Any substance which when absorbed into a living organism may modify one or more of its functions. The term is generally accepted for a substance taken for a therapeutic purpose, but is also commonly used for abused substances.
ChEBI ID: 23888
| Member | Definition | Class |
|---|---|---|
| vincristine | A vinca alkaloid with formula C46H56N4O10 found in the Madagascar periwinkle, Catharanthus roseus. It is used (commonly as the corresponding sulfate salt)as a chemotherapy drug for the treatment of leukaemia, lymphoma, myeloma, breast cancer and head and neck cancer. | vincristine |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 6 (2.50) | 18.7374 |
| 1990's | 23 (9.58) | 18.2507 |
| 2000's | 77 (32.08) | 29.6817 |
| 2010's | 111 (46.25) | 24.3611 |
| 2020's | 23 (9.58) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 8 (3.25%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 238 (96.75%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 67.9K protein | Vaccinia virus | Potency | 3.0060 | 2 | 2 |
| activating transcription factor 6 | Homo sapiens (human) | Potency | 0.0067 | 1 | 1 |
| AR protein | Homo sapiens (human) | Potency | 8.9926 | 6 | 6 |
| Ataxin-2 | Homo sapiens (human) | Potency | 0.7498 | 1 | 1 |
| ATPase family AAA domain-containing protein 5 | Homo sapiens (human) | Potency | 0.7221 | 2 | 2 |
| Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 0.0084 | 2 | 2 |
| cytochrome P450 2D6 | Homo sapiens (human) | Potency | 27.5404 | 1 | 1 |
| cytochrome P450 family 3 subfamily A polypeptide 4 | Homo sapiens (human) | Potency | 11.5226 | 2 | 2 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 0.4899 | 9 | 9 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 0.3758 | 1 | 1 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 17.7828 | 1 | 1 |
| EWS/FLI fusion protein | Homo sapiens (human) | Potency | 0.0020 | 4 | 4 |
| farnesoid X nuclear receptor | Homo sapiens (human) | Potency | 0.0237 | 1 | 1 |
| Fumarate hydratase | Homo sapiens (human) | Potency | 1.1770 | 1 | 1 |
| geminin | Homo sapiens (human) | Potency | 0.2986 | 1 | 1 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 0.0727 | 2 | 2 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 0.2131 | 1 | 1 |
| Glutamate receptor 2 | Rattus norvegicus (Norway rat) | Potency | 0.0237 | 1 | 1 |
| huntingtin isoform 2 | Homo sapiens (human) | Potency | 0.0178 | 1 | 1 |
| Interferon beta | Homo sapiens (human) | Potency | 0.4706 | 2 | 4 |
| lamin isoform A-delta10 | Homo sapiens (human) | Potency | 0.0011 | 1 | 1 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 0.0944 | 1 | 1 |
| nuclear receptor subfamily 1, group I, member 2 | Rattus norvegicus (Norway rat) | Potency | 3.5481 | 1 | 1 |
| nuclear receptor subfamily 1, group I, member 3 | Homo sapiens (human) | Potency | 0.2295 | 3 | 3 |
| peripheral myelin protein 22 | Rattus norvegicus (Norway rat) | Potency | 0.1862 | 2 | 2 |
| polyprotein | Zika virus | Potency | 1.1770 | 1 | 1 |
| PPM1D protein | Homo sapiens (human) | Potency | 0.1856 | 1 | 2 |
| pregnane X nuclear receptor | Homo sapiens (human) | Potency | 5.1229 | 2 | 2 |
| progesterone receptor | Homo sapiens (human) | Potency | 0.1333 | 1 | 1 |
| RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 0.6876 | 2 | 2 |
| retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 0.2203 | 3 | 3 |
| retinoid X nuclear receptor alpha | Homo sapiens (human) | Potency | 0.0927 | 2 | 2 |
| SMAD family member 2 | Homo sapiens (human) | Potency | 5.3538 | 1 | 1 |
| SMAD family member 3 | Homo sapiens (human) | Potency | 5.3538 | 1 | 1 |
| Smad3 | Homo sapiens (human) | Potency | 0.5623 | 1 | 1 |
| TDP1 protein | Homo sapiens (human) | Potency | 0.1563 | 2 | 4 |
| thioredoxin reductase | Rattus norvegicus (Norway rat) | Potency | 79.4328 | 1 | 1 |
| thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 0.1044 | 2 | 2 |
| v-jun sarcoma virus 17 oncogene homolog (avian) | Homo sapiens (human) | Potency | 0.5807 | 2 | 2 |
| Voltage-dependent calcium channel gamma-2 subunit | Mus musculus (house mouse) | Potency | 0.0237 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| ATP-dependent translocase ABCB1 | Homo sapiens (human) | Ki | 213.0000 | 1 | 1 |
| Beta-tubulin | Leishmania donovani | IC50 | 1.0000 | 1 | 1 |
| Canalicular multispecific organic anion transporter 1 | Homo sapiens (human) | Ki | 802.0000 | 1 | 1 |
| Multidrug resistance-associated protein 1 | Homo sapiens (human) | IC50 | 70.0000 | 1 | 1 |
| Similar to alpha-tubulin isoform 1 | Bos taurus (cattle) | IC50 | 1.8000 | 1 | 2 |
| Solute carrier organic anion transporter family member 1B1 | Homo sapiens (human) | IC50 | 44.0000 | 1 | 1 |
| Solute carrier organic anion transporter family member 1B1 | Homo sapiens (human) | Ki | 42.0000 | 1 | 1 |
| Solute carrier organic anion transporter family member 1B3 | Homo sapiens (human) | IC50 | 23.8900 | 2 | 2 |
| Solute carrier organic anion transporter family member 1B3 | Homo sapiens (human) | Ki | 13.7000 | 2 | 2 |
| Tubulin alpha-1A chain | Homo sapiens (human) | IC50 | 0.5000 | 1 | 1 |
| Tubulin alpha-1B chain | Homo sapiens (human) | IC50 | 0.5000 | 1 | 1 |
| Tubulin alpha-1C chain | Homo sapiens (human) | IC50 | 0.5000 | 1 | 1 |
| Tubulin alpha-3C chain | Homo sapiens (human) | IC50 | 0.5000 | 1 | 1 |
| Tubulin alpha-3E chain | Homo sapiens (human) | IC50 | 0.5000 | 1 | 1 |
| Tubulin alpha-4A chain | Homo sapiens (human) | IC50 | 0.5000 | 1 | 1 |
| Tubulin beta chain | Homo sapiens (human) | IC50 | 0.5000 | 1 | 1 |
| Tubulin beta-1 chain | Homo sapiens (human) | IC50 | 0.5000 | 1 | 1 |
| Tubulin beta-2A chain | Homo sapiens (human) | IC50 | 0.5000 | 1 | 1 |
| Tubulin beta-2B chain | Bos taurus (cattle) | IC50 | 1.8000 | 1 | 1 |
| Tubulin beta-2B chain | Homo sapiens (human) | IC50 | 0.5000 | 1 | 1 |
| Tubulin beta-3 chain | Homo sapiens (human) | IC50 | 0.5000 | 1 | 1 |
| Tubulin beta-4A chain | Homo sapiens (human) | IC50 | 0.5000 | 1 | 1 |
| Tubulin beta-4B chain | Homo sapiens (human) | IC50 | 0.5000 | 1 | 1 |
| Tubulin beta-6 chain | Homo sapiens (human) | IC50 | 0.5000 | 1 | 1 |
| Tubulin beta-8 chain | Homo sapiens (human) | IC50 | 0.5000 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| ATP-dependent translocase ABCB1 | Homo sapiens (human) | Ki1 | 0.4700 | 1 | 1 |
| ATP-dependent translocase ABCB1 | Homo sapiens (human) | Ki2 | 148.0000 | 1 | 1 |