Tyrosinemias

A group of disorders which have in common elevations of tyrosine in the blood and urine secondary to an enzyme deficiency. Type I tyrosinemia features episodic weakness, self-mutilation, hepatic necrosis, renal tubular injury, and seizures and is caused by a deficiency of the enzyme fumarylacetoacetase. Type II tyrosinemia features INTELLECTUAL DISABILITY, painful corneal ulcers, and keratoses of the palms and plantar surfaces and is caused by a deficiency of the enzyme TYROSINE TRANSAMINASE. Type III tyrosinemia features INTELLECTUAL DISABILITY and is caused by a deficiency of the enzyme 4-HYDROXYPHENYLPYRUVATE DIOXYGENASE. (Menkes, Textbook of Child Neurology, 5th ed, pp42-3)

Synonym
Tyrosinemias

Excerpt	Reference
"The genetic tyrosinemias are characterized by the accumulation of tyrosine in body fluids and tissues."	( Scott, CR, 2006)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	1 (0.35)	23.3326
1990's	4 (1.42)	12.5806
2000's	106 (37.59)	18.1394
2010's	135 (47.87)	28.8240
2020's	36 (12.77)	9.53

Drug	Relationship Strength	Studies	Trials
alpha-hydroxyglutarate	low	1	0
aminolevulinic acid	low	4	0
adenine	low	2	0
betaine	low	1	0
carnitine	low	5	0
creatine	low	1	0
cytosine	low	1	0
lactic acid	low	1	0
glutaric acid	low	1	0
glycine	low	1	0
homogentisic acid	low	9	0
nitrites	low	1	0
orotic acid	low	1	0
4-hydroxyphenylpyruvic acid	low	5	0
propionic acid	low	1	0
succinic acid	low	1	0
toluene	low	1	0
urea	low	1	0
2,4-dichlorophenoxyacetic acid	low	1	0
acetaminophen	low	1	0
chlorothiazide	low	1	0
deferoxamine	low	1	0
diazoxide	low	2	0
nefazodone	low	1	0
succinylacetone	low	57	0
serine	low	1	0
lysine	low	1	0
aminopyrine	low	1	0
bromodeoxyuridine	low	1	0
galactose	low	1	0
tyrosine	medium	104	3
methionine	low	6	0
phenylalanine	medium	30	1
cytidine	low	1	0
tryptophan	low	1	0
arginine	low	1	0
dichloroacetic acid	low	1	0
mecoprop	low	1	0
2-methyl-4-chlorophenoxyacetic acid	low	1	0
pyrrolidonecarboxylic acid	low	1	0
dichlorprop	low	1	0
isoxazoles	low	1	0
hydrazine	low	2	0
4-hydroxyphenyllactic acid	low	2	0
azacitidine	low	1	0
ninhydrin	low	1	0
isovaleric acid	low	1	0
1,3-cyclohexanedione	low	1	0
oleanolic acid	low	1	0
levulinic acid	low	1	0
acetylcysteine	low	2	0
dicarbethoxydihydrocollidine	low	1	0
ethylnitrosourea	low	2	0
fluorescein	low	2	0
samarium	low	1	0
terbium	low	1	0
europium	low	1	0
gold	low	1	0
fluorine	low	1	0
tiletamine hydrochloride	medium	133	4
18-crown-6	low	1	0
s-adenosylmethionine	low	4	0
adenosine	low	1	0
glutathione disulfide	low	1	0
girard's reagent t	low	1	0
triazoles	low	1	0
pinocembrin	low	1	0
tyrosine methyl ester	low	1	0
n-acetyltyrosine, (dl)-isomer	low	1	0
sulcotrione	low	2	0
dansyl hydrazine	low	1	0
s-ethyl glutathione	low	1	0
peroxynitrous acid	low	1	0
imatinib mesylate	low	1	0
3-(4-carboxybenzoyl)-2-quinolinecarboxaldehyde	low	1	0
hawkinsin	low	2	0
mesotrione	medium	3	1
canavanine	low	1	0
hexacyanoferrate iii	low	1	0
maleic acid	low	1	0
tacrolimus	low	1	0
(+)-usnic acid	low	1	0
D-fructopyranose	low	1	0
leptospermone	low	1	0
bilirubin	low	2	0
fumarylacetoacetate	low	6	0
lysophosphatidylcholines	low	1	0
topramezone	low	1	0
tembotrione	low	1	0
pituitrin	low	1	0
alpha(-(cyclopropylcarbonyl)-2-(methyvlsulfonyl)-beta-oxo-4-(trifluromethyl)benzenepropanenitrile)	low	2	0
cytochrome c-t	low	1	0
c-peptide	low	1	0
heme	low	3	0
ascorbic acid	low	1	0
cyclosporine	low	1	0
technetium tc 99m dimercaptosuccinic acid	low	1	0
acyclovir	low	2	0
sapropterin	low	1	0
eye	low	1	0

Protein Targets (646)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Fructose-1,6-bisphosphatase 1	0	1	0	1
Fructose-1,6-bisphosphatase 1	0	1	0	1
Enoyl-[acyl-carrier-protein] reductase [NADH] FabI	0	1	0	1
Tyrosine-protein phosphatase non-receptor type 1	0	3	0	3
4-hydroxyphenylpyruvate dioxygenase	0	6	0	7
Integrase	0	1	0	1
Tyrosyl-DNA phosphodiesterase 1	0	1	0	1
estrogen-related nuclear receptor alpha	25	0	0	25
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	9	0	0	9
Cocaine esterase	0	1	0	1
Coagulation factor XII	0	1	0	1
Cholinesterase	0	1	0	1
Liver carboxylesterase 1	0	1	0	1
Acetylcholinesterase	0	3	0	3
Liver carboxylesterase 1	0	2	0	2
Transthyretin	0	1	0	1
Chain A, Beta-lactamase	9	0	0	9
Luciferase	5	0	0	5
RAR-related orphan receptor gamma	16	0	0	16
GLI family zinc finger 3	15	0	0	15
AR protein	19	0	0	19
retinoic acid nuclear receptor alpha variant 1	23	0	0	23
retinoid X nuclear receptor alpha	16	0	0	16
estrogen nuclear receptor alpha	30	0	0	30
peroxisome proliferator activated receptor gamma	8	0	0	8
vitamin D (1,25- dihydroxyvitamin D3) receptor	9	0	0	9
chromobox protein homolog 1	14	0	0	14
thyroid hormone receptor beta isoform 2	15	0	0	15
nuclear factor erythroid 2-related factor 2 isoform 1	15	0	0	15
geminin	18	0	0	18
Inositol monophosphatase 1	2	0	0	2
TAR DNA-binding protein 43	2	0	0	2
Prostaglandin D2 receptor	0	1	0	1
Prostaglandin D2 receptor 2	0	1	0	1
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	4	0	0	4
thioredoxin reductase	7	0	0	7
SMAD family member 2	5	0	0	5
SMAD family member 3	5	0	0	5
progesterone receptor	10	0	0	10
peroxisome proliferator-activated receptor delta	10	0	0	10
serine/threonine-protein kinase PLK1	2	0	0	2
Pyruvate dehydrogenase E1 component subunit alpha, mitochondrial	0	1	0	1
Pyruvate dehydrogenase E1 component subunit beta, mitochondrial	0	1	0	1
Guanine nucleotide-binding protein G	4	0	0	4
Chain A, Penicillin Amidohydrolase	0	2	0	2
Chain B, Penicillin Amidohydrolase	0	2	0	2
Chain A, Penicillin Amidohydrolase	0	2	0	2
Chain B, Penicillin Amidohydrolase	0	2	0	2
Chain A, Penicillin Amidohydrolase	0	2	0	2
Chain B, Penicillin Amidohydrolase	0	2	0	2
Chain A, Penicillin Amidohydrolase	0	2	0	2
Chain B, Penicillin Amidohydrolase	0	2	0	2
Chain A, Penicillin Amidohydrolase	0	2	0	2
Chain B, Penicillin Amidohydrolase	0	2	0	2
Chain A, Penicillin Amidohydrolase	0	2	0	2
Chain B, Penicillin Amidohydrolase	0	2	0	2
Chain A, Penicillin Amidohydrolase	0	2	0	2
Chain B, Penicillin Amidohydrolase	0	2	0	2
Chain A, PROTOCATECHUATE 3,4-DIOXYGENASE	0	1	0	1
Chain M, PROTOCATECHUATE 3,4-DIOXYGENASE	0	1	0	1
Chain A, PROTOCATECHUATE 3,4-DIOXYGENASE	0	1	0	1
Chain M, PROTOCATECHUATE 3,4-DIOXYGENASE	0	1	0	1
Chain A, PROTOCATECHUATE 3,4-DIOXYGENASE	0	1	0	1
Chain M, PROTOCATECHUATE 3,4-DIOXYGENASE	0	1	0	1
Chain A, PROTOCATECHUATE 3,4-DIOXYGENASE	0	1	0	1
Chain M, PROTOCATECHUATE 3,4-DIOXYGENASE	0	1	0	1
Chain A, PROTOCATECHUATE 3,4-DIOXYGENASE	0	1	0	1
Chain M, PROTOCATECHUATE 3,4-DIOXYGENASE	0	1	0	1
Chain A, Protocatechuate 3,4-dioxygenase	0	1	0	1
Chain M, Protocatechuate 3,4-dioxygenase	0	1	0	1
Olfactory receptor class A-like protein 1	0	0	1	1
Smad3	6	0	0	6
DNA polymerase iota isoform a (long)	6	0	0	6
Carbonic anhydrase 1	0	4	0	8
Carbonic anhydrase 2	0	4	0	8
Carbonic anhydrase 5A, mitochondrial	0	1	0	5
Carbonic anhydrase	0	1	0	1
Beta-carbonic anhydrase 1	0	1	0	1
Carbonic anhydrase	0	1	0	4
Carbonic anhydrase	0	1	0	4
Calcium/calmodulin-dependent protein kinase type II subunit alpha	0	1	0	1
Carbonic anhydrase 5B, mitochondrial	0	1	0	5
Solute carrier family 22 member 20	0	5	0	5
Solute carrier family 22 member 6	0	5	0	5
Macrophage migration inhibitory factor	0	0	0	1
Amine oxidase [flavin-containing] A	0	0	0	1
Kappa-type opioid receptor	0	0	0	1
ATAD5 protein, partial	6	0	0	6
GLS protein	9	0	0	9
Microtubule-associated protein tau	7	0	0	7
aldehyde dehydrogenase 1 family, member A1	8	0	0	8
thyroid stimulating hormone receptor	12	0	0	12
nuclear receptor subfamily 1, group I, member 3	12	0	0	12
EWS/FLI fusion protein	5	0	0	5
aryl hydrocarbon receptor	7	0	0	7
peripheral myelin protein 22	10	0	0	10
cytochrome P450 3A4 isoform 1	4	0	0	4
Gamma-aminobutyric acid receptor subunit pi	4	0	0	4
ATP-binding cassette sub-family C member 3	0	5	0	5
Multidrug resistance-associated protein 4	0	5	0	5
Solute carrier family 22 member 6	0	2	0	3
Carbonic anhydrase 12	0	1	0	4
UDP-glucuronosyltransferase 1A9	0	0	0	1
Bile salt export pump	0	4	0	4
Voltage-dependent calcium channel gamma-2 subunit	8	0	0	8
Bile salt export pump	0	8	0	8
Cytochrome P450 2B1	0	0	0	1
Cytochrome P450 1A1	0	0	0	1
Myoglobin	0	1	0	1
Cytochrome P450 1A1	0	1	1	3
Cytochrome P450 1A2	0	1	0	2
Prostaglandin G/H synthase 1	0	2	0	2
Carbonic anhydrase 3	0	1	0	4
Cytochrome P450 3A4	0	3	0	5
Cytochrome P450 2D6	0	1	0	1
Cytochrome P450 2C9	0	2	0	2
Polyunsaturated fatty acid lipoxygenase ALOX15	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	4	0	0	4
Sulfotransferase 1A1	0	0	0	2
Gamma-aminobutyric acid receptor subunit delta	4	0	0	4
Gamma-aminobutyric acid receptor subunit gamma-2	4	0	0	4
UDP-glucuronosyltransferase 1-6	0	0	0	1
Glutamate receptor 2	8	0	0	10
Gamma-aminobutyric acid receptor subunit alpha-5	4	0	0	4
Gamma-aminobutyric acid receptor subunit alpha-3	4	0	0	4
Arachidonate 5-lipoxygenase-activating protein	0	1	0	1
UDP-glucuronosyltransferase 1A1	0	0	0	1
Carbonic anhydrase 4	0	3	0	6
Prostaglandin G/H synthase 1	0	2	0	2
Carbonic anhydrase 6	0	1	0	4
Gamma-aminobutyric acid receptor subunit gamma-1	4	0	0	4
Gamma-aminobutyric acid receptor subunit alpha-2	4	0	0	4
Gamma-aminobutyric acid receptor subunit alpha-4	4	0	0	4
Gamma-aminobutyric acid receptor subunit gamma-3	4	0	0	4
Gamma-aminobutyric acid receptor subunit alpha-6	4	0	0	4
Prostaglandin G/H synthase 2	0	1	0	2
Carbonic anhydrase 7	0	2	0	5
Nuclear receptor ROR-gamma	4	0	0	4
Cytochrome P450 2J2	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-1	4	0	0	4
Gamma-aminobutyric acid receptor subunit beta-3	4	0	0	4
Gamma-aminobutyric acid receptor subunit beta-2	4	0	0	4
Carbonic anhydrase 9	0	2	0	5
GABA theta subunit	4	0	0	4
Canalicular multispecific organic anion transporter 1	0	5	0	5
Carbonic anhydrase 15	0	2	0	5
Carbonic anhydrase 13	0	1	0	3
Gamma-aminobutyric acid receptor subunit epsilon	4	0	0	4
Carbonic anhydrase 14	0	1	0	4
toxin B	0	0	0	1
Chain A, JmjC domain-containing histone demethylation protein 3A	3	0	0	3
Chain A, 2-oxoglutarate Oxygenase	5	0	0	5
Chain A, ATP-DEPENDENT DNA HELICASE Q1	4	0	0	4
acetylcholinesterase	10	0	0	10
dopamine D1 receptor	1	0	0	1
15-lipoxygenase, partial	3	0	0	3
pregnane X receptor	4	0	0	4
phosphopantetheinyl transferase	8	0	0	8
USP1 protein, partial	6	0	0	6
NFKB1 protein, partial	4	0	0	4
Thrombopoietin	2	0	0	2
regulator of G-protein signaling 4	4	0	0	4
glucocorticoid receptor [Homo sapiens]	19	0	0	19
farnesoid X nuclear receptor	7	0	0	7
arylsulfatase A	7	0	0	7
euchromatic histone-lysine N-methyltransferase 2	11	0	0	11
Bloom syndrome protein isoform 1	6	0	0	6
D(1A) dopamine receptor	2	0	0	2
thyroid hormone receptor beta isoform a	6	0	0	6
heat shock protein beta-1	5	0	0	5
flap endonuclease 1	4	0	0	4
survival motor neuron protein isoform d	5	0	0	5
muscarinic acetylcholine receptor M1	7	0	0	7
Histone deacetylase 3	0	1	0	1
Histone deacetylase 4	0	1	0	1
Histone deacetylase 1	0	1	0	1
Histone deacetylase 7	0	1	0	1
Histone deacetylase 2	0	1	0	1
Polyamine deacetylase HDAC10	0	1	0	1
Histone deacetylase 11	0	1	0	1
Ataxin-2	7	0	0	7
Histone deacetylase 8	0	1	0	1
Histone deacetylase 6	0	1	0	1
Histone deacetylase 9	0	1	0	1
Histone deacetylase 5	0	1	0	1
ATP-dependent phosphofructokinase	6	0	0	6
Chain E, Purine nucleoside phosphorylase	0	1	0	1
Chain A, HADH2 protein	2	0	0	2
Chain B, HADH2 protein	2	0	0	2
Chain A, Ferritin light chain	5	0	0	5
Thymidine kinase	0	1	0	1
TDP1 protein	14	0	0	14
activating transcription factor 6	8	0	0	8
Histone H2A.x	5	0	0	5
hemoglobin subunit beta	2	0	0	2
atrial natriuretic peptide receptor 1 precursor	1	0	0	1
ubiquitin carboxyl-terminal hydrolase 2 isoform a	1	0	0	1
lamin isoform A-delta10	16	0	0	16
Solute carrier family 22 member 1	0	0	0	1
Purine nucleoside phosphorylase	0	2	0	2
Thymidine kinase, cytosolic	0	1	0	2
POU domain, class 2, transcription factor 2	0	0	0	1
Disintegrin and metalloproteinase domain-containing protein 17	1	0	0	1
Purine nucleoside phosphorylase	0	0	1	1
Solute carrier family 22 member 6	0	1	0	3
Thymidine kinase	0	1	0	1
Solute carrier family 22 member 8	0	0	0	1
Thymidine kinase	0	1	0	1
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	11	0	0	11
Chain A, MTA/SAH nucleosidase	0	1	0	1
Chain A, Ribosome-inactivating protein alpha-trichosanthin	0	0	1	1
Chain A, Ricin A chain	0	0	1	1
Chain A, Ribosome-inactivating protein 3	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
cytochrome P450 family 3 subfamily A polypeptide 4	7	0	0	7
pregnane X nuclear receptor	11	0	0	11
nuclear factor erythroid 2-related factor 2 isoform 2	5	0	0	5
importin subunit beta-1 isoform 1	3	0	0	3
snurportin-1	3	0	0	3
tumor susceptibility gene 101 protein	1	0	0	1
GTP-binding nuclear protein Ran isoform 1	2	0	0	2
Cyclin-dependent kinase 1	0	1	0	1
Heat shock protein HSP 90-beta	0	1	0	1
Xanthine dehydrogenase/oxidase	0	1	0	1
Protein mono-ADP-ribosyltransferase PARP15	0	1	0	1
Leucine-rich repeat serine/threonine-protein kinase 2	0	2	0	2
ATPase family AAA domain-containing protein 5	6	0	0	6
Chain A, Membrane lipoprotein tmpC	0	0	1	1
Chain A, Membrane lipoprotein tmpC	0	0	1	1
Chain A, Membrane lipoprotein tmpC	0	0	1	1
Chain A, Structure of PAE2307 in complex with adenosine	0	0	1	1
Chain B, Structure of PAE2307 in complex with adenosine	0	0	1	1
Chain A, ADENOSINE RECEPTOR A2A	0	1	0	1
Chain A, ADENOSINE RECEPTOR A2A	0	1	0	1
Chain A, tRNA (guanine-N(1)-)-methyltransferase	0	0	1	1
Chain A, Uncharacterized protein MJ0883	0	0	1	1
signal transducer and activator of transcription 6, interleukin-4 induced	1	0	0	1
NPYLR7B	0	0	1	1
IDH1	9	0	0	9
glycogen synthase kinase-3 beta isoform 1	0	0	1	1
mitogen-activated protein kinase 1	2	0	0	2
nuclear receptor ROR-gamma isoform 1	3	0	0	3
high affinity choline transporter 1 isoform a	0	1	0	1
Sodium/nucleoside cotransporter 1	0	2	0	2
Calcium dependent protein kinase	0	1	0	1
Mitogen-activated protein kinase kinase kinase 7	0	0	1	1
Sodium/nucleoside cotransporter 2	0	2	0	2
Rap guanine nucleotide exchange factor 3	2	0	0	2
Epidermal growth factor receptor	0	2	0	2
Phosphoglycerate kinase 1	0	1	0	1
Adenosine deaminase	0	0	0	1
Avidin	0	0	1	1
Adenosine deaminase	0	0	0	1
Glyceraldehyde-3-phosphate dehydrogenase	0	2	0	2
Receptor tyrosine-protein kinase erbB-2	0	1	0	1
Insulin receptor	0	0	0	1
Phosphoglycerate kinase 2	0	1	0	1
Heat shock protein HSP 90-alpha	0	1	1	2
Platelet-derived growth factor receptor beta	0	0	0	1
Adenosine receptor A3	0	3	2	6
Heat shock 70 kDa protein 1A	0	1	0	1
Heat shock cognate 71 kDa protein	0	0	1	1
Fibroblast growth factor receptor 1	0	0	0	1
Inosine-5'-monophosphate dehydrogenase 2	0	1	0	1
Endoplasmin	0	1	1	2
Inosine-5'-monophosphate dehydrogenase 1	0	1	0	1
Fibroblast growth factor receptor 2	0	0	0	1
Fibroblast growth factor receptor 4	0	0	0	1
Fibroblast growth factor receptor 3	0	0	0	1
Streptavidin	0	0	1	1
Adenosylhomocysteinase	0	0	0	1
Adenosine receptor A1	0	1	1	4
Adenosine receptor A3	0	1	0	1
Adenosine receptor A2a	0	2	2	5
Adenosine receptor A2b	0	0	1	2
Adenosine receptor A2b	0	1	1	2
Adenylate kinase 2, mitochondrial	0	1	0	1
Adenosine receptor A1	0	3	2	6
Adenosine receptor A2a	0	1	1	4
Adenylate kinase isoenzyme 1	0	1	0	1
Phosphatidylinositol 4-kinase alpha	0	2	0	3
Adenosine receptor A1	0	0	1	1
Adenosine kinase	0	0	0	1
Adenosine deaminase	0	0	0	1
Equilibrative nucleoside transporter 2	0	2	0	2
Phosphatidylinositol 4-kinase type 2-beta	0	2	0	3
Histone-lysine N-methyltransferase, H3 lysine-79 specific	0	1	0	1
Equilibrative nucleoside transporter 1	0	2	0	2
Phosphatidylinositol 4-kinase type 2-alpha	0	2	0	3
Solute carrier family 28 member 3	0	2	0	2
Adenosine kinase	0	1	0	2
Phosphatidylinositol 4-kinase beta	0	2	0	3
5-methylthioadenosine/S-adenosylhomocysteine deaminase	0	0	0	1
Adenosine transporter 1	0	0	0	1
Methylcytosine dioxygenase TET2	0	2	1	3
4-hydroxyphenylpyruvate dioxygenase	0	0	1	1
bromodomain adjacent to zinc finger domain 2B	5	0	0	5
Gamma-aminobutyric acid receptor subunit rho-1	0	1	0	1
Glutamate receptor 1	0	1	0	1
Glutamate receptor 2	0	1	0	1
Glutamate receptor 3	0	1	0	1
Glutamate receptor ionotropic, kainate 3	0	1	0	1
Solute carrier family 15 member 1	0	1	0	1
Glutamate receptor 4	0	1	0	1
Solute carrier family 15 member 1	0	1	0	1
Solute carrier family 15 member 2	0	1	0	1
interleukin 8	4	0	0	4
estrogen receptor 2 (ER beta)	9	0	0	9
G	2	0	0	2
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	4	0	0	4
v-jun sarcoma virus 17 oncogene homolog (avian)	8	0	0	8
histone deacetylase 9 isoform 3	1	0	0	1
Interferon beta	4	0	0	4
HLA class I histocompatibility antigen, B alpha chain	2	0	0	2
Nicotinate phosphoribosyltransferase	0	1	0	1
Inositol hexakisphosphate kinase 1	2	0	0	2
cytochrome P450 2C9, partial	2	0	0	2
ORF73	0	0	2	2
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
alpha-galactosidase	1	0	0	1
cytochrome P450 2C19 precursor	1	0	0	1
lethal factor (plasmid)	7	0	0	7
Nitric oxide synthase, endothelial	0	0	0	2
Nitric oxide synthase, brain	0	0	1	2
Nitric oxide synthase, brain	0	0	0	1
Nitric oxide synthase, inducible	0	1	0	2
Nitric oxide synthase, inducible	0	2	1	5
Cationic amino acid transporter 3	0	2	0	2
Chain A, Hyaluronidase, phage associated	0	1	0	1
thioredoxin glutathione reductase	2	0	0	2
lethal(3)malignant brain tumor-like protein 1 isoform I	2	0	0	2
Polyphenol oxidase 2	0	1	0	2
Pancreatic alpha-amylase	0	2	0	2
Albumin	0	1	0	1
Urease	0	1	0	1
Prolyl 4-hydroxylase subunit alpha-1	0	0	0	1
Tyrosinase	0	1	0	1
Alpha-2B adrenergic receptor	0	0	1	1
Spike glycoprotein	8	0	0	8
Hyaluronate lyase	0	1	0	1
Prolyl hydroxylase EGLN2	0	0	1	2
Egl nine homolog 1	0	2	2	5
Prolyl hydroxylase EGLN3	0	0	1	2
Hypoxia-inducible factor 1-alpha inhibitor	0	1	0	2
Solute carrier family 23 member 1	0	1	0	1
glp-1 receptor, partial	3	0	0	3
Fumarate hydratase	1	0	0	1
PPM1D protein	1	0	0	1
polyprotein	1	0	0	1
67.9K protein	2	0	0	2
Parkin	1	0	0	1
thyroid stimulating hormone receptor	5	0	0	5
peripheral myelin protein 22 isoform 1	2	0	0	2
cellular tumor antigen p53 isoform a	4	0	0	4
huntingtin isoform 2	1	0	0	1
ras-related protein Rab-9A	1	0	0	1
serine/threonine-protein kinase mTOR isoform 1	3	0	0	3
urokinase-type plasminogen activator precursor	3	0	0	3
plasminogen precursor	3	0	0	3
urokinase plasminogen activator surface receptor precursor	3	0	0	3
histone acetyltransferase KAT2A isoform 1	5	0	0	5
Cellular tumor antigen p53	8	0	0	8
Integrin beta-3	3	0	0	3
Integrin alpha-IIb	3	0	0	3
DNA (cytosine-5)-methyltransferase 1	0	1	0	1
D(1A) dopamine receptor	1	0	0	1
Multidrug and toxin extrusion protein 1	0	1	0	1
Histone-lysine N-methyltransferase EHMT2	0	3	0	3
Chain A, Betaine ABC transporter permease and substrate binding protein	0	0	1	1
Chain A, Osmoprotection protein (ProX)	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Proton-coupled amino acid transporter 1	0	4	0	4
Chain A, Putative fructose-1,6-bisphosphate aldolase	2	0	0	2
Chain A, Cruzipain	1	0	0	1
vitamin D3 receptor isoform VDRA	2	0	0	2
DNA polymerase kappa isoform 1	5	0	0	5
caspase-1 isoform alpha precursor	2	0	0	2
Caspase-7	1	0	0	1
Solute carrier organic anion transporter family member 1B3	0	2	0	3
Solute carrier organic anion transporter family member 1B1	0	3	0	4
nuclear receptor subfamily 1, group I, member 2	1	0	0	1
Nuclear hormone receptor family member daf-12	0	0	1	1
oxysterols receptor LXR-beta isoform 1	0	0	1	1
Thymidine phosphorylase	0	0	0	1
Thymidylate kinase	0	1	0	1
Thymidine kinase	0	0	0	1
Thymidylate kinase	0	1	0	1
Solute carrier family 22 member 5	0	0	0	1
Solute carrier family 22 member 5	0	0	0	1
Solute carrier family 22 member 16	0	0	0	1
Solute carrier family 22 member 21	0	0	0	1
Solute carrier family 22 member 5	0	0	0	1
nonstructural protein 1	1	0	0	1
transcriptional regulator ERG isoform 3	2	0	0	2
Sodium- and chloride-dependent creatine transporter 1	0	1	0	1
Glucose transporter	0	1	0	1
Cdk-related protein kinase 6	0	1	0	1
Protein kinase domain-containing protein	0	1	0	1
Hexose transporter 1	0	1	0	1
Solute carrier family 2, facilitated glucose transporter member 1	0	1	0	1
Deoxycytidine kinase	0	0	0	1
Cytidine deaminase	0	0	0	1
Calcium-dependent protein kinase 1	0	1	0	1
Mitogen-activated protein kinase	0	1	0	1
Proline--tRNA ligase	0	1	0	1
Calcium-dependent protein kinase 4	0	1	0	1
Lysine--tRNA ligase	0	1	0	1
Uridine-cytidine kinase 1	0	0	0	1
Deoxycytidine kinase	0	0	0	1
Thymidylate synthase	0	1	0	1
Thymidylate synthase	0	1	0	1
Thymidylate synthase	0	1	0	1
apical membrane antigen 1, AMA1	1	0	0	1
Lysine-specific demethylase 4A	0	1	0	1
Hypoxia-inducible factor 1-alpha	0	0	1	1
Deoxyhypusine hydroxylase	0	1	0	1
cytochrome P450 2D6 isoform 1	1	0	0	1
Coagulation factor VII	0	1	0	1
Tissue factor	0	2	0	2
Glutamate receptor 1	0	0	0	2
Glutamate receptor 3	0	0	0	2
Glutamate receptor 4	0	0	0	2
Nicotinamide phosphoribosyltransferase	0	0	1	1
ATP-binding cassette sub-family C member 8	0	1	1	2
ATP-sensitive inward rectifier potassium channel 11	0	1	1	2
acid sphingomyelinase	1	0	0	1
WRN	1	0	0	1
Oligo-1,6-glucosidase IMA1	0	1	0	1
Rap guanine nucleotide exchange factor 4	2	0	0	2
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial	0	1	0	1
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial	0	1	0	1
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial	0	1	0	1
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial	0	1	0	1
hypoxia-inducible factor 1 alpha subunit	1	0	0	1
thyrotropin-releasing hormone receptor	2	0	0	2
Beta-galactosidase	0	1	0	1
Lipopolysaccharide heptosyltransferase 1	0	1	0	1
PA-I galactophilic lectin	0	0	1	1
Jacalin	0	0	1	1
Chain A, Protein (aspartate Aminotransferase)	0	0	2	2
Chain A, Aspartate Aminotransferase	0	0	2	2
Solute carrier family 22 member 7	0	0	0	1
Glutathione reductase	0	0	0	1
Multidrug resistance-associated protein 1	0	0	0	1
Histone-lysine N-methyltransferase EHMT1	0	2	0	2
Glycine receptor subunit alpha-1	0	0	1	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Glutamate receptor ionotropic, NMDA 1	0	2	1	6
Sodium- and chloride-dependent glycine transporter 1	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	2	1	6
Glutamate receptor ionotropic, NMDA 2B	0	2	1	6
Glutamate receptor ionotropic, NMDA 2C	0	2	1	6
Large neutral amino acids transporter small subunit 1	0	5	0	6
Glutamate receptor ionotropic, NMDA 2D	0	2	1	6
Glutamate receptor ionotropic, NMDA 3B	0	2	1	6
Serine racemase	0	1	0	1
Olfactory receptor 51E2	0	0	2	2
Glutamate receptor ionotropic, NMDA 3A	0	2	1	6
Sodium- and chloride-dependent glycine transporter 2	0	1	0	1
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	2	0	0	2
DNA repair protein RAD52 homolog isoform a	0	0	0	1
Tyrosine-protein kinase ABL1	0	1	1	2
Cytochrome P450 2C8	0	0	0	1
Mast/stem cell growth factor receptor Kit	0	1	1	2
Breakpoint cluster region protein	0	0	1	1
Platelet-derived growth factor receptor alpha	0	1	1	2
Cytochrome P450 3A5	0	1	0	2
cytochrome P450 2D6	1	0	0	1
Delta-aminolevulinic acid dehydratase	0	2	0	2
Solute carrier family 15 member 2	0	1	0	1
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplast	0	1	0	1
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplast	0	1	0	1
potassium voltage-gated channel subfamily H member 2 isoform d	1	0	0	1
Glutathione reductase, mitochondrial	0	2	0	2
Chain A, Aspartate Aminotransferase	0	0	1	1
Chain B, Aspartate Aminotransferase	0	0	1	1
Chain A, Aspartate Aminotransferase	0	0	1	1
Chain B, Aspartate Aminotransferase	0	0	1	1
Chain A, Aspartate aminotransferase	0	0	1	1
Chain B, Aspartate aminotransferase	0	0	1	1
Chain A, Aspartate aminotransferase	0	0	1	1
Chain A, Aspartate aminotransferase	0	0	1	1
Chain A, Aspartate aminotransferase	0	0	1	1
Chain B, Aspartate aminotransferase	0	0	1	1
5-hydroxytryptamine receptor 2A	0	1	1	2
5-hydroxytryptamine receptor 2C	0	0	1	1
5-hydroxytryptamine receptor 2B	0	0	1	1
Chain A, Methionyl-tRNA synthetase	0	0	1	1
Chain A, Methionyl-tRNA synthetase	0	0	1	1
Chain A, Aminopeptidase	0	1	0	1
Chain A, Methionine aminopeptidase	0	1	0	1
S-ribosylhomocysteine lyase	0	1	0	1
Adenylate cyclase type 5	0	0	0	1
S-adenosylmethionine synthase isoform type-1	0	0	0	1
S-adenosylmethionine synthase isoform type-2	0	0	0	1
Fatty acid synthase	0	1	0	1
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	1	0	0	1
ATP-dependent translocase ABCB1	0	1	0	1
5-hydroxytryptamine receptor 1A	0	0	1	1
5-hydroxytryptamine receptor 2A	0	1	0	1
5-hydroxytryptamine receptor 1A	0	1	0	1
Sodium-dependent noradrenaline transporter	0	0	1	1
Sodium-dependent serotonin transporter	0	1	1	2
Sodium-dependent dopamine transporter	0	0	1	1
caspase 7, apoptosis-related cysteine protease	2	0	0	2
caspase-3	2	0	0	2
polyunsaturated fatty acid lipoxygenase ALOX12	2	0	0	2
Polyunsaturated fatty acid lipoxygenase ALOX15B	1	0	0	1
Histamine H2 receptor	1	0	0	1
Beta-secretase 1	0	1	0	1
4-hydroxyphenylpyruvate dioxygenase	0	1	0	1
4-hydroxyphenylpyruvate dioxygenase	0	1	0	1
4-hydroxyphenylpyruvate dioxygenase	0	1	0	1
Carbonic anhydrase	0	1	0	4
Phosphotyrosine protein phosphatase	0	1	0	1
Hemagglutinin [Cleaved into: Hemagglutinin HA1 chain; Hemagglutinin HA2 chain]	0	0	1	1
Aldo-keto reductase family 1 member B10	0	2	0	2
Glycogen phosphorylase, muscle form	0	1	0	1
Pancreatic alpha-amylase	0	1	0	3
Phospholipase A2	0	1	0	1
DNA polymerase beta	0	1	0	1
DNA polymerase beta	0	1	0	1
Receptor-type tyrosine-protein phosphatase C	0	1	0	1
Receptor-type tyrosine-protein phosphatase F	0	1	0	1
DNA topoisomerase 1	0	0	0	1
DNA topoisomerase 2-alpha	0	0	0	1
Aldo-keto reductase family 1 member B1	0	1	0	1
Tyrosine-protein phosphatase non-receptor type 2	0	1	0	1
Receptor-type tyrosine-protein phosphatase alpha	0	1	0	1
Receptor-type tyrosine-protein phosphatase epsilon	0	1	0	1
Low molecular weight phosphotyrosine protein phosphatase	0	1	0	1
Tyrosine-protein phosphatase non-receptor type 6	0	1	0	1
M-phase inducer phosphatase 2	0	1	0	1
Signal transducer and activator of transcription 3	0	1	0	1
Kappa-type opioid receptor	0	1	0	1
Dual specificity protein phosphatase 3	0	1	0	1
Transcription factor p65	0	1	0	1
Tyrosine-protein phosphatase non-receptor type 11	0	1	0	1
Nuclear factor erythroid 2-related factor 2	0	0	1	1
Env polyprotein	0	0	1	1
G-protein coupled bile acid receptor 1	0	0	1	1
NAD-dependent protein deacylase sirtuin-5, mitochondrial	0	1	0	1
Transmembrane prolyl 4-hydroxylase	0	0	1	1
Protease	0	1	0	1
Solute carrier family 2, facilitated glucose transporter member 9	0	1	1	2
Chain A, AMINOPEPTIDASE	0	1	0	1
Chain A, AMINOPEPTIDASE	0	1	0	1
Voltage-dependent calcium channel subunit alpha-2/delta-1	0	1	0	1
Plasma kallikrein	0	0	0	3
Alkaline phosphatase, tissue-nonspecific isozyme	0	2	0	2
Alkaline phosphatase, tissue-nonspecific isozyme	0	1	0	1
Intestinal-type alkaline phosphatase	0	2	0	2
Intestinal-type alkaline phosphatase	0	1	0	1
5'-nucleotidase	0	1	0	1
Carbonic anhydrase	0	0	0	3
E3 ubiquitin-protein ligase XIAP	0	1	0	1
SLC16A10 protein	0	0	0	3
Carbonic anhydrase-like protein, putative	0	0	0	3
Carbonic anhydrase	0	0	0	3
Large neutral amino acids transporter small subunit 1	0	1	0	1
Carbonic anhydrase	0	0	0	3
Carbonic anhydrase 13	0	0	0	1
Monocarboxylate transporter 10	0	0	0	3
Phospholipase A-2-activating protein	0	2	0	2
Serine/threonine-protein kinase pim-1	0	1	0	1
Cytochrome P450 1B1	0	1	0	1
Free fatty acid receptor 3	0	0	1	1
Free fatty acid receptor 2	0	1	1	2
Free fatty acid receptor 2	0	0	1	1
Met repressor	0	0	2	2
Protein arginine N-methyltransferase 5	0	0	1	1
Histone H3K27 methylase	0	0	0	1
Phenylethanolamine N-methyltransferase	0	0	1	2
S-adenosylmethionine decarboxylase proenzyme	0	1	0	2
Protein-L-isoaspartate(D-aspartate) O-methyltransferase	0	1	0	1
Catechol O-methyltransferase	0	0	0	1
Protein arginine N-methyltransferase 1	0	1	0	1
Methylosome protein 50	0	0	1	1
Acetylcholinesterase	0	1	0	1
Pyruvate kinase PKM	0	0	1	1
Neutral amino acid transporter A	0	1	0	1
Cholinesterase	0	1	0	1
Neutral amino acid transporter B(0)	0	1	0	1
Amino acid transporter	0	1	0	1
Lysine-specific demethylase 4E	0	2	0	2
N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase	0	1	0	1
NADP-dependent malic enzyme, mitochondrial	0	0	0	1
Prolyl 4-hydroxylase	0	1	0	1
Solute carrier family 13 member 3	0	1	0	1
Methyl-accepting chemotaxis protein NahY	0	0	1	1
Lysine-specific demethylase 6B	0	1	0	1
Gamma-butyrobetaine dioxygenase	0	1	0	1
Lysine-specific demethylase 5C	0	1	0	1
Histone lysine demethylase PHF8	0	1	0	1
Lysine-specific demethylase 2A	0	1	0	1
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
UDP-glucuronosyltransferase 2B7	0	0	0	1
UDP-glucuronosyltransferase 1A4	0	0	0	1
Serine/threonine-protein kinase mTOR	0	1	0	1
Peptidyl-prolyl cis-trans isomerase FKBP1A	0	2	1	3
Peptidyl-prolyl cis-trans isomerase FKBP1B	0	0	1	1
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	0	1	0	1
Peptidyl-prolyl cis-trans isomerase FKBP5	0	1	0	1
Splicing factor 3B subunit 3	0	1	0	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	1	0	1
Endolysin	0	0	1	1
Chain A, Trp Rna-binding Attenuation Protein	0	0	1	1
Chain K, Trp Rna-binding Attenuation Protein	0	0	1	1
Chain B, tryptophanyl-tRNA synthetase	0	0	1	1
Chain C, Tryptophanyl-tRNA synthetase II	0	0	1	1
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	1	0	0	1
histone-lysine N-methyltransferase 2A isoform 2 precursor	1	0	0	1
M-phase phosphoprotein 8	1	0	0	1
Dihydrofolate reductase	0	2	0	2
Myeloperoxidase	0	1	0	1
Stromelysin-1	0	1	0	1
Indoleamine 2,3-dioxygenase 1	0	1	0	2
Substance-P receptor	0	1	0	1
Tryptophan 2,3-dioxygenase	0	1	0	2
Uracil nucleotide/cysteinyl leukotriene receptor	0	1	0	1
Tryprostatin B synthase	0	0	0	1
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	0	0	1	1
Chain A, CHORISMATE MUTASE	0	1	0	1
Chain A, TYROSYL-tRNA SYNTHETASE	0	0	1	1
Tubulin--tyrosine ligase	0	1	0	1
Taste receptor type 2 member 14	0	0	0	1
Urease subunit alpha	0	1	0	1
Urease subunit beta	0	1	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(1)

Research Excerpts

Overview

Research

Studies (282)

Protein Targets (646)

Tyrosinemias

Synonyms(1)

Research Excerpts

Overview

Research

Studies (282)

Drugs Studied (119)

Protein Targets (646)