Escherichia coli XL1-Blue wild-type VIM-2 beta-lactamase by spectrophotometer | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | Mutational analysis of VIM-2 reveals an essential determinant for metallo-beta-lactamase stability and folding. |
| AID535063 | Antimicrobial activity against Acinetobacter genomic species 13TU ATCC 17903 harboring pOXA-58-6 plasmid by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | Contribution of a plasmid-borne blaOXA-58 gene with its hybrid promoter provided by IS1006 and an ISAba3-like element to beta-lactam resistance in acinetobacter genomic species 13TU. |
| AID1318934 | Antibacterial activity against multidrug-resistant/tobramycin-susceptible Pseudomonas aeruginosa isolate 80621 | 2016 | Journal of medicinal chemistry, 09-22, Volume: 59, Issue:18 | Hybrid Antibiotic Overcomes Resistance in P. aeruginosa by Enhancing Outer Membrane Penetration and Reducing Efflux. |
| AID1079938 | Chronic liver disease either proven histopathologically, or through a chonic elevation of serum amino-transferase activity after 6 months. Value is number of references indexed. [column 'CHRON' in source] | |||
| AID520970 | Antibacterial activity against Escherichia coli harboring pNGR plasmid expressing blaKPC gene by Etest method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Genetic structures at the origin of acquisition of the beta-lactamase bla KPC gene. |
| AID535663 | Antimicrobial activity against aac(6')-Ib-cr-positive Enterobacter cloacae FJ63T harboring qnrS gene by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | High prevalence of plasmid-mediated quinolone resistance genes qnr and aac(6')-Ib-cr in clinical isolates of Enterobacteriaceae from nine teaching hospitals in China. |
| AID540217 | Volume of distribution at steady state in dog after iv administration | 2005 | Journal of pharmaceutical sciences, Jul, Volume: 94, Issue:7 | Extrapolation of human pharmacokinetic parameters from rat, dog, and monkey data: Molecular properties associated with extrapolative success or failure. |
| AID444052 | Hepatic clearance in human | 2010 | Journal of medicinal chemistry, Feb-11, Volume: 53, Issue:3 | Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. |
| AID528819 | Antimicrobial activity against carbapenem-resistant Enterobacter cloacae assessed as resistant isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Antimicrobial-resistant pathogens in intensive care units in Canada: results of the Canadian National Intensive Care Unit (CAN-ICU) study, 2005-2006. |
| AID508728 | Antibacterial activity against carbapenem-resistant Pseudomonas aeruginosa isolate 3C1 VAL6 by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2 | Activity of a new antipseudomonal cephalosporin, CXA-101 (FR264205), against carbapenem-resistant and multidrug-resistant Pseudomonas aeruginosa clinical strains. |
| AID554402 | Antimicrobial activity against Pseudomonas aeruginosa isolate 3066 obtained from cystic fibrosis patient by disk diffusion method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Efflux unbalance in Pseudomonas aeruginosa isolates from cystic fibrosis patients. |
| AID285599 | Antimicrobial activity against Pseudomonas aeruginosa 2A2 tracheal isolates from mechanically ventilated tuberculosis patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID574438 | Antimicrobial activity against Escherichia coli isolate 1679T expressing beta-lactamase KPC2, TEM and PFGE cluster 6 isolated from peritoneal fluid of patient by vitek-2 method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Carbapenem-resistant KPC-2-producing Escherichia coli in a Tel Aviv Medical Center, 2005 to 2008. |
| AID546418 | Antimicrobial activity against Pseudomonas aeruginosa KG2505a harboring recombinant pBB-PDC-3 by Etest | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Extended-spectrum cephalosporinases in Pseudomonas aeruginosa. |
| AID495654 | Antimicrobial activity against Pseudomonas aeruginosa 531 expressing beta-lactamase BEL-2 by solid agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | BEL-2, an extended-spectrum beta-lactamase with increased activity toward expanded-spectrum cephalosporins in Pseudomonas aeruginosa. |
| AID324858 | Antimicrobial activity against Acinetobacter baumannii A24A after 4 days by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Tigecycline Efflux as a Mechanism for Nonsusceptibility in Acinetobacter baumannii. |
| AID564225 | Antimicrobial activity against Escherichia coli TOP10 by Etest method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | OXA-143, a novel carbapenem-hydrolyzing class D beta-lactamase in Acinetobacter baumannii. |
| AID510505 | Antibacterial activity against Acinetobacter calcoaceticus/baumannii complex isolate M3AC9-4 expressing KPC beta lactamase | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Detection of KPC in Acinetobacter spp. in Puerto Rico. |
| AID528536 | Antimicrobial activity against penicillin-resistant Streptococcus agalactiae B514 by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | First molecular characterization of group B streptococci with reduced penicillin susceptibility. |
| AID534886 | Antimicrobial activity against Enterobacter cloacae with nonderepressed AmpC beta-lactamsae assessed as resistant isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activity of doripenem, a carbapenem for the treatment of challenging infections caused by gram-negative bacteria, against recent clinical isolates from the United States. |
| AID534904 | Antimicrobial activity against Citrobacter with nonderepressed AmpC beta-lactamsae assessed as susceptible isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activity of doripenem, a carbapenem for the treatment of challenging infections caused by gram-negative bacteria, against recent clinical isolates from the United States. |
| AID545425 | Antimicrobial activity against Enterobacter aerogenes obtained from patient with complicated intra-abdominal infection assessed as percent susceptible isolates by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Susceptibility of gram-negative pathogens isolated from patients with complicated intra-abdominal infections in the United States, 2007-2008: results of the Study for Monitoring Antimicrobial Resistance Trends (SMART). |
| AID565281 | Antibacterial activity against mexB and mexY expressing Pseudomonas aeruginosa PA-A2 harboring GyrA T83I, ParC S87L and IS1001 insertion at position 629 in OprD gene by Etest method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Nosocomial spread of colistin-only-sensitive sequence type 235 Pseudomonas aeruginosa isolates producing the extended-spectrum beta-lactamases GES-1 and GES-5 in Spain. |
| AID373754 | Antibacterial activity against imipenem-susceptible Acinetobacter baumannii ab8 by broth dilution method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | An OXA-66/OXA-51-like carbapenemase and possibly an efflux pump are associated with resistance to imipenem in Acinetobacter baumannii. |
| AID567731 | Antimicrobial activity against Pseudomonas aeruginosa OC 4351 by broth macrodilution method | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | Differential selection of single-step AmpC or efflux mutants of Pseudomonas aeruginosa by using cefepime, ceftazidime, or ceftobiprole. |
| AID534648 | Antimicrobial activity against Non-ESBL Klebsiella pneumoniae assessed as intermediate isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activity of doripenem, a carbapenem for the treatment of challenging infections caused by gram-negative bacteria, against recent clinical isolates from the United States. |
| AID564017 | Antibacterial activity against Pseudomonas aeruginosa PAO1 by Etest | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Detection of the novel extended-spectrum beta-lactamase OXA-161 from a plasmid-located integron in Pseudomonas aeruginosa clinical isolates from Spain. |
| AID535137 | Antimicrobial activity against Ceftazidime non-susceptible Pseudomonas aeruginosa assessed as susceptible isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activity of doripenem, a carbapenem for the treatment of challenging infections caused by gram-negative bacteria, against recent clinical isolates from the United States. |
| AID444056 | Fraction escaping gut-wall elimination in human | 2010 | Journal of medicinal chemistry, Feb-11, Volume: 53, Issue:3 | Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. |
| AID571918 | Antimicrobial activity against ISAba1 linked with the blaOXA-51-type beta-lactamase harboring Acinetobacter baumannii zeta clonal group isolate 23 expressing ampC, ompA, adeB, adeM, aadA1, aacA4, aacC2, aphA6 by Etest method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Correlation of antimicrobial resistance with beta-lactamases, the OmpA-like porin, and efflux pumps in clinical isolates of Acinetobacter baumannii endemic to New York City. |
| AID562331 | Antimicrobial activity against Escherichia coli DH5alpha harboring metallo-beta-lactamase IND-6 after 18 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | IND-6, a highly divergent IND-type metallo-beta-lactamase from Chryseobacterium indologenes strain 597 isolated in Burkina Faso. |
| AID535144 | Antimicrobial activity against imipenem non-susceptible Pseudomonas aeruginosa assessed as intermediate isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activity of doripenem, a carbapenem for the treatment of challenging infections caused by gram-negative bacteria, against recent clinical isolates from the United States. |
| AID1361168 | Antimicrobial activity against VIM-2 producing Pseudomonas aeruginosa SBRKM-28 in presence of human apo-transferrin by broth microdilution method | 2018 | European journal of medicinal chemistry, Jul-15, Volume: 155 | Cefiderocol (S-649266), A new siderophore cephalosporin exhibiting potent activities against Pseudomonas aeruginosa and other gram-negative pathogens including multi-drug resistant bacteria: Structure activity relationship. |
| AID567314 | Antimicrobial activity against SHV-12 ESBL producing Pseudomonas aeruginosa isolate 2205 isolated from burn patient by broth microdilution method in presence of beta-lactamase inhibitor clavulanic acid | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Acquisition of a transposon encoding extended-spectrum beta-lactamase SHV-12 by Pseudomonas aeruginosa isolates during the clinical course of a burn patient. |
| AID545428 | Antimicrobial activity against Enterobacter cloacae obtained from patient with complicated intra-abdominal infection assessed as percent susceptible isolates by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Susceptibility of gram-negative pathogens isolated from patients with complicated intra-abdominal infections in the United States, 2007-2008: results of the Study for Monitoring Antimicrobial Resistance Trends (SMART). |
| AID531966 | Antibacterial activity against Klebsiella pneumoniae urine isolate A28009 PFGE pattern A expressing KPC-2, TEM-1, SHV-11, CTX-M-2 beta-lactamase by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | First report of KPC-2-producing Klebsiella pneumoniae strains in Brazil. |
| AID1079942 | Steatosis, proven histopathologically. Value is number of references indexed. [column 'STEAT' in source] | |||
| AID341596 | Antibacterial activity against carbapenem-resistant blaKPC-encoding plasmid harboring Klebsiella pneumoniae 490 isolate producing KPC3 and TEM1 carbapenemases | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8 | Emergence of KPC-2 and KPC-3 in carbapenem-resistant Klebsiella pneumoniae strains in an Israeli hospital. |
| AID285637 | Antimicrobial activity against Pseudomonas aeruginosa 12B2 tracheal isolates from mechanically ventilated chronic respiratory insufficiency patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID518459 | Antimicrobial activity against Acinetobacter baumannii HPA74510 assessed as number of passages required for MIC to rise above 4 times original MIC | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli. |
| AID565514 | Antibacterial activity against mexB, mexY and mexD expressing Pseudomonas aeruginosa isolate Paebeta-21 harboring A residue at 105 position in PDC- 4 and polymorphic OprD gene by Etest method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Molecular epidemiology and mechanisms of carbapenem resistance in Pseudomonas aeruginosa. |
| AID535171 | Antimicrobial activity against imipenem non-susceptible Acinetobacter assessed as susceptible isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activity of doripenem, a carbapenem for the treatment of challenging infections caused by gram-negative bacteria, against recent clinical isolates from the United States. |
| AID535751 | Antimicrobial activity against community-acquired Klebsiella pneumoniae obtained from patient with intra-abdominal infection assessed as susceptible isolates by EUCAST method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Incidence and antimicrobial susceptibility of Escherichia coli and Klebsiella pneumoniae with extended-spectrum beta-lactamases in community- and hospital-associated intra-abdominal infections in Europe: results of the 2008 Study for Monitoring Antimicrob |
| AID565711 | Antibacterial activity against oprD, mexB, mexY and mexD expressing Pseudomonas aeruginosa isolate Paebeta-16 harboring A residue at 105 position in PDC- 3 by Etest method in presence of cloxacillin | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Molecular epidemiology and mechanisms of carbapenem resistance in Pseudomonas aeruginosa. |
| AID424853 | Antibacterial activity in Enterobacter sp. infected patient assessed as mortality after 28 days | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Failure of current cefepime breakpoints to predict clinical outcomes of bacteremia caused by gram-negative organisms. |
| AID368314 | Activity of Staphylococcus aureus betalactamase PC1 assessed as drug hydrolysis by spectrophotometry relative to cephaloridine | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID532394 | Antibacterial activity against VIM-1 producing Pseudomonas aeruginosa clone A2 isolate NA-14X-32 by Etest method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | First countrywide survey of acquired metallo-beta-lactamases in gram-negative pathogens in Italy. |
| AID530322 | Antimicrobial activity against Pseudomonas aeruginosa isolate PA-SL2 harboring blaVIM-13 gene by Etest method | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Characterization of the new metallo-beta-lactamase VIM-13 and its integron-borne gene from a Pseudomonas aeruginosa clinical isolate in Spain. |
| AID582972 | Antimicrobial activity against ampD::lox and nagZ::lox gene-deficient Pseudomonas aeruginosa PAO1 by Etest method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | NagZ inactivation prevents and reverts beta-lactam resistance, driven by AmpD and PBP 4 mutations, in Pseudomonas aeruginosa. |
| AID576280 | Antimicrobial activity against ESBL-positive Klebsiella pneumoniae 17830 harboring porin OmpK36V mutant gene by Etest | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | An ertapenem-resistant extended-spectrum-beta-lactamase-producing Klebsiella pneumoniae clone carries a novel OmpK36 porin variant. |
| AID498803 | Antimicrobial activity against Klebsiella pneumoniae ZJ18T expressing KPC-2, DHA-1 by CLSI method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Phenotypic and genotypic characterization of Enterobacteriaceae with decreased susceptibility to carbapenems: results from large hospital-based surveillance studies in China. |
| AID546179 | Antimicrobial activity against Pseudomonas aeruginosa isolate Pae-beta-19 with PDC-3 variant by Etest | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Extended-spectrum cephalosporinases in Pseudomonas aeruginosa. |
| AID283539 | Antibacterial activity against Pseudomonas aeruginosa FE57G with inactivated rplY and nuoG genes by microdilution method | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3 | Cumulative effects of several nonenzymatic mechanisms on the resistance of Pseudomonas aeruginosa to aminoglycosides. |
| AID424852 | Antibacterial activity in Pseudomonas aeruginosa infected patient assessed as mortality after 28 days | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Failure of current cefepime breakpoints to predict clinical outcomes of bacteremia caused by gram-negative organisms. |
| AID572130 | Antimicrobial activity against Acinetobacter baumannii nu clonal group isolate 32 expressing ampC, ompA, adeB, adeM, aadB, aadA2 by Etest method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Correlation of antimicrobial resistance with beta-lactamases, the OmpA-like porin, and efflux pumps in clinical isolates of Acinetobacter baumannii endemic to New York City. |
| AID522010 | Antimicrobial activity against Escherichia coli isolate TOP10 harboring pBIC containing beta-lactamase OXA-48 located within transposon Tn1999.2 by Etest method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Spread of OXA-48-encoding plasmid in Turkey and beyond. |
| AID587729 | Antimicrobial activity against Escherichia coli DH5alpha carrying empty pBC-SK after 18 hrs by microdilution broth method | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1 | Genetic context and biochemical characterization of the IMP-18 metallo-beta-lactamase identified in a Pseudomonas aeruginosa isolate from the United States. |
| AID373209 | Activity of Bacillus clausii NR beta-lactamase BCL1 expressed in Escherichia coli BL21 (DE3) | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Molecular and biochemical characterization of the chromosome-encoded class A beta-lactamase BCL-1 from Bacillus clausii. |
| AID522003 | Antimicrobial activity against Klebsiella pneumoniae isolate Kp7A expressing beta-lactamase OXA-48 by Etest method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Spread of OXA-48-encoding plasmid in Turkey and beyond. |
| AID368546 | Ratio of Kcat to Km of Pseudomonas aeruginosa 18SH AmpC assessed as drug hydrolysis by spectrophotometry relative to cephaloridine | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID495511 | Antibacterial activity against multidrug-resistant Acinetobacter baumannii BM4665 by antimicrobial susceptibility assay | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Screening and quantification of the expression of antibiotic resistance genes in Acinetobacter baumannii with a microarray. |
| AID499045 | Antimicrobial activity against carbapenem-resistant Klebsiella pneumoniae ZJ68T deficient in CTX-M-15, ompK35/36 by CLSI method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Phenotypic and genotypic characterization of Enterobacteriaceae with decreased susceptibility to carbapenems: results from large hospital-based surveillance studies in China. |
| AID520807 | Antimicrobial activity against CTX-M-2 and TEM-1 producing Klebsiella pneumoniae transconjugants/transformants with PFGE pulsotype A by Etest | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Multiclonal outbreak of Klebsiella pneumoniae producing extended-spectrum beta-lactamase CTX-M-2 and novel variant CTX-M-59 in a neonatal intensive care unit in Brazil. |
| AID530813 | Antibacterial activity against Escherichia coli J53 harboring plasmid pA-1carrying beta-lactamase OXA-48 by Etest method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Plasmid-encoded carbapenem-hydrolyzing beta-lactamase OXA-48 in an imipenem-susceptible Klebsiella pneumoniae strain from Belgium. |
| AID544495 | Ratio of MIC for Escherichia coli TOP10 harboring beta-lactamase KPC-2 to MIC for Escherichia coli TOP10 | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Phenotypic and enzymatic comparative analysis of the novel KPC variant KPC-5 and its evolutionary variants, KPC-2 and KPC-4. |
| AID546621 | Antimicrobial activity against Escherichia coli harboring plasmid pPCRScript by Etest | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Carbapenem resistance among Pseudomonas aeruginosa strains from India: evidence for nationwide endemicity of multiple metallo-beta-lactamase clones (VIM-2, -5, -6, and -11 and the newly characterized VIM-18). |
| AID560086 | Bactericidal activity against Pseudomonas aeruginosa isolate 956 at 1/4 times MIC after 24 hrs by time kill analysis | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | In vitro activity of ceftaroline alone and in combination against clinical isolates of resistant gram-negative pathogens, including beta-lactamase-producing Enterobacteriaceae and Pseudomonas aeruginosa. |
| AID520979 | Antibacterial activity against Pseudomonas aeruginosa KG2505 by Etest method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Genetic structures at the origin of acquisition of the beta-lactamase bla KPC gene. |
| AID524935 | Antimicrobial activity against Escherichia coli MI1443 harboring V27A, Q38R, N106S mutations in beta lactamase CTX-M-3 by E-test | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Mutational events in cefotaximase extended-spectrum beta-lactamases of the CTX-M-1 cluster involved in ceftazidime resistance. |
| AID562576 | Antimicrobial activity against Escherichia coli NO8-1503 harboring blaTEM-168 gene by broth microdilution method in presence of clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | TEM-168, a heretofore laboratory-derived TEM beta-lactamase variant found in an Escherichia coli clinical isolate. |
| AID559685 | Antibacterial activity against Acinetobacter baumannii BM4652 harboring plasmid IP847 | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | GES-11, a novel integron-associated GES variant in Acinetobacter baumannii. |
| AID499048 | Antimicrobial activity against carbapenem-resistant Klebsiella pneumoniae GZ83 deficient in SHV-11, CTX-M-14, ompK35/36 by CLSI method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Phenotypic and genotypic characterization of Enterobacteriaceae with decreased susceptibility to carbapenems: results from large hospital-based surveillance studies in China. |
| AID555209 | Antibacterial activity against Acinetobacter genomosp. 3 isolate 90 by Etest method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Genetic variability among ampC genes from acinetobacter genomic species 3. |
| AID285264 | Antimicrobial activity against Escherichia coli DH5-alpha TC1179 isolate expressing TEM-1 by disk diffusion assay | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Evolution of TEM-type enzymes: biochemical and genetic characterization of two new complex mutant TEM enzymes, TEM-151 and TEM-152, from a single patient. |
| AID520976 | Antibacterial activity against Pseudomonas aeruginosa KG2505 harboring pCOL plasmid by Etest method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Genetic structures at the origin of acquisition of the beta-lactamase bla KPC gene. |
| AID528525 | Antimicrobial activity against penicillin-resistant Streptococcus agalactiae B6 by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | First molecular characterization of group B streptococci with reduced penicillin susceptibility. |
| AID373761 | Antibacterial activity against imipenem-resistant Acinetobacter baumannii ab1265 by broth dilution method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | An OXA-66/OXA-51-like carbapenemase and possibly an efflux pump are associated with resistance to imipenem in Acinetobacter baumannii. |
| AID529666 | Ratio of Kcat to Km for Pseudomonas aeruginosa COL-1 beta-lactamase VIM-2 relative to cephaloridine | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | VIM-15 and VIM-16, two new VIM-2-like metallo-beta-lactamases in Pseudomonas aeruginosa isolates from Bulgaria and Germany. |
| AID545440 | Antimicrobial activity against Klebsiella pneumoniae assessed as percent susceptible isolates by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Susceptibility of gram-negative pathogens isolated from patients with complicated intra-abdominal infections in the United States, 2007-2008: results of the Study for Monitoring Antimicrobial Resistance Trends (SMART). |
| AID583091 | Activity of Escherichia coli XL1-Blue wild-type IMP-1 beta-lactamase by spectrophotometer | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | Mutational analysis of VIM-2 reveals an essential determinant for metallo-beta-lactamase stability and folding. |
| AID546421 | Antimicrobial activity against Pseudomonas aeruginosa 12B harboring recombinant pBB-PDC-1 by Etest | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Extended-spectrum cephalosporinases in Pseudomonas aeruginosa. |
| AID554428 | Ratio of MIC for Pseudomonas aeruginosa mutGR1 overexpressing mexXY mutant to Pseudomonas aeruginosa PAO1 | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Efflux unbalance in Pseudomonas aeruginosa isolates from cystic fibrosis patients. |
| AID534609 | Antimicrobial activity against ceftazidime-susceptible Enterobacteriaceae assessed as resistant isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activity of doripenem, a carbapenem for the treatment of challenging infections caused by gram-negative bacteria, against recent clinical isolates from the United States. |
| AID532190 | Antimicrobial activity against aac(6')-Ib-cr-positive Citrobacter freundii TJ15 harboring GyrA T83I, ParC S80I mutant, wild-type GyrB, qnrB genes by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | High prevalence of plasmid-mediated quinolone resistance genes qnr and aac(6')-Ib-cr in clinical isolates of Enterobacteriaceae from nine teaching hospitals in China. |
| AID534610 | Antimicrobial activity against Ceftazidime non-susceptible Enterobacteriaceae assessed as susceptible isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activity of doripenem, a carbapenem for the treatment of challenging infections caused by gram-negative bacteria, against recent clinical isolates from the United States. |
| AID559415 | Antimicrobial activity against Acinetobacter baumannii 3208 expressing multiple-antibiotic resistance gene AbaR5 by Viek 2 system | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | AbaR5, a large multiple-antibiotic resistance region found in Acinetobacter baumannii. |
| AID495802 | Antimicrobial activity against Escherichia coli 138 expressing beta-lactamase VIM-19 by microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Novel VIM metallo-beta-lactamase variant from clinical isolates of Enterobacteriaceae from Algeria. |
| AID529304 | Antimicrobial activity against Acinetobacter baumannii isolate Ac058 expressing beta-lactamase Oxa-58 by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Characterization of the carbapenem-hydrolyzing oxacillinase oxa-58 in an Acinetobacter genospecies 3 clinical isolate. |
| AID326268 | Antibacterial activity against Escherichia coli DH5-alpha by agar dilution technique | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | SCO-1, a novel plasmid-mediated class A beta-lactamase with carbenicillinase characteristics from Escherichia coli. |
| AID546170 | Antimicrobial activity against AmpC overproducing Pseudomonas aeruginosa isolate Pae-beta-10 with PDC-2 variant by Etest | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Extended-spectrum cephalosporinases in Pseudomonas aeruginosa. |
| AID444058 | Volume of distribution at steady state in human | 2010 | Journal of medicinal chemistry, Feb-11, Volume: 53, Issue:3 | Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. |
| AID546406 | Antimicrobial activity against AmpC overproducing Pseudomonas aeruginosa isolate Pae-beta-23 with PDC-5 variant by Etest | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Extended-spectrum cephalosporinases in Pseudomonas aeruginosa. |
| AID285629 | Antimicrobial activity against Pseudomonas aeruginosa 9B2 tracheal isolates from mechanically ventilated chronic respiratory insufficiency patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID530816 | Antibacterial activity against Escherichia coli J53 harboring plasmid-encoded beta-lactamase OXA-48 by Etest method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Plasmid-encoded carbapenem-hydrolyzing beta-lactamase OXA-48 in an imipenem-susceptible Klebsiella pneumoniae strain from Belgium. |
| AID583084 | Activity of Escherichia coli BL21(DE3) VIM-2 W87F mutant beta-lactamase by spectrophotometer | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | Mutational analysis of VIM-2 reveals an essential determinant for metallo-beta-lactamase stability and folding. |
| AID572122 | Antimicrobial activity against ISAba1 linked with the blaOXA-51-type beta-lactamase harboring Acinetobacter baumannii lambda clonal group isolate 28 expressing ampC, ompA, adeM, aadB, aadA1 by Etest method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Correlation of antimicrobial resistance with beta-lactamases, the OmpA-like porin, and efflux pumps in clinical isolates of Acinetobacter baumannii endemic to New York City. |
| AID557799 | Antimicrobial activity against Escherichia coli J53 by CLSI agar dilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | New plasmid-mediated quinolone resistance gene, qnrC, found in a clinical isolate of Proteus mirabilis. |
| AID540219 | Volume of distribution at steady state in monkey after iv administration | 2005 | Journal of pharmaceutical sciences, Jul, Volume: 94, Issue:7 | Extrapolation of human pharmacokinetic parameters from rat, dog, and monkey data: Molecular properties associated with extrapolative success or failure. |
| AID368493 | Activity of Escherichia coli CTX-M-15 assessed as drug hydrolysis by spectrophotometry relative to cephaloridine | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID529902 | Antimicrobial activity against Leptospira interrogans serovar Pomona isolate 12 by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Antimicrobial susceptibilities of geographically diverse clinical human isolates of Leptospira. |
| AID535752 | Antimicrobial activity against hospital-acquired Klebsiella pneumoniae obtained from patient with intra-abdominal infection assessed as susceptible isolates by EUCAST method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Incidence and antimicrobial susceptibility of Escherichia coli and Klebsiella pneumoniae with extended-spectrum beta-lactamases in community- and hospital-associated intra-abdominal infections in Europe: results of the 2008 Study for Monitoring Antimicrob |
| AID283536 | Antibacterial activity against Pseudomonas aeruginosa FE53U with inactivated mexZ and galU genes by microdilution method | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3 | Cumulative effects of several nonenzymatic mechanisms on the resistance of Pseudomonas aeruginosa to aminoglycosides. |
| AID555208 | Antibacterial activity against Acinetobacter genomosp. 3 isolate 69 by Etest method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Genetic variability among ampC genes from acinetobacter genomic species 3. |
| AID564531 | Antimicrobial activity against Escherichia coli TOP10 harboring pADC-11 plasmid with entire blaAmpC gene by Etest method | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | Extended-spectrum cephalosporinase in Acinetobacter baumannii. |
| AID557795 | Antimicrobial activity against Proteus mirabilis 06-489 isolated from infected human urinary tract by CLSI agar dilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | New plasmid-mediated quinolone resistance gene, qnrC, found in a clinical isolate of Proteus mirabilis. |
| AID522381 | Antimicrobial activity against blaKPC-possessing Klebsiella pneumoniae isolates assessed as susceptible isolates by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | In vitro activity of penem-1 in combination with beta-lactams against blaKPC-possessing Klebsiella pneumoniae isolates. |
| AID499122 | Antimicrobial activity against Pseudomonas aeruginosa OC 4354 infected in immunocompromized SKH1 mouse assessed as lesion volume at 1.6 mg/kg/day, sc measured after 48 hrs postinfection (Rvb = 2195 mm3) | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vivo activity of ceftobiprole in murine skin infections due to Staphylococcus aureus and Pseudomonas aeruginosa. |
| AID1373285 | Antimicrobial activity against Escherichia coli expressing beta-lactamase KPC-2 by CLSI broth microdilution method | 2018 | Bioorganic & medicinal chemistry letters, 02-15, Volume: 28, Issue:4 | Optimization of novel monobactams with activity against carbapenem-resistant Enterobacteriaceae - Identification of LYS228. |
| AID546161 | Antimicrobial activity against Pseudomonas aeruginosa isolate Pae-beta-01 with PDC-1 variant by Etest | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Extended-spectrum cephalosporinases in Pseudomonas aeruginosa. |
| AID1373280 | Antimicrobial activity against wild type Escherichia coli by CLSI broth microdilution method | 2018 | Bioorganic & medicinal chemistry letters, 02-15, Volume: 28, Issue:4 | Optimization of novel monobactams with activity against carbapenem-resistant Enterobacteriaceae - Identification of LYS228. |
| AID499118 | Antimicrobial activity against Pseudomonas aeruginosa OC 4351 infected in immunocompromized SKH1 mouse assessed as lesion volume at 1.6 mg/kg/day, sc measured after 48 hrs postinfection (Rvb = 2234 mm3) | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vivo activity of ceftobiprole in murine skin infections due to Staphylococcus aureus and Pseudomonas aeruginosa. |
| AID576320 | Antimicrobial activity against ESBL-positive Klebsiella pneumoniae 31750 harboring porin OmpK36 gene by Etest | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | An ertapenem-resistant extended-spectrum-beta-lactamase-producing Klebsiella pneumoniae clone carries a novel OmpK36 porin variant. |
| AID558783 | Antimicrobial activity against Enterobacter aerogenes assessed as percent susceptible isolates by CLSI method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Emergence of high levels of extended-spectrum-beta-lactamase-producing gram-negative bacilli in the Asia-Pacific region: data from the Study for Monitoring Antimicrobial Resistance Trends (SMART) program, 2007. |
| AID559263 | Antimicrobial activity against Providencia stuartii Ps5 expressing beta-lactamase PER-1 by disk diffusion method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Emergence of extended-spectrum beta-lactamase PER-1 in Proteus vulgaris and Providencia stuartii isolates from Algiers, Algeria. |
| AID521833 | Antimicrobial activity against Streptococcus pneumoniae isolated from non-meningitis patient assessed as percent resistant isolates by CLSI method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Clonal spread of highly beta-lactam-resistant Streptococcus pneumoniae isolates in Taiwan. |
| AID1373302 | Antimicrobial activity against Escherichia coli expressing beta-lactamase TEM-47 by CLSI broth microdilution method | 2018 | Bioorganic & medicinal chemistry letters, 02-15, Volume: 28, Issue:4 | Optimization of novel monobactams with activity against carbapenem-resistant Enterobacteriaceae - Identification of LYS228. |
| AID324862 | Antimicrobial activity against Acinetobacter baumannii A24C after 4 days by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Tigecycline Efflux as a Mechanism for Nonsusceptibility in Acinetobacter baumannii. |
| AID509870 | Antibacterial activity against Acinetobacter baumannii isolate 5191 isolated from human urine | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Acinetobacter baumannii increases tolerance to antibiotics in response to monovalent cations. |
| AID574426 | Antimicrobial activity against Escherichia coli isolate 339T expressing beta-lactamase KPC2 and PFGE cluster 5 isolated from peritoneal fluid of patient by vitek-2 method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Carbapenem-resistant KPC-2-producing Escherichia coli in a Tel Aviv Medical Center, 2005 to 2008. |
| AID285651 | Antimicrobial activity against Pseudomonas aeruginosa 19C5 tracheal isolates from mechanically ventilated chronic respiratory insufficiency patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID546431 | Ratio of Kcat to Km for Pseudomonas aeruginosa PDC-2 by spectrophotometer | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Extended-spectrum cephalosporinases in Pseudomonas aeruginosa. |
| AID556686 | Antimicrobial activity against multidrug resistant Klebsiella pneumoniae isolate 13 by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Occurrence of efflux mechanism and cephalosporinase variant in a population of Enterobacter aerogenes and Klebsiella pneumoniae isolates producing extended-spectrum beta-lactamases. |
| AID528970 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus isolated from ICU patient wound assessed as resistant isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Antimicrobial-resistant pathogens in intensive care units in Canada: results of the Canadian National Intensive Care Unit (CAN-ICU) study, 2005-2006. |
| AID373758 | Antibacterial activity against imipenem-susceptible Acinetobacter baumannii ab1254 by broth dilution method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | An OXA-66/OXA-51-like carbapenemase and possibly an efflux pump are associated with resistance to imipenem in Acinetobacter baumannii. |
| AID567279 | Activity of Acinetobacter baumannii ADC-33 beta-lactamase | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | Extended-spectrum cephalosporinase in Acinetobacter baumannii. |
| AID495906 | Antimicrobial activity in Escherichia coli TOP10 hourbouring recombinant plasmid VIM-4 by Etest | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | VIM-19, a metallo-beta-lactamase with increased carbapenemase activity from Escherichia coli and Klebsiella pneumoniae. |
| AID285602 | Antimicrobial activity against Pseudomonas aeruginosa 2A5 tracheal isolates from mechanically ventilated tuberculosis patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID556682 | Antimicrobial activity against multidrug resistant Klebsiella pneumoniae isolate 9 by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Occurrence of efflux mechanism and cephalosporinase variant in a population of Enterobacter aerogenes and Klebsiella pneumoniae isolates producing extended-spectrum beta-lactamases. |
| AID373055 | Antimicrobial activity against Escherichia coli BL21(DE3) by agar-dilution technique | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Molecular and biochemical characterization of the chromosome-encoded class A beta-lactamase BCL-1 from Bacillus clausii. |
| AID534628 | Antimicrobial activity against Non-ESBL Escherichia coli assessed as intermediate isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activity of doripenem, a carbapenem for the treatment of challenging infections caused by gram-negative bacteria, against recent clinical isolates from the United States. |
| AID534629 | Antimicrobial activity against Non-ESBL Escherichia coli assessed as resistant isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activity of doripenem, a carbapenem for the treatment of challenging infections caused by gram-negative bacteria, against recent clinical isolates from the United States. |
| AID534888 | Antimicrobial activity against Enterobacter cloacae with derepressed AmpC beta-lactamsae assessed as intermediate isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activity of doripenem, a carbapenem for the treatment of challenging infections caused by gram-negative bacteria, against recent clinical isolates from the United States. |
| AID499065 | Antimicrobial activity against carbapenem-resistant Enterobacter aerogenes WH85 deficient in TEM-1, CTX-M-3, ompC/F by CLSI method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Phenotypic and genotypic characterization of Enterobacteriaceae with decreased susceptibility to carbapenems: results from large hospital-based surveillance studies in China. |
| AID535873 | Antimicrobial activity against aac(6')-Ib-cr-positive Citrobacter freundii JN1 harboring GyrA T83I, ParC S80I mutant, wild-type GyrB and qnrA genes by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | High prevalence of plasmid-mediated quinolone resistance genes qnr and aac(6')-Ib-cr in clinical isolates of Enterobacteriaceae from nine teaching hospitals in China. |
| AID565537 | Antibacterial activity against oprD, mexB, mexY and mexD expressing Pseudomonas aeruginosa isolate Paebeta-01 harboring T residue at 105 position in PDC- 1 by Etest method in presence of cloxacillin | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Molecular epidemiology and mechanisms of carbapenem resistance in Pseudomonas aeruginosa. |
| AID612540 | Binding affinity to human PepT2 in SKTP cells | 2011 | Bioorganic & medicinal chemistry, Aug-01, Volume: 19, Issue:15 | Fragmental modeling of hPepT2 and analysis of its binding features by docking studies and pharmacophore mapping. |
| AID524570 | Antimicrobial activity against Shigella sonnei isolate AM22855 by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Identification and characterization of CTX-M-producing Shigella isolates in the United States. |
| AID562472 | Antimicrobial activity against Klebsiella pneumoniae isolate 2641/08 obtained from urine of patient with ischemic cardiomyopathy and several comorbidities by Etest | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | Emergence of Klebsiella pneumoniae ST258 with KPC-2 in Poland. |
| AID576277 | Antimicrobial activity against ESBL-positive Klebsiella pneumoniae 17834 harboring porin OmpK36V mutant gene by Etest | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | An ertapenem-resistant extended-spectrum-beta-lactamase-producing Klebsiella pneumoniae clone carries a novel OmpK36 porin variant. |
| AID499126 | Antimicrobial activity against Pseudomonas aeruginosa OC 4351 infected in immunocompromized SKH1 mouse assessed as log change in bacterial colony forming unit at 1.6 mg/kg/day, sc | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vivo activity of ceftobiprole in murine skin infections due to Staphylococcus aureus and Pseudomonas aeruginosa. |
| AID565709 | Antibacterial activity against mexB, mexY and mexD expressing Pseudomonas aeruginosa isolate Paebeta-14 harboring A residue at 105 position in PDC- 2 and insertion of ISPa27 sequence in OprD gene by Etest method in presence of cloxacillin | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Molecular epidemiology and mechanisms of carbapenem resistance in Pseudomonas aeruginosa. |
| AID369642 | Antibacterial activity against Acinetobacter baumannii C clone by Etest method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Molecular epidemiology of imipenem-resistant Acinetobacter haemolyticus and Acinetobacter baumannii isolates carrying plasmid-mediated OXA-40 from a Portuguese hospital. |
| AID565200 | Antimicrobial activity against Klebsiella pneumoniae isolate A-1760 expressing VIM-1 and KPC-2 genes by microdilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Emerging Klebsiella pneumoniae isolates coproducing KPC-2 and VIM-1 carbapenemases. |
| AID1474167 | Liver toxicity in human assessed as induction of drug-induced liver injury by measuring verified drug-induced liver injury concern status | 2016 | Drug discovery today, Apr, Volume: 21, Issue:4 | DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. |
| AID534303 | Antimicrobial activity against metallo-beta-lactamase-negative Pseudomonas aeruginosa isolate PA483 | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | First survey of metallo-beta-lactamases in clinical isolates of Pseudomonas aeruginosa in a German university hospital. |
| AID372610 | Antibacterial activity against Escherichia coli DH5alpha producing beta-lactamase TEM-1 by microdilution method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | TEM-158 (CMT-9), a new member of the CMT-type extended-spectrum beta-lactamases. |
| AID562575 | Antimicrobial activity against Escherichia coli NO8-1503 harboring blaTEM-168 gene by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | TEM-168, a heretofore laboratory-derived TEM beta-lactamase variant found in an Escherichia coli clinical isolate. |
| AID394693 | Antibacterial activity against beta-lactams resistant Pseudomonas aeruginosa isolate expressing MexAB-OprM pump by macrodilution technique | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10 | Pseudomonas aeruginosa may accumulate drug resistance mechanisms without losing its ability to cause bloodstream infections. |
| AID529658 | Ratio of Kcat to Km for Pseudomonas aeruginosa 166301 beta-lactamase VIM-16 | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | VIM-15 and VIM-16, two new VIM-2-like metallo-beta-lactamases in Pseudomonas aeruginosa isolates from Bulgaria and Germany. |
| AID587728 | Antimicrobial activity against Escherichia coli DH5alpha carrying Pseudomonas aeruginosa strain PS 297 IMP-1-pLBII after 18 hrs by microdilution broth method | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1 | Genetic context and biochemical characterization of the IMP-18 metallo-beta-lactamase identified in a Pseudomonas aeruginosa isolate from the United States. |
| AID521992 | Antimicrobial activity against Escherichia coli isolate J53 harboring pA-1 containing beta-lactamase OXA-48 located within transposon Tn1999 by Etest method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Spread of OXA-48-encoding plasmid in Turkey and beyond. |
| AID529901 | Antimicrobial activity against Leptospira interrogans serovar Icterohaemorrhagiae isolate 10 by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Antimicrobial susceptibilities of geographically diverse clinical human isolates of Leptospira. |
| AID565521 | Antibacterial activity against mexB, mexY and mexD expressing Pseudomonas aeruginosa isolate Paebeta-14 harboring A residue at 105 position in PDC- 2 and insertion of ISPa27 sequence in OprD gene by Etest method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Molecular epidemiology and mechanisms of carbapenem resistance in Pseudomonas aeruginosa. |
| AID340736 | Activity of Chryseobacterium indologenes metallo-beta-lactamase IND-5 expressed in Escherichia coli BL21(DE3) assessed as substrate hydrolysis | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8 | Identification and characterization of a new metallo-beta-lactamase, IND-5, from a clinical isolate of Chryseobacterium indologenes. |
| AID576265 | Antimicrobial activity against ESBL-positive Klebsiella pneumoniae 19039 harboring porin OmpK36V mutant gene by Etest | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | An ertapenem-resistant extended-spectrum-beta-lactamase-producing Klebsiella pneumoniae clone carries a novel OmpK36 porin variant. |
| AID368495 | Ratio of Kcat to Km of Escherichia coli CTX-M-15 assessed as drug hydrolysis by spectrophotometry relative to cephaloridine | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID368726 | Activity of Serratia marcescens AmpC assessed as drug hydrolysis by spectrophotometry relative to cephaloridine | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID545455 | Antimicrobial activity against Pseudomonas aeruginosa assessed as percent susceptible isolates by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Susceptibility of gram-negative pathogens isolated from patients with complicated intra-abdominal infections in the United States, 2007-2008: results of the Study for Monitoring Antimicrobial Resistance Trends (SMART). |
| AID524435 | Antimicrobial activity against Shigella isolate DH-13291 by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Identification and characterization of CTX-M-producing Shigella isolates in the United States. |
| AID373759 | Antibacterial activity against imipenem-susceptible Acinetobacter baumannii ab1316 by broth dilution method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | An OXA-66/OXA-51-like carbapenemase and possibly an efflux pump are associated with resistance to imipenem in Acinetobacter baumannii. |
| AID573345 | Antibacterial activity against ceftazidime-nonsusceptible Citrobacter freundii assessed as resistant isolates by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID528974 | Antimicrobial activity against methicillin-susceptible Staphylococcus aureus isolated from ICU patient respiratory tract assessed as resistant isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Antimicrobial-resistant pathogens in intensive care units in Canada: results of the Canadian National Intensive Care Unit (CAN-ICU) study, 2005-2006. |
| AID576065 | Antimicrobial activity against ESBL-positive Klebsiella pneumoniae 69928 harboring porin OmpK36V mutant gene by Etest | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | An ertapenem-resistant extended-spectrum-beta-lactamase-producing Klebsiella pneumoniae clone carries a novel OmpK36 porin variant. |
| AID587732 | Activity of Pseudomonas aeruginosa strain PS 297 metallo-beta-lactamase IMP-1 expressed in Escherichia coli BL21(DE3) assessed as substrate hydrolysis using 100 uM nitrocefin | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1 | Genetic context and biochemical characterization of the IMP-18 metallo-beta-lactamase identified in a Pseudomonas aeruginosa isolate from the United States. |
| AID405638 | Inhibition of bocillin FL binding to Escherichia coli MC4100 penicillin-binding protein 4 | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | Binding of ceftobiprole and comparators to the penicillin-binding proteins of Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Streptococcus pneumoniae. |
| AID511580 | Antimicrobial activity against beta-lactam resistant Pseudomonas aeruginosa PAO1 deficient in ampD, ampDh3 and ampDh3 gene selected in vitro after antipseudomonal treatment of intensive care unit patient by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Activity of a new cephalosporin, CXA-101 (FR264205), against beta-lactam-resistant Pseudomonas aeruginosa mutants selected in vitro and after antipseudomonal treatment of intensive care unit patients. |
| AID535635 | Antimicrobial activity against Group B streptococcus serotype VI R5 harboring F395L, V405A, R433H, H438Y, and G648A mutations in PBP 2X and T567I mutation in PBP 2B by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | Genetic heterogeneity in pbp genes among clinically isolated group B Streptococci with reduced penicillin susceptibility. |
| AID681718 | TP_TRANSPORTER: inhibition of Carnitine uptake (Carnitine: 0.02 uM, Cefepime: 2500 uM) in OCTN2-expressing HeLa cells | 2000 | The Journal of biological chemistry, Jan-21, Volume: 275, Issue:3 | beta-lactam antibiotics as substrates for OCTN2, an organic cation/carnitine transporter. |
| AID495516 | Antibacterial activity against multidrug-resistant Acinetobacter baumannii AYE by antimicrobial susceptibility assay | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Screening and quantification of the expression of antibiotic resistance genes in Acinetobacter baumannii with a microarray. |
| AID554991 | Antibacterial activity against Acinetobacter genomosp. 3 isolate 67 by Etest method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Genetic variability among ampC genes from acinetobacter genomic species 3. |
| AID535694 | Antimicrobial activity against Azide-resistant Escherichia coli J53 transconjugant harboring Escherichia coli DH5alpha-5825 qnrB2 gene by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Detection of the pandemic O25-ST131 human virulent Escherichia coli CTX-M-15-producing clone harboring the qnrB2 and aac(6')-Ib-cr genes in a dog. |
| AID554426 | Ratio of MIC for Pseudomonas aeruginosa FE60 transformed with pAGH97 carrying mexXY F1018L mutant to Pseudomonas aeruginosa PAO1 | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Efflux unbalance in Pseudomonas aeruginosa isolates from cystic fibrosis patients. |
| AID571886 | Antimicrobial activity against ISAba1 linked with the blaOXA-51-type beta-lactamase harboring Acinetobacter baumannii alpha clonal group isolate 7 expressing ampC, ompA, adeB, adeM, blaSHV-5 by Etest method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Correlation of antimicrobial resistance with beta-lactamases, the OmpA-like porin, and efflux pumps in clinical isolates of Acinetobacter baumannii endemic to New York City. |
| AID549334 | Antimicrobial activity against Escherichia coli isolate 100 harboring bla CTX-M-3a gene by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | blaCTX-M genes in escherichia coli strains from Croatian Hospitals are located in new (blaCTX-M-3a) and widely spread (blaCTX-M-3a and blaCTX-M-15) genetic structures. |
| AID560070 | Antimicrobial activity against Klebsiella pneumoniae isolate 5436 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | In vitro activity of ceftaroline alone and in combination against clinical isolates of resistant gram-negative pathogens, including beta-lactamase-producing Enterobacteriaceae and Pseudomonas aeruginosa. |
| AID529653 | Antimicrobial activity against Escherichia coli DH5alpha by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | VIM-15 and VIM-16, two new VIM-2-like metallo-beta-lactamases in Pseudomonas aeruginosa isolates from Bulgaria and Germany. |
| AID534301 | Antimicrobial activity against metallo-beta-lactamase-negative Pseudomonas aeruginosa isolate PA460 | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | First survey of metallo-beta-lactamases in clinical isolates of Pseudomonas aeruginosa in a German university hospital. |
| AID556687 | Antimicrobial activity against multidrug resistant Klebsiella pneumoniae isolate 14 by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Occurrence of efflux mechanism and cephalosporinase variant in a population of Enterobacter aerogenes and Klebsiella pneumoniae isolates producing extended-spectrum beta-lactamases. |
| AID533877 | Antibacterial activity against amoxicillin-intermediate Streptococcus pneumoniae assessed as percent susceptible isolates by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | In vitro activity of ceftaroline against Streptococcus pneumoniae isolates exhibiting resistance to penicillin, amoxicillin, and cefotaxime. |
| AID285659 | Antimicrobial activity against Pseudomonas aeruginosa 19E9 tracheal isolates from mechanically ventilated chronic respiratory insufficiency patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID556672 | Antimicrobial activity against multidrug resistant Enterobacter aerogenes isolate 27 by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Occurrence of efflux mechanism and cephalosporinase variant in a population of Enterobacter aerogenes and Klebsiella pneumoniae isolates producing extended-spectrum beta-lactamases. |
| AID544489 | Antibacterial activity against Enterobacter cancerogenus E624 harboring beta-lactamase KPC-4 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Phenotypic and enzymatic comparative analysis of the novel KPC variant KPC-5 and its evolutionary variants, KPC-2 and KPC-4. |
| AID499133 | Antimicrobial activity against Pseudomonas aeruginosa OC 4354 infected in immunocompromized SKH1 mouse assessed as log change in bacterial colony forming unit at 100 mg/kg/day, sc | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vivo activity of ceftobiprole in murine skin infections due to Staphylococcus aureus and Pseudomonas aeruginosa. |
| AID368517 | Ratio of Kcat to Km of Pseudomonas aeruginosa VIM2 assessed as drug hydrolysis by spectrophotometry | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID565283 | Antibacterial activity against Pseudomonas aeruginosa PAO1 harboring plasmid pA1 by Etest method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Nosocomial spread of colistin-only-sensitive sequence type 235 Pseudomonas aeruginosa isolates producing the extended-spectrum beta-lactamases GES-1 and GES-5 in Spain. |
| AID424858 | Antimicrobial activity against Pseudomonas aeruginosa GY3 producing blaVIM-2 by E-test | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Molecular epidemiology and mechanisms of carbapenem resistance in Pseudomonas aeruginosa isolates from Spanish hospitals. |
| AID444051 | Total clearance in human | 2010 | Journal of medicinal chemistry, Feb-11, Volume: 53, Issue:3 | Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. |
| AID534607 | Antimicrobial activity against ceftazidime-susceptible Enterobacteriaceae assessed as susceptible isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activity of doripenem, a carbapenem for the treatment of challenging infections caused by gram-negative bacteria, against recent clinical isolates from the United States. |
| AID547522 | Antimicrobial activity against Streptococcus constellatus obtained from patient with cystic fibrosis assessed as non-susceptible isolates grown on mueller-Hinton blood agar at 30 ug/ml after 24 hrs at 37 degC by disk diffusion method in presence of 5% def | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Macrolide and clindamycin resistance in Streptococcus milleri group isolates from the airways of cystic fibrosis patients. |
| AID498815 | Antimicrobial activity against Klebsiella pneumoniae FZ47T expressing IMP-8, TEM-1, CTX-M-14, qnrB2, aac(6')-Ib by CLSI method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Phenotypic and genotypic characterization of Enterobacteriaceae with decreased susceptibility to carbapenems: results from large hospital-based surveillance studies in China. |
| AID1373292 | Antimicrobial activity against Escherichia coli expressing beta-lactamase PER-4 by CLSI broth microdilution method | 2018 | Bioorganic & medicinal chemistry letters, 02-15, Volume: 28, Issue:4 | Optimization of novel monobactams with activity against carbapenem-resistant Enterobacteriaceae - Identification of LYS228. |
| AID405080 | Antimicrobial activity against Citrobacter freundii 33587 isolate by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | Biochemical characterization of PER-2 and genetic environment of blaPER-2. |
| AID1139545 | Antibacterial activity against Escherichia coli DH5alpha expressing beta-lactamase OXA-24/40 by CLSI broth microdilution method | 2014 | Journal of medicinal chemistry, May-08, Volume: 57, Issue:9 | Siderophore receptor-mediated uptake of lactivicin analogues in gram-negative bacteria. |
| AID532389 | Antibacterial activity against VIM-1 producing Enterobacter cloacae isolate TO-16X-51 by Etest method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | First countrywide survey of acquired metallo-beta-lactamases in gram-negative pathogens in Italy. |
| AID582974 | Antimicrobial activity against dacB::lox and nagZ::lox gene-deficient Pseudomonas aeruginosa PAO1 by Etest method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | NagZ inactivation prevents and reverts beta-lactam resistance, driven by AmpD and PBP 4 mutations, in Pseudomonas aeruginosa. |
| AID405790 | Inhibition of bocillin FL binding to Pseudomonas aeruginosa PAO1 penicillin-binding protein 3 | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | Binding of ceftobiprole and comparators to the penicillin-binding proteins of Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Streptococcus pneumoniae. |
| AID565508 | Antibacterial activity against mexB, mexY and mexD expressing Pseudomonas aeruginosa isolate Paebeta-26 harboring T residue at 105 position in PDC- 6 and polymorphic OprD gene by Etest method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Molecular epidemiology and mechanisms of carbapenem resistance in Pseudomonas aeruginosa. |
| AID562736 | Antimicrobial activity against Klebsiella pneumoniae AH24-270 expressing blaCTX-M-71 gene by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | New variant of CTX-M-type extended-spectrum beta-lactamases, CTX-M-71, with a Gly238Cys substitution in a Klebsiella pneumoniae isolate from Bulgaria. |
| AID495655 | Antimicrobial activity against Pseudomonas aeruginosa 51170 expressing beta-lactamase BEL-1 by solid agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | BEL-2, an extended-spectrum beta-lactamase with increased activity toward expanded-spectrum cephalosporins in Pseudomonas aeruginosa. |
| AID546419 | Antimicrobial activity against Pseudomonas aeruginosa KG2505a harboring recombinant pBB-PDC-4 by Etest | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Extended-spectrum cephalosporinases in Pseudomonas aeruginosa. |
| AID533759 | Antibacterial activity against OXA-10, PSE-1, VIM-2 and PER-1 producing Pseudomonas aeruginosa isolate P22 exhibiting PFGE F pattern by 2-fold agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | Nationwide investigation of extended-spectrum beta-lactamases, metallo-beta-lactamases, and extended-spectrum oxacillinases produced by ceftazidime-resistant Pseudomonas aeruginosa strains in France. |
| AID564460 | Antimicrobial activity against Pseudomonas aeruginosa isolate 1006 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | In vivo efficacy of 1- and 2-gram human simulated prolonged infusions of doripenem against Pseudomonas aeruginosa. |
| AID1559402 | AUC (infinity) in mouse at 10 mg/kg, iv after 1 to 6 hrs by LC-MS/MS analysis | 2020 | Journal of medicinal chemistry, 03-26, Volume: 63, Issue:6 | Discovery of Taniborbactam (VNRX-5133): A Broad-Spectrum Serine- and Metallo-β-lactamase Inhibitor for Carbapenem-Resistant Bacterial Infections. |
| AID556674 | Antimicrobial activity against multidrug resistant Klebsiella pneumoniae isolate 1 by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Occurrence of efflux mechanism and cephalosporinase variant in a population of Enterobacter aerogenes and Klebsiella pneumoniae isolates producing extended-spectrum beta-lactamases. |
| AID540216 | Clearance in dog after iv administration | 2005 | Journal of pharmaceutical sciences, Jul, Volume: 94, Issue:7 | Extrapolation of human pharmacokinetic parameters from rat, dog, and monkey data: Molecular properties associated with extrapolative success or failure. |
| AID583017 | Antimicrobial activity against OmpC/OmpF porin deficient Escherichia coli HB4 transformed with Escherichia coli ECB-1 plasmid carrying ACC-1 by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Phenotypic and biochemical comparison of the carbapenem-hydrolyzing activities of five plasmid-borne AmpC β-lactamases. |
| AID534771 | Antimicrobial activity against Acinetobacter baumannii-calcoaceticus obtained from war-wounded patient assessed as susceptible isolates | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | In vitro activity of the aminoglycoside antibiotic arbekacin against Acinetobacter baumannii-calcoaceticus isolated from war-wounded patients at Walter Reed Army Medical Center. |
| AID565534 | Antibacterial activity against oprD, mexB, mexY and mexD expressing Pseudomonas aeruginosa isolate Paebeta-01 harboring T residue at 105 position in PDC- 1 by Etest method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Molecular epidemiology and mechanisms of carbapenem resistance in Pseudomonas aeruginosa. |
| AID368506 | Activity of Escherichia coli KPC2 assessed as drug hydrolysis by spectrophotometry relative to cephaloridine | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID660261 | Ratio of MIC for wild type Escherichia coli JC7623 to MIC for acrAB-deficient Escherichia coli JZM120 | 2012 | European journal of medicinal chemistry, Jun, Volume: 52 | Computational analysis of structure-based interactions and ligand properties can predict efflux effects on antibiotics. |
| AID573377 | Antibacterial activity against imipenem-susceptible Acinetobacter assessed as susceptible isolates by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID520800 | Antimicrobial activity against CTX-M-2 producing Klebsiella pneumoniae with PFGE pulsotype H by Etest | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Multiclonal outbreak of Klebsiella pneumoniae producing extended-spectrum beta-lactamase CTX-M-2 and novel variant CTX-M-59 in a neonatal intensive care unit in Brazil. |
| AID562737 | Antimicrobial activity against Escherichia coli K-12 transconjugant harboring blaCTX-M-71 gene by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | New variant of CTX-M-type extended-spectrum beta-lactamases, CTX-M-71, with a Gly238Cys substitution in a Klebsiella pneumoniae isolate from Bulgaria. |
| AID583029 | Antimicrobial activity against Escherichia coli TOP10 transformed with Escherichia coli DH10B plasmid carrying DHA-1 by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Phenotypic and biochemical comparison of the carbapenem-hydrolyzing activities of five plasmid-borne AmpC β-lactamases. |
| AID564219 | Antimicrobial activity against Acinetobacter baumannii ATCC 19606 by Etest method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | OXA-143, a novel carbapenem-hydrolyzing class D beta-lactamase in Acinetobacter baumannii. |
| AID532407 | Antibacterial activity against VIM-2 producing Pseudomonas aeruginosa clone B2 isolate VA-06X-20 by Etest method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | First countrywide survey of acquired metallo-beta-lactamases in gram-negative pathogens in Italy. |
| AID544963 | Antimicrobial activity against Klebsiella pneumoniae expressing extended-spectrum beta-lactamase and beta-lactamase AmpC by Etest | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Characterization and sequence analysis of extended-spectrum-{beta}-lactamase-encoding genes from Escherichia coli, Klebsiella pneumoniae, and Proteus mirabilis isolates collected during tigecycline phase 3 clinical trials. |
| AID373024 | Antimicrobial activity against imipenem and meropenem-resistant Acinetobacter baumannii isolate PU4A1 by CLSI agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Molecular epidemiology of clinical isolates of carbapenem-resistant Acinetobacter spp. from Chinese hospitals. |
| AID535654 | Antimicrobial activity against aac(6')-Ib-cr-negative Enterobacter cloacae FJ61 harboring GyrA S83I, GyrA D87A, ParC S80I mutant, wild-type GyrB and qnrS genes by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | High prevalence of plasmid-mediated quinolone resistance genes qnr and aac(6')-Ib-cr in clinical isolates of Enterobacteriaceae from nine teaching hospitals in China. |
| AID373208 | Antimicrobial activity against Bacillus clausii DSM 8716 by agar-dilution technique | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Molecular and biochemical characterization of the chromosome-encoded class A beta-lactamase BCL-1 from Bacillus clausii. |
| AID522020 | Antimicrobial activity against Escherichia coli isolate J53 harboring pEnc1 containing beta-lactamase OXA-48 located within transposon Tn1999 by Etest method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Spread of OXA-48-encoding plasmid in Turkey and beyond. |
| AID521346 | Antimicrobial activity against Streptococcus pneumoniae isolate 2904 obtained from blood of patient | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Highly variable penicillin resistance determinants PBP 2x, PBP 2b, and PBP 1a in isolates of two Streptococcus pneumoniae clonal groups, Poland 23F-16 and Poland 6B-20. |
| AID535062 | Antimicrobial activity against Acinetobacter genomic species 13TU ATCC 17903 harboring pOXA-58-5 plasmid by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | Contribution of a plasmid-borne blaOXA-58 gene with its hybrid promoter provided by IS1006 and an ISAba3-like element to beta-lactam resistance in acinetobacter genomic species 13TU. |
| AID405791 | Inhibition of bocillin FL binding to Pseudomonas aeruginosa PAO1 penicillin-binding protein 4 | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | Binding of ceftobiprole and comparators to the penicillin-binding proteins of Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Streptococcus pneumoniae. |
| AID546414 | Antimicrobial activity against Pseudomonas aeruginosa isolate Pae-beta-31 with PDC-9 variant by Etest | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Extended-spectrum cephalosporinases in Pseudomonas aeruginosa. |
| AID428267 | Antimicrobial activity against carbapenemase producing Enterobacteriaceae assessed as susceptible isolates by CLSI breakpoint assay | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | Antimicrobial activities of tigecycline and other broad-spectrum antimicrobials tested against serine carbapenemase- and metallo-beta-lactamase-producing Enterobacteriaceae: report from the SENTRY Antimicrobial Surveillance Program. |
| AID529572 | Antimicrobial activity against Erwinia carotovora subsp. atroseptica DSM 30184 after 24 hrs by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Functional diversity among metallo-beta-lactamases: characterization of the CAR-1 enzyme of Erwinia carotovora. |
| AID499132 | Antimicrobial activity against Pseudomonas aeruginosa OC 4354 infected in immunocompromized SKH1 mouse assessed as log change in bacterial colony forming unit at 25 mg/kg/day, sc | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vivo activity of ceftobiprole in murine skin infections due to Staphylococcus aureus and Pseudomonas aeruginosa. |
| AID528739 | Antimicrobial activity against penicillin-resistant Streptococcus agalactiae B516 by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | First molecular characterization of group B streptococci with reduced penicillin susceptibility. |
| AID283531 | Antibacterial activity against Pseudomonas aeruginosa FE49 with inactivated galU gene by microdilution method | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3 | Cumulative effects of several nonenzymatic mechanisms on the resistance of Pseudomonas aeruginosa to aminoglycosides. |
| AID556688 | Antimicrobial activity against multidrug resistant Klebsiella pneumoniae isolate 15 by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Occurrence of efflux mechanism and cephalosporinase variant in a population of Enterobacter aerogenes and Klebsiella pneumoniae isolates producing extended-spectrum beta-lactamases. |
| AID534194 | Antimicrobial activity against Pseudomonas putida expressing beta-lactamase KPC-2 and SHV-12 obtained from criticall ill liver transplant recipient by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | KPC-2-producing Enterobacter cloacae and pseudomonas putida coinfection in a liver transplant recipient. |
| AID373774 | Antibacterial activity against imipenem-resistant Acinetobacter baumannii abh39 by broth dilution method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | An OXA-66/OXA-51-like carbapenemase and possibly an efflux pump are associated with resistance to imipenem in Acinetobacter baumannii. |
| AID524743 | Antimicrobial activity against Escherichia coli GB20 harboring D240G mutation in beta lactamase CTX-M-10 by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Mutational events in cefotaximase extended-spectrum beta-lactamases of the CTX-M-1 cluster involved in ceftazidime resistance. |
| AID498807 | Antimicrobial activity against Klebsiella pneumoniae ZJ71T expressing KPC-2 by CLSI method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Phenotypic and genotypic characterization of Enterobacteriaceae with decreased susceptibility to carbapenems: results from large hospital-based surveillance studies in China. |
| AID562340 | Ratio of Kcat to Km for Chryseobacterium indologenes 597 metallo-beta-lactamase IND-2 expressed in Escherichia coli DH5alpha by Michaelis-Menten equation | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | IND-6, a highly divergent IND-type metallo-beta-lactamase from Chryseobacterium indologenes strain 597 isolated in Burkina Faso. |
| AID556683 | Antimicrobial activity against multidrug resistant Klebsiella pneumoniae isolate 10 by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Occurrence of efflux mechanism and cephalosporinase variant in a population of Enterobacter aerogenes and Klebsiella pneumoniae isolates producing extended-spectrum beta-lactamases. |
| AID508297 | Inhibition of PBP3 in penicillin-resistant Enterococcus faecium D63r membranes assessed as inhibition of fluorescent ampicillin binding after 20 mins at 37 degC | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2 | Interaction of ceftobiprole with the low-affinity PBP 5 of Enterococcus faecium. |
| AID545443 | Antimicrobial activity against extended-spectrum beta-lactamase-positive Klebsiella pneumoniae assessed as percent susceptible isolates by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Susceptibility of gram-negative pathogens isolated from patients with complicated intra-abdominal infections in the United States, 2007-2008: results of the Study for Monitoring Antimicrobial Resistance Trends (SMART). |
| AID341593 | Antibacterial activity against carbapenem-resistant Klebsiella pneumoniae 469 isolate producing KPC2, OXA4 and CTX-M-10 carbapenemases | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8 | Emergence of KPC-2 and KPC-3 in carbapenem-resistant Klebsiella pneumoniae strains in an Israeli hospital. |
| AID555220 | Antibacterial activity against Escherichia coli DH5alpha carrying ampC gene of Acinetobacter genomosp. 3 isolate 103 by Etest method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Genetic variability among ampC genes from acinetobacter genomic species 3. |
| AID285601 | Antimicrobial activity against Pseudomonas aeruginosa 2A3 tracheal isolates from mechanically ventilated tuberculosis patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID556653 | Antimicrobial activity against multidrug resistant Enterobacter aerogenes isolate 8 by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Occurrence of efflux mechanism and cephalosporinase variant in a population of Enterobacter aerogenes and Klebsiella pneumoniae isolates producing extended-spectrum beta-lactamases. |
| AID567311 | Antimicrobial activity against SHV-12 ESBL producing Pseudomonas aeruginosa isolate 2202 isolated from burn patient by broth microdilution method in presence of beta-lactamase inhibitor clavulanic acid | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Acquisition of a transposon encoding extended-spectrum beta-lactamase SHV-12 by Pseudomonas aeruginosa isolates during the clinical course of a burn patient. |
| AID521427 | Antibacterial activity against Stenotrophomonas maltophilia isolate KJ deficient in L2 beta lactamase gene by Etest | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Induction of L1 and L2 beta-lactamases of Stenotrophomonas maltophilia. |
| AID1373321 | Antimicrobial activity against Escherichia coli expressing beta-lactamase Oxa-146 by CLSI broth microdilution method | 2018 | Bioorganic & medicinal chemistry letters, 02-15, Volume: 28, Issue:4 | Optimization of novel monobactams with activity against carbapenem-resistant Enterobacteriaceae - Identification of LYS228. |
| AID583640 | Cmin in febrile neutropenic patient with GFR of >40 to 70 ml/min at 2 g administered as 30 mins infusion every 8 hrs measured after 4 days by HPLC analysis | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | High cefepime plasma concentrations and neurological toxicity in febrile neutropenic patients with mild impairment of renal function. |
| AID499130 | Antimicrobial activity against Pseudomonas aeruginosa OC 4354 infected in immunocompromized SKH1 mouse assessed as log change in bacterial colony forming unit at 1.6 mg/kg/day, sc | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vivo activity of ceftobiprole in murine skin infections due to Staphylococcus aureus and Pseudomonas aeruginosa. |
| AID510511 | Antibacterial activity against Acinetobacter calcoaceticus/baumannii complex isolate N2AC9-19 expressing KPC beta lactamase | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Detection of KPC in Acinetobacter spp. in Puerto Rico. |
| AID523889 | Antimicrobial activity against Acinetobacter baumannii 6AB15 harboring ISAba1-blaOXA-23 and blaOXA-66 gene by Etest | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Genetic basis of multidrug resistance in Acinetobacter clinical isolates in Taiwan. |
| AID368480 | Antibacterial activity against Enterobacter cloacae 908R producing beta lactamase AmpC by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID528847 | Antimicrobial activity against methicillin-resistant Staphylococcus epidermidis isolated from ICU patient blood assessed as resistant isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Antimicrobial-resistant pathogens in intensive care units in Canada: results of the Canadian National Intensive Care Unit (CAN-ICU) study, 2005-2006. |
| AID565719 | Antibacterial activity against oprD, mexB, mexY and mexD expressing Pseudomonas aeruginosa isolate Paebeta-24 harboring A residue at 105 position in PDC- 5 by Etest method in presence of cloxacillin | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Molecular epidemiology and mechanisms of carbapenem resistance in Pseudomonas aeruginosa. |
| AID424855 | Antibacterial activity in Proteus sp. infected patient assessed as mortality after 28 days | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Failure of current cefepime breakpoints to predict clinical outcomes of bacteremia caused by gram-negative organisms. |
| AID285678 | Antimicrobial activity against Pseudomonas aeruginosa 29G6 tracheal isolates from mechanically ventilated chronic respiratory insufficiency patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID565519 | Antibacterial activity against oprD, mexB, mexY and mexD expressing Pseudomonas aeruginosa isolate Paebeta-16 harboring A residue at 105 position in PDC- 3 by Etest method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Molecular epidemiology and mechanisms of carbapenem resistance in Pseudomonas aeruginosa. |
| AID499119 | Antimicrobial activity against Pseudomonas aeruginosa OC 4351 infected in immunocompromized SKH1 mouse assessed as lesion volume at 6.2 mg/kg/day, sc measured after 48 hrs postinfection (Rvb = 2234 mm3) | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vivo activity of ceftobiprole in murine skin infections due to Staphylococcus aureus and Pseudomonas aeruginosa. |
| AID524926 | Antimicrobial activity against Escherichia coli MI1443 harboring A77V and P167S mutations in beta lactamase CTX-M-10 by E-test | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Mutational events in cefotaximase extended-spectrum beta-lactamases of the CTX-M-1 cluster involved in ceftazidime resistance. |
| AID368324 | Antibacterial activity against Serratia marcescens 7554 producing beta lactamase SME3 by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID522013 | Antimicrobial activity against Klebsiella pneumoniae isolate KpBEL expressing beta-lactamase OXA-48 by Etest method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Spread of OXA-48-encoding plasmid in Turkey and beyond. |
| AID522019 | Antimicrobial activity against Enterobacter cloacae isolate 1 expressing beta-lactamase OXA-48 and SHV-5 by Etest method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Spread of OXA-48-encoding plasmid in Turkey and beyond. |
| AID554437 | Ratio of MIC for Pseudomonas aeruginosa 2729 to MIC for Pseudomonas aeruginosa PAO1 | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Efflux unbalance in Pseudomonas aeruginosa isolates from cystic fibrosis patients. |
| AID521356 | Antimicrobial activity against Streptococcus pneumoniae isolate 2907 obtained from sinusitis of patient | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Highly variable penicillin resistance determinants PBP 2x, PBP 2b, and PBP 1a in isolates of two Streptococcus pneumoniae clonal groups, Poland 23F-16 and Poland 6B-20. |
| AID499059 | Antimicrobial activity against carbapenem-resistant Enterobacter aerogenes PU41 deficient in CTX-M-14, DHA-1, qnrS1, ompC DEc, ompF by CLSI method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Phenotypic and genotypic characterization of Enterobacteriaceae with decreased susceptibility to carbapenems: results from large hospital-based surveillance studies in China. |
| AID368491 | Ratio of Kcat to Km of Klebsiella pneumoniae SHV1 assessed as drug hydrolysis by spectrophotometry relative to cephaloridine | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID561670 | Antimicrobial activity against Pseudomonas aeruginosa isolate OC16827 harboring plasmid MexZ expressing mexXY gene by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Effect of MexXY overexpression on ceftobiprole susceptibility in Pseudomonas aeruginosa. |
| AID524938 | Antimicrobial activity against Escherichia coli MI1443 harboring V27A, Q38R, P167S and D240G mutations in beta lactamase CTX-M-3 by E-test | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Mutational events in cefotaximase extended-spectrum beta-lactamases of the CTX-M-1 cluster involved in ceftazidime resistance. |
| AID535646 | Antimicrobial activity against Group B Streptococcus serotype III NEM 316 by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | Genetic heterogeneity in pbp genes among clinically isolated group B Streptococci with reduced penicillin susceptibility. |
| AID573192 | Antimicrobial activity against mexD::lox-deficient Pseudomonas aeruginosa PAOMxD biofilm by Etest method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Azithromycin in Pseudomonas aeruginosa biofilms: bactericidal activity and selection of nfxB mutants. |
| AID326267 | Antibacterial activity against Escherichia coli DH5-alpha carrying pSCO1 encoding SCO1 by agar dilution technique | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | SCO-1, a novel plasmid-mediated class A beta-lactamase with carbenicillinase characteristics from Escherichia coli. |
| AID394691 | Antibacterial activity against beta-lactams resistant Pseudomonas aeruginosa isolate expressing PSE-1 by macrodilution technique | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10 | Pseudomonas aeruginosa may accumulate drug resistance mechanisms without losing its ability to cause bloodstream infections. |
| AID498844 | Antimicrobial activity against Klebsiella pneumoniae XJ81T expressing TEM-1, SHV-12, aac(6')-Ib by CLSI method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Phenotypic and genotypic characterization of Enterobacteriaceae with decreased susceptibility to carbapenems: results from large hospital-based surveillance studies in China. |
| AID495805 | Antimicrobial activity against Klebsiella pneumoniae 6828 strain expressing beta-lactamase VIM-19 by microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Novel VIM metallo-beta-lactamase variant from clinical isolates of Enterobacteriaceae from Algeria. |
| AID1318927 | Antibacterial activity against multidrug-resistant/tobramycin-susceptible Pseudomonas aeruginosa isolate 86053 | 2016 | Journal of medicinal chemistry, 09-22, Volume: 59, Issue:18 | Hybrid Antibiotic Overcomes Resistance in P. aeruginosa by Enhancing Outer Membrane Penetration and Reducing Efflux. |
| AID530330 | Antimicrobial activity against Escherichia coli XL1-Blue by Etest method | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Characterization of the new metallo-beta-lactamase VIM-13 and its integron-borne gene from a Pseudomonas aeruginosa clinical isolate in Spain. |
| AID534649 | Antimicrobial activity against Non-ESBL Klebsiella pneumoniae assessed as resistant isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activity of doripenem, a carbapenem for the treatment of challenging infections caused by gram-negative bacteria, against recent clinical isolates from the United States. |
| AID405091 | Antimicrobial activity against non-integron carrying Enterobacteriaceae assessed as percent resistant isolates | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | Enterobacteriaceae bloodstream infections: presence of integrons, risk factors, and outcome. |
| AID520973 | Antibacterial activity against Klebsiella pneumoniae KN2303 by Etest method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Genetic structures at the origin of acquisition of the beta-lactamase bla KPC gene. |
| AID565725 | Antibacterial activity against oprD, mexB, mexY and mexD expressing Pseudomonas aeruginosa isolate Paebeta-30 harboring A residue at 105 position in PDC- 8 by Etest method in presence of cloxacillin | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Molecular epidemiology and mechanisms of carbapenem resistance in Pseudomonas aeruginosa. |
| AID394682 | Antibacterial activity against Pseudomonas aeruginosa clinical isolates assessed as resistant rate by macrodilution technique | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10 | Pseudomonas aeruginosa may accumulate drug resistance mechanisms without losing its ability to cause bloodstream infections. |
| AID546425 | Antimicrobial activity against Pseudomonas aeruginosa 12B harboring recombinant pBB-PDC-5 by Etest | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Extended-spectrum cephalosporinases in Pseudomonas aeruginosa. |
| AID530323 | Antimicrobial activity against Pseudomonas aeruginosa PAO1 harboring pUCP carrying VIM-1 gene by Etest method | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Characterization of the new metallo-beta-lactamase VIM-13 and its integron-borne gene from a Pseudomonas aeruginosa clinical isolate in Spain. |
| AID559273 | Antimicrobial activity against Providencia stuartii Ps5 expressing beta-lactamase PER-1 by Etest | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Emergence of extended-spectrum beta-lactamase PER-1 in Proteus vulgaris and Providencia stuartii isolates from Algiers, Algeria. |
| AID519743 | Antibacterial activity against Klebsiella pneumoniae INSRA1229 harboring SHV-72 Ile8Phe, Ala146Val, and Lys234Arg mutations by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | The Lys234Arg substitution in the enzyme SHV-72 is a determinant for resistance to clavulanic acid inhibition. |
| AID424863 | Antimicrobial activity against carbapenem-resistant Pseudomonas aeruginosa clinical isolate assessed as resistant isolates | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Molecular epidemiology and mechanisms of carbapenem resistance in Pseudomonas aeruginosa isolates from Spanish hospitals. |
| AID565710 | Antibacterial activity against mexB, mexY and mexD expressing Pseudomonas aeruginosa isolate Paebeta-15 harboring A residue at 105 position in PDC- 2 and polymorphic OprD gene by Etest method in presence of cloxacillin | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Molecular epidemiology and mechanisms of carbapenem resistance in Pseudomonas aeruginosa. |
| AID523892 | Antimicrobial activity against Acinetobacter baumannii ATCC 15151 harboring ISAba1-blaOXA-23 gene by Etest | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Genetic basis of multidrug resistance in Acinetobacter clinical isolates in Taiwan. |
| AID285521 | Antibacterial activity against Pseudomonas aeruginosa after 24 hrs by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | In vitro and in vivo antibacterial activities of heteroaryl isothiazolones against resistant gram-positive pathogens. |
| AID394489 | Activity of Hafnia alvei beta-lactamase ACC-1 | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10 | Plasmid-encoded ACC-4, an extended-spectrum cephalosporinase variant from Escherichia coli. |
| AID577650 | Antimicrobial activity against Escherichia coli isolate 329T expressing beta-lactamase KPC2 and PFGE cluster 2 isolated from blood of patient by vitek-2 method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Carbapenem-resistant KPC-2-producing Escherichia coli in a Tel Aviv Medical Center, 2005 to 2008. |
| AID678868 | TP_TRANSPORTER: inhibition of Gly-Sar uptake (Gly-Sar: 25 uM, Cefepime: 2500uM) in PEPT2-expressing HeLa cells | 2000 | The Journal of biological chemistry, Jan-21, Volume: 275, Issue:3 | beta-lactam antibiotics as substrates for OCTN2, an organic cation/carnitine transporter. |
| AID574429 | Antimicrobial activity against Escherichia coli isolate 386 expressing beta-lactamase KPC2, CTX-M-15, OXA-9, TEM and PFGE cluster 1 isolated from wound of patient by vitek-2 method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Carbapenem-resistant KPC-2-producing Escherichia coli in a Tel Aviv Medical Center, 2005 to 2008. |
| AID555213 | Antibacterial activity against Acinetobacter genomosp. 3 isolate 195 by Etest method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Genetic variability among ampC genes from acinetobacter genomic species 3. |
| AID285580 | Antimicrobial activity against Pseudomonas aeruginosa IC7 tracheal isolates from mechanically ventilated tuberculosis patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID368535 | Activity of Providencia stuartii AmpC assessed as drug hydrolysis by spectrophotometry | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID540213 | Half life in human after iv administration | 2008 | Drug metabolism and disposition: the biological fate of chemicals, Jul, Volume: 36, Issue:7 | Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. |
| AID535367 | Antimicrobial activity against Pseudomonas aeruginosa isolated from non-ICU patient by broth microdilution method in presence of Tazobactam | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activity of doripenem, a carbapenem for the treatment of challenging infections caused by gram-negative bacteria, against recent clinical isolates from the United States. |
| AID535727 | Antibacterial activity against Klebsiella pneumoniae urine isolate A28011 PFGE pattern A expressing KPC-2 CTX-M-2 beta-lactamase by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | First report of KPC-2-producing Klebsiella pneumoniae strains in Brazil. |
| AID285440 | Antimicrobial activity against Escherichia coli DH10B expressing GIL1 after 18 hrs by disk diffusion method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Chromosome-encoded narrow-spectrum Ambler class A beta-lactamase GIL-1 from Citrobacter gillenii. |
| AID546177 | Antimicrobial activity against AmpC overproducing Pseudomonas aeruginosa isolate Pae-beta-17 with PDC-3 variant by Etest | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Extended-spectrum cephalosporinases in Pseudomonas aeruginosa. |
| AID1592960 | Antibacterial activity against multi-drug resistant Klebsiella pneumoniae NMI 3081/09 assessed as reduction in microbial growth incubated for 20 hrs | 2019 | European journal of medicinal chemistry, Apr-15, Volume: 168 | Microwave-assisted solid-phase synthesis of antisense acpP peptide nucleic acid-peptide conjugates active against colistin- and tigecycline-resistant E. coli and K. pneumoniae. |
| AID368312 | Ratio of Kcat to Km of Staphylococcus aureus betalactamase PC1 assessed as drug hydrolysis by spectrophotometry | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID540210 | Clearance in human after iv administration | 2008 | Drug metabolism and disposition: the biological fate of chemicals, Jul, Volume: 36, Issue:7 | Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. |
| AID565282 | Antibacterial activity against mexB and mexY expressing Pseudomonas aeruginosa PA-A3 harboring GyrA T83I, ParC S87L and IS1001 insertion at position 629 in OprD gene by Etest method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Nosocomial spread of colistin-only-sensitive sequence type 235 Pseudomonas aeruginosa isolates producing the extended-spectrum beta-lactamases GES-1 and GES-5 in Spain. |
| AID565768 | Antimicrobial activity against Pseudomonas aeruginosa OC 12070 expressing 10 fold elevated mexX expression and 23 fold elevated mexY expression by broth macrodilution method | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | Differential selection of single-step AmpC or efflux mutants of Pseudomonas aeruginosa by using cefepime, ceftazidime, or ceftobiprole. |
| AID560128 | Antimicrobial activity against Acinetobacter baumannii CIP70.10 by disk diffusion method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Genetic and biochemical characterization of the first extended-spectrum CARB-type beta-lactamase, RTG-4, from Acinetobacter baumannii. |
| AID625288 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for jaundice | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID373030 | Antimicrobial activity against imipenem and meropenem-resistant Acinetobacter baumannii isolate PU78 by CLSI agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Molecular epidemiology of clinical isolates of carbapenem-resistant Acinetobacter spp. from Chinese hospitals. |
| AID498817 | Antimicrobial activity against Klebsiella pneumoniae FZ49T expressing IMP-8, TEM-1, CTX-M-14, qnrB2, aac(6')-Ib by CLSI method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Phenotypic and genotypic characterization of Enterobacteriaceae with decreased susceptibility to carbapenems: results from large hospital-based surveillance studies in China. |
| AID283218 | Antimicrobial susceptibility of Burkholderia cepacia complex isolated from cystic fibrosis patient assessed as percent susceptible isolates | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3 | Antimicrobial susceptibility and synergy studies of Burkholderia cepacia complex isolated from patients with cystic fibrosis. |
| AID529659 | Activity of Pseudomonas aeruginosa COL-1 beta-lactamase VIM-2 | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | VIM-15 and VIM-16, two new VIM-2-like metallo-beta-lactamases in Pseudomonas aeruginosa isolates from Bulgaria and Germany. |
| AID285257 | Antimicrobial activity against recombinant Escherichia coli DH5-alpha CL1295 isolate expressing pBK-TEM-151 and CMT by disk diffusion assay | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Evolution of TEM-type enzymes: biochemical and genetic characterization of two new complex mutant TEM enzymes, TEM-151 and TEM-152, from a single patient. |
| AID522581 | Antimicrobial activity against AmpC producing Escherichia coli Top10 isolate 25922 | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Occurrence of ST23 complex phylogroup A Escherichia coli isolates producing extended-spectrum AmpC beta-lactamase in a French hospital. |
| AID560489 | Antibacterial activity against 5 x 10'5 CFU/ml CMY-2 producing Escherichia coli MC4100 harboring plasmid AC-cmy2 by microdilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Extended-spectrum properties of CMY-30, a Val211Gly mutant of CMY-2 cephalosporinase. |
| AID534085 | Antibacterial activity against erythromycin-resistant Streptococcus pneumoniae assessed as percent susceptible isolates by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | In vitro activity of ceftaroline against Streptococcus pneumoniae isolates exhibiting resistance to penicillin, amoxicillin, and cefotaxime. |
| AID322314 | Antibacterial activity against CTX-M group 1 enzyme producing Escherichia coli isolates assessed as percent resistant isolates by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Spread of extended-spectrum beta-lactamase CTX-M-producing escherichia coli clinical isolates in community and nosocomial environments in Portugal. |
| AID524572 | Antimicrobial activity against Shigella flexneri isolate AM26336 by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Identification and characterization of CTX-M-producing Shigella isolates in the United States. |
| AID573356 | Antibacterial activity against ceftazidime-nonsusceptible Escherichia coli assessed as susceptible isolates by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID532202 | Antimicrobial activity against aac(6')-Ib-cr-positive Klebsiella pneumoniae WH99 harboring wild-type GyrA, ParC, GyrB and qnrB genes by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | High prevalence of plasmid-mediated quinolone resistance genes qnr and aac(6')-Ib-cr in clinical isolates of Enterobacteriaceae from nine teaching hospitals in China. |
| AID576299 | Antimicrobial activity against ESBL-positive Klebsiella pneumoniae 25008 by Etest | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | An ertapenem-resistant extended-spectrum-beta-lactamase-producing Klebsiella pneumoniae clone carries a novel OmpK36 porin variant. |
| AID498814 | Antimicrobial activity against carbapenem-resistant Klebsiella pneumoniae FZ47 deficient in IMP-8, TEM-1, SHV-11, CTX-M-14, qnrB2, aac(6')-Ib, ompK35/36 by CLSI method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Phenotypic and genotypic characterization of Enterobacteriaceae with decreased susceptibility to carbapenems: results from large hospital-based surveillance studies in China. |
| AID535666 | Antimicrobial activity against aac(6')-Ib-cr-negative Enterobacter cloacae FJ67 harboring wild-type GyrA S83I and qnrS genes by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | High prevalence of plasmid-mediated quinolone resistance genes qnr and aac(6')-Ib-cr in clinical isolates of Enterobacteriaceae from nine teaching hospitals in China. |
| AID567319 | Antimicrobial activity against Escherichia coli TUM4672 by broth dilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Chromosomally encoded blaCMY-2 located on a novel SXT/R391-related integrating conjugative element in a Proteus mirabilis clinical isolate. |
| AID324360 | Antibacterial activity against Acinetobacter johnsonii 7037 expressing SCO1 by agar dilution technique | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Identification of the novel narrow-spectrum beta-lactamase SCO-1 in Acinetobacter spp. from Argentina. |
| AID498816 | Antimicrobial activity against carbapenem-resistant Klebsiella pneumoniae FZ49 deficient in IMP-8, TEM-1, SHV-11, CTX-M-14, qnrB2, aac(6')-Ib, ompK35/36 by CLSI method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Phenotypic and genotypic characterization of Enterobacteriaceae with decreased susceptibility to carbapenems: results from large hospital-based surveillance studies in China. |
| AID520972 | Antibacterial activity against Escherichia coli harboring pBC633 plasmid expressing blaKPC gene by Etest method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Genetic structures at the origin of acquisition of the beta-lactamase bla KPC gene. |
| AID373763 | Antibacterial activity against imipenem-resistant Acinetobacter baumannii abh9 by broth dilution method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | An OXA-66/OXA-51-like carbapenemase and possibly an efflux pump are associated with resistance to imipenem in Acinetobacter baumannii. |
| AID583087 | Ratio of Kcat to Km for Escherichia coli XL1-Blue VIM-2 A64W mutant beta-lactamase by spectrophotometer | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | Mutational analysis of VIM-2 reveals an essential determinant for metallo-beta-lactamase stability and folding. |
| AID559277 | Antimicrobial activity against rifampin-resistant Escherichia coli J53 transconjugated with Proteus vulgaris Pv9 expressing beta-lactamase PER-1 by Etest | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Emergence of extended-spectrum beta-lactamase PER-1 in Proteus vulgaris and Providencia stuartii isolates from Algiers, Algeria. |
| AID565529 | Antibacterial activity against mexB, mexY and mexD expressing Pseudomonas aeruginosa isolate Paebeta-06 harboring A residue at 105 position in PDC- 2 and insertion of ISPa27 sequence in OprD gene by Etest method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Molecular epidemiology and mechanisms of carbapenem resistance in Pseudomonas aeruginosa. |
| AID285656 | Antimicrobial activity against Pseudomonas aeruginosa 19E1 tracheal isolates from mechanically ventilated chronic respiratory insufficiency patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID499049 | Antimicrobial activity against carbapenem-resistant Klebsiella pneumoniae PU104 deficient in TEM-1, SHV-11, CTX-M-15, qnrS1, ompK35/36 by CLSI method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Phenotypic and genotypic characterization of Enterobacteriaceae with decreased susceptibility to carbapenems: results from large hospital-based surveillance studies in China. |
| AID561668 | Antimicrobial activity against Pseudomonas aeruginosa isolate OC16827 harboring plasmid JAK16 expressing mexXY gene by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Effect of MexXY overexpression on ceftobiprole susceptibility in Pseudomonas aeruginosa. |
| AID530342 | Ratio of Kcat to Km for Pseudomonas aeruginosa VIM-13 beta-lactamase | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Characterization of the new metallo-beta-lactamase VIM-13 and its integron-borne gene from a Pseudomonas aeruginosa clinical isolate in Spain. |
| AID583014 | Antimicrobial activity against Escherichia coli TOP10 transformed with Escherichia coli ECB2 plasmid carrying CMY-2 by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Phenotypic and biochemical comparison of the carbapenem-hydrolyzing activities of five plasmid-borne AmpC β-lactamases. |
| AID1139538 | Antibacterial activity against Escherichia coli DH5alpha expressing beta-lactamase SHV-5 by CLSI broth microdilution method | 2014 | Journal of medicinal chemistry, May-08, Volume: 57, Issue:9 | Siderophore receptor-mediated uptake of lactivicin analogues in gram-negative bacteria. |
| AID679481 | TP_TRANSPORTER: inhibition of Carnitine uptake (Carnitine: 0.02 uM) in OCTN2-expressing HeLa cells | 2000 | The Journal of biological chemistry, Jan-21, Volume: 275, Issue:3 | beta-lactam antibiotics as substrates for OCTN2, an organic cation/carnitine transporter. |
| AID544821 | Antimicrobial activity against Pseudomonas aeruginosa Xen 5 biofilm assessed as log10 CFU/cm'2 in bacterial count | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Effect of electrical current on the activities of antimicrobial agents against Pseudomonas aeruginosa, Staphylococcus aureus, and Staphylococcus epidermidis biofilms. |
| AID510504 | Antibacterial activity against Acinetobacter calcoaceticus/baumannii complex isolate M3AC9-2 expressing KPC beta lactamase | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Detection of KPC in Acinetobacter spp. in Puerto Rico. |
| AID532181 | Antimicrobial activity against aac(6')-Ib-cr-negative Klebsiella pneumoniae SY22T harboring qnrS gene by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | High prevalence of plasmid-mediated quinolone resistance genes qnr and aac(6')-Ib-cr in clinical isolates of Enterobacteriaceae from nine teaching hospitals in China. |
| AID520880 | Antibacterial activity against Achromobacter xylosoxidans TB1 by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Characterization of a naturally occurring class D beta-lactamase from Achromobacter xylosoxidans. |
| AID559904 | Antimicrobial activity against Escherichia coli TF-KP278 harboring beta-lactamase OXY-1 by Etest method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | First detection of plasmid-encoded blaOXY beta-lactamase. |
| AID576262 | Antimicrobial activity against ESBL-positive Klebsiella pneumoniae 17829 harboring pSHA2-encoded porin OmpK36 gene by Etest | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | An ertapenem-resistant extended-spectrum-beta-lactamase-producing Klebsiella pneumoniae clone carries a novel OmpK36 porin variant. |
| AID532187 | Antimicrobial activity against aac(6')-Ib-cr-positive Klebsiella pneumoniae SY26T harboring wild-type GyrA, ParC, GyrB and qnrB genes by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | High prevalence of plasmid-mediated quinolone resistance genes qnr and aac(6')-Ib-cr in clinical isolates of Enterobacteriaceae from nine teaching hospitals in China. |
| AID557199 | Serum creatinine level in critically ill patient with ventilator-associated pneumoniae at 2 g/kg administered as 3 hr infusion every 8 hrs by HPLC | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Population pharmacokinetics of high-dose, prolonged-infusion cefepime in adult critically ill patients with ventilator-associated pneumonia. |
| AID522565 | Antimicrobial activity against Escherichia coli isolate 7008211 with AmpC beta-lactamase H296P mutation | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Occurrence of ST23 complex phylogroup A Escherichia coli isolates producing extended-spectrum AmpC beta-lactamase in a French hospital. |
| AID565720 | Antibacterial activity against oprD, mexB, mexY and mexD expressing Pseudomonas aeruginosa isolate Paebeta-25 harboring T residue at 105 position in PDC- 6 by Etest method in presence of cloxacillin | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Molecular epidemiology and mechanisms of carbapenem resistance in Pseudomonas aeruginosa. |
| AID571032 | Antimicrobial activity against Pseudomonas aeruginosa PAO1 by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Role of ampD homologs in overproduction of AmpC in clinical isolates of Pseudomonas aeruginosa. |
| AID535713 | Antibacterial activity against Escherichia coli TOP10 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Role of the Ser-287-Asn replacement in the hydrolysis spectrum extension of AmpC beta-lactamases in Escherichia coli. |
| AID283322 | Antimicrobial activity against Escherichia coli XL10/pSHV-31 | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3 | Detection of a new SHV-type extended-spectrum beta-lactamase, SHV-31, in a Klebsiella pneumoniae strain causing a large nosocomial outbreak in The Netherlands. |
| AID564524 | Antimicrobial activity against Acinetobacter baumannii KI by Etest method | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | Extended-spectrum cephalosporinase in Acinetobacter baumannii. |
| AID571939 | Antimicrobial activity against Escherichia coli MC4100 expressing promoterless beta-lactamase GES-1 by Etest | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Relative strengths of the class 1 integron promoter hybrid 2 and the combinations of strong and hybrid 1 with an active p2 promoter. |
| AID525504 | fT>MIC in Pseudomonas aeruginosa infected patient at 2 g,iv administered as 3 hrs infusion every 8 hrs | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Clinical pharmacodynamics of cefepime in patients infected with Pseudomonas aeruginosa. |
| AID567753 | Antimicrobial activity against Pseudomonas aeruginosa OC 12070 expressing 8 fold elevated AmpC expression by broth macrodilution method | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | Differential selection of single-step AmpC or efflux mutants of Pseudomonas aeruginosa by using cefepime, ceftazidime, or ceftobiprole. |
| AID546409 | Antimicrobial activity against AmpC overproducing Pseudomonas aeruginosa isolate Pae-beta-26 with PDC-6 variant by Etest | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Extended-spectrum cephalosporinases in Pseudomonas aeruginosa. |
| AID1373286 | Antimicrobial activity against Escherichia coli expressing beta-lactamase KPC-3 by CLSI broth microdilution method | 2018 | Bioorganic & medicinal chemistry letters, 02-15, Volume: 28, Issue:4 | Optimization of novel monobactams with activity against carbapenem-resistant Enterobacteriaceae - Identification of LYS228. |
| AID520966 | Antibacterial activity against Klebsiella pneumoniae YC by Etest method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Genetic structures at the origin of acquisition of the beta-lactamase bla KPC gene. |
| AID556668 | Antimicrobial activity against multidrug resistant Enterobacter aerogenes isolate 23 by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Occurrence of efflux mechanism and cephalosporinase variant in a population of Enterobacter aerogenes and Klebsiella pneumoniae isolates producing extended-spectrum beta-lactamases. |
| AID528842 | Antimicrobial activity against penicillin-resistant Streptococcus pneumoniae isolated from ICU patient blood assessed as resistant isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Antimicrobial-resistant pathogens in intensive care units in Canada: results of the Canadian National Intensive Care Unit (CAN-ICU) study, 2005-2006. |
| AID545461 | Antimicrobial activity against Pasteurella sp. assessed as percent susceptible isolates by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Susceptibility of gram-negative pathogens isolated from patients with complicated intra-abdominal infections in the United States, 2007-2008: results of the Study for Monitoring Antimicrobial Resistance Trends (SMART). |
| AID567732 | Antimicrobial activity against Pseudomonas aeruginosa OC 11053 by broth macrodilution method | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | Differential selection of single-step AmpC or efflux mutants of Pseudomonas aeruginosa by using cefepime, ceftazidime, or ceftobiprole. |
| AID567752 | Antimicrobial activity against Pseudomonas aeruginosa OC 12070 expressing 11 fold elevated AmpC expression by broth macrodilution method | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | Differential selection of single-step AmpC or efflux mutants of Pseudomonas aeruginosa by using cefepime, ceftazidime, or ceftobiprole. |
| AID522380 | Antimicrobial activity against blaKPC-possessing Klebsiella pneumoniae isolates in presence of 4 ug/ml by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | In vitro activity of penem-1 in combination with beta-lactams against blaKPC-possessing Klebsiella pneumoniae isolates. |
| AID524934 | Antimicrobial activity against Escherichia coli MI1443 harboring V27A, Q38R, A77V and D240G mutations in beta lactamase CTX-M-3 by E-test | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Mutational events in cefotaximase extended-spectrum beta-lactamases of the CTX-M-1 cluster involved in ceftazidime resistance. |
| AID533881 | Antibacterial activity against cefotaxime-intermediate Streptococcus pneumoniae assessed as percent susceptible isolates by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | In vitro activity of ceftaroline against Streptococcus pneumoniae isolates exhibiting resistance to penicillin, amoxicillin, and cefotaxime. |
| AID252619 | Mean lysis diameter was measured against Enterobacter aerogenes EA289 with D121A mutation by standard disk diffusion method on MH agar | 2005 | Journal of medicinal chemistry, Mar-10, Volume: 48, Issue:5 | Beta-lactam screening by specific residues of the OmpF eyelet. |
| AID535864 | Antimicrobial activity against aac(6')-Ib-cr-negative Enterobacter cloacae GZ47T harboring qnrB gene by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | High prevalence of plasmid-mediated quinolone resistance genes qnr and aac(6')-Ib-cr in clinical isolates of Enterobacteriaceae from nine teaching hospitals in China. |
| AID565536 | Antibacterial activity against oprD, mexB, mexY and mexD expressing Pseudomonas aeruginosa isolate Paebeta-32 harboring A residue at 105 position in PDC- 10 by Etest method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Molecular epidemiology and mechanisms of carbapenem resistance in Pseudomonas aeruginosa. |
| AID520796 | Antimicrobial activity against SHV-5 producing Klebsiella pneumoniae with PFGE pulsotype D by Etest | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Multiclonal outbreak of Klebsiella pneumoniae producing extended-spectrum beta-lactamase CTX-M-2 and novel variant CTX-M-59 in a neonatal intensive care unit in Brazil. |
| AID373760 | Antibacterial activity against imipenem-intermediate Acinetobacter baumannii ab1297 by broth dilution method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | An OXA-66/OXA-51-like carbapenemase and possibly an efflux pump are associated with resistance to imipenem in Acinetobacter baumannii. |
| AID405086 | Ratio of Kcat to Km of Citrobacter freundii PER2 beta lactamase relative to cephalothin | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | Biochemical characterization of PER-2 and genetic environment of blaPER-2. |
| AID535643 | Antimicrobial activity against Group B streptococcus serotype III N3 by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | Genetic heterogeneity in pbp genes among clinically isolated group B Streptococci with reduced penicillin susceptibility. |
| AID529457 | Antimicrobial activity against Klebsiella pneumoniae containing PFGE clone B expressing beta-lactamase Oxa-48, TEM-1, CTX-M-15 and Oxa-1 by Etest | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Spread of OXA-48-positive carbapenem-resistant Klebsiella pneumoniae isolates in Istanbul, Turkey. |
| AID567321 | Antimicrobial activity against Escherichia coli ML4901 by broth dilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Chromosomally encoded blaCMY-2 located on a novel SXT/R391-related integrating conjugative element in a Proteus mirabilis clinical isolate. |
| AID583015 | Antimicrobial activity against OmpC/OmpF porin deficient Escherichia coli HB4 by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Phenotypic and biochemical comparison of the carbapenem-hydrolyzing activities of five plasmid-borne AmpC β-lactamases. |
| AID544635 | Antimicrobial activity against Pseudomonas aeruginosa Xen 5 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Effect of electrical current on the activities of antimicrobial agents against Pseudomonas aeruginosa, Staphylococcus aureus, and Staphylococcus epidermidis biofilms. |
| AID535060 | Antimicrobial activity against Acinetobacter genomic species 13TU ATCC 17903 by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | Contribution of a plasmid-borne blaOXA-58 gene with its hybrid promoter provided by IS1006 and an ISAba3-like element to beta-lactam resistance in acinetobacter genomic species 13TU. |
| AID531974 | Antibacterial activity against Escherichia coli DH10B by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | First report of KPC-2-producing Klebsiella pneumoniae strains in Brazil. |
| AID522011 | Antimicrobial activity against Klebsiella pneumoniae isolate KpE expressing beta-lactamase OXA-48 and CTX-M-15 by Etest method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Spread of OXA-48-encoding plasmid in Turkey and beyond. |
| AID554390 | Antimicrobial activity against Pseudomonas aeruginosa isolate 615S obtained from cystic fibrosis patient by disk diffusion method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Efflux unbalance in Pseudomonas aeruginosa isolates from cystic fibrosis patients. |
| AID368548 | Activity of Pseudomonas aeruginosa MK-1184 AmpC assessed as drug hydrolysis by spectrophotometry relative to cephaloridine | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID394714 | Antibacterial activity against Pseudomonas aeruginosa clinical isolates assessed as susceptible rate by macrodilution technique | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10 | Pseudomonas aeruginosa may accumulate drug resistance mechanisms without losing its ability to cause bloodstream infections. |
| AID532398 | Antibacterial activity against VIM-1 producing Pseudomonas aeruginosa clone D1 isolate VA-06X-63 by Etest method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | First countrywide survey of acquired metallo-beta-lactamases in gram-negative pathogens in Italy. |
| AID556685 | Antimicrobial activity against multidrug resistant Klebsiella pneumoniae isolate 12 by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Occurrence of efflux mechanism and cephalosporinase variant in a population of Enterobacter aerogenes and Klebsiella pneumoniae isolates producing extended-spectrum beta-lactamases. |
| AID518824 | Antibacterial activity against Pulsotype L Acinetobacter genomosp. 3 isolate 2 containing IMP-8, OXA-58, ADC-43, ISAba1, ISAba3, IS1008, intI1 genetic elements by broth micro dilution | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Molecular characterization of beta-lactamase genes and their genetic structures in Acinetobacter genospecies 3 isolates in Taiwan. |
| AID533568 | Antimicrobial activity against Pseudomonas aeruginosa isolate PA469 expressing VIM-2 beta-lactamase | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | First survey of metallo-beta-lactamases in clinical isolates of Pseudomonas aeruginosa in a German university hospital. |
| AID544490 | Antibacterial activity against Pseudomonas aeruginosa PR280 harboring beta-lactamase KPC-5 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Phenotypic and enzymatic comparative analysis of the novel KPC variant KPC-5 and its evolutionary variants, KPC-2 and KPC-4. |
| AID546417 | Antimicrobial activity against Pseudomonas aeruginosa KG2505a harboring recombinant pBB-PDC-2 by Etest | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Extended-spectrum cephalosporinases in Pseudomonas aeruginosa. |
| AID531749 | Antibacterial activity against Pseudomonas aeruginosa FK06 by twofold serial dilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Resistance and virulence of Pseudomonas aeruginosa clinical strains overproducing the MexCD-OprJ efflux pump. |
| AID405643 | Inhibition of bocillin FL binding to Pseudomonas aeruginosa PAO1 penicillin-binding protein 2 | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | Binding of ceftobiprole and comparators to the penicillin-binding proteins of Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Streptococcus pneumoniae. |
| AID567303 | Antimicrobial activity against SHV-12 ESBL producing Pseudomonas aeruginosa isolate 2201 isolated from burn patient by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Acquisition of a transposon encoding extended-spectrum beta-lactamase SHV-12 by Pseudomonas aeruginosa isolates during the clinical course of a burn patient. |
| AID499046 | Antimicrobial activity against Klebsiella pneumoniae ZJ68T expressing CTX-M-15 by CLSI method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Phenotypic and genotypic characterization of Enterobacteriaceae with decreased susceptibility to carbapenems: results from large hospital-based surveillance studies in China. |
| AID582973 | Antimicrobial activity against dacB::lox gene-deficient Pseudomonas aeruginosa PAO1 by Etest method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | NagZ inactivation prevents and reverts beta-lactam resistance, driven by AmpD and PBP 4 mutations, in Pseudomonas aeruginosa. |
| AID519983 | Activity of Klebsiella pneumoniae Beta-Lactamase SHV-1 | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Biochemical characterization of SHV-55, an extended-spectrum class A beta-lactamase from Klebsiella pneumoniae. |
| AID531316 | Ratio of Kcat to Km for Pseudomonas aeruginosa beta-lactamase VIM-2 by spectrophotometry | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Kinetic characterization of VIM-7, a divergent member of the VIM metallo-beta-lactamase family. |
| AID325194 | Antibacterial activity against Pseudomonas aeruginosa SR-5393 by standard serial agar dilution method | 2008 | Bioorganic & medicinal chemistry, Feb-15, Volume: 16, Issue:4 | A novel series of parenteral cephalosporins exhibiting potent activities against both Pseudomonas aeruginosa and other gram-negative pathogens. Part 2: Synthesis and structure-activity relationships. |
| AID562766 | Antimicrobial activity against Escherichia coli DH10B transformant harboring blaTEM-168 gene by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | TEM-168, a heretofore laboratory-derived TEM beta-lactamase variant found in an Escherichia coli clinical isolate. |
| AID519740 | Antibacterial activity against Escherichia coli DH5alpha expressing Klebsiella pneumoniae beta-lactamase SHV-72 by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | The Lys234Arg substitution in the enzyme SHV-72 is a determinant for resistance to clavulanic acid inhibition. |
| AID524936 | Antimicrobial activity against Escherichia coli MI1443 harboring V27A, Q38R, N106S and P167S mutations in beta lactamase CTX-M-3 by E-test | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Mutational events in cefotaximase extended-spectrum beta-lactamases of the CTX-M-1 cluster involved in ceftazidime resistance. |
| AID560060 | Antimicrobial activity against Pseudomonas aeruginosa by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | In vitro activity of ceftaroline alone and in combination against clinical isolates of resistant gram-negative pathogens, including beta-lactamase-producing Enterobacteriaceae and Pseudomonas aeruginosa. |
| AID535756 | Antimicrobial activity against hospital-acquired Escherichia coli obtained from patient with intra-abdominal infection assessed as susceptible isolates by EUCAST method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Incidence and antimicrobial susceptibility of Escherichia coli and Klebsiella pneumoniae with extended-spectrum beta-lactamases in community- and hospital-associated intra-abdominal infections in Europe: results of the 2008 Study for Monitoring Antimicrob |
| AID571924 | Antimicrobial activity against ISAba1 linked with the blaOXA-51-type beta-lactamase harboring Acinetobacter baumannii zeta clonal group isolate 26 expressing ampC, ompA, adeB, adeM, aadA1, aacA4, aacC2, blaSHV-5 by Etest method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Correlation of antimicrobial resistance with beta-lactamases, the OmpA-like porin, and efflux pumps in clinical isolates of Acinetobacter baumannii endemic to New York City. |
| AID560488 | Antibacterial activity against 5 x 10'5 CFU/ml CMY-30 producing Escherichia coli MC4100 harboring plasmid AC-cmy30 by microdilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Extended-spectrum properties of CMY-30, a Val211Gly mutant of CMY-2 cephalosporinase. |
| AID546424 | Antimicrobial activity against Pseudomonas aeruginosa 12B harboring recombinant pBB-PDC-4 by Etest | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Extended-spectrum cephalosporinases in Pseudomonas aeruginosa. |
| AID1079945 | Animal toxicity known. [column 'TOXIC' in source] | |||
| AID522385 | Antimicrobial activity against Aeromonas enteropelogenes M1 hyperproducing beta-lactamase AmpC | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Genetic and biochemical characterization of TRU-1, the endogenous class C beta-lactamase from Aeromonas enteropelogenes. |
| AID567281 | Ratio of Kcat to Km for Acinetobacter baumannii ADC-33 beta-lactamase | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | Extended-spectrum cephalosporinase in Acinetobacter baumannii. |
| AID521996 | Antimicrobial activity against Escherichia coli isolate J53 harboring p3A containing beta-lactamase OXA-48 located within transposon Tn1999 by Etest method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Spread of OXA-48-encoding plasmid in Turkey and beyond. |
| AID524571 | Antimicrobial activity against Shigella isolate DH-22855 by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Identification and characterization of CTX-M-producing Shigella isolates in the United States. |
| AID531747 | Antibacterial activity against Pseudomonas aeruginosa EryR by twofold serial dilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Resistance and virulence of Pseudomonas aeruginosa clinical strains overproducing the MexCD-OprJ efflux pump. |
| AID573380 | Antibacterial activity against beta lactamase-negative Haemophilus influenzae assessed as susceptible isolates by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID576290 | Antimicrobial activity against ESBL-positive Klebsiella pneumoniae 6267 harboring porin OmpK36V mutant gene by Etest | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | An ertapenem-resistant extended-spectrum-beta-lactamase-producing Klebsiella pneumoniae clone carries a novel OmpK36 porin variant. |
| AID534305 | Antimicrobial activity against metallo-beta-lactamase-negative Pseudomonas aeruginosa isolate PA507 | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | First survey of metallo-beta-lactamases in clinical isolates of Pseudomonas aeruginosa in a German university hospital. |
| AID521840 | Antibacterial activity against Escherichia coli J53 transconjugated with Klebsiella pneumoniae isolate VA375 containing qnrA1, blaTEM-1, blaSHV-11genes by CLSI method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Presence of plasmid-mediated quinolone resistance in Klebsiella pneumoniae isolates possessing blaKPC in the United States. |
| AID583097 | Antimicrobial activity against Escherichia coli XL1-Blue harboring pLBII-VIM-2 plasmid expressing VIM-2 A64W mutant beta-lactamase by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | Mutational analysis of VIM-2 reveals an essential determinant for metallo-beta-lactamase stability and folding. |
| AID532392 | Antibacterial activity against VIM-1 producing Pseudomonas aeruginosa clone A2 isolate NA-14X-21 by Etest method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | First countrywide survey of acquired metallo-beta-lactamases in gram-negative pathogens in Italy. |
| AID565513 | Antibacterial activity against oprD, mexB, mexY and mexD expressing Pseudomonas aeruginosa isolate Paebeta-22 harboring A residue at 105 position in PDC- 4 by Etest method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Molecular epidemiology and mechanisms of carbapenem resistance in Pseudomonas aeruginosa. |
| AID567744 | Antimicrobial activity against Pseudomonas aeruginosa OC 11678 expressing 32 fold elevated AmpC expression by broth macrodilution method | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | Differential selection of single-step AmpC or efflux mutants of Pseudomonas aeruginosa by using cefepime, ceftazidime, or ceftobiprole. |
| AID368311 | Ratio of Kcat to Km of Staphylococcus aureus betalactamase PC1 assessed as drug hydrolysis by spectrophotometry relative to cephaloridine | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID525505 | Ratio of fCmax in Pseudomonas aeruginosa infected patient to MIC against Pseudomonas aeruginosa | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Clinical pharmacodynamics of cefepime in patients infected with Pseudomonas aeruginosa. |
| AID520387 | Ratio of Kcat to Km for Pseudomonas aeruginosa M5109 metallo-beta-lactamase VIM-11 | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Biochemical characterization of metallo-beta-lactamase VIM-11 from a Pseudomonas aeruginosa clinical strain. |
| AID495633 | Antimicrobial activity against Escherichia coli DH10B transfected with pBK-L3 expressing blaLUT-1 by Etest method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Molecular and biochemical characterization of the natural chromosome-encoded class A beta-lactamase from Pseudomonas luteola. |
| AID405636 | Inhibition of bocillin FL binding to Escherichia coli MC4100 penicillin-binding protein 6 | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | Binding of ceftobiprole and comparators to the penicillin-binding proteins of Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Streptococcus pneumoniae. |
| AID252635 | Bacterial susceptibility induced by D121 mutation in Escherichia coli OmpF | 2005 | Journal of medicinal chemistry, Mar-10, Volume: 48, Issue:5 | Beta-lactam screening by specific residues of the OmpF eyelet. |
| AID285614 | Antimicrobial activity against Pseudomonas aeruginosa 3D1 tracheal isolates from mechanically ventilated chronic respiratory insufficiency patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID529896 | Antimicrobial activity against Leptospira interrogans serovar Pomona isolate 4 by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Antimicrobial susceptibilities of geographically diverse clinical human isolates of Leptospira. |
| AID528968 | Antimicrobial activity against methicillin-susceptible Staphylococcus epidermidis assessed as resistant isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Antimicrobial-resistant pathogens in intensive care units in Canada: results of the Canadian National Intensive Care Unit (CAN-ICU) study, 2005-2006. |
| AID573353 | Antibacterial activity against ceftazidime-susceptible Escherichia coli assessed as susceptible isolates by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID498808 | Antimicrobial activity against Klebsiella pneumoniae ZJ99 expressing KPC-2, CTX-M-3, qnrS1, ompK35 DE by CLSI method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Phenotypic and genotypic characterization of Enterobacteriaceae with decreased susceptibility to carbapenems: results from large hospital-based surveillance studies in China. |
| AID405637 | Inhibition of bocillin FL binding to Escherichia coli MC4100 penicillin-binding protein 5 | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | Binding of ceftobiprole and comparators to the penicillin-binding proteins of Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Streptococcus pneumoniae. |
| AID583643 | Cmin in febrile neutropenic patient without neurological disorder at 2 g administered as 30 mins infusion every 8 hrs measured after 4 days by HPLC analysis | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | High cefepime plasma concentrations and neurological toxicity in febrile neutropenic patients with mild impairment of renal function. |
| AID285627 | Antimicrobial activity against Pseudomonas aeruginosa 9A7 tracheal isolates from mechanically ventilated chronic respiratory insufficiency patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID520386 | Activity at Pseudomonas aeruginosa COL-1 metallo-beta lactamase VIM-2 by spectrometry | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Biochemical characterization of metallo-beta-lactamase VIM-11 from a Pseudomonas aeruginosa clinical strain. |
| AID535634 | Antimicrobial activity against Group B streptococcus serotype VI R6 harboring F395L, V405A, R433H, H438Y, A374V and G648A mutations in PBP 2X and T567I mutation in PBP 2B by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | Genetic heterogeneity in pbp genes among clinically isolated group B Streptococci with reduced penicillin susceptibility. |
| AID540942 | Antimicrobial activity against Salmonella enterica serotype Newport AM17274 expressing CMY-31 cephalosporinase by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | CMY-31 and CMY-36 cephalosporinases encoded by ColE1-like plasmids. |
| AID556679 | Antimicrobial activity against multidrug resistant Klebsiella pneumoniae isolate 6 by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Occurrence of efflux mechanism and cephalosporinase variant in a population of Enterobacter aerogenes and Klebsiella pneumoniae isolates producing extended-spectrum beta-lactamases. |
| AID295847 | Antimicrobial activity against Streptococcus pyogenes ATCC 176 by disk diffusion method at 300 ug/disc | 2007 | European journal of medicinal chemistry, Jul, Volume: 42, Issue:7 | Synthesis of some novel heterocyclic compounds derived from diflunisal hydrazide as potential anti-infective and anti-inflammatory agents. |
| AID521348 | Antimicrobial activity against Streptococcus pneumoniae isolate 187 obtained from bronchoalveolar lavage fluid of patient | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Highly variable penicillin resistance determinants PBP 2x, PBP 2b, and PBP 1a in isolates of two Streptococcus pneumoniae clonal groups, Poland 23F-16 and Poland 6B-20. |
| AID522580 | Antimicrobial activity against wild-type AmpC producing Escherichia coli ATCC 25922 | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Occurrence of ST23 complex phylogroup A Escherichia coli isolates producing extended-spectrum AmpC beta-lactamase in a French hospital. |
| AID573357 | Antibacterial activity against ceftazidime-nonsusceptible Escherichia coli assessed as resistant isolates by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID285681 | Antimicrobial activity against Pseudomonas aeruginosa 29H1 tracheal isolates from mechanically ventilated chronic respiratory insufficiency patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID285657 | Antimicrobial activity against Pseudomonas aeruginosa 19E2 tracheal isolates from mechanically ventilated chronic respiratory insufficiency patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID565515 | Antibacterial activity against oprD, mexB, mexY and mexD expressing Pseudomonas aeruginosa isolate Paebeta-20 harboring A residue at 105 position in PDC- 4 by Etest method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Molecular epidemiology and mechanisms of carbapenem resistance in Pseudomonas aeruginosa. |
| AID561387 | Antibacterial activity against Escherichia coli isolate ARL05-705 harboring beta-lactamase CMY 7 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | CMY-29 and CMY-30, two novel plasmid-mediated AmpC beta-lactamases. |
| AID559902 | Antimicrobial activity against Escherichia coli TF-KO279 harboring beta-lactamase OXY-1 by Etest method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | First detection of plasmid-encoded blaOXY beta-lactamase. |
| AID532031 | Antimicrobial activity against Escherichia coli TOP10F' by disk diffusion method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Novel chromosome-encoded CTX-M-78 beta-lactamase from a Kluyvera georgiana clinical isolate as a putative origin of CTX-M-25 subgroup. |
| AID508729 | Antibacterial activity against carbapenem-resistant Pseudomonas aeruginosa isolate 3C8 GM1 harboring acquired beta-lactamase OXA-144 by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2 | Activity of a new antipseudomonal cephalosporin, CXA-101 (FR264205), against carbapenem-resistant and multidrug-resistant Pseudomonas aeruginosa clinical strains. |
| AID508484 | Antimicrobial activity against Pseudomonas aeruginosa isolate BU-20287 producing metallo-beta-lactamase VIM2 by Etest | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Molecular epidemiology of metallo-beta-lactamase-producing Pseudomonas aeruginosa isolates from Norway and Sweden shows import of international clones and local clonal expansion. |
| AID530287 | Antimicrobial activity against PR-39-resistant sbmA-deficient Salmonella enterica serovar Typhimurium LT2 DA12088 by Etest | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Mechanism and fitness costs of PR-39 resistance in Salmonella enterica serovar Typhimurium LT2. |
| AID324860 | Antimicrobial activity against Acinetobacter baumannii A24B after 4 days by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Tigecycline Efflux as a Mechanism for Nonsusceptibility in Acinetobacter baumannii. |
| AID285603 | Antimicrobial activity against Pseudomonas aeruginosa 2B5 tracheal isolates from mechanically ventilated tuberculosis patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID522578 | Antimicrobial activity against Escherichia coli isolate 8009162 AmpC with A292V mutation | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Occurrence of ST23 complex phylogroup A Escherichia coli isolates producing extended-spectrum AmpC beta-lactamase in a French hospital. |
| AID547756 | Antimicrobial activity against invasive Streptococcus intermedius obtained from non-cystic fibrosis patient assessed as non-susceptible isolates grown on brain heart infusion agar at 30 ug/ml after 24 hrs at 37 degC by disk diffusion method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Macrolide and clindamycin resistance in Streptococcus milleri group isolates from the airways of cystic fibrosis patients. |
| AID565549 | Antibacterial activity against mexB, mexY and mexD expressing Pseudomonas aeruginosa isolate Paebeta-13 harboring A residue at 105 position in PDC- 2 and polymorphic OprD gene by Etest method in presence of cloxacillin | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Molecular epidemiology and mechanisms of carbapenem resistance in Pseudomonas aeruginosa. |
| AID528981 | Antimicrobial activity against Haemophilus influenzae isolated from ICU patient blood assessed as resistant isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Antimicrobial-resistant pathogens in intensive care units in Canada: results of the Canadian National Intensive Care Unit (CAN-ICU) study, 2005-2006. |
| AID524437 | Antimicrobial activity against Shigella isolate DH-19035 by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Identification and characterization of CTX-M-producing Shigella isolates in the United States. |
| AID495905 | Antimicrobial activity in Escherichia coli TOP10 hourbouring recombinant plasmid VIM-19 by Etest | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | VIM-19, a metallo-beta-lactamase with increased carbapenemase activity from Escherichia coli and Klebsiella pneumoniae. |
| AID508721 | Antibacterial activity against carbapenem-resistant Pseudomonas aeruginosa isolate 1C2 PTOL1 harboring beta-lactamase OXA-17 by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2 | Activity of a new antipseudomonal cephalosporin, CXA-101 (FR264205), against carbapenem-resistant and multidrug-resistant Pseudomonas aeruginosa clinical strains. |
| AID498829 | Antimicrobial activity against carbapenem-resistant Enterobacter cloacae RJ94 deficient in IMP-4, TEM-1, CTX-M-3, ompC by CLSI method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Phenotypic and genotypic characterization of Enterobacteriaceae with decreased susceptibility to carbapenems: results from large hospital-based surveillance studies in China. |
| AID528532 | Antimicrobial activity against penicillin-resistant Streptococcus agalactiae B68 by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | First molecular characterization of group B streptococci with reduced penicillin susceptibility. |
| AID681115 | TP_TRANSPORTER: inhibition of Gly-Sar uptake (pH6.0) in Caco-2 cells | 2005 | European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, Jan, Volume: 59, Issue:1 | Interaction of 31 beta-lactam antibiotics with the H+/peptide symporter PEPT2: analysis of affinity constants and comparison with PEPT1. |
| AID533756 | Antibacterial activity against SHV-2a producing Pseudomonas aeruginosa isolate P102 exhibiting PFGE H pattern by 2-fold agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | Nationwide investigation of extended-spectrum beta-lactamases, metallo-beta-lactamases, and extended-spectrum oxacillinases produced by ceftazidime-resistant Pseudomonas aeruginosa strains in France. |
| AID322325 | Antibacterial activity against Escherichia coli DH5 alpha-URA5924 isolates expressing CTX-M-32 by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Spread of extended-spectrum beta-lactamase CTX-M-producing escherichia coli clinical isolates in community and nosocomial environments in Portugal. |
| AID560091 | Bactericidal activity against Klebsiella pneumoniae isolate 5427 at 1/4 times MIC after 24 hrs by time kill analysis | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | In vitro activity of ceftaroline alone and in combination against clinical isolates of resistant gram-negative pathogens, including beta-lactamase-producing Enterobacteriaceae and Pseudomonas aeruginosa. |
| AID564019 | Antibacterial activity against Pseudomonas aeruginosa isolated from lung biopsy specimen of patient by Etest | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Detection of the novel extended-spectrum beta-lactamase OXA-161 from a plasmid-located integron in Pseudomonas aeruginosa clinical isolates from Spain. |
| AID285645 | Antimicrobial activity against Pseudomonas aeruginosa 16D2 tracheal isolates from mechanically ventilated chronic respiratory insufficiency patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID567287 | Antimicrobial activity against Acinetobacter baumannii beta-lactamase by Etest method | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | Extended-spectrum cephalosporinase in Acinetobacter baumannii. |
| AID405081 | Antimicrobial activity against Escherichia coli CAG12177 by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | Biochemical characterization of PER-2 and genetic environment of blaPER-2. |
| AID534907 | Antimicrobial activity against Citrobacter with derepressed AmpC beta-lactamsae assessed as susceptible isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activity of doripenem, a carbapenem for the treatment of challenging infections caused by gram-negative bacteria, against recent clinical isolates from the United States. |
| AID1373297 | Antimicrobial activity against Escherichia coli expressing beta-lactamase VEB-7 by CLSI broth microdilution method | 2018 | Bioorganic & medicinal chemistry letters, 02-15, Volume: 28, Issue:4 | Optimization of novel monobactams with activity against carbapenem-resistant Enterobacteriaceae - Identification of LYS228. |
| AID573402 | Antimicrobial activity against mucA::lox, mutS::lox-deficient Pseudomonas aeruginosa PAOMSAA biofilm harboring nfxB C89T mutant gene selected at 4 ug/ml of azithromycin after 6 passages by Etest method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Azithromycin in Pseudomonas aeruginosa biofilms: bactericidal activity and selection of nfxB mutants. |
| AID341597 | Antibacterial activity against sEscherichia coli GeneHogs harboring blaKPC-encoding plasmids | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8 | Emergence of KPC-2 and KPC-3 in carbapenem-resistant Klebsiella pneumoniae strains in an Israeli hospital. |
| AID534611 | Antimicrobial activity against Ceftazidime non-susceptible Enterobacteriaceae assessed as intermediate isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activity of doripenem, a carbapenem for the treatment of challenging infections caused by gram-negative bacteria, against recent clinical isolates from the United States. |
| AID556693 | Antimicrobial activity against multidrug resistant Enterobacter aerogenes ATCC 15038 harboring pDrive plasmid expressing ampC gene by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Occurrence of efflux mechanism and cephalosporinase variant in a population of Enterobacter aerogenes and Klebsiella pneumoniae isolates producing extended-spectrum beta-lactamases. |
| AID529579 | Ratio of Kcat to Km for Legionella gormanii ATCC 33297T beta-Lactamase FEZ-1 | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Functional diversity among metallo-beta-lactamases: characterization of the CAR-1 enzyme of Erwinia carotovora. |
| AID368541 | Ratio of Kcat to Km of Pseudomonas aeruginosa 4352 AmpC assessed as drug hydrolysis by spectrophotometry | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID545464 | Antimicrobial activity against Pseudomonas fluorescens assessed as percent susceptible isolates by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Susceptibility of gram-negative pathogens isolated from patients with complicated intra-abdominal infections in the United States, 2007-2008: results of the Study for Monitoring Antimicrobial Resistance Trends (SMART). |
| AID584558 | Antimicrobial activity against Acinetobacter lwoffii isolate E expressing beta-lactamase OXA-164 isolated from tracheal secretion of patient by vitek 2 system | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | In vivo selection of a missense mutation in adeR and conversion of the novel blaOXA-164 gene into blaOXA-58 in carbapenem-resistant Acinetobacter baumannii isolates from a hospitalized patient. |
| AID498824 | Antimicrobial activity against Citrobacter freundii SZ62 expressing IMP-4, TEM-1, CMY-2, qnrS1, aac(6')-Ib-cr by CLSI method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Phenotypic and genotypic characterization of Enterobacteriaceae with decreased susceptibility to carbapenems: results from large hospital-based surveillance studies in China. |
| AID531969 | Antibacterial activity against Klebsiella pneumoniae blood isolate A28008 PFGE pattern A expressing KPC-2, TEM-1, SHV-11, CTX-M-2 beta-lactamase by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | First report of KPC-2-producing Klebsiella pneumoniae strains in Brazil. |
| AID567733 | Antimicrobial activity against Pseudomonas aeruginosa OC 11492 by broth macrodilution method | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | Differential selection of single-step AmpC or efflux mutants of Pseudomonas aeruginosa by using cefepime, ceftazidime, or ceftobiprole. |
| AID528529 | Antimicrobial activity against penicillin-resistant Streptococcus agalactiae B12 by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | First molecular characterization of group B streptococci with reduced penicillin susceptibility. |
| AID528978 | Antimicrobial activity against methicillin-susceptible Staphylococcus aureus assessed as resistant isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Antimicrobial-resistant pathogens in intensive care units in Canada: results of the Canadian National Intensive Care Unit (CAN-ICU) study, 2005-2006. |
| AID573194 | Antimicrobial activity against Pseudomonas aeruginosa PAO1 A biofilm harboring duplication mutation at nucleotide 333 in nfxB gene selected at 0.5 ug/ml of azithromycin by Etest method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Azithromycin in Pseudomonas aeruginosa biofilms: bactericidal activity and selection of nfxB mutants. |
| AID1373312 | Antimicrobial activity against Escherichia coli expressing beta-lactamase CMY-2 by CLSI broth microdilution method | 2018 | Bioorganic & medicinal chemistry letters, 02-15, Volume: 28, Issue:4 | Optimization of novel monobactams with activity against carbapenem-resistant Enterobacteriaceae - Identification of LYS228. |
| AID285689 | Antimicrobial susceptibility of carbapenem-resistant Pseudomonas aeruginosa PA4012 isolate expressing carbapenemase KPC2 | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | First identification of Pseudomonas aeruginosa isolates producing a KPC-type carbapenem-hydrolyzing beta-lactamase. |
| AID340734 | Antimicrobial activity against Escherichia coli HB101 harboring pBC-SK plasmid assessed as drug level at which microbial resistance was observed by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8 | Identification and characterization of a new metallo-beta-lactamase, IND-5, from a clinical isolate of Chryseobacterium indologenes. |
| AID508486 | Antimicrobial activity against Pseudomonas aeruginosa isolate BU-36178 producing metallo-beta-lactamase VIM2 by Etest | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Molecular epidemiology of metallo-beta-lactamase-producing Pseudomonas aeruginosa isolates from Norway and Sweden shows import of international clones and local clonal expansion. |
| AID560093 | Bactericidal activity against Escherichia coli isolate 5401 at 1/4 times MIC after 24 hrs by time kill analysis | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | In vitro activity of ceftaroline alone and in combination against clinical isolates of resistant gram-negative pathogens, including beta-lactamase-producing Enterobacteriaceae and Pseudomonas aeruginosa. |
| AID559268 | Antimicrobial activity against rifampin-resistant Escherichia coli J53 transconjugated with Providencia stuartii Ps5 expressing beta-lactamase PER-1 by disk diffusion method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Emergence of extended-spectrum beta-lactamase PER-1 in Proteus vulgaris and Providencia stuartii isolates from Algiers, Algeria. |
| AID556698 | Antimicrobial activity against multidrug resistant Escherichia coli ATCC 35218 by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Occurrence of efflux mechanism and cephalosporinase variant in a population of Enterobacter aerogenes and Klebsiella pneumoniae isolates producing extended-spectrum beta-lactamases. |
| AID625280 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for cholecystitis | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID498886 | Antimicrobial activity against Pseudomonas aeruginosa OC 4354 assessed as inhibition of growth by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vivo activity of ceftobiprole in murine skin infections due to Staphylococcus aureus and Pseudomonas aeruginosa. |
| AID530348 | Antimicrobial activity against azide-resistant Escherichia coli J53 by disk diffusion method | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Plasmid-mediated quinolone resistance pump QepA2 in an Escherichia coli isolate from France. |
| AID583652 | Antibacterial activity against Escherichia coli TOP10 expressing metallo-beta-lactamase NDM-1 | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Emergence of metallo-β-lactamase NDM-1-producing multidrug-resistant Escherichia coli in Australia. |
| AID283529 | Antibacterial activity against Pseudomonas aeruginosa PAO1 by microdilution method | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3 | Cumulative effects of several nonenzymatic mechanisms on the resistance of Pseudomonas aeruginosa to aminoglycosides. |
| AID563974 | Activity of Klebsiella pneumoniae 05-560 beta-lactamase IMP1 by spectrophotometry | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Characterization of a new metallo-beta-lactamase gene, bla(NDM-1), and a novel erythromycin esterase gene carried on a unique genetic structure in Klebsiella pneumoniae sequence type 14 from India. |
| AID761209 | Antibacterial activity against Escherichia coli expressing ESBL by broth microdilution method | 2013 | Journal of medicinal chemistry, Jul-11, Volume: 56, Issue:13 | Pyridone-conjugated monobactam antibiotics with gram-negative activity. |
| AID546162 | Antimicrobial activity against Pseudomonas aeruginosa isolate Pae-beta-02 with PDC-1 variant by Etest | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Extended-spectrum cephalosporinases in Pseudomonas aeruginosa. |
| AID1373304 | Antimicrobial activity against Escherichia coli expressing beta-lactamase GIM-1 by CLSI broth microdilution method | 2018 | Bioorganic & medicinal chemistry letters, 02-15, Volume: 28, Issue:4 | Optimization of novel monobactams with activity against carbapenem-resistant Enterobacteriaceae - Identification of LYS228. |
| AID368500 | Ratio of Kcat to Km of Klebsiella oxytoca beta-lactamase K1 assessed as drug hydrolysis by spectrophotometry relative to cephaloridine | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID549335 | Antimicrobial activity against Escherichia coli isolate Z1 harboring bla CTX-M-3a gene by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | blaCTX-M genes in escherichia coli strains from Croatian Hospitals are located in new (blaCTX-M-3a) and widely spread (blaCTX-M-3a and blaCTX-M-15) genetic structures. |
| AID587524 | Antimicrobial activity against carbapenemases KPC-producing Klebsiella pneumoniae VA-361 infected in sc dosed CD-1 mouse in presence of 4 ug/ml NXL104 beta-lactamase inhibitor | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1 | Evaluation of ceftazidime and NXL104 in two murine models of infection due to KPC-producing Klebsiella pneumoniae. |
| AID556667 | Antimicrobial activity against multidrug resistant Enterobacter aerogenes isolate 22 by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Occurrence of efflux mechanism and cephalosporinase variant in a population of Enterobacter aerogenes and Klebsiella pneumoniae isolates producing extended-spectrum beta-lactamases. |
| AID324870 | Antimicrobial activity against Acinetobacter baumannii B46 in presence of efflux pump inhibitor phenyl-arginine-beta-naphthylamide by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Tigecycline Efflux as a Mechanism for Nonsusceptibility in Acinetobacter baumannii. |
| AID372607 | Antibacterial activity against Escherichia coli DH5alpha producing beta-lactamase TEM-158 by microdilution method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | TEM-158 (CMT-9), a new member of the CMT-type extended-spectrum beta-lactamases. |
| AID584557 | Antimicrobial activity against Acinetobacter lwoffii isolate D expressing beta-lactamase OXA-164 isolated from tracheal secretion of patient by vitek 2 system | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | In vivo selection of a missense mutation in adeR and conversion of the novel blaOXA-164 gene into blaOXA-58 in carbapenem-resistant Acinetobacter baumannii isolates from a hospitalized patient. |
| AID324856 | Antimicrobial activity against Acinetobacter baumannii A24 in presence of efflux pump inhibitor phenyl-arginine-beta-naphthylamide by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Tigecycline Efflux as a Mechanism for Nonsusceptibility in Acinetobacter baumannii. |
| AID533757 | Antibacterial activity against SHV-2a producing Pseudomonas aeruginosa isolate P60 exhibiting PFGE H pattern by 2-fold agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | Nationwide investigation of extended-spectrum beta-lactamases, metallo-beta-lactamases, and extended-spectrum oxacillinases produced by ceftazidime-resistant Pseudomonas aeruginosa strains in France. |
| AID587727 | Antimicrobial activity against Escherichia coli DH5alpha carrying Pseudomonas aeruginosa strain PS 297 IMP-18-pLBII after 18 hrs by microdilution broth method | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1 | Genetic context and biochemical characterization of the IMP-18 metallo-beta-lactamase identified in a Pseudomonas aeruginosa isolate from the United States. |
| AID508483 | Antimicrobial activity against Pseudomonas aeruginosa isolate K34-7 producing metallo-beta-lactamase VIM2 by Etest | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Molecular epidemiology of metallo-beta-lactamase-producing Pseudomonas aeruginosa isolates from Norway and Sweden shows import of international clones and local clonal expansion. |
| AID584099 | Antibacterial activity against colistin-resistant Acinetobacter baumannii ATCC 19606R exhibiting complete loss of lipopolysaccharide production by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | Colistin resistance in Acinetobacter baumannii is mediated by complete loss of lipopolysaccharide production. |
| AID405640 | Inhibition of bocillin FL binding to Escherichia coli MC4100 penicillin-binding protein 2 | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | Binding of ceftobiprole and comparators to the penicillin-binding proteins of Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Streptococcus pneumoniae. |
| AID425652 | Total body clearance in human | 2009 | Journal of medicinal chemistry, Aug-13, Volume: 52, Issue:15 | Physicochemical determinants of human renal clearance. |
| AID522387 | Antimicrobial activity against Escherichia coli TOP10 | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Genetic and biochemical characterization of TRU-1, the endogenous class C beta-lactamase from Aeromonas enteropelogenes. |
| AID340733 | Antimicrobial activity against Chryseobacterium indologenes NF16 isolate assessed as drug level at which microbial resistance was observed by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8 | Identification and characterization of a new metallo-beta-lactamase, IND-5, from a clinical isolate of Chryseobacterium indologenes. |
| AID541004 | Antimicrobial activity against Burkholderia cenocepacia 07-34 expressing beta-lactamase PenB1 | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Naturally occurring Class A ss-lactamases from the Burkholderia cepacia complex. |
| AID556666 | Antimicrobial activity against multidrug resistant Enterobacter aerogenes isolate 21 by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Occurrence of efflux mechanism and cephalosporinase variant in a population of Enterobacter aerogenes and Klebsiella pneumoniae isolates producing extended-spectrum beta-lactamases. |
| AID285271 | Activity of Escherichia coli BL21(DE3) beta-lactamase TEM1 | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Evolution of TEM-type enzymes: biochemical and genetic characterization of two new complex mutant TEM enzymes, TEM-151 and TEM-152, from a single patient. |
| AID524745 | Antimicrobial activity against Escherichia coli GB20 harboring V27A, Q38R, P167S mutation in beta lactamase CTX-M-3 by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Mutational events in cefotaximase extended-spectrum beta-lactamases of the CTX-M-1 cluster involved in ceftazidime resistance. |
| AID559275 | Antimicrobial activity against rifampin-resistant Escherichia coli J53 transconjugated with Proteus vulgaris Pv7 expressing beta-lactamase PER-1 by Etest | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Emergence of extended-spectrum beta-lactamase PER-1 in Proteus vulgaris and Providencia stuartii isolates from Algiers, Algeria. |
| AID1318928 | Antibacterial activity against multidrug-resistant/tobramycin-susceptible Pseudomonas aeruginosa isolate 86067 | 2016 | Journal of medicinal chemistry, 09-22, Volume: 59, Issue:18 | Hybrid Antibiotic Overcomes Resistance in P. aeruginosa by Enhancing Outer Membrane Penetration and Reducing Efflux. |
| AID531605 | Activity of Escherichia coli beta-lactamase SHV-11 | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Molecular and biochemical characterization of SHV-56, a novel inhibitor-resistant beta-lactamase from Klebsiella pneumoniae. |
| AID1373291 | Antimicrobial activity against Escherichia coli expressing beta-lactamase PER-2 by CLSI broth microdilution method | 2018 | Bioorganic & medicinal chemistry letters, 02-15, Volume: 28, Issue:4 | Optimization of novel monobactams with activity against carbapenem-resistant Enterobacteriaceae - Identification of LYS228. |
| AID567317 | Antimicrobial activity against Proteus mirabilis TUM4660 by broth dilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Chromosomally encoded blaCMY-2 located on a novel SXT/R391-related integrating conjugative element in a Proteus mirabilis clinical isolate. |
| AID535648 | Antimicrobial activity against aac(6')-Ib-cr-positive Escherichia coli FJ3 harboring GyrA S83L, ParC S80R mutant, wild-type GyrB and qnrB genes by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | High prevalence of plasmid-mediated quinolone resistance genes qnr and aac(6')-Ib-cr in clinical isolates of Enterobacteriaceae from nine teaching hospitals in China. |
| AID373036 | Antimicrobial activity against imipenem and meropenem-resistant Acinetobacter baumannii isolate BJ52 by CLSI agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Molecular epidemiology of clinical isolates of carbapenem-resistant Acinetobacter spp. from Chinese hospitals. |
| AID405639 | Inhibition of bocillin FL binding to Escherichia coli MC4100 penicillin-binding protein 3 | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | Binding of ceftobiprole and comparators to the penicillin-binding proteins of Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Streptococcus pneumoniae. |
| AID547755 | Antimicrobial activity against invasive Streptococcus intermedius obtained from non-cystic fibrosis patient assessed as non-susceptible isolates grown on mueller-Hinton blood agar at 30 ug/ml after 24 hrs at 37 degC by disk diffusion method in presence of | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Macrolide and clindamycin resistance in Streptococcus milleri group isolates from the airways of cystic fibrosis patients. |
| AID562740 | Antimicrobial activity against Escherichia coli DH5[alpha] harboring pBC-CTX-M-15 plasmid by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | New variant of CTX-M-type extended-spectrum beta-lactamases, CTX-M-71, with a Gly238Cys substitution in a Klebsiella pneumoniae isolate from Bulgaria. |
| AID576317 | Antimicrobial activity against ESBL-negative Klebsiella pneumoniae 30018 harboring porin OmpK35 gene by Etest | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | An ertapenem-resistant extended-spectrum-beta-lactamase-producing Klebsiella pneumoniae clone carries a novel OmpK36 porin variant. |
| AID535134 | Antimicrobial activity against Ceftazidime susceptible Pseudomonas aeruginosa assessed as susceptible isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activity of doripenem, a carbapenem for the treatment of challenging infections caused by gram-negative bacteria, against recent clinical isolates from the United States. |
| AID521830 | Antimicrobial activity against Streptococcus pneumoniae isolated from meningitis patient assessed as percent susceptible isolates by CLSI method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Clonal spread of highly beta-lactam-resistant Streptococcus pneumoniae isolates in Taiwan. |
| AID529303 | Antimicrobial activity against Acinetobacter genospecies 3 isolate Ac057 expressing beta-lactamase Oxa-58 by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Characterization of the carbapenem-hydrolyzing oxacillinase oxa-58 in an Acinetobacter genospecies 3 clinical isolate. |
| AID565201 | Antimicrobial activity against Klebsiella pneumoniae isolate T-1504 expressing VIM-1 and KPC-2 genes by microdilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Emerging Klebsiella pneumoniae isolates coproducing KPC-2 and VIM-1 carbapenemases. |
| AID279184 | Antibacterial activity against Escherichia coli DH10B | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2 | Novel Ambler class A beta-lactamase LAP-1 and its association with the plasmid-mediated quinolone resistance determinant QnrS1. |
| AID528824 | Antimicrobial activity against carbapenem-resistant Pseudomonas aeruginosa assessed as resistant isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Antimicrobial-resistant pathogens in intensive care units in Canada: results of the Canadian National Intensive Care Unit (CAN-ICU) study, 2005-2006. |
| AID545449 | Antimicrobial activity against extended-spectrum beta-lactamase-positive Klebsiella oxytoca assessed as percent susceptible isolates by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Susceptibility of gram-negative pathogens isolated from patients with complicated intra-abdominal infections in the United States, 2007-2008: results of the Study for Monitoring Antimicrobial Resistance Trends (SMART). |
| AID543419 | Antimicrobial activity against rifampicin-resistant Escherichia coli X1037 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Novel chimeric beta-lactamase CTX-M-64, a hybrid of CTX-M-15-like and CTX-M-14 beta-lactamases, found in a Shigella sonnei strain resistant to various oxyimino-cephalosporins, including ceftazidime. |
| AID373205 | Antimicrobial activity against Bacillus clausii T by agar-dilution technique | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Molecular and biochemical characterization of the chromosome-encoded class A beta-lactamase BCL-1 from Bacillus clausii. |
| AID499123 | Antimicrobial activity against Pseudomonas aeruginosa OC 4354 infected in immunocompromized SKH1 mouse assessed as lesion volume at 6.2 mg/kg/day, sc measured after 48 hrs postinfection (Rvb = 2195 mm3) | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vivo activity of ceftobiprole in murine skin infections due to Staphylococcus aureus and Pseudomonas aeruginosa. |
| AID573197 | Antimicrobial activity against mucA::lox-deficient Pseudomonas aeruginosa PAOMAB biofilm harboring nfxB G125T mutant gene selected at 0.5 ug/ml of azithromycin after 1 passages by Etest method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Azithromycin in Pseudomonas aeruginosa biofilms: bactericidal activity and selection of nfxB mutants. |
| AID584837 | Antimicrobial activity against Escherichia coli DH10B harboring recombinant Aeromonas allosaccharophila AL-1 beta-lactamase PER1 by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | PER-6, an extended-spectrum beta-lactamase from Aeromonas allosaccharophila. |
| AID573342 | Antibacterial activity against ceftazidime-susceptible Citrobacter freundii assessed as resistant isolates by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID1231668 | Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 assessed as inhibition of bacterial growth incubated for 72 hrs by CLSI based method | 2015 | Bioorganic & medicinal chemistry, Jul-01, Volume: 23, Issue:13 | Colloidal and antibacterial properties of novel triple-headed, double-tailed amphiphiles: exploring structure-activity relationships and synergistic mixtures. |
| AID394690 | Antibacterial activity against beta-lactams resistant Pseudomonas aeruginosa isolate expressing AmpC, PSE-1, MexXY-OprM pump by macrodilution technique | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10 | Pseudomonas aeruginosa may accumulate drug resistance mechanisms without losing its ability to cause bloodstream infections. |
| AID561671 | Antimicrobial activity against Pseudomonas aeruginosa isolate OC16830 harboring plasmid JAK16 expressing mexXY gene by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Effect of MexXY overexpression on ceftobiprole susceptibility in Pseudomonas aeruginosa. |
| AID369641 | Antibacterial activity against Acinetobacter baumannii B clone by Etest method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Molecular epidemiology of imipenem-resistant Acinetobacter haemolyticus and Acinetobacter baumannii isolates carrying plasmid-mediated OXA-40 from a Portuguese hospital. |
| AID533879 | Antibacterial activity against amoxicillin-resistant Streptococcus pneumoniae assessed as percent susceptible isolates by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | In vitro activity of ceftaroline against Streptococcus pneumoniae isolates exhibiting resistance to penicillin, amoxicillin, and cefotaxime. |
| AID554441 | Ratio of MIC for Pseudomonas aeruginosa 2998 to MIC for Pseudomonas aeruginosa PAO1 | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Efflux unbalance in Pseudomonas aeruginosa isolates from cystic fibrosis patients. |
| AID285612 | Antimicrobial activity against Pseudomonas aeruginosa 65.68-4 tracheal isolates from mechanically ventilated tuberculosis patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID519013 | Ratio of Kcat to Km for Beta-lactamase TEM-10 | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | E240V substitution increases catalytic efficiency toward ceftazidime in a new natural TEM-type extended-spectrum beta-lactamase, TEM-149, from Enterobacter aerogenes and Serratia marcescens clinical isolates. |
| AID546430 | Ratio of Kcat to Km for Pseudomonas aeruginosa PDC-1 by spectrophotometer | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Extended-spectrum cephalosporinases in Pseudomonas aeruginosa. |
| AID252618 | Mean lysis diameter of wild type Enterobacter aerogenes EA289 with OmpF by standard disk diffusion method on MH agar | 2005 | Journal of medicinal chemistry, Mar-10, Volume: 48, Issue:5 | Beta-lactam screening by specific residues of the OmpF eyelet. |
| AID583030 | Antimicrobial activity against Escherichia coli TOP10 transformed with Enterobacter asburiae CIP 105006 plasmid carrying ACT-1 by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Phenotypic and biochemical comparison of the carbapenem-hydrolyzing activities of five plasmid-borne AmpC β-lactamases. |
| AID556671 | Antimicrobial activity against multidrug resistant Enterobacter aerogenes isolate 26 by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Occurrence of efflux mechanism and cephalosporinase variant in a population of Enterobacter aerogenes and Klebsiella pneumoniae isolates producing extended-spectrum beta-lactamases. |
| AID761218 | Antibacterial activity against Pseudomonas aeruginosa 1042-06 by broth microdilution method | 2013 | Journal of medicinal chemistry, Jul-11, Volume: 56, Issue:13 | Pyridone-conjugated monobactam antibiotics with gram-negative activity. |
| AID565539 | Antibacterial activity against mexB, mexY and mexD expressing Pseudomonas aeruginosa isolate Paebeta-03 harboring A residue at 105 position in PDC- 2 and polymorphic OprD gene by Etest method in presence of cloxacillin | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Molecular epidemiology and mechanisms of carbapenem resistance in Pseudomonas aeruginosa. |
| AID584100 | Antibacterial activity against Acinetobacter baumannii ATCC 19606 by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | Colistin resistance in Acinetobacter baumannii is mediated by complete loss of lipopolysaccharide production. |
| AID531600 | Antimicrobial activity against Escherichia coli JM109 harboring pE1 plasmid expressing beta-lactamase SHV-11 by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Molecular and biochemical characterization of SHV-56, a novel inhibitor-resistant beta-lactamase from Klebsiella pneumoniae. |
| AID521352 | Antimicrobial activity against Streptococcus pneumoniae ATCC BAA-612 | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Highly variable penicillin resistance determinants PBP 2x, PBP 2b, and PBP 1a in isolates of two Streptococcus pneumoniae clonal groups, Poland 23F-16 and Poland 6B-20. |
| AID1079944 | Benign tumor, proven histopathologically. Value is number of references indexed. [column 'T.BEN' in source] | |||
| AID583020 | Antimicrobial activity against OmpC/OmpF porin deficient Escherichia coli HB4 transformed with Enterobacter asburiae CIP 105006 plasmid carrying ACT-1 by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Phenotypic and biochemical comparison of the carbapenem-hydrolyzing activities of five plasmid-borne AmpC β-lactamases. |
| AID498810 | Antimicrobial activity against carbapenem-resistant Escherichia coli ZJ86 deficient in KPC-2, TEM-1, ompC by CLSI method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Phenotypic and genotypic characterization of Enterobacteriaceae with decreased susceptibility to carbapenems: results from large hospital-based surveillance studies in China. |
| AID523891 | Antimicrobial activity against Acinetobacter baumannii ATCC 15151 harboring plasmid AT801 by Etest | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Genetic basis of multidrug resistance in Acinetobacter clinical isolates in Taiwan. |
| AID285660 | Antimicrobial activity against Pseudomonas aeruginosa 19F1 tracheal isolates from mechanically ventilated chronic respiratory insufficiency patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID499067 | Antimicrobial activity against carbapenem-resistant Enterobacter cloacae NJ89 deficient in CTX-M-14, ompC/F by CLSI method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Phenotypic and genotypic characterization of Enterobacteriaceae with decreased susceptibility to carbapenems: results from large hospital-based surveillance studies in China. |
| AID571688 | Antimicrobial activity against ISAba1 linked with the blaOXA-51-type beta-lactamase harboring Acinetobacter baumannii alpha clonal group isolate 1 expressing ampC, ompA, adeB, adeM by Etest method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Correlation of antimicrobial resistance with beta-lactamases, the OmpA-like porin, and efflux pumps in clinical isolates of Acinetobacter baumannii endemic to New York City. |
| AID573203 | Antimicrobial activity against mutS::lox-deficient Pseudomonas aeruginosa PAOMSA biofilm harboring nfxB T86C mutant gene selected at 4 ug/ml of azithromycin after 3 passages by Etest method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Azithromycin in Pseudomonas aeruginosa biofilms: bactericidal activity and selection of nfxB mutants. |
| AID495658 | Antimicrobial activity against Escherichia coli TOP10 by solid agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | BEL-2, an extended-spectrum beta-lactamase with increased activity toward expanded-spectrum cephalosporins in Pseudomonas aeruginosa. |
| AID285606 | Antimicrobial activity against Pseudomonas aeruginosa 2A7 tracheal isolates from mechanically ventilated tuberculosis patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID522568 | Antimicrobial activity against Escherichia coli isolate 4009273 with AmpC beta-lactamase S287N mutation | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Occurrence of ST23 complex phylogroup A Escherichia coli isolates producing extended-spectrum AmpC beta-lactamase in a French hospital. |
| AID567309 | Antimicrobial activity against SHV-12 ESBL producing Pseudomonas aeruginosa isolate 2207 isolated from burn patient by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Acquisition of a transposon encoding extended-spectrum beta-lactamase SHV-12 by Pseudomonas aeruginosa isolates during the clinical course of a burn patient. |
| AID534905 | Antimicrobial activity against Citrobacter with nonderepressed AmpC beta-lactamsae assessed as intermediate isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activity of doripenem, a carbapenem for the treatment of challenging infections caused by gram-negative bacteria, against recent clinical isolates from the United States. |
| AID571900 | Antimicrobial activity against ISAba1 linked with the blaOXA-51-type beta-lactamase harboring Acinetobacter baumannii beta clonal group isolate 14 expressing ompA, adeB, adeM, aacA4, blaSHV-5 by Etest method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Correlation of antimicrobial resistance with beta-lactamases, the OmpA-like porin, and efflux pumps in clinical isolates of Acinetobacter baumannii endemic to New York City. |
| AID573188 | Antimicrobial activity against mucA::lox-deficient Pseudomonas aeruginosa PAOMA biofilm by Etest method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Azithromycin in Pseudomonas aeruginosa biofilms: bactericidal activity and selection of nfxB mutants. |
| AID508731 | Antibacterial activity against carbapenem-resistant Pseudomonas aeruginosa isolate 3D2 GM2 harboring acquired beta-lactamase BEL-3 by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2 | Activity of a new antipseudomonal cephalosporin, CXA-101 (FR264205), against carbapenem-resistant and multidrug-resistant Pseudomonas aeruginosa clinical strains. |
| AID587529 | Antimicrobial activity against carbapenemases KPC-producing Klebsiella pneumoniae VA-406 infected in sc dosed CD-1 mouse in presence of 2 ug/ml NXL104 beta-lactamase inhibitor | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1 | Evaluation of ceftazidime and NXL104 in two murine models of infection due to KPC-producing Klebsiella pneumoniae. |
| AID528834 | Antimicrobial activity against CTX-M ESBL producing Escherichia coli assessed as resistant isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Antimicrobial-resistant pathogens in intensive care units in Canada: results of the Canadian National Intensive Care Unit (CAN-ICU) study, 2005-2006. |
| AID524004 | Selectivity ratio of MIC for Acinetobacter baumannii ATCC 15151 harboring ISAba1-blaOXA-23 gene to MIC for Acinetobacter baumannii ATCC 15151 harboring ISAba1-blaOXA-66 gene | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Genetic basis of multidrug resistance in Acinetobacter clinical isolates in Taiwan. |
| AID368510 | Activity of Serratia marcescens SME3 assessed as drug hydrolysis by spectrophotometry relative to cephaloridine | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID534663 | Antimicrobial activity against ESBL producing Proteus mirabilis by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activity of doripenem, a carbapenem for the treatment of challenging infections caused by gram-negative bacteria, against recent clinical isolates from the United States. |
| AID341106 | Antibacterial activity against metallo-beta-lactamase VIM12 expressing Escherichia coli 28 isolate from decubitus ulcer infection patient by Etest | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8 | First occurrence of an Escherichia coli clinical isolate producing the VIM-1/VIM-2 hybrid metallo-beta-lactamase VIM-12. |
| AID530600 | Antibacterial activity against Aeromonas sp. isolate A72 by Etest | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Expanded-spectrum beta-lactamase PER-1 in an environmental Aeromonas media isolate from Switzerland. |
| AID1592958 | Antibacterial activity against multi-drug resistant Escherichia coli NMI 3898/15 assessed as reduction in microbial growth incubated for 20 hrs | 2019 | European journal of medicinal chemistry, Apr-15, Volume: 168 | Microwave-assisted solid-phase synthesis of antisense acpP peptide nucleic acid-peptide conjugates active against colistin- and tigecycline-resistant E. coli and K. pneumoniae. |
| AID557204 | Volume of distribution in critically ill patient with normal renal function at 2 mg/kg administered as single bolus dose | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Population pharmacokinetics of high-dose, prolonged-infusion cefepime in adult critically ill patients with ventilator-associated pneumonia. |
| AID584097 | Antibacterial activity against colistin-resistant Acinetobacter baumannii ATCC 19606R harboring pAL840 plasmid encoding intact lpxA gene by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | Colistin resistance in Acinetobacter baumannii is mediated by complete loss of lipopolysaccharide production. |
| AID572146 | Antimicrobial activity against ISAba1 linked with the blaOXA-51-type beta-lactamase harboring Acinetobacter baumannii unique clonal group isolate 40 expressing ampC, ompA, adeB, adeM, aadA1, aacA4, aacC2, blaSHV-5 by Etest method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Correlation of antimicrobial resistance with beta-lactamases, the OmpA-like porin, and efflux pumps in clinical isolates of Acinetobacter baumannii endemic to New York City. |
| AID373046 | Antimicrobial activity against imipenem and meropenem-resistant Acinetobacter baumannii isolate ZS5 by CLSI agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Molecular epidemiology of clinical isolates of carbapenem-resistant Acinetobacter spp. from Chinese hospitals. |
| AID522002 | Antimicrobial activity against Escherichia coli isolate J53 harboring p6A containing beta-lactamase OXA-48 located within transposon Tn1999 by Etest method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Spread of OXA-48-encoding plasmid in Turkey and beyond. |
| AID573344 | Antibacterial activity against ceftazidime-nonsusceptible Citrobacter freundii assessed as susceptible isolates by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID1373317 | Antimicrobial activity against Escherichia coli expressing beta-lactamase Oxa-23 by CLSI broth microdilution method | 2018 | Bioorganic & medicinal chemistry letters, 02-15, Volume: 28, Issue:4 | Optimization of novel monobactams with activity against carbapenem-resistant Enterobacteriaceae - Identification of LYS228. |
| AID558790 | Antimicrobial activity against Enterobacter cloacae assessed as percent susceptible isolates by CLSI method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Emergence of high levels of extended-spectrum-beta-lactamase-producing gram-negative bacilli in the Asia-Pacific region: data from the Study for Monitoring Antimicrobial Resistance Trends (SMART) program, 2007. |
| AID405641 | Inhibition of bocillin FL binding to Escherichia coli MC4100 penicillin-binding protein 1b | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | Binding of ceftobiprole and comparators to the penicillin-binding proteins of Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Streptococcus pneumoniae. |
| AID564452 | Antimicrobial activity against Pseudomonas aeruginosa isolate 944 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | In vivo efficacy of 1- and 2-gram human simulated prolonged infusions of doripenem against Pseudomonas aeruginosa. |
| AID373032 | Antimicrobial activity against imipenem and meropenem-resistant Acinetobacter baumannii isolate FW-F1 by CLSI agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Molecular epidemiology of clinical isolates of carbapenem-resistant Acinetobacter spp. from Chinese hospitals. |
| AID556646 | Antimicrobial activity against multidrug resistant Enterobacter aerogenes isolate 1 by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Occurrence of efflux mechanism and cephalosporinase variant in a population of Enterobacter aerogenes and Klebsiella pneumoniae isolates producing extended-spectrum beta-lactamases. |
| AID520711 | Antibacterial activity against Escherichia coli TOP10 harboring pOXA-58 | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Carbapenem-resistant Acinetobacter baumannii isolates from Tunisia producing the OXA-58-like carbapenem-hydrolyzing oxacillinase OXA-97. |
| AID660265 | Antimicrobial activity against wild type Escherichia coli expressing AcrAB-TolC efflux pump | 2012 | European journal of medicinal chemistry, Jun, Volume: 52 | Computational analysis of structure-based interactions and ligand properties can predict efflux effects on antibiotics. |
| AID524593 | Antimicrobial activity against multidrug-resistant Klebsiella pneumoniae isolate Kpn-DK2 by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | KPC-producing extreme drug-resistant Klebsiella pneumoniae isolate from a patient with diabetes mellitus and chronic renal failure on hemodialysis in South Korea. |
| AID761217 | Antibacterial activity against Pseudomonas aeruginosa 1091-05 by broth microdilution method | 2013 | Journal of medicinal chemistry, Jul-11, Volume: 56, Issue:13 | Pyridone-conjugated monobactam antibiotics with gram-negative activity. |
| AID535897 | Antimicrobial activity against aac(6')-Ib-cr-positive Citrobacter freundii JS33 harboring GyrA T83I mutant, wild-type ParC, GyrB, qnrA and qnrB genes by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | High prevalence of plasmid-mediated quinolone resistance genes qnr and aac(6')-Ib-cr in clinical isolates of Enterobacteriaceae from nine teaching hospitals in China. |
| AID520971 | Antibacterial activity against Klebsiella pneumoniae 633 by Etest method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Genetic structures at the origin of acquisition of the beta-lactamase bla KPC gene. |
| AID498821 | Antimicrobial activity against Klebsiella pneumoniae WH76T expressing IMP-4, TEM-1, CTX-M-3, qnrS1 by CLSI method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Phenotypic and genotypic characterization of Enterobacteriaceae with decreased susceptibility to carbapenems: results from large hospital-based surveillance studies in China. |
| AID373028 | Antimicrobial activity against imipenem and meropenem-resistant Acinetobacter baumannii isolate PU86 by CLSI agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Molecular epidemiology of clinical isolates of carbapenem-resistant Acinetobacter spp. from Chinese hospitals. |
| AID495518 | Antibacterial activity against multidrug-resistant Acinetobacter baumannii BM4676 by antimicrobial susceptibility assay | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Screening and quantification of the expression of antibiotic resistance genes in Acinetobacter baumannii with a microarray. |
| AID563157 | Antibacterial activity against Pseudomonas aeruginosa isolate 213BR by Etest | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | Involvement of pmrAB and phoPQ in polymyxin B adaptation and inducible resistance in non-cystic fibrosis clinical isolates of Pseudomonas aeruginosa. |
| AID373025 | Antimicrobial activity against imipenem and meropenem-resistant Acinetobacter baumannii isolate PU73 by CLSI agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Molecular epidemiology of clinical isolates of carbapenem-resistant Acinetobacter spp. from Chinese hospitals. |
| AID405427 | Antibacterial activity against Pseudomonas aeruginosa PAO1 by Etest | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | Influence of high mutation rates on the mechanisms and dynamics of in vitro and in vivo resistance development to single or combined antipseudomonal agents. |
| AID565280 | Antibacterial activity against Pseudomonas aeruginosa PAO1 by Etest method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Nosocomial spread of colistin-only-sensitive sequence type 235 Pseudomonas aeruginosa isolates producing the extended-spectrum beta-lactamases GES-1 and GES-5 in Spain. |
| AID533762 | Antibacterial activity against OXA-2 and OXA-19 producing Pseudomonas aeruginosa isolate P66 exhibiting PFGE C pattern by 2-fold agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | Nationwide investigation of extended-spectrum beta-lactamases, metallo-beta-lactamases, and extended-spectrum oxacillinases produced by ceftazidime-resistant Pseudomonas aeruginosa strains in France. |
| AID576308 | Antimicrobial activity against ESBL-positive Klebsiella pneumoniae 29459 harboring porin OmpK36 gene by Etest | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | An ertapenem-resistant extended-spectrum-beta-lactamase-producing Klebsiella pneumoniae clone carries a novel OmpK36 porin variant. |
| AID546173 | Antimicrobial activity against AmpC overproducing Pseudomonas aeruginosa isolate Pae-beta-13 with PDC-2 variant by Etest | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Extended-spectrum cephalosporinases in Pseudomonas aeruginosa. |
| AID405085 | Ratio of Kcat to Km of Citrobacter freundii PER2 beta lactamase | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | Biochemical characterization of PER-2 and genetic environment of blaPER-2. |
| AID368513 | Activity of Pseudomonas aeruginosa VIM2 assessed as drug hydrolysis by spectrophotometry relative to cephaloridine | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID368322 | Antibacterial activity against Escherichia coli 11732 producing beta lactamase CTX-M-15 by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID549337 | Antimicrobial activity against Escherichia coli ATCC 25922 harboring bla CTX-M-3a gene by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | blaCTX-M genes in escherichia coli strains from Croatian Hospitals are located in new (blaCTX-M-3a) and widely spread (blaCTX-M-3a and blaCTX-M-15) genetic structures. |
| AID535145 | Antimicrobial activity against imipenem non-susceptible Pseudomonas aeruginosa assessed as resistant isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activity of doripenem, a carbapenem for the treatment of challenging infections caused by gram-negative bacteria, against recent clinical isolates from the United States. |
| AID285690 | Antimicrobial susceptibility of carbapenem-resistant Pseudomonas aeruginosa PA4036 isolate expressing carbapenemase KPC2 | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | First identification of Pseudomonas aeruginosa isolates producing a KPC-type carbapenem-hydrolyzing beta-lactamase. |
| AID428271 | Antimicrobial activity against Klebsiella sp. assessed as resistant isolates by CLSI breakpoint assay | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | Antimicrobial activities of tigecycline and other broad-spectrum antimicrobials tested against serine carbapenemase- and metallo-beta-lactamase-producing Enterobacteriaceae: report from the SENTRY Antimicrobial Surveillance Program. |
| AID544488 | Antibacterial activity against Pseudomonas aeruginosa PR100 harboring beta-lactamase KPC-2 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Phenotypic and enzymatic comparative analysis of the novel KPC variant KPC-5 and its evolutionary variants, KPC-2 and KPC-4. |
| AID583638 | Cmin in febrile neutropenic patient at 2 g administered as 30 mins infusion every 8 hrs measured after 4 days by HPLC analysis | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | High cefepime plasma concentrations and neurological toxicity in febrile neutropenic patients with mild impairment of renal function. |
| AID528841 | Antimicrobial activity against penicillin-resistant Streptococcus pneumoniae isolated from ICU patient wound assessed as resistant isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Antimicrobial-resistant pathogens in intensive care units in Canada: results of the Canadian National Intensive Care Unit (CAN-ICU) study, 2005-2006. |
| AID531748 | Antibacterial activity against Pseudomonas aeruginosa EryR harboring pNF225 carrying nfxB by twofold serial dilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Resistance and virulence of Pseudomonas aeruginosa clinical strains overproducing the MexCD-OprJ efflux pump. |
| AID368731 | Ratio of Kcat to Km of Pseudomonas aeruginosa AmpC assessed as drug hydrolysis by spectrophotometry | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID518466 | Antimicrobial activity against Pseudomonas aeruginosa 621 assessed as number of passages required for MIC to rise above 4 times original MIC | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli. |
| AID546174 | Antimicrobial activity against AmpC overproducing Pseudomonas aeruginosa isolate Pae-beta-14 with PDC-2 variant by Etest | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Extended-spectrum cephalosporinases in Pseudomonas aeruginosa. |
| AID540948 | Antimicrobial activity against Escherichia coli DH5[alpha] harboring pB-c2 plasmid expressing cephalosporinase CMY-2 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | CMY-31 and CMY-36 cephalosporinases encoded by ColE1-like plasmids. |
| AID522574 | Antimicrobial activity against Escherichia coli isolate 8009389 with AmpC beta-lactamase H296P mutation | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Occurrence of ST23 complex phylogroup A Escherichia coli isolates producing extended-spectrum AmpC beta-lactamase in a French hospital. |
| AID532403 | Antibacterial activity against VIM-1 producing Pseudomonas aeruginosa clone E isolate VA-06X-29 by Etest method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | First countrywide survey of acquired metallo-beta-lactamases in gram-negative pathogens in Italy. |
| AID535894 | Antimicrobial activity against aac(6')-Ib-cr-negative Citrobacter freundii JN64T harboring qnrA gene by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | High prevalence of plasmid-mediated quinolone resistance genes qnr and aac(6')-Ib-cr in clinical isolates of Enterobacteriaceae from nine teaching hospitals in China. |
| AID565510 | Antibacterial activity against oprD, mexB, mexY and mexD expressing Pseudomonas aeruginosa isolate Paebeta-28 harboring A residue at 105 position in PDC- 7 by Etest method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Molecular epidemiology and mechanisms of carbapenem resistance in Pseudomonas aeruginosa. |
| AID573351 | Antibacterial activity against ceftazidime-nonsusceptible Enterobacter cloacae assessed as resistant isolates by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID372604 | Antibacterial activity against Escherichia coli BER1 producing TEM-158 by microdilution method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | TEM-158 (CMT-9), a new member of the CMT-type extended-spectrum beta-lactamases. |
| AID1474166 | Liver toxicity in human assessed as induction of drug-induced liver injury by measuring severity class index | 2016 | Drug discovery today, Apr, Volume: 21, Issue:4 | DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. |
| AID1225773 | Antibacterial activity against Enterobacter cloacae ECL1002 expressing Hyper AmpC by broth microdilution method | 2015 | Journal of medicinal chemistry, May-14, Volume: 58, Issue:9 | Discovery of a Cyclic Boronic Acid β-Lactamase Inhibitor (RPX7009) with Utility vs Class A Serine Carbapenemases. |
| AID559899 | Antimicrobial activity against Klebsiella pneumoniae 101A harboring beta-lactamase CMY-2 by Etest method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | First detection of plasmid-encoded blaOXY beta-lactamase. |
| AID559922 | Antibacterial activity against Escherichia coli TOP10 harboring recombinant plasmid RTG4-V49 by Etest method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Genetic and biochemical characterization of the first extended-spectrum CARB-type beta-lactamase, RTG-4, from Acinetobacter baumannii. |
| AID546175 | Antimicrobial activity against AmpC overproducing Pseudomonas aeruginosa isolate Pae-beta-15 with PDC-2 variant by Etest | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Extended-spectrum cephalosporinases in Pseudomonas aeruginosa. |
| AID522012 | Antimicrobial activity against Escherichia coli isolate J53 harboring pE containing beta-lactamase OXA-48 located within transposon Tn1999.2 by Etest method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Spread of OXA-48-encoding plasmid in Turkey and beyond. |
| AID373210 | Ratio of Kcat to Km for Bacillus clausii NR beta-lactamase BCL1 expressed in Escherichia coli BL21 (DE3) | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Molecular and biochemical characterization of the chromosome-encoded class A beta-lactamase BCL-1 from Bacillus clausii. |
| AID524923 | Antimicrobial activity against Escherichia coli MI1443 harboring V27A, Q38R, A77V, N114D, A140S, D240G, D288N mutations in beta lactamase CTX-M-32 by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Mutational events in cefotaximase extended-spectrum beta-lactamases of the CTX-M-1 cluster involved in ceftazidime resistance. |
| AID1361175 | Antibacterial activity against Pseudomonas aeruginosa SR27001 infected in Jcl:ICR mouse systemic infection model assessed as increase in mouse survival rate administered iv 1 to 5 hrs post infection measured over 7 days | 2018 | European journal of medicinal chemistry, Jul-15, Volume: 155 | Cefiderocol (S-649266), A new siderophore cephalosporin exhibiting potent activities against Pseudomonas aeruginosa and other gram-negative pathogens including multi-drug resistant bacteria: Structure activity relationship. |
| AID495910 | Antimicrobial activity in Escherichia coli TOP10 strain | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | VIM-19, a metallo-beta-lactamase with increased carbapenemase activity from Escherichia coli and Klebsiella pneumoniae. |
| AID529573 | Antimicrobial activity against Escherichia coli DH5alpha harboring plasmid pLBII carrying beta-lactamase CAR-1 gene after 24 hrs by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Functional diversity among metallo-beta-lactamases: characterization of the CAR-1 enzyme of Erwinia carotovora. |
| AID565512 | Antibacterial activity against oprD, mexB, mexY and mexD expressing Pseudomonas aeruginosa isolate Paebeta-30 harboring A residue at 105 position in PDC- 8 by Etest method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Molecular epidemiology and mechanisms of carbapenem resistance in Pseudomonas aeruginosa. |
| AID535169 | Antimicrobial activity against imipenem susceptible Acinetobacter assessed as intermediate isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activity of doripenem, a carbapenem for the treatment of challenging infections caused by gram-negative bacteria, against recent clinical isolates from the United States. |
| AID322324 | Antibacterial activity against Escherichia coli INSRA5924 isolates expressing CTX-M-32 and TEM-1B enzymes by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Spread of extended-spectrum beta-lactamase CTX-M-producing escherichia coli clinical isolates in community and nosocomial environments in Portugal. |
| AID556662 | Antimicrobial activity against multidrug resistant Enterobacter aerogenes isolate 17 by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Occurrence of efflux mechanism and cephalosporinase variant in a population of Enterobacter aerogenes and Klebsiella pneumoniae isolates producing extended-spectrum beta-lactamases. |
| AID563968 | Antibacterial activity against Escherichia coli TOP10 harboring beta-lactamase NDM-1 by Etest method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Characterization of a new metallo-beta-lactamase gene, bla(NDM-1), and a novel erythromycin esterase gene carried on a unique genetic structure in Klebsiella pneumoniae sequence type 14 from India. |
| AID325196 | Antibacterial activity against Haemophilus influenzae ATCC 49766 by standard serial agar dilution method | 2008 | Bioorganic & medicinal chemistry, Feb-15, Volume: 16, Issue:4 | A novel series of parenteral cephalosporins exhibiting potent activities against both Pseudomonas aeruginosa and other gram-negative pathogens. Part 2: Synthesis and structure-activity relationships. |
| AID574432 | Antimicrobial activity against Escherichia coli isolate 543 expressing beta-lactamase KPC2, CTX-M-15, TEM and PFGE cluster 4 isolated from synovial fluid of patient by vitek-2 method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Carbapenem-resistant KPC-2-producing Escherichia coli in a Tel Aviv Medical Center, 2005 to 2008. |
| AID544586 | Antimicrobial activity against Escherichia coli DH5[alpha] isolate GC 8128 expressing bla SHV-105 gene by microdilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Pyrosequencing using the single-nucleotide polymorphism protocol for rapid determination of TEM- and SHV-type extended-spectrum beta-lactamases in clinical isolates and identification of the novel beta-lactamase genes blaSHV-48, blaSHV-105, and blaTEM-155 |
| AID573368 | Antibacterial activity against ceftazidime-susceptible Proteus mirabilis assessed as susceptible isolates by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID499060 | Antimicrobial activity against Enterobacter aerogenes PU41T expressing CTX-M-14, DHA-1, qnrS1 by CLSI method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Phenotypic and genotypic characterization of Enterobacteriaceae with decreased susceptibility to carbapenems: results from large hospital-based surveillance studies in China. |
| AID373211 | Ratio of Kcat to Km for Bacillus clausii NR beta-lactamase BCL1 expressed in Escherichia coli BL21 (DE3) relative to benzyl-penicillin | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Molecular and biochemical characterization of the chromosome-encoded class A beta-lactamase BCL-1 from Bacillus clausii. |
| AID540947 | Antimicrobial activity against Escherichia coli DH5[alpha] harboring pB-c36 plasmid expressing cephalosporinase CMY-36 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | CMY-31 and CMY-36 cephalosporinases encoded by ColE1-like plasmids. |
| AID1225775 | Antibacterial activity against Enterobacter cloacae EC1010 expressing CMY-6 by broth microdilution method | 2015 | Journal of medicinal chemistry, May-14, Volume: 58, Issue:9 | Discovery of a Cyclic Boronic Acid β-Lactamase Inhibitor (RPX7009) with Utility vs Class A Serine Carbapenemases. |
| AID499070 | Antimicrobial activity against carbapenem-resistant Klebsiella pneumoniae GZ84 deficient in SHV-11, aac(6')-Ib-cr, ompK35 by CLSI method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Phenotypic and genotypic characterization of Enterobacteriaceae with decreased susceptibility to carbapenems: results from large hospital-based surveillance studies in China. |
| AID571936 | Antimicrobial activity against Escherichia coli MC4100 harboring weak promoter and active promoter P2 in beta-lactamase GES-1 by Etest | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Relative strengths of the class 1 integron promoter hybrid 2 and the combinations of strong and hybrid 1 with an active p2 promoter. |
| AID562777 | Antimicrobial activity against Escherichia coli DH10B by Etest | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | TEM-168, a heretofore laboratory-derived TEM beta-lactamase variant found in an Escherichia coli clinical isolate. |
| AID522576 | Antimicrobial activity against Escherichia coli isolate 7014517 AmpC with LAA insertion at position 295 | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Occurrence of ST23 complex phylogroup A Escherichia coli isolates producing extended-spectrum AmpC beta-lactamase in a French hospital. |
| AID555681 | Antimicrobial activity against Escherichia coli DH10B by disk diffusion method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Novel plasmid-encoded ceftazidime-hydrolyzing CTX-M-53 extended-spectrum beta-lactamase from Salmonella enterica serotypes Westhampton and Senftenberg. |
| AID373033 | Antimicrobial activity against imipenem and meropenem-resistant Acinetobacter baumannii isolate BJ3-23 by CLSI agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Molecular epidemiology of clinical isolates of carbapenem-resistant Acinetobacter spp. from Chinese hospitals. |
| AID564459 | Antimicrobial activity against Pseudomonas aeruginosa isolate 988 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | In vivo efficacy of 1- and 2-gram human simulated prolonged infusions of doripenem against Pseudomonas aeruginosa. |
| AID279182 | Antibacterial activity against Enterobacter cloacae S3 isolate by agar dilution technique | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2 | Novel Ambler class A beta-lactamase LAP-1 and its association with the plasmid-mediated quinolone resistance determinant QnrS1. |
| AID556353 | Antimicrobial activity against Salmonella enterica serotype concord expressing extended-spectrum beta-lactamase SHV-12 by disc diffusion method | 2009 | Antimicrobial agents and chemotherapy, 05, Volume: 53, Issue:5 | Chromosomal integration of the extended-spectrum beta-lactamase gene blaCTX-M-15 in Salmonella enterica serotype Concord isolates from internationally adopted children. |
| AID531755 | Antibacterial activity against Pseudomonas aeruginosa 2126 by twofold serial dilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Resistance and virulence of Pseudomonas aeruginosa clinical strains overproducing the MexCD-OprJ efflux pump. |
| AID565527 | Antibacterial activity against mexB, mexY and mexD expressing Pseudomonas aeruginosa isolate Paebeta-08 harboring A residue at 105 position in PDC- 2 and insertion of ISPa27 sequence in OprD gene by Etest method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Molecular epidemiology and mechanisms of carbapenem resistance in Pseudomonas aeruginosa. |
| AID567739 | Antimicrobial activity against Pseudomonas aeruginosa OC 11678 expressing 34 fold elevated AmpC expression by broth macrodilution method | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | Differential selection of single-step AmpC or efflux mutants of Pseudomonas aeruginosa by using cefepime, ceftazidime, or ceftobiprole. |
| AID535136 | Antimicrobial activity against Ceftazidime susceptible Pseudomonas aeruginosa assessed as resistant isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activity of doripenem, a carbapenem for the treatment of challenging infections caused by gram-negative bacteria, against recent clinical isolates from the United States. |
| AID564466 | Antimicrobial activity against Pseudomonas aeruginosa isolate 821 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | In vivo efficacy of 1- and 2-gram human simulated prolonged infusions of doripenem against Pseudomonas aeruginosa. |
| AID571937 | Antimicrobial activity against Escherichia coli MC4100 harboring strong promoter and active promoter P2 in beta-lactamase GES-1 by Etest | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Relative strengths of the class 1 integron promoter hybrid 2 and the combinations of strong and hybrid 1 with an active p2 promoter. |
| AID535758 | Antimicrobial activity against hospital-acquired Escherichia coli expressing extended spectrum beta-lactamase obtained from patient with intra-abdominal infection assessed as susceptible isolates by EUCAST method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Incidence and antimicrobial susceptibility of Escherichia coli and Klebsiella pneumoniae with extended-spectrum beta-lactamases in community- and hospital-associated intra-abdominal infections in Europe: results of the 2008 Study for Monitoring Antimicrob |
| AID554438 | Ratio of MIC for Pseudomonas aeruginosa 2804 to MIC for Pseudomonas aeruginosa PAO1 | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Efflux unbalance in Pseudomonas aeruginosa isolates from cystic fibrosis patients. |
| AID522392 | Ratio of Kcat Km for Aeromonas enteropelogenes Beta-lactamase TRU1 | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Genetic and biochemical characterization of TRU-1, the endogenous class C beta-lactamase from Aeromonas enteropelogenes. |
| AID1143120 | Antibacterial activity against Pseudomonas aeruginosa PAO1 assessed as inhibition of visible growth after 18 hrs incubation by standard broth dilution method | 2014 | Journal of medicinal chemistry, May-22, Volume: 57, Issue:10 | New Ianthelliformisamine derivatives as antibiotic enhancers against resistant Gram-negative bacteria. |
| AID582971 | Antimicrobial activity against ampD::lox gene-deficient Pseudomonas aeruginosa PAO1 by Etest method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | NagZ inactivation prevents and reverts beta-lactam resistance, driven by AmpD and PBP 4 mutations, in Pseudomonas aeruginosa. |
| AID516147 | Antibacterial activity against Pulsotype D Acinetobacter genomosp. 3 isolate 18 containing IMP-1, OXA-58, ADC-18, ISAba1, ISAba3, repAcil, IS1008, intI1 genetic elements by broth micro dilution | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Molecular characterization of beta-lactamase genes and their genetic structures in Acinetobacter genospecies 3 isolates in Taiwan. |
| AID372608 | Antibacterial activity against Escherichia coli DH5alpha producing beta-lactamase TEM-12 by microdilution method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | TEM-158 (CMT-9), a new member of the CMT-type extended-spectrum beta-lactamases. |
| AID495791 | Antimicrobial activity against Pseudomonas fluorescens isolate PF-1 expressing beta-lactamase BIC-1 by Etest | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Novel ambler class A carbapenem-hydrolyzing beta-lactamase from a Pseudomonas fluorescens isolate from the Seine River, Paris, France. |
| AID547517 | Antimicrobial activity against Streptococcus anginosus obtained from patient with cystic fibrosis assessed as non-susceptible isolates grown on brain heart infusion agar at 30 ug/ml after 24 hrs at 37 degC by disk diffusion method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Macrolide and clindamycin resistance in Streptococcus milleri group isolates from the airways of cystic fibrosis patients. |
| AID373038 | Antimicrobial activity against imipenem and meropenem-resistant Acinetobacter baumannii isolate NJ59 by CLSI agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Molecular epidemiology of clinical isolates of carbapenem-resistant Acinetobacter spp. from Chinese hospitals. |
| AID368724 | Ratio of Kcat to Km of Pseudomonas aeruginosa MK-1184 AmpC assessed as drug hydrolysis by spectrophotometry relative to cephaloridine | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID1559403 | Volume of distribution at steady state in mouse at 10 mg/kg, iv after 1 to 6 hrs by LC-MS/MS analysis | 2020 | Journal of medicinal chemistry, 03-26, Volume: 63, Issue:6 | Discovery of Taniborbactam (VNRX-5133): A Broad-Spectrum Serine- and Metallo-β-lactamase Inhibitor for Carbapenem-Resistant Bacterial Infections. |
| AID571890 | Antimicrobial activity against ISAba1 linked with the blaOXA-51-type beta-lactamase harboring Acinetobacter baumannii beta clonal group isolate 9 expressing ampC, ompA, adeB, adeM by Etest method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Correlation of antimicrobial resistance with beta-lactamases, the OmpA-like porin, and efflux pumps in clinical isolates of Acinetobacter baumannii endemic to New York City. |
| AID373045 | Antimicrobial activity against imipenem and meropenem-resistant Acinetobacter baumannii isolate ZS15 by CLSI agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Molecular epidemiology of clinical isolates of carbapenem-resistant Acinetobacter spp. from Chinese hospitals. |
| AID556691 | Antimicrobial activity against multidrug resistant Enterobacter aerogenes ATCC 15038 harboring pDrive plasmid by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Occurrence of efflux mechanism and cephalosporinase variant in a population of Enterobacter aerogenes and Klebsiella pneumoniae isolates producing extended-spectrum beta-lactamases. |
| AID529660 | Ratio of Kcat to Km for Pseudomonas aeruginosa COL-1 beta-lactamase VIM-2 | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | VIM-15 and VIM-16, two new VIM-2-like metallo-beta-lactamases in Pseudomonas aeruginosa isolates from Bulgaria and Germany. |
| AID554396 | Antimicrobial activity against Pseudomonas aeruginosa isolate 2721 obtained from cystic fibrosis patient by disk diffusion method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Efflux unbalance in Pseudomonas aeruginosa isolates from cystic fibrosis patients. |
| AID1373300 | Antimicrobial activity against Escherichia coli expressing beta-lactamase TEM-16 by CLSI broth microdilution method | 2018 | Bioorganic & medicinal chemistry letters, 02-15, Volume: 28, Issue:4 | Optimization of novel monobactams with activity against carbapenem-resistant Enterobacteriaceae - Identification of LYS228. |
| AID559270 | Antimicrobial activity against Proteus vulgaris Pv7 expressing beta-lactamase PER-1 by Etest | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Emergence of extended-spectrum beta-lactamase PER-1 in Proteus vulgaris and Providencia stuartii isolates from Algiers, Algeria. |
| AID285590 | Antimicrobial activity against Pseudomonas aeruginosa 65.38-1 tracheal isolates from mechanically ventilated tuberculosis patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID564456 | Antimicrobial activity against Pseudomonas aeruginosa isolate 22 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | In vivo efficacy of 1- and 2-gram human simulated prolonged infusions of doripenem against Pseudomonas aeruginosa. |
| AID285261 | Antimicrobial activity against recombinant Escherichia coli DH5-alpha isolate expressing pBK-TEM-36 and IRT by disk diffusion assay | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Evolution of TEM-type enzymes: biochemical and genetic characterization of two new complex mutant TEM enzymes, TEM-151 and TEM-152, from a single patient. |
| AID495512 | Antibacterial activity against multidrug-resistant Acinetobacter baumannii BM4666 by antimicrobial susceptibility assay | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Screening and quantification of the expression of antibiotic resistance genes in Acinetobacter baumannii with a microarray. |
| AID520385 | Activity at Pseudomonas aeruginosa M5109 metallo-beta-lactamase VIM-11 by spectrometry | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Biochemical characterization of metallo-beta-lactamase VIM-11 from a Pseudomonas aeruginosa clinical strain. |
| AID562769 | Antimicrobial activity against Escherichia coli DH10B transformant harboring blaTEM-168 gene by Etest in presence of clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | TEM-168, a heretofore laboratory-derived TEM beta-lactamase variant found in an Escherichia coli clinical isolate. |
| AID285270 | Activity of Escherichia coli BL21(DE3) beta-lactamase TEM36 | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Evolution of TEM-type enzymes: biochemical and genetic characterization of two new complex mutant TEM enzymes, TEM-151 and TEM-152, from a single patient. |
| AID535368 | Antimicrobial activity against Pseudomonas aeruginosa isolated from ICU patient by broth microdilution method in presence of Tazobactam | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activity of doripenem, a carbapenem for the treatment of challenging infections caused by gram-negative bacteria, against recent clinical isolates from the United States. |
| AID522001 | Antimicrobial activity against Escherichia coli isolate J53 harboring p5A containing beta-lactamase OXA-48 located within transposon Tn1999 by Etest method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Spread of OXA-48-encoding plasmid in Turkey and beyond. |
| AID1143118 | Antibacterial activity against Enterobacter aerogenes EA289 assessed as inhibition of visible growth after 18 hrs incubation by standard broth dilution method | 2014 | Journal of medicinal chemistry, May-22, Volume: 57, Issue:10 | New Ianthelliformisamine derivatives as antibiotic enhancers against resistant Gram-negative bacteria. |
| AID535168 | Antimicrobial activity against imipenem susceptible Acinetobacter assessed as susceptible isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activity of doripenem, a carbapenem for the treatment of challenging infections caused by gram-negative bacteria, against recent clinical isolates from the United States. |
| AID1079939 | Cirrhosis, proven histopathologically. Value is number of references indexed. [column 'CIRRH' in source] | |||
| AID533565 | Antimicrobial activity against Pseudomonas aeruginosa isolate PA399 expressing VIM-2 beta-lactamase | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | First survey of metallo-beta-lactamases in clinical isolates of Pseudomonas aeruginosa in a German university hospital. |
| AID252616 | Mean lysis diameter of porin deficient Enterobacter aerogenes EA289 by standard disk diffusion method on MH agar | 2005 | Journal of medicinal chemistry, Mar-10, Volume: 48, Issue:5 | Beta-lactam screening by specific residues of the OmpF eyelet. |
| AID544965 | Antimicrobial activity against Proteus mirabilis expressing extended-spectrum beta-lactamase by Etest based on single determinant | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Characterization and sequence analysis of extended-spectrum-{beta}-lactamase-encoding genes from Escherichia coli, Klebsiella pneumoniae, and Proteus mirabilis isolates collected during tigecycline phase 3 clinical trials. |
| AID546620 | Antimicrobial activity against Escherichia coli harboring beta-lactamase VIM-2 by Etest | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Carbapenem resistance among Pseudomonas aeruginosa strains from India: evidence for nationwide endemicity of multiple metallo-beta-lactamase clones (VIM-2, -5, -6, and -11 and the newly characterized VIM-18). |
| AID565713 | Antibacterial activity against oprD, mexB, mexY and mexD expressing Pseudomonas aeruginosa isolate Paebeta-18 harboring A residue at 105 position in PDC- 3 by Etest method in presence of cloxacillin | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Molecular epidemiology and mechanisms of carbapenem resistance in Pseudomonas aeruginosa. |
| AID562334 | Antimicrobial activity against Escherichia coli DH5alpha harboring plasmid pBC-SK after 18 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | IND-6, a highly divergent IND-type metallo-beta-lactamase from Chryseobacterium indologenes strain 597 isolated in Burkina Faso. |
| AID534300 | Antimicrobial activity against metallo-beta-lactamase-negative Pseudomonas aeruginosa isolate PA459 | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | First survey of metallo-beta-lactamases in clinical isolates of Pseudomonas aeruginosa in a German university hospital. |
| AID535697 | Antimicrobial activity against Azide-resistant Escherichia coli J53 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Detection of the pandemic O25-ST131 human virulent Escherichia coli CTX-M-15-producing clone harboring the qnrB2 and aac(6')-Ib-cr genes in a dog. |
| AID558807 | Antimicrobial activity against extended spectrum beta-lactamase-deficient Klebsiella pneumoniae assessed as percent susceptible isolates by CLSI method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Emergence of high levels of extended-spectrum-beta-lactamase-producing gram-negative bacilli in the Asia-Pacific region: data from the Study for Monitoring Antimicrobial Resistance Trends (SMART) program, 2007. |
| AID520811 | Antimicrobial activity against CTX-M-59 and TEM-1 producing Klebsiella pneumoniae transconjugants/transformants with PFGE pulsotype E by Etest | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Multiclonal outbreak of Klebsiella pneumoniae producing extended-spectrum beta-lactamase CTX-M-2 and novel variant CTX-M-59 in a neonatal intensive care unit in Brazil. |
| AID341107 | Antibacterial activity against Escherichia coli transconjugant carrying pEC28 isolate eby Etest | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8 | First occurrence of an Escherichia coli clinical isolate producing the VIM-1/VIM-2 hybrid metallo-beta-lactamase VIM-12. |
| AID1318932 | Antibacterial activity against multidrug-resistant/tobramycin-susceptible Pseudomonas aeruginosa isolate 108590 | 2016 | Journal of medicinal chemistry, 09-22, Volume: 59, Issue:18 | Hybrid Antibiotic Overcomes Resistance in P. aeruginosa by Enhancing Outer Membrane Penetration and Reducing Efflux. |
| AID567734 | Antimicrobial activity against Pseudomonas aeruginosa OC 12070 by broth macrodilution method | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | Differential selection of single-step AmpC or efflux mutants of Pseudomonas aeruginosa by using cefepime, ceftazidime, or ceftobiprole. |
| AID528969 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus isolated from ICU patient respiratory tract assessed as resistant isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Antimicrobial-resistant pathogens in intensive care units in Canada: results of the Canadian National Intensive Care Unit (CAN-ICU) study, 2005-2006. |
| AID429077 | Antibacterial activity against Escherichia coli J53 by E test method | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | Plasmid-mediated carbapenem-hydrolyzing beta-lactamase KPC-2 in Klebsiella pneumoniae isolate from Greece. |
| AID524924 | Antimicrobial activity against beta lactamase CTX-M-10 producing Escherichia coli MI1443 by E-test | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Mutational events in cefotaximase extended-spectrum beta-lactamases of the CTX-M-1 cluster involved in ceftazidime resistance. |
| AID368730 | Activity of Pseudomonas aeruginosa AmpC assessed as drug hydrolysis by spectrophotometry relative to cephaloridine | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID576283 | Antimicrobial activity against ESBL-positive Klebsiella pneumoniae 17829 by Etest | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | An ertapenem-resistant extended-spectrum-beta-lactamase-producing Klebsiella pneumoniae clone carries a novel OmpK36 porin variant. |
| AID519179 | Antimicrobial activity against MexXY-OprM-overproducing Pseudomonas aeruginosa PAO1 harboring MexY agrZ mutant and MexZ mutant gene selected after 4ug/ml of gentamycin exposure | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Relationship between antibiotic use and incidence of MexXY-OprM overproducers among clinical isolates of Pseudomonas aeruginosa. |
| AID285587 | Antimicrobial activity against Pseudomonas aeruginosa 65.36-2 tracheal isolates from mechanically ventilated tuberculosis patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID508296 | Inhibition of PBP2 in penicillin-resistant Enterococcus faecium D63r membranes assessed as inhibition of fluorescent ampicillin binding after 20 mins at 37 degC | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2 | Interaction of ceftobiprole with the low-affinity PBP 5 of Enterococcus faecium. |
| AID301084 | Antibacterial activity against Pseudomonas aeruginosa SR24 after 20 hrs by agar dilution method | 2007 | Bioorganic & medicinal chemistry, Nov-01, Volume: 15, Issue:21 | A novel series of parenteral cephalosporins exhibiting potent activities against Pseudomonas aeruginosa and other Gram-negative pathogens: synthesis and structure-activity relationships. |
| AID584555 | Antimicrobial activity against Acinetobacter lwoffii isolate B expressing beta-lactamase OXA-164 isolated from tracheal secretion of patient by vitek 2 system | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | In vivo selection of a missense mutation in adeR and conversion of the novel blaOXA-164 gene into blaOXA-58 in carbapenem-resistant Acinetobacter baumannii isolates from a hospitalized patient. |
| AID495657 | Antimicrobial activity against Escherichia coli TOP10 expressing recombinant beta-lactamase BEL-1 by solid agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | BEL-2, an extended-spectrum beta-lactamase with increased activity toward expanded-spectrum cephalosporins in Pseudomonas aeruginosa. |
| AID532391 | Antibacterial activity against VIM-1 producing Pseudomonas aeruginosa clone A1 isolate FG-17X-14 by Etest method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | First countrywide survey of acquired metallo-beta-lactamases in gram-negative pathogens in Italy. |
| AID565722 | Antibacterial activity against oprD, mexB, mexY and mexD expressing Pseudomonas aeruginosa isolate Paebeta-27 harboring A residue at 105 position in PDC- 7 by Etest method in presence of cloxacillin | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Molecular epidemiology and mechanisms of carbapenem resistance in Pseudomonas aeruginosa. |
| AID564455 | Antimicrobial activity against Pseudomonas aeruginosa isolate 1095 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | In vivo efficacy of 1- and 2-gram human simulated prolonged infusions of doripenem against Pseudomonas aeruginosa. |
| AID571695 | Antimicrobial activity against Acinetobacter baumannii alpha clonal group isolate 4 expressing ampC, ompA, adeB, adeM, aacC1, aadA1 by Etest method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Correlation of antimicrobial resistance with beta-lactamases, the OmpA-like porin, and efflux pumps in clinical isolates of Acinetobacter baumannii endemic to New York City. |
| AID1318930 | Antibacterial activity against multidrug-resistant/tobramycin-susceptible Pseudomonas aeruginosa isolate 86141 | 2016 | Journal of medicinal chemistry, 09-22, Volume: 59, Issue:18 | Hybrid Antibiotic Overcomes Resistance in P. aeruginosa by Enhancing Outer Membrane Penetration and Reducing Efflux. |
| AID556694 | Antimicrobial activity against multidrug resistant Escherichia coli DH5[alpha] by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Occurrence of efflux mechanism and cephalosporinase variant in a population of Enterobacter aerogenes and Klebsiella pneumoniae isolates producing extended-spectrum beta-lactamases. |
| AID529198 | Antibacterial activity against AmpC-producing Escherichia coli assessed as sensitive isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Comparison of antimicrobial resistance profiles among extended-spectrum-beta-lactamase-producing and acquired AmpC beta-lactamase-producing Escherichia coli isolates from Canadian intensive care units. |
| AID561446 | Antibacterial activity against Escherichia coli DH10B harboring plasmid BCSK carrying beta-lactamase CMY-2 gene by Etest method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Reduced susceptibility to cefepime among Escherichia coli clinical isolates producing novel variants of CMY-2 beta-lactamase. |
| AID368486 | Antibacterial activity against Serratia marcescens 4104 producing beta lactamase AmpC by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID518724 | Antimicrobial activity against Escherichia coli TOP10 harboring beta-lactamase DIM-1 by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Characterization of DIM-1, an integron-encoded metallo-beta-lactamase from a Pseudomonas stutzeri clinical isolate in the Netherlands. |
| AID518817 | Antibacterial activity against Acinetobacter genomosp. 3 isolates assessed as percent of resistance isolates by broth micro dilution | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Molecular characterization of beta-lactamase genes and their genetic structures in Acinetobacter genospecies 3 isolates in Taiwan. |
| AID495514 | Antibacterial activity against multidrug-resistant Acinetobacter baumannii BM4668 by antimicrobial susceptibility assay | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Screening and quantification of the expression of antibiotic resistance genes in Acinetobacter baumannii with a microarray. |
| AID535710 | Antibacterial activity against Escherichia coli TOP10 expressing AmpC-B2 S287N mutant protein by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Role of the Ser-287-Asn replacement in the hydrolysis spectrum extension of AmpC beta-lactamases in Escherichia coli. |
| AID565523 | Antibacterial activity against mexB, mexY and mexD expressing Pseudomonas aeruginosa isolate Paebeta-12 harboring A residue at 105 position in PDC- 2 and polymorphic OprD gene by Etest method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Molecular epidemiology and mechanisms of carbapenem resistance in Pseudomonas aeruginosa. |
| AID528840 | Antimicrobial activity against penicillin-resistant Streptococcus pneumoniae isolated from ICU patient respiratory tract assessed as resistant isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Antimicrobial-resistant pathogens in intensive care units in Canada: results of the Canadian National Intensive Care Unit (CAN-ICU) study, 2005-2006. |
| AID556673 | Antimicrobial activity against multidrug resistant Klebsiella pneumoniae ATCC 11296 by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Occurrence of efflux mechanism and cephalosporinase variant in a population of Enterobacter aerogenes and Klebsiella pneumoniae isolates producing extended-spectrum beta-lactamases. |
| AID554442 | Ratio of MIC for Pseudomonas aeruginosa 3066 to MIC for Pseudomonas aeruginosa PAO1 | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Efflux unbalance in Pseudomonas aeruginosa isolates from cystic fibrosis patients. |
| AID534297 | Antimicrobial activity against Pseudomonas aeruginosa isolate PA481 expressing VIM-2 beta-lactamase | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | First survey of metallo-beta-lactamases in clinical isolates of Pseudomonas aeruginosa in a German university hospital. |
| AID499052 | Antimicrobial activity against Escherichia coli PU60T expressing CMY-2 by CLSI method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Phenotypic and genotypic characterization of Enterobacteriaceae with decreased susceptibility to carbapenems: results from large hospital-based surveillance studies in China. |
| AID508741 | Antibacterial activity against Pseudomonas aeruginosa assessed as percent nonsusceptible isolates by broth microdilution assay | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2 | Activity of a new antipseudomonal cephalosporin, CXA-101 (FR264205), against carbapenem-resistant and multidrug-resistant Pseudomonas aeruginosa clinical strains. |
| AID405817 | Antimicrobial activity against Pseudomonas putida 12346 isolate harboring bla IMP-1 carrying integron In86 containing aminoglycoside resistance gene aac(6')-3 | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | Characterization of an integron carrying blaIMP-1 and a new aminoglycoside resistance gene, aac(6')-31, and its dissemination among genetically unrelated clinical isolates in a Brazilian hospital. |
| AID498840 | Antimicrobial activity against Klebsiella pneumoniae GZ66T expressing SHV-11, DHA-1 by CLSI method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Phenotypic and genotypic characterization of Enterobacteriaceae with decreased susceptibility to carbapenems: results from large hospital-based surveillance studies in China. |
| AID546180 | Antimicrobial activity against AmpC overproducing Pseudomonas aeruginosa isolate Pae-beta-20 with PDC-4 variant by Etest | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Extended-spectrum cephalosporinases in Pseudomonas aeruginosa. |
| AID368538 | Ratio of Kcat to Km of Providencia stuartii AmpC assessed as drug hydrolysis by spectrophotometry relative to cephaloridine | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID511666 | Antimicrobial activity against beta-lactam resistant beta-lactam resistant Pseudomonas aeruginosa PAOD3 harboring oprD spontaneous mutant and deficient in ampD gene selected in vitro after antipseudomonal treatment of intensive care unit patient by broth | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Activity of a new cephalosporin, CXA-101 (FR264205), against beta-lactam-resistant Pseudomonas aeruginosa mutants selected in vitro and after antipseudomonal treatment of intensive care unit patients. |
| AID555557 | Antimicrobial activity against Pseudomonas aeruginosa isolate 27135 expressing VIM-2 beta lactamase gene by Etest | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | First organisms with acquired metallo-beta-lactamases (IMP-13, IMP-22, and VIM-2) reported in Austria. |
| AID524003 | Antimicrobial activity against Acinetobacter baumannii ATCC 15151 harboring ISAba1-blaOXA-66 gene by Etest | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Genetic basis of multidrug resistance in Acinetobacter clinical isolates in Taiwan. |
| AID394494 | Antimicrobial activity against Escherichia coli MC4100 harboring pACYC184 plasmid by agar dilution technique | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10 | Plasmid-encoded ACC-4, an extended-spectrum cephalosporinase variant from Escherichia coli. |
| AID563971 | Antibacterial activity against Escherichia coli NF-NDM-1 by Etest method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Characterization of a new metallo-beta-lactamase gene, bla(NDM-1), and a novel erythromycin esterase gene carried on a unique genetic structure in Klebsiella pneumoniae sequence type 14 from India. |
| AID285443 | Ratio of kcat to Km of Citrobacter gillenii CIP 106783 Beta-lactamase GIL1 expressed in Escherichia coli DH10B relative to benzyl-penicillin | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Chromosome-encoded narrow-spectrum Ambler class A beta-lactamase GIL-1 from Citrobacter gillenii. |
| AID516142 | Antibacterial activity against Pulsotype L Acinetobacter genomosp. 3 isolate 7 containing IMP-1, OXA-58, ADC-18, ISAba1, ISAba3, IS1008, intI1 genetic elements by broth micro dilution | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Molecular characterization of beta-lactamase genes and their genetic structures in Acinetobacter genospecies 3 isolates in Taiwan. |
| AID511669 | Antimicrobial activity against beta-lactam resistant Pseudomonas aeruginosa PAOD3 harboring oprD spontaneous mutant and deficient in dacB gene selected in vitro after antipseudomonal treatment of intensive care unit patient by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Activity of a new cephalosporin, CXA-101 (FR264205), against beta-lactam-resistant Pseudomonas aeruginosa mutants selected in vitro and after antipseudomonal treatment of intensive care unit patients. |
| AID368308 | Ratio of Kcat to Km of Escherichia coli TEM1 assessed as drug hydrolysis by spectrophotometry | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID521284 | Antimicrobial activity against CTX-M-2 and TEM-1 producing Klebsiella pneumoniae transconjugants/transformants with PFGE pulsotype H by Etest | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Multiclonal outbreak of Klebsiella pneumoniae producing extended-spectrum beta-lactamase CTX-M-2 and novel variant CTX-M-59 in a neonatal intensive care unit in Brazil. |
| AID535651 | Antimicrobial activity against aac(6')-Ib-cr-positive Escherichia coli FJ3T harboring wild-type GyrA, ParC, GyrB and qnrB genes by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | High prevalence of plasmid-mediated quinolone resistance genes qnr and aac(6')-Ib-cr in clinical isolates of Enterobacteriaceae from nine teaching hospitals in China. |
| AID373755 | Antibacterial activity against imipenem-susceptible Acinetobacter baumannii ab12 by broth dilution method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | An OXA-66/OXA-51-like carbapenemase and possibly an efflux pump are associated with resistance to imipenem in Acinetobacter baumannii. |
| AID528833 | Antimicrobial activity against CTX-M ESBL producing Escherichia coli isolated from ICU patient blood assessed as resistant isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Antimicrobial-resistant pathogens in intensive care units in Canada: results of the Canadian National Intensive Care Unit (CAN-ICU) study, 2005-2006. |
| AID573399 | Antimicrobial activity against mucA::lox, mutS::lox-deficient Pseudomonas aeruginosa PAOMSAA biofilm harboring nfxB T86C mutant gene selected at 4 ug/ml of azithromycin after 2 passages by Etest method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Azithromycin in Pseudomonas aeruginosa biofilms: bactericidal activity and selection of nfxB mutants. |
| AID368523 | Activity of Enterobacter cloacae 4080 AmpC (P99) assessed as drug hydrolysis by spectrophotometry | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID325190 | Antibacterial activity against Enterobacter cloacae ATCC 13047 by standard serial agar dilution method | 2008 | Bioorganic & medicinal chemistry, Feb-15, Volume: 16, Issue:4 | A novel series of parenteral cephalosporins exhibiting potent activities against both Pseudomonas aeruginosa and other gram-negative pathogens. Part 2: Synthesis and structure-activity relationships. |
| AID528828 | Antimicrobial activity against ESBL producing Klebsiella pneumoniae isolated from ICU patient blood assessed as resistant isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Antimicrobial-resistant pathogens in intensive care units in Canada: results of the Canadian National Intensive Care Unit (CAN-ICU) study, 2005-2006. |
| AID368315 | Antibacterial activity against Klebsiella pneumoniae 4094 producing beta lactamase TEM26 by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID565715 | Antibacterial activity against oprD, mexB, mexY and mexD expressing Pseudomonas aeruginosa isolate Paebeta-20 harboring A residue at 105 position in PDC- 4 by Etest method in presence of cloxacillin | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Molecular epidemiology and mechanisms of carbapenem resistance in Pseudomonas aeruginosa. |
| AID1139543 | Antibacterial activity against Escherichia coli DH5alpha expressing beta-lactamase VIM-2 by CLSI broth microdilution method | 2014 | Journal of medicinal chemistry, May-08, Volume: 57, Issue:9 | Siderophore receptor-mediated uptake of lactivicin analogues in gram-negative bacteria. |
| AID285262 | Antimicrobial activity against recombinant Escherichia coli DH5-alpha isolate expressing pBK-TEM-1 and TEM1 by disk diffusion assay | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Evolution of TEM-type enzymes: biochemical and genetic characterization of two new complex mutant TEM enzymes, TEM-151 and TEM-152, from a single patient. |
| AID534868 | Antimicrobial activity against ESBL producing Proteus mirabilis assessed as intermediate isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activity of doripenem, a carbapenem for the treatment of challenging infections caused by gram-negative bacteria, against recent clinical isolates from the United States. |
| AID368532 | Activity of Morganella morganii AmpC assessed as drug hydrolysis by spectrophotometry relative to cephaloridine | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID529664 | Ratio of Kcat to Km for Pseudomonas aeruginosa 166301 beta-lactamase VIM-16 relative to cephaloridine | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | VIM-15 and VIM-16, two new VIM-2-like metallo-beta-lactamases in Pseudomonas aeruginosa isolates from Bulgaria and Germany. |
| AID587525 | Antimicrobial activity against carbapenemases KPC-producing Klebsiella pneumoniae VA-361 infected in sc dosed CD-1 mouse in presence of 4 ug/ml Tazobactam beta-lactamase inhibitor | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1 | Evaluation of ceftazidime and NXL104 in two murine models of infection due to KPC-producing Klebsiella pneumoniae. |
| AID283534 | Antibacterial activity against Pseudomonas aeruginosa FE57 containing inactivated rplY gene with pARAL25 by microdilution method | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3 | Cumulative effects of several nonenzymatic mechanisms on the resistance of Pseudomonas aeruginosa to aminoglycosides. |
| AID524567 | Antimicrobial activity against Shigella isolate DH-20369 by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Identification and characterization of CTX-M-producing Shigella isolates in the United States. |
| AID1373296 | Antimicrobial activity against Escherichia coli expressing beta-lactamase VEB-4 by CLSI broth microdilution method | 2018 | Bioorganic & medicinal chemistry letters, 02-15, Volume: 28, Issue:4 | Optimization of novel monobactams with activity against carbapenem-resistant Enterobacteriaceae - Identification of LYS228. |
| AID394692 | Antibacterial activity against beta-lactams resistant Pseudomonas aeruginosa isolate expressing AmpC, MexAB-OprM pump by macrodilution technique | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10 | Pseudomonas aeruginosa may accumulate drug resistance mechanisms without losing its ability to cause bloodstream infections. |
| AID533569 | Antimicrobial activity against Pseudomonas aeruginosa isolate PA475 expressing VIM-2 beta-lactamase | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | First survey of metallo-beta-lactamases in clinical isolates of Pseudomonas aeruginosa in a German university hospital. |
| AID529195 | Antibacterial activity against ESBL-producing Escherichia coli assessed as sensitive isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Comparison of antimicrobial resistance profiles among extended-spectrum-beta-lactamase-producing and acquired AmpC beta-lactamase-producing Escherichia coli isolates from Canadian intensive care units. |
| AID559265 | Antimicrobial activity against rifampin-resistant Escherichia coli J53 transconjugated with Proteus vulgaris Pv7 expressing beta-lactamase PER-1 by disk diffusion method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Emergence of extended-spectrum beta-lactamase PER-1 in Proteus vulgaris and Providencia stuartii isolates from Algiers, Algeria. |
| AID561661 | Antimicrobial activity against Pseudomonas aeruginosa isolate OC17349 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Effect of MexXY overexpression on ceftobiprole susceptibility in Pseudomonas aeruginosa. |
| AID562338 | Ratio of Kcat to Km for Chryseobacterium indologenes 597 metallo-beta-lactamase IND-6 expressed in Escherichia coli DH5alpha by Michaelis-Menten equation | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | IND-6, a highly divergent IND-type metallo-beta-lactamase from Chryseobacterium indologenes strain 597 isolated in Burkina Faso. |
| AID532413 | Antibacterial activity against IMP-13 producing Pseudomonas aeruginosa clone C1 isolate AV-13X-28 by Etest method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | First countrywide survey of acquired metallo-beta-lactamases in gram-negative pathogens in Italy. |
| AID530327 | Antimicrobial activity against Escherichia coli XL1-Blue harboring pUCP carrying VIM-13 gene by Etest method | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Characterization of the new metallo-beta-lactamase VIM-13 and its integron-borne gene from a Pseudomonas aeruginosa clinical isolate in Spain. |
| AID567283 | Ratio of Kcat to Km for Acinetobacter baumannii ADC-33 beta-lactamase to Kcat to Km for Acinetobacter baumannii ADC-11 beta-lactamase | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | Extended-spectrum cephalosporinase in Acinetobacter baumannii. |
| AID322319 | Antibacterial activity against Escherichia coli DH5 alpha isolates by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Spread of extended-spectrum beta-lactamase CTX-M-producing escherichia coli clinical isolates in community and nosocomial environments in Portugal. |
| AID326265 | Antibacterial activity against Escherichia coli 3521r carrying pR352 encoding SCO1 by agar dilution technique | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | SCO-1, a novel plasmid-mediated class A beta-lactamase with carbenicillinase characteristics from Escherichia coli. |
| AID528533 | Antimicrobial activity against penicillin-resistant Streptococcus agalactiae B502 by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | First molecular characterization of group B streptococci with reduced penicillin susceptibility. |
| AID533000 | Antibacterial activity against IMP-18 producing Pseudomonas aeruginosa isolate P85 exhibiting PFGE K pattern by 2-fold agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | Nationwide investigation of extended-spectrum beta-lactamases, metallo-beta-lactamases, and extended-spectrum oxacillinases produced by ceftazidime-resistant Pseudomonas aeruginosa strains in France. |
| AID571036 | Antimicrobial activity against Pseudomonas aeruginosa isolate PA367 obtained from patient with cystic fibrosis by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Role of ampD homologs in overproduction of AmpC in clinical isolates of Pseudomonas aeruginosa. |
| AID369640 | Antibacterial activity against Acinetobacter baumannii A clone expressing carbapenemase-encoding blaOXA-40 gene by Etest method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Molecular epidemiology of imipenem-resistant Acinetobacter haemolyticus and Acinetobacter baumannii isolates carrying plasmid-mediated OXA-40 from a Portuguese hospital. |
| AID520974 | Antibacterial activity against Escherichia coli harboring pBC2303 expressing blaKPC gene plasmid by Etest method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Genetic structures at the origin of acquisition of the beta-lactamase bla KPC gene. |
| AID565541 | Antibacterial activity against oprD, mexB, mexY and mexD expressing Pseudomonas aeruginosa isolate Paebeta-05 harboring A residue at 105 position in PDC- 2 by Etest method in presence of cloxacillin | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Molecular epidemiology and mechanisms of carbapenem resistance in Pseudomonas aeruginosa. |
| AID547516 | Antimicrobial activity against Streptococcus anginosus obtained from patient with cystic fibrosis assessed as non-susceptible isolates grown on mueller-Hinton blood agar at 30 ug/ml after 24 hrs at 37 degC by disk diffusion method in presence of 5% defrib | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Macrolide and clindamycin resistance in Streptococcus milleri group isolates from the airways of cystic fibrosis patients. |
| AID368537 | Ratio of Kcat to Km of Providencia stuartii AmpC assessed as drug hydrolysis by spectrophotometry | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID565548 | Antibacterial activity against mexB, mexY and mexD expressing Pseudomonas aeruginosa isolate Paebeta-12 harboring A residue at 105 position in PDC- 2 and polymorphic OprD gene by Etest method in presence of cloxacillin | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Molecular epidemiology and mechanisms of carbapenem resistance in Pseudomonas aeruginosa. |
| AID524434 | Antimicrobial activity against Shigella flexneri isolate AM13291 by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Identification and characterization of CTX-M-producing Shigella isolates in the United States. |
| AID499127 | Antimicrobial activity against Pseudomonas aeruginosa OC 4351 infected in immunocompromized SKH1 mouse assessed as log change in bacterial colony forming unit at 25 mg/kg/day, sc | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vivo activity of ceftobiprole in murine skin infections due to Staphylococcus aureus and Pseudomonas aeruginosa. |
| AID565773 | Antimicrobial activity against Pseudomonas aeruginosa OC 12070 expressing 65 fold elevated mexX expression and 106 fold elevated mexY expression by broth macrodilution method | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | Differential selection of single-step AmpC or efflux mutants of Pseudomonas aeruginosa by using cefepime, ceftazidime, or ceftobiprole. |
| AID546619 | Antimicrobial activity against Escherichia coli harboring beta-lactamase VIM-18 by Etest | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Carbapenem resistance among Pseudomonas aeruginosa strains from India: evidence for nationwide endemicity of multiple metallo-beta-lactamase clones (VIM-2, -5, -6, and -11 and the newly characterized VIM-18). |
| AID279812 | Antimicrobial activity against carbapenem-resistant Klebsiella pneumoniae ZR01 from patient sputum by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2 | Plasmid-mediated KPC-2 in a Klebsiella pneumoniae isolate from China. |
| AID576296 | Antimicrobial activity against ESBL-positive Klebsiella pneumoniae 16830 harboring porin OmpK36 gene by Etest | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | An ertapenem-resistant extended-spectrum-beta-lactamase-producing Klebsiella pneumoniae clone carries a novel OmpK36 porin variant. |
| AID576267 | Antimicrobial activity against ESBL-positive Klebsiella pneumoniae 18918 harboring porin OmpK36V mutant gene by Etest | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | An ertapenem-resistant extended-spectrum-beta-lactamase-producing Klebsiella pneumoniae clone carries a novel OmpK36 porin variant. |
| AID520808 | Antimicrobial activity against CTX-M-2 and TEM-1 producing Klebsiella pneumoniae transconjugants/transformants with PFGE pulsotype B by Etest | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Multiclonal outbreak of Klebsiella pneumoniae producing extended-spectrum beta-lactamase CTX-M-2 and novel variant CTX-M-59 in a neonatal intensive care unit in Brazil. |
| AID522566 | Antimicrobial activity against Escherichia coli isolate 7008153 with AmpC beta-lactamase H296P mutation | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Occurrence of ST23 complex phylogroup A Escherichia coli isolates producing extended-spectrum AmpC beta-lactamase in a French hospital. |
| AID555661 | Antimicrobial activity against Salmonella enterica serotype Westhampton isolate 04CEB8273SAL expressing CTX-M-53 gene by disk diffusion method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Novel plasmid-encoded ceftazidime-hydrolyzing CTX-M-53 extended-spectrum beta-lactamase from Salmonella enterica serotypes Westhampton and Senftenberg. |
| AID528524 | Antimicrobial activity against penicillin-resistant Streptococcus agalactiae B1 by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | First molecular characterization of group B streptococci with reduced penicillin susceptibility. |
| AID561627 | Antimicrobial activity against Stenotrophomonas maltophilia KJ by twofold serial agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | AmpDI is involved in expression of the chromosomal L1 and L2 beta-lactamases of Stenotrophomonas maltophilia. |
| AID559262 | Antimicrobial activity against Proteus vulgaris Pv9 expressing beta-lactamase PER-1 by disk diffusion method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Emergence of extended-spectrum beta-lactamase PER-1 in Proteus vulgaris and Providencia stuartii isolates from Algiers, Algeria. |
| AID524937 | Antimicrobial activity against Escherichia coli MI1443 harboring V27A, Q38R, N106S and D240G mutations in beta lactamase CTX-M-3 by E-test | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Mutational events in cefotaximase extended-spectrum beta-lactamases of the CTX-M-1 cluster involved in ceftazidime resistance. |
| AID535721 | Ratio of Kcat to Km for Escherichia coli TOP10 beta-lactamase AmpC-A | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Role of the Ser-287-Asn replacement in the hydrolysis spectrum extension of AmpC beta-lactamases in Escherichia coli. |
| AID498884 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus OC 8525 assessed as inhibition of growth by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vivo activity of ceftobiprole in murine skin infections due to Staphylococcus aureus and Pseudomonas aeruginosa. |
| AID567738 | Antimicrobial activity against Pseudomonas aeruginosa OC 11678 expressing 33 fold elevated AmpC expression by broth macrodilution method | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | Differential selection of single-step AmpC or efflux mutants of Pseudomonas aeruginosa by using cefepime, ceftazidime, or ceftobiprole. |
| AID495515 | Antibacterial activity against Acinetobacter baumannii CIP70-10 by antimicrobial susceptibility assay | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Screening and quantification of the expression of antibiotic resistance genes in Acinetobacter baumannii with a microarray. |
| AID295849 | Antimicrobial activity against Streptococcus pyogenes KUKEM676 by disk diffusion method at 300 ug/disc | 2007 | European journal of medicinal chemistry, Jul, Volume: 42, Issue:7 | Synthesis of some novel heterocyclic compounds derived from diflunisal hydrazide as potential anti-infective and anti-inflammatory agents. |
| AID561445 | Antibacterial activity against Escherichia coli DH10B harboring plasmid BCSK carrying beta-lactamase CMY-44 gene by Etest method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Reduced susceptibility to cefepime among Escherichia coli clinical isolates producing novel variants of CMY-2 beta-lactamase. |
| AID522000 | Antimicrobial activity against Escherichia coli isolate J53 harboring p4A containing beta-lactamase OXA-48 located within transposon Tn1999 by Etest method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Spread of OXA-48-encoding plasmid in Turkey and beyond. |
| AID567746 | Antimicrobial activity against Pseudomonas aeruginosa OC 11678 expressing 15 fold elevated AmpC expression by broth macrodilution method | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | Differential selection of single-step AmpC or efflux mutants of Pseudomonas aeruginosa by using cefepime, ceftazidime, or ceftobiprole. |
| AID533761 | Antibacterial activity against OXA-28 producing Pseudomonas aeruginosa isolate P174 exhibiting PFGE E pattern by 2-fold agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | Nationwide investigation of extended-spectrum beta-lactamases, metallo-beta-lactamases, and extended-spectrum oxacillinases produced by ceftazidime-resistant Pseudomonas aeruginosa strains in France. |
| AID508724 | Antibacterial activity against carbapenem-resistant Pseudomonas aeruginosa isolate 1E2 PpA1 harboring acquired beta-lactamase OXA-144 by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2 | Activity of a new antipseudomonal cephalosporin, CXA-101 (FR264205), against carbapenem-resistant and multidrug-resistant Pseudomonas aeruginosa clinical strains. |
| AID571908 | Antimicrobial activity against ISAba1 linked with the blaOXA-51-type beta-lactamase harboring Acinetobacter baumannii beta clonal group isolate 18 expressing ompA, adeB, adeM, aacA4, blaSHV-5 by Etest method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Correlation of antimicrobial resistance with beta-lactamases, the OmpA-like porin, and efflux pumps in clinical isolates of Acinetobacter baumannii endemic to New York City. |
| AID544583 | Antimicrobial activity against Escherichia coli DH5[alpha] by microdilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Pyrosequencing using the single-nucleotide polymorphism protocol for rapid determination of TEM- and SHV-type extended-spectrum beta-lactamases in clinical isolates and identification of the novel beta-lactamase genes blaSHV-48, blaSHV-105, and blaTEM-155 |
| AID561673 | Antimicrobial activity against Pseudomonas aeruginosa isolate OC14812 harboring plasmid JAK16 expressing mexXY gene by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Effect of MexXY overexpression on ceftobiprole susceptibility in Pseudomonas aeruginosa. |
| AID573374 | Antibacterial activity against multidrug-resistant Acinetobacter assessed as susceptible isolates by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID519641 | Antimicrobial activity against Escherichia coli EPI300 harboring pCC1 carrying beta-lactamase CTX-M-3 gene by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Convergent in vivo and in vitro selection of ceftazidime resistance mutations at position 167 of CTX-M-3 beta-lactamase in hypermutable Escherichia coli strains. |
| AID555214 | Antibacterial activity against Acinetobacter genomosp. 3 isolate 243 by Etest method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Genetic variability among ampC genes from acinetobacter genomic species 3. |
| AID555210 | Antibacterial activity against Acinetobacter genomosp. 3 isolate 103 by Etest method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Genetic variability among ampC genes from acinetobacter genomic species 3. |
| AID528535 | Antimicrobial activity against penicillin-resistant Streptococcus agalactiae B513 by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | First molecular characterization of group B streptococci with reduced penicillin susceptibility. |
| AID554391 | Antimicrobial activity against Pseudomonas aeruginosa isolate 615R obtained from cystic fibrosis patient by disk diffusion method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Efflux unbalance in Pseudomonas aeruginosa isolates from cystic fibrosis patients. |
| AID625282 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for cirrhosis | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID368545 | Ratio of Kcat to Km of Pseudomonas aeruginosa 18SH AmpC assessed as drug hydrolysis by spectrophotometry | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID562778 | Antimicrobial activity against Escherichia coli DH10B by Etest in presence of clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | TEM-168, a heretofore laboratory-derived TEM beta-lactamase variant found in an Escherichia coli clinical isolate. |
| AID285609 | Antimicrobial activity against Pseudomonas aeruginosa 65.68-1 tracheal isolates from mechanically ventilated tuberculosis patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID562739 | Antimicrobial activity against Escherichia coli DH5[alpha] harboring pBC-CTX-M-71 plasmid by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | New variant of CTX-M-type extended-spectrum beta-lactamases, CTX-M-71, with a Gly238Cys substitution in a Klebsiella pneumoniae isolate from Bulgaria. |
| AID509867 | Antibacterial activity against Acinetobacter baumannii isolate 2824 isolated from human urine | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Acinetobacter baumannii increases tolerance to antibiotics in response to monovalent cations. |
| AID521344 | Antimicrobial activity against Streptococcus pneumoniae ATCC BAA-343 | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Highly variable penicillin resistance determinants PBP 2x, PBP 2b, and PBP 1a in isolates of two Streptococcus pneumoniae clonal groups, Poland 23F-16 and Poland 6B-20. |
| AID584835 | Antimicrobial activity against Aeromonas allosaccharophila AL-1 expressing beta-lactamase PER6 by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | PER-6, an extended-spectrum beta-lactamase from Aeromonas allosaccharophila. |
| AID573354 | Antibacterial activity against ceftazidime-susceptible Escherichia coli assessed as resistant isolates by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID544494 | Antibacterial activity against Escherichia coli TOP10 harboring beta-lactamase KPC-5 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Phenotypic and enzymatic comparative analysis of the novel KPC variant KPC-5 and its evolutionary variants, KPC-2 and KPC-4. |
| AID394698 | Antibacterial activity against beta-lactams resistant Pseudomonas aeruginosa isolate expressing MexXY-OprM pump, TEM-2 by macrodilution technique | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10 | Pseudomonas aeruginosa may accumulate drug resistance mechanisms without losing its ability to cause bloodstream infections. |
| AID1373301 | Antimicrobial activity against Escherichia coli expressing beta-lactamase TEM-24 by CLSI broth microdilution method | 2018 | Bioorganic & medicinal chemistry letters, 02-15, Volume: 28, Issue:4 | Optimization of novel monobactams with activity against carbapenem-resistant Enterobacteriaceae - Identification of LYS228. |
| AID540215 | Volume of distribution at steady state in rat after iv administration | 2005 | Journal of pharmaceutical sciences, Jul, Volume: 94, Issue:7 | Extrapolation of human pharmacokinetic parameters from rat, dog, and monkey data: Molecular properties associated with extrapolative success or failure. |
| AID405824 | Antimicrobial activity against Acinetobacter baumannii 696 isolate harboring bla IMP-1 carrying integron In86 containing aminoglycoside resistance gene aac(6')-3 | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | Characterization of an integron carrying blaIMP-1 and a new aminoglycoside resistance gene, aac(6')-31, and its dissemination among genetically unrelated clinical isolates in a Brazilian hospital. |
| AID495911 | Antimicrobial activity in Escherichia coli J53 strain | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | VIM-19, a metallo-beta-lactamase with increased carbapenemase activity from Escherichia coli and Klebsiella pneumoniae. |
| AID521347 | Antimicrobial activity against Streptococcus pneumoniae isolate k-598 obtained from bronchoalveolar lavage fluid of patient | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Highly variable penicillin resistance determinants PBP 2x, PBP 2b, and PBP 1a in isolates of two Streptococcus pneumoniae clonal groups, Poland 23F-16 and Poland 6B-20. |
| AID565338 | Antibacterial activity against oprD, mexB, mexY and mexD expressing Pseudomonas aeruginosa isolate Paebeta-23 harboring A residue at 105 position in PDC- 5 by Etest method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Molecular epidemiology and mechanisms of carbapenem resistance in Pseudomonas aeruginosa. |
| AID572124 | Antimicrobial activity against ISAba1 linked with the blaOXA-51-type beta-lactamase harboring Acinetobacter baumannii lambda clonal group isolate 29 expressing ampC, ompA, adeM, aadB, aadA1 by Etest method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Correlation of antimicrobial resistance with beta-lactamases, the OmpA-like porin, and efflux pumps in clinical isolates of Acinetobacter baumannii endemic to New York City. |
| AID279187 | Ratio of kcat to Km of Enterobacter cloacae S3 isolate beta lactamase LAP1 expressed in Escherichia coli DH10B | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2 | Novel Ambler class A beta-lactamase LAP-1 and its association with the plasmid-mediated quinolone resistance determinant QnrS1. |
| AID573198 | Antimicrobial activity against mucA::lox-deficient Pseudomonas aeruginosa PAOMAA biofilm harboring nfxB C25T mutant gene selected at 1 ug/ml of azithromycin after 2 passages by Etest method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Azithromycin in Pseudomonas aeruginosa biofilms: bactericidal activity and selection of nfxB mutants. |
| AID498809 | Antimicrobial activity against Klebsiella pneumoniae ZJ99T expressing KPC-2, CTX-M-3, qnrS1 by CLSI method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Phenotypic and genotypic characterization of Enterobacteriaceae with decreased susceptibility to carbapenems: results from large hospital-based surveillance studies in China. |
| AID534087 | Antibacterial activity against levofloxacin-resistant Streptococcus pneumoniae assessed as percent susceptible isolates by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | In vitro activity of ceftaroline against Streptococcus pneumoniae isolates exhibiting resistance to penicillin, amoxicillin, and cefotaxime. |
| AID564527 | Antimicrobial activity against Escherichia coli TOP10 harboring pADC-33 plasmid by Etest method | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | Extended-spectrum cephalosporinase in Acinetobacter baumannii. |
| AID572144 | Antimicrobial activity against Acinetobacter baumannii unique clonal group isolate 39 expressing ampC, ompA, adeM by Etest method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Correlation of antimicrobial resistance with beta-lactamases, the OmpA-like porin, and efflux pumps in clinical isolates of Acinetobacter baumannii endemic to New York City. |
| AID532406 | Antibacterial activity against VIM-2 producing Pseudomonas aeruginosa clone B1 isolate SS-09X-45 by Etest method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | First countrywide survey of acquired metallo-beta-lactamases in gram-negative pathogens in Italy. |
| AID373204 | Antimicrobial activity against Bacillus clausii SIN by agar-dilution technique | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Molecular and biochemical characterization of the chromosome-encoded class A beta-lactamase BCL-1 from Bacillus clausii. |
| AID498806 | Antimicrobial activity against carbapenem-resistant Klebsiella pneumoniae ZJ71 deficient in KPC-2, TEM-1, SHV-11, CTX-M-14, ompK35 by CLSI method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Phenotypic and genotypic characterization of Enterobacteriaceae with decreased susceptibility to carbapenems: results from large hospital-based surveillance studies in China. |
| AID573378 | Antibacterial activity against imipenem-susceptible Acinetobacter assessed as resistant isolates by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID554434 | Ratio of MIC for Pseudomonas aeruginosa 2715 to MIC for Pseudomonas aeruginosa PAO1 | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Efflux unbalance in Pseudomonas aeruginosa isolates from cystic fibrosis patients. |
| AID520877 | Antibacterial activity against Achromobacter xylosoxidans MER by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Characterization of a naturally occurring class D beta-lactamase from Achromobacter xylosoxidans. |
| AID586086 | Antimicrobial activity against verocytotoxin-producing Escherichia coli isolate O157 obtained from animals and food assessed as percentage of resistant isolates by disk diffusion method | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Antimicrobial resistance testing of verocytotoxin-producing Escherichia coli and first description of TEM-52 extended-spectrum β-lactamase in serogroup O26. |
| AID567735 | Antimicrobial activity against Pseudomonas aeruginosa OC 11678 by broth macrodilution method | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | Differential selection of single-step AmpC or efflux mutants of Pseudomonas aeruginosa by using cefepime, ceftazidime, or ceftobiprole. |
| AID1361170 | Antimicrobial activity against Pseudomonas aeruginosa 27060deltaR1 harboring deletion of R1 plasmid in presence of human apo-transferrin by broth microdilution method | 2018 | European journal of medicinal chemistry, Jul-15, Volume: 155 | Cefiderocol (S-649266), A new siderophore cephalosporin exhibiting potent activities against Pseudomonas aeruginosa and other gram-negative pathogens including multi-drug resistant bacteria: Structure activity relationship. |
| AID341594 | Antibacterial activity against carbapenem-resistant blaKPC-encoding plasmid harboring Klebsiella pneumoniae 469 transformants producing KPC2, OXA4 and CTX-M-10 carbapenemases | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8 | Emergence of KPC-2 and KPC-3 in carbapenem-resistant Klebsiella pneumoniae strains in an Israeli hospital. |
| AID576274 | Antimicrobial activity against ESBL-positive Klebsiella pneumoniae 18260 by Etest | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | An ertapenem-resistant extended-spectrum-beta-lactamase-producing Klebsiella pneumoniae clone carries a novel OmpK36 porin variant. |
| AID556661 | Antimicrobial activity against multidrug resistant Enterobacter aerogenes isolate 16 by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Occurrence of efflux mechanism and cephalosporinase variant in a population of Enterobacter aerogenes and Klebsiella pneumoniae isolates producing extended-spectrum beta-lactamases. |
| AID518730 | Antimicrobial activity against Pseudomonas stutzeri clinical isolate expressing beta-lactamase DIM-1 by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Characterization of DIM-1, an integron-encoded metallo-beta-lactamase from a Pseudomonas stutzeri clinical isolate in the Netherlands. |
| AID532409 | Antibacterial activity against VIM-2 producing Pseudomonas aeruginosa clone B2 isolate VA-06X-38 by Etest method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | First countrywide survey of acquired metallo-beta-lactamases in gram-negative pathogens in Italy. |
| AID571902 | Antimicrobial activity against ISAba1 linked with the blaOXA-51-type beta-lactamase harboring Acinetobacter baumannii beta clonal group isolate 15 expressing ompA, adeB, adeM, aacA4, blaSHV-5 by Etest method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Correlation of antimicrobial resistance with beta-lactamases, the OmpA-like porin, and efflux pumps in clinical isolates of Acinetobacter baumannii endemic to New York City. |
| AID1225769 | Antibacterial activity against Klebsiella pneumoniae KP1010 expressing SHV-12 by broth microdilution method | 2015 | Journal of medicinal chemistry, May-14, Volume: 58, Issue:9 | Discovery of a Cyclic Boronic Acid β-Lactamase Inhibitor (RPX7009) with Utility vs Class A Serine Carbapenemases. |
| AID519004 | Antimicrobial activity against Serratia marcescens isolate CT-118 by broth macrodilution method | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | E240V substitution increases catalytic efficiency toward ceftazidime in a new natural TEM-type extended-spectrum beta-lactamase, TEM-149, from Enterobacter aerogenes and Serratia marcescens clinical isolates. |
| AID368723 | Ratio of Kcat to Km of Pseudomonas aeruginosa MK-1184 AmpC assessed as drug hydrolysis by spectrophotometry | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID422499 | Activity of Carnobacterium divergens BM4489 penicillinase Cad-1 at 1 uM enzyme concentration assessed as initial rate of hydrolysis by spectrophotometer | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | Genetic and biochemical characterization of CAD-1, a chromosomally encoded new class A penicillinase from Carnobacterium divergens. |
| AID565542 | Antibacterial activity against mexB, mexY and mexD expressing Pseudomonas aeruginosa isolate Paebeta-06 harboring A residue at 105 position in PDC- 2 and insertion of ISPa27 sequence in OprD gene by Etest method in presence of cloxacillin | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Molecular epidemiology and mechanisms of carbapenem resistance in Pseudomonas aeruginosa. |
| AID564457 | Antimicrobial activity against Pseudomonas aeruginosa isolate 878 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | In vivo efficacy of 1- and 2-gram human simulated prolonged infusions of doripenem against Pseudomonas aeruginosa. |
| AID495807 | Antimicrobial activity against Escherichia coli C600 2878 transconjugate expressing beta-lactamase VIM-19 by microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Novel VIM metallo-beta-lactamase variant from clinical isolates of Enterobacteriaceae from Algeria. |
| AID520388 | Ratio of Kcat to Km for Pseudomonas aeruginosa COL-1 metallo-beta lactamase VIM-2 | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Biochemical characterization of metallo-beta-lactamase VIM-11 from a Pseudomonas aeruginosa clinical strain. |
| AID524433 | Antimicrobial activity against Shigella isolate DH10B by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Identification and characterization of CTX-M-producing Shigella isolates in the United States. |
| AID495909 | Antimicrobial activity in Escherichia coli J53 transconjugate with Escherichia coli DIH-1 expressing natural plasmid containing beta-lactamase VIM-19 | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | VIM-19, a metallo-beta-lactamase with increased carbapenemase activity from Escherichia coli and Klebsiella pneumoniae. |
| AID532414 | Antibacterial activity against IMP-13 producing Pseudomonas aeruginosa clone C2 isolate NA-14X-02 by Etest method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | First countrywide survey of acquired metallo-beta-lactamases in gram-negative pathogens in Italy. |
| AID555450 | Antibacterial activity against Escherichia coli DH5alpha by Etest method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Genetic variability among ampC genes from acinetobacter genomic species 3. |
| AID519014 | Antimicrobial activity against Enterobacter aerogenes isolate SS-13 by broth macrodilution method | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | E240V substitution increases catalytic efficiency toward ceftazidime in a new natural TEM-type extended-spectrum beta-lactamase, TEM-149, from Enterobacter aerogenes and Serratia marcescens clinical isolates. |
| AID532178 | Antimicrobial activity against aac(6')-Ib-cr-negative Klebsiella pneumoniae SY22 harboring GyrA S83I, ParC S80I mutant, wild-type GyrB and qnrS genes by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | High prevalence of plasmid-mediated quinolone resistance genes qnr and aac(6')-Ib-cr in clinical isolates of Enterobacteriaceae from nine teaching hospitals in China. |
| AID556658 | Antimicrobial activity against multidrug resistant Enterobacter aerogenes isolate 13 by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Occurrence of efflux mechanism and cephalosporinase variant in a population of Enterobacter aerogenes and Klebsiella pneumoniae isolates producing extended-spectrum beta-lactamases. |
| AID564525 | Antimicrobial activity against Acinetobacter baumannii CIP70.10 by Etest method | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | Extended-spectrum cephalosporinase in Acinetobacter baumannii. |
| AID559896 | Antimicrobial activity against Klebsiella oxytoca KO279 harboring beta-lactamase OXY-1 by Etest method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | First detection of plasmid-encoded blaOXY beta-lactamase. |
| AID369643 | Antibacterial activity against Acinetobacter haemolyticus expressing carbapenemase-encoding blaOXA-40 gene by Etest method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Molecular epidemiology of imipenem-resistant Acinetobacter haemolyticus and Acinetobacter baumannii isolates carrying plasmid-mediated OXA-40 from a Portuguese hospital. |
| AID571898 | Antimicrobial activity against ISAba1 linked with the blaOXA-51-type beta-lactamase harboring Acinetobacter baumannii beta clonal group isolate 13 expressing ompA, adeB, adeM, aacA4, blaSHV-5 by Etest method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Correlation of antimicrobial resistance with beta-lactamases, the OmpA-like porin, and efflux pumps in clinical isolates of Acinetobacter baumannii endemic to New York City. |
| AID573336 | Antibacterial activity against ceftazidime-susceptible Enterobacteriaceae assessed as resistant isolates by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID1559401 | Half life in mouse at 10 mg/kg, iv after 1 to 6 hrs by LC-MS/MS analysis | 2020 | Journal of medicinal chemistry, 03-26, Volume: 63, Issue:6 | Discovery of Taniborbactam (VNRX-5133): A Broad-Spectrum Serine- and Metallo-β-lactamase Inhibitor for Carbapenem-Resistant Bacterial Infections. |
| AID546433 | Ratio of Kcat to Km for Pseudomonas aeruginosa PDC-5 by spectrophotometer | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Extended-spectrum cephalosporinases in Pseudomonas aeruginosa. |
| AID555215 | Antibacterial activity against Escherichia coli DH5alpha carrying ampC gene of Acinetobacter genomosp. 3 isolate 14 by Etest method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Genetic variability among ampC genes from acinetobacter genomic species 3. |
| AID559686 | Antibacterial activity against Escherichia coli Top10 | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | GES-11, a novel integron-associated GES variant in Acinetobacter baumannii. |
| AID372611 | Antibacterial activity against Escherichia coli DH5alpha by microdilution method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | TEM-158 (CMT-9), a new member of the CMT-type extended-spectrum beta-lactamases. |
| AID583088 | Ratio of Kcat to Km for Escherichia coli XL1-Blue wild-type IMP-1 beta-lactamase by spectrophotometer | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | Mutational analysis of VIM-2 reveals an essential determinant for metallo-beta-lactamase stability and folding. |
| AID520775 | Antibacterial activity against beta-lactamase KPC-2 producing Klebsiella pneumoniae isolate K1 to K9 by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Emergence of Serratia marcescens, Klebsiella pneumoniae, and Escherichia coli Isolates possessing the plasmid-mediated carbapenem-hydrolyzing beta-lactamase KPC-2 in intensive care units of a Chinese hospital. |
| AID285623 | Antimicrobial activity against Pseudomonas aeruginosa 8C4 tracheal isolates from mechanically ventilated chronic respiratory insufficiency patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID565528 | Antibacterial activity against mexB, mexY and mexD expressing Pseudomonas aeruginosa isolate Paebeta-07 harboring A residue at 105 position in PDC- 2 and insertion of ISPa27 sequence in OprD gene by Etest method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Molecular epidemiology and mechanisms of carbapenem resistance in Pseudomonas aeruginosa. |
| AID285654 | Antimicrobial activity against Pseudomonas aeruginosa 19D9 tracheal isolates from mechanically ventilated chronic respiratory insufficiency patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID529662 | Ratio of Kcat to Km for Pseudomonas aeruginosa 9551 beta-lactamase VIM-15 relative to cephaloridine | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | VIM-15 and VIM-16, two new VIM-2-like metallo-beta-lactamases in Pseudomonas aeruginosa isolates from Bulgaria and Germany. |
| AID565518 | Antibacterial activity against oprD, mexB, mexY and mexD expressing Pseudomonas aeruginosa isolate Paebeta-17 harboring A residue at 105 position in PDC- 3 by Etest method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Molecular epidemiology and mechanisms of carbapenem resistance in Pseudomonas aeruginosa. |
| AID368483 | Antibacterial activity against Pseudomonas aeruginosa 4352 producing beta lactamase AmpC by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID368525 | Ratio of Kcat to Km of Enterobacter cloacae 4080 AmpC (P99) assessed as drug hydrolysis by spectrophotometry | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID279183 | Antibacterial activity against Escherichia coli DH10B expressing recombinant beta lactamase LAP1 | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2 | Novel Ambler class A beta-lactamase LAP-1 and its association with the plasmid-mediated quinolone resistance determinant QnrS1. |
| AID508736 | Antibacterial activity against Pseudomonas aeruginosa PAO1 harboring acquired beta-lactamase OXA-144 by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2 | Activity of a new antipseudomonal cephalosporin, CXA-101 (FR264205), against carbapenem-resistant and multidrug-resistant Pseudomonas aeruginosa clinical strains. |
| AID424862 | Antimicrobial activity against carbapenem-susceptible Pseudomonas aeruginosa clinical isolate assessed as resistant isolates | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Molecular epidemiology and mechanisms of carbapenem resistance in Pseudomonas aeruginosa isolates from Spanish hospitals. |
| AID495907 | Antimicrobial activity in Escherichia coli TOP10 strain harbouring recombinant plasmid VIM-1 by Etest | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | VIM-19, a metallo-beta-lactamase with increased carbapenemase activity from Escherichia coli and Klebsiella pneumoniae. |
| AID529656 | Ratio of Kcat to Km for Pseudomonas aeruginosa 9551 beta-lactamase VIM-15 | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | VIM-15 and VIM-16, two new VIM-2-like metallo-beta-lactamases in Pseudomonas aeruginosa isolates from Bulgaria and Germany. |
| AID285439 | Antimicrobial activity against Citrobacter gillenii CIP 106783 after 18 hrs by disk diffusion method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Chromosome-encoded narrow-spectrum Ambler class A beta-lactamase GIL-1 from Citrobacter gillenii. |
| AID560089 | Bactericidal activity against Enterobacter cloacae isolate 4073 at 1/4 times MIC after 24 hrs by time kill analysis | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | In vitro activity of ceftaroline alone and in combination against clinical isolates of resistant gram-negative pathogens, including beta-lactamase-producing Enterobacteriaceae and Pseudomonas aeruginosa. |
| AID520383 | Antimicrobial activity Escherichia coli DH5alpha expressing metallo-beta-lactamase VIM-11 by agar macrodilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Biochemical characterization of metallo-beta-lactamase VIM-11 from a Pseudomonas aeruginosa clinical strain. |
| AID546411 | Antimicrobial activity against AmpC overproducing Pseudomonas aeruginosa isolate Pae-beta-28 with PDC-7 variant by Etest | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Extended-spectrum cephalosporinases in Pseudomonas aeruginosa. |
| AID555191 | Ratio of MIC for Pseudomonas aeruginosa PAO1 harboring deltaampD::lox deltaampDh2::lox deltaampDh3::lox deltanagZ::Gm to MIC for nagZ gene-deficient Pseudomonas aeruginosa PAO1 | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Inactivation of the glycoside hydrolase NagZ attenuates antipseudomonal beta-lactam resistance in Pseudomonas aeruginosa. |
| AID547535 | Antimicrobial activity against invasive Streptococcus anginosus obtained from non-cystic fibrosis patient assessed as non-susceptible isolates grown on brain heart infusion agar at 30 ug/ml after 24 hrs at 37 degC by disk diffusion method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Macrolide and clindamycin resistance in Streptococcus milleri group isolates from the airways of cystic fibrosis patients. |
| AID285670 | Antimicrobial activity against Pseudomonas aeruginosa 24E1 tracheal isolates from mechanically ventilated chronic respiratory insufficiency patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID373765 | Antibacterial activity against imipenem-resistant Acinetobacter baumannii abh13 by broth dilution method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | An OXA-66/OXA-51-like carbapenemase and possibly an efflux pump are associated with resistance to imipenem in Acinetobacter baumannii. |
| AID516146 | Antibacterial activity against Pulsotype J Acinetobacter genomosp. 3 isolate 15 containing IMP-1, OXA-58, ADC-18, ISAba1, ISAba3, IS1008, intI1 genetic elements by broth micro dilution | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Molecular characterization of beta-lactamase genes and their genetic structures in Acinetobacter genospecies 3 isolates in Taiwan. |
| AID323038 | Antimicrobial activity against extended-spectrum-beta-lactamase producing Escherichia coli assessed as percent resistant isolates | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Predictors of mortality in patients with bloodstream infections caused by extended-spectrum-beta-lactamase-producing Enterobacteriaceae: importance of inadequate initial antimicrobial treatment. |
| AID522028 | Antimicrobial activity against Escherichia coli isolate TOP10 by Etest method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Spread of OXA-48-encoding plasmid in Turkey and beyond. |
| AID559278 | Antimicrobial activity against rifampin-resistant Escherichia coli J53 transconjugated with Providencia stuartii Ps5 expressing beta-lactamase PER-1 by Etest | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Emergence of extended-spectrum beta-lactamase PER-1 in Proteus vulgaris and Providencia stuartii isolates from Algiers, Algeria. |
| AID372605 | Antibacterial activity against Escherichia coli BER1 producing beta-lactamase pI 5.2 and pI 5.4 by microdilution method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | TEM-158 (CMT-9), a new member of the CMT-type extended-spectrum beta-lactamases. |
| AID517962 | Antimicrobial activity against Enterobacteriaceae by broth dilution method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli. |
| AID368544 | Activity of Pseudomonas aeruginosa 18SH AmpC assessed as drug hydrolysis by spectrophotometry relative to cephaloridine | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID529577 | Ratio of Kcat to Km for Pseudomonas maltophilia ULA-511 beta-Lactamase L-1 | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Functional diversity among metallo-beta-lactamases: characterization of the CAR-1 enzyme of Erwinia carotovora. |
| AID373026 | Antimicrobial activity against imipenem and meropenem-resistant Acinetobacter baumannii isolate PUA1 by CLSI agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Molecular epidemiology of clinical isolates of carbapenem-resistant Acinetobacter spp. from Chinese hospitals. |
| AID562473 | Antimicrobial activity against rifampicin-resistant Escherichia coli A15 transconjugant expressing beta-lactamase KPC-2/TEM-1 by Etest | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | Emergence of Klebsiella pneumoniae ST258 with KPC-2 in Poland. |
| AID522026 | Antimicrobial activity against Escherichia coli isolate J53 harboring pEcA containing beta-lactamase OXA-48 located within transposon Tn1999.2 by Etest method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Spread of OXA-48-encoding plasmid in Turkey and beyond. |
| AID532193 | Antimicrobial activity against aac(6')-Ib-cr-positive Citrobacter freundii TJ15T harboring wild-type GyrA, ParC, GyrB genes by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | High prevalence of plasmid-mediated quinolone resistance genes qnr and aac(6')-Ib-cr in clinical isolates of Enterobacteriaceae from nine teaching hospitals in China. |
| AID405792 | Inhibition of bocillin FL binding to Pseudomonas aeruginosa PAO1 penicillin-binding protein 5/6 | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | Binding of ceftobiprole and comparators to the penicillin-binding proteins of Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Streptococcus pneumoniae. |
| AID560132 | Activity of recombinant beta-lactamase RTG4 expressed in Escherichia coli TOP10 by nitrocefin hydrolysis assay relative to benzylpenicillin | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Genetic and biochemical characterization of the first extended-spectrum CARB-type beta-lactamase, RTG-4, from Acinetobacter baumannii. |
| AID554393 | Antimicrobial activity against Pseudomonas aeruginosa isolate 3020R obtained from cystic fibrosis patient by disk diffusion method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Efflux unbalance in Pseudomonas aeruginosa isolates from cystic fibrosis patients. |
| AID519643 | Antimicrobial activity against Escherichia coli EPI300 transformant harboring pCC1 by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Convergent in vivo and in vitro selection of ceftazidime resistance mutations at position 167 of CTX-M-3 beta-lactamase in hypermutable Escherichia coli strains. |
| AID368530 | Ratio of Kcat to Km of Enterobacter cloacae 908R AmpC assessed as drug hydrolysis by spectrophotometry relative to cephaloridine | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID761214 | Antibacterial activity against Acinetobacter baumannii AB-3167 by broth microdilution method | 2013 | Journal of medicinal chemistry, Jul-11, Volume: 56, Issue:13 | Pyridone-conjugated monobactam antibiotics with gram-negative activity. |
| AID498835 | Antimicrobial activity against carbapenem-resistant Klebsiella pneumoniae PU4 deficient in SHV-1, DHA-1, ompK35/36 by CLSI method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Phenotypic and genotypic characterization of Enterobacteriaceae with decreased susceptibility to carbapenems: results from large hospital-based surveillance studies in China. |
| AID322321 | Antibacterial activity against Escherichia coli DH5 alpha-URA5776 isolates expressing CTX-M-14 enzyme by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Spread of extended-spectrum beta-lactamase CTX-M-producing escherichia coli clinical isolates in community and nosocomial environments in Portugal. |
| AID556700 | Antimicrobial activity against multidrug resistant Escherichia coli ATCC 35218 harboring pDrive plasmid expressing ampC gene by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Occurrence of efflux mechanism and cephalosporinase variant in a population of Enterobacter aerogenes and Klebsiella pneumoniae isolates producing extended-spectrum beta-lactamases. |
| AID571896 | Antimicrobial activity against ISAba1 linked with the blaOXA-51-type beta-lactamase harboring Acinetobacter baumannii beta clonal group isolate 12 expressing ompA, adeB, adeM, aacA4, aacC2, blaSHV-5 by Etest method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Correlation of antimicrobial resistance with beta-lactamases, the OmpA-like porin, and efflux pumps in clinical isolates of Acinetobacter baumannii endemic to New York City. |
| AID546415 | Antimicrobial activity against AmpC overproducing Pseudomonas aeruginosa isolate Pae-beta-32 with PDC-10 variant by Etest | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Extended-spectrum cephalosporinases in Pseudomonas aeruginosa. |
| AID584565 | Antimicrobial activity against Acinetobacter lwoffii isolate L expressing beta-lactamase OXA-58 isolated from tracheal secretion of patient by vitek 2 system | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | In vivo selection of a missense mutation in adeR and conversion of the novel blaOXA-164 gene into blaOXA-58 in carbapenem-resistant Acinetobacter baumannii isolates from a hospitalized patient. |
| AID546420 | Antimicrobial activity against Pseudomonas aeruginosa KG2505a harboring recombinant pBB-PDC-5 by Etest | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Extended-spectrum cephalosporinases in Pseudomonas aeruginosa. |
| AID1373283 | Antimicrobial activity against Escherichia coli expressing beta-lactamase GES-1 by CLSI broth microdilution method | 2018 | Bioorganic & medicinal chemistry letters, 02-15, Volume: 28, Issue:4 | Optimization of novel monobactams with activity against carbapenem-resistant Enterobacteriaceae - Identification of LYS228. |
| AID573365 | Antibacterial activity against ceftazidime-susceptible Morganella morganii assessed as susceptible isolates by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID498822 | Antimicrobial activity against Klebsiella pneumoniae WH77 expressing IMP-4, TEM-1, SHV-14, CTX-M-3, qnrS1 by CLSI method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Phenotypic and genotypic characterization of Enterobacteriaceae with decreased susceptibility to carbapenems: results from large hospital-based surveillance studies in China. |
| AID549331 | Antimicrobial activity against Escherichia coli isolate 32 harboring bla CTX-M-3a gene by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | blaCTX-M genes in escherichia coli strains from Croatian Hospitals are located in new (blaCTX-M-3a) and widely spread (blaCTX-M-3a and blaCTX-M-15) genetic structures. |
| AID285672 | Antimicrobial activity against Pseudomonas aeruginosa 24E5 tracheal isolates from mechanically ventilated chronic respiratory insufficiency patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID530326 | Antimicrobial activity against Escherichia coli XL1-Blue harboring pUCP carrying VIM-1 gene by Etest method | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Characterization of the new metallo-beta-lactamase VIM-13 and its integron-borne gene from a Pseudomonas aeruginosa clinical isolate in Spain. |
| AID625285 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for hepatic necrosis | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID524932 | Antimicrobial activity against Escherichia coli MI1443 harboring V27A and Q38R mutations in beta lactamase CTX-M-10 by E-test | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Mutational events in cefotaximase extended-spectrum beta-lactamases of the CTX-M-1 cluster involved in ceftazidime resistance. |
| AID528528 | Antimicrobial activity against penicillin-resistant Streptococcus agalactiae B10 by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | First molecular characterization of group B streptococci with reduced penicillin susceptibility. |
| AID518463 | Antimicrobial activity against Klebsiella pneumoniae 1338665 assessed as number of passages required for MIC to rise above 4 times original MIC | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli. |
| AID252634 | Bacterial susceptibility induced by D113 mutation in Escherichia coli OmpF | 2005 | Journal of medicinal chemistry, Mar-10, Volume: 48, Issue:5 | Beta-lactam screening by specific residues of the OmpF eyelet. |
| AID511687 | Antimicrobial activity against beta-lactam resistant Pseudomonas aeruginosa PA01 deficient in dacB gene by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Activity of a new cephalosporin, CXA-101 (FR264205), against beta-lactam-resistant Pseudomonas aeruginosa mutants selected in vitro and after antipseudomonal treatment of intensive care unit patients. |
| AID535855 | Antimicrobial activity against aac(6')-Ib-cr-positive Klebsiella pneumoniae GZ40 harboring GyrA S83I, ParC S80I mutant, wild-type GyrB and qnrB genes by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | High prevalence of plasmid-mediated quinolone resistance genes qnr and aac(6')-Ib-cr in clinical isolates of Enterobacteriaceae from nine teaching hospitals in China. |
| AID285579 | Antimicrobial activity against Pseudomonas aeruginosa IA5 tracheal isolates from mechanically ventilated tuberculosis patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID565520 | Antibacterial activity against mexB, mexY and mexD expressing Pseudomonas aeruginosa isolate Paebeta-15 harboring A residue at 105 position in PDC- 2 and polymorphic OprD gene by Etest method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Molecular epidemiology and mechanisms of carbapenem resistance in Pseudomonas aeruginosa. |
| AID544950 | Antimicrobial activity against Escherichia coli expressing beta-lactamase AmpC by Etest | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Characterization and sequence analysis of extended-spectrum-{beta}-lactamase-encoding genes from Escherichia coli, Klebsiella pneumoniae, and Proteus mirabilis isolates collected during tigecycline phase 3 clinical trials. |
| AID554435 | Ratio of MIC for Pseudomonas aeruginosa 2716 to MIC for Pseudomonas aeruginosa PAO1 | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Efflux unbalance in Pseudomonas aeruginosa isolates from cystic fibrosis patients. |
| AID528845 | Antimicrobial activity against methicillin-resistant Staphylococcus epidermidis isolated from ICU patient wound assessed as resistant isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Antimicrobial-resistant pathogens in intensive care units in Canada: results of the Canadian National Intensive Care Unit (CAN-ICU) study, 2005-2006. |
| AID368521 | Ratio of Kcat to Km of Enterobacter cloacae 4092 AmpC (E2) assessed as drug hydrolysis by spectrophotometry | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID525507 | fT>MIC in Pseudomonas aeruginosa infected patient | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Clinical pharmacodynamics of cefepime in patients infected with Pseudomonas aeruginosa. |
| AID508735 | Antibacterial activity against Pseudomonas aeruginosa PAO1 harboring acquired beta-lactamase OXA-2 by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2 | Activity of a new antipseudomonal cephalosporin, CXA-101 (FR264205), against carbapenem-resistant and multidrug-resistant Pseudomonas aeruginosa clinical strains. |
| AID285640 | Antimicrobial activity against Pseudomonas aeruginosa 13D11 tracheal isolates from mechanically ventilated chronic respiratory insufficiency patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID583018 | Antimicrobial activity against OmpC/OmpF porin deficient Escherichia coli HB4 transformed with Escherichia coli pGLK-1 plasmid carrying FOX-1 by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Phenotypic and biochemical comparison of the carbapenem-hydrolyzing activities of five plasmid-borne AmpC β-lactamases. |
| AID323690 | Antibacterial activity against TEM92 ESBL-producing Acinetobacter baumannii by CLSI method | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Spread in an Italian hospital of a clonal Acinetobacter baumannii strain producing the TEM-92 extended-spectrum beta-lactamase. |
| AID519737 | Antibacterial activity against Escherichia coli DH5alpha expressing Klebsiella pneumoniae beta-lactamase SHV-1 by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | The Lys234Arg substitution in the enzyme SHV-72 is a determinant for resistance to clavulanic acid inhibition. |
| AID523890 | Antimicrobial activity against Acinetobacter baumannii ATCC 15151 by Etest | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Genetic basis of multidrug resistance in Acinetobacter clinical isolates in Taiwan. |
| AID285578 | Antimicrobial activity against Pseudomonas aeruginosa P21.23 tracheal isolates from mechanically ventilated tuberculosis patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID556659 | Antimicrobial activity against multidrug resistant Enterobacter aerogenes isolate 14 by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Occurrence of efflux mechanism and cephalosporinase variant in a population of Enterobacter aerogenes and Klebsiella pneumoniae isolates producing extended-spectrum beta-lactamases. |
| AID559689 | Antibacterial activity against ESBL-positive and OmpF and OmpC porin-deficient Escherichia coli HB4 harboring plasmid AT517 | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | GES-11, a novel integron-associated GES variant in Acinetobacter baumannii. |
| AID394492 | Antimicrobial activity against Escherichia coli MC4100 harboring pA-acc4 plasmid by agar dilution technique | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10 | Plasmid-encoded ACC-4, an extended-spectrum cephalosporinase variant from Escherichia coli. |
| AID1373303 | Antimicrobial activity against Escherichia coli expressing beta-lactamase TEM-121 by CLSI broth microdilution method | 2018 | Bioorganic & medicinal chemistry letters, 02-15, Volume: 28, Issue:4 | Optimization of novel monobactams with activity against carbapenem-resistant Enterobacteriaceae - Identification of LYS228. |
| AID565769 | Antimicrobial activity against Pseudomonas aeruginosa OC 12070 expressing 151 fold elevated mexX expression and 127 fold elevated mexY expression by broth macrodilution method | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | Differential selection of single-step AmpC or efflux mutants of Pseudomonas aeruginosa by using cefepime, ceftazidime, or ceftobiprole. |
| AID283320 | Antimicrobial activity against Klebsiella pneumoniae KPN15-NL | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3 | Detection of a new SHV-type extended-spectrum beta-lactamase, SHV-31, in a Klebsiella pneumoniae strain causing a large nosocomial outbreak in The Netherlands. |
| AID555666 | Antimicrobial activity against Escherichia coli DH10B harboring natural plasmid pWES-1 carrying CTX-M-53 gene by disk diffusion method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Novel plasmid-encoded ceftazidime-hydrolyzing CTX-M-53 extended-spectrum beta-lactamase from Salmonella enterica serotypes Westhampton and Senftenberg. |
| AID1373305 | Antimicrobial activity against Escherichia coli expressing beta-lactamase IMP-1 by CLSI broth microdilution method | 2018 | Bioorganic & medicinal chemistry letters, 02-15, Volume: 28, Issue:4 | Optimization of novel monobactams with activity against carbapenem-resistant Enterobacteriaceae - Identification of LYS228. |
| AID1225776 | Antibacterial activity against Klebsiella oxytoca KX1001 expressing OXA-2 by broth microdilution method | 2015 | Journal of medicinal chemistry, May-14, Volume: 58, Issue:9 | Discovery of a Cyclic Boronic Acid β-Lactamase Inhibitor (RPX7009) with Utility vs Class A Serine Carbapenemases. |
| AID583093 | Antimicrobial activity against Escherichia coli XL1-Blue harboring pBC-SK plasmid by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | Mutational analysis of VIM-2 reveals an essential determinant for metallo-beta-lactamase stability and folding. |
| AID1139540 | Antibacterial activity against Escherichia coli DH5alpha expressing beta-lactamase TEM-1 by CLSI broth microdilution method | 2014 | Journal of medicinal chemistry, May-08, Volume: 57, Issue:9 | Siderophore receptor-mediated uptake of lactivicin analogues in gram-negative bacteria. |
| AID1361166 | Antimicrobial activity against AmpC overproducing Pseudomonas aeruginosa SR24-12 in presence of human apo-transferrin by broth microdilution method | 2018 | European journal of medicinal chemistry, Jul-15, Volume: 155 | Cefiderocol (S-649266), A new siderophore cephalosporin exhibiting potent activities against Pseudomonas aeruginosa and other gram-negative pathogens including multi-drug resistant bacteria: Structure activity relationship. |
| AID285595 | Antimicrobial activity against Pseudomonas aeruginosa 1B9 tracheal isolates from mechanically ventilated tuberculosis patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID528522 | Antimicrobial activity against Streptococcus pneumoniae ATCC 49619 by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | First molecular characterization of group B streptococci with reduced penicillin susceptibility. |
| AID561672 | Antimicrobial activity against Pseudomonas aeruginosa isolate OC16830 harboring plasmid MexZ expressing mexXY gene by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Effect of MexXY overexpression on ceftobiprole susceptibility in Pseudomonas aeruginosa. |
| AID498842 | Antimicrobial activity against carbapenem-resistant Klebsiella pneumoniae CY75 deficient in SHV-11, DHA-1, ompK35/36 by CLSI method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Phenotypic and genotypic characterization of Enterobacteriaceae with decreased susceptibility to carbapenems: results from large hospital-based surveillance studies in China. |
| AID295841 | Antimicrobial activity against Escherichia coli A1 by disk diffusion method at 300 ug/disc | 2007 | European journal of medicinal chemistry, Jul, Volume: 42, Issue:7 | Synthesis of some novel heterocyclic compounds derived from diflunisal hydrazide as potential anti-infective and anti-inflammatory agents. |
| AID546407 | Antimicrobial activity against AmpC overproducing Pseudomonas aeruginosa isolate Pae-beta-24 with PDC-5 variant by Etest | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Extended-spectrum cephalosporinases in Pseudomonas aeruginosa. |
| AID556696 | Antimicrobial activity against multidrug resistant Escherichia coli DH5[alpha] harboring pDrive plasmid expressing ampC gene by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Occurrence of efflux mechanism and cephalosporinase variant in a population of Enterobacter aerogenes and Klebsiella pneumoniae isolates producing extended-spectrum beta-lactamases. |
| AID495809 | Antimicrobial activity against Escherichia coli DH5alpha harbouring plasmid BK-VIM-19 expressing beta-lactamase VIM-19 by microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Novel VIM metallo-beta-lactamase variant from clinical isolates of Enterobacteriaceae from Algeria. |
| AID405635 | Antibacterial activity against Escherichia coli MC4100 by CLSI method | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | Binding of ceftobiprole and comparators to the penicillin-binding proteins of Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Streptococcus pneumoniae. |
| AID535691 | Antimicrobial activity against beta-lactamase CTX-M-15-producing fluoroquinolone-resistant Escherichia coli FMV5825 expressing qnrB2 and aac(6')-Ib-cr and harboring gyrA Ser83Ile and Asp87Asn mutant gene and ParC Ser80Ile and Glu84Val mutant gene obtained | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Detection of the pandemic O25-ST131 human virulent Escherichia coli CTX-M-15-producing clone harboring the qnrB2 and aac(6')-Ib-cr genes in a dog. |
| AID532166 | Antimicrobial activity against aac(6')-Ib-cr-positive Citrobacter freundii PU55 harboring GyrA T83I, ParC S80I mutant, wild-type GyrB, qnrA genes by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | High prevalence of plasmid-mediated quinolone resistance genes qnr and aac(6')-Ib-cr in clinical isolates of Enterobacteriaceae from nine teaching hospitals in China. |
| AID567286 | Antimicrobial activity against Acinetobacter baumannii expressing ESAC beta-lactamase by Etest method | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | Extended-spectrum cephalosporinase in Acinetobacter baumannii. |
| AID521349 | Antimicrobial activity against Streptococcus pneumoniae isolate 909 obtained from bronchoalveolar lavage fluid of patient | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Highly variable penicillin resistance determinants PBP 2x, PBP 2b, and PBP 1a in isolates of two Streptococcus pneumoniae clonal groups, Poland 23F-16 and Poland 6B-20. |
| AID528741 | Antimicrobial activity against penicillin-resistant Streptococcus agalactiae ATCC BAA-611 harboring PBP-2X V405A mutant gene by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | First molecular characterization of group B streptococci with reduced penicillin susceptibility. |
| AID535143 | Antimicrobial activity against imipenem non-susceptible Pseudomonas aeruginosa assessed as susceptible isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activity of doripenem, a carbapenem for the treatment of challenging infections caused by gram-negative bacteria, against recent clinical isolates from the United States. |
| AID340726 | Antimicrobial activity against Enterobacter isolates producing extended-spectrum beta-lactamase CTX-M-15 by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8 | Extended-spectrum beta-lactamases of the CTX-M type now in Switzerland. |
| AID561657 | Antimicrobial activity against Pseudomonas aeruginosa isolate OC14805 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Effect of MexXY overexpression on ceftobiprole susceptibility in Pseudomonas aeruginosa. |
| AID368507 | Ratio of Kcat to Km of Escherichia coli KPC2 assessed as drug hydrolysis by spectrophotometry | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID373053 | Antimicrobial activity against Escherichia coli DH10B by agar-dilution technique | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Molecular and biochemical characterization of the chromosome-encoded class A beta-lactamase BCL-1 from Bacillus clausii. |
| AID558041 | Antimicrobial activity against blaKPC-positive Klebsiella pneumoniae S4 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Genetic organization of transposase regions surrounding blaKPC carbapenemase genes on plasmids from Klebsiella strains isolated in a New York City hospital. |
| AID555554 | Antimicrobial activity against Pseudomonas aeruginosa isolate M136074 expressing IMP-22 beta lactamase gene by Etest | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | First organisms with acquired metallo-beta-lactamases (IMP-13, IMP-22, and VIM-2) reported in Austria. |
| AID1318936 | Antibacterial activity against multidrug-resistant/tobramycin-susceptible Pseudomonas aeruginosa isolate 84745 | 2016 | Journal of medicinal chemistry, 09-22, Volume: 59, Issue:18 | Hybrid Antibiotic Overcomes Resistance in P. aeruginosa by Enhancing Outer Membrane Penetration and Reducing Efflux. |
| AID567315 | Antimicrobial activity against SHV-12 ESBL producing Pseudomonas aeruginosa isolate 2206 isolated from burn patient by broth microdilution method in presence of beta-lactamase inhibitor clavulanic acid | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Acquisition of a transposon encoding extended-spectrum beta-lactamase SHV-12 by Pseudomonas aeruginosa isolates during the clinical course of a burn patient. |
| AID583645 | Neurotoxicity in febrile neutropenic patient assessed as confusion at 2 g administered as 30 mins infusion every 8 hrs | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | High cefepime plasma concentrations and neurological toxicity in febrile neutropenic patients with mild impairment of renal function. |
| AID509868 | Antibacterial activity against Acinetobacter baumannii isolate 2898 isolated from human ankle | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Acinetobacter baumannii increases tolerance to antibiotics in response to monovalent cations. |
| AID558793 | Antimicrobial activity against extended spectrum beta-lactamase-expressing Escherichia coli assessed as percent susceptible isolates by CLSI method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Emergence of high levels of extended-spectrum-beta-lactamase-producing gram-negative bacilli in the Asia-Pacific region: data from the Study for Monitoring Antimicrobial Resistance Trends (SMART) program, 2007. |
| AID285665 | Antimicrobial activity against Pseudomonas aeruginosa 22E1 tracheal isolates from mechanically ventilated chronic respiratory insufficiency patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID560094 | Bactericidal activity against Escherichia coli isolate 5411 at 1/4 times MIC after 24 hrs by time kill analysis | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | In vitro activity of ceftaroline alone and in combination against clinical isolates of resistant gram-negative pathogens, including beta-lactamase-producing Enterobacteriaceae and Pseudomonas aeruginosa. |
| AID373050 | Antimicrobial activity against Bacillus clausii NR expressing beta-lactamase BCL1 by agar-dilution technique | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Molecular and biochemical characterization of the chromosome-encoded class A beta-lactamase BCL-1 from Bacillus clausii. |
| AID530601 | Antibacterial activity against Escherichia coli J53 harboring plasmid pAM carrying beta-lactamase PER-1 by Etest | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Expanded-spectrum beta-lactamase PER-1 in an environmental Aeromonas media isolate from Switzerland. |
| AID495509 | Antibacterial activity against Acinetobacter baumannii BM4587 by antimicrobial susceptibility assay | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Screening and quantification of the expression of antibiotic resistance genes in Acinetobacter baumannii with a microarray. |
| AID405633 | Inhibition of bocillin FL binding to Pseudomonas aeruginosa PAO1 penicillin-binding protein 1b | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | Binding of ceftobiprole and comparators to the penicillin-binding proteins of Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Streptococcus pneumoniae. |
| AID529197 | Antibacterial activity against ESBL-producing Escherichia coli assessed as resistant isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Comparison of antimicrobial resistance profiles among extended-spectrum-beta-lactamase-producing and acquired AmpC beta-lactamase-producing Escherichia coli isolates from Canadian intensive care units. |
| AID521999 | Antimicrobial activity against Klebsiella pneumoniae isolate Kp6A expressing beta-lactamase OXA-48 and TEM-150 by Etest method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Spread of OXA-48-encoding plasmid in Turkey and beyond. |
| AID625291 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for liver function tests abnormal | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID573191 | Antimicrobial activity against mutS::lox,nfxB gene-deficient Pseudomonas aeruginosa PAOMSNB biofilm by Etest method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Azithromycin in Pseudomonas aeruginosa biofilms: bactericidal activity and selection of nfxB mutants. |
| AID564465 | Antimicrobial activity against Pseudomonas aeruginosa isolate 971 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | In vivo efficacy of 1- and 2-gram human simulated prolonged infusions of doripenem against Pseudomonas aeruginosa. |
| AID625287 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for hepatomegaly | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID285622 | Antimicrobial activity against Pseudomonas aeruginosa 8A12 tracheal isolates from mechanically ventilated chronic respiratory insufficiency patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID529645 | Antimicrobial activity against Pseudomonas aeruginosa 166301 expressing beta-lactamase VIM-16 obtained from urine of patient by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | VIM-15 and VIM-16, two new VIM-2-like metallo-beta-lactamases in Pseudomonas aeruginosa isolates from Bulgaria and Germany. |
| AID238858 | Binding affinity against membrane transport protein PEPT1 in human Caco-2 cells | 2005 | Journal of medicinal chemistry, Jun-30, Volume: 48, Issue:13 | Three-dimensional quantitative structure-activity relationship analyses of beta-lactam antibiotics and tripeptides as substrates of the mammalian H+/peptide cotransporter PEPT1. |
| AID558786 | Antimicrobial activity against Citrobacter freundii assessed as percent susceptible isolates by CLSI method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Emergence of high levels of extended-spectrum-beta-lactamase-producing gram-negative bacilli in the Asia-Pacific region: data from the Study for Monitoring Antimicrobial Resistance Trends (SMART) program, 2007. |
| AID495843 | Ratio of Kcat to Km for Escherichia coli DH10B beta-lactamase VIM-2 by microacidimetric method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Novel VIM metallo-beta-lactamase variant from clinical isolates of Enterobacteriaceae from Algeria. |
| AID564464 | Antimicrobial activity against Pseudomonas aeruginosa isolate 968 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | In vivo efficacy of 1- and 2-gram human simulated prolonged infusions of doripenem against Pseudomonas aeruginosa. |
| AID405793 | Antibacterial activity against Pseudomonas aeruginosa PAO1 after 1.5 hrs by CLSI method | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | Binding of ceftobiprole and comparators to the penicillin-binding proteins of Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Streptococcus pneumoniae. |
| AID583098 | Antimicrobial activity against Escherichia coli XL1-Blue harboring pLBII-VIM-2 plasmid expressing VIM-2 beta-lactamase by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | Mutational analysis of VIM-2 reveals an essential determinant for metallo-beta-lactamase stability and folding. |
| AID547529 | Antimicrobial activity against Streptococcus intermedius obtained from patient with cystic fibrosis assessed as non-susceptible isolates grown on brain heart infusion agar at 30 ug/ml after 24 hrs at 37 degC by disk diffusion method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Macrolide and clindamycin resistance in Streptococcus milleri group isolates from the airways of cystic fibrosis patients. |
| AID534865 | Antimicrobial activity against Non-ESBL Proteus mirabilis assessed as intermediate isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activity of doripenem, a carbapenem for the treatment of challenging infections caused by gram-negative bacteria, against recent clinical isolates from the United States. |
| AID325193 | Antibacterial activity against AmpC hyperproducing Pseudomonas aeruginosa SR24-12 by standard serial agar dilution method | 2008 | Bioorganic & medicinal chemistry, Feb-15, Volume: 16, Issue:4 | A novel series of parenteral cephalosporins exhibiting potent activities against both Pseudomonas aeruginosa and other gram-negative pathogens. Part 2: Synthesis and structure-activity relationships. |
| AID520879 | Antibacterial activity against Achromobacter xylosoxidans DUC by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Characterization of a naturally occurring class D beta-lactamase from Achromobacter xylosoxidans. |
| AID520799 | Antimicrobial activity against CTX-M-59 producing Klebsiella pneumoniae with PFGE pulsotype G by Etest | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Multiclonal outbreak of Klebsiella pneumoniae producing extended-spectrum beta-lactamase CTX-M-2 and novel variant CTX-M-59 in a neonatal intensive care unit in Brazil. |
| AID368512 | Ratio of Kcat to Km of Serratia marcescens SME3 assessed as drug hydrolysis by spectrophotometry relative to cephaloridine | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID285600 | Antimicrobial activity against Pseudomonas aeruginosa 2C2 tracheal isolates from mechanically ventilated tuberculosis patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID1079946 | Presence of at least one case with successful reintroduction. [column 'REINT' in source] | |||
| AID283544 | Antibacterial activity against Pseudomonas aeruginosa FE57GZ with inactivated rplY, nuoG and mexZ genes by microdilution method | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3 | Cumulative effects of several nonenzymatic mechanisms on the resistance of Pseudomonas aeruginosa to aminoglycosides. |
| AID531318 | Ratio of Kcat to Km for Escherichia coli beta-lactamase VIM-1 by spectrophotometry | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Kinetic characterization of VIM-7, a divergent member of the VIM metallo-beta-lactamase family. |
| AID520709 | Antibacterial activity against Acinetobacter baumannii MAD by disk diffusion method | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Carbapenem-resistant Acinetobacter baumannii isolates from Tunisia producing the OXA-58-like carbapenem-hydrolyzing oxacillinase OXA-97. |
| AID520776 | Antibacterial activity against beta-lactamase KPC-2 producing Serratia marcescens isolate S1 to S21 by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Emergence of Serratia marcescens, Klebsiella pneumoniae, and Escherichia coli Isolates possessing the plasmid-mediated carbapenem-hydrolyzing beta-lactamase KPC-2 in intensive care units of a Chinese hospital. |
| AID508489 | Antimicrobial activity against Pseudomonas aeruginosa isolate K44-24 producing metallo-beta-lactamase IMP14 by Etest | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Molecular epidemiology of metallo-beta-lactamase-producing Pseudomonas aeruginosa isolates from Norway and Sweden shows import of international clones and local clonal expansion. |
| AID532395 | Antibacterial activity against VIM-1 producing Pseudomonas aeruginosa clone A3 isolate NA-14X-34 by Etest method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | First countrywide survey of acquired metallo-beta-lactamases in gram-negative pathogens in Italy. |
| AID1373319 | Antimicrobial activity against Escherichia coli expressing beta-lactamase Oxa-48 by CLSI broth microdilution method | 2018 | Bioorganic & medicinal chemistry letters, 02-15, Volume: 28, Issue:4 | Optimization of novel monobactams with activity against carbapenem-resistant Enterobacteriaceae - Identification of LYS228. |
| AID499053 | Antimicrobial activity against carbapenem-resistant Escherichia coli PU96 deficient in TEM-1, CTX-M-14, CMY-2, ompC/F by CLSI method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Phenotypic and genotypic characterization of Enterobacteriaceae with decreased susceptibility to carbapenems: results from large hospital-based surveillance studies in China. |
| AID283220 | Antimicrobial activity against Pseudomonas aeruginosa PA0905 | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3 | Coproduction of novel 16S rRNA methylase RmtD and metallo-beta-lactamase SPM-1 in a panresistant Pseudomonas aeruginosa isolate from Brazil. |
| AID285677 | Antimicrobial activity against Pseudomonas aeruginosa 29F6 tracheal isolates from mechanically ventilated chronic respiratory insufficiency patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID532400 | Antibacterial activity against VIM-1 producing Pseudomonas aeruginosa clone D2 isolate VA-06X-17 by Etest method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | First countrywide survey of acquired metallo-beta-lactamases in gram-negative pathogens in Italy. |
| AID549333 | Antimicrobial activity against Escherichia coli isolate 36 harboring bla CTX-M-3a gene by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | blaCTX-M genes in escherichia coli strains from Croatian Hospitals are located in new (blaCTX-M-3a) and widely spread (blaCTX-M-3a and blaCTX-M-15) genetic structures. |
| AID564458 | Antimicrobial activity against Pseudomonas aeruginosa isolate 896 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | In vivo efficacy of 1- and 2-gram human simulated prolonged infusions of doripenem against Pseudomonas aeruginosa. |
| AID561441 | Antibacterial activity against Escherichia coli 1285 harboring beta-lactamase CMY-33 gene by Etest method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Reduced susceptibility to cefepime among Escherichia coli clinical isolates producing novel variants of CMY-2 beta-lactamase. |
| AID565279 | Antibacterial activity against mexB and mexY expressing Pseudomonas aeruginosa PA-A1 harboring GyrA T83I, ParC S87L and IS1001 insertion at position 629 in OprD gene by Etest method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Nosocomial spread of colistin-only-sensitive sequence type 235 Pseudomonas aeruginosa isolates producing the extended-spectrum beta-lactamases GES-1 and GES-5 in Spain. |
| AID394495 | Antimicrobial activity against Escherichia coli MC4100 harboring pB-acc4 plasmid by agar dilution technique | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10 | Plasmid-encoded ACC-4, an extended-spectrum cephalosporinase variant from Escherichia coli. |
| AID1139536 | Antibacterial activity against Escherichia coli DH5alpha by CLSI broth microdilution method | 2014 | Journal of medicinal chemistry, May-08, Volume: 57, Issue:9 | Siderophore receptor-mediated uptake of lactivicin analogues in gram-negative bacteria. |
| AID373757 | Antibacterial activity against imipenem-susceptible Acinetobacter baumannii ab1308 by broth dilution method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | An OXA-66/OXA-51-like carbapenemase and possibly an efflux pump are associated with resistance to imipenem in Acinetobacter baumannii. |
| AID565531 | Antibacterial activity against oprD, mexB, mexY and mexD expressing Pseudomonas aeruginosa isolate Paebeta-04 harboring A residue at 105 position in PDC- 2 by Etest method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Molecular epidemiology and mechanisms of carbapenem resistance in Pseudomonas aeruginosa. |
| AID567306 | Antimicrobial activity against SHV-12 ESBL producing Pseudomonas aeruginosa isolate 2204 isolated from burn patient by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Acquisition of a transposon encoding extended-spectrum beta-lactamase SHV-12 by Pseudomonas aeruginosa isolates during the clinical course of a burn patient. |
| AID560122 | Antimicrobial activity against Acinetobacter baumannii CIP70.10 harboring beta-lactamase RTG4 gene by disk diffusion method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Genetic and biochemical characterization of the first extended-spectrum CARB-type beta-lactamase, RTG-4, from Acinetobacter baumannii. |
| AID558042 | Antimicrobial activity against blaKPC-positive Klebsiella pneumoniae S5 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Genetic organization of transposase regions surrounding blaKPC carbapenemase genes on plasmids from Klebsiella strains isolated in a New York City hospital. |
| AID582977 | Antimicrobial activity against ampD::lox, ampDh2::lox and ampDh3::lox gene-deficient Pseudomonas aeruginosa PAO1 by Etest method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | NagZ inactivation prevents and reverts beta-lactam resistance, driven by AmpD and PBP 4 mutations, in Pseudomonas aeruginosa. |
| AID285641 | Antimicrobial activity against Pseudomonas aeruginosa 13E1 tracheal isolates from mechanically ventilated chronic respiratory insufficiency patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID561384 | Antibacterial activity against Escherichia coli isolate ARL05-909 harboring beta-lactamase CMY 29 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | CMY-29 and CMY-30, two novel plasmid-mediated AmpC beta-lactamases. |
| AID373773 | Antibacterial activity against imipenem-resistant Acinetobacter baumannii abh37 by broth dilution method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | An OXA-66/OXA-51-like carbapenemase and possibly an efflux pump are associated with resistance to imipenem in Acinetobacter baumannii. |
| AID573372 | Antibacterial activity against ceftazidime-susceptible Serratia marcescens assessed as resistant isolates by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID559903 | Antimicrobial activity against Escherichia coli TF-KO281 harboring beta-lactamase OXY-1 by Etest method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | First detection of plasmid-encoded blaOXY beta-lactamase. |
| AID540220 | Clearance in human after iv administration | 2005 | Journal of pharmaceutical sciences, Jul, Volume: 94, Issue:7 | Extrapolation of human pharmacokinetic parameters from rat, dog, and monkey data: Molecular properties associated with extrapolative success or failure. |
| AID571693 | Antimicrobial activity against Acinetobacter baumannii alpha clonal group isolate 2 expressing ampC, ompA, adeB, adeM, aacC1, aadA1 by Etest method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Correlation of antimicrobial resistance with beta-lactamases, the OmpA-like porin, and efflux pumps in clinical isolates of Acinetobacter baumannii endemic to New York City. |
| AID546164 | Antimicrobial activity against AmpC overproducing Pseudomonas aeruginosa isolate Pae-beta-04 with PDC-2 variant by Etest | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Extended-spectrum cephalosporinases in Pseudomonas aeruginosa. |
| AID373772 | Antibacterial activity against imipenem-resistant Acinetobacter baumannii abh36 by broth dilution method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | An OXA-66/OXA-51-like carbapenemase and possibly an efflux pump are associated with resistance to imipenem in Acinetobacter baumannii. |
| AID560092 | Bactericidal activity against Klebsiella pneumoniae isolate 5436 at 1/4 times MIC after 24 hrs by time kill analysis | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | In vitro activity of ceftaroline alone and in combination against clinical isolates of resistant gram-negative pathogens, including beta-lactamase-producing Enterobacteriaceae and Pseudomonas aeruginosa. |
| AID519734 | Antibacterial activity against Escherichia coli DH5alpha with deltaampC by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | The Lys234Arg substitution in the enzyme SHV-72 is a determinant for resistance to clavulanic acid inhibition. |
| AID558049 | Antimicrobial activity against blaKPC-positive Klebsiella pneumoniae S12 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Genetic organization of transposase regions surrounding blaKPC carbapenemase genes on plasmids from Klebsiella strains isolated in a New York City hospital. |
| AID567730 | Antimicrobial activity against wild type Pseudomonas aeruginosa PAO1 by broth macrodilution method | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | Differential selection of single-step AmpC or efflux mutants of Pseudomonas aeruginosa by using cefepime, ceftazidime, or ceftobiprole. |
| AID405089 | Antibacterial activity against blaVIM2-harboring integrons containing Pseudomonas aeruginosa 42 isolate from ventilator-associated pneumonia patient | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | blaVIM-2-harboring integrons isolated in India, Russia, and the United States arise from an ancestral class 1 integron predating the formation of the 3' conserved sequence. |
| AID541007 | Antimicrobial activity against Burkholderia cenocepacia 09-54 expressing beta-lactamase PenB2 | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Naturally occurring Class A ss-lactamases from the Burkholderia cepacia complex. |
| AID559898 | Antimicrobial activity against Klebsiella oxytoca KO281 harboring beta-lactamase OXY-1 and CMY-2 by Etest method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | First detection of plasmid-encoded blaOXY beta-lactamase. |
| AID541010 | Antimicrobial activity against Burkholderia cenocepacia 212 expressing beta-lactamase PenB3 | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Naturally occurring Class A ss-lactamases from the Burkholderia cepacia complex. |
| AID535372 | Antimicrobial activity against Pseudomonas aeruginosa isolated from ICU patient assessed as susceptible isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activity of doripenem, a carbapenem for the treatment of challenging infections caused by gram-negative bacteria, against recent clinical isolates from the United States. |
| AID373047 | Antimicrobial activity against imipenem and meropenem-resistant Acinetobacter baumannii isolate FZ4A18 by CLSI agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Molecular epidemiology of clinical isolates of carbapenem-resistant Acinetobacter spp. from Chinese hospitals. |
| AID544967 | Antimicrobial activity against Proteus mirabilis expressing beta-lactamase AmpC by Etest | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Characterization and sequence analysis of extended-spectrum-{beta}-lactamase-encoding genes from Escherichia coli, Klebsiella pneumoniae, and Proteus mirabilis isolates collected during tigecycline phase 3 clinical trials. |
| AID1373306 | Antimicrobial activity against Escherichia coli expressing beta-lactamase NDM-1 by CLSI broth microdilution method | 2018 | Bioorganic & medicinal chemistry letters, 02-15, Volume: 28, Issue:4 | Optimization of novel monobactams with activity against carbapenem-resistant Enterobacteriaceae - Identification of LYS228. |
| AID554397 | Antimicrobial activity against Pseudomonas aeruginosa isolate 2729 obtained from cystic fibrosis patient by disk diffusion method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Efflux unbalance in Pseudomonas aeruginosa isolates from cystic fibrosis patients. |
| AID322323 | Antibacterial activity against Escherichia coli DH5 alpha-URA5905 isolates expressing CTX-M-15 and TEM-1B enzymes by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Spread of extended-spectrum beta-lactamase CTX-M-producing escherichia coli clinical isolates in community and nosocomial environments in Portugal. |
| AID584847 | Ratio of Kcat to Km for Aeromonas allosaccharophila AL-1 beta-lactamase PER6 | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | PER-6, an extended-spectrum beta-lactamase from Aeromonas allosaccharophila. |
| AID520797 | Antimicrobial activity against CTX-M-59 producing Klebsiella pneumoniae with PFGE pulsotype E by Etest | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Multiclonal outbreak of Klebsiella pneumoniae producing extended-spectrum beta-lactamase CTX-M-2 and novel variant CTX-M-59 in a neonatal intensive care unit in Brazil. |
| AID529643 | Antimicrobial activity against Pseudomonas aeruginosa 9551 expressing beta-lactamase VIM-15 obtained from urine of patient by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | VIM-15 and VIM-16, two new VIM-2-like metallo-beta-lactamases in Pseudomonas aeruginosa isolates from Bulgaria and Germany. |
| AID535636 | Antimicrobial activity against Group B streptococcus serotype VI R4 harboring Q557E mutation in PBP 2X and T567I, Y262N mutations in PBP 2B by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | Genetic heterogeneity in pbp genes among clinically isolated group B Streptococci with reduced penicillin susceptibility. |
| AID524749 | Antimicrobial activity against Escherichia coli GB20 harboring V27A, Q38R, A77V, N114D, A140S, P167T, D288N mutations in beta lactamase CTX-M-1 by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Mutational events in cefotaximase extended-spectrum beta-lactamases of the CTX-M-1 cluster involved in ceftazidime resistance. |
| AID535642 | Antimicrobial activity against Group B streptococcus serotype VI N4 harboring E63K mutation in PBP 2A and L41S mutation in PBP 1B by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | Genetic heterogeneity in pbp genes among clinically isolated group B Streptococci with reduced penicillin susceptibility. |
| AID546166 | Antimicrobial activity against AmpC overproducing Pseudomonas aeruginosa isolate Pae-beta-06 with PDC-2 variant by Etest | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Extended-spectrum cephalosporinases in Pseudomonas aeruginosa. |
| AID565717 | Antibacterial activity against oprD, mexB, mexY and mexD expressing Pseudomonas aeruginosa isolate Paebeta-22 harboring A residue at 105 position in PDC- 4 by Etest method in presence of cloxacillin | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Molecular epidemiology and mechanisms of carbapenem resistance in Pseudomonas aeruginosa. |
| AID573359 | Antibacterial activity against ceftazidime-susceptible Klebsiella pneumoniae assessed as susceptible isolates by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID325207 | Stability in presence of AmpC beta-lactamase | 2008 | Bioorganic & medicinal chemistry, Feb-15, Volume: 16, Issue:4 | A novel series of parenteral cephalosporins exhibiting potent activities against both Pseudomonas aeruginosa and other gram-negative pathogens. Part 2: Synthesis and structure-activity relationships. |
| AID520803 | Antimicrobial activity against Escherichia coli str. K-12 substr. DH10B harboring plasmid CTX-M-2 | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Multiclonal outbreak of Klebsiella pneumoniae producing extended-spectrum beta-lactamase CTX-M-2 and novel variant CTX-M-59 in a neonatal intensive care unit in Brazil. |
| AID573204 | Antimicrobial activity against mutS::lox-deficient Pseudomonas aeruginosa PAOMSB biofilm harboring nfxB T41C mutant gene selected at 4 ug/ml of azithromycin after 3 passages by Etest method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Azithromycin in Pseudomonas aeruginosa biofilms: bactericidal activity and selection of nfxB mutants. |
| AID499061 | Antimicrobial activity against carbapenem-resistant Escherichia coli PU43 deficient in TEM-1, CTX-M-14, aac(6')-Ib, ompC/F by CLSI method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Phenotypic and genotypic characterization of Enterobacteriaceae with decreased susceptibility to carbapenems: results from large hospital-based surveillance studies in China. |
| AID498838 | Antimicrobial activity against carbapenem-resistant Klebsiella pneumoniae SZ61 deficient in TEM-1, SHV-1a, CMY-2, ompK35/36 by CLSI method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Phenotypic and genotypic characterization of Enterobacteriaceae with decreased susceptibility to carbapenems: results from large hospital-based surveillance studies in China. |
| AID535633 | Antimicrobial activity against Group B streptococcus serotype Ia R7 harboring T77I, F395V and S353F in PBP 2X; V80A and G613R in PBP 2B; and L45P, N163K, N723S and Y470F in PBP 1A by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | Genetic heterogeneity in pbp genes among clinically isolated group B Streptococci with reduced penicillin susceptibility. |
| AID495664 | Ratio of Kcat to Km for Pseudomonas aeruginosa 51170 beta-lactamase BEL-1 | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | BEL-2, an extended-spectrum beta-lactamase with increased activity toward expanded-spectrum cephalosporins in Pseudomonas aeruginosa. |
| AID522570 | Antimicrobial activity against Escherichia coli isolate 7008710 with AmpC beta-lactamase S287N mutation | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Occurrence of ST23 complex phylogroup A Escherichia coli isolates producing extended-spectrum AmpC beta-lactamase in a French hospital. |
| AID556664 | Antimicrobial activity against multidrug resistant Enterobacter aerogenes isolate 19 by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Occurrence of efflux mechanism and cephalosporinase variant in a population of Enterobacter aerogenes and Klebsiella pneumoniae isolates producing extended-spectrum beta-lactamases. |
| AID520978 | Antibacterial activity against Escherichia coli harboring pCOL plasmid expressing blaKPC gene by Etest method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Genetic structures at the origin of acquisition of the beta-lactamase bla KPC gene. |
| AID285620 | Antimicrobial activity against Pseudomonas aeruginosa 5H6 tracheal isolates from mechanically ventilated chronic respiratory insufficiency patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID534869 | Antimicrobial activity against ESBL producing Proteus mirabilis assessed as resistant isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activity of doripenem, a carbapenem for the treatment of challenging infections caused by gram-negative bacteria, against recent clinical isolates from the United States. |
| AID562328 | Antimicrobial activity against Chryseobacterium indologenes 597 expressing metallo-beta-lactamase IND-6 after 18 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | IND-6, a highly divergent IND-type metallo-beta-lactamase from Chryseobacterium indologenes strain 597 isolated in Burkina Faso. |
| AID528830 | Antimicrobial activity against CTX-M ESBL producing Escherichia coli isolated from ICU patient respiratory tract assessed as resistant isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Antimicrobial-resistant pathogens in intensive care units in Canada: results of the Canadian National Intensive Care Unit (CAN-ICU) study, 2005-2006. |
| AID574439 | Antimicrobial activity against Escherichia coli DH10B by vitek-2 method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Carbapenem-resistant KPC-2-producing Escherichia coli in a Tel Aviv Medical Center, 2005 to 2008. |
| AID586057 | Antimicrobial activity against Acinetobacter baumannii clinical isolate harboring plasmid encoded ISAba1-blaOXA-51-like gene with nuc upstream sequence by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Emergence and Distribution of Plasmids Bearing the blaOXA-51-like gene with an upstream ISAba1 in carbapenem-resistant Acinetobacter baumannii isolates in Taiwan. |
| AID1373282 | Antimicrobial activity against Escherichia coli expressing beta-lactamase CTXM-15 by CLSI broth microdilution method | 2018 | Bioorganic & medicinal chemistry letters, 02-15, Volume: 28, Issue:4 | Optimization of novel monobactams with activity against carbapenem-resistant Enterobacteriaceae - Identification of LYS228. |
| AID534927 | Antimicrobial activity against Ceftazidime non-susceptible Serratia marcescens assessed as susceptible isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activity of doripenem, a carbapenem for the treatment of challenging infections caused by gram-negative bacteria, against recent clinical isolates from the United States. |
| AID563973 | Ratio of Kcat to Km for Klebsiella pneumoniae 05-560 beta-lactamase NDM-1 | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Characterization of a new metallo-beta-lactamase gene, bla(NDM-1), and a novel erythromycin esterase gene carried on a unique genetic structure in Klebsiella pneumoniae sequence type 14 from India. |
| AID394486 | Ratio of Kcat to Km for Escherichia coli beta-lactamase ACC4 by UV spectrophotometry | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10 | Plasmid-encoded ACC-4, an extended-spectrum cephalosporinase variant from Escherichia coli. |
| AID283540 | Antibacterial activity against Pseudomonas aeruginosa FE57Z with inactivated rplY and mexZ genes by microdilution method | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3 | Cumulative effects of several nonenzymatic mechanisms on the resistance of Pseudomonas aeruginosa to aminoglycosides. |
| AID532401 | Antibacterial activity against VIM-1 producing Pseudomonas aeruginosa clone D3 isolate VA-06X-65 by Etest method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | First countrywide survey of acquired metallo-beta-lactamases in gram-negative pathogens in Italy. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 43 (2.59) | 18.7374 |
| 1990's | 251 (15.14) | 18.2507 |
| 2000's | 580 (34.98) | 29.6817 |
| 2010's | 519 (31.30) | 24.3611 |
| 2020's | 265 (15.98) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be very strong demand-to-supply ratio for research on this compound.
| This Compound (104.93) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 186 (10.71%) | 5.53% |
| Reviews | 113 (6.51%) | 6.00% |
| Case Studies | 197 (11.34%) | 4.05% |
| Observational | 18 (1.04%) | 0.25% |
| Other | 1,223 (70.41%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Phase I, Single and Multiple Ascending Dose Study to Investigate the Safety, Tolerability and Pharmacokinetics of AAI101 Administered Intravenously Alone or in Combination With Piperacillin or Cefepime to Healthy Adult Subjects [NCT03685084] | Phase 1 | 56 participants (Actual) | Interventional | 2013-10-10 | Completed | ||
| Randomized, Double-Blind, Multi-Center Study of Cefepime/AAI101 in Hospitalized Adults With Complicated Urinary Tract Infections, Including Acute Pyelonephritis [NCT03680612] | Phase 2 | 45 participants (Actual) | Interventional | 2017-09-05 | Completed | ||
| A Phase I Open-Label, Single-Centre Study to Assess the Concentration of AAI101 and Cefepime in Epithelial Lining Fluid and Plasma in Healthy Volunteers [NCT03680378] | Phase 1 | 19 participants (Actual) | Interventional | 2017-07-01 | Completed | ||
| A Phase 3, Randomized, Double-blind, Multicenter, Comparative Study to Determine the Efficacy and Safety of Cefepime-zidebactam vs. Meropenem in the Treatment of Complicated Urinary Tract Infection or Acute Pyelonephritis in Adults [NCT04979806] | Phase 3 | 528 participants (Anticipated) | Interventional | 2022-08-28 | Recruiting | ||
| Rational Use of Broad-spectrum Antibiotics as Empiric Antibiotic Therapy in Febrile Neutropenia in Recipients of Allogeneic Hematopoietic Cell Transplantation [NCT03078010] | Phase 2 | 460 participants (Anticipated) | Interventional | 2017-02-10 | Recruiting | ||
| Prospective Randomized Study to Compare Clinical Outcomes in Patients With Osteomyelitis Treated With Intravenous Antibiotics Versus Intravenous Antibiotics With an Early Switch to Oral Antibiotics [NCT02099240] | Early Phase 1 | 11 participants (Actual) | Interventional | 2014-03-06 | Terminated(stopped due to Not enough patient enrollment and lack of staffing) | ||
| A Phase 3, Randomized, Double-Blind, Study to Evaluate the Efficacy and Safety of Cefepime-AAI101 Compared to Piperacillin/Tazobactam in the Treatment of Complicated Urinary Tract Infections, Including Acute Pyelonephritis. [NCT03687255] | Phase 3 | 1,043 participants (Actual) | Interventional | 2018-09-24 | Completed | ||
| An Open-Label Trial to Assess the Safety and Pharmacokinetics of VNRX-5133 in the Epithelial Lining Fluid of Healthy Adult Subjects [NCT03870490] | Phase 1 | 20 participants (Actual) | Interventional | 2019-03-14 | Completed | ||
| An Investigator Initiated, Phase II Single-Center, Randomized, Open-Label, Prospective, Comparative Study to Determine the Efficacy, Safety, and Tolerability of Ceftolozane-Tazobactam Plus Vancomycin, Linezolid Versus Standard of Care Plus Vancomycin, Lin [NCT03485950] | Phase 2 | 100 participants (Actual) | Interventional | 2018-05-16 | Completed | ||
| Six- Versus Twelve-Week Therapy for Non-Surgically-Treated Diabetic Foot Osteomyelitis: A Multicenter Open-Label Controlled Randomized Study [NCT02123628] | Phase 4 | 40 participants (Actual) | Interventional | 2007-06-30 | Completed | ||
| A Study the Population Pharmacokinetics of Children Receiving the Anti-infective Drugs for Treatment of Infectious Disease in Central Nervous System [NCT03960905] | 800 participants (Anticipated) | Observational | 2019-01-01 | Recruiting | |||
| Postoperative Antibiotic Management Duration Following Surgery for Intravenous Drug Abuse (IVDA) Endocarditis (OPTIMAL) [NCT05156437] | Phase 4 | 20 participants (Anticipated) | Interventional | 2022-03-16 | Enrolling by invitation | ||
| Comparing Oral Versus Parenteral Antimicrobial Therapy (COPAT) Trial [NCT05977868] | Phase 4 | 135 participants (Anticipated) | Interventional | 2023-08-04 | Enrolling by invitation | ||
| Efficacy of Extended Infusion of β-lactam Antibiotics for the Treatment of Febrile Neutropenia in Haematologic Patients: a Randomised, Multicentre, Open-label, Superiority Clinical Trial (BEATLE) [NCT04233996] | Phase 4 | 150 participants (Anticipated) | Interventional | 2019-06-05 | Recruiting | ||
| Beta-lactam Continuous Versus Intermittent Infusion and Associated Bacterial Resistance and Therapy Outcomes in Critically Ill Patients With Severe Pneumonia [NCT05102162] | Phase 4 | 35 participants (Actual) | Interventional | 2021-12-17 | Terminated(stopped due to Low recruitment.) | ||
| Early Versus Late Stopping of Antibiotics in Children With Cancer and High-risk Febrile Neutropenia [NCT04948463] | Phase 4 | 312 participants (Anticipated) | Interventional | 2021-11-15 | Recruiting | ||
| Single Dose Cefepime Versus Cefuroxime Plus Metronidazole as a Prophylactic Antibiotic: A Randomized Controlled Study [NCT04009772] | Phase 2/Phase 3 | 500 participants (Anticipated) | Interventional | 2019-07-01 | Recruiting | ||
| A Phase 3, Multi-Center, Randomized, Double-Blind Study to Evaluate the Efficacy and Safety of Cefepime/Nacubactam or Aztreonam/Nacubactam Compared to Imipenem/Cilastatin in the Treatment of Complicated Urinary Tract Infections or Acute Uncomplicated Pyel [NCT05887908] | Phase 3 | 600 participants (Anticipated) | Interventional | 2023-05-23 | Recruiting | ||
| Phase I Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of WCK 5107 Alone and in Combination With Cefepime Administered as Single IV Doses in Healthy Human Volunteers [NCT02532140] | Phase 1 | 88 participants (Actual) | Interventional | 2015-08-31 | Completed | ||
| Pharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs [NCT04278404] | 5,000 participants (Anticipated) | Observational | 2020-03-05 | Recruiting | |||
| A Prospective, Randomized, Double-Blind, Multicenter Study to Establish the Safety and Tolerability of Doripenem Compared With Cefepime in Hospitalized Children With Complicated Urinary Tract Infections [NCT01110408] | Phase 3 | 41 participants (Actual) | Interventional | 2010-12-31 | Terminated(stopped due to Trial terminated early per business decision) | ||
| Prolonged Infusion Cefepime and Nosocomial Infections [NCT02568800] | Phase 3 | 134 participants (Anticipated) | Interventional | 2015-10-31 | Recruiting | ||
| [NCT02709382] | Phase 1 | 48 participants (Actual) | Interventional | 2016-03-31 | Completed | ||
| Efficacy of Cefepime Continuous Infusion Versus an Intermittent Dosing Regimen in Adult Critically Ill Patients With Gram Negative Bacilli Bacteremia [NCT00609375] | Phase 4 | 30 participants (Actual) | Interventional | 2006-09-30 | Completed | ||
| A Multicenter, Randomized, Controlled Trial Comparing Cefepime Monotherapy Versus Combination of Cefazolin Plus Ceftazidime for Empirical Treatment of CAPD-associated Peritonitis [NCT02872038] | Phase 4 | 154 participants (Actual) | Interventional | 2015-08-31 | Completed | ||
| Phase 1, Open-label, Parallel Group, Single-dose Study to Evaluate the Pharmacokinetics, Safety and Tolerability of AAI101 With Cefepime in Subjects With Varying Degrees of Renal Function [NCT03680352] | Phase 1 | 30 participants (Actual) | Interventional | 2017-09-01 | Completed | ||
| Pharmacokinetics and Pharmacodynamic (PK/PD) of Extended-infusion Meropenem, Piperacillin-tazobactam and Cefepime in the Early Phase of Septic Shock [NCT02820987] | Phase 3 | 129 participants (Anticipated) | Interventional | 2016-09-01 | Recruiting | ||
| Randomized, Multicenter, Phase III, Controlled Clinical Trial, to Demonstrate the no Inferiority of Reduced Antibiotic Treatment vs a Broad Spectrum Betalactam Antipseudomonal Treatment in Patients With Bacteremia by Enterobacteriaceae [NCT02795949] | Phase 3 | 344 participants (Actual) | Interventional | 2016-10-31 | Completed | ||
| A Phase 3 Study to Evaluate Cefepime-taniborbactam Compared to Meropenem in Adults With Ventilator Associated Bacterial Pneumonia (VABP) or Ventilated Hospital Acquired Bacterial Pneumonia (vHABP) [NCT06168734] | Phase 3 | 316 participants (Anticipated) | Interventional | 2023-12-31 | Not yet recruiting | ||
| Cefepime vs Ceftazidime as Empirical Therapy for Neutropenic Fever in Pediatric Acute Leukemia: Review of Temperature and Absolute Neutrophil [NCT04187755] | Phase 4 | 72 participants (Actual) | Interventional | 2019-03-01 | Completed | ||
| The Impact of Cefepime and Unictam on Preventing Post-Cesarean Surgical Site Infections [NCT06048692] | Phase 3 | 213 participants (Actual) | Interventional | 2023-01-01 | Active, not recruiting | ||
| Pharmacokinetic Evaluation of Cefepime Administrered Intravenously in Intensive Care Patients [NCT02680600] | 20 participants (Actual) | Interventional | 2014-03-31 | Completed | |||
| An Investigator Initiated, Phase IV Single-Center, Randomized, Open-Label, Prospective Study to Determine the Impact of Serial Procalcitonin on Improving Antimicrobial Stewardship and on the Efficacy, Safety, and Tolerability of Imipenem - Relebactam Plus [NCT04983901] | Phase 2 | 100 participants (Actual) | Interventional | 2021-09-14 | Active, not recruiting | ||
| A Randomized, Comparative Open Label Study of Imipenem Versus Cefepime in Spontaneous Bacterial Peritonitis and to Evaluate the Risk Factors for Treatment Failure. [NCT01852630] | 175 participants (Actual) | Interventional | 2012-12-31 | Completed | |||
| Research Study on the Pharmacokinetic Profile of Intraperitoneal Cefepime in Patients With Continuous Ambulatory Peritoneal Dialysis (CAPD) Peritonitis [NCT00497744] | 6 participants (Anticipated) | Observational | 2005-11-30 | Completed | |||
| A Phase 1, Open-label, Single-dose Study to Investigate the Pharmacokinetics of Intravenous WCK 5222 (FEP-ZID) in Patients With Renal Impairment [NCT02942810] | Phase 1 | 48 participants (Actual) | Interventional | 2016-10-25 | Completed | ||
| Pharmacokinetics of Understudied Drugs Administered to Children Per Standard of Care [NCT01431326] | 3,520 participants (Actual) | Observational | 2011-11-30 | Completed | |||
| Antibiotic Plasma Concentrations During Continuous Renal Replacement Therapy With a High Adsorption Membrane (oXiris®) [NCT04033029] | 20 participants (Actual) | Observational | 2021-01-01 | Completed | |||
| Prolonged Infusion Compared to Standard Infusion Cefepime as Empiric Treatment of Febrile Neutropenia: A Pilot Study [NCT01484015] | Phase 1 | 70 participants (Actual) | Interventional | 2011-02-28 | Completed | ||
| Randomized Controlled Trial Comparing Ciprofloxacin With Cefepime in Febrile Neutropenic Patients With Hematologic Diseases [NCT00137787] | Phase 3 | 51 participants (Actual) | Interventional | 2005-04-30 | Completed | ||
| Multicenter, Double-Blind, Randomized Study to Compare the Safety and Efficacy of Levofloxacin With That of Cefepime in the Treatment of Fever and Neutropenia - Phase IIIB [NCT00020865] | Phase 3 | 0 participants | Interventional | 2001-09-30 | Active, not recruiting | ||
| A Phase 3, Randomized, Double-blind, Multicenter Study Comparing the Efficacy and Safety of Intravenous Infusions of Flomoxef Versus Intravenous Infusions of Cefepime in the Treatment of Subjects With Complicated Urinary Tract Infections Including Pyelone [NCT02302092] | Phase 3 | 13 participants (Actual) | Interventional | 2015-12-01 | Terminated(stopped due to Study was prematurely terminated due to administrative and strategic reasons) | ||
| Continuous-infusion Anti-pseudomonal β-lactams for the Treatment of Acute, Infective Pulmonary Exacerbations in Cystic Fibrosis [NCT01667094] | Phase 4 | 50 participants (Actual) | Interventional | 2012-09-30 | Active, not recruiting | ||
| A Prospective, Randomized, Double-Blind, Multicenter Study to Establish the Safety and Tolerability of Doripenem Compared With Cefepime in Hospitalized Children With Bacterial Pneumonia [NCT01110421] | Phase 3 | 7 participants (Actual) | Interventional | 2010-12-31 | Terminated(stopped due to Trial terminated early per business decision) | ||
| Multicenter, Randomized, Double-Blind Study of Ceftobiprole Versus Comparators in the Treatment of Patients With Fever and Neutropenia [NCT00529282] | Phase 3 | 2 participants (Actual) | Interventional | 2007-10-31 | Terminated(stopped due to Study discontinued due to administrative reasons unrelated to safety) | ||
| TAID Study - A Prospective Interventional Trial on Antibiotics Continuous Infusion at Home [NCT04816968] | Phase 1 | 50 participants (Anticipated) | Interventional | 2021-09-30 | Not yet recruiting | ||
| A Single Blind, Randomised, Multi-centre, Active Controlled, Trial To Evaluate Safety, Tolerability, Pharmacokinetics And Efficacy Of Ceftazidime And Avibactam Compared With Cefepime In Children From 3 Months To Less Than 18 Years Of Age With Complicated [NCT02497781] | Phase 2 | 97 participants (Actual) | Interventional | 2015-09-24 | Completed | ||
| Antibiotic Prophylaxis in Critically Ill Patients After Suspected Aspiration [NCT05079620] | Phase 4 | 100 participants (Anticipated) | Interventional | 2021-11-30 | Recruiting | ||
| Study on Tolerance, Pharmacokinetics and Drug Interaction of YK-1169 in Healthy Volunteers [NCT05588531] | Phase 1 | 66 participants (Actual) | Interventional | 2021-12-20 | Completed | ||
| Phase 4 Study of Once-Daily Intramuscular Cefepime Versus Ceftriaxone for In-Home Treatment of Nursing Home-Acquired Pneumonia [NCT00358202] | Phase 4 | 69 participants (Actual) | Interventional | 2002-03-31 | Completed | ||
| A Phase 3, Multi-Center, Randomized, Single-Blind Study to Assess the Efficacy and Safety of Cefepime/Nacubactam and Aztreonam/Nacubactam Versus Best Available Therapy in Adults With Complicated Urinary Tract Infection, Acute Uncomplicated Pyelonephritis, [NCT05905055] | Phase 3 | 150 participants (Anticipated) | Interventional | 2023-09-22 | Recruiting | ||
| A Phase 1 Study to Evaluate the Safety and Intrapulmonary Pharmacokinetics of Cefepime and Taniborbactam in Healthy Subjects [NCT04951505] | Phase 1 | 30 participants (Actual) | Interventional | 2021-06-29 | Completed | ||
| Antibiotic Profile of Pathogenic Bacteria Isolated From Postsurgical Site Infections in Public Hospitals in Northern Jordan [NCT05106803] | 24 participants (Actual) | Observational | 2019-08-01 | Completed | |||
| Single Group Phase 2 Study to Investigate Pharmacokinetics, Safety and Tolerability of Cefepime-Enmetazobactam Administered by IV Over 2 Hr in Male or Female Participants From Birth to Less Than 18 Years of Age Hospitalised With cUTI [NCT05826990] | Phase 2 | 40 participants (Anticipated) | Interventional | 2023-04-15 | Not yet recruiting | ||
| A Phase 3, Randomized, Double-blind, Active Controlled Noninferiority Study Evaluating the Efficacy, Safety, and Tolerability of Cefepime/VNRX-5133 in Adults With Complicated Urinary Tract Infections (cUTI), Including Acute Pyelonephritis [NCT03840148] | Phase 3 | 661 participants (Actual) | Interventional | 2019-08-07 | Completed | ||
| A Single-Center, Randomized, Open-label, Prospective, Comparative Study to Determine the Efficacy, Safety, and Tolerability of Ceftazidime-Avibactam (CAZ-AVI) Plus Vancomycin or Linezolid Versus Standard of Care Plus Vancomycin or Linezolid as Empiric The [NCT02732327] | Phase 2 | 2 participants (Actual) | Interventional | 2016-05-17 | Terminated(stopped due to No longer aligned with the revised clinical development plan and commercial strategy) | ||
| Efficacy of Oral Antibiotic Therapy Compared to Intravenous Antibiotic Therapy for the Treatment of Diabetic Foot Osteomyelitis (CRO-OSTEOMYELITIS) [NCT02168816] | Phase 2 | 30 participants (Actual) | Interventional | 2014-03-19 | Terminated(stopped due to The study was stopped for feasibility (i.e., low recruitment)) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||