c-Jun N-terminal kinase inhibitor

An EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor that inhibits the action of c-Jun N-terminal kinase.

ChEBI ID: 90172

Members (3)

Member	Definition	Class
5-(5-nitrothiazol-2-ylthio)-1,3,4-thiadiazol-2-amine	A member of the class of thiadiazoles that is 1,3,4-thiadiazol-2-amine which is substituted by a (5-nitro-1,3-thiazol-2-yl)sulfanediyl group at position 5. It is a c-Jun N-terminal kinase inhibitor (IC50 = 0.7uM) and exhibits antibacterial properties.	halicin
luteolin	A tetrahydroxyflavone in which the four hydroxy groups are located at positions 3', 4', 5 and 7. It is thought to play an important role in the human body as an antioxidant, a free radical scavenger, an anti-inflammatory agent and an immune system modulator as well as being active against several cancers.	luteolin
pyrazolanthrone	A member of the class of anthrapyrazoles that is anthra[1,9-cd]pyrazole substituted at position 6 by an oxo group. An inhibitor of c-Jun N-terminal kinase.	anthra[1,9-cd]pyrazol-6(2H)-one

Research

Studies (3,789)

Timeframe	Studies, Drugs with This Role(%)	All Drugs %
pre-1990	32 (0.84)	18.7374
1990's	79 (2.08)	18.2507
2000's	1,082 (28.56)	29.6817
2010's	1,896 (50.04)	24.3611
2020's	700 (18.47)	2.80

Study Types

Publication Type	Studies, Drugs with this Role (%)	All Drugs (%)
Trials	17 (0.44%)	5.53%
Reviews	120 (3.08%)	6.00%
Case Studies	3 (0.08%)	4.05%
Observational	2 (0.05%)	0.25%
Other	3,751 (96.35%)	84.16%

Protein Targets (300)

Potency Measurements

Protein	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Drugs
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	Homo sapiens (human)	Potency	11.2202	1	1
15-lipoxygenase, partial	Homo sapiens (human)	Potency	2.0484	1	2
2,3-bisphosphoglycerate-independent phosphoglycerate mutase	Leishmania major strain Friedlin	Potency	21.3313	1	1
67.9K protein	Vaccinia virus	Potency	21.8968	2	4
acid sphingomyelinase	Homo sapiens (human)	Potency	25.1189	1	1
aldehyde dehydrogenase 1 family, member A1	Homo sapiens (human)	Potency	14.9480	1	6
alpha-galactosidase	Homo sapiens (human)	Potency	50.1187	1	1
AR protein	Homo sapiens (human)	Potency	22.9142	2	2
aryl hydrocarbon receptor	Homo sapiens (human)	Potency	29.8493	2	2
arylsulfatase A	Homo sapiens (human)	Potency	0.6012	1	1
ATAD5 protein, partial	Homo sapiens (human)	Potency	8.2505	2	2
ATP-dependent phosphofructokinase	Trypanosoma brucei brucei TREU927	Potency	22.6614	4	4
atrial natriuretic peptide receptor 1 precursor	Homo sapiens (human)	Potency	8.4921	1	1
Bloom syndrome protein isoform 1	Homo sapiens (human)	Potency	18.7775	2	4
BRCA1	Homo sapiens (human)	Potency	35.4813	1	1
bromodomain adjacent to zinc finger domain 2B	Homo sapiens (human)	Potency	79.4328	1	1
caspase-1 isoform alpha precursor	Homo sapiens (human)	Potency	3.9811	1	1
Caspase-7	Homo sapiens (human)	Potency	3.1623	1	1
Cellular tumor antigen p53	Homo sapiens (human)	Potency	14.0962	2	2
cellular tumor antigen p53 isoform a	Homo sapiens (human)	Potency	6.9212	2	3
Chain A, 2-oxoglutarate Oxygenase	Homo sapiens (human)	Potency	10.7509	1	4
Chain A, ATP-DEPENDENT DNA HELICASE Q1	Homo sapiens (human)	Potency	13.1213	3	6
Chain A, Ferritin light chain	Equus caballus (horse)	Potency	17.7828	1	2
Chain A, HADH2 protein	Homo sapiens (human)	Potency	18.9149	2	4
Chain A, JmjC domain-containing histone demethylation protein 3A	Homo sapiens (human)	Potency	44.6684	1	1
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	Homo sapiens (human)	Potency	16.4448	2	9
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	Homo sapiens (human)	Potency	29.8816	1	2
Chain B, HADH2 protein	Homo sapiens (human)	Potency	18.9149	2	4
cytochrome P450 2C19 precursor	Homo sapiens (human)	Potency	15.8489	1	1
cytochrome P450 2C9 precursor	Homo sapiens (human)	Potency	29.4548	1	3
cytochrome P450 2D6 isoform 1	Homo sapiens (human)	Potency	16.0105	1	2
cytochrome P450 3A4 isoform 1	Homo sapiens (human)	Potency	8.2806	2	6
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	Homo sapiens (human)	Potency	3.7578	1	1
DNA polymerase beta	Homo sapiens (human)	Potency	19.3512	1	2
DNA polymerase eta isoform 1	Homo sapiens (human)	Potency	12.7748	1	2
DNA polymerase iota isoform a (long)	Homo sapiens (human)	Potency	29.4663	1	3
DNA polymerase kappa isoform 1	Homo sapiens (human)	Potency	5.5156	1	6
endonuclease IV	Escherichia coli	Potency	3.9811	1	1
estrogen nuclear receptor alpha	Homo sapiens (human)	Potency	14.2073	5	5
estrogen-related nuclear receptor alpha	Homo sapiens (human)	Potency	23.7101	2	2
euchromatic histone-lysine N-methyltransferase 2	Homo sapiens (human)	Potency	7.7172	1	3
EWS/FLI fusion protein	Homo sapiens (human)	Potency	20.8526	4	5
flap endonuclease 1	Homo sapiens (human)	Potency	12.5038	1	4
GABA theta subunit	Rattus norvegicus (Norway rat)	Potency	8.2806	1	3
galactokinase	Homo sapiens (human)	Potency	47.2690	1	1
Gamma-aminobutyric acid receptor subunit alpha-1	Rattus norvegicus (Norway rat)	Potency	8.2806	1	3
Gamma-aminobutyric acid receptor subunit alpha-2	Rattus norvegicus (Norway rat)	Potency	8.2806	1	3
Gamma-aminobutyric acid receptor subunit alpha-3	Rattus norvegicus (Norway rat)	Potency	8.2806	1	3
Gamma-aminobutyric acid receptor subunit alpha-4	Rattus norvegicus (Norway rat)	Potency	8.2806	1	3
Gamma-aminobutyric acid receptor subunit alpha-5	Rattus norvegicus (Norway rat)	Potency	8.2806	1	3
Gamma-aminobutyric acid receptor subunit alpha-6	Rattus norvegicus (Norway rat)	Potency	8.2806	1	3
Gamma-aminobutyric acid receptor subunit beta-1	Rattus norvegicus (Norway rat)	Potency	8.2806	1	3
Gamma-aminobutyric acid receptor subunit beta-2	Rattus norvegicus (Norway rat)	Potency	8.2806	1	3
Gamma-aminobutyric acid receptor subunit beta-3	Rattus norvegicus (Norway rat)	Potency	8.2806	1	3
Gamma-aminobutyric acid receptor subunit delta	Rattus norvegicus (Norway rat)	Potency	8.2806	1	3
Gamma-aminobutyric acid receptor subunit epsilon	Rattus norvegicus (Norway rat)	Potency	8.2806	1	3
Gamma-aminobutyric acid receptor subunit gamma-1	Rattus norvegicus (Norway rat)	Potency	8.2806	1	3
Gamma-aminobutyric acid receptor subunit gamma-2	Rattus norvegicus (Norway rat)	Potency	8.2806	1	3
Gamma-aminobutyric acid receptor subunit gamma-3	Rattus norvegicus (Norway rat)	Potency	8.2806	1	3
Gamma-aminobutyric acid receptor subunit pi	Rattus norvegicus (Norway rat)	Potency	8.2806	1	3
geminin	Homo sapiens (human)	Potency	17.3628	3	4
GLS protein	Homo sapiens (human)	Potency	20.8954	2	2
glucocerebrosidase	Homo sapiens (human)	Potency	20.3866	1	2
GTP-binding nuclear protein Ran isoform 1	Homo sapiens (human)	Potency	42.8000	1	2
Guanine nucleotide-binding protein G	Homo sapiens (human)	Potency	50.1187	1	1
guanine nucleotide-binding protein G(i) subunit alpha-1 isoform 1	Homo sapiens (human)	Potency	25.1189	1	1
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	Homo sapiens (human)	Potency	12.5893	1	1
Histamine H2 receptor	Cavia porcellus (domestic guinea pig)	Potency	24.3686	2	13
histone-lysine N-methyltransferase 2A isoform 2 precursor	Homo sapiens (human)	Potency	31.6228	1	1
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	Homo sapiens (human)	Potency	8.1235	2	4
importin subunit beta-1 isoform 1	Homo sapiens (human)	Potency	43.4228	2	3
Integrin alpha-IIb	Homo sapiens (human)	Potency	8.8006	1	2
Integrin beta-3	Homo sapiens (human)	Potency	8.8006	1	2
Interferon beta	Homo sapiens (human)	Potency	17.5478	1	6
lamin isoform A-delta10	Homo sapiens (human)	Potency	1.5836	1	2
lethal factor (plasmid)	Bacillus anthracis str. A2012	Potency	13.9893	1	3
Luciferase	Photinus pyralis (common eastern firefly)	Potency	26.3148	2	2
lysosomal alpha-glucosidase preproprotein	Homo sapiens (human)	Potency	25.1189	1	1
Microtubule-associated protein tau	Homo sapiens (human)	Potency	12.1329	1	3
mitogen-activated protein kinase 1	Homo sapiens (human)	Potency	10.0000	1	1
muscleblind-like protein 1 isoform 1	Homo sapiens (human)	Potency	13.8914	1	2
NPC intracellular cholesterol transporter 1 precursor	Homo sapiens (human)	Potency	10.3225	1	1
nuclear factor erythroid 2-related factor 2 isoform 2	Homo sapiens (human)	Potency	24.8445	1	2
nuclear receptor ROR-gamma isoform 1	Mus musculus (house mouse)	Potency	22.7464	2	6
P53	Homo sapiens (human)	Potency	28.1838	1	1
Parkin	Homo sapiens (human)	Potency	19.4763	2	2
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	Homo sapiens (human)	Potency	37.4458	2	3
peripheral myelin protein 22 isoform 1	Homo sapiens (human)	Potency	84.9214	1	1
phosphoglycerate kinase	Trypanosoma brucei brucei TREU927	Potency	28.1838	1	1
phosphopantetheinyl transferase	Bacillus subtilis	Potency	63.0957	1	1
plasminogen precursor	Mus musculus (house mouse)	Potency	17.3495	2	3
polyunsaturated fatty acid lipoxygenase ALOX12	Homo sapiens (human)	Potency	9.1804	1	2
Polyunsaturated fatty acid lipoxygenase ALOX15B	Homo sapiens (human)	Potency	12.9244	1	2
PPM1D protein	Homo sapiens (human)	Potency	17.5478	1	4
Rap guanine nucleotide exchange factor 3	Homo sapiens (human)	Potency	44.6684	1	1
regulator of G-protein signaling 4	Homo sapiens (human)	Potency	37.6858	1	1
RGS12	Homo sapiens (human)	Potency	25.1189	1	1
serine/threonine-protein kinase mTOR isoform 1	Homo sapiens (human)	Potency	20.7491	1	1
Single-stranded DNA cytosine deaminase	Homo sapiens (human)	Potency	79.4328	1	1
Smad3	Homo sapiens (human)	Potency	11.2202	1	1
snurportin-1	Homo sapiens (human)	Potency	43.4228	2	3
survival motor neuron protein isoform d	Homo sapiens (human)	Potency	8.9125	1	1
TAR DNA-binding protein 43	Homo sapiens (human)	Potency	6.3096	1	1
TDP1 protein	Homo sapiens (human)	Potency	22.3111	2	14
thioredoxin reductase	Rattus norvegicus (Norway rat)	Potency	38.4494	2	4
Thrombopoietin	Homo sapiens (human)	Potency	5.0119	2	2
thyroid hormone receptor beta isoform 2	Rattus norvegicus (Norway rat)	Potency	11.8832	2	2
thyroid hormone receptor beta isoform a	Homo sapiens (human)	Potency	44.6684	1	1
thyroid stimulating hormone receptor	Homo sapiens (human)	Potency	39.8107	2	3
urokinase plasminogen activator surface receptor precursor	Mus musculus (house mouse)	Potency	17.3495	2	3
urokinase-type plasminogen activator precursor	Mus musculus (house mouse)	Potency	17.3495	2	3
USP1 protein, partial	Homo sapiens (human)	Potency	40.0748	2	2
vitamin D3 receptor isoform VDRA	Homo sapiens (human)	Potency	50.1187	1	1
WRN	Homo sapiens (human)	Potency	6.5201	2	2

Inhibition Measurements

Protein	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Drugs
1-deoxy-D-xylulose 5-phosphate reductoisomerase	Escherichia coli K-12	IC50	3.4000	1	1
3-oxoacyl-acyl-carrier protein reductase	Plasmodium falciparum (malaria parasite P. falciparum)	IC50	4.0000	1	1
3-oxoacyl-acyl-carrier protein reductase	Plasmodium falciparum (malaria parasite P. falciparum)	Ki	1.3000	2	2
72 kDa type IV collagenase	Homo sapiens (human)	IC50	3.6100	1	1
Acetylcholinesterase	Homo sapiens (human)	Ki	65.8000	1	1
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1	Homo sapiens (human)	IC50	8.2000	1	1
Aldo-keto reductase family 1 member B1	Bos taurus (cattle)	IC50	5.1620	2	2
Aldo-keto reductase family 1 member B1	Homo sapiens (human)	IC50	1.9000	2	2
Aldo-keto reductase family 1 member B1	Rattus norvegicus (Norway rat)	IC50	1.5400	1	1
Aldo-keto reductase family 1 member B10	Homo sapiens (human)	IC50	58.5000	2	2
Alpha-amylase 1A	Homo sapiens (human)	IC50	18.4000	2	2
Alpha-synuclein	Homo sapiens (human)	IC50	28.0000	1	1
Amine oxidase [flavin-containing] A	Homo sapiens (human)	IC50	4.9000	1	1
Amine oxidase [flavin-containing] B	Homo sapiens (human)	IC50	59.7000	1	1
Amyloid-beta precursor protein	Homo sapiens (human)	IC50	6.4000	1	1
Angiotensin-converting enzyme	Oryctolagus cuniculus (rabbit)	IC50	290.0000	2	2
ATP-dependent translocase ABCB1	Homo sapiens (human)	IC50	19.6000	1	1
Aurora kinase B	Homo sapiens (human)	IC50	3.8800	1	1
Beta-hydroxyacyl-ACP dehydratase precursor (Fatty acid synthesis protein)	Plasmodium falciparum (malaria parasite P. falciparum)	IC50	5.0000	1	1
Beta-hydroxyacyl-ACP dehydratase precursor (Fatty acid synthesis protein)	Plasmodium falciparum (malaria parasite P. falciparum)	Ki	11.5000	1	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	Homo sapiens (human)	IC50	8.9000	1	1
Carbonic anhydrase 1	Homo sapiens (human)	Ki	4.5480	2	5
Carbonic anhydrase 12	Homo sapiens (human)	Ki	0.0603	1	1
Carbonic anhydrase 2	Homo sapiens (human)	Ki	3.2863	2	5
Carbonic anhydrase 3	Bos taurus (cattle)	Ki	3.1850	1	4
Carbonic anhydrase 4	Homo sapiens (human)	Ki	2.6066	2	5
Carbonic anhydrase 7	Homo sapiens (human)	Ki	0.0047	1	1
Casein kinase II subunit alpha	Homo sapiens (human)	IC50	0.7500	2	2
Casein kinase II subunit alpha 3	Homo sapiens (human)	IC50	0.5000	1	1
Casein kinase II subunit alpha'	Homo sapiens (human)	IC50	0.8333	3	3
Casein kinase II subunit beta	Homo sapiens (human)	IC50	0.8333	3	3
Cationic trypsin	Bos taurus (cattle)	IC50	35.3000	1	1
Chain A, Casein kinase II subunit alpha	Zea mays	IC50	0.3500	1	3
Chain A, Mitogen-activated protein kinase 10	Homo sapiens (human)	IC50	0.1500	1	3
Chemotaxis protein CheA	Escherichia coli K-12	IC50	111.0000	1	1
Collagenase 3	Homo sapiens (human)	IC50	10.0500	1	1
Cruzipain	Trypanosoma cruzi	IC50	91.5000	2	2
Cyclin homolog	Herpesvirus saimiri (strain 11)	IC50	77.7000	1	4
Cyclin-dependent kinase 1	Homo sapiens (human)	IC50	6.2000	1	1
Cyclin-dependent kinase 1	Oryzias latipes (Japanese medaka)	IC50	77.7000	1	4
Cyclin-dependent kinase 2	Homo sapiens (human)	IC50	20.0000	1	1
Cyclin-dependent kinase 5 activator 1	Homo sapiens (human)	IC50	62.9200	2	5
Cyclin-dependent kinase 6	Homo sapiens (human)	IC50	122.1600	2	5
Cyclin-dependent-like kinase 5	Homo sapiens (human)	IC50	62.9200	2	5
Cytochrome P450 1A1	Homo sapiens (human)	IC50	1.2490	1	1
Cytochrome P450 1A1	Homo sapiens (human)	Ki	1.8967	2	3
Cytochrome P450 1A2	Homo sapiens (human)	IC50	3.3700	1	1
Cytochrome P450 1B1	Homo sapiens (human)	IC50	0.2195	2	2
Cytochrome P450 1B1	Homo sapiens (human)	Ki	1.2280	2	2
Cytosol aminopeptidase	Sus scrofa (pig)	IC50	49.6000	1	1
Death-associated protein kinase 1	Homo sapiens (human)	IC50	21.0000	1	1
Dipeptidyl peptidase 3	Homo sapiens (human)	IC50	22.0000	1	1
Dipeptidyl peptidase 4	Homo sapiens (human)	IC50	0.1200	1	1
DNA topoisomerase 1	Rattus norvegicus (Norway rat)	IC50	2.8300	2	2
Dual specificity protein kinase TTK	Homo sapiens (human)	IC50	0.8987	3	3
Enoyl-[acyl-carrier-protein] reductase [NADH] FabI	Escherichia coli K-12	Ki	7.0500	1	1
Enoyl-acyl-carrier protein reductase	Plasmodium falciparum (malaria parasite P. falciparum)	IC50	2.0000	2	2
Enoyl-acyl-carrier protein reductase	Plasmodium falciparum (malaria parasite P. falciparum)	Ki	2.1000	1	1
Fatty acid synthase	Gallus gallus (chicken)	IC50	62.5000	1	1
Fatty acid synthase	Homo sapiens (human)	IC50	62.5000	1	1
Furin	Homo sapiens (human)	IC50	50.0000	1	1
G-protein coupled receptor 35	Homo sapiens (human)	IC50	18.6000	1	1
G2/mitotic-specific cyclin-B	Marthasterias glacialis (spiny starfish)	IC50	77.7000	1	4
G2/mitotic-specific cyclin-B1	Homo sapiens (human)	IC50	6.2000	1	1
G2/mitotic-specific cyclin-B2	Homo sapiens (human)	IC50	6.2000	1	1
G2/mitotic-specific cyclin-B3	Homo sapiens (human)	IC50	6.2000	1	1
Genome polyprotein	Zika virus	IC50	53.0000	1	1
Glycogen synthase kinase-3 alpha	Homo sapiens (human)	IC50	0.8000	1	1
Glycogen synthase kinase-3 beta	Homo sapiens (human)	IC50	0.8000	1	1
Glycogen synthase kinase-3 beta	Rattus norvegicus (Norway rat)	IC50	77.7000	1	4
histidine kinase	Streptococcus pneumoniae TIGR4	IC50	216.0000	1	1
Histone-lysine N-methyltransferase SETD7	Homo sapiens (human)	IC50	6.0800	1	1
Homeobox protein Nkx-2.5	Mus musculus (house mouse)	IC50	22.0000	1	1
Inositol hexakisphosphate kinase 2	Homo sapiens (human)	IC50	1.3000	1	1
Inositol polyphosphate multikinase	Homo sapiens (human)	IC50	5.5000	1	1
Integrase	Human immunodeficiency virus 1	IC50	17.4500	5	5
integrase, partial	Human immunodeficiency virus 1	IC50	7.8945	2	2
Interferon-induced, double-stranded RNA-activated protein kinase	Homo sapiens (human)	IC50	8.0000	1	1
Interstitial collagenase	Homo sapiens (human)	IC50	3.0300	1	1
Kappa-type opioid receptor	Cavia porcellus (domestic guinea pig)	IC50	0.6600	1	1
Lactoylglutathione lyase	Homo sapiens (human)	IC50	7.7000	1	1
large T antigen	Betapolyomavirus macacae	IC50	11.9000	1	1
lens epithelium-derived growth factor p75	Homo sapiens (human)	IC50	7.8945	2	2
M1-family alanyl aminopeptidase	Plasmodium falciparum 3D7	IC50	22.8600	1	1
Macrophage metalloelastase	Homo sapiens (human)	IC50	0.9800	1	1
MAP kinase-interacting serine/threonine-protein kinase 1	Homo sapiens (human)	IC50	0.1790	1	1
MAP kinase-interacting serine/threonine-protein kinase 2	Homo sapiens (human)	IC50	0.5790	1	1
Matrix metalloproteinase-9	Homo sapiens (human)	IC50	5.6200	1	1
Mitogen-activated protein kinase 10	Homo sapiens (human)	IC50	3.9373	15	18
Mitogen-activated protein kinase 14	Homo sapiens (human)	IC50	30.0900	3	5
Mitogen-activated protein kinase 8	Homo sapiens (human)	IC50	4.9899	14	15
Mitogen-activated protein kinase 9	Homo sapiens (human)	IC50	0.9800	9	10
NADPH oxidase 4	Homo sapiens (human)	IC50	0.8500	1	1
Neuraminidase	Influenza A virus (A/Wilson-Smith/1933(H1N1))	IC50	32.6500	4	4
Neuraminidase	Influenza A virus (A/Wilson-Smith/1933(H1N1))	Ki	19.6000	1	1
Neutrophil elastase	Homo sapiens (human)	IC50	12.7000	1	1
Neutrophil elastase	Homo sapiens (human)	Ki	10.1000	1	1
Poly [ADP-ribose] polymerase 1	Homo sapiens (human)	IC50	4.2329	1	2
Poly [ADP-ribose] polymerase tankyrase-1	Homo sapiens (human)	IC50	2.3994	1	2
Poly [ADP-ribose] polymerase tankyrase-2	Homo sapiens (human)	IC50	1.0858	1	2
polyadenylate-binding protein 1	Homo sapiens (human)	IC50	48.4250	2	2
Polyunsaturated fatty acid 5-lipoxygenase	Homo sapiens (human)	IC50	1.6000	1	1
Polyunsaturated fatty acid lipoxygenase ALOX15	Homo sapiens (human)	IC50	5.0000	1	1
Prostaglandin G/H synthase 1	Ovis aries (sheep)	IC50	3.2000	1	1
Prostaglandin G/H synthase 2	Homo sapiens (human)	IC50	3.2000	1	1
Proteasome subunit beta type-5	Homo sapiens (human)	IC50	1.4000	2	2
Receptor-type tyrosine-protein kinase FLT3	Homo sapiens (human)	IC50	0.8300	1	1
Renin	Homo sapiens (human)	IC50	50.0000	1	1
Replicase polyprotein 1ab	Betacoronavirus England 1	IC50	10.0000	1	1
Replicase polyprotein 1ab	Severe acute respiratory syndrome coronavirus 2	IC50	10.0150	2	2
Replicase polyprotein 1ab	Severe acute respiratory syndrome-related coronavirus	IC50	20.0000	2	2
Seed linoleate 13S-lipoxygenase-1	Glycine max (soybean)	IC50	3.2000	3	3
Seed linoleate 13S-lipoxygenase-1	Glycine max (soybean)	Ki	121.7000	1	1
Serine/threonine-protein kinase pim-1	Homo sapiens (human)	IC50	1.6000	1	1
Serine/threonine-protein kinase/endoribonuclease IRE1	Homo sapiens (human)	IC50	0.7200	1	1
Short transient receptor potential channel 5	Homo sapiens (human)	IC50	10.0000	1	1
Sialidase	Clostridium perfringens	IC50	4.3000	1	1
Sialidase-2	Homo sapiens (human)	IC50	130.0000	1	1
Stromelysin-1	Homo sapiens (human)	IC50	16.2000	1	1
Substance-K receptor	Cavia porcellus (domestic guinea pig)	IC50	33.7000	1	1
Substance-P receptor	Cavia porcellus (domestic guinea pig)	IC50	33.7000	1	1
TPA: protein transporter TIM10	Saccharomyces cerevisiae S288C	IC50	73.4000	2	3
TPA: protein transporter TIM23	Saccharomyces cerevisiae S288C	IC50	6.3100	1	1
Transcription factor GATA-4	Mus musculus (house mouse)	IC50	22.0000	1	1
Transthyretin	Homo sapiens (human)	IC50	6.4000	1	1
Tyrosinase	Homo sapiens (human)	IC50	60.0000	1	1
Tyrosine-protein kinase JAK3	Homo sapiens (human)	IC50	0.9570	2	2
Tyrosine-protein kinase SYK	Homo sapiens (human)	IC50	12.0000	1	1
Tyrosine-protein kinase Yes	Homo sapiens (human)	Ki	2.3800	1	1
Urease subunit alpha	Helicobacter pylori 26695	IC50	35.4000	1	1
Urease subunit beta	Helicobacter pylori 26695	IC50	35.4000	1	1
Xanthine dehydrogenase/oxidase	Bos taurus (cattle)	IC50	10.2000	1	1
Xanthine dehydrogenase/oxidase	Homo sapiens (human)	IC50	6.6300	3	3
Xanthine dehydrogenase/oxidase	Bos taurus (cattle)	Ki	1.9000	1	1
Xanthine dehydrogenase/oxidase	Homo sapiens (human)	Ki	2.9000	1	1

Activation Measurements

Protein	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Drugs
3-phosphoinositide-dependent protein kinase 1	Homo sapiens (human)	Kd	1.2500	1	1
Angiotensin-converting enzyme 2	Homo sapiens (human)	EC50	10.6000	1	1
AP2-associated protein kinase 1	Homo sapiens (human)	Kd	0.0350	1	1
Aurora kinase A	Homo sapiens (human)	Kd	0.9800	1	1
Aurora kinase C	Homo sapiens (human)	Kd	5.3000	1	1
BMP-2-inducible protein kinase	Homo sapiens (human)	Kd	0.0250	1	1
Calcium/calmodulin-dependent protein kinase kinase 2	Homo sapiens (human)	Kd	7.5000	1	1
Calcium/calmodulin-dependent protein kinase type 1	Homo sapiens (human)	Kd	4.1000	1	1
Calcium/calmodulin-dependent protein kinase type 1D	Homo sapiens (human)	Kd	1.4000	1	1
Calcium/calmodulin-dependent protein kinase type 1G	Homo sapiens (human)	Kd	4.2000	1	1
Casein kinase I isoform epsilon	Homo sapiens (human)	Kd	3.1000	1	1
Casein kinase I isoform gamma-1	Homo sapiens (human)	Kd	3.7000	1	1
Chain A, Transthyretin	Homo sapiens (human)	Kd	0.1000	1	5
Chain B, Transthyretin	Homo sapiens (human)	Kd	0.1000	1	2
Cyclin-dependent kinase 16	Homo sapiens (human)	Kd	0.1800	1	1
Cyclin-dependent kinase 2	Homo sapiens (human)	Kd	3.2000	1	1
Cyclin-G-associated kinase	Homo sapiens (human)	Kd	0.0380	1	1
Death-associated protein kinase 2	Homo sapiens (human)	Kd	0.6100	1	1
Death-associated protein kinase 3	Homo sapiens (human)	Kd	0.4100	1	1
Dual specificity protein kinase CLK2	Homo sapiens (human)	Kd	0.3000	1	1
Dual specificity protein kinase CLK4	Homo sapiens (human)	Kd	0.2600	1	1
Dual specificity protein kinase TTK	Homo sapiens (human)	Kd	0.0980	1	1
Ephrin type-A receptor 3	Homo sapiens (human)	Kd	4.0000	1	1
G-protein coupled receptor 35	Homo sapiens (human)	EC50	5.2200	2	2
glycogen synthase kinase-3 beta isoform 1	Homo sapiens (human)	EC50	3.8120	1	1
large T antigen	Betapolyomavirus macacae	EC50	47.9300	1	1
MAP kinase-interacting serine/threonine-protein kinase 2	Homo sapiens (human)	Kd	1.0000	1	1
Mitogen-activated protein kinase 10	Homo sapiens (human)	Kd	0.0220	2	2
Mitogen-activated protein kinase 12	Homo sapiens (human)	Kd	2.4000	1	1
Mitogen-activated protein kinase 8	Homo sapiens (human)	Kd	0.1000	2	2
Mitogen-activated protein kinase 9	Homo sapiens (human)	Kd	0.0840	2	2
Peroxisome proliferator-activated receptor gamma	Mus musculus (house mouse)	EC50	2.3000	1	1
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform	Homo sapiens (human)	Kd	0.4800	1	1
POsterior Segregation	Caenorhabditis elegans	EC50	60.3740	1	1
Procathepsin L	Homo sapiens (human)	EC50	10.6000	1	1
Protein polybromo-1	Homo sapiens (human)	Kd	12.9000	1	1
Replicase polyprotein 1a	Severe acute respiratory syndrome-related coronavirus	EC50	10.6000	2	2
Replicase polyprotein 1ab	Betacoronavirus England 1	EC50	10.6000	1	1
Replicase polyprotein 1ab	Human coronavirus 229E	EC50	10.6000	2	2
Replicase polyprotein 1ab	Severe acute respiratory syndrome coronavirus 2	EC50	10.6000	1	1
Replicase polyprotein 1ab	Severe acute respiratory syndrome-related coronavirus	EC50	10.6000	2	2
Ribosomal protein S6 kinase alpha-2	Homo sapiens (human)	Kd	2.2000	1	1
Ribosomal protein S6 kinase alpha-5	Homo sapiens (human)	Kd	1.7000	1	1
Serine/threonine-protein kinase 16	Homo sapiens (human)	Kd	0.5100	1	1
Serine/threonine-protein kinase 17A	Homo sapiens (human)	Kd	2.1000	1	1
Serine/threonine-protein kinase 3	Mus musculus (house mouse)	Kd	0.2200	1	1
Serine/threonine-protein kinase 38-like	Homo sapiens (human)	Kd	2.3000	1	1
Serine/threonine-protein kinase 4	Homo sapiens (human)	Kd	2.2000	1	1
Serine/threonine-protein kinase MARK2	Homo sapiens (human)	Kd	1.8000	1	1
Serine/threonine-protein kinase pim-2	Homo sapiens (human)	Kd	0.4600	1	1
Serine/threonine-protein kinase PLK4	Homo sapiens (human)	Kd	0.7700	1	1
Serine/threonine-protein kinase ULK3	Mus musculus (house mouse)	Kd	0.6800	1	1
Sodium-dependent dopamine transporter	Rattus norvegicus (Norway rat)	EC50	1.4500	1	1
Sodium-dependent noradrenaline transporter	Homo sapiens (human)	EC50	31.0000	1	1
Spike glycoprotein	Betacoronavirus England 1	EC50	10.6000	1	1
Spike glycoprotein	Severe acute respiratory syndrome-related coronavirus	EC50	10.6000	1	1
STE20-like serine/threonine-protein kinase	Homo sapiens (human)	Kd	2.3000	1	1
TRAF2 and NCK-interacting protein kinase	Homo sapiens (human)	Kd	0.4800	1	1
Transmembrane protease serine 2	Homo sapiens (human)	EC50	10.6000	1	1
Transthyretin	Homo sapiens (human)	Kd	0.0700	1	1
Tyrosine-protein kinase SYK	Homo sapiens (human)	EC50	4.5000	1	1
Zinc finger protein mex-5	Caenorhabditis elegans	EC50	31.0000	1	1

Other Measurements

Protein	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Drugs
Androgen receptor	Homo sapiens (human)	EC150	18.0000	1	1
cystic fibrosis transmembrane conductance regulator ATP-binding cassette sub-family C member 7	Homo sapiens (human)	AC50	29.2700	1	1
Glucocorticoid receptor	Homo sapiens (human)	EC150	18.0000	1	1
Seed linoleate 13S-lipoxygenase-1	Glycine max (soybean)	Km	169.0500	2	2
Seed linoleate 13S-lipoxygenase-1	Glycine max (soybean)	Vmax	0.0105	2	2
Xanthine dehydrogenase/oxidase	Bos taurus (cattle)	Km	32.3500	4	4